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Aliases for POTEF Gene

Aliases for POTEF Gene

  • POTE Ankyrin Domain Family, Member F 2 3
  • ANKRD26-Like Family C, Member 1B 2 3
  • ANKRD26-Like Family C Member 1B 3 4
  • Chimeric POTE-Actin Protein 3 4
  • A26C1B 3 4
  • Prostate, Ovary, Testis Expressed Protein On Chromosome 2 3
  • POTE Ankyrin Domain Family Member F 3
  • POTE-2 Alpha-Actin 3
  • Beta Actin 3
  • POTE2alpha 3
  • POTEACTIN 3
  • ACTB 3

External Ids for POTEF Gene

Previous Symbols for POTEF Gene

  • A26C1B

Summaries for POTEF Gene

GeneCards Summary for POTEF Gene

POTEF (POTE Ankyrin Domain Family, Member F) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Proteoglycans in cancer. An important paralog of this gene is POTEJ.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POTEF Gene

Genomics for POTEF Gene

Genomic Location for POTEF Gene

Start:
130,073,535 bp from pter
End:
130,129,222 bp from pter
Size:
55,688 bases
Orientation:
Minus strand

Genomic View for POTEF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POTEF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POTEF Gene

Regulatory Elements for POTEF Gene

Proteins for POTEF Gene

  • Protein details for POTEF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5A3E0-POTEF_HUMAN
    Recommended name:
    POTE ankyrin domain family member F
    Protein Accession:
    A5A3E0
    Secondary Accessions:
    • A6NC34

    Protein attributes for POTEF Gene

    Size:
    1075 amino acids
    Molecular mass:
    121445 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Results from the insertion of a beta-actin fragment at the C-terminus in the POTEE paralog gene leading to the formation of a new functional chimeric protein. This insertion occured before the divergence of the Old World monkeys and apes

neXtProt entry for POTEF Gene

Proteomics data for POTEF Gene at MOPED

Post-translational modifications for POTEF Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys55, Lys92, Lys114, Lys116, Lys142, Lys784, and Lys913

Other Protein References for POTEF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POTEF Gene

Domains for POTEF Gene

Gene Families for POTEF Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • POTE :POTE ankyrin domain containing

Protein Domains for POTEF Gene

UniProtKB/Swiss-Prot:

POTEF_HUMAN
Family:
  • In the N-terminal section; belongs to the POTE family.:
    • A5A3E0
  • In the C-terminal section; belongs to the actin family.:
    • A5A3E0
Similarity:
  • Contains 5 ANK repeats.:
    • A5A3E0
genes like me logo Genes that share domains with POTEF: view

Function for POTEF Gene

Gene Ontology (GO) - Molecular Function for POTEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with POTEF: view

miRNA for POTEF Gene

miRTarBase miRNAs that target POTEF

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for POTEF Gene

Localization for POTEF Gene

Subcellular locations from UniProtKB/Swiss-Prot for POTEF Gene

Cytoplasm, cell cortex. Note=Colocalizes with actin filaments.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POTEF Gene COMPARTMENTS Subcellular localization image for POTEF gene
Compartment Confidence
cytosol 3
cytoskeleton 2
golgi apparatus 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for POTEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005737 cytoplasm --
GO:0005938 cell cortex IEA --
GO:0070062 extracellular exosome IDA 23533145
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with POTEF: view

Pathways for POTEF Gene

genes like me logo Genes that share pathways with POTEF: view

Gene Ontology (GO) - Biological Process for POTEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
genes like me logo Genes that share ontologies with POTEF: view

Transcripts for POTEF Gene

mRNA/cDNA for POTEF Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POTEF Gene

POTE ankyrin domain family, member F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POTEF Gene

No ASD Table

Relevant External Links for POTEF Gene

GeneLoc Exon Structure for
POTEF
ECgene alternative splicing isoforms for
POTEF

Expression for POTEF Gene

mRNA expression in normal human tissues for POTEF Gene

mRNA differential expression in normal tissues according to GTEx for POTEF Gene

This gene is overexpressed in Testis (36.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POTEF Gene

SOURCE GeneReport for Unigene cluster for POTEF Gene Hs.580547

mRNA Expression by UniProt/SwissProt for POTEF Gene

A5A3E0-POTEF_HUMAN
Tissue specificity: Expressed in breast cancer cell lines (at protein level).
genes like me logo Genes that share expressions with POTEF: view

Orthologs for POTEF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POTEF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 98 (a)
OneToMany
POTEF 36
  • 98.36 (n)
  • 97.3 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 10 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 8 (a)
ManyToMany
-- 37
  • 38 (a)
ManyToMany
-- 37
  • 13 (a)
ManyToMany
-- 37
  • 11 (a)
ManyToMany
-- 37
  • 10 (a)
ManyToMany
-- 37
  • 10 (a)
ManyToMany
-- 37
  • 37 (a)
ManyToMany
-- 37
  • 41 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Poteg 37
  • 23 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 38 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 8 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100361457 36
  • 85.24 (n)
  • 90.93 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 12 (a)
OneToMany
ACTBL2 36
  • 74.6 (n)
  • 86.1 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 37 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ANKRD7 37
  • 8 (a)
OneToMany
zgc:86725 36
  • 78.43 (n)
  • 84.76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001676 36
  • 77.99 (n)
  • 84.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta Act88F 36
  • 82.44 (n)
  • 89.04 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ACT3 36
  • 72.74 (n)
  • 82.04 (a)
rice
(Oryza sativa)
Liliopsida Os03g0836000 36
  • 73.1 (n)
  • 83.11 (a)
Species with no ortholog for POTEF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POTEF Gene

ENSEMBL:
Gene Tree for POTEF (if available)
TreeFam:
Gene Tree for POTEF (if available)

Paralogs for POTEF Gene

Pseudogenes.org Pseudogenes for POTEF Gene

genes like me logo Genes that share paralogs with POTEF: view

Variants for POTEF Gene

Sequence variations from dbSNP and Humsavar for POTEF Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1020554 -- 130,125,995(-) TATTG(C/T)CATCT intron-variant
rs1817099 -- 130,107,033(+) AGATG(A/G)CTAAA intron-variant
rs1817100 -- 130,107,054(+) CCTCA(C/T)ACAGT intron-variant
rs1817101 -- 130,084,202(+) GAGGT(A/G)AATAC intron-variant
rs1839841 -- 130,103,059(+) TGTTT(C/T)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POTEF Gene

Variant ID Type Subtype PubMed ID
nsv821629 CNV Loss 15273396
nsv459274 CNV Loss 19166990
nsv875045 CNV Gain 21882294
essv3693 CNV CNV 17122850
dgv1247e1 CNV Complex 17122850
esv2751826 CNV Gain 17911159
dgv1248e1 CNV Complex 17122850
dgv1249e1 CNV Complex 17122850
dgv1250e1 CNV Complex 17122850
nsv428403 CNV Loss 18775914
nsv834374 CNV Gain 17160897
nsv483020 CNV Complex 15286789
dgv1251e1 CNV Complex 17122850
dgv4305n71 CNV Gain 21882294
dgv4306n71 CNV Gain 21882294
essv1878 CNV CNV 17122850
nsv10160 CNV Gain+Loss 18304495
nsv10163 CNV Loss 18304495
nsv875061 CNV Gain 21882294
nsv834375 CNV Loss 17160897
nsv10164 CNV Loss 18304495
nsv7327 OTHER Inversion 18451855
nsv875074 CNV Gain 21882294
dgv4307n71 CNV Gain 21882294

Relevant External Links for POTEF Gene

HapMap Linkage Disequilibrium report
POTEF

Disorders for POTEF Gene

No disorders were found for POTEF Gene.

No data available for UniProtKB/Swiss-Prot for POTEF Gene

Publications for POTEF Gene

  1. Evolution and expression of chimeric POTE-actin genes in the human genome. (PMID: 17101985) Lee Y. … Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Identification of a novel actin isoform in hepatocellular carcinoma. (PMID: 16824795) Chang K.-W. … Yeh C.-T. (Hepatol. Res. 2006) 3
  4. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PMID: 17370265) Denis N.J. … Figeys D. (Proteomics 2007) 3
  5. A primate-specific POTE-actin fusion protein plays a role in apoptosis. (PMID: 19669888) Liu X.F. … Pastan I. (Apoptosis 2009) 3

Products for POTEF Gene

Sources for POTEF Gene

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