POTEF Gene
protein-coding GIFtS: 38
GCID: GC02M130831
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POTE ankyrin domain family, member F(Previous names: ANKRD26-like family C, member 1B )
(Previous symbol: A26C1B)
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Aliases
for POTEF gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| POTE Ankyrin Domain Family, Member F1 2 | | ANKRD26-Like Family C Member 1B2 3 | | A26C1B1 2 3 | | ACTB2 | | POTE2alpha1 2 | | Beta Actin2 | | POTEACTIN1 2 | | POTE Ankyrin Domain Family Member F2 | | ANKRD26-Like Family C, Member 1B1 2 | | POTE-2 Alpha-Actin2 | | Chimeric POTE-Actin Protein2 3 | | Prostate, Ovary, Testis Expressed Protein On Chromosome 22 |
Export aliases for POTEF gene to outside databasesPrevious GC identifer: GC02M130558 |
Summaries
for POTEF gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
 summary
for POTEF: Actin is a ubiquitous globular protein that is one of the most highly-conserved proteins known. It is found
in two main states; G-actin is the globular monomeric form, whereas F-actin forms helical polymers. Both G-
and F-actin are intrinsically flexible structures - a feature vital in actin's role as a dynamic filament
network. Actin has four major functions. Firstly, F-actin polymers form microfilaments - polar intracellular
'tracks' for kinesin motor proteins, allowing the transport of vesicles, organelles and other cargo. Actin
is a component of the cytoskeleton and links to alpha-actinin, E-cadherin and beta-catenin at adherens
junctions. This gives mechanical support to cells and attaches them to each other and the extracellular
matrix. In muscle cells, actin-rich thin filaments associate with myosin-rich thick filaments to form
actomyosin myofibrils. Using energy from the hydrolysis of ATP, myofibrils undergo cyclic shortening through
actin-myosin head interactions, which represents the mechanics of muscle contraction. Finally, actin has a
role in cell motility through polymerization and depolymerization of fibrils.
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Genomic Views
for POTEF gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the POTEF gene promoter:
AML1a NF-YA HSF1 (long) NF-YB CBF-A CBF-B HSF1short CP1A NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for POTEF
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POTEF |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q21.1 Ensembl cytogenetic band: 2q21.1 HGNC cytogenetic band: 2q21.1POTEF Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M130831: view genomic region
(about GC identifiers)
Start:
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130,831,108 bp from pter |
End:
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130,886,795 bp from pter |
Size:
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55,688 bases |
Orientation:
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minus strand |
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Proteins
for POTEF gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: POTEF_HUMAN, A5A3E0 (See
protein sequence)Recommended Name: POTE ankyrin domain family member F Size: 1075 amino acids; 121445 Da
Subcellular location: Cytoplasm, cell cortex. Note=Colocalizes with actin filaments
Miscellaneous: Results from the insertion of a beta-actin fragment at the C-terminus in the POTEE paralog gene leadingto the formation of a new functional chimeric protein. This insertion occured before the divergence of the Old Worldmonkeys and apes
Secondary accessions: A6NC34Explore the universe of human proteins at neXtProt for POTEF: NX_A5A3E0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A5A3E0
POTEF Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001093241.1
ENSEMBL proteins: ENSP00000386786 ENSP00000350052 ENSP00000354232 ENSP00000355012
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005938 | cell cortex |
IEA | -- |
POTEF for ontologies About GeneDecksing
POTEF Antibody Products:
Assay Products for POTEF: |
Protein
Domains /
Families
for POTEF gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
POTEF for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A5A3E0ProtoNet protein and cluster: A5A3E0 UniProtKB/Swiss-Prot: POTEF_HUMAN, A5A3E0Similarity: In the N-terminal section; belongs to the POTE familySimilarity: In the C-terminal section; belongs to the actin familySimilarity: Contains 5 ANK repeats |
Function
for POTEF gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POTEF
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POTEF
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: POTEF (NM_001099771) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POTEF | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat POTEF |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POTEF |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- |
POTEF for ontologies About GeneDecksing
|
Pathways & Interactions
for POTEF gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POTEF
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for POTEF (A5A3E03 ENSP000003500524) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for POTEF gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for POTEF available from Tocris Bioscience About this table
Search CenterWatch for drugs/clinical trials and news about POTEF
|
Transcripts
for POTEF gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for POTEF gene: NM_001099771.2 Unigene Cluster for POTEF: POTE ankyrin domain family, member F Hs.580547 [show with all ESTs]Unigene Representative Sequence: NM_0010997714 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409914 ENST00000357462(uc010fmh.2) ENST00000360967 ENST00000361163
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POTEF
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POTEF
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: POTEF (NM_001099771) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POTEF | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat POTEF |
Additional cDNA sequence: EF523384.1 HM358933.1 HM358938.1 HM358957.1 HM358969.1 HM358981.1 JN038572.1 3 DOTS entries: DT.92010774 DT.97779283 DT.99980275
GeneLoc Exon Structure
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Expression
for POTEF gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| POTEF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See POTEF Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.580547
UniProtKB/Swiss-Prot: POTEF_HUMAN, A5A3E0Tissue specificity: Expressed in breast cancer cell lines (at protein level)
SABiosciences Custom PCR Arrays for POTEF
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POTEF
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat POTEF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POTEF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POTEF | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POTEF |
Orthologs
for POTEF gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for POTEF gene from 5/9 species (see all 9) About this table
ENSEMBL Gene Tree for POTEF (if available)
TreeFam Gene Tree for POTEF (if available) |
Paralogs
for POTEF gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for POTEF gene
- POTEE POTEI2 ANKRD30A2 ANKRD362 ANKRD72 POTEB2 ANKRD30BL2 ANKRD20A32
- POTEH2 ENSG000001552822 ANKRD30B2 ENSG000002663022 ANKRD36C2 POTEJ2 POTEC2 ANKRD20A22
- POTEG2 ANKRD262 ANKRD622 ANKRD18A2 ENSG000001882192 POTEM2 ANKRD20A12 LOC1009963312
- CCDC144A2 POTED2 ANKRD20A42 ANKRD18B2 LOC1002889662
18/55 SIMAP similar genes for POTEF using alignment to 3 protein entries: POTEF_HUMAN (see all proteins)
(see all similar genes):POTEE ACTB POTEKP POTEI ACTG1 ACTA2
ACTC1 ACTG2 PS1TP5BP1 ACT POTEM ACTBL2
POTEC POTEA POTEG POTEJ POTEH POTED
POTEF for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for POTEF
PGOHUM00000233198
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Genomic Variants
for POTEF gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for POTEF (130831108 - 130886795 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for POTEF
10 CNVs: 89970 0269 0024 3393 78762 89971 32364 32365 2408 8387 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POTEF |
|
Disorders
/ Diseases
for POTEF gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
POTEF for disorders About GeneDecksing
4  diseases for POTEF: About MalaCardsprostatitis hepatocellular carcinoma breast cancer carcinoma
Export disorders for POTEF gene to outside databases
|
Publications
for POTEF gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for POTEF gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with POTEF) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Evolution and expression of chimeric POTE-actin genes in the human genome. (PubMed id 17101985)1, 2, 3 Lee Y.... Pastan I. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (2012)
- Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
- A catalogue of putative HIV-1 protease host cell subst rates. (PubMed id 22944692)1 Impens F....Gevaert K. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
- A primate-specific POTE-actin fusion protein plays a role in apoptosis. (PubMed id 19669888)1 Liu X.F....Pastan I. (2009)
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External Searches for POTEF gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing POTEF gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing POTEF gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing POTEF gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for POTEF | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for POTEF gene:
Search GeneIP for patents involving POTEF
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for POTEF gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for POTEF | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POTEF | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POTEF | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for POTEF | | OriGene 3'-UTR Clone for POTEF | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POTEF | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POTEF | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for POTEF | | OriGene Custom Protein Services for POTEF | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POTEF | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POTEF | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POTEF | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POTEF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POTEF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POTEF |
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 |  |  |  | |
| | | | Tocris compounds for POTEF |
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 | | | POTEF Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POTEF |
|  |  |  | | | | ThermoFisher Antibodies for POTEF |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat POTEF |
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