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Aliases for POTEE Gene

Aliases for POTEE Gene

  • POTE Ankyrin Domain Family Member E 2 3 5
  • Prostate, Ovary, Testis-Expressed Protein On Chromosome 2 3 4
  • POTE Ankyrin Domain Family, Member E 2 3
  • ANKRD26-Like Family C, Member 1A 2 3
  • ANKRD26-Like Family C Member 1A 3 4
  • A26C1A 3 4
  • POTE-2 3 4
  • POTE2 3 4
  • Protein Expressed In Prostate, Ovary, Testis, And Placenta 2 3
  • Cancer/Testis Antigen Family 104, Member 2 3
  • Cancer/Testis Antigen Family 104 2
  • POTE2gamma 3
  • Member 2 2
  • CT104.2 3
  • A26C1 3

External Ids for POTEE Gene

Previous HGNC Symbols for POTEE Gene

  • A26C1A

Previous GeneCards Identifiers for POTEE Gene

  • GC02P131695
  • GC02P131980
  • GC02M123138
  • GC02P131219
  • GC02P131255

Summaries for POTEE Gene

GeneCards Summary for POTEE Gene

POTEE (POTE Ankyrin Domain Family Member E) is a Protein Coding gene. An important paralog of this gene is ACTRT1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POTEE Gene

Genomics for POTEE Gene

Regulatory Elements for POTEE Gene

Enhancers for POTEE Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POTEE on UCSC Golden Path with GeneCards custom track

Genomic Location for POTEE Gene

131,211,134 bp from pter
131,265,448 bp from pter
54,315 bases
Plus strand

Genomic View for POTEE Gene

Genes around POTEE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POTEE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POTEE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POTEE Gene

Proteins for POTEE Gene

  • Protein details for POTEE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    POTE ankyrin domain family member E
    Protein Accession:
    Secondary Accessions:
    • Q6S8J4
    • Q6S8J5
    • Q6S8J8

    Protein attributes for POTEE Gene

    1075 amino acids
    Molecular mass:
    121363 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for POTEE Gene


neXtProt entry for POTEE Gene

Proteomics data for POTEE Gene at MOPED

Post-translational modifications for POTEE Gene

  • Ubiquitination at Lys 114, Lys 116, and Lys 684
  • Modification sites at PhosphoSitePlus

Other Protein References for POTEE Gene

No data available for DME Specific Peptides for POTEE Gene

Domains & Families for POTEE Gene

Protein Domains for POTEE Gene

Suggested Antigen Peptide Sequences for POTEE Gene

Graphical View of Domain Structure for InterPro Entry



  • In the N-terminal section; belongs to the POTE family.
  • Contains 5 ANK repeats.
  • In the N-terminal section; belongs to the POTE family.
  • In the C-terminal section; belongs to the actin family.
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with POTEE: view

Function for POTEE Gene

Phenotypes for POTEE Gene

GenomeRNAi human phenotypes for POTEE:
genes like me logo Genes that share phenotypes with POTEE: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POTEE Gene

Localization for POTEE Gene

Subcellular locations from

Jensen Localization Image for POTEE Gene COMPARTMENTS Subcellular localization image for POTEE gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3
cytoskeleton 2
golgi apparatus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for POTEE Gene

Pathways & Interactions for POTEE Gene

SuperPathways for POTEE Gene

No Data Available

Gene Ontology (GO) - Biological Process for POTEE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0021762 substantia nigra development IEP 22926577
genes like me logo Genes that share ontologies with POTEE: view

No data available for Pathways by source and SIGNOR curated interactions for POTEE Gene

Drugs & Compounds for POTEE Gene

No Compound Related Data Available

Transcripts for POTEE Gene

mRNA/cDNA for POTEE Gene

(6) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POTEE Gene

POTE ankyrin domain family, member E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POTEE Gene

No ASD Table

Relevant External Links for POTEE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POTEE Gene

mRNA expression in normal human tissues for POTEE Gene

mRNA differential expression in normal tissues according to GTEx for POTEE Gene

This gene is overexpressed in Testis (x31.7) and Prostate (x6.2).

Protein differential expression in normal tissues from HIPED for POTEE Gene

This gene is overexpressed in Skin (23.1), Saliva (16.5), Brain (12.1), and Lung (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POTEE Gene

SOURCE GeneReport for Unigene cluster for POTEE Gene Hs.686146

genes like me logo Genes that share expression patterns with POTEE: view

Protein tissue co-expression partners for POTEE Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for POTEE Gene

Orthologs for POTEE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POTEE Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia POTEF 35
  • 98.6 (n)
  • 97.67 (a)
-- 36
  • 98 (a)
(Rattus norvegicus)
Mammalia LOC100361457 35
  • 85.69 (n)
  • 91.47 (a)
(Bos Taurus)
Mammalia -- 36
  • 10 (a)
(Canis familiaris)
Mammalia -- 36
  • 8 (a)
-- 36
  • 38 (a)
-- 36
  • 13 (a)
-- 36
  • 11 (a)
-- 36
  • 10 (a)
-- 36
  • 10 (a)
-- 36
  • 37 (a)
-- 36
  • 41 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 7 (a)
(Mus musculus)
Mammalia Gm20946 36
  • 25 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 8 (a)
(Gallus gallus)
Aves ACTBL2 35
  • 74.6 (n)
  • 86.63 (a)
-- 36
  • 12 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
(Danio rerio)
Actinopterygii zgc:86725 35
  • 78.79 (n)
  • 85.29 (a)
  • 8 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001676 35
  • 78.34 (n)
  • 85.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta Act88F 35
  • 82.71 (n)
  • 89.57 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ACT3 35
  • 73.01 (n)
  • 83.11 (a)
(Oryza sativa)
Liliopsida Os03g0836000 35
  • 73.28 (n)
  • 84.18 (a)
Species with no ortholog for POTEE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POTEE Gene

Gene Tree for POTEE (if available)
Gene Tree for POTEE (if available)

Paralogs for POTEE Gene Pseudogenes for POTEE Gene

genes like me logo Genes that share paralogs with POTEE: view

Variants for POTEE Gene

Sequence variations from dbSNP and Humsavar for POTEE Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1809108 -- 131,248,510(-) ACATG(C/G)ATCGA intron-variant
rs2897666 -- 131,215,482(-) CTAGC(A/G)TAAGT intron-variant
rs6430642 -- 131,223,219(+) TCTTT(G/T)GTGCA intron-variant
rs6430645 -- 131,224,923(+) GAAGG(G/T)GGAAG intron-variant
rs6430647 -- 131,225,023(+) ATGGG(C/T)CTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POTEE Gene

Variant ID Type Subtype PubMed ID
dgv1247e1 CNV Complex 17122850
nsv7327 OTHER Inversion 18451855
esv2670824 CNV Deletion 23128226
dgv659e201 CNV Deletion 23290073
dgv731e199 CNV Deletion 23128226
nsv524021 CNV Loss 19592680
dgv1252e1 CNV Complex 17122850
essv11772 CNV CNV 17122850
dgv1253e1 CNV Complex 17122850
dgv1254e1 CNV Complex 17122850
nsv428404 CNV Loss 18775914
dgv1255e1 CNV Complex 17122850
nsv10180 CNV Loss 18304495
dgv1256e1 CNV Complex 17122850
essv7904 CNV CNV 17122850
esv34412 CNV Gain 17911159
nsv875106 CNV Loss 21882294

Variation tolerance for POTEE Gene

Gene Damage Index Score: 4.64; 65.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for POTEE Gene

Disorders for POTEE Gene

Relevant External Links for POTEE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for POTEE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POTEE Gene

Publications for POTEE Gene

  1. Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. (PMID: 15276201) Bera T.K. … Pastan I. (Gene 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. Identification of ApoA1, HPX and POTEE genes by omic analysis in breast cancer. (PMID: 24969553) Cine N. … Savli H. (Oncol. Rep. 2014) 3

Products for POTEE Gene

Sources for POTEE Gene