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Aliases for POTEE Gene

Aliases for POTEE Gene

  • POTE Ankyrin Domain Family Member E 2 3 5
  • Prostate, Ovary, Testis-Expressed Protein On Chromosome 2 3 4
  • Cancer/Testis Antigen Family 104, Member 2 2 3
  • ANKRD26-Like Family C Member 1A 3 4
  • A26C1A 3 4
  • POTE-2 3 4
  • POTE2 3 4
  • Protein Expressed In Prostate, Ovary, Testis, And Placenta 2 3
  • POTE Ankyrin Domain Family, Member E 2
  • ANKRD26-Like Family C, Member 1A 2
  • POTE2gamma 3
  • CT104.2 3
  • A26C1 3

External Ids for POTEE Gene

Previous HGNC Symbols for POTEE Gene

  • A26C1A

Previous GeneCards Identifiers for POTEE Gene

  • GC02P131695
  • GC02P131980
  • GC02M123138
  • GC02P131219
  • GC02P131255
  • GC02P131290
  • GC02P131323
  • GC02P131353
  • GC02P131389

Summaries for POTEE Gene

GeneCards Summary for POTEE Gene

POTEE (POTE Ankyrin Domain Family Member E) is a Protein Coding gene. An important paralog of this gene is POTEF.

Additional gene information for POTEE Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POTEE Gene

Genomics for POTEE Gene

Regulatory Elements for POTEE Gene


Genomic Location for POTEE Gene

Chromosome:
2
Start:
131,211,134 bp from pter
End:
131,265,448 bp from pter
Size:
54,315 bases
Orientation:
Plus strand

Genomic View for POTEE Gene

Genes around POTEE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POTEE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POTEE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POTEE Gene

Proteins for POTEE Gene

  • Protein details for POTEE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6S8J3-POTEE_HUMAN
    Recommended name:
    POTE ankyrin domain family member E
    Protein Accession:
    Q6S8J3
    Secondary Accessions:
    • Q6S8J4
    • Q6S8J5
    • Q6S8J8

    Protein attributes for POTEE Gene

    Size:
    1075 amino acids
    Molecular mass:
    121363 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for POTEE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POTEE Gene

Post-translational modifications for POTEE Gene

  • Ubiquitination at Lys114, posLast=116116, and posLast=684684
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for POTEE Gene

Domains & Families for POTEE Gene

Gene Families for POTEE Gene

Suggested Antigen Peptide Sequences for POTEE Gene

Graphical View of Domain Structure for InterPro Entry

Q6S8J3

UniProtKB/Swiss-Prot:

POTEE_HUMAN :
  • In the N-terminal section; belongs to the POTE family.
Family:
  • In the N-terminal section; belongs to the POTE family.
  • In the C-terminal section; belongs to the actin family.
genes like me logo Genes that share domains with POTEE: view

Function for POTEE Gene

Gene Ontology (GO) - Molecular Function for POTEE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with POTEE: view

Phenotypes for POTEE Gene

genes like me logo Genes that share phenotypes with POTEE: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for POTEE
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POTEE Gene

Localization for POTEE Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POTEE gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 3
golgi apparatus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for POTEE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0070062 extracellular exosome IDA 23533145
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with POTEE: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for POTEE Gene

Pathways & Interactions for POTEE Gene

SuperPathways for POTEE Gene

No Data Available

Gene Ontology (GO) - Biological Process for POTEE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0021762 substantia nigra development IEP 22926577
genes like me logo Genes that share ontologies with POTEE: view

No data available for Pathways by source and SIGNOR curated interactions for POTEE Gene

Drugs & Compounds for POTEE Gene

No Compound Related Data Available

Transcripts for POTEE Gene

mRNA/cDNA for POTEE Gene

(8) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POTEE Gene

POTE ankyrin domain family, member E:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for POTEE
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for POTEE Gene

No ASD Table

Relevant External Links for POTEE Gene

GeneLoc Exon Structure for
POTEE
ECgene alternative splicing isoforms for
POTEE

Expression for POTEE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POTEE Gene

mRNA differential expression in normal tissues according to GTEx for POTEE Gene

This gene is overexpressed in Testis (x31.7) and Prostate (x6.2).

Protein differential expression in normal tissues from HIPED for POTEE Gene

This gene is overexpressed in Skin (23.1), Saliva (16.5), Brain (12.1), and Lung (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POTEE Gene



Protein tissue co-expression partners for POTEE Gene

NURSA nuclear receptor signaling pathways regulating expression of POTEE Gene:

POTEE

SOURCE GeneReport for Unigene cluster for POTEE Gene:

Hs.686146
genes like me logo Genes that share expression patterns with POTEE: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for POTEE Gene

Orthologs for POTEE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POTEE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POTEF 33
  • 98.6 (n)
-- 34
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100361457 33
  • 85.69 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 41 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
-- 34
  • 37 (a)
ManyToMany
-- 34
  • 13 (a)
ManyToMany
-- 34
  • 11 (a)
ManyToMany
-- 34
  • 10 (a)
ManyToMany
-- 34
  • 10 (a)
ManyToMany
-- 34
  • 8 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm20946 34
  • 25 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 10 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 8 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 7 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ACTBL2 33
  • 74.6 (n)
-- 34
  • 12 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 37 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:86725 33
  • 78.79 (n)
ANKRD7 34
  • 8 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Act88F 33
  • 82.71 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001676 33
  • 78.34 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ACT3 33
  • 73.01 (n)
rice
(Oryza sativa)
Liliopsida Os03g0836000 33
  • 73.28 (n)
Species where no ortholog for POTEE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POTEE Gene

ENSEMBL:
Gene Tree for POTEE (if available)
TreeFam:
Gene Tree for POTEE (if available)

Paralogs for POTEE Gene

Pseudogenes.org Pseudogenes for POTEE Gene

genes like me logo Genes that share paralogs with POTEE: view

Variants for POTEE Gene

Sequence variations from dbSNP and Humsavar for POTEE Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000083927 -- 131,232,730(+) ATCCT(A/G)GGATC intron-variant
rs1000116647 -- 131,232,100(+) AACCA(G/T)TTTTC intron-variant
rs1000300416 -- 131,259,577(+) TGATA(G/T)CTCAC intron-variant
rs1000384220 -- 131,224,805(+) AAGAG(A/G)AAACC intron-variant
rs1000558067 -- 131,248,168(+) GGCCT(G/T)CGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POTEE Gene

Variant ID Type Subtype PubMed ID
dgv2032n106 OTHER inversion 24896259
dgv4074n100 CNV gain 25217958
dgv4075n100 CNV gain 25217958
dgv4077n100 CNV gain 25217958
dgv4078n100 CNV gain 25217958
dgv4079n100 CNV loss 25217958
dgv616e201 CNV deletion 23290073
dgv731e199 CNV deletion 23128226
esv2670824 CNV deletion 23128226
esv2759092 CNV gain+loss 17122850
esv2760576 CNV gain+loss 21179565
esv34412 CNV gain 17911159
esv3575300 CNV gain 25503493
esv3584078 CNV loss 25503493
esv3592465 CNV loss 21293372
esv3592466 CNV gain 21293372
esv3893348 CNV gain 25118596
nsv1010808 CNV gain 25217958
nsv1014723 CNV loss 25217958
nsv10180 CNV loss 18304495
nsv1147463 OTHER inversion 26484159
nsv428404 CNV loss 18775914
nsv524021 CNV loss 19592680
nsv583139 CNV loss 21841781
nsv7327 OTHER inversion 18451855
nsv961885 CNV duplication 23825009
nsv962007 CNV duplication 23825009
nsv963849 CNV duplication 23825009
nsv963850 CNV duplication 23825009
nsv979265 CNV duplication 23825009
nsv979266 CNV duplication 23825009
nsv998424 CNV loss 25217958

Variation tolerance for POTEE Gene

Gene Damage Index Score: 4.64; 65.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POTEE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POTEE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POTEE Gene

Disorders for POTEE Gene

Relevant External Links for POTEE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POTEE

No disorders were found for POTEE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POTEE Gene

Publications for POTEE Gene

  1. Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. (PMID: 15276201) Bera TK … Pastan I (Gene 2004) 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair. (PMID: 27462432) Herr P … Helleday T (Cell discovery 2015) 3 60
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q … Chinnaiyan AM (Nature communications 2014) 3 60

Products for POTEE Gene

Sources for POTEE Gene

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