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Aliases for POTED Gene

Aliases for POTED Gene

  • POTE Ankyrin Domain Family Member D 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 21 3 4
  • Prostate, Ovary, Testis-Expressed Protein 3 4
  • POTE Ankyrin Domain Family, Member D 2 3
  • ANKRD26-Like Family B, Member 3 2 3
  • ANKRD26-Like Family B Member 3 3 4
  • Ankyrin Repeat Domain 21 2 3
  • ANKRD21 3 4
  • A26B3 3 4
  • POTE 3 4
  • Expressed In Prostate, Ovary, Testis, And Placenta 3
  • Cancer/Testis Antigen Family 104, Member 1 3
  • Cancer/Testis Antigen Family 104 2
  • Protein POTE 4
  • Member 1 2
  • CT104.1 3
  • POTE-21 3
  • POTE21 3

External Ids for POTED Gene

Previous HGNC Symbols for POTED Gene

  • ANKRD21
  • A26B3

Previous GeneCards Identifiers for POTED Gene

  • GC21P013910
  • GC21P014982

Summaries for POTED Gene

GeneCards Summary for POTED Gene

POTED (POTE Ankyrin Domain Family Member D) is a Protein Coding gene. An important paralog of this gene is ANKRD18A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POTED Gene

Genomics for POTED Gene

Regulatory Elements for POTED Gene

Enhancers for POTED Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POTED on UCSC Golden Path with GeneCards custom track

Genomic Location for POTED Gene

13,609,858 bp from pter
13,641,585 bp from pter
31,728 bases
Plus strand

Genomic View for POTED Gene

Genes around POTED on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POTED Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POTED Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POTED Gene

Proteins for POTED Gene

  • Protein details for POTED Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    POTE ankyrin domain family member D
    Protein Accession:
    Secondary Accessions:
    • C9JCF7

    Protein attributes for POTED Gene

    584 amino acids
    Molecular mass:
    66394 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POTED Gene

Proteomics data for POTED Gene at MOPED

Post-translational modifications for POTED Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POTED Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POTED Gene

Domains & Families for POTED Gene

Protein Domains for POTED Gene

Suggested Antigen Peptide Sequences for POTED Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the POTE family.
  • Contains 6 ANK repeats.
  • Belongs to the POTE family.
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with POTED: view

Function for POTED Gene

genes like me logo Genes that share phenotypes with POTED: view

Animal Model Products

miRNA for POTED Gene

miRTarBase miRNAs that target POTED

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POTED Gene

Localization for POTED Gene

Subcellular locations from UniProtKB/Swiss-Prot for POTED Gene

Cell membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for POTED Gene COMPARTMENTS Subcellular localization image for POTED gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for POTED Gene

Pathways & Interactions for POTED Gene

SuperPathways for POTED Gene

No Data Available

Gene Ontology (GO) - Biological Process for POTED Gene


No data available for Pathways by source and SIGNOR curated interactions for POTED Gene

Drugs & Compounds for POTED Gene

No Compound Related Data Available

Transcripts for POTED Gene

mRNA/cDNA for POTED Gene

(3) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for POTED Gene

No ASD Table

Relevant External Links for POTED Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POTED Gene

mRNA expression in normal human tissues for POTED Gene

mRNA differential expression in normal tissues according to GTEx for POTED Gene

This gene is overexpressed in Testis (x52.9).

Protein differential expression in normal tissues from HIPED for POTED Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POTED Gene

mRNA Expression by UniProt/SwissProt for POTED Gene

Tissue specificity: Expressed in prostate, ovary, testis, placenta and prostate cancer cell lines. Localizes to basal and terminal prostate epithelial cells.
genes like me logo Genes that share expression patterns with POTED: view

Protein tissue co-expression partners for POTED Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for POTED Gene

Orthologs for POTED Gene

This gene was present in the common ancestor of chordates.

Orthologs for POTED Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 6 (a)
(Canis familiaris)
Mammalia -- 36
  • 7 (a)
-- 36
  • 38 (a)
-- 36
  • 12 (a)
-- 36
  • 9 (a)
-- 36
  • 6 (a)
-- 36
  • 6 (a)
-- 36
  • 37 (a)
-- 36
  • 42 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 13 (a)
(Mus musculus)
Mammalia Gm21119 36
  • 21 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 6 (a)
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
(Gallus gallus)
Aves -- 36
  • 11 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
(Danio rerio)
Actinopterygii ANKRD7 36
  • 6 (a)
Species with no ortholog for POTED:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POTED Gene

Gene Tree for POTED (if available)
Gene Tree for POTED (if available)

Paralogs for POTED Gene

(18) SIMAP similar genes for POTED Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with POTED: view

Variants for POTED Gene

Sequence variations from dbSNP and Humsavar for POTED Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs6517869 - 13,610,565(+) GGAGC(A/G)GCAAG reference, missense
VAR_016243 -
VAR_064765 -
rs2259257 -- 13,629,203(+) AAAAA(A/T)TTTAT intron-variant
rs2261599 -- 13,622,590(+) CAGTG(C/T)CCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POTED Gene

Variant ID Type Subtype PubMed ID
esv2751923 CNV Loss 17911159
dgv1351e1 CNV Complex 17122850
dgv4670n71 CNV Loss 21882294
nsv442489 CNV CNV 18776908
essv5592 CNV CNV 17122850
nsv428383 CNV Loss 18775914
nsv470875 CNV Gain 18288195
nsv470876 CNV Loss 18288195
dgv36n64 CNV Loss 17921354
nsv515654 CNV Gain+Loss 19592680
dgv4673n71 CNV Loss 21882294
dgv1353e1 CNV Complex 17122850
dgv4675n71 CNV Loss 21882294
essv3511 CNV CNV 17122850
nsv469617 CNV Gain 16826518
nsv471708 CNV Loss 15918152
dgv1354e1 CNV Complex 17122850
esv21968 CNV Gain 19812545
nsv828819 CNV Gain 20364138
nsv913380 CNV Loss 21882294
nsv913381 CNV Gain 21882294
dgv803e199 CNV Deletion 23128226
dgv1355e1 CNV Complex 17122850
nsv834044 CNV Gain+Loss 17160897
nsv828821 CNV Gain 20364138
nsv512633 CNV Loss 21212237
nsv9849 CNV Gain+Loss 18304495
esv2674621 CNV Deletion 23128226
nsv913382 CNV Gain 21882294

Variation tolerance for POTED Gene

Gene Damage Index Score: 2.92; 48.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for POTED Gene

Disorders for POTED Gene

Relevant External Links for POTED

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for POTED Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POTED Gene

Publications for POTED Gene

  1. Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. (PMID: 15276201) Bera T.K. … Pastan I. (Gene 2004) 2 3 4 67
  2. Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. (PMID: 16364570) Hahn Y. … Lee B. (Gene 2006) 2 3 23
  3. POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. (PMID: 12475935) Bera T.K. … Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. POTE protein, a cancer-testis antigen, is highly expressed in spermatids in human testis and is associated with apoptotic cells. (PMID: 22234308) Bera T.K. … Pastan I. (Biochem. Biophys. Res. Commun. 2012) 3
  5. Expression of POTE protein in human testis detected by novel monoclonal antibodies. (PMID: 17996727) Ise T. … Pastan I. (Biochem. Biophys. Res. Commun. 2008) 3

Products for POTED Gene

Sources for POTED Gene