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POTED Gene

protein-coding   GIFtS: 39
GCID: GC21P014982

POTE Ankyrin Domain Family, Member D

(Previous names: ankyrin repeat domain 21, ANKRD26-like family B, member...)
(Previous symbols: ANKRD21, A26B3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
POTE Ankyrin Domain Family, Member D1 2     Cancer/Testis Antigen Family 1041
ANKRD211 2 3 5     Member 11
A26B31 2 3     CT104.12
POTE2 3 5     POTE-212
ANKRD26-Like Family B, Member 31 2     POTE212
Ankyrin Repeat Domain 211 2     Cancer/Testis Antigen Family 104, Member 12
Ankyrin Repeat Domain-Containing Protein 212 3     Expressed In Prostate, Ovary, Testis, And Placenta2
Prostate, Ovary, Testis-Expressed Protein2 3     POTE Ankyrin Domain Family Member D2
ANKRD26-Like Family B Member 32 3     Protein POTE3

External Ids:    HGNC: 238221   Entrez Gene: 3177542   Ensembl: ENSG000001663517   OMIM: 6075495   UniProtKB: Q86YR63   

Export aliases for POTED gene to outside databases

Previous GC identifer: GC21P013910


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for POTED Gene:
POTED (POTE ankyrin domain family, member D) is a protein-coding gene. Diseases associated with POTED include prostatitis, and prostate cancer. An important paralog of this gene is POTEF.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the POTED gene promoter:
         Oct-B1   POU2F2 (Oct-2.1)   oct-B2   oct-B3   Nkx2-2   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOTED promoter sequence
   Search Chromatin IP Primers for POTED

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POTED


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q11.2   Ensembl cytogenetic band:  21q11.2   HGNC cytogenetic band: 21q11.2

POTED Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POTED gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P014982:  view genomic region     (about GC identifiers)

Start:
14,982,498 bp from pter      End:
15,013,906 bp from pter
Size:
31,409 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: POTED_HUMAN, Q86YR6 (See protein sequence)
Recommended Name: POTE ankyrin domain family member D  
Size: 584 amino acids; 66394 Da
Secondary accessions: C9JCF7

Explore the universe of human proteins at neXtProt for POTED: NX_Q86YR6

Explore proteomics data for POTED at MOPED


See POTED Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_778146.2  
ENSEMBL proteins: 
 ENSP00000299443  

POTED Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
POTE: POTE ankyrin domain containing
ANKRD: Ankyrin repeat domain containing

2 InterPro protein domains:
 IPR002110 Ankyrin_rpt
 IPR020683 Ankyrin_rpt-contain_dom

Graphical View of Domain Structure for InterPro Entry Q86YR6

ProtoNet protein and cluster: Q86YR6

1 Blocks protein domain: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: POTED_HUMAN, Q86YR6
Similarity: Belongs to the POTE family
Similarity: Contains 6 ANK repeats


POTED for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
POTED for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for POTED:
 Decreased viability with pacli 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
POTED_HUMAN, Q86YR6: Cell membrane; Peripheral membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
cytosol2
nucleus2
cytoskeleton1
endoplasmic reticulum1
extracellular1
mitochondrion1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--

POTED for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POTED
Interactions:

    Search GeneGlobe Interaction Network for POTED

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

Selected Interacting proteins for POTED (ENSP000002994434) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
InteractantInteraction Details
GeneCardExternal ID(s)
ZNHIT1ENSP000003045934STRING: ENSP00000304593
ACTR5ENSP000002439034STRING: ENSP00000243903
ACTR8ENSP000003368424STRING: ENSP00000336842
VPS72ENSP000003578874STRING: ENSP00000357887
LCP1ENSP000003157574STRING: ENSP00000315757
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for POTED



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for POTED gene: 
NM_174981.3  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000299443(uc002yjb.1)
miRNA
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  QuantiFast Probe-based Assays in human, mouse, rat POTED

2 AceView cDNA sequences:

AY172978 NM_174981 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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POTED expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
POTED Expression
About this image

POTED Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

POTED Protein Expression

UniProtKB/Swiss-Prot: POTED_HUMAN, Q86YR6
Tissue specificity: Expressed in prostate, ovary, testis, placenta and prostate cancer cell lines. Localizes to
basal and terminal prostate epithelial cells

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POTED

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for POTED gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
11(a)
1 → many
1(24064036-24111623)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
36(a)
many ↔ many
GL344195.1(38786-58936)
zebrafish
(Danio rerio)
Actinopterygii ANKRD76
ankyrin repeat domain 7
6(a)
1 → many
25(3581527-3655709) ENSDARG00000013015
        Species with no ortholog for POTED

ENSEMBL Gene Tree for POTED (if available)
TreeFam Gene Tree for POTED (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for POTED gene
LOC1002889661 2  POTEF2  POTEI2  ANKRD30A2  POTEB22  ANKRD362  ANKRD72  POTEB2  
ANKRD30BL2  ANKRD20A32  POTEH2  ANKRD30B2  LOC6442492  ENSG000002663022  ANKRD36C2  POTEJ2  
POTEC2  ANKRD20A22  ANKRD262  POTEG2  ANKRD622  ANKRD18A2  POTEM2  ANKRD20A12  
CCDC144A2  POTEE2  ANKRD20A42  ANKRD18B2  
18 SIMAP similar genes for POTED using alignment to 1 protein entry:     POTED_HUMAN:
POTEC    POTEG    POTEM    POTEB    POTEB2    POTEH
POTEF    POTEA    ANKRD30BL    ANKRD19P    POTEE    POTEI
ANKRD36BP1    POTEJ    ANKRD62    ANKRD20A1    ANKRD20A2    ANKRD20A4

POTED for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for POTED (see all 443)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 21 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1176348501,2
C,F--14980586(+) TAGCCT/CGGTAA 1 -- us2k11Minor allele frequency- C:0.32NA 120
rs1144527141,2
C--14980615(+) CACCAA/GTTCTT 1 -- us2k10--------
rs799677541,2
C--14980622(+) TCTTAA/TCAACA 1 -- us2k10--------
rs2016872631,2
C--14980683(+) GTGACA/GTTTAC 1 -- us2k10--------
rs1402402221,2
C--14980907(+) TGTCGC/TCCAGG 1 -- us2k10--------
rs1487233151,2
C--14981130(+) ATTACA/TGGCGT 1 -- us2k10--------
rs2009310651,2
C--14981139(+) GTGAGC/TCACAG 1 -- us2k10--------
rs1441234011,2
C--14981206(+) GCAGCC/TTGGAG 1 -- us2k10--------
rs1411024081,2
--14981305(+) GGCTCC/TGATCT 1 -- us2k10--------
rs1501706241,2
C--14981333(+) AGTGTA/CCTGTT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for POTED (14982498 - 15013906 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for POTED (see all 29):    About this table    
Variant IDTypeSubtypePubMed ID
dgv803e199CNV Deletion23128226
esv2674621CNV Deletion23128226
nsv512633CNV Loss21212237
nsv471708CNV Loss15918152
nsv428383CNV Loss18775914
nsv470876CNV Loss18288195
dgv4675n71CNV Loss21882294
esv2751923CNV Loss17911159
dgv4670n71CNV Loss21882294
dgv4673n71CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing POTED
DNA2.0 Custom Variant and Variant Library Synthesis for POTED

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607549    OMIM disorders: --

2 diseases for POTED:    About MalaCards
prostatitis    prostate cancer


POTED for disorders           About GeneDecksing


Export disorders for POTED gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for POTED gene integrated from 10 sources:
(articles sorted by number of sources associating them with POTED)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. (PubMed id 15276201)1, 2, 3 Bera T.K.... Pastan I. (Gene 2004)
  2. POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. (PubMed id 12475935)1, 2, 3 Bera T.K.... Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  3. Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. (PubMed id 16364570)1, 3, 9 Hahn Y.... Lee B. (Gene 2006)
  4. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
  5. POTE protein, a cancer-testis antigen, is highly expressed in spermatids in human testis and is associated with apoptotic cells. (PubMed id 22234308)1 Bera T.K....Pastan I. (Biochem. Biophys. Res. Commun. 2012)
  6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
  7. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (Nature 2011)
  8. Expression of POTE protein in human testis detected by novel monoclonal antibodies. (PubMed id 17996727)1 Ise T....Pastan I. (Biochem. Biophys. Res. Commun. 2008)
  9. Palmitoylation of POTE family proteins for plasma membrane targeting. (PubMed id 17904529)9 Das S....Pastan I. (Biochem. Biophys. Res. Commun. 2007)
  10. Identification of the putrescine recognition site on polyamine transport protein PotE. (PubMed id 10964926)9 Kashiwagi K....Igarashi K. (J. Biol. Chem. 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 317754 HGNC: 23822 AceView: ANKRD21 Ensembl:ENSG00000166351 euGenes: HUgn317754
ECgene: POTED H-InvDB: POTED

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for POTED Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for POTED gene:
Search GeneIP for patents involving POTED

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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 Search for Antibodies for POTED at Abcam
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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POTED
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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