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Aliases for POTED Gene

Aliases for POTED Gene

  • POTE Ankyrin Domain Family Member D 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 21 3 4
  • Cancer/Testis Antigen Family 104, Member 1 2 3
  • Prostate, Ovary, Testis-Expressed Protein 3 4
  • ANKRD26-Like Family B Member 3 3 4
  • Ankyrin Repeat Domain 21 2 3
  • ANKRD21 3 4
  • A26B3 3 4
  • POTE 3 4
  • Expressed In Prostate, Ovary, Testis, And Placenta 3
  • POTE Ankyrin Domain Family, Member D 2
  • ANKRD26-Like Family B, Member 3 2
  • Protein POTE 4
  • CT104.1 3
  • POTE-21 3
  • POTE21 3

External Ids for POTED Gene

Previous HGNC Symbols for POTED Gene

  • ANKRD21
  • A26B3

Previous GeneCards Identifiers for POTED Gene

  • GC21P013910
  • GC21P014982

Summaries for POTED Gene

GeneCards Summary for POTED Gene

POTED (POTE Ankyrin Domain Family Member D) is a Protein Coding gene. An important paralog of this gene is LOC100288966.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POTED Gene

Genomics for POTED Gene

Regulatory Elements for POTED Gene


Genomic Location for POTED Gene

Chromosome:
21
Start:
13,609,858 bp from pter
End:
13,641,585 bp from pter
Size:
31,728 bases
Orientation:
Plus strand

Genomic View for POTED Gene

Genes around POTED on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POTED Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POTED Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POTED Gene

Proteins for POTED Gene

  • Protein details for POTED Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YR6-POTED_HUMAN
    Recommended name:
    POTE ankyrin domain family member D
    Protein Accession:
    Q86YR6
    Secondary Accessions:
    • C9JCF7

    Protein attributes for POTED Gene

    Size:
    584 amino acids
    Molecular mass:
    66394 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POTED Gene

Post-translational modifications for POTED Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POTED Gene

No data available for DME Specific Peptides for POTED Gene

Domains & Families for POTED Gene

Protein Domains for POTED Gene

Suggested Antigen Peptide Sequences for POTED Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YR6

UniProtKB/Swiss-Prot:

POTED_HUMAN :
  • Belongs to the POTE family.
  • Contains 6 ANK repeats.
Family:
  • Belongs to the POTE family.
Similarity:
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with POTED: view

Function for POTED Gene

genes like me logo Genes that share phenotypes with POTED: view

Animal Model Products

miRNA for POTED Gene

miRTarBase miRNAs that target POTED

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POTED Gene

Localization for POTED Gene

Subcellular locations from UniProtKB/Swiss-Prot for POTED Gene

Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POTED Gene COMPARTMENTS Subcellular localization image for POTED gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for POTED Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with POTED: view

Pathways & Interactions for POTED Gene

SuperPathways for POTED Gene

No Data Available

Gene Ontology (GO) - Biological Process for POTED Gene

None

No data available for Pathways by source and SIGNOR curated interactions for POTED Gene

Transcripts for POTED Gene

mRNA/cDNA for POTED Gene

(3) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POTED Gene

No ASD Table

Relevant External Links for POTED Gene

GeneLoc Exon Structure for
POTED
ECgene alternative splicing isoforms for
POTED

Expression for POTED Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POTED Gene

mRNA differential expression in normal tissues according to GTEx for POTED Gene

This gene is overexpressed in Testis (x52.9).

Protein differential expression in normal tissues from HIPED for POTED Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POTED Gene



Protein tissue co-expression partners for POTED Gene

NURSA nuclear receptor signaling pathways regulating expression of POTED Gene:

POTED

mRNA Expression by UniProt/SwissProt for POTED Gene:

Q86YR6-POTED_HUMAN
Tissue specificity: Expressed in prostate, ovary, testis, placenta and prostate cancer cell lines. Localizes to basal and terminal prostate epithelial cells.
genes like me logo Genes that share expression patterns with POTED: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for POTED Gene

Orthologs for POTED Gene

This gene was present in the common ancestor of chordates.

Orthologs for POTED Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 42 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 12 (a)
ManyToMany
-- 35
  • 9 (a)
ManyToMany
-- 35
  • 7 (a)
ManyToMany
-- 35
  • 6 (a)
ManyToMany
-- 35
  • 6 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm21119 35
  • 21 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 13 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 6 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 6 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 11 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 36 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ANKRD7 35
  • 6 (a)
OneToMany
Species where no ortholog for POTED was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POTED Gene

ENSEMBL:
Gene Tree for POTED (if available)
TreeFam:
Gene Tree for POTED (if available)

Paralogs for POTED Gene

Variants for POTED Gene

Sequence variations from dbSNP and Humsavar for POTED Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs10222155 -- 13,641,956(+) cgtgc(A/G)ggctt downstream-variant-500B
rs111402716 -- 13,628,533(+) GAAAT(C/T)ACCTT intron-variant
rs111535105 -- 13,630,433(+) GATCA(A/G)AGGCA intron-variant
rs111562312 -- 13,609,980(+) TCGGA(-/G)GGGGG upstream-variant-2KB
rs111576507 -- 13,640,414(+) AAAGG(C/T)TTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POTED Gene

Variant ID Type Subtype PubMed ID
dgv2359n106 CNV deletion 24896259
dgv2470e59 CNV duplication 20981092
dgv2471e59 CNV duplication 20981092
dgv36n64 CNV loss 17921354
dgv4377n100 CNV gain 25217958
dgv4378n100 CNV gain 25217958
dgv4379n100 CNV loss 25217958
dgv4381n100 CNV loss 25217958
dgv4382n100 CNV gain 25217958
dgv4383n100 CNV gain+loss 25217958
dgv4384n100 CNV gain 25217958
dgv4385n100 CNV gain 25217958
dgv4386n100 CNV gain 25217958
dgv4387n100 CNV gain 25217958
dgv7751n54 CNV gain 21841781
dgv7753n54 CNV loss 21841781
dgv7756n54 CNV loss 21841781
dgv7757n54 CNV gain 21841781
dgv803e199 CNV deletion 23128226
dgv93e203 CNV gain+loss 21179565
esv21968 CNV gain 19812545
esv2674621 CNV deletion 23128226
esv2751923 CNV loss 17911159
esv2758809 CNV gain+loss 17122850
esv3366121 CNV duplication 20981092
esv3373409 CNV duplication 20981092
esv3391843 CNV duplication 20981092
esv3404908 CNV duplication 20981092
esv3568102 CNV loss 25503493
esv3568103 CNV loss 25503493
esv3568104 CNV loss 25503493
esv3575379 CNV gain 25503493
esv3646398 CNV loss 21293372
esv3893364 CNV gain+loss 25118596
esv3893367 CNV gain 25118596
nsv1056086 CNV loss 25217958
nsv1056303 CNV gain 25217958
nsv1057704 CNV loss 25217958
nsv1058202 CNV loss 25217958
nsv1059711 CNV gain 25217958
nsv1062730 CNV loss 25217958
nsv1073113 CNV deletion 25765185
nsv428383 CNV loss 18775914
nsv442489 CNV loss 18776908
nsv469617 CNV gain 16826518
nsv470875 CNV gain 18288195
nsv470876 CNV loss 18288195
nsv471708 CNV loss 15918152
nsv512633 CNV loss 21212237
nsv515654 CNV gain+loss 19592680
nsv586992 CNV gain 21841781
nsv587001 CNV loss 21841781
nsv587012 CNV loss 21841781
nsv587013 CNV loss 21841781
nsv587014 CNV loss 21841781
nsv828819 CNV gain 20364138
nsv828821 CNV gain 20364138
nsv834044 CNV gain+loss 17160897
nsv965993 CNV duplication 23825009
nsv979521 CNV duplication 23825009
nsv9849 CNV gain+loss 18304495

Variation tolerance for POTED Gene

Gene Damage Index Score: 2.92; 48.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POTED Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POTED

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POTED Gene

Disorders for POTED Gene

Relevant External Links for POTED

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POTED

No disorders were found for POTED Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POTED Gene

Publications for POTED Gene

  1. Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. (PMID: 16364570) Hahn Y. … Lee B. (Gene 2006) 2 3 22 64
  2. Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. (PMID: 15276201) Bera T.K. … Pastan I. (Gene 2004) 2 3 4 64
  3. POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. (PMID: 12475935) Bera T.K. … Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 64
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4 64
  5. POTE protein, a cancer-testis antigen, is highly expressed in spermatids in human testis and is associated with apoptotic cells. (PMID: 22234308) Bera T.K. … Pastan I. (Biochem. Biophys. Res. Commun. 2012) 3 64

Products for POTED Gene

Sources for POTED Gene

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