POTED Gene
protein-coding GIFtS: 38
GCID: GC21P014982
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POTE ankyrin domain family, member D(Previous names: ankyrin repeat domain 21, ANKRD26-like family B, member...)
(Previous symbols: ANKRD21, A26B3)
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Aliases
for POTED gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| POTE Ankyrin Domain Family, Member D1 2 | | Ankyrin Repeat Domain 211 2 | | ANKRD211 2 3 5 | | Ankyrin Repeat Domain-Containing Protein 212 3 | | POTE1 2 3 5 | | Prostate, Ovary, Testis-Expressed Protein2 3 | | A26B31 2 3 | | ANKRD26-Like Family B Member 32 3 | | CT104.11 2 | | Cancer/Testis Antigen Family 104, Member 12 | | POTE-211 2 | | Expressed In Prostate, Ovary, Testis, And Placenta2 | | POTE211 2 | | POTE Ankyrin Domain Family Member D2 | | ANKRD26-Like Family B, Member 31 2 | | Protein POTE3 |
Export aliases for POTED gene to outside databasesPrevious GC identifer: GC21P013910 |
Summaries
for POTED gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for POTED gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the POTED gene promoter:
Oct-B1 POU2F2 (Oct-2.1) oct-B2 oct-B3 Nkx2-2 POU2F2 POU2F2C POU2F1 POU2F1a POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for POTED
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POTED |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21q11.2 Ensembl cytogenetic band: 21q11.2 HGNC cytogenetic band: 21q11.2POTED Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21P014982: view genomic region
(about GC identifiers)
Start:
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14,982,498 bp from pter |
End:
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15,013,906 bp from pter |
Size:
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31,409 bases |
Orientation:
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plus strand |
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Proteins
for POTED gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: POTED_HUMAN, Q86YR6 (See
protein sequence)Recommended Name: POTE ankyrin domain family member D Size: 584 amino acids; 66394 Da
Subcellular location: Cell membrane; Peripheral membrane protein
Secondary accessions: C9JCF7Explore the universe of human proteins at neXtProt for POTED: NX_Q86YR6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86YR6
POTED Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_778146.2
ENSEMBL proteins: ENSP00000299443
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- |
POTED for ontologies About GeneDecksing
POTED Antibody Products:
Assay Products for POTED: |
Protein
Domains /
Families
for POTED gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
POTED for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86YR6ProtoNet protein and cluster: Q86YR6 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: POTED_HUMAN, Q86YR6Similarity: Belongs to the POTE familySimilarity: Contains 6 ANK repeats |
Function
for POTED gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POTED
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POTED
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: POTED (NM_174981) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POTED | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POTED |
1 GenomeRNAi human phenotype for POTED:
|
Pathways & Interactions
for POTED gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POTED
|
Drugs & Compounds
for POTED gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for POTED
Search CenterWatch for drugs/clinical trials and news about POTED
|
Transcripts
for POTED gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for POTED gene: NM_174981.3 1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000299443(uc002yjb.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POTED
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POTED
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: POTED (NM_174981) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POTED | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POTED |
2 AceView cDNA sequences: NM_174981 AY172978
GeneLoc Exon Structure
|
Expression
for POTED gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| POTED expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See POTED Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POTED
UniProtKB/Swiss-Prot: POTED_HUMAN, Q86YR6Tissue specificity: Expressed in prostate, ovary, testis, placenta and prostate cancer cell lines. Localizes to basaland terminal prostate epithelial cells
SABiosciences Custom PCR Arrays for POTED
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POTED
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat POTED | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POTED | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POTED |
Orthologs
for POTED gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for POTED gene from 3/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ANKRD626 |
Uncharacterized protein |
14(a) |
1 → many |
1(26091172-26138404) |
lizard
(Anolis carolinensis) |
Reptilia |
ANKRD626 |
-- |
35(a) |
1 → many |
GL344195.1(39104-48393) |
zebrafish
(Danio rerio) |
Actinopterygii |
si:ch211-272n13.36 |
si:ch211-272n13.3 |
5(a) |
1 → many |
25(3581527-3655709) |
ENSEMBL Gene Tree for POTED (if available)
TreeFam Gene Tree for POTED (if available) |
Paralogs
for POTED gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for POTED gene
- POTEF2 POTEI2 ANKRD30A2 ANKRD362 ANKRD72 POTEB2 ANKRD30BL2 ANKRD20A32
- POTEH2 ENSG000001552822 ANKRD30B2 ENSG000002663022 ANKRD36C2 POTEJ2 POTEC2 ANKRD20A22
- POTEG2 ANKRD262 ANKRD622 ANKRD18A2 ENSG000001882192 POTEM2 ANKRD20A12 LOC1009963312
- CCDC144A2 ANKRD20A42 ANKRD18B2 LOC1002889662
17 SIMAP similar genes for POTED using alignment to 1 protein entry: POTED_HUMAN:POTEC POTEG POTEM POTEB POTEH POTEF
POTEA ANKRD30BL ANKRD19P POTEE POTEI ANKRD36BP1
POTEJ ANKRD62 ANKRD20A1 ANKRD20A2 ANKRD20A4
POTED for paralogs About GeneDecksing
|
Genomic Variants
for POTED gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for POTED (14982498 - 15013906 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 16 variations for POTED
15/16 CNVs (see all 16): 73606 32439 2255 9322 90695 50729 50731 3225 5157 10591 38448 0811 8890 4110 50730 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POTED |
|
Disorders
/ Diseases
for POTED gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
POTED for disorders About GeneDecksing
OMIM gene information: 607549
OMIM disorders: --
2  diseases for POTED: About MalaCardsprostatitis prostate cancer
Export disorders for POTED gene to outside databases
|
Publications
for POTED gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for POTED gene integrated from 9 sources:
(articles sorted by number of sources associating them with POTED) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. (PubMed id 15276201)1, 2, 3 Bera T.K.... Pastan I. (2004)
- POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. (PubMed id 12475935)1, 2, 3 Bera T.K.... Pastan I. (2002)
- Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. (PubMed id 16364570)1, 3, 9 Hahn Y.... Lee B. (2006)
- The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
- POTE protein, a cancer-testis antigen, is highly expre ssed in spermatids in human testis and is associated with apoptotic cells. (PubMed id 22234308)1 Bera T.K....Pastan I. (2012)
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
- Expression of POTE protein in human testis detected by novel monoclonal antibodies. (PubMed id 17996727)1 Ise T....Pastan I. (2008)
- Palmitoylation of POTE family proteins for plasma membrane targeting. (PubMed id 17904529)9 Das S....Pastan I. (2007)
- Identification of the putrescine recognition site on polyamine transport protein PotE. (PubMed id 10964926)9 Kashiwagi K....Igarashi K. (2000)
|
External Searches for POTED gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing POTED gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing POTED gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing POTED gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for POTED | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for POTED gene:
Search GeneIP for patents involving POTED
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for POTED gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for POTED | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POTED | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POTED | | | OriGene Protein Over-expression Lysate for POTED | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for POTED | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POTED | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POTED | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for POTED | | OriGene Custom Protein Services for POTED | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POTED | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POTED | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POTED | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POTED | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POTED | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POTED |
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 |  |  |  | |
| | | | Search Tocris compounds for POTED |
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 | | | POTED Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for POTED |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POTED |
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