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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POSTN Gene

protein-coding   GIFtS: 61
GCID: GC13M038136

Periostin, Osteoblast Specific Factor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Periostin, Osteoblast Specific Factor1 2     Osteoblast Specific Factor 2 (Fasciclin I-Like)2
OSF22 3 5     Periodontal Ligament-Specific Periostin2
PN2 3 5     periostin2
Osteoblast-Specific Factor 22 3     Periostin Isoform Thy22
OSF-22 3     Periostin Isoform Thy42
PDLPOSTN2     Periostin Isoform Thy62
RP11-412K4.12     Periostin Isoform Thy82

External Ids:    HGNC: 169531   Entrez Gene: 106312   Ensembl: ENSG000001331107   OMIM: 6087775   UniProtKB: Q150633   

Export aliases for POSTN gene to outside databases

Previous GC identifers: GC13M035934 GC13M037034 GC13M018936


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for POSTN Gene: 
POSTN (periostin, osteoblast specific factor) is a protein-coding gene. Diseases associated with POSTN include melorheostosis, and peyronie's disease. GO annotations related to this gene include heparin binding. An important paralog of this gene is TGFBI.

UniProtKB/Swiss-Prot: POSTN_HUMAN, Q15063
Function: Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent
proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a
role in cell adhesion. May play a role in extracellular matrix mineralization

Gene Wiki entry for POSTN (Periostin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POSTN gene promoter:
         LHX3b/Lhx3b   GATA-3   Nkx2-2   Lmo2   Evi-1   SRY   E2F-1   E2F   HOXA5   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOSTN promoter sequence
   Search SABiosciences Chromatin IP Primers for POSTN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POSTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.3   Ensembl cytogenetic band:  13q13.3   HGNC cytogenetic band: 13q13.3

POSTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POSTN gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M038136:  view genomic region     (about GC identifiers)

Start:
38,136,719 bp from pter      End:
38,172,981 bp from pter
Size:
36,263 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: POSTN_HUMAN, Q15063 (See protein sequence)
Recommended Name: Periostin precursor  
Size: 836 amino acids; 93314 Da
Subunit: Interacts with BMP1 and fibronectin (By similarity)
Subcellular location: Golgi apparatus (By similarity). Secreted, extracellular space, extracellular matrix.
Note=Co-localizes with BMP1 in the Golgi (By similarity)
Secondary accessions: Q15064 Q29XZ0 Q3KPJ5 Q5VSY5 Q8IZF9
Alternative splicing: 4 isoforms:  Q15063-1   Q15063-2   Q15063-3   Q15063-4   

Explore the universe of human proteins at neXtProt for POSTN: NX_Q15063

Explore proteomics data for POSTN at MOPED 

Post-translational modifications:

  • UniProtKB: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for
    the binding of calcium
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15063

  • POSTN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    POSTN Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001129406.1  NP_001129407.1  NP_001129408.1  NP_006466.2  

    ENSEMBL proteins: 
     ENSP00000369073   ENSP00000369071   ENSP00000369067   ENSP00000369066   ENSP00000437959  
     ENSP00000437953  

    Human Recombinant Protein Products for POSTN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for POSTN (Periostin/OSF-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for POSTN
    OriGene Protein Over-expression Lysate for POSTN
    OriGene MassSpec for POSTN 
    OriGene Custom Protein Services for POSTN
    GenScript Custom Purified and Recombinant Proteins Services for POSTN
    Novus Biologicals POSTN Lysate
    Sino Biological Recombinant Protein for POSTN
    Sino Biological Cell Lysate for POSTN 
    ProSpec Recombinant Protein for POSTN
    Cloud-Clone Corp. Proteins for POSTN 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix ISS--
    GO:0005794Golgi apparatus IEA--
    GO:0031012colocalizes with extracellular matrix IDA--

    POSTN for ontologies           About GeneDecksing



    POSTN Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of POSTN
    R&D Systems Antibodies for POSTN (Periostin/OSF-2)
    OriGene Antibodies for POSTN
    OriGene Custom Antibody Services for POSTN
    GenScript Custom Superior Antibodies Services for POSTN
    Novus Biologicals POSTN Antibodies
    Abcam antibodies for POSTN
    Cloud-Clone Corp. Antibodies for POSTN 
    Search ThermoFisher Antibodies for POSTN
    LSBio Antibodies in human, mouse, rat for POSTN 

    Assay Products for POSTN: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for POSTN
    R&D Systems ELISAs for POSTN (Periostin/OSF-2)         (see all)
    GenScript Custom Assay Services for POSTN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for POSTN 
    Cloud-Clone Corp. CLIAs for POSTN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011489 EMI_domain
     IPR016666 TGFb-ind_bIGH3/osteoblast_fac2
     IPR000782 FAS1_domain

    Graphical View of Domain Structure for InterPro Entry Q15063

    ProtoNet protein and cluster: Q15063

    2 Blocks protein domains:
    IPB000782 Beta-Ig-H3/Fasciclin domain
    IPB011489 EMI


    UniProtKB/Swiss-Prot: POSTN_HUMAN, Q15063
    Similarity: Contains 1 EMI domain
    Similarity: Contains 4 FAS1 domains


    POSTN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: POSTN_HUMAN, Q15063
    Function: Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent
    proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a
    role in cell adhesion. May play a role in extracellular matrix mineralization

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008201heparin binding ISS--
         
    POSTN for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Postn):
     cardiovascular system  cellular  craniofacial  endocrine/exocrine gland  growth/size 
     homeostasis/metabolism  immune system  limbs/digits/tail  mortality/aging  muscle 
     reproductive system  skeleton  tumorigenesis 

    POSTN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for POSTN: Postntm1Kudo Postntm1Jmol

       inGenious Targeting Laboratory - Custom generated mouse model solutions for POSTN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POSTN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POSTN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POSTN 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POSTN
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate POSTN (see all 9):
    hsa-miR-142-5p hsa-miR-183* hsa-miR-19b hsa-miR-202 hsa-miR-561 hsa-miR-32* hsa-miR-340 hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidPOSTN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for POSTN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POSTN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for POSTN
    Sirion Biotech Customized adenovirus for overexpression of POSTN

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for POSTN (see all 22)
    OriGene ORF clones in mouse, rat for POSTN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): POSTN (NM_006475)
    Sino Biological Human cDNA Clone for POSTN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POSTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POSTN
    Sirion Biotech Customized lentivirus for stable overexpression of POSTN 
                         Customized lentivirus expression plasmids for stable overexpression of POSTN 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for POSTN
    LifeMap BioReagents: cell lines associated with POSTN: PureStem 4D20.8, NCr-fac Progenitor,
    PureStem 7SMOO32, NCr-fac & Meso Progenitor, PureStem E15, Meso-prx/latp Progenitor,
    PureStem ES-210, Ecto-ntu Progenitor, PureStem MEL2, NCr-fac Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POSTN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POSTN

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for POSTN (Q150632, 3 ENSP000003690714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAPPC2LQ9UL332, 3, ENSP000003010214MINT-8201496 I2D: score=1 STRING: ENSP00000301021
    TLE1ENSP000003656824STRING: ENSP00000365682
    --Q9CQP22MINT-8201482
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS8363580
    GO:0007155cell adhesion IDA12235007
    GO:0008593regulation of Notch signaling pathway IEA--
    GO:0009888tissue development IEA--
    GO:0030198extracellular matrix organization IEA--

    POSTN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    POSTN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POSTN

    1 HMDB Compound for POSTN    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for POSTN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 0 1 17014703 (1)
    vegf 0 3 19412434 (1), 16979964 (1)

    Search CenterWatch for drugs/clinical trials and news about POSTN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POSTN gene (4 alternative transcripts): 
    NM_001135934.1  NM_001135935.1  NM_001135936.1  NM_006475.2  

    Unigene Clusters for POSTN:

    Periostin, osteoblast specific factor
    Hs.136348  [show with all ESTs], Hs.721018  [show with all ESTs]
    Unigene Representative Sequences: NM_006475, AK021444
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379749 ENST00000379747(uc010tet.2 uc001uwo.4 uc001uwp.4 uc010teu.1 uc010tev.1)
    ENST00000379743 ENST00000379742 ENST00000478947 ENST00000473823 ENST00000474646
    ENST00000497145 ENST00000541179(uc001uwr.3 uc001uwq.3 uc010tew.1)
    ENST00000541481(uc010tex.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POSTN
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate POSTN (see all 9):
    hsa-miR-142-5p hsa-miR-183* hsa-miR-19b hsa-miR-202 hsa-miR-561 hsa-miR-32* hsa-miR-340 hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidPOSTN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for POSTN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POSTN
    Clone
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    OriGene clones in human, mouse for POSTN (see all 22)
    OriGene ORF clones in mouse, rat for POSTN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): POSTN (NM_006475)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POSTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POSTN
    Sirion Biotech Customized lentivirus for stable overexpression of POSTN 
                         Customized lentivirus expression plasmids for stable overexpression of POSTN 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for POSTN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POSTN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POSTN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POSTN

    Additional mRNA sequence: AK021444.1 

    19 DOTS entries:

    DT.455851  DT.92455521  DT.95130883  DT.100786679  DT.40290028  DT.95074198  DT.438562  DT.95311906 
    DT.95218519  DT.95218517  DT.102842890  DT.120768687  DT.120768695  DT.65285802  DT.100786683  DT.440146 
    DT.99934594  DT.120768694  DT.422386 

    24/395 AceView cDNA sequences (see all 395):

    BP336541 AI676202 AU119903 AA599197 BI916613 BI711202 AW043552 AI829430 
    BM722587 AA598653 AU139611 AW085816 AA775603 BQ270472 AA903223 AI262129 
    AI985893 AU117842 BM876518 AY140646 AI953065 BM679041 AA129960 AI493643 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for POSTN (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20a · 20b ^
    SP1:                                                                                                              -                 -                 -         
    SP2:                                                                                                        -     -     -     -     -                 -         
    SP3:                                                                                                        -     -                 -                 -         
    SP4:                                                                                                        -     -     -     -     -                 -         
    SP5:                                                                                                        -     -     -     -     -     -     -     -         

    ExUns: 21a · 21b ^ 22 ^ 23a · 23b · 23c · 23d
    SP1:        -                                 
    SP2:        -                                 
    SP3:                                          
    SP4:  -     -                                 
    SP5:  -     -                                 


    ECgene alternative splicing isoforms for POSTN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POSTN expression in normal human tissues (normalized intensities)      POSTN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAGCTAAG
    POSTN Expression
    About this image


    POSTN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/41 selected tissues (see all 41) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 20 entries
             Endochondral Preosteoblasts Caudal Endochondral Bones
             Thoracic Rib
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
             Normal Human osteoblasts (NHOST)   
     
     Heart (Cardiovascular System)    fully expand to see all 11 entries
             Cardiac Fibroblasts Myocardium
             Coronary Vessels
             Coronary Artery Smooth Muscle Cells (CASMC)   
             heart/valve/pulmonary valve   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 11 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
             Knee Normal Human Articular chondrocytes (knNHAC)   
     
     Fibroblast
             Detroit 551
             skin ; fibroblasts   
     
     Uncategorized (Uncategorized)    fully expand to see all 6 entries
             PureStem Progenitor E72

    See POSTN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POSTN

    SOURCE GeneReport for Unigene clusters: Hs.136348 Hs.721018

    UniProtKB/Swiss-Prot: POSTN_HUMAN, Q15063
    Tissue specificity: Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract,
    placenta, uterus and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also
    highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in
    breast cancers

        SABiosciences Expression via Pathway-Focused PCR Arrays including POSTN: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cardiotoxicity in human mouse rat
              Allergy & Asthma in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for POSTN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POSTN
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POSTN
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POSTN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POSTN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for POSTN gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Postn1 , 5 periostin, osteoblast specific factor1, 5 85.17(n)1
    89.74(a)1
      3 (25.46 cM)5
    507061  NM_015784.31  NP_056599.11 
     543611095 
    chicken
    (Gallus gallus)
    Aves POSTN1 periostin, osteoblast specific factor 75.02(n)
    78.32(a)
      395429  NM_001030541.1  NP_001025712.1 
    lizard
    (Anolis carolinensis)
    Reptilia POSTN6
    periostin, osteoblast specific factor
    71(a)
    1 ↔ 1
    2(82311375-82394845)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia CF345375.12   -- 80.73(n)    CF345375.1 
    zebrafish
    (Danio rerio)
    Actinopterygii postnb1 periostin, osteoblast specific factor b 60.5(n)
    58.98(a)
      337176  NM_203421.1  NP_981966.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mfas1 midline fasciclin 39.31(n)
    24.69(a)
      41455  NM_176477.1  NP_788654.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F26E4.76
    Protein F26E4.7, isoform a
    18(a)
    1 → many
    I(9774207-9779541)


    ENSEMBL Gene Tree for POSTN (if available)
    TreeFam Gene Tree for POSTN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POSTN gene
    TGFBI2  
    1 SIMAP similar gene for POSTN using alignment to 4 protein entries:     POSTN_HUMAN (see all proteins):
    TGFBI

    POSTN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/819 SNPs in POSTN are shown (see all 819)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58028831,2
    C--38136282(+) GATTC-/TTTTTT 4 -- ds50012Minor allele frequency- T:0.25NA CSA 4
    rs1410745951,2
    --38136469(+) AGAGAC/TGGGTT 4 -- ds50010--------
    rs95763021,2
    C,F,A,H--38136579(+) CGGCCG/ATCTAA 4 -- ds500126Minor allele frequency- A:0.39NS EA NA CSA WA 2770
    rs1902212791,2
    --38136656(+) TGCACA/GTCCTG 4 -- ds50010--------
    rs1824792071,2
    --38136666(+) GCACAC/TGCCTG 4 -- ds50010--------
    rs95479511,2
    C,F,A,H--38136682(+) CCCTGC/AGCTTA 4 -- ds500117Minor allele frequency- A:0.26NS EA WA NA CSA 779
    rs574001501,2
    C,F--38136706(+) GAAAAA/GCTCAA 4 -- ds50016Minor allele frequency- G:0.13WA CSA NA EA 364
    rs67501,2
    C,F,A,H--38136832(-) AAATTG/CAGTAA 4 -- ut31 ese312Minor allele frequency- C:0.05MN NA NS EA 936
    rs1144116401,2
    C,F--38136974(+) AGTAAA/GCCCAC 4 -- ut311Minor allele frequency- G:0.02WA 118
    rs1852282571,2
    --38137061(+) CATGGA/GGAGAT 4 -- ut310--------

    HapMap Linkage Disequilibrium report for POSTN (38136719 - 38172981 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for POSTN:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv34109CNV Loss18971310
    nsv832583CNV Loss17160897
    nsv818956CNV Gain17921354


    Human Gene Mutation Database (HGMD): POSTN
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing POSTN
    DNA2.0 Custom Variant and Variant Library Synthesis for POSTN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608777    OMIM disorders: --

    20/53 diseases for POSTN (see all 53):    About MalaCards
    melorheostosis    peyronie's disease    peyronies disease    periostitis
    fibrous dysplasia    periodontitis    idiopathic interstitial pneumonia    malignant pleural mesothelioma
    bile duct carcinoma    papillary thyroid carcinoma    corneal dystrophy    breast cancer susceptibility
    keloids    pancreatic ductal adenocarcinoma    thymoma    lung adenocarcinoma
    connective tissue disease    pneumonia    oral cancer    myocardial infarction


    POSTN for disorders           About GeneDecksing

    10/17 Novoseek inferred disease relationships for POSTN gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 35.2 39 17060937 (4), 15880581 (4), 19212687 (3), 18086302 (2) (see all 14)
    cancer 31.6 42 17616943 (5), 17408641 (4), 18381746 (3), 18086302 (2) (see all 22)
    pancreatic cancer 29.6 19 18381746 (6), 17043657 (6), 20106105 (1)
    tumors 29.4 79 18086302 (7), 18434370 (4), 15082792 (3), 11509119 (3) (see all 28)
    hnscc 23.9 8 16849536 (4)
    nsclc 19.7 13 18949745 (4), 11509119 (3), 11550156 (2)
    scar 16.1 24 18560459 (3), 17649947 (3)
    calcification 15.8 1 16093362 (1)
    cancer lung 14.3 7 19328625 (4), 19533256 (2), 11509119 (1)
    breast cancer 13.6 15 19524268 (4), 17938160 (3), 15082792 (3), 16807673 (2) (see all 6)

    Genetic Association Database (GAD): POSTN
    Human Genome Epidemiology (HuGE) Navigator: POSTN (9 documents)

    Export disorders for POSTN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POSTN gene, integrated from 9 sources (see all 198):
    (articles sorted by number of sources associating them with POSTN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility. (PubMed id 12235007)1, 2, 3, 9 Gillan L....Chang D.D. (2002)
    2. Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. (PubMed id 8363580)1, 2, 3, 9 Takeshita S.... Amann E. (1993)
    3. Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells. (PubMed id 18450759)1, 2, 9 Coutu D.L....Galipeau J. (2008)
    4. Polymorphisms in the KDR and POSTN genes: association with breast cancer susceptibility and prognosis. (PubMed id 16807673)1, 4, 9 Forsti A....Hemminki K. (2007)
    5. Serum level of the periostin, a homologue of an insect cell adhesion molecule, as a prognostic marker in nonsmall cell lung carcinomas. (PubMed id 11550156)1, 2, 9 Sasaki H.... Chen L.B. (2001)
    6. Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. (PubMed id 15082792)1, 2, 9 Shao R.... Wang X.-F. (2004)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    9. Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (2009)
    10. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10631 HGNC: 16953 AceView: POSTN Ensembl:ENSG00000133110 euGenes: HUgn10631
    ECgene: POSTN H-InvDB: POSTN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POSTN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for POSTN gene:
    Search GeneIP for patents involving POSTN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Proteins for POSTN
     Antibodies for POSTN
     ELISAs for POSTN
     CLIAs for POSTN
     Cell Lines associated with POSTN: PureStem 4D20.8, NCr-fac Progenitor,
    PureStem 7SMOO32, NCr-fac & Meso Progenitor, PureStem E15, Meso-prx/latp Progenitor,
    PureStem ES-210, Ecto-ntu Progenitor, PureStem MEL2, NCr-fac Progenitor
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POSTN
     inGenious Targeting Laboratory - Custom generated mouse model solutions for POSTN
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    Customized:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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