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Aliases for POSTN Gene

Aliases for POSTN Gene

  • Periostin, Osteoblast Specific Factor 2 3
  • OSF2 3 4 6
  • PN 3 4 6
  • OSF-2 3 4
  • Osteoblast Specific Factor 2 (Fasciclin I-Like) 3
  • Periodontal Ligament-Specific Periostin 3
  • Osteoblast-Specific Factor 2 4
  • Periostin 3
  • PDLPOSTN 3

External Ids for POSTN Gene

Summaries for POSTN Gene

GeneCards Summary for POSTN Gene

POSTN (Periostin, Osteoblast Specific Factor) is a Protein Coding gene. Diseases associated with POSTN include hypertensive nephropathy. GO annotations related to this gene include heparin binding. An important paralog of this gene is TGFBI.

UniProtKB/Swiss-Prot for POSTN Gene

  • Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.

Gene Wiki entry for POSTN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POSTN Gene

Genomics for POSTN Gene

Genomic Location for POSTN Gene

Start:
37,562,582 bp from pter
End:
37,598,844 bp from pter
Size:
36,263 bases
Orientation:
Minus strand

Genomic View for POSTN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POSTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POSTN Gene

Regulatory Elements for POSTN Gene

Proteins for POSTN Gene

  • Protein details for POSTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15063-POSTN_HUMAN
    Recommended name:
    Periostin
    Protein Accession:
    Q15063
    Secondary Accessions:
    • B1ALD8
    • C0IMJ1
    • C0IMJ2
    • C0IMJ4
    • D2KRH7
    • F5H628
    • Q15064
    • Q29XZ0
    • Q3KPJ5
    • Q5VSY5
    • Q8IZF9

    Protein attributes for POSTN Gene

    Size:
    836 amino acids
    Molecular mass:
    93314 Da
    Quaternary structure:
    • Interacts with BMP1 and fibronectin.

    Alternative splice isoforms for POSTN Gene

neXtProt entry for POSTN Gene

Proteomics data for POSTN Gene at MOPED

Post-translational modifications for POSTN Gene

  • Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn599

No data available for DME Specific Peptides for POSTN Gene

Domains for POSTN Gene

Protein Domains for POSTN Gene

UniProtKB/Swiss-Prot:

POSTN_HUMAN
Domain:
  • Contains 1 EMI domain.:
    • Q15063
  • Contains 4 FAS1 domains.:
    • Q15063
genes like me logo Genes that share domains with POSTN: view

No data available for Gene Families for POSTN Gene

Function for POSTN Gene

Molecular function for POSTN Gene

UniProtKB/Swiss-Prot Function: Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.

Gene Ontology (GO) - Molecular Function for POSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19478074
GO:0008201 heparin binding ISS --
GO:0050839 cell adhesion molecule binding IBA --
genes like me logo Genes that share ontologies with POSTN: view
genes like me logo Genes that share phenotypes with POSTN: view

Animal Models for POSTN Gene

MGI Knock Outs for POSTN:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for POSTN Gene

Localization for POSTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for POSTN Gene

Golgi apparatus. Secreted, extracellular space, extracellular matrix. Note=Colocalizes with BMP1 in the Golgi. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POSTN Gene COMPARTMENTS Subcellular localization image for POSTN gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 3
golgi apparatus 2
cytosol 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for POSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix ISS --
GO:0005615 extracellular space IBA --
GO:0005802 trans-Golgi network IDA 19478074
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
genes like me logo Genes that share ontologies with POSTN: view

Pathways for POSTN Gene

SuperPathways for POSTN Gene

No Data Available

Interacting Proteins for POSTN Gene

Gene Ontology (GO) - Biological Process for POSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 8363580
GO:0007155 cell adhesion IDA 12235007
GO:0008593 regulation of Notch signaling pathway IEA --
GO:0009888 tissue development IEA --
GO:0030198 extracellular matrix organization IBA --
genes like me logo Genes that share ontologies with POSTN: view

No data available for Pathways by source for POSTN Gene

Compounds for POSTN Gene

(1) HMDB Compounds for POSTN Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(2) Novoseek inferred chemical compound relationships for POSTN Gene

Compound -log(P) Hits PubMed IDs
estrogen 0 1
vegf 0 2
genes like me logo Genes that share compounds with POSTN: view

Transcripts for POSTN Gene

Unigene Clusters for POSTN Gene

Periostin, osteoblast specific factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POSTN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20a · 20b ^
SP1: - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: -
SP7: -
SP8: -
SP9:

ExUns: 21a · 21b ^ 22 ^ 23a · 23b · 23c · 23d
SP1: -
SP2: -
SP3:
SP4: - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:

Relevant External Links for POSTN Gene

GeneLoc Exon Structure for
POSTN
ECgene alternative splicing isoforms for
POSTN

Expression for POSTN Gene

mRNA expression in normal human tissues for POSTN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for POSTN Gene

This gene is overexpressed in Artery - Coronary (4.6), Artery - Aorta (4.4), and Heart - Atrial Appendage (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for POSTN Gene

SOURCE GeneReport for Unigene cluster for POSTN Gene Hs.136348

mRNA Expression by UniProt/SwissProt for POSTN Gene

Q15063-POSTN_HUMAN
Tissue specificity: Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers.
genes like me logo Genes that share expressions with POSTN: view

Orthologs for POSTN Gene

This gene was present in the common ancestor of animals.

Orthologs for POSTN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POSTN 36
  • 99.6 (n)
  • 99.64 (a)
POSTN 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POSTN 36
  • 91.36 (n)
  • 94.99 (a)
POSTN 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POSTN 36
  • 92.88 (n)
  • 96 (a)
POSTN 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Postn 36
  • 85.17 (n)
  • 89.74 (a)
Postn 16
Postn 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POSTN 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POSTN 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Postn 36
  • 85.02 (n)
  • 90.47 (a)
chicken
(Gallus gallus)
Aves OSF-2 37
  • 74 (a)
OneToOne
POSTN 36
  • 74.71 (n)
  • 77.72 (a)
lizard
(Anolis carolinensis)
Reptilia POSTN 37
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia postn 36
  • 69.74 (n)
  • 69.78 (a)
zebrafish
(Danio rerio)
Actinopterygii postna 37
  • 42 (a)
OneToMany
postnb 36
  • 60.67 (n)
  • 59.79 (a)
postnb 37
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43333 37
  • 7 (a)
ManyToMany
Fas1 37
  • 19 (a)
ManyToMany
mfas 37
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F26E4.7 37
  • 19 (a)
OneToMany
Species with no ortholog for POSTN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POSTN Gene

ENSEMBL:
Gene Tree for POSTN (if available)
TreeFam:
Gene Tree for POSTN (if available)

Paralogs for POSTN Gene

Paralogs for POSTN Gene

Selected SIMAP similar genes for POSTN Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with POSTN: view

Variants for POSTN Gene

Sequence variations from dbSNP and Humsavar for POSTN Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs6750 -- 37,562,695(-) AAATT(C/G)AGTAA utr-variant-3-prime
rs12848 -- 37,562,942(-) AAATG(C/G)ACGCA utr-variant-3-prime
rs769131 -- 37,599,498(+) CACTT(A/T)ATGTG upstream-variant-2KB
rs1006415 -- 37,590,326(-) TATTG(G/T)TATTT intron-variant
rs1006416 -- 37,590,308(-) ACTGA(C/T)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POSTN Gene

Variant ID Type Subtype PubMed ID
esv34109 CNV Loss 18971310
nsv832583 CNV Loss 17160897
nsv818956 CNV Gain 17921354

Relevant External Links for POSTN Gene

HapMap Linkage Disequilibrium report
POSTN
Human Gene Mutation Database (HGMD)
POSTN

Disorders for POSTN Gene

(1) MalaCards Diseases for POSTN Gene

Search for POSTN Gene in MalaCards »

(17) Novoseek inferred disease relationships for POSTN Gene

Disease -log(P) Hits PubMed IDs
metastasis 35.2 24
cancer 31.6 34
pancreatic cancer 29.6 13
tumors 29.4 50
hnscc 23.9 4

Relevant External Links for POSTN

Genetic Association Database (GAD)
POSTN
Human Genome Epidemiology (HuGE) Navigator
POSTN
genes like me logo Genes that share disorders with POSTN: view

No data available for UniProtKB/Swiss-Prot for POSTN Gene

Publications for POSTN Gene

  1. Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. (PMID: 8363580) Takeshita S. … Amann E. (Biochem. J. 1993) 2 3 4 23
  2. Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility. (PMID: 12235007) Gillan L. … Chang D.D. (Cancer Res. 2002) 2 3 4 23
  3. Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. (PMID: 15082792) Shao R. … Wang X.-F. (Mol. Cell. Biol. 2004) 3 4 23
  4. Serum level of the periostin, a homologue of an insect cell adhesion molecule, as a prognostic marker in nonsmall cell lung carcinomas. (PMID: 11550156) Sasaki H. … Chen L.B. (Cancer 2001) 3 4 23
  5. Polymorphisms in the KDR and POSTN genes: association with breast cancer susceptibility and prognosis. (PMID: 16807673) FAPrsti A. … Hemminki K. (Breast Cancer Res. Treat. 2007) 3 23 49

Products for POSTN Gene

Sources for POSTN Gene

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