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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

POSTN Gene

protein-coding GIFtS: 57
GCID: GC13M038136

periostin, osteoblast specific factor

Explore 57 diseases affiliated with
POSTN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Periostin, Osteoblast Specific Factor¹ ²		RP11-412K4.1²
PN¹ ² ³ ⁵		Osteoblast Specific Factor 2 (Fasciclin I-Like)²
OSF-2¹ ² ³		Periodontal Ligament-Specific Periostin²
OSF2² ³ ⁵		Periostin Isoform Thy2²
Periostin¹		Periostin Isoform Thy4²
Osteoblast-Specific Factor 2² ³		Periostin Isoform Thy6²
PDLPOSTN²		Periostin Isoform Thy8²

External Ids:	HGNC: 16953¹	Entrez Gene: 10631²	Ensembl: ENSG00000133110⁷	OMIM: 608777⁵	UniProtKB: Q15063³

Export aliases for POSTN gene to outside databases

Previous GC identifers: GC13M035934 GC13M037034 GC13M018936

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: POSTN_HUMAN, Q15063

Function: Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic

activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell

adhesion. May play a role in extracellular matrix mineralization

Gene Wiki entry for POSTN (Periostin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the POSTN gene promoter:
LHX3b/Lhx3b GATA-3 Nkx2-2 Lmo2 Evi-1 SRY E2F-1 E2F HOXA5 LHX3a/Lhx3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: POSTN promoter sequence

Search SABiosciences Chromatin IP Primers for POSTN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POSTN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.3 Ensembl cytogenetic band: 13q13.3 HGNC cytogenetic band: 13q13.3

POSTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POSTN gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M038136: view genomic region (about GC identifiers)

Start:	38,136,719 bp from pter	End:	38,172,981 bp from pter
Size:	36,263 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: POSTN_HUMAN, Q15063 (See protein sequence)

Recommended Name: Periostin precursor

Size: 836 amino acids; 93314 Da

Subunit: Interacts with BMP1 and fibronectin (By similarity)

Subcellular location: Golgi apparatus (By similarity). Secreted, extracellular space, extracellular matrix.

Note=Co-localizes with BMP1 in the Golgi (By similarity)

Secondary accessions: Q15064 Q29XZ0 Q3KPJ5 Q5VSY5 Q8IZF9

Alternative splicing: 4 isoforms: Q15063-1 Q15063-2 Q15063-3 Q15063-4

Explore the universe of human proteins at neXtProt for POSTN: NX_Q15063

Post-translational modifications:

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the

binding of calcium¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q15063

POSTN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001129406.1 NP_001129407.1 NP_001129408.1 NP_006466.2

ENSEMBL proteins:

ENSP00000369073 ENSP00000369071 ENSP00000369067 ENSP00000369066 ENSP00000437959

ENSP00000437953

Human Recombinant Protein Products for POSTN:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for POSTN (Periostin/OSF-2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: POSTN OriGene Protein Over-expression Lysate: POSTN OriGene Custom Protein Services for POSTN
	GenScript Custom Purified and Recombinant Proteins Services for POSTN
	Novus Biologicals POSTN Lysate
	Sino Biological Recombinant Protein for POSTN
	ProSpec Recombinant Protein for POSTN
	Uscn Proteins for POSTN

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	ISS	--
GO:0005794	Golgi apparatus	IEA	--
GO:0031012	colocalizes with extracellular matrix	IDA	--

POSTN for ontologies About GeneDecksing

POSTN Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of POSTN
	R&D Systems Antibodies for POSTN (Periostin/OSF-2)
	OriGene Antibodies: POSTN OriGene Custom Antibody Services for POSTN
	GenScript Custom Superior Antibodies Services for POSTN
	Novus Biologicals POSTN Antibodies
	Abcam antibodies for POSTN
	Uscn Antibodies for POSTN
	Search ThermoFisher Antibodies for POSTN

Assay Products for POSTN:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for POSTN (Periostin/OSF-2) (see all)
	GenScript Custom Assay Services for POSTN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for POSTN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

POSTN for domains About GeneDecksing

3 InterPro domains/families:

IPR011489 EMI_domain

IPR016666 TGFb-ind_bIGH3/osteoblast_fac2

IPR000782 FAS1_domain

Graphical View of Domain Structure for InterPro Entry Q15063

ProtoNet protein and cluster: Q15063

2 Blocks protein families:

IPB000782 Beta-Ig-H3/Fasciclin domain

IPB011489 EMI

UniProtKB/Swiss-Prot: POSTN_HUMAN, Q15063

Similarity: Contains 1 EMI domain

Similarity: Contains 4 FAS1 domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: POSTN_HUMAN, Q15063

Function: Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic

activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell

adhesion. May play a role in extracellular matrix mineralization

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008201	heparin binding	ISS	--

POSTN for ontologies About GeneDecksing

Phenotypes:
13 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Postn):

cardiovascular system	cellular	craniofacial	endocrine/exocrine gland	growth/size
homeostasis/metabolism	immune system	limbs/digits/tail	mortality/aging	muscle
reproductive system	skeleton	tumorigenesis

POSTN for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for POSTN: Postn^tm1Kudo Postn^tm1Jmol

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for POSTN

miRNA Products:		OriGene 3'-UTR Clone (see all 4): POSTN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POSTN
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate POSTN (see all 9):
		hsa-miR-142-5p hsa-miR-183* hsa-miR-19b hsa-miR-202 hsa-miR-561 hsa-miR-32* hsa-miR-340 hsa-miR-19a

		SwitchGear 3'UTR luciferase reporter plasmid: POSTN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POSTN (see all 7) OriGene shRNA RFP: POSTN OriGene siRNA: POSTN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POSTN
		Sirion Biotech Custom design and validation of potent shRNA sequences against POSTN

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for POSTN
			Sirion Biotech Customized adenovirus for overexpression of POSTN Sirion Biotech Customized adenovirus for potent knockdown of POSTN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POSTN (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POSTN (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): POSTN (NM_006475)
		Sino Biological Human cDNA Clone for POSTN
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for POSTN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POSTN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for POSTN
		LifeMap BioReagents: cell lines associated with POSTN: PureStem 4D20.8, NCr-fac Progenitor, PureStem 7SMOO32, NCr-fac & Meso Progenitor, PureStem E15, Meso-prx/latp Progenitor, PureStem ES-210, Ecto-ntu Progenitor, PureStem MEL2, NCr-fac Progenitor
		Sirion Biotech Customized stable knockdown cell line services for POSTN Sirion Biotech Customized inducible knockdown cell line services for POSTN Sirion Biotech Customized stable overexpressing cell line services for POSTN Sirion Biotech Customized inducible overexpressing cell line services for POSTN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POSTN

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for POSTN

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for POSTN (Q15063^{2, 3} ENSP00000369071⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRAPPC2L	Q9UL33²^,³, ENSP00000301021⁴	MINT-8201496 I2D: score=1 STRING: ENSP00000301021
TLE1	ENSP00000365682⁴	STRING: ENSP00000365682
--	Q9CQP2²	MINT-8201482

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	TAS	8363580
GO:0007155	cell adhesion	IDA	12235007
GO:0008593	regulation of Notch signaling pathway	IEA	--
GO:0009888	tissue development	IEA	--
GO:0030198	extracellular matrix organization	IEA	--

POSTN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

POSTN for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for POSTN

1 HMDB Compound for POSTN About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

2 Novoseek chemical compound relationships for POSTN gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
estrogen	0	1	17014703 (1)
vegf	0	3	19412434 (1), 16979964 (1)

Search CenterWatch for drugs/clinical trials and news about POSTN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for POSTN gene (4 alternative transcripts):

NM_001135934.1 NM_001135935.1 NM_001135936.1 NM_006475.2

Unigene Clusters for POSTN:

Periostin, osteoblast specific factor

Hs.136348 [show with all ESTs], Hs.721018 [show with all ESTs]

Unigene Representative Sequences: NM_006475, AK021444

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000379749 ENST00000379747(uc010tet.2 uc001uwo.4 uc001uwp.4 uc010teu.1 uc010tev.1)

ENST00000379743 ENST00000379742 ENST00000478947 ENST00000473823 ENST00000474646

ENST00000497145 ENST00000541179(uc001uwr.3 uc001uwq.3 uc010tew.1)

ENST00000541481(uc010tex.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): POSTN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POSTN
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate POSTN (see all 9):
		hsa-miR-142-5p hsa-miR-183* hsa-miR-19b hsa-miR-202 hsa-miR-561 hsa-miR-32* hsa-miR-340 hsa-miR-19a

		SwitchGear 3'UTR luciferase reporter plasmid: POSTN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POSTN (see all 7) OriGene shRNA RFP: POSTN OriGene siRNA: POSTN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POSTN
		Sirion Biotech Custom design and validation of potent shRNA sequences against POSTN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POSTN (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POSTN (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): POSTN (NM_006475)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for POSTN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POSTN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POSTN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat POSTN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POSTN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POSTN

Additional cDNA sequence: AK021444.1

20 DOTS entries:

DT.455851 DT.92455521 DT.95130883 DT.100786679 DT.40290028 DT.95074198 DT.95311906 DT.438562

DT.95218519 DT.95218517 DT.102842890 DT.120768687 DT.120768695 DT.65285802 DT.100786683 DT.440146

DT.95137786 DT.99934594 DT.120768694 DT.422386

24/395 AceView cDNA sequences (see all 395):

AU280468 CA414075 AI570915 BI711202 AU139611 W80698 AI352132 BM876259

BM091517 BP343708 AI624178 AU117696 BU628321 AI754619 CA445843 AI754260

AU117842 CA391797 AW192631 AI097468 BU071382 AW085816 AI985893 CA447855

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for POSTN (see all 9) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18a	·	18b	·	18c	^	19a	·	19b	·	19c	^	20a	·	20b	^
SP1:																																					-						-						-
SP2:																																			-		-		-		-		-						-
SP3:																																			-		-						-						-
SP4:																																			-		-		-		-		-						-
SP5:																																			-		-		-		-		-		-		-		-

ExUns:	21a	·	21b	^	22	^	23a	·	23b	·	23c	·	23d
SP1:			-
SP2:			-
SP3:
SP4:	-		-
SP5:	-		-

ECgene alternative splicing isoforms for POSTN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

POSTN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAAGCTAAG

About this image

POSTN expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/12 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 12)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Caudal Endochondral Bones

Endochondral Preosteoblasts

Selective marker (cell-identifying gene)

Bone

Endochondral Facial Bones

Endochondral Preosteoblasts

Bone

Membranous Facial Bones

Intramembranous Preosteoblasts

Bone

Rostral Endochondral Facial Bones

Endochondral Preosteoblasts

Bone

Rostral Skull Membranous Bones

Intramembranous Preosteoblasts

Bone

Epicardium

Mature Cardiac Fibroblasts

Epicardium

Extraembryonic Mesoderm

Extraembryonic Capillary Plexus

Extraembryonic Angioblasts

Endothelium

Eye

Inner Nuclear Layer

Type1 Off Cone Bipolar Cells

Bipolar, Retina

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/22 LifeMap Cells (see all 22)

Name

Category

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

Midbrain dopaminergic-like neurons (Generation of midbra...)

Trophoblast-like cells (Generation of tropho...)

See POSTN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POSTN

SOURCE GeneReport for Unigene clusters: Hs.136348 Hs.721018

UniProtKB/Swiss-Prot: POSTN_HUMAN, Q15063

Tissue specificity: Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta,

uterus and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed

at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers

SABiosciences Expression via Pathway-Focused PCR Arrays including POSTN:

Extracellular Matrix & Adhesion Molecules in human mouse rat

Cardiotoxicity in human mouse rat

Allergy & Asthma in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POSTN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat POSTN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POSTN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POSTN

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POSTN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for POSTN gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	POSTN¹	periostin, osteoblast specific factor	75.02(n) 78.32(a)		395429 NM_001030541.1 NP_001025712.1
lizard (Anolis carolinensis)	Reptilia	POSTN⁶	--	74(a)	1 ↔ 1	2(82311774-82394800)
tropical clawed frog (Xenopus tropicalis)	Amphibia	CF345375.1²	--	80.73(n)		CF345375.1
zebrafish (Danio rerio)	Actinopterygii	postnb¹	periostin, osteoblast specific factor b	60.5(n) 58.98(a)		337176 NM_203421.1 NP_981966.1
fruit fly (Drosophila melanogaster)	Insecta	mfas¹	midline fasciclin	39.31(n) 24.69(a)		41455 NM_176477.1 NP_788654.1

ENSEMBL Gene Tree for POSTN (if available)
TreeFam Gene Tree for POSTN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for POSTN gene

TGFBI²

1 SIMAP similar gene for POSTN using alignment to 4 protein entries: POSTN_HUMAN (see all proteins):

TGFBI

POSTN for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5802883^1,2	C	--	38136282(+)	`GATTC-/TTTTTT`	4	--	ds500¹		2		NA CSA	4
rs141074595^1,2		--	38136469(+)	`AGAGAC/TGGGTT`	4	--	ds500¹		0	--	--	--	--
rs9576302^1,2	C,F,A,H	--	38136579(+)	`CGGCCG/ATCTAA`	4	--	ds500¹		26		NS EA NA CSA WA	2770
rs190221279^1,2		--	38136656(+)	`TGCACA/GTCCTG`	4	--	ds500¹		0	--	--	--	--
rs182479207^1,2		--	38136666(+)	`GCACAC/TGCCTG`	4	--	ds500¹		0	--	--	--	--
rs9547951^1,2	C,F,A,H	--	38136682(+)	`CCCTGC/AGCTTA`	4	--	ds500¹		17		NS EA WA NA CSA	779
rs57400150^1,2	C,F	--	38136706(+)	`GAAAAA/GCTCAA`	4	--	ds500¹		6		WA CSA NA EA	364
rs6750^1,2	C,F,A,H	--	38136832(-)	`AAATTG/CAGTAA`	4	--	ut3¹ ese³		12		MN NA NS EA	936
rs114411640^1,2	F	--	38136974(+)	`AGTAAA/GCCCAC`	4	--	ut3¹		1		WA	118
rs185228257^1,2		--	38137061(+)	`CATGGA/GGAGAT`	4	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for POSTN (38136719 - 38172981 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for POSTN
2 CNVs: 9709 47992

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POSTN

DNA2.0 Custom Variant and Variant Library Synthesis for POSTN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

POSTN for disorders           About GeneDecksing

OMIM gene information: 608777    OMIM disorders: --

20/57 diseases for POSTN (see all 57):    About MalaCards

periodontitis malignant pleural mesothelioma bile duct carcinoma idiopathic interstitial pneumonia

myocardial infarction connective tissue disease melorheostosis acute myocardial infarction

corneal dystrophy esophageal squamous cell carcinoma fibrous dysplasia squamous cell carcinoma

peyronie's disease peyronies disease breast cancer susceptibility pancreatic ductal adenocarcinoma

bronchial asthma papillary thyroid carcinoma epithelial ovarian cancer periostitis

10/17 Novoseek disease relationships for POSTN gene (see all 17) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	35.2	39	17060937 (4), 15880581 (4), 19212687 (3), 18086302 (2) (see all 14)
cancer	31.6	42	17616943 (5), 17408641 (4), 18381746 (3), 18086302 (2) (see all 22)
pancreatic cancer	29.6	19	18381746 (6), 17043657 (6), 20106105 (1)
tumors	29.4	79	18086302 (7), 18434370 (4), 15082792 (3), 11509119 (3) (see all 28)
hnscc	23.9	8	16849536 (4)
nsclc	19.7	13	18949745 (4), 11509119 (3), 11550156 (2)
scar	16.1	24	18560459 (3), 17649947 (3)
calcification	15.8	1	16093362 (1)
cancer lung	14.3	7	19328625 (4), 19533256 (2), 11509119 (1)
breast cancer	13.6	15	19524268 (4), 17938160 (3), 15082792 (3), 16807673 (2) (see all 6)

Human Genome Epidemiology (HuGE) Navigator: POSTN (9 documents)

Export disorders for POSTN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for POSTN gene, integrated from 9 sources (see all 188):
(articles sorted by number of sources associating them with POSTN)

Utopia: connect your pdf to the dynamic
world of online information

Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility. (PubMed id 12235007)^{1, 2, 3, 9} Gillan L....Chang D.D. (2002)
Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. (PubMed id 8363580)^{1, 2, 3, 9} Takeshita S.... Amann E. (1993)
Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells. (PubMed id 18450759)^{1, 2, 9} Coutu D.L....Galipeau J. (2008)
Serum level of the periostin, a homologue of an insect cell adhesion molecule, as a prognostic marker in nonsmall cell lung carcinomas. (PubMed id 11550156)^{1, 2, 9} Sasaki H.... Chen L.B. (2001)
Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. (PubMed id 15082792)^{1, 2, 9} Shao R.... Wang X.-F. (2004)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (2004)
Human periostin gene expression in normal tissues, tumors and melanoma: evidences for periostin production by both stromal and melanoma cells. (PubMed id 18086302)^{1, 9} Tilman G....Decottignies A. (2007)
Suppression of cell invasiveness by periostin via TAB 1/TAK1. (PubMed id 19578758)^{1, 9} Isono T....Inoue H. (2009)
Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells. (PubMed id 18381746)^{1, 9} Kanno A....Shimosegawa T. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10631	HGNC: 16953	AceView: POSTN	Ensembl:ENSG00000133110	euGenes: HUgn10631
ECgene: POSTN	H-InvDB: POSTN

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for POSTN	Pharmacogenomics, SNPs, Pathways

Intellectual Property for POSTN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for POSTN gene:
Search GeneIP for patents involving POSTN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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Recombinant Protein for POSTN

POSTN Proteins, Antibodies, CLIAs, and ELISAs

Cell Lines associated with POSTN: PureStem 4D20.8, NCr-fac Progenitor,
PureStem 7SMOO32, NCr-fac & Meso Progenitor, PureStem E15, Meso-prx/latp Progenitor, PureStem ES-210, Ecto-ntu Progenitor,
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POSTN

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POSTN

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for POSTN

Sirion Biotech Customized:

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periostin, osteoblast specific factor

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periostin, osteoblast specific factor

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