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POR Gene(Protein Coding)

Cytochrome P450 Oxidoreductase

GCID:
GC07P075899
GIFtS:
72
Genes Participants
UDN Logo

Aliases for POR Gene

Aliases for POR Gene

  • Cytochrome P450 Oxidoreductase 2 3
  • P450 (Cytochrome) Oxidoreductase 2 3 5
  • EC 1.6.2.4 4 63
  • CYPOR 3 4
  • P450R 3 4
  • CPR 3 4
  • NADPH-Dependent Cytochrome P450 Reductase 3

External Ids for POR Gene

Previous GeneCards Identifiers for POR Gene

  • GC07P074118
  • GC07P075181
  • GC07P075195
  • GC07P075156
  • GC07P075189
  • GC07P075227
  • GC07P075382
  • GC07P075528
  • GC07P070631

Summaries for POR Gene

Entrez Gene Summary for POR Gene

  • This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for POR Gene

POR (Cytochrome P450 Oxidoreductase) is a Protein Coding gene. Diseases associated with POR include Disordered Steroidogenesis Due To Cytochrome P450 Oxidoreductase and Antley-Bixler Syndrome With Genital Anomalies And Disordered Steroidogenesis. Among its related pathways are cytochrome P450 and Phase II conjugation. GO annotations related to this gene include enzyme binding and hydrolase activity.

UniProtKB/Swiss-Prot for POR Gene

  • This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

Gene Wiki entry for POR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POR Gene

Genomics for POR Gene

Products:

  1. Regulatory Element

Regulatory Elements for POR Gene

Enhancers for POR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POR on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the POR gene promoter:

Genomic Location for POR Gene

Chromosome:
7
Start:
75,899,200 bp from pter
End:
75,986,855 bp from pter
Size:
87,656 bases
Orientation:
Plus strand

Genomic View for POR Gene

Genes around POR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POR Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for POR Gene

Proteins for POR Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for POR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16435-NCPR_HUMAN
    Recommended name:
    NADPH--cytochrome P450 reductase
    Protein Accession:
    P16435
    Secondary Accessions:
    • Q16455
    • Q197M5
    • Q8N181
    • Q9H3M8
    • Q9UDT3

    Protein attributes for POR Gene

    Size:
    677 amino acids
    Molecular mass:
    76690 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Cofactor:
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH34277.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for POR Gene

neXtProt entry for POR Gene

Proteomics data for POR Gene at MOPED

Protein Expression for POR Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for POR Gene

P16435:

Post-translational modifications for POR Gene

  • Ubiquitination at Lys 56 and Lys 487
  • Modification sites at PhosphoSitePlus

Other Protein References for POR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for POR (POR/Cytochrome P450 Reductase)

Domains & Families for POR Gene

Protein Domains for POR Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for POR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16435

UniProtKB/Swiss-Prot:

NCPR_HUMAN :
  • Contains 1 FAD-binding FR-type domain.
  • Belongs to the NADPH--cytochrome P450 reductase family.
Domain:
  • Contains 1 FAD-binding FR-type domain.
  • Contains 1 flavodoxin-like domain.
Family:
  • Belongs to the NADPH--cytochrome P450 reductase family.
  • In the N-terminal section; belongs to the flavodoxin family.
  • In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
genes like me logo Genes that share domains with POR: view

No data available for Gene Families for POR Gene

Function for POR Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for POR Gene

GENATLAS Biochemistry:
P-450 (cytochrome) oxidoreductase
UniProtKB/Swiss-Prot CatalyticActivity:
NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.
UniProtKB/Swiss-Prot Function:
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

Enzyme Numbers (IUBMB) for POR Gene

Gene Ontology (GO) - Molecular Function for POR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21081644
GO:0008941 nitric oxide dioxygenase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with POR: view

Phenotypes for POR Gene

MGI mutant phenotypes for POR:
inferred from 6 alleles
GenomeRNAi human phenotypes for POR:
genes like me logo Genes that share phenotypes with POR: view

Human Phenotype Ontology for POR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for POR Gene

MGI Knock Outs for POR:

Animal Model Products

miRNA for POR Gene

miRTarBase miRNAs that target POR

Inhibitory RNA Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for POR Gene

Localization for POR Gene

Subcellular locations from UniProtKB/Swiss-Prot for POR Gene

Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POR Gene COMPARTMENTS Subcellular localization image for POR gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 3
mitochondrion 3
nucleus 3
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for POR Gene

Pathways & Interactions for POR Gene

genes like me logo Genes that share pathways with POR: view

Gene Ontology (GO) - Biological Process for POR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003420 regulation of growth plate cartilage chondrocyte proliferation IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0009437 carnitine metabolic process IEA --
GO:0009812 flavonoid metabolic process IEA --
GO:0019395 fatty acid oxidation IEA --
genes like me logo Genes that share ontologies with POR: view

No data available for SIGNOR curated interactions for POR Gene

Drugs & Compounds for POR Gene

Products:

  1. Drug

(72) Drugs for POR Gene - From: DrugBank, PharmGKB, ApexBio, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Benzphetamine Approved, Illicit Pharma Enzyme, substrate 0
Daunorubicin Approved Pharma Enzyme, substrate 254
Mitomycin Approved Pharma Enzyme, substrate Inhibits DNA synthesis,antibiotic and antitumor agent 0
Ethylmorphine Approved, Illicit Pharma Enzyme 0
FAD Approved Pharma Target 0

(78) Additional Compounds for POR Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
 53-57-6
(R)-lipoic acid
  • (+)-alpha-Lipoic acid
  • (R)-(+)-lipoic acid
  • (R)-1,2-Dithiolane-3-pentanoic acid
  • (R)-1,2-dithiolane-3-valeric acid
  • (R)-6,8-thioctic acid
 1200-22-2
(S)-lipoic acid
  • (S)-(−)-lipoic acid
  • (S)-1,2-dithiolane-3-pentanoic acid
  • (S)-alpha-lipoic acid
  • L-1,2-dithiolane 3-valeric acid
  • L-6,8-thioctic acid
 1077-27-6
Ferrocytochrome
  • 553-12-8 (FREE ACID)
  • Ferrocytochrome b-561
  • H2ppIX
  • HEM
  • Kammerer'S porphyrin
 1818-68-4
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
 53-59-8

(4) ApexBio Compounds for POR Gene

Compound Action Cas Number
Abiraterone acetate Cytochrome p450 17a1 inhibitor 154229-18-2
Avasimibe ACAT inhibitor,orally bioavailable 166518-60-1
Ifosfamide Cytostatic agent 3778-73-2
Ketoconazole Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase 65277-42-1
genes like me logo Genes that share compounds with POR: view

Transcripts for POR Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for POR Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(498) Selected AceView cDNA sequences:
(24) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POR Gene

P450 (cytochrome) oxidoreductase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POR Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - -
SP6:
SP7: - - -
SP8: - -
SP9:
SP10:
SP11: - - -
SP12: - -
SP13: - -
SP14:
SP15: - - -
SP16: - - - -

ExUns: 15c ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for POR Gene

GeneLoc Exon Structure for
POR
ECgene alternative splicing isoforms for
POR

Expression for POR Gene

Products:

  1. Primer

mRNA expression in normal human tissues for POR Gene

mRNA expression in normal human tissues for POR Gene
mRNA expression by BioGPS for POR GenemRNA expression by GTEx for POR Gene

mRNA differential expression in normal tissues according to GTEx for POR Gene

This gene is overexpressed in Liver (x7.9), Whole Blood (x4.7), and Adrenal Gland (x4.2).

Protein differential expression in normal tissues from HIPED for POR Gene

This gene is overexpressed in Liver (13.4), Adrenal (8.2), and Placenta (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POR Gene



SOURCE GeneReport for Unigene cluster for POR Gene Hs.354056

genes like me logo Genes that share expression patterns with POR: view

Protein tissue co-expression partners for POR Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for POR Gene

Orthologs for POR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia POR 35
  • 89.79 (n)
  • 92.49 (a)
POR 36
  • 92 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia POR 35
  • 90.45 (n)
  • 93.5 (a)
OR 36
  • 90 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Por 35
  • 86.41 (n)
  • 92.17 (a)
Por 16
Por 36
  • 92 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia POR 35
  • 99.17 (n)
  • 99.71 (a)
POR 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Por 35
  • 86.85 (n)
  • 92.61 (a)
oppossum
(Monodelphis domestica)
 Mammalia POR 36
  • 88 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 36
  • 4 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves POR 35
  • 78.86 (n)
  • 82.96 (a)
POR 36
  • 83 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia POR 36
  • 81 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia por 35
  • 72.09 (n)
  • 80.33 (a)
African clawed frog
(Xenopus laevis)
 Amphibia MGC69029 35
zebrafish
(Danio rerio)
 Actinopterygii -- 35
por 35
  • 70.89 (n)
  • 72.98 (a)
por 36
  • 72 (a)
 OneToMany
POR (2 of 2) 36
  • 75 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta Cpr 37
  • 58 (a)
Cpr 35
  • 63.12 (n)
  • 57.49 (a)
Cpr 36
  • 57 (a)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea K10D2.6 37
  • 50 (a)
emb-8 35
  • 51.83 (n)
  • 49.61 (a)
emb-8 36
  • 48 (a)
 OneToOne
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AAL121C 35
  • 49.97 (n)
  • 39.21 (a)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0D08712g 35
  • 47.1 (n)
  • 38.7 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes NCP1 35
  • 48.57 (n)
  • 36.94 (a)
NCP1 36
  • 31 (a)
 OneToMany
thale cress
(Arabidopsis thaliana)
 eudicotyledons ATR2 35
  • 48.23 (n)
  • 40.55 (a)
soybean
(Glycine max)
 eudicotyledons Gma.9633 35
barley
(Hordeum vulgare)
 Liliopsida Hv.1549 35
rice
(Oryza sativa)
 Liliopsida Os.27682 35
Os09g0558900 35
  • 49.37 (n)
  • 41.98 (a)
wheat
(Triticum aestivum)
 Liliopsida Ta.2785 35
bread mold
(Neurospora crassa)
 Ascomycetes NCU09741 35
  • 54.69 (n)
  • 41.43 (a)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes ccr1 35
  • 46.77 (n)
  • 41.12 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.1215 36
  • 51 (a)
 OneToOne
Species with no ortholog for POR:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for POR Gene

ENSEMBL:
Gene Tree for POR (if available)
TreeFam:
Gene Tree for POR (if available)

Paralogs for POR Gene

(3) SIMAP similar genes for POR Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with POR: view

No data available for Paralogs for POR Gene

Variants for POR Gene

Sequence variations from dbSNP and Humsavar for POR Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1057868 - 75,985,688(+) GCCTG(C/T)CGGGG reference, missense
VAR_004618 -
VAR_021154 Disordered steroidogenesis due to cytochrome P450 oxidoreductase deficiency (DISPORD)
VAR_021155 Antley-Bixler syndrome, with genital anomalies and disordered steroidogenesis (ABS1)
VAR_021155 Disordered steroidogenesis due to cytochrome P450 oxidoreductase deficiency (DISPORD)

Structural Variations from Database of Genomic Variants (DGV) for POR Gene

Variant ID Type Subtype PubMed ID
nsv528969 CNV Gain 19592680
essv14753 CNV CNV 17122850
dgv120n16 CNV Deletion 17901297
dgv2103e1 CNV Complex 17122850
nsv428173 CNV Gain 18775914
dgv2104e1 CNV Complex 17122850
esv2674423 CNV Deletion 23128226
nsv824168 CNV Gain 20364138

Variation tolerance for POR Gene

Residual Variation Intolerance Score: 78.3% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POR Gene

Human Gene Mutation Database (HGMD)
POR
The Human Cytochrome P450 Allele Nomenclature Database
POR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POR Gene

Disorders for POR Gene

MalaCards: The human disease database

(10) MalaCards diseases for POR Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
disordered steroidogenesis due to cytochrome p450 oxidoreductase
  • cytochrome p450 oxidoreductase deficiency
antley-bixler syndrome with genital anomalies and disordered steroidogenesis
  • cytochrome p450 oxidoreductase deficiency
bartter syndrome, type 1
  • antley-bixler syndrome with genital anomalies and disordered steroidogenesis
cytochrome p450 oxidoreductase deficiency
  • antley-bixler syndrome
antley-bixler syndrome
  • trapezoidocephaly-synostosis syndrome
- elite association - COSMIC cancer census association via MalaCards
Search POR in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NCPR_HUMAN
  • Antley-Bixler syndrome, with genital anomalies and disordered steroidogenesis (ABS1) [MIM:201750]: A disease characterized by the association of Antley-Bixler syndrome with steroidogenesis defects and abnormal genitalia. Antley-Bixler syndrome is characterized by craniosynostosis, radiohumeral synostosis present from the perinatal period, midface hypoplasia, choanal stenosis or atresia, femoral bowing and multiple joint contractures. {ECO:0000269 PubMed:14758361, ECO:0000269 PubMed:15264278, ECO:0000269 PubMed:15483095}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Disordered steroidogenesis due to cytochrome P450 oxidoreductase deficiency (DISPORD) [MIM:613571]: A disorder resulting in a rare variant of congenital adrenal hyperplasia, with apparent combined P450C17 and P450C21 deficiency and accumulation of steroid metabolites. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome. {ECO:0000269 PubMed:14758361, ECO:0000269 PubMed:15220035}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for POR

Genetic Association Database (GAD)
POR
Human Genome Epidemiology (HuGE) Navigator
POR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POR
genes like me logo Genes that share disorders with POR: view

No data available for Genatlas for POR Gene

Publications for POR Gene

  1. Pharmacogenetics of P450 oxidoreductase: effect of sequence variants on activities of CYP1A2 and CYP2C19. (PMID: 18551037) Agrawal V. … Miller W.L. (Pharmacogenet. Genomics 2008) 3 23 48 67
  2. Role of NADPH-cytochrome P450 reductase and cytochrome-b5/NADH-b5 reductase in variability of CYP3A activity in human liver microsomes. (PMID: 18838505) Gan L. … Court M.H. (Drug Metab. Dispos. 2009) 23 25 26
  3. Comparison of in vitro bioactivation of flutamide and its cyano analogue: evidence for reductive activation by human NADPH:cytochrome P450 reductase. (PMID: 19548358) Wen B. … Nelson S.D. (Chem. Res. Toxicol. 2008) 23 25 26
  4. Decrease in NADPH-cytochrome P450 reductase activity of the human heart, Liver and lungs in the presence of alpha-lipoic acid. (PMID: 16391466) Dudka J. (Ann. Nutr. Metab. 2006) 23 25 26
  5. Generation of free radicals during the reductive metabolism of nilutamide by lung microsomes: possible role in the development of lung lesions in patients treated with this anti-androgen. (PMID: 1311586) Berger V. … Pessayre D. (Biochem. Pharmacol. 1992) 23 25 26

Products for POR Gene

Sources for POR Gene

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