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Aliases for POPDC3 Gene

Aliases for POPDC3 Gene

  • Popeye Domain Containing 3 2 3 5
  • Popeye Protein 3 3 4
  • POP3 3 4
  • Popeye Domain-Containing Protein 3 3
  • BA355M14.1 3

External Ids for POPDC3 Gene

Previous GeneCards Identifiers for POPDC3 Gene

  • GC06M105605
  • GC06M105651
  • GC06M105712
  • GC06M103048

Summaries for POPDC3 Gene

Entrez Gene Summary for POPDC3 Gene

  • This gene encodes a member of the POP family of proteins containing three putative transmembrane domains. This gene is expressed in cardiac and skeletal muscle and may play an important role in these tissues during development. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2008]

GeneCards Summary for POPDC3 Gene

POPDC3 (Popeye Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is POPDC2.

UniProtKB/Swiss-Prot for POPDC3 Gene

  • May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding.

Gene Wiki entry for POPDC3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POPDC3 Gene

Genomics for POPDC3 Gene

Regulatory Elements for POPDC3 Gene

Enhancers for POPDC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G105160 1.4 FANTOM5 ENCODE dbSUPER 19.1 +14.4 14449 10.3 PKNOX1 SIN3A ZBTB40 ZNF766 FOS ZEB2 ZNF592 ZNF589 MAFF SMARCA4 BVES POPDC3 PREP GC06M105161
GH06G105135 0.9 Ensembl ENCODE 23.6 +44.7 44729 0.5 CTCF CEBPG RAD21 SCRT2 CUX1 PRDM1 SP7 TRIM28 ZBTB20 POPDC3 PREP BVES-AS1 GC06P105082
GH06G105177 1.4 Ensembl ENCODE dbSUPER 14.3 +0.8 848 3.7 ZSCAN4 ZNF76 ZBTB40 GLIS2 SCRT2 FOS IKZF2 JUNB REST ZEB2 POPDC3 BVES GC06M105161
GH06G105176 0.9 ENCODE dbSUPER 18 +3.4 3391 0.7 ATF1 NFYA NRF1 ZNF384 REST POLR2H FOXM1 POLR2A NFYB ZNF350 BVES POPDC3 GC06M105161
GH06G105209 1.3 Ensembl ENCODE dbSUPER 11.2 -30.5 -30537 2.2 PKNOX1 FEZF1 RAD21 GATA2 FOS CEBPB OVOL3 ZNF843 MEF2D PRDM6 POPDC3 ENSG00000231628 GC06M105240
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POPDC3 on UCSC Golden Path with GeneCards custom track

Promoters for POPDC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000200412 209 1600 ZNF76 GLIS2 IKZF2 JUNB REST ZEB2 ZNF398 ZNF341 IKZF1 MXD3

Genomic Location for POPDC3 Gene

105,157,900 bp from pter
105,180,009 bp from pter
22,110 bases
Minus strand

Genomic View for POPDC3 Gene

Genes around POPDC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POPDC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POPDC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POPDC3 Gene

Proteins for POPDC3 Gene

  • Protein details for POPDC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Popeye domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • B2RA98
    • Q5T3Y8
    • Q8TBW6

    Protein attributes for POPDC3 Gene

    291 amino acids
    Molecular mass:
    33870 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POPDC3 Gene

Post-translational modifications for POPDC3 Gene

  • Glycosylation at posLast=44
  • Modification sites at PhosphoSitePlus

Other Protein References for POPDC3 Gene

No data available for DME Specific Peptides for POPDC3 Gene

Domains & Families for POPDC3 Gene

Protein Domains for POPDC3 Gene

Suggested Antigen Peptide Sequences for POPDC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the popeye family.
  • Belongs to the popeye family.
genes like me logo Genes that share domains with POPDC3: view

No data available for Gene Families for POPDC3 Gene

Function for POPDC3 Gene

Molecular function for POPDC3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding.

Gene Ontology (GO) - Molecular Function for POPDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0030552 cAMP binding ISS --
genes like me logo Genes that share ontologies with POPDC3: view
genes like me logo Genes that share phenotypes with POPDC3: view

Animal Models for POPDC3 Gene

MGI Knock Outs for POPDC3:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for POPDC3 Gene

Localization for POPDC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POPDC3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POPDC3 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for POPDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 10882522
genes like me logo Genes that share ontologies with POPDC3: view

Pathways & Interactions for POPDC3 Gene

SuperPathways for POPDC3 Gene

No Data Available

Interacting Proteins for POPDC3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000254765 Q9HBV1-POPD3_HUMAN for POPDC3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for POPDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0042391 regulation of membrane potential ISS,IEA --
genes like me logo Genes that share ontologies with POPDC3: view

No data available for Pathways by source and SIGNOR curated interactions for POPDC3 Gene

Drugs & Compounds for POPDC3 Gene

No Compound Related Data Available

Transcripts for POPDC3 Gene

Unigene Clusters for POPDC3 Gene

Popeye domain containing 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POPDC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - - -
SP2: - - - - - -
SP3: - - - - -
SP5: - - -
SP7: - - - -

Relevant External Links for POPDC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POPDC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POPDC3 Gene

mRNA differential expression in normal tissues according to GTEx for POPDC3 Gene

This gene is overexpressed in Muscle - Skeletal (x19.8) and Heart - Left Ventricle (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of POPDC3 Gene:


SOURCE GeneReport for Unigene cluster for POPDC3 Gene:


mRNA Expression by UniProt/SwissProt for POPDC3 Gene:

Tissue specificity: Expressed predominantly in skeletal muscle and detected in heart.

Evidence on tissue expression from TISSUES for POPDC3 Gene

  • Muscle(4.5)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with POPDC3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for POPDC3 Gene

Orthologs for POPDC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for POPDC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia POPDC3 34 35
  • 99.77 (n)
(Canis familiaris)
Mammalia POPDC3 34 35
  • 93.01 (n)
(Bos Taurus)
Mammalia POPDC3 34 35
  • 91.41 (n)
(Mus musculus)
Mammalia Popdc3 34 16 35
  • 87.51 (n)
(Rattus norvegicus)
Mammalia Popdc3 34
  • 85.15 (n)
(Monodelphis domestica)
Mammalia POPDC3 35
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia POPDC3 35
  • 75 (a)
(Gallus gallus)
Aves POPDC3 34 35
  • 76.09 (n)
(Anolis carolinensis)
Reptilia POPDC3 35
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia popdc3 34
  • 71.32 (n)
Str.19727 34
(Danio rerio)
Actinopterygii popdc3 34 35
  • 64.77 (n)
fruit fly
(Drosophila melanogaster)
Insecta bves 35
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
Species where no ortholog for POPDC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POPDC3 Gene

Gene Tree for POPDC3 (if available)
Gene Tree for POPDC3 (if available)

Paralogs for POPDC3 Gene

Paralogs for POPDC3 Gene

(2) SIMAP similar genes for POPDC3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with POPDC3: view

Variants for POPDC3 Gene

Sequence variations from dbSNP and Humsavar for POPDC3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000021743 -- 105,169,712(+) CCTCA(A/T)ATGCT intron-variant, nc-transcript-variant
rs1000131759 -- 105,176,633(+) CTCAC(G/T)GCAAG intron-variant, upstream-variant-2KB
rs1000166529 -- 105,179,447(+) TTTAT(G/T)TCGGC intron-variant
rs1000231969 -- 105,176,327(+) TGGCT(A/G)CAGCT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000294336 -- 105,169,607(+) GAGAA(A/C)CTCAA intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for POPDC3 Gene

Variant ID Type Subtype PubMed ID
esv2665928 CNV deletion 23128226
esv2759461 CNV gain 17122850
esv3540257 CNV deletion 23714750
esv3610253 CNV loss 21293372
nsv604437 CNV loss 21841781

Variation tolerance for POPDC3 Gene

Residual Variation Intolerance Score: 48.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POPDC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POPDC3 Gene

Disorders for POPDC3 Gene

Relevant External Links for POPDC3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for POPDC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POPDC3 Gene

Publications for POPDC3 Gene

  1. Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart. (PMID: 10882522) Andree B. … Brand T. (Dev. Biol. 2000) 2 3 4 22 64
  2. Genome-wide association study of severity in multiple sclerosis. (PMID: 21654844) (Genes Immun. 2011) 3 46 64
  3. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche. (PMID: 19448622) Sulem P. … Stefansson K. (Nat. Genet. 2009) 3 46 64

Products for POPDC3 Gene

Sources for POPDC3 Gene

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