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Aliases for POPDC2 Gene

Aliases for POPDC2 Gene

  • Popeye Domain Containing 2 2 3 5
  • Popeye Protein 2 3 4
  • POP2 3 4

External Ids for POPDC2 Gene

Previous GeneCards Identifiers for POPDC2 Gene

  • GC03M120643
  • GC03M120681
  • GC03M120843
  • GC03M119355
  • GC03M116736

Summaries for POPDC2 Gene

Entrez Gene Summary for POPDC2 Gene

  • This gene encodes a member of the POP family of proteins which contain three putative transmembrane domains. This membrane associated protein is predominantly expressed in skeletal and cardiac muscle, and may have an important function in these tissues. [provided by RefSeq, Jul 2008]

GeneCards Summary for POPDC2 Gene

POPDC2 (Popeye Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include cAMP binding. An important paralog of this gene is POPDC3.

UniProtKB/Swiss-Prot for POPDC2 Gene

  • May play an important role in heart development.

Gene Wiki entry for POPDC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POPDC2 Gene

Genomics for POPDC2 Gene

Regulatory Elements for POPDC2 Gene

Enhancers for POPDC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POPDC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for POPDC2 Gene

119,636,457 bp from pter
119,665,324 bp from pter
28,868 bases
Minus strand

Genomic View for POPDC2 Gene

Genes around POPDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POPDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POPDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POPDC2 Gene

Proteins for POPDC2 Gene

  • Protein details for POPDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Popeye domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q86UE7

    Protein attributes for POPDC2 Gene

    364 amino acids
    Molecular mass:
    40448 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH26911.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for POPDC2 Gene


neXtProt entry for POPDC2 Gene

Proteomics data for POPDC2 Gene at MOPED

Post-translational modifications for POPDC2 Gene

  • Glycosylation at Asn 4
  • Modification sites at PhosphoSitePlus

Other Protein References for POPDC2 Gene

Antibody Products

No data available for DME Specific Peptides for POPDC2 Gene

Domains & Families for POPDC2 Gene

Protein Domains for POPDC2 Gene


Suggested Antigen Peptide Sequences for POPDC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the popeye family.
  • Belongs to the popeye family.
genes like me logo Genes that share domains with POPDC2: view

No data available for Gene Families for POPDC2 Gene

Function for POPDC2 Gene

Molecular function for POPDC2 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in heart development.
genes like me logo Genes that share phenotypes with POPDC2: view

Animal Models for POPDC2 Gene

MGI Knock Outs for POPDC2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POPDC2 Gene

Localization for POPDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POPDC2 Gene

Membrane; Multi-pass membrane protein. Cell membrane, sarcolemma.

Subcellular locations from

Jensen Localization Image for POPDC2 Gene COMPARTMENTS Subcellular localization image for POPDC2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for POPDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane NAS 10882522
genes like me logo Genes that share ontologies with POPDC2: view

Pathways & Interactions for POPDC2 Gene

SuperPathways for POPDC2 Gene

No Data Available

Interacting Proteins for POPDC2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9HBU9-POPD2_HUMAN ENSP00000264231 for POPDC2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for POPDC2 Gene


No data available for Pathways by source and SIGNOR curated interactions for POPDC2 Gene

Drugs & Compounds for POPDC2 Gene

No Compound Related Data Available

Transcripts for POPDC2 Gene

Unigene Clusters for POPDC2 Gene

Popeye domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POPDC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: - -

Relevant External Links for POPDC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POPDC2 Gene

mRNA expression in normal human tissues for POPDC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for POPDC2 Gene

This gene is overexpressed in Heart - Left Ventricle (x20.7), Heart - Atrial Appendage (x11.9), and Colon - Sigmoid (x4.3).

Protein differential expression in normal tissues from HIPED for POPDC2 Gene

This gene is overexpressed in Fetal heart (47.5), Urinary Bladder (8.0), and Heart (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POPDC2 Gene

SOURCE GeneReport for Unigene cluster for POPDC2 Gene Hs.656031

mRNA Expression by UniProt/SwissProt for POPDC2 Gene

Tissue specificity: Expressed predominantly in the heart and in the skeletal muscle.
genes like me logo Genes that share expression patterns with POPDC2: view

Protein tissue co-expression partners for POPDC2 Gene

- Elite partner

Primer Products

Orthologs for POPDC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for POPDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia POPDC2 35
  • 84.96 (n)
  • 82.18 (a)
  • 78 (a)
(Mus musculus)
Mammalia Popdc2 35
  • 81.51 (n)
  • 79.89 (a)
Popdc2 16
Popdc2 36
  • 75 (a)
(Pan troglodytes)
Mammalia POPDC2 35
  • 99.27 (n)
  • 99.73 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Popdc2 35
  • 81.7 (n)
  • 80.46 (a)
(Canis familiaris)
Mammalia POPDC2 36
  • 80 (a)
(Monodelphis domestica)
Mammalia POPDC2 36
  • 71 (a)
(Gallus gallus)
Aves POPDC2 35
  • 70.13 (n)
  • 65.75 (a)
  • 59 (a)
(Anolis carolinensis)
Reptilia POPDC2 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia popdc2 35
  • 65.21 (n)
  • 61.87 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10593 35
(Danio rerio)
Actinopterygii popdc2 35
  • 59.16 (n)
  • 58.2 (a)
popdc2 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta bves 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
Species with no ortholog for POPDC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POPDC2 Gene

Gene Tree for POPDC2 (if available)
Gene Tree for POPDC2 (if available)

Paralogs for POPDC2 Gene

Paralogs for POPDC2 Gene

(2) SIMAP similar genes for POPDC2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with POPDC2: view

Variants for POPDC2 Gene

Sequence variations from dbSNP and Humsavar for POPDC2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs4688023 - 119,660,339(+) GTAGA(C/T)AGCCC nc-transcript-variant, reference, missense
rs1728 -- 119,642,215(+) CTTGC(C/T)CAAGA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs8007 -- 119,642,403(+) GAGGC(A/G)TGCCT nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs8422 -- 119,642,097(+) TGCCA(C/G/T)GGCAT nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1872432 -- 119,656,355(-) ATAAT(C/T)CGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POPDC2 Gene

Variant ID Type Subtype PubMed ID
nsv829695 CNV Loss 17160897
nsv527724 CNV Loss 19592680
nsv520805 CNV Loss 19592680

Variation tolerance for POPDC2 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.41; 85.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for POPDC2 Gene

Disorders for POPDC2 Gene

Relevant External Links for POPDC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for POPDC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POPDC2 Gene

Publications for POPDC2 Gene

  1. Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart. (PMID: 10882522) Andree B. … Brand T. (Dev. Biol. 2000) 2 3 4 23 67
  2. POPDC1S201F causes muscular dystrophy and arrhythmia by affecting protein trafficking. (PMID: 26642364) Schindler R.F. … Ferlini A. (J. Clin. Invest. 2016) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Mutants of GABA transaminase (POP2) suppress the severe phenotype of succinic semialdehyde dehydrogenase (ssadh) mutants in Arabidopsis. (PMID: 18846220) Ludewig F. … BouchAc N. (PLoS ONE 2008) 23
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for POPDC2 Gene

Sources for POPDC2 Gene