POP7 Gene
protein-coding GIFtS: 50
GCID: GC07P100303
|
|
processing of precursor 7, ribonuclease P/MRP subunit (S....(Previous names: processing of precursor 7, ribonuclease P subunit (S. cerevisiae)...)
| |
Aliases
for POP7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Processing Of Precursor 7, Ribonuclease P/MRP Subunit (S. Cerevisiae)1 2 | | Processing Of Precursor 7, Ribonuclease P Subunit (S. Cerevisiae)1 | | RPP201 2 3 5 | | 0610037N12Rik2 | | RPP21 2 | | POP7 (Processing Of Precursor, S. Cerevisiae) Homolog2 | | Ribonucleases P/MRP Protein Subunit POP7 Homolog2 3 | | Processing Of Precursor 7, Ribonuclease P Subunit2 | | HPOP71 | | Ribonuclease P Protein Subunit P202 | | RNaseP Protein P202 3 | | EC 3.1.26.53 |
Export aliases for POP7 gene to outside databasesPrevious GC identifers: GC07P099917 GC07P099948 GC07P100141 GC07P094934 |
Summaries
for POP7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: POP7_HUMAN, O75817Function: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends
Gene Wiki entry for POP7
|
Genomic Views
for POP7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the POP7 gene promoter:
ER-alpha AP-1 ATF-2 p300 MyoD Lmo2 CREB deltaCREB c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for POP7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POP7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22POP7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P100303: view genomic region
(about GC identifiers)
Start:
|
100,303,676 bp from pter |
End:
|
100,305,123 bp from pter |
Size:
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1,448 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 99,663,281-99,664,728 |
|
Proteins
for POP7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: POP7_HUMAN, O75817 (See
protein sequence)Recommended Name: Ribonuclease P protein subunit p20 Size: 140 amino acids; 15651 Da
Subunit: Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a RNA moiety and at least 8protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of a RNAmoiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 andRPP21. Interacts with RPP25. RPP20/POP7 is probably a dimer
Subcellular location: Nucleus, nucleolus (Potential)
Secondary accessions: A4D2E0 Q9BV74Explore the universe of human proteins at neXtProt for POP7: NX_O75817
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75817
POP7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005828.2
ENSEMBL proteins: ENSP00000304353 ENSP00000387814
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
POP7 for ontologies About GeneDecksing
POP7 Antibody Products:
Assay Products for POP7: |
Protein
Domains /
Families
for POP7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
POP7 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O75817ProtoNet protein and cluster: O75817 1 Blocks protein family: IPB002775 Alba
UniProtKB/Swiss-Prot: POP7_HUMAN, O75817Similarity: Belongs to the histone-like Alba family |
Function
for POP7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: POP7_HUMAN, O75817Function: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-endsCatalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursorEnzyme Number (IUBMB): EC 3.1.26.51
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POP7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POP7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: POP7 (NM_005837) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POP7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POP7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POP7 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
POP7 for ontologies About GeneDecksing
|
Pathways & Interactions
for POP7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ribosome biogenesis in eukaryotes | | | 2 | RNA transport | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for POP7):
POP7 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POP7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/14 Interacting proteins for POP7 (O758171, 3 ENSP000003043534) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008033 | tRNA processing |
IEA | -- |
POP7 for ontologies About GeneDecksing
|
Drugs & Compounds
for POP7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for POP7
Search CenterWatch for drugs/clinical trials and news about POP7
|
Transcripts
for POP7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for POP7 gene: NM_005837.2 Unigene Cluster for POP7: Processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) Hs.416994 [show with all ESTs]Unigene Representative Sequence: BU9448022 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000303151(uc003uwh.4) ENST00000457480
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POP7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POP7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: POP7 (NM_005837) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POP7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POP7 |
Additional cDNA sequence: BC001430.2 U94316.1 5 DOTS entries: DT.455756 DT.92431061 DT.92431059 DT.95286851 DT.102824457 24/168 AceView cDNA sequences (see all 168): CA397459 BE786338 BG114477 AW901739 CK819581 BE382563 AI739502 BX099360 AJ572668 AW296527 BQ188243 AI080645 CR608631 BQ435258 CR608046 BQ068209 BE252325 CR601550 BF797977 AI417351 CA308079 BE294892 BE279294 BC001430
GeneLoc Exon Structure
|
Expression
for POP7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| POP7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAGAAAAGG
About this image
See POP7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POP7
SOURCE GeneReport for Unigene cluster: Hs.416994
SABiosciences Custom PCR Arrays for POP7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POP7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POP7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POP7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POP7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POP7 |
Orthologs
for POP7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for POP7 gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Pop71 , 5 |
processing of precursor 7, ribonuclease P family, (S. more1, 5 |
87.38(n)1
95(a)1 |
|
5 (76.51 cM)5
740971 NM_028753.21 NP_083029.11
1375014385 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufj61g072 |
Transcribed sequence with weak similarity to protein more |
77.88(n) |
|
BM571356.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Rpp206 |
Rpp20 |
31(a) |
1 ↔ 1 |
X(19638464-19639780) |
worm
(Caenorhabditis elegans) |
Secernentea |
Y62E10A.26 |
-- |
32(a) |
1 ↔ 1 |
IV(13370629-13371589) |
ENSEMBL Gene Tree for POP7 (if available)
TreeFam Gene Tree for POP7 (if available) |
Paralogs
for POP7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for POP7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for POP7 (100303676 - 100305123 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for POP7
1 CNV: 4550 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POP7 |
|
Disorders
/ Diseases
for POP7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
POP7 for disorders About GeneDecksing
OMIM gene information: 606113
OMIM disorders: --
1  disease for POP7: About MalaCardscartilage-hair hypoplasia
Export disorders for POP7 gene to outside databases
|
Publications
for POP7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for POP7 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with POP7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P. (PubMed id 9630247)1, 2, 3, 9 Jarrous N.... Altman S. (1998)
- Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. (PubMed id 15096576)1, 2 Welting T.J.... Pruijn G.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Rpp20 interacts with SMN and is re-distributed into SMN granules in response to stress. (PubMed id 14715275)1, 9 Hua Y. and Zhou J. (2004)
- Rpp2, an essential protein subunit of nuclear RNase P, is required for processing of precursor tRNAs and 35S precursor rRNA in Saccharomyces cerevisiae. (PubMed id 9618478)1, 9 Stolc V....Altman S. (1998)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for POP7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing POP7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing POP7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing POP7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for POP7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for POP7 gene:
Search GeneIP for patents involving POP7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for POP7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for POP7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POP7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POP7 | | | OriGene Protein Over-expression Lysate for POP7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for POP7 | | OriGene 3'-UTR Clone for POP7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POP7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POP7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for POP7 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for POP7 | | OriGene Custom Protein Services for POP7 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POP7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POP7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POP7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POP7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POP7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POP7 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for POP7 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | POP7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POP7 |
|  |  |  | | | | Search ThermoFisher Antibodies for POP7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POP7 |
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