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Aliases for POP7 Gene

Aliases for POP7 Gene

  • POP7 Homolog, Ribonuclease P/MRP Subunit 2 3 5
  • Ribonucleases P/MRP Protein Subunit POP7 Homolog 3 4
  • RNaseP Protein P20 3 4
  • RPP20 3 4
  • HPOP7 3 4
  • Processing Of Precursor 7, Ribonuclease P/MRP Subunit (S. Cerevisiae) 2
  • Processing Of Precursor 7, Ribonuclease P Subunit (S. Cerevisiae) 2
  • POP7 (Processing Of Precursor, S. Cerevisiae) Homolog 3
  • Processing Of Precursor 7, Ribonuclease P/MRP Subunit 3
  • Processing Of Precursor 7, Ribonuclease P Subunit 3
  • Ribonuclease P Protein Subunit P20 2
  • 0610037N12Rik 3
  • EC 3.1.26.5 4
  • RPP2 3

External Ids for POP7 Gene

Previous GeneCards Identifiers for POP7 Gene

  • GC07P099917
  • GC07P099948
  • GC07P100141
  • GC07P100303
  • GC07P094934

Summaries for POP7 Gene

GeneCards Summary for POP7 Gene

POP7 (POP7 Homolog, Ribonuclease P/MRP Subunit) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include nucleic acid binding and ribonuclease P activity.

UniProtKB/Swiss-Prot for POP7 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences.

Gene Wiki entry for POP7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POP7 Gene

Genomics for POP7 Gene

Regulatory Elements for POP7 Gene

Promoters for POP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POP7 on UCSC Golden Path with GeneCards custom track

Genomic Location for POP7 Gene

Chromosome:
7
Start:
100,706,053 bp from pter
End:
100,707,500 bp from pter
Size:
1,448 bases
Orientation:
Plus strand

Genomic View for POP7 Gene

Genes around POP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POP7 Gene

Proteins for POP7 Gene

  • Protein details for POP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75817-POP7_HUMAN
    Recommended name:
    Ribonuclease P protein subunit p20
    Protein Accession:
    O75817
    Secondary Accessions:
    • A4D2E0
    • Q9BV74

    Protein attributes for POP7 Gene

    Size:
    140 amino acids
    Molecular mass:
    15651 Da
    Quaternary structure:
    • Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and SMN1. RPP20/POP7 is probably a dimer.

neXtProt entry for POP7 Gene

Proteomics data for POP7 Gene at MOPED

Post-translational modifications for POP7 Gene

  • Ubiquitination at Lys 42 and Lys 46
  • Modification sites at PhosphoSitePlus

Other Protein References for POP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POP7 Gene

Domains & Families for POP7 Gene

Protein Domains for POP7 Gene

Suggested Antigen Peptide Sequences for POP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75817

UniProtKB/Swiss-Prot:

POP7_HUMAN :
  • Belongs to the histone-like Alba family.
Family:
  • Belongs to the histone-like Alba family.
genes like me logo Genes that share domains with POP7: view

No data available for Gene Families for POP7 Gene

Function for POP7 Gene

Molecular function for POP7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor.
UniProtKB/Swiss-Prot Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences.

Enzyme Numbers (IUBMB) for POP7 Gene

genes like me logo Genes that share phenotypes with POP7: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POP7 Gene

Localization for POP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POP7 Gene

Nucleus, nucleolus. Cytoplasm. Cytoplasmic granule. Note=Under stress conditions colocalizes with SMN1 in punctuated cytoplasmic granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POP7 Gene COMPARTMENTS Subcellular localization image for POP7 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for POP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with POP7: view

Pathways & Interactions for POP7 Gene

genes like me logo Genes that share pathways with POP7: view

Pathways by source for POP7 Gene

Gene Ontology (GO) - Biological Process for POP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010467 gene expression TAS --
GO:0090501 RNA phosphodiester bond hydrolysis TAS 9630247
genes like me logo Genes that share ontologies with POP7: view

No data available for SIGNOR curated interactions for POP7 Gene

Drugs & Compounds for POP7 Gene

No Compound Related Data Available

Transcripts for POP7 Gene

mRNA/cDNA for POP7 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(168) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POP7 Gene

Processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POP7 Gene

No ASD Table

Relevant External Links for POP7 Gene

GeneLoc Exon Structure for
POP7
ECgene alternative splicing isoforms for
POP7

Expression for POP7 Gene

mRNA expression in normal human tissues for POP7 Gene

Protein differential expression in normal tissues from HIPED for POP7 Gene

This gene is overexpressed in Lung (35.9), Peripheral blood mononuclear cells (8.3), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POP7 Gene



SOURCE GeneReport for Unigene cluster for POP7 Gene Hs.416994

genes like me logo Genes that share expression patterns with POP7: view

Protein tissue co-expression partners for POP7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POP7 Gene

Orthologs for POP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for POP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POP7 35
  • 99.05 (n)
  • 100 (a)
POP7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POP7 36
  • 97 (a)
OneToOne
POP7 35
  • 89.52 (n)
  • 97.14 (a)
dog
(Canis familiaris)
Mammalia POP7 35
  • 90.24 (n)
  • 98.57 (a)
POP7 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pop7 35
  • 87.38 (n)
  • 95 (a)
Pop7 36
  • 95 (a)
OneToOne
Pop7 16
oppossum
(Monodelphis domestica)
Mammalia POP7 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POP7 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pop7 35
  • 87.62 (n)
  • 96.43 (a)
zebrafish
(Danio rerio)
Actinopterygii pop7 36
  • 66 (a)
OneToOne
pop7 35
  • 68.27 (n)
  • 74.4 (a)
wufj61g07 35
fruit fly
(Drosophila melanogaster)
Insecta Rpp20 36
  • 31 (a)
OneToOne
Rpp20 35
  • 59.68 (n)
  • 49.52 (a)
worm
(Caenorhabditis elegans)
Secernentea Y62E10A.2 36
  • 32 (a)
OneToOne
Species with no ortholog for POP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for POP7 Gene

ENSEMBL:
Gene Tree for POP7 (if available)
TreeFam:
Gene Tree for POP7 (if available)

Paralogs for POP7 Gene

No data available for Paralogs for POP7 Gene

Variants for POP7 Gene

Sequence variations from dbSNP and Humsavar for POP7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1045338 -- 100,706,161(+) GGCGC(C/G)CACGA utr-variant-5-prime
rs1045343 -- 100,706,918(+) GCCGC(C/T)TGCCC reference, synonymous-codon
rs1045366 -- 100,707,180(+) CGACA(C/G)ACGGG reference, missense
rs11559028 -- 100,707,241(+) AGGGT(A/C/G)ACACC reference, synonymous-codon
rs58847330 -- 100,704,175(+) GATCG(C/T)GCCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for POP7 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv888779 CNV Loss 21882294
dgv7399n71 CNV Loss 21882294
nsv831072 CNV Loss 17160897
nsv888791 CNV Loss 21882294
nsv470381 CNV Loss 18288195
nsv8184 CNV Loss 18304495
nsv888792 CNV Loss 21882294

Variation tolerance for POP7 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POP7 Gene

HapMap Linkage Disequilibrium report
POP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POP7 Gene

Disorders for POP7 Gene

Relevant External Links for POP7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POP7

No disorders were found for POP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POP7 Gene

Publications for POP7 Gene

  1. Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P. (PMID: 9630247) Jarrous N. … Altman S. (RNA 1998) 2 3 4 23 67
  2. Rpp20 interacts with SMN and is re-distributed into SMN granules in response to stress. (PMID: 14715275) Hua Y. … Zhou J. (Biochem. Biophys. Res. Commun. 2004) 3 23
  3. Rpp2, an essential protein subunit of nuclear RNase P, is required for processing of precursor tRNAs and 35S precursor rRNA in Saccharomyces cerevisiae. (PMID: 9618478) Stolc V. … Altman S. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for POP7 Gene

Sources for POP7 Gene

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