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Aliases for POP7 Gene

Aliases for POP7 Gene

  • Processing Of Precursor 7, Ribonuclease P/MRP Subunit (S. Cerevisiae) 2 3
  • RPP20 3 4 6
  • Ribonucleases P/MRP Protein Subunit POP7 Homolog 3 4
  • Ribonuclease P Protein Subunit P20 2 3
  • RNaseP Protein P20 3 4
  • HPOP7 3 4
  • Processing Of Precursor 7, Ribonuclease P Subunit (S. Cerevisiae) 2
  • POP7 (Processing Of Precursor, S. Cerevisiae) Homolog 3
  • Processing Of Precursor 7, Ribonuclease P Subunit 3
  • 0610037N12Rik 3
  • EC 3.1.26.5 4
  • RPP2 3

External Ids for POP7 Gene

Previous GeneCards Identifiers for POP7 Gene

  • GC07P099917
  • GC07P099948
  • GC07P100141
  • GC07P100303
  • GC07P094934

Summaries for POP7 Gene

GeneCards Summary for POP7 Gene

POP7 (Processing Of Precursor 7, Ribonuclease P/MRP Subunit (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are RNA transport and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include ribonuclease P activity.

UniProtKB/Swiss-Prot for POP7 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences

Gene Wiki entry for POP7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POP7 Gene

Genomics for POP7 Gene

Regulatory Elements for POP7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for POP7 Gene

Start:
100,706,053 bp from pter
End:
100,707,500 bp from pter
Size:
1,448 bases
Orientation:
Plus strand

Genomic View for POP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POP7 Gene

Proteins for POP7 Gene

  • Protein details for POP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75817-POP7_HUMAN
    Recommended name:
    Ribonuclease P protein subunit p20
    Protein Accession:
    O75817
    Secondary Accessions:
    • A4D2E0
    • Q9BV74

    Protein attributes for POP7 Gene

    Size:
    140 amino acids
    Molecular mass:
    15651 Da
    Quaternary structure:
    • Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and SMN1. RPP20/POP7 is probably a dimer.

neXtProt entry for POP7 Gene

Proteomics data for POP7 Gene at MOPED

Post-translational modifications for POP7 Gene

  • Ubiquitination at Lys42 and Lys46
  • Modification sites at PhosphoSitePlus

Other Protein References for POP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POP7 Gene

Domains for POP7 Gene

Protein Domains for POP7 Gene

Suggested Antigen Peptide Sequences for POP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75817

UniProtKB/Swiss-Prot:

POP7_HUMAN :
  • O75817
Family:
  • Belongs to the histone-like Alba family.
genes like me logo Genes that share domains with POP7: view

No data available for Gene Families for POP7 Gene

Function for POP7 Gene

Molecular function for POP7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor
UniProtKB/Swiss-Prot Function: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences

Enzyme Numbers (IUBMB) for POP7 Gene

Gene Ontology (GO) - Molecular Function for POP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004526 contributes_to ribonuclease P activity IBA --
GO:0005515 protein binding IPI 14715275
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with POP7: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POP7

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for POP7 Gene

Localization for POP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POP7 Gene

Nucleus, nucleolus. Cytoplasm. Cytoplasmic granule. Note=Under stress conditions colocalizes with SMN1 in punctuated cytoplasmic granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POP7 Gene COMPARTMENTS Subcellular localization image for POP7 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for POP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005655 nucleolar ribonuclease P complex TAS 9630247
GO:0005737 cytoplasm --
GO:0030678 mitochondrial ribonuclease P complex IBA --
genes like me logo Genes that share ontologies with POP7: view

Pathways for POP7 Gene

genes like me logo Genes that share pathways with POP7: view

Pathways by source for POP7 Gene

2 KEGG pathways for POP7 Gene

Gene Ontology (GO) - Biological Process for POP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IBA --
GO:0090501 RNA phosphodiester bond hydrolysis --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IBA --
genes like me logo Genes that share ontologies with POP7: view

Transcripts for POP7 Gene

mRNA/cDNA for POP7 Gene

(168) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POP7 Gene

Processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POP7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POP7 Gene

No ASD Table

Relevant External Links for POP7 Gene

GeneLoc Exon Structure for
POP7
ECgene alternative splicing isoforms for
POP7

Expression for POP7 Gene

mRNA expression in normal human tissues for POP7 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POP7 Gene

SOURCE GeneReport for Unigene cluster for POP7 Gene Hs.416994

genes like me logo Genes that share expressions with POP7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POP7 Gene

Orthologs for POP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for POP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POP7 35
  • 99.05 (n)
  • 100 (a)
POP7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POP7 35
  • 89.52 (n)
  • 97.14 (a)
POP7 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POP7 35
  • 90.24 (n)
  • 98.57 (a)
POP7 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pop7 35
  • 87.38 (n)
  • 95 (a)
Pop7 16
Pop7 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POP7 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POP7 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pop7 35
  • 87.62 (n)
  • 96.43 (a)
zebrafish
(Danio rerio)
Actinopterygii pop7 35
  • 68.27 (n)
  • 74.4 (a)
pop7 36
  • 66 (a)
OneToOne
wufj61g07 35
fruit fly
(Drosophila melanogaster)
Insecta Rpp20 35
  • 59.68 (n)
  • 49.52 (a)
Rpp20 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y62E10A.2 36
  • 32 (a)
OneToOne
Species with no ortholog for POP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for POP7 Gene

ENSEMBL:
Gene Tree for POP7 (if available)
TreeFam:
Gene Tree for POP7 (if available)

Paralogs for POP7 Gene

No data available for Paralogs for POP7 Gene

Variants for POP7 Gene

Sequence variations from dbSNP and Humsavar for POP7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs13199 -- 100,707,417(+) TTAGT(G/T)GGCCT utr-variant-3-prime
rs221770 -- 100,704,471(-) CCTCC(A/T)CACAT upstream-variant-2KB
rs221771 -- 100,704,202(-) TCGCT(C/T)CGTTG upstream-variant-2KB
rs968469 -- 100,706,317(-) CGCCC(A/C)TCCCG intron-variant
rs1045338 -- 100,706,161(+) GGCGC(C/G)CACGA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for POP7 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv888779 CNV Loss 21882294
dgv7399n71 CNV Loss 21882294
nsv831072 CNV Loss 17160897
nsv888791 CNV Loss 21882294
nsv470381 CNV Loss 18288195
nsv8184 CNV Loss 18304495
nsv888792 CNV Loss 21882294

Relevant External Links for POP7 Gene

HapMap Linkage Disequilibrium report
POP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POP7 Gene

Disorders for POP7 Gene

No disorders were found for POP7 Gene.

No data available for UniProtKB/Swiss-Prot for POP7 Gene

Publications for POP7 Gene

  1. Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P. (PMID: 9630247) Jarrous N. … Altman S. (RNA 1998) 2 3 4 23
  2. Rpp20 interacts with SMN and is re-distributed into SMN granules in response to stress. (PMID: 14715275) Hua Y. … Zhou J. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  3. Rpp2, an essential protein subunit of nuclear RNase P, is required for processing of precursor tRNAs and 35S precursor rRNA in Saccharomyces cerevisiae. (PMID: 9618478) Stolc V. … Altman S. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 23
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  5. Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. (PMID: 15096576) Welting T.J. … Pruijn G.J. (Nucleic Acids Res. 2004) 3 4

Products for POP7 Gene

Sources for POP7 Gene

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