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Aliases for POP5 Gene

Aliases for POP5 Gene

  • POP5 Homolog, Ribonuclease P/MRP Subunit 2 3 5
  • HPop5 3 4
  • Processing Of Precursor 5, Ribonuclease P/MRP Subunit (S. Cerevisiae) 2
  • Processing Of Precursor 5, Ribonuclease P/MRP Subunit 3
  • EC 3.1.26.5 4
  • HSPC004 3
  • RPP20 3
  • RPP2 3

External Ids for POP5 Gene

Previous GeneCards Identifiers for POP5 Gene

  • GC12M119898
  • GC12M120614
  • GC12M120800
  • GC12M119428
  • GC12M119479
  • GC12M121016
  • GC12M118026

Summaries for POP5 Gene

GeneCards Summary for POP5 Gene

POP5 (POP5 Homolog, Ribonuclease P/MRP Subunit) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include ribonuclease activity and ribonuclease P activity.

UniProtKB/Swiss-Prot for POP5 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP.

Gene Wiki entry for POP5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POP5 Gene

Genomics for POP5 Gene

Regulatory Elements for POP5 Gene

Promoters for POP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POP5 on UCSC Golden Path with GeneCards custom track

Genomic Location for POP5 Gene

Chromosome:
12
Start:
120,578,764 bp from pter
End:
120,581,452 bp from pter
Size:
2,689 bases
Orientation:
Minus strand

Genomic View for POP5 Gene

Genes around POP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POP5 Gene

Proteins for POP5 Gene

  • Protein details for POP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969H6-POP5_HUMAN
    Recommended name:
    Ribonuclease P/MRP protein subunit POP5
    Protein Accession:
    Q969H6
    Secondary Accessions:
    • A6NL80
    • Q53FS5
    • Q9Y2Q6

    Protein attributes for POP5 Gene

    Size:
    163 amino acids
    Molecular mass:
    18820 Da
    Quaternary structure:
    • Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21.
    Miscellaneous:
    • The last C-terminal 19 amino acids are not required for complex association and RNase activity.

    Alternative splice isoforms for POP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POP5 Gene

Proteomics data for POP5 Gene at MOPED

Post-translational modifications for POP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POP5 Gene

Domains & Families for POP5 Gene

Protein Domains for POP5 Gene

Graphical View of Domain Structure for InterPro Entry

Q969H6

UniProtKB/Swiss-Prot:

POP5_HUMAN :
  • Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
Family:
  • Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
genes like me logo Genes that share domains with POP5: view

No data available for Gene Families for POP5 Gene

Function for POP5 Gene

Molecular function for POP5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor.
UniProtKB/Swiss-Prot Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP.

Enzyme Numbers (IUBMB) for POP5 Gene

genes like me logo Genes that share phenotypes with POP5: view

Animal Model Products

miRNA for POP5 Gene

miRTarBase miRNAs that target POP5

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POP5 Gene

Localization for POP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POP5 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POP5 Gene COMPARTMENTS Subcellular localization image for POP5 gene
Compartment Confidence
nucleus 5
extracellular 3
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for POP5 Gene

Pathways & Interactions for POP5 Gene

genes like me logo Genes that share pathways with POP5: view

Pathways by source for POP5 Gene

Gene Ontology (GO) - Biological Process for POP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0010467 gene expression TAS --
GO:0090501 RNA phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with POP5: view

No data available for SIGNOR curated interactions for POP5 Gene

Drugs & Compounds for POP5 Gene

No Compound Related Data Available

Transcripts for POP5 Gene

Unigene Clusters for POP5 Gene

Processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POP5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6: - - -
SP7:
SP8: -

Relevant External Links for POP5 Gene

GeneLoc Exon Structure for
POP5
ECgene alternative splicing isoforms for
POP5

Expression for POP5 Gene

mRNA expression in normal human tissues for POP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POP5 Gene

This gene is overexpressed in Lung (38.3), CD4 Tcells (7.9), Fetal ovary (6.8), and Fetal testis (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POP5 Gene



SOURCE GeneReport for Unigene cluster for POP5 Gene Hs.279913

genes like me logo Genes that share expression patterns with POP5: view

Protein tissue co-expression partners for POP5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POP5 Gene

Orthologs for POP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for POP5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POP5 35
  • 89.16 (n)
  • 91.41 (a)
POP5 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POP5 35
  • 88.34 (n)
  • 92.64 (a)
POP5 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pop5 35
  • 85.36 (n)
  • 93.24 (a)
Pop5 16
Pop5 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POP5 35
  • 99.18 (n)
  • 100 (a)
POP5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pop5 35
  • 86.71 (n)
  • 91.22 (a)
oppossum
(Monodelphis domestica)
Mammalia POP5 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POP5 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves POP5 35
  • 66.17 (n)
  • 64.93 (a)
POP5 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POP5 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pop5 35
  • 64.38 (n)
  • 64.38 (a)
Str.19320 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4975 35
zebrafish
(Danio rerio)
Actinopterygii pop5 35
  • 58.73 (n)
  • 54.42 (a)
wufc69d03 35
pop5 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14057 36
  • 30 (a)
OneToOne
Species with no ortholog for POP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POP5 Gene

ENSEMBL:
Gene Tree for POP5 (if available)
TreeFam:
Gene Tree for POP5 (if available)

Paralogs for POP5 Gene

No data available for Paralogs for POP5 Gene

Variants for POP5 Gene

Sequence variations from dbSNP and Humsavar for POP5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7174 -- 120,579,368(+) CTCTA(A/G)TAAGC reference, synonymous-codon
rs591992 -- 120,581,520(-) TTGAG(A/G)GAGCT upstream-variant-2KB
rs509445 -- 120,579,440(+) ATGAA(A/C)GATAT intron-variant
rs523522 -- 120,582,447(-) ttttt(A/T)aaaat upstream-variant-2KB
rs563920 -- 120,579,636(+) GAAAG(A/G)TCTCG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for POP5 Gene

Variant ID Type Subtype PubMed ID
nsv906 CNV Loss 18451855
nsv907 CNV Insertion 18451855

Variation tolerance for POP5 Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POP5 Gene

HapMap Linkage Disequilibrium report
POP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POP5 Gene

Disorders for POP5 Gene

Relevant External Links for POP5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POP5

No disorders were found for POP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POP5 Gene

Publications for POP5 Gene

  1. hPop5, a protein subunit of the human RNase MRP and RNase P endoribonucleases. (PMID: 11413139) van Eenennaam H. … Pruijn G.J.M. (J. Biol. Chem. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3
  5. Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. (PMID: 22458338) Simonis N. … Twizere J.C. (Retrovirology 2012) 3

Products for POP5 Gene

Sources for POP5 Gene

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