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Aliases for POP5 Gene

Aliases for POP5 Gene

  • POP5 Homolog, Ribonuclease P/MRP Subunit 2 3 5
  • HPop5 3 4
  • Processing Of Precursor 5, Ribonuclease P/MRP Subunit (S. Cerevisiae) 2
  • Processing Of Precursor 5, Ribonuclease P/MRP Subunit 3
  • Ribonuclease P/MRP Protein Subunit POP5 3
  • EC 3.1.26.5 4
  • HSPC004 3
  • RPP20 3
  • RPP2 3

External Ids for POP5 Gene

Previous GeneCards Identifiers for POP5 Gene

  • GC12M119898
  • GC12M120614
  • GC12M120800
  • GC12M119428
  • GC12M119479
  • GC12M121016
  • GC12M118026

Summaries for POP5 Gene

GeneCards Summary for POP5 Gene

POP5 (POP5 Homolog, Ribonuclease P/MRP Subunit) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA transport. GO annotations related to this gene include ribonuclease activity and ribonuclease P activity.

UniProtKB/Swiss-Prot for POP5 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP.

Gene Wiki entry for POP5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POP5 Gene

Genomics for POP5 Gene

Regulatory Elements for POP5 Gene

Enhancers for POP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G120533 1.5 FANTOM5 ENCODE 11.5 +44.2 44160 7.1 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 COQ5 GATC POP5 RPL31P52 TRIAP1 ENSG00000111780 SPPL3 C12orf43 ACADS ENSG00000256569
GH12G120583 1.2 Ensembl ENCODE 0.7 -2.8 -2752 2.0 ARID4B GLIS2 ZNF143 ZNF263 REST ZNF579 GLIS1 MXD3 KDM1A HNF4A COQ5 GATC HNF1A-AS1 MLEC UNC119B C12orf43 ENSG00000256569 ACADS OASL SRSF9
GH12G120580 1.1 ENCODE 0.7 +0.1 59 1.9 HDGF PKNOX1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 COQ5 GATC HNF1A-AS1 MLEC UNC119B C12orf43 ACADS ENSG00000256569 OASL SRSF9
GH12G120549 1.2 Ensembl ENCODE 0.3 +30.9 30941 1.4 PKNOX1 FOXA2 ATF1 ARID4B YBX1 YY1 SLC30A9 SP5 PPARG KAT8 COQ5 GATC COX6A1 RPL29P24 NRAV DYNLL1 SRSF9 RPL31P52 TRIAP1 ENSG00000111780
GH12G120554 0.5 ENCODE 0.3 +26.6 26635 1.1 BCOR HDAC2 ADNP ZBTB17 COQ5 GATC RNF10 RPL29P24 RPL31P52 TRIAP1 ENSG00000111780 GC12P120535 POP5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POP5 on UCSC Golden Path with GeneCards custom track

Promoters for POP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058330 52 1601 HDGF PKNOX1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Genomic Location for POP5 Gene

Chromosome:
12
Start:
120,578,764 bp from pter
End:
120,581,452 bp from pter
Size:
2,689 bases
Orientation:
Minus strand

Genomic View for POP5 Gene

Genes around POP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POP5 Gene

Proteins for POP5 Gene

  • Protein details for POP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969H6-POP5_HUMAN
    Recommended name:
    Ribonuclease P/MRP protein subunit POP5
    Protein Accession:
    Q969H6
    Secondary Accessions:
    • A6NL80
    • Q53FS5
    • Q9Y2Q6

    Protein attributes for POP5 Gene

    Size:
    163 amino acids
    Molecular mass:
    18820 Da
    Quaternary structure:
    • Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21.
    Miscellaneous:
    • The last C-terminal 19 amino acids are not required for complex association and RNase activity.

    Alternative splice isoforms for POP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POP5 Gene

Post-translational modifications for POP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POP5 Gene

No data available for DME Specific Peptides for POP5 Gene

Domains & Families for POP5 Gene

Protein Domains for POP5 Gene

Graphical View of Domain Structure for InterPro Entry

Q969H6

UniProtKB/Swiss-Prot:

POP5_HUMAN :
  • Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
Family:
  • Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
genes like me logo Genes that share domains with POP5: view

No data available for Gene Families for POP5 Gene

Function for POP5 Gene

Molecular function for POP5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor.
UniProtKB/Swiss-Prot Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP.

Enzyme Numbers (IUBMB) for POP5 Gene

Gene Ontology (GO) - Molecular Function for POP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004526 ribonuclease P activity IEA --
GO:0004540 ribonuclease activity IEA --
GO:0005515 protein binding IPI 15096576
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with POP5: view
genes like me logo Genes that share phenotypes with POP5: view

Animal Model Products

CRISPR Products

miRNA for POP5 Gene

miRTarBase miRNAs that target POP5

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POP5 Gene

Localization for POP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POP5 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POP5 gene
Compartment Confidence
nucleus 5
extracellular 3
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for POP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005655 nucleolar ribonuclease P complex IEA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with POP5: view

Pathways & Interactions for POP5 Gene

genes like me logo Genes that share pathways with POP5: view

Pathways by source for POP5 Gene

Gene Ontology (GO) - Biological Process for POP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001682 tRNA 5-leader removal TAS --
GO:0008033 tRNA processing IEA --
GO:0016070 RNA metabolic process IEA --
GO:0090501 RNA phosphodiester bond hydrolysis IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with POP5: view

No data available for SIGNOR curated interactions for POP5 Gene

Drugs & Compounds for POP5 Gene

No Compound Related Data Available

Transcripts for POP5 Gene

Unigene Clusters for POP5 Gene

Processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POP5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6: - - -
SP7:
SP8: -

Relevant External Links for POP5 Gene

GeneLoc Exon Structure for
POP5
ECgene alternative splicing isoforms for
POP5

Expression for POP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POP5 Gene

This gene is overexpressed in Lung (38.3), CD4 Tcells (7.9), Fetal ovary (6.8), and Fetal testis (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POP5 Gene



Protein tissue co-expression partners for POP5 Gene

NURSA nuclear receptor signaling pathways regulating expression of POP5 Gene:

POP5

SOURCE GeneReport for Unigene cluster for POP5 Gene:

Hs.279913

Evidence on tissue expression from TISSUES for POP5 Gene

  • Adrenal gland(4.3)
  • Kidney(4.3)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with POP5: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POP5 Gene

Orthologs for POP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for POP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POP5 34 35
  • 99.18 (n)
cow
(Bos Taurus)
Mammalia POP5 34 35
  • 89.16 (n)
dog
(Canis familiaris)
Mammalia POP5 34 35
  • 88.34 (n)
rat
(Rattus norvegicus)
Mammalia Pop5 34
  • 86.71 (n)
mouse
(Mus musculus)
Mammalia Pop5 34 16 35
  • 85.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia POP5 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POP5 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves POP5 34 35
  • 66.17 (n)
lizard
(Anolis carolinensis)
Reptilia POP5 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pop5 34
  • 64.38 (n)
Str.19320 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.4975 34
zebrafish
(Danio rerio)
Actinopterygii pop5 34 35
  • 58.73 (n)
wufc69d03 34
fruit fly
(Drosophila melanogaster)
Insecta CG14057 35
  • 30 (a)
OneToOne
Species where no ortholog for POP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POP5 Gene

ENSEMBL:
Gene Tree for POP5 (if available)
TreeFam:
Gene Tree for POP5 (if available)

Paralogs for POP5 Gene

No data available for Paralogs for POP5 Gene

Variants for POP5 Gene

Sequence variations from dbSNP and Humsavar for POP5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000106196 -- 120,581,524(+) CTCTC(A/C)AGCCC upstream-variant-2KB
rs1000492739 -- 120,582,506(+) TCTCA(A/G)TGAAT upstream-variant-2KB
rs1001534288 -- 120,581,355(+) TGAAC(C/G)GCACC reference, missense
rs1004872725 -- 120,578,695(+) AGGCC(C/G)ATCAC downstream-variant-500B
rs1005010871 -- 120,578,873(+) GATAC(C/T)GGGCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for POP5 Gene

Variant ID Type Subtype PubMed ID
nsv906 CNV deletion 18451855
nsv907 CNV insertion 18451855

Variation tolerance for POP5 Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POP5 Gene

Disorders for POP5 Gene

Relevant External Links for POP5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POP5

No disorders were found for POP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POP5 Gene

Publications for POP5 Gene

  1. hPop5, a protein subunit of the human RNase MRP and RNase P endoribonucleases. (PMID: 11413139) van Eenennaam H. … Pruijn G.J.M. (J. Biol. Chem. 2001) 2 3 4 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. (PMID: 15096576) Welting T.J. … Pruijn G.J. (Nucleic Acids Res. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 64

Products for POP5 Gene

Sources for POP5 Gene

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