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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POP4 Gene

protein-coding   GIFtS: 54
GCID: GC19P030097

Processing Of Precursor 4, Ribonuclease P/MRP Subunit (S....

  Search for POP4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Processing Of Precursor 4, Ribonuclease P/MRP Subunit (S.
Cerevisiae)1 2
RPP292 3 5
hPOP42 3
EC 3.1.26.53 8
Ribonuclease P Protein Subunit P292

External Ids:    HGNC: 300811   Entrez Gene: 107752   Ensembl: ENSG000001051717   OMIM: 6061145   UniProtKB: O957073   
ORGUL members:         
NONCODE14:n407825      

Export aliases for POP4 gene to outside databases

Previous GC identifers: GC19P030719 GC19P030546 GC19P034773 GC19P034789 GC19P026609


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POP4 Gene:
This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the
endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is
localized to the nucleus and associates directly with the RNA component of these complexes. This protein is
involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. (provided
by RefSeq, Mar 2009)

GeneCards Summary for POP4 Gene: 
POP4 (processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)) is a protein-coding gene, and is affiliated with the lncRNA class. GO annotations related to this gene include ribonuclease P activity and RNA binding.

UniProtKB/Swiss-Prot: RPP29_HUMAN, O95707
Function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their
5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P

Gene Wiki entry for POP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POP4 gene promoter:
         Bach1   HOXA9B   HOXA9   Bach2   Tal-1beta   NF-AT   AREB6   Meis-1a   ITF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for POP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q12   Ensembl cytogenetic band:  19q12   HGNC cytogenetic band: 19q13.11

POP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POP4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P030097:  view genomic region     (about GC identifiers)

Start:
30,094,924 bp from pter      End:
30,108,162 bp from pter
Size:
13,239 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RPP29_HUMAN, O95707 (See protein sequence)
Recommended Name: Ribonuclease P protein subunit p29  
Size: 220 amino acids; 25425 Da
Subunit: Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a RNA moiety and at
least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists
of a RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40,
POP5 and RPP21. Interacts with RPP25 and POP5
Subcellular location: Nucleus, nucleolus
Secondary accessions: Q5XKL7 Q6FHW9 Q9UQQ3

Explore the universe of human proteins at neXtProt for POP4: NX_O95707

Explore proteomics data for POP4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95707

  • 4/5 DME Specific Peptides for POP4 (O95707) (see all 5)
     TGILLQETKH  SERSAKKFKAKG  LKVIPKLNCVFT  QRAEAFVRAFLK 

    POP4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    POP4 Protein Expression
    REFSEQ proteins: NP_006618.1  
    ENSEMBL proteins: 
     ENSP00000465213   ENSP00000468215   ENSP00000468718   ENSP00000221770   ENSP00000465456  
     ENSP00000467990   ENSP00000376104  

    Human Recombinant Protein Products for POP4: 
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    OriGene Protein Over-expression Lysate for POP4
    OriGene Custom MassSpec 
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    GenScript Custom Purified and Recombinant Proteins Services for POP4
    Novus Biologicals POP4 Proteins
    Novus Biologicals POP4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for POP4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000172ribonuclease MRP complex IEA--
    GO:0005655nucleolar ribonuclease P complex IEA--
    GO:0030677ribonuclease P complex ----

    POP4 for ontologies           About GeneDecksing



    POP4 Antibody Products: 
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    Abcam antibodies for POP4
    Cloud-Clone Corp. Antibodies for POP4 
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    LSBio Antibodies in human, mouse, rat for POP4 

    Assay Products for POP4: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for POP4 
    Cloud-Clone Corp. CLIAs for POP4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR016848 RNase_P/MRP_p29-subunit
     IPR023534 Rof/RNase_P-like
     IPR002730 RNase_P/MRP_p29

    Graphical View of Domain Structure for InterPro Entry O95707

    ProtoNet protein and cluster: O95707

    1 Blocks protein domain: IPB002730 Protein of unknown function UPF0086

    UniProtKB/Swiss-Prot: RPP29_HUMAN, O95707
    Similarity: Belongs to the eukaryotic/archaeal RNase P protein component 1 family


    POP4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPP29_HUMAN, O95707
    Function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their
    5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P
    Catalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor

         Enzyme Number (IUBMB): EC 3.1.26.51 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0004526ribonuclease P activity IEA--
    GO:0004540ribonuclease activity ----
    GO:0005515protein binding IPI15096576
         
    POP4 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pop4):
     mortality/aging 

    POP4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for POP4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POP4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POP4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POP4 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POP4
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate POP4 (see all 16):
    hsa-miR-4303 hsa-miR-4291 hsa-miR-875-3p hsa-miR-548p hsa-miR-1263 hsa-miR-516b hsa-miR-15a hsa-miR-497
    SwitchGear 3'UTR luciferase reporter plasmidPOP4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for POP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POP4

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of POP4

    Clone
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    GenScript: all cDNA clones in your preferred vector: POP4 (NM_006627)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POP4
    Sirion Biotech Customized lentivirus for stable overexpression of POP4 
                         Customized lentivirus expression plasmids for stable overexpression of POP4 

    Cell Line
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    Search LifeMap BioReagents cell lines for POP4
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POP4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for POP4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes
    2RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2         Kegg Pathways  (Kegg details for POP4):
        Ribosome biogenesis in eukaryotes
    RNA transport


    POP4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/12 Interacting proteins for POP4 (O957071, 3 ENSP000002217704) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPP25Q9BUL91, 3, ENSP000003176914EBI-366477,EBI-366570 I2D: score=4 STRING: ENSP00000317691
    POP5Q969H61, 3, ENSP000003500984EBI-366477,EBI-366525 I2D: score=5 STRING: ENSP00000350098
    RPP38P783451, 3, ENSP000003674394EBI-366477,EBI-366493 I2D: score=5 STRING: ENSP00000367439
    POP1Q995751, 3, ENSP000003395294EBI-366477,EBI-366741 I2D: score=5 STRING: ENSP00000339529
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--
    GO:0006379mRNA cleavage IEA--
    GO:0008033tRNA processing IEA--

    POP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POP4 (RPP29)

    Search CenterWatch for drugs/clinical trials and news about POP4 / RPP29

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POP4 gene: 
    NM_006627.2  

    Unigene Cluster for POP4:

    Processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
    Hs.412870  [show with all ESTs]
    Unigene Representative Sequence: NM_006627
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585603 ENST00000586173 ENST00000586420 ENST00000591061 ENST00000221770(uc002nsf.2 uc002nsg.2)
    ENST00000586823 ENST00000591824 ENST00000588551 ENST00000590688 ENST00000586136
    ENST00000592759 ENST00000592749 ENST00000587232 ENST00000392279
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POP4
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate POP4 (see all 16):
    hsa-miR-4303 hsa-miR-4291 hsa-miR-875-3p hsa-miR-548p hsa-miR-1263 hsa-miR-516b hsa-miR-15a hsa-miR-497
    SwitchGear 3'UTR luciferase reporter plasmidPOP4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for POP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POP4
    Clone
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    OriGene clones in human, mouse for POP4 (see all 8)
    OriGene ORF clones in mouse, rat for POP4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POP4 (NM_006627)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POP4
    Sirion Biotech Customized lentivirus for stable overexpression of POP4 
                         Customized lentivirus expression plasmids for stable overexpression of POP4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for POP4
    OriGene qSTAR qPCR primer pairs in human, mouse for POP4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POP4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POP4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POP4

    Additional mRNA sequence: 

    AF001176.2 AK090872.1 AK314790.1 BC004438.1 BC006098.1 BC013686.1 CR536569.1 CR936714.1 
    NR_027368.1 Y18863.1 

    12 DOTS entries:

    DT.219248  DT.92021320  DT.311374  DT.75172550  DT.121489407  DT.92435932  DT.99933112  DT.121489402 
    DT.95197196  DT.121489345  DT.92392293  DT.95197195 

    24/277 AceView cDNA sequences (see all 277):

    NM_006627 CB115592 BG942761 CB141662 BE746054 AA905131 AI346640 CF131080 
    CA314143 CB163102 CD673378 BF434997 CR620341 BM756281 AA251614 AA480963 
    CB141661 CN482672 BE263449 AA934656 BX446078 BE514692 AA134866 BE743749 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for POP4 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e · 10f
    SP1:              -           -     -     -     -     -                 -                 -     -                                                   
    SP2:                          -     -                 -                 -                                                                           
    SP3:              -           -     -     -     -     -           -     -     -           -     -                                                   
    SP4:              -           -     -     -     -     -                 -                 -     -                                                   
    SP5:                                                  -                 -                 -     -                                                   


    ECgene alternative splicing isoforms for POP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCTGAGT
    POP4 Expression
    About this image


    See POP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POP4

    SOURCE GeneReport for Unigene cluster: Hs.412870
        SABiosciences Custom PCR Arrays for POP4
    Primer
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POP4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POP4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for POP4 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pop41 , 5 processing of precursor 4, ribonuclease P/MRP family, more1, 5 83.03(n)1
    83.18(a)1
      7 (25.36 cM)5
    661611  NM_025390.41  NP_079666.11 
     382628205 
    chicken
    (Gallus gallus)
    Aves POP41 processing of precursor 4, ribonuclease P/MRP subunit more 70.61(n)
    69.09(a)
      768362  NM_001145914.1  NP_001139386.1 
    lizard
    (Anolis carolinensis)
    Reptilia POP46
    Uncharacterized protein
    68(a)
    1 ↔ 1
    GL343874.1(201182-201322)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.30402 Xenopus laevis transcribed sequence with weak similarity more 73.85(n)    CA789008.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.62892 Transcribed sequence with weak similarity to protein more 72.94(n)    57059031 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG80381 CG8038 47.24(n)
    39.07(a)
      38889  NM_139911.2  NP_648168.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C15C6.46
    Protein C15C6.4
    24(a)
    1 ↔ 1
    I(12213109-12215184)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes POP4(YBR257W)4 Subunit of both RNase MRP and nuclear RNase P; RNase more   --   2(728885-729724) 852560  NP_009816.1 


    ENSEMBL Gene Tree for POP4 (if available)
    TreeFam Gene Tree for POP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/375 SNPs in POP4 are shown (see all 375)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs116720191,2
    C,F,H--30095182(+) gagatG/Cacacc 2 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1438919791,2
    C--30095239(+) AAAAA-/TATTTT 2 -- us2k10--------
    rs563152731,2
    C--30095241(+) AAATAC/TTTTAA 2 -- us2k10--------
    rs1425281381,2
    --30095312(+) AATTCA/GAGGGG 2 -- us2k10--------
    rs1817004461,2
    --30095343(+) ATCCCA/CGAAGG 2 -- us2k10--------
    rs1460042091,2
    --30095553(+) TGGTGA/GCTATA 2 -- us2k10--------
    rs116690681,2
    C,F,A,H--30095816(+) GTTTAA/CATGTG 2 -- us2k128Minor allele frequency- C:0.18NS EA NA WA 3244
    rs3708000611,2
    C--30095816(+) GTTTA-/A/CATGTG 2 -- us2k10--------
    rs1867124991,2
    --30095853(+) ATAAAC/TGCATA 2 -- us2k10--------
    rs169630851,2
    C,F,H--30095911(+) TGCACG/TCGGGG 2 -- us2k1 tfbs316Minor allele frequency- T:0.09NA NS EA WA 2078

    HapMap Linkage Disequilibrium report for POP4 (30094924 - 30108162 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for POP4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833799CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    POP4 for disorders           About MalaCards
    OMIM gene information: 606114    OMIM disorders: --


    POP4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): POP4

    Export disorders for POP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POP4 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with POP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rpp14 and Rpp29, two protein subunits of human ribonuclease P. (PubMed id 10024167)1, 2, 3, 9 Jarrous N.... Altman S. (1999)
    2. hPop4: a new protein subunit of the human RNase MRP and RNase P ribonucleoprotein complexes. (PubMed id 10352175)1, 2, 3, 9 van Eenennaam H.... van Venrooij W.J. (1999)
    3. Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. (PubMed id 15096576)1, 2 Welting T.J.... Pruijn G.J. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Inhibition of the expression of the human RNase P protein subunits Rpp21, Rpp25, Rpp29 by external guide sequences (EGSs) and siRNA. (PubMed id 15351636)1, 9 Zhang H. and Altman S. (2004)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)
    10. Differential association of protein subunits with the human RNase MRP and RNase P complexes. (PubMed id 16723659)1 Welting T.J....Pruijn G.J. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10775 HGNC: 30081 AceView: POP4 Ensembl:ENSG00000105171 euGenes: HUgn10775
    ECgene: POP4 Kegg: 10775 H-InvDB: POP4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for POP4 gene:
    Search GeneIP for patents involving POP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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