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Aliases for POP4 Gene

Aliases for POP4 Gene

  • Processing Of Precursor 4, Ribonuclease P/MRP Subunit (S. Cerevisiae) 2 3
  • EC 3.1.26.5 4 64
  • RPP29 3 4
  • HPOP4 3 4
  • Ribonuclease P Protein Subunit P29 3
  • RPP29, 6

External Ids for POP4 Gene

Summaries for POP4 Gene

Entrez Gene Summary for POP4 Gene

  • This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

GeneCards Summary for POP4 Gene

POP4 (Processing Of Precursor 4, Ribonuclease P/MRP Subunit (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are RNA transport and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include RNA binding and ribonuclease P activity.

UniProtKB/Swiss-Prot for POP4 Gene

  • Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P

Gene Wiki entry for POP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POP4 Gene

Genomics for POP4 Gene

Genomic Location for POP4 Gene

Start:
29,604,017 bp from pter
End:
29,617,255 bp from pter
Size:
13,239 bases
Orientation:
Plus strand

Genomic View for POP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POP4 Gene

Regulatory Elements for POP4 Gene

Proteins for POP4 Gene

  • Protein details for POP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95707-RPP29_HUMAN
    Recommended name:
    Ribonuclease P protein subunit p29
    Protein Accession:
    O95707
    Secondary Accessions:
    • Q5XKL7
    • Q6FHW9
    • Q9UQQ3

    Protein attributes for POP4 Gene

    Size:
    220 amino acids
    Molecular mass:
    25425 Da
    Quaternary structure:
    • Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and POP5.

neXtProt entry for POP4 Gene

Proteomics data for POP4 Gene at MOPED

Selected DME Specific Peptides for POP4 Gene

Post-translational modifications for POP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POP4 Gene

Domains for POP4 Gene

Protein Domains for POP4 Gene

UniProtKB/Swiss-Prot:

RPP29_HUMAN
Family:
  • Belongs to the eukaryotic/archaeal RNase P protein component 1 family.:
    • O95707
genes like me logo Genes that share domains with POP4: view

No data available for Gene Families for POP4 Gene

Function for POP4 Gene

Molecular function for POP4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor
UniProtKB/Swiss-Prot Function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P

Enzyme Numbers (IUBMB) for POP4 Gene

Gene Ontology (GO) - Molecular Function for POP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000171 contributes_to ribonuclease MRP activity IBA --
GO:0003723 RNA binding TAS 10352175
GO:0004526 contributes_to ribonuclease P activity IBA --
GO:0004540 ribonuclease activity --
GO:0005515 protein binding IPI 15096576
genes like me logo Genes that share ontologies with POP4: view

Phenotypes for POP4 Gene

MGI mutant phenotypes for POP4:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with POP4: view

miRNA for POP4 Gene

miRTarBase miRNAs that target POP4

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for POP4 Gene

Localization for POP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POP4 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POP4 Gene COMPARTMENTS Subcellular localization image for POP4 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for POP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000172 ribonuclease MRP complex IBA --
GO:0005655 nucleolar ribonuclease P complex IEA --
GO:0030677 ribonuclease P complex IBA --
genes like me logo Genes that share ontologies with POP4: view

Pathways for POP4 Gene

genes like me logo Genes that share pathways with POP4: view

Pathways by source for POP4 Gene

2 KEGG pathways for POP4 Gene

Gene Ontology (GO) - Biological Process for POP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IBA --
GO:0006379 mRNA cleavage IEA --
GO:0008033 tRNA processing IEA --
GO:0090501 RNA phosphodiester bond hydrolysis TAS 10352175
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic TAS 10352175
genes like me logo Genes that share ontologies with POP4: view

Transcripts for POP4 Gene

Unigene Clusters for POP4 Gene

Processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POP4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e · 10f
SP1: - - - - - - - - -
SP2: - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - -
SP6: - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - -
SP10:
SP11: -
SP12: - - - - -

Relevant External Links for POP4 Gene

GeneLoc Exon Structure for
POP4
ECgene alternative splicing isoforms for
POP4

Expression for POP4 Gene

mRNA expression in normal human tissues for POP4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POP4 Gene

SOURCE GeneReport for Unigene cluster for POP4 Gene Hs.412870

genes like me logo Genes that share expressions with POP4: view

Orthologs for POP4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POP4 36
  • 99.55 (n)
  • 99.55 (a)
POP4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POP4 36
  • 88.18 (n)
  • 90 (a)
POP4 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POP4 36
  • 87.29 (n)
  • 87.91 (a)
POP4 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pop4 36
  • 82.58 (n)
  • 82.73 (a)
Pop4 16
Pop4 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POP4 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POP4 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pop4 36
  • 83.48 (n)
  • 84.09 (a)
chicken
(Gallus gallus)
Aves POP4 36
  • 70.61 (n)
  • 69.09 (a)
POP4 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POP4 37
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3040 36
tropical clawed frog
(Silurana tropicalis)
Amphibia pop4 36
  • 63.62 (n)
  • 63.93 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.6289 36
pop4 36
  • 63.17 (n)
  • 63.93 (a)
pop4 37
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011713 36
  • 50.88 (n)
  • 44.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8038 36
  • 48.07 (n)
  • 39.86 (a)
CG8038 37
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C15C6.4 37
  • 24 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POP4 37
  • 20 (a)
OneToOne
POP4 39
Species with no ortholog for POP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POP4 Gene

ENSEMBL:
Gene Tree for POP4 (if available)
TreeFam:
Gene Tree for POP4 (if available)

Paralogs for POP4 Gene

No data available for Paralogs for POP4 Gene

Variants for POP4 Gene

Sequence variations from dbSNP and Humsavar for POP4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7283 -- 29,615,752(-) ATGTA(C/T)TGTAT utr-variant-3-prime, nc-transcript-variant
rs13767 -- 29,615,282(+) AAACC(A/G)ATGGC missense, reference, nc-transcript-variant
rs891060 -- 29,611,376(+) ACAGG(A/G)TATCA intron-variant
rs891061 -- 29,611,570(+) AACCT(C/T)AAAAT intron-variant
rs978173 -- 29,611,479(+) ACCAG(A/C)CTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POP4 Gene

Variant ID Type Subtype PubMed ID
nsv833799 CNV Gain 17160897

Relevant External Links for POP4 Gene

HapMap Linkage Disequilibrium report
POP4

Disorders for POP4 Gene

Relevant External Links for POP4

Genetic Association Database (GAD)
POP4
genes like me logo Genes that share disorders with POP4: view

No data available for UniProtKB/Swiss-Prot for POP4 Gene

Publications for POP4 Gene

  1. Rpp14 and Rpp29, two protein subunits of human ribonuclease P. (PMID: 10024167) Jarrous N. … Altman S. (RNA 1999) 2 3 4 23
  2. hPop4: a new protein subunit of the human RNase MRP and RNase P ribonucleoprotein complexes. (PMID: 10352175) van Eenennaam H. … van Venrooij W.J. (Nucleic Acids Res. 1999) 2 3 4 23
  3. Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. (PMID: 15096576) Welting T.J. … Pruijn G.J. (Nucleic Acids Res. 2004) 3 4
  4. Inhibition of the expression of the human RNase P protein subunits Rpp21, Rpp25, Rpp29 by external guide sequences (EGSs) and siRNA. (PMID: 15351636) Zhang H. … Altman S. (J. Mol. Biol. 2004) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for POP4 Gene

Sources for POP4 Gene

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