Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



POP4 Gene

protein-coding   GIFtS: 55
GCID: GC19P030097

Processing Of Precursor 4, Ribonuclease P/MRP Subunit (S....

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Processing Of Precursor 4, Ribonuclease P/MRP Subunit (S.
Cerevisiae)1 2
RPP292 3 5
hPOP42 3
EC 3.1.26.53 8
Ribonuclease P Protein Subunit P292

External Ids:    HGNC: 300811   Entrez Gene: 107752   Ensembl: ENSG000001051717   OMIM: 6061145   UniProtKB: O957073   

Export aliases for POP4 gene to outside databases

Previous GC identifers: GC19P030719 GC19P030546 GC19P034773 GC19P034789 GC19P026609


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for POP4 Gene:
This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the
endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is
localized to the nucleus and associates directly with the RNA component of these complexes. This protein is
involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. (provided
by RefSeq, Mar 2009)

GeneCards Summary for POP4 Gene:
POP4 (processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include ribonuclease P activity and RNA binding.

UniProtKB/Swiss-Prot: RPP29_HUMAN, O95707
Function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their
5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P

Gene Wiki entry for POP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the POP4 gene promoter:
         Bach1   HOXA9B   HOXA9   Bach2   Tal-1beta   NF-AT   AREB6   Meis-1a   ITF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOP4 promoter sequence
   Search Chromatin IP Primers for POP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q12   Ensembl cytogenetic band:  19q12   HGNC cytogenetic band: 19q13.11

POP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POP4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P030097:  view genomic region     (about GC identifiers)

Start:
30,094,924 bp from pter      End:
30,108,162 bp from pter
Size:
13,239 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RPP29_HUMAN, O95707 (See protein sequence)
Recommended Name: Ribonuclease P protein subunit p29  
Size: 220 amino acids; 25425 Da
Subunit: Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at
least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists
of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38,
RPP40, POP5 and RPP21. Interacts with RPP25 and POP5
Secondary accessions: Q5XKL7 Q6FHW9 Q9UQQ3

Explore the universe of human proteins at neXtProt for POP4: NX_O95707

Explore proteomics data for POP4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for POP4 (O95707) (see all 5)
     TGILLQETKH  SERSAKKFKAKG  LKVIPKLNCVFT  QRAEAFVRAFLK 


    See POP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006618.1  
    ENSEMBL proteins: 
     ENSP00000465213   ENSP00000468215   ENSP00000468718   ENSP00000221770   ENSP00000465456  
     ENSP00000467990   ENSP00000376104  

    POP4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for POP4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for POP4
    GenScript Custom Purified and Recombinant Proteins Services for POP4
    Novus Biologicals POP4 Proteins
    Novus Biologicals POP4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for POP4
    Cloud-Clone Corp. Proteins for POP4

     
    Search eBioscience for Proteins for POP4 

    POP4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for POP4
    Novus Biologicals POP4 Antibodies
    Abcam antibodies for POP4
    Cloud-Clone Corp. Antibodies for POP4
    Search ThermoFisher Antibodies for POP4
    LSBio Antibodies in human, mouse, rat for POP4

    POP4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for POP4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for POP4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for POP4
    Cloud-Clone Corp. CLIAs for POP4
    Search eBioscience for ELISAs for POP4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR016848 RNase_P/MRP_p29-subunit
     IPR023534 Rof/RNase_P-like
     IPR002730 RNase_P/MRP_p29

    Graphical View of Domain Structure for InterPro Entry O95707

    ProtoNet protein and cluster: O95707

    1 Blocks protein domain: IPB002730 Protein of unknown function UPF0086

    UniProtKB/Swiss-Prot: RPP29_HUMAN, O95707
    Similarity: Belongs to the eukaryotic/archaeal RNase P protein component 1 family


    Find genes that share domains with POP4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPP29_HUMAN, O95707
    Function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their
    5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P
    Catalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor

         Enzyme Number (IUBMB): EC 3.1.26.51 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0004526ribonuclease P activity IEA--
    GO:0004540ribonuclease activity ----
    GO:0005515protein binding IPI15096576
         
    Find genes that share ontologies with POP4           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pop4):
     mortality/aging 

    Find genes that share phenotypes with POP4           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POP4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for POP4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POP4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POP4

    miRNA
    Products:
        
    miRTarBase miRNAs that target POP4:
    hsa-mir-92a-3p (MIRT049425), hsa-mir-128-3p (MIRT045865), hsa-mir-26b-5p (MIRT029286)

    Block miRNA regulation of human, mouse, rat POP4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate POP4 (see all 16):
    hsa-miR-4303 hsa-miR-4291 hsa-miR-875-3p hsa-miR-548p hsa-miR-1263 hsa-miR-516b hsa-miR-15a hsa-miR-497
    SwitchGear 3'UTR luciferase reporter plasmidPOP4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for POP4
    Predesigned siRNA for gene silencing in human, mouse, rat POP4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for POP4

    Clone
    Products:
         
    OriGene clones in human, mouse for POP4 (see all 7)
    OriGene ORF clones in mouse, rat for POP4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POP4 (NM_006627)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POP4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for POP4
    Browse ESI BIO Cell Lines and PureStem Progenitors for POP4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POP4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RPP29_HUMAN, O95707: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000172ribonuclease MRP complex IEA--
    GO:0005655nucleolar ribonuclease P complex IEA--
    GO:0030677ribonuclease P complex ----

    Find genes that share ontologies with POP4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for POP4 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA transport
    RNA transport
    2Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes


    Find genes that share SuperPaths with POP4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for POP4):
        Ribosome biogenesis in eukaryotes
    RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POP4
    Interactions:

        GeneGlobe Interaction Network for POP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for POP4 (O957071, 3 ENSP000002217704) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPP25Q9BUL91, 3, ENSP000003176914EBI-366477,EBI-366570 I2D: score=4 STRING: ENSP00000317691
    POP5Q969H61, 3, ENSP000003500984EBI-366477,EBI-366525 I2D: score=5 STRING: ENSP00000350098
    RPP38P783451, 3, ENSP000003674394EBI-366477,EBI-366493 I2D: score=5 STRING: ENSP00000367439
    POP1Q995751, 3, ENSP000003395294EBI-366477,EBI-366741 I2D: score=5 STRING: ENSP00000339529
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--
    GO:0006379mRNA cleavage IEA--
    GO:0008033tRNA processing IEA--
    GO:0090501RNA phosphodiester bond hydrolysis TAS10352175
    GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic TAS10352175

    Find genes that share ontologies with POP4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POP4 (RPP29)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for POP4 gene: 
    NM_006627.2  

    Unigene Cluster for POP4:

    Processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
    Hs.412870  [show with all ESTs]
    Unigene Representative Sequence: NM_006627
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585603 ENST00000586173 ENST00000586420 ENST00000591061 ENST00000221770(uc002nsf.2 uc002nsg.2)
    ENST00000586823 ENST00000591824 ENST00000588551 ENST00000590688 ENST00000586136
    ENST00000592759 ENST00000592749 ENST00000587232 ENST00000392279
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat POP4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate POP4 (see all 16):
    hsa-miR-4303 hsa-miR-4291 hsa-miR-875-3p hsa-miR-548p hsa-miR-1263 hsa-miR-516b hsa-miR-15a hsa-miR-497
    SwitchGear 3'UTR luciferase reporter plasmidPOP4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for POP4
    Predesigned siRNA for gene silencing in human, mouse, rat POP4
    Clone
    Products:
         
    OriGene clones in human, mouse for POP4 (see all 7)
    OriGene ORF clones in mouse, rat for POP4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POP4 (NM_006627)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POP4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for POP4
    OriGene qSTAR qPCR primer pairs in human, mouse for POP4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POP4
      QuantiTect SYBR Green Assays in human, mouse, rat POP4
      QuantiFast Probe-based Assays in human, mouse, rat POP4

    Additional mRNA sequence: 

    AF001176.2 AK090872.1 AK314790.1 BC004438.1 BC006098.1 BC013686.1 CR536569.1 CR936714.1 
    NR_027368.1 Y18863.1 

    12 DOTS entries:

    DT.219248  DT.92021320  DT.311374  DT.75172550  DT.121489407  DT.92435932  DT.99933112  DT.121489402 
    DT.95197196  DT.121489345  DT.92392293  DT.95197195 

    Selected AceView cDNA sequences (see all 277):

    BI116633 AA570404 BE746054 CF131080 CB141661 AA934656 CB141662 BQ576333 
    BM766302 BE746099 AA480963 AI338156 BQ082298 BU736548 AA987278 BE514857 
    BU848772 BX446078 BF434997 CD370529 BC006098 CD673378 CN482672 CB115592 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for POP4 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e · 10f
    SP1:              -           -     -     -     -     -                 -                 -     -                                                   
    SP2:                          -     -                 -                 -                                                                           
    SP3:              -           -     -     -     -     -           -     -     -           -     -                                                   
    SP4:              -           -     -     -     -     -                 -                 -     -                                                   
    SP5:                                                  -                 -                 -     -                                                   


    ECgene alternative splicing isoforms for POP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    POP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCTGAGT
    POP4 Expression
    About this image

    POP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.412870
        Custom PCR Arrays for POP4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for POP4
    OriGene qSTAR qPCR primer pairs in human, mouse for POP4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POP4
    QuantiTect SYBR Green Assays in human, mouse, rat POP4
    QuantiFast Probe-based Assays in human, mouse, rat POP4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for POP4 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pop41 , 5 processing of precursor 4, ribonuclease P/MRP family, more1, 5 82.58(n)1
    82.73(a)1
      7 (25.36 cM)5
    661611  NM_025390.41  NP_079666.11 
     382628205 
    chicken
    (Gallus gallus)
    Aves POP41 processing of precursor 4, ribonuclease P/MRP subunit more 70.61(n)
    69.09(a)
      768362  NM_001145914.1  NP_001139386.1 
    lizard
    (Anolis carolinensis)
    Reptilia POP46
    processing of precursor 4, ribonuclease P/MRP subu...
    70(a)
    1 ↔ 1
    GL343874.1(201182-201322)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.30402 Xenopus laevis transcribed sequence with weak similarity more 73.85(n)    CA789008.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.62892 Transcribed sequence with weak similarity to protein more 72.94(n)    57059031 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG80381 CG8038 48.07(n)
    39.86(a)
      38889  NM_139911.3  NP_648168.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C15C6.46
    Protein C15C6.4 (C15C6.4) mRNA, complete cds
    24(a)
    1 ↔ 1
    I(12213109-12215184) WBGene00007603
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes POP4(YBR257W)4 Subunit of both RNase MRP and nuclear RNase P; RNase more   --   2(728885-729724) 852560  NP_009816.1 


    ENSEMBL Gene Tree for POP4 (if available)
    TreeFam Gene Tree for POP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for POP4 (see all 375)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs116720191,2
    C,F,H--30095182(+) gagatG/Cacacc 2 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1438919791,2
    C--30095239(+) AAAAA-/TATTTT 2 -- us2k10--------
    rs563152731,2
    C--30095241(+) AAATAC/TTTTAA 2 -- us2k10--------
    rs1425281381,2
    --30095312(+) AATTCA/GAGGGG 2 -- us2k10--------
    rs1817004461,2
    --30095343(+) ATCCCA/CGAAGG 2 -- us2k10--------
    rs1460042091,2
    --30095553(+) TGGTGA/GCTATA 2 -- us2k10--------
    rs116690681,2
    C,F,A,H--30095816(+) GTTTAA/CATGTG 2 -- us2k128Minor allele frequency- C:0.18NS EA NA WA 3244
    rs3708000611,2
    C--30095816(+) GTTTA-/A/CATGTG 2 -- us2k10--------
    rs1867124991,2
    --30095853(+) ATAAAC/TGCATA 2 -- us2k10--------
    rs169630851,2
    C,F,H--30095911(+) TGCACG/TCGGGG 2 -- us2k1 tfbs316Minor allele frequency- T:0.09NA NS EA WA 2078

    HapMap Linkage Disequilibrium report for POP4 (30094924 - 30108162 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for POP4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833799CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POP4
    DNA2.0 Custom Variant and Variant Library Synthesis for POP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606114    OMIM disorders: --


    Find genes that share disorders with POP4           About GenesLikeMe

    Genetic Association Database (GAD): POP4

    Export disorders for POP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for POP4 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with POP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rpp14 and Rpp29, two protein subunits of human ribonuclease P. (PubMed id 10024167)1, 2, 3, 9 Jarrous N.... Altman S. (RNA 1999)
    2. hPop4: a new protein subunit of the human RNase MRP and RNase P ribonucleoprotein complexes. (PubMed id 10352175)1, 2, 3, 9 van Eenennaam H.... van Venrooij W.J. (Nucleic Acids Res. 1999)
    3. Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. (PubMed id 15096576)1, 2 Welting T.J.... Pruijn G.J. (Nucleic Acids Res. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Inhibition of the expression of the human RNase P protein subunits Rpp21, Rpp25, Rpp29 by external guide sequences (EGSs) and siRNA. (PubMed id 15351636)1, 9 Zhang H. and Altman S. (J. Mol. Biol. 2004)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (Science 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10775 HGNC: 30081 AceView: POP4 Ensembl:ENSG00000105171 euGenes: HUgn10775
    ECgene: POP4 Kegg: 10775 H-InvDB: POP4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for POP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for POP4 gene:
    Search GeneIP for patents involving POP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for POP4  
     OriGene qPCR primer pairs and template standards for POP4   OriGene Protein Over-expression Lysate for POP4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for POP4  
     OriGene qSTAR qPCR primer pairs in human, mouse for POP4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for POP4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for POP4   OriGene Custom Protein Services for POP4  

     
     
     Block miRNA regulation of human, mouse, rat POP4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing POP4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POP4 Predesigned siRNA for gene silencing in human, mouse, rat POP4
     QuantiFast Probe-based Assays in human, mouse, rat POP4 QuantiTect SYBR Green Assays in human, mouse, rat POP4
     Custom PCR Arrays for POP4 Search Chromatin IP Primers for POP4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POP4  GeneGlobe Interaction Network for POP4
     Regulatory tfbs in POP4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for POP4 GenScript cDNA clones with any tag delivered in your preferred vector for POP4
     GenScript Custom Assay Services for POP4 GenScript Custom overexpressing Cell Line Services for POP4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for POP4 (RPP29)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     POP4 antibodies
     POP4 proteins
     POP4 lysates
     Antibodies for POP4
     See all of Abcam's Antibodies, Kits and Proteins for POP4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for POP4
     Proteins for POP4
     Antibodies for POP4
     ELISAs for POP4
     CLIAs for POP4



     Browse ESI BIO Cell Lines and PureStem Progenitors for POP4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POP4
     SwitchGear 3'UTR luciferase reporter plasmids for POP4
     SwitchGear Promoter luciferase reporter plasmids for POP4
     Search ThermoFisher Antibodies for POP4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POP4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POP4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for POP4
     LSBio Antibodies in human, mouse, rat for POP4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for POP4
      Search eBioscience for proteins for POP4
      Search eBioscience for elisas for POP4
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      POP4 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4