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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POP4 Gene

protein-coding   GIFtS: 53
GCID: GC19P030097

processing of precursor 4, ribonuclease P/MRP subunit (S....
 Explore 1 disease affiliated with
POP4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for POP4    

Aliases
for POP4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Processing Of Precursor 4, Ribonuclease P/MRP Subunit (S. Cerevisiae)1 2
RPP291 2 3 5
HPOP41
EC 3.1.26.53 8
Ribonuclease P Protein Subunit P292

External Ids:    HGNC: 300811   Entrez Gene: 107752   Ensembl: ENSG000001051717   OMIM: 6061145   UniProtKB: O957073   
ORGUL members:         
NONCODE:n407825    

Export aliases for POP4 gene to outside databases

Previous GC identifers: GC19P030719 GC19P030546 GC19P034773 GC19P034789 GC19P026609


Summaries
for POP4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for POP4:
This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease
for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the
nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of
precursor RNAs. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: RPP29_HUMAN, O95707
Function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May
function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P

Gene Wiki entry for POP4


Genomic Views
for POP4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POP4 gene promoter:
         Bach1   HOXA9B   HOXA9   Bach2   Tal-1beta   NF-AT   AREB6   Meis-1a   ITF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: POP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for POP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q12   Ensembl cytogenetic band:  19q12   HGNC cytogenetic band: 19q13.11

POP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POP4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P030097:  view genomic region     (about GC identifiers)

Start:
 30,094,924 bp from pter      End:
 30,108,162 bp from pter
Size:
 13,239 bases      Orientation:
 plus strand

Proteins
for POP4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RPP29_HUMAN, O95707 (See protein sequence)
Recommended Name: Ribonuclease P protein subunit p29  
Size: 220 amino acids; 25425 Da
Subunit: Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a RNA moiety and at least 8
protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of a RNA
moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and
RPP21. Interacts with RPP25 and POP5
Subcellular location: Nucleus, nucleolus
Secondary accessions: Q5XKL7 Q6FHW9 Q9UQQ3

Explore the universe of human proteins at neXtProt for POP4: NX_O95707

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95707

    • 4/5 DME Specific Peptides for POP4 (O95707) (see all 5)
     TGILLQETKH  SERSAKKFKAKG  LKVIPKLNCVFT  QRAEAFVRAFLK 

    POP4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006618.1  
    ENSEMBL proteins: 
     ENSP00000465213   ENSP00000468215   ENSP00000468718   ENSP00000221770   ENSP00000465456  
     ENSP00000467990   ENSP00000376104  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: POP4
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    Novus Biologicals POP4 Proteins
    Novus Biologicals POP4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for POP4

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000172ribonuclease MRP complex IEA--
    GO:0005655nucleolar ribonuclease P complex IEA--
    GO:0030677ribonuclease P complex ----


    POP4 for ontologies           About GeneDecksing



    POP4 Antibody Products: 
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    Uscn Antibodies for POP4
    Search ThermoFisher Antibodies for POP4

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    Uscn ELISAs and CLIAs for POP4

    Protein Domains /
    Families
    for POP4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    POP4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016848 RNase_P/MRP_p29-subunit
     IPR023534 Rof/RNase_P-like
     IPR002730 RNase_P/MRP_p29

    Graphical View of Domain Structure for InterPro Entry O95707

    ProtoNet protein and cluster: O95707

    1 Blocks protein family: IPB002730 Protein of unknown function UPF0086

    UniProtKB/Swiss-Prot: RPP29_HUMAN, O95707
    Similarity: Belongs to the eukaryotic/archaeal RNase P protein component 1 family


    Function
    for POP4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RPP29_HUMAN, O95707
    Function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May
    function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P
    Catalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor

    Enzyme Number (IUBMB): EC 3.1.26.51 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone: POP4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POP4
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate POP4 (see all 16):
    hsa-miR-4303 hsa-miR-4291 hsa-miR-875-3p hsa-miR-548p hsa-miR-1263 hsa-miR-516b hsa-miR-15a hsa-miR-497
    SwitchGear 3'UTR luciferase reporter plasmid: POP4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POP4 (see all 7)
    OriGene shRNA RFP: POP4
    OriGene siRNA: POP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POP4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for POP4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POP4 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: POP4 (NM_006627)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POP4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for POP4
    Search LifeMap BioReagents cell lines for POP4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POP4

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0004526ribonuclease P activity IEA--
    GO:0004540ribonuclease activity ----
    GO:0005515protein binding IPI15096576


    POP4 for ontologies           About GeneDecksing



    Pathways & Interactions
    for POP4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ribosome biogenesis in eukaryotes
    		Ribosome biogenesis in eukaryotes1.00
    2RNA transport
    		RNA transport1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for POP4):
        Ribosome biogenesis in eukaryotes
    RNA transport


    POP4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/12 Interacting proteins for POP4 (O957071, 3 ENSP000002217704) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPP25Q9BUL91, 3, ENSP000003176914EBI-366477,EBI-366570 I2D: score=4 STRING: ENSP00000317691
    POP5Q969H61, 3, ENSP000003500984EBI-366477,EBI-366525 I2D: score=5 STRING: ENSP00000350098
    RPP38P783451, 3, ENSP000003674394EBI-366477,EBI-366493 I2D: score=5 STRING: ENSP00000367439
    POP1Q995751, 3, ENSP000003395294EBI-366477,EBI-2560204 I2D: score=5 STRING: ENSP00000339529
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--
    GO:0006379mRNA cleavage IEA--
    GO:0008033tRNA processing IEA--


    POP4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for POP4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POP4
    Search CenterWatch for drugs/clinical trials and news about POP4 / RPP29 

    Transcripts
    for POP4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for POP4 gene: 
    NM_006627.2  

    Unigene Cluster for POP4:

    Processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
    Hs.412870  [show with all ESTs]
    Unigene Representative Sequence: NM_006627
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585603 ENST00000586173 ENST00000586420 ENST00000591061 ENST00000221770(uc002nsf.2 uc002nsg.2)
    ENST00000586823 ENST00000591824 ENST00000588551 ENST00000590688 ENST00000586136
    ENST00000592759 ENST00000592749 ENST00000587232 ENST00000392279

    miRNA
    Products:             		 OriGene 3'-UTR Clone: POP4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POP4
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate POP4 (see all 16):
    hsa-miR-4303 hsa-miR-4291 hsa-miR-875-3p hsa-miR-548p hsa-miR-1263 hsa-miR-516b hsa-miR-15a hsa-miR-497
    SwitchGear 3'UTR luciferase reporter plasmid: POP4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POP4 (see all 7)
    OriGene shRNA RFP: POP4
    OriGene siRNA: POP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POP4
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POP4 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: POP4 (NM_006627)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POP4 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POP4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POP4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POP4

    Additional cDNA sequence: 

    AF001176.2 AK090872.1 AK314790.1 BC004438.1 BC006098.1 BC013686.1 CR536569.1 CR936714.1 
    NR_027368.1 Y18863.1 

    12 DOTS entries:

    DT.219248  DT.92021320  DT.311374  DT.75172550  DT.121489407  DT.99933112  DT.121489402  DT.95197196 
    DT.121489345  DT.92392293  DT.92435932  DT.95197195 

    24/277 AceView cDNA sequences (see all 277):

    BE739895 BE904258 BM726033 BQ428458 BG261204 CR536569 CN482672 CB141661 
    BG697335 AI091498 AI338156 BM756281 BQ576333 Y18863 BE514857 BF513277 
    CD370529 BM766302 BM976053 BM704237 CD673378 AA987278 AA570404 BM985094 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for POP4 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e · 10f
    SP1:              -           -     -     -     -     -                 -                 -     -                                                   
    SP2:                          -     -                 -                 -                                                                           
    SP3:              -           -     -     -     -     -           -     -     -           -     -                                                   
    SP4:              -           -     -     -     -     -                 -                 -     -                                                   
    SP5:                                                  -                 -                 -     -                                                   


    ECgene alternative splicing isoforms for POP4

    Expression
    for POP4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTCTGAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See POP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POP4

    SOURCE GeneReport for Unigene cluster: Hs.412870
        SABiosciences Custom PCR Arrays for POP4
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POP4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POP4

    Orthologs
    for POP4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for POP4 gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Pop41 , 5 processing of precursor 4, ribonuclease P/MRP family, more1, 5 83.03(n)1
    83.18(a)1    		   7 (25.36 cM)5
    661611  NM_025390.41  NP_079666.11 
     382628205 
    chicken
    (Gallus gallus)    		 Aves POP41 processing of precursor 4, ribonuclease P/MRP subunit more 70.61(n)
    69.09(a)    		   768362  NM_001145914.1  NP_001139386.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.30402 Xenopus laevis transcribed sequence with weak similarity more 73.85(n)    CA789008.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.62892 Transcribed sequence with weak similarity to protein more 72.94(n)    57059031 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG80381 CG8038 47.24(n)
    39.07(a)    		   38889  NM_139911.2  NP_648168.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea C15C6.46
    		 Protein C15C6.4
    		 21(a)
    		 1 ↔ 1
    		 I(12213100-12215175)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G431906
    		 ribonuclease P-like protein
    		 16(a)
    		 1 ↔ 1
    		 2(17955984-17958041)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 ribonuclease P family protein, putative, expressed...
    		 16(a)
    		 1 ↔ 1
    		 5(23133575-23138906)


    ENSEMBL Gene Tree for POP4 (if available)
    TreeFam Gene Tree for POP4 (if available) 

    Paralogs
    for POP4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for POP4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/305 NCBI SNPs in POP4 are shown (see all 305)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs116720191,2
    		C,H,--30095182(+) gagatG/Cacacc 2 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1438919791,2
    		C,--30095239(+) AAAAA-/TATTTT 2 -- us2k10--------
    rs563152731,2
    		C--30095241(+) AAATAC/TTTTAA 2 -- us2k10--------
    rs1425281381,2
    		--30095312(+) AATTCA/GAGGGG 2 -- us2k10--------
    rs1817004461,2
    		--30095343(+) ATCCCA/CGAAGG 2 -- us2k10--------
    rs1460042091,2
    		--30095553(+) TGGTGA/GCTATA 2 -- us2k10--------
    rs768296521,2
    		C,--30095816(+) GTTTAA/CATGTG 2 -- us2k15Minor allele frequency- C:0.18NA WA EA 362
    rs1867124991,2
    		--30095853(+) ATAAAC/TGCATA 2 -- us2k10--------
    rs169630851,2
    		C,F,H,--30095911(+) TGCACG/TCGGGG 2 -- us2k1 tfbs316Minor allele frequency- T:0.09NA NS EA WA 2078
    rs1382767421,2
    		--30095940(+) TTCAGC/TGCCTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for POP4 (30094924 - 30108162 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for POP4: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for POP4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    POP4 for disorders           About GeneDecksing

    OMIM gene information: 606114    OMIM disorders: --

    1 disease for POP4:    About MalaCards
    malaria


    Export disorders for POP4 gene to outside databases

    Publications
    for POP4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POP4 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with POP4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Rpp14 and Rpp29, two protein subunits of human ribonuclease P. (PubMed id 10024167)1, 2, 3, 9 Jarrous N.... Altman S. (1999)
    2. hPop4: a new protein subunit of the human RNase MRP and RNase P ribonucleoprotein complexes. (PubMed id 10352175)1, 2, 3, 9 van Eenennaam H.... van Venrooij W.J. (1999)
    3. Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. (PubMed id 15096576)1, 2 Welting T.J.... Pruijn G.J. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Inhibition of the expression of the human RNase P protein subunits Rpp21, Rpp25, Rpp29 by external guide sequences (EGSs) and siRNA. (PubMed id 15351636)1, 9 Zhang H. and Altman S. (2004)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)
    10. Differential association of protein subunits with the human RNase MRP and RNase P complexes. (PubMed id 16723659)1 Welting T.J....Pruijn G.J. (2006)

    External Searches for POP4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing POP4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10775 HGNC: 30081 AceView: POP4 Ensembl:ENSG00000105171 euGenes: HUgn10775
    ECgene: POP4 Kegg: 10775 H-InvDB: POP4

    Other Databases showing POP4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing POP4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POP4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for POP4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for POP4 gene:
    Search GeneIP for patents involving POP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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     Regulatory tfbs in POP4 promoter
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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