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PON3 Gene

protein-coding   GIFtS: 63
GCID: GC07M094989

Paraoxonase 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Paraoxonase 31 2     EC 3.1.1.23
Arylesterase 31 2     EC 3.1.1.813
paraoxanase-32     EC 3.1.8.13
Serum Paraoxonase/Lactonase 32     

External Ids:    HGNC: 92061   Entrez Gene: 54462   Ensembl: ENSG000001058527   OMIM: 6027205   UniProtKB: Q151663   

Export aliases for PON3 gene to outside databases

Previous GC identifers: GC07M093524 GC07M094587 GC07M094601 GC07M094633 GC07M094827 GC07M089596


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PON3 Gene:
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family
members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL).
The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a
function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced
variants which encode different protein isoforms have been described; however, only one has been fully
characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for PON3 Gene:
PON3 (paraoxonase 3) is a protein-coding gene. Diseases associated with PON3 include atherosclerosis, and amyotrophic lateral sclerosis. GO annotations related to this gene include aryldialkylphosphatase activity and protein homodimerization activity. An important paralog of this gene is PON1.

UniProtKB/Swiss-Prot: PON3_HUMAN, Q15166
Function: Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly
hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member
ring lactones with aliphatic substituents but not simple lactones or those with polar substituents

Gene Wiki entry for PON3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PON3 gene promoter:
         c-Fos   AP-1   JunB   FosB   Fra-1   POU6F1 (c2)   LCR-F1   GATA-1   JunD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PON3 promoter sequence
   Search Chromatin IP Primers for PON3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PON3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.3   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q21.3

PON3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PON3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M094989:  view genomic region     (about GC identifiers)

Start:
94,989,184 bp from pter      End:
95,025,687 bp from pter
Size:
36,504 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 94,318,186-94,354,692     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PON3_HUMAN, Q15166 (See protein sequence)
Recommended Name: Serum paraoxonase/lactonase 3  
Size: 354 amino acids; 39607 Da
Cofactor: Binds 2 calcium ions per subunit (By similarity)
Subunit: Homodimer
Secondary accessions: A4D1H8 O75855 O76060 Q6IRU9 Q8IX97 Q9BZH9

Explore the universe of human proteins at neXtProt for PON3: NX_Q15166

Explore proteomics data for PON3 at MOPED

Post-translational modifications: 

  • The signal sequence is not cleaved (By similarity)1
  • Glycosylation2 at Asn29, Asn269, Asn323
  • Modification sites at PhosphoSitePlus

  • See PON3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000931.1  
    ENSEMBL proteins: 
     ENSP00000265627   ENSP00000413276   ENSP00000403850   ENSP00000393174   ENSP00000390253  
     ENSP00000391072  

    PON3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for PON3
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    Novus Biologicals PON3 Protein
    Novus Biologicals PON3 Lysates
    Sino Biological Recombinant Protein for PON3
    Sino Biological Cell Lysate for PON3
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    Cloud-Clone Corp. Proteins for PON3

    PON3 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for PON3

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    Cloud-Clone Corp. ELISAs for PON3
    Cloud-Clone Corp. CLIAs for PON3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PON: Paraoxonases

    3 InterPro protein domains:
     IPR008364 Paraoxonase2
     IPR002640 Arylesterase
     IPR011042 6-blade_b-propeller_TolB-like

    Graphical View of Domain Structure for InterPro Entry Q15166

    ProtoNet protein and cluster: Q15166

    1 Blocks protein domain: IPB002640 Arylesterase

    UniProtKB/Swiss-Prot: PON3_HUMAN, Q15166
    Similarity: Belongs to the paraoxonase family


    PON3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PON3_HUMAN, Q15166
    Function: Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly
    hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member
    ring lactones with aliphatic substituents but not simple lactones or those with polar substituents
    Catalytic activity: A phenyl acetate + H(2)O = a phenol + acetate
    Catalytic activity: An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol
    Catalytic activity: An N-acyl-L-homoserine lactone + H(2)O = an N-acyl-L-homoserine

         Genatlas biochemistry entry for PON3:
    paraoxonase-like sequence 2(PON3)

         Enzyme Numbers (IUBMB): EC 3.1.1.21 EC 3.1.1.811 EC 3.1.8.11

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004063aryldialkylphosphatase activity IEA--
    GO:0004064arylesterase activity NAS8661009
    GO:0016844strictosidine synthase activity ----
    GO:00187333,4-dihydrocoumarin hydrolase activity IEA--
    GO:0042803protein homodimerization activity IDA15772423
         
    PON3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PON3:
     Increased gamma-H2AX phosphory  Increased number of cells in m 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pon3):
     cellular  embryogenesis  growth/size/body  homeostasis/metabolism  mortality/aging 

    PON3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pon3tm1Lus for PON3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PON3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PON3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PON3

    miRNA
    Products:
        
    miRTarBase miRNAs that target PON3:
    hsa-mir-335-5p (MIRT017621)

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    Predesigned siRNA for gene silencing in human, mouse, rat PON3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: PON3 (NM_000940)
    Sino Biological Human cDNA Clone for PON3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PON3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PON3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PON3_HUMAN, Q15166: Secreted, extracellular space (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum2
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0043231intracellular membrane-bounded organelle IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    PON3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PON3 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38
    2Phase I, non P450
    Phase I, non P450

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PON3
        Phase I, non P450



    1 Kegg Pathway  (Kegg details for PON3):
        Metabolic pathways


    PON3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including PON3: 
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PON3

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009058biosynthetic process ----
    GO:0009605response to external stimulus NAS8661009
    GO:0010124phenylacetate catabolic process IEA--
    GO:0019439aromatic compound catabolic process IDA15772423
    GO:0046226coumarin catabolic process IEA--

    PON3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PON3

    Selected HMDB Compounds for PON3 (see all 19)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    4-Nitrophenol1-Hydroxy-4-nitrobenzene (see all 8)100-02-7--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Acetic acidAcetate (see all 12)64-19-7--
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    DiethylthiophosphateDETP (see all 6)5871-17-0--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--

    2 DrugBank Compounds for PON3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Edetic AcidCaEDTA (see all 8)62-33-9enzymeinhibitor17292339
    Lovastatin6 alpha-Methylcompactin (see all 4)75330-75-5enzymesubstrate10931838

    4 Novoseek inferred chemical compound relationships for PON3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phenylacetate 83.7 1 11304470 (1)
    paraoxon 76.9 1 11304470 (1)
    lovastatin 36.5 1 15772423 (1)
    cholesterol 33.1 2 18585453 (2)



    PON3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PON3 gene: 
    NM_000940.2  

    Unigene Cluster for PON3:

    Paraoxonase 3
    Hs.440967  [show with all ESTs]
    Unigene Representative Sequence: CD014095
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265627(uc003unt.3) ENST00000427422 ENST00000451904 ENST00000418617
    ENST00000442770 ENST00000456855 ENST00000492800 ENST00000460248 ENST00000482624(uc011kii.2)
    ENST00000475439
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PON3
      QuantiFast Probe-based Assays in human, mouse, rat PON3

    Additional mRNA sequence: 

    AF320003.1 AF329433.1 AK304282.1 BC020908.1 BC070374.1 L48516.1 

    18 DOTS entries:

    DT.313453  DT.92425664  DT.92425663  DT.101983699  DT.40121264  DT.101983703  DT.92425666  DT.100731698 
    DT.100738978  DT.100762569  DT.101983700  DT.101983701  DT.40121265  DT.92425659  DT.92425662  DT.100653477 
    DT.101983702  DT.75151092 

    Selected AceView cDNA sequences (see all 80):

    BF513914 AV653103 AF329433 AI074616 AV660394 CD014102 AI674127 CD014096 
    AV660412 AI247797 AA973222 CB160649 BF059348 CD014100 CD014099 AV658512 
    BE504490 AA494323 AI866606 AI033844 CD014095 NM_000940 T81888 BU071352 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PON3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAAATTCT
    PON3 Expression
    About this image


    PON3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    PON3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PON3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.440967
        Pathway & Disease-focused RT2 Profiler PCR Array including PON3: 
              Drug Metabolism in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for PON3
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    QuantiFast Probe-based Assays in human, mouse, rat PON3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PON3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PON3 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pon31 , 5 paraoxonase 31, 5 83.71(n)1
    81.36(a)1
      6 (1.99 cM)5
    2698231  NM_173006.11  NP_766594.11 
     52208525 
    chicken
    (Gallus gallus)
    Aves PON26
    serum paraoxonase/arylesterase 2 precursor
    65(a)
    1 → many
    2(23977867-23996726)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    55(a)
    1 → many
    6(22503357-22522885)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1746376
    pon26
    (see all 4)
    paraoxonase 2
    (see all 4)
    50(a)
    50(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    16(26896251-26900819) ENSDARG00000097789
    16(26909176-26912212) ENSDARG00000016856
    worm
    (Caenorhabditis elegans)
    Secernentea poml-21 poml-2 44.38(n)
    30.65(a)
      171999  NM_058905.4  NP_491306.1 


    ENSEMBL Gene Tree for PON3 (if available)
    TreeFam Gene Tree for PON3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PON3 gene
    PON12  PON22  
    2 SIMAP similar genes for PON3 using alignment to 5 protein entries:     PON3_HUMAN (see all proteins):
    PON2    PON1

    PON3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PON3 (see all 821)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113889511,2
    C--94998126(+) AAAAA-/AGAAAG 1 -- int1 trp31Minor allele frequency- A:0.50NA 2
    rs345824901,2
    C--95008390(+) AAAAAA/-GCAGG 1 -- int11Minor allele frequency- -:0.00NA 2
    rs178786611,2
    C,F--95020175(-) GTGTAG/-GTGAC 1 -- int12Minor allele frequency- -:0.06NS 88
    rs113781291,2
    C--95023616(+) AGAAAG/-GAAGC 1 -- int1 trp32Minor allele frequency- -:0.00NA CSA 6
    rs1139965391,2
    F--98295383(+) GTGTCG/AGTACC 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1929560341,2
    --98295549(+) GGACTA/GTAGGA 1 -- ds50010--------
    rs178826431,2
    C,F--98295593(-) TAACTG/AGGTCC 1 -- ds50012Minor allele frequency- A:0.01NS 82
    rs1840269091,2
    --98295688(+) AGATCC/TGTAAA 1 -- ds50010--------
    rs178855581,2
    C,F--98295869(-) GTCTAC/TATATT 1 -- ut3110Minor allele frequency- T:0.03NS NA WA CSA EA EU 1225
    rs1458807901,2
    C--98295901(+) TCTAGA/GGTCTA 1 -- ut311Minor allele frequency- G:0.00EU 1293

    HapMap Linkage Disequilibrium report for PON3 (94989184 - 95025687 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PON3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660407CNV Deletion23128226
    nsv888740CNV Gain21882294
    nsv888743CNV Gain21882294

    Human Gene Mutation Database (HGMD): PON3
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602720    OMIM disorders: --

    16 diseases for PON3:    
    About MalaCards
    atherosclerosis    amyotrophic lateral sclerosis    coronary heart disease    vascular dementia
    acute myocardial infarction    lateral sclerosis    cataract    coronary artery disease
    myocardial infarction    dementia    obesity    alzheimer's disease
    systemic lupus erythematosus    lupus erythematosus    colorectal cancer    hepatocellular carcinoma

    1 disease from the University of Copenhagen DISEASES database for PON3:
    Atherosclerosis

    PON3 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for PON3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 60 13 17446441 (3), 17379834 (2), 11304457 (1), 19359600 (1) (see all 9)
    coronary heart disease 43.4 2 11803456 (1), 16120573 (1)
    cardiovascular diseases 37.3 2 11803456 (1), 19082953 (1)
    stroke 0 1 16239632 (1)

    Genetic Association Database (GAD): PON3
    Human Genome Epidemiology (HuGE) Navigator: PON3 (36 documents)

    Export disorders for PON3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PON3 gene, integrated from 10 sources (see all 102):
    (articles sorted by number of sources associating them with PON3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. (PubMed id 8661009)1, 2, 3, 9 Primo-Parmo S.L.... La Du B.N. (Genomics 1996)
    2. Genetic variation in the paraoxonase-3 (PON3) gene is associated with serum PON1 activity. (PubMed id 17900266)1, 4, 9 Sanghera D.K....Kamboh M.I. (Ann. Hum. Genet. 2008)
    3. Identification of paraoxonase 3 gene (PON3) missense mutations in a population of southern Italy. (PubMed id 14757195)1, 4, 9 Campo S....Saitta A. (Mutat. Res. 2004)
    4. Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. (PubMed id 15772423)1, 2, 9 Draganov D.I....La Du B.N. (J. Lipid Res. 2005)
    5. Paraoxonase gene polymorphisms and haplotype analysis in a stroke population. (PubMed id 16551349)1, 4, 9 Pasdar A....MacLeod M.J. (BMC Med. Genet. 2006)
    6. Paraoxonase gene cluster variations associated with coronary heart disease in Chinese Han women. (PubMed id 16117861)1, 4, 9 Su S.Y....Gu D.F. (Chin. Med. J. 2005)
    7. [Association analysis between polymorphisms of PON gene cluster with coronary heart disease in Chinese]. (PubMed id 16078734)1, 4, 9 Wang X.L....Gu D.F. (Yi Chuan Xue Bao 2005)
    8. PON1 M/L55 mutation protects high-risk patients against coronary artery disease. (PubMed id 14996478)1, 4, 9 Oliveira S.A....Annichino-Bizzacchi J.M. (Int. J. Cardiol. 2004)
    9. Human paraoxonase gene cluster polymorphisms as predictors of coronary heart disease risk in the prospective Northwick Park Heart Study II. (PubMed id 14636952)1, 4, 9 Robertson K.S....Humphries S.E. (Biochim. Biophys. Acta 2003)
    10. Extensive association analysis between polymorphisms of PON gene cluster with coronary heart disease in Chinese Han population. (PubMed id 12588779)1, 4, 9 Wang X....Gu D. (Arterioscler. Thromb. Vasc. Biol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5446 HGNC: 9206 AceView: PON3 Ensembl:ENSG00000105852 euGenes: HUgn5446
    ECgene: PON3 Kegg: 5446 H-InvDB: PON3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PON3 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/pon3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PON3 gene:
    Search GeneIP for patents involving PON3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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