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Set Analyses:

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PON3 Gene

protein-coding GIFtS: 63
GCID: GC07M094989

Paraoxonase 3

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Paraoxonase 3¹ ²		EC 3.1.1.2³
Arylesterase 3¹ ²		EC 3.1.1.81³
paraoxanase-3²		EC 3.1.8.1³
Serum Paraoxonase/Lactonase 3²

External Ids:	HGNC: 9206¹	Entrez Gene: 5446²	Ensembl: ENSG00000105852⁷	OMIM: 602720⁵	UniProtKB: Q15166³

Export aliases for PON3 gene to outside databases

Previous GC identifers: GC07M093524 GC07M094587 GC07M094601 GC07M094633 GC07M094827 GC07M089596

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PON3 Gene:

This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family

members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL).

The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a

function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced

variants which encode different protein isoforms have been described; however, only one has been fully

characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for PON3 Gene:

PON3 (paraoxonase 3) is a protein-coding gene. Diseases associated with PON3 include atherosclerosis, and amyotrophic lateral sclerosis. GO annotations related to this gene include aryldialkylphosphatase activity and protein homodimerization activity. An important paralog of this gene is PON1.

UniProtKB/Swiss-Prot: PON3_HUMAN, Q15166

Function: Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly

hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member

ring lactones with aliphatic substituents but not simple lactones or those with polar substituents

Gene Wiki entry for PON3 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000007.14 NC_018918.2 NT_007933.16

Regulatory elements:

Regulatory transcription factor binding sites in the PON3 gene promoter:
c-Fos AP-1 JunB FosB Fra-1 POU6F1 (c2) LCR-F1 GATA-1 JunD c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PON3 promoter sequence

Search Chromatin IP Primers for PON3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PON3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.3 Ensembl cytogenetic band: 7q21.3 HGNC cytogenetic band: 7q21.3

PON3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PON3 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M094989: view genomic region (about GC identifiers)

Start:	94,989,184 bp from pter	End:	95,025,687 bp from pter
Size:	36,504 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 94,318,186-94,354,692

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PON3_HUMAN, Q15166 (See protein sequence)

Recommended Name: Serum paraoxonase/lactonase 3

Size: 354 amino acids; 39607 Da

Cofactor: Binds 2 calcium ions per subunit (By similarity)

Subunit: Homodimer

Secondary accessions: A4D1H8 O75855 O76060 Q6IRU9 Q8IX97 Q9BZH9

Explore the universe of human proteins at neXtProt for PON3: NX_Q15166

Explore proteomics data for PON3 at MOPED

Post-translational modifications:

The signal sequence is not cleaved (By similarity)¹

Glycosylation² at Asn29, Asn269, Asn323

Modification sites at PhosphoSitePlus

See PON3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_000931.1

ENSEMBL proteins:

ENSP00000265627 ENSP00000413276 ENSP00000403850 ENSP00000393174 ENSP00000390253

ENSP00000391072

PON3 Human Recombinant Protein Products:

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	LSBio Antibodies in human, mouse, rat for PON3

PON3 Assay Products:

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	Cloud-Clone Corp. ELISAs for PON3 Cloud-Clone Corp. CLIAs for PON3

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

PON: Paraoxonases

3 InterPro protein domains:

IPR008364 Paraoxonase2

IPR002640 Arylesterase

IPR011042 6-blade_b-propeller_TolB-like

Graphical View of Domain Structure for InterPro Entry Q15166

ProtoNet protein and cluster: Q15166

1 Blocks protein domain: IPB002640 Arylesterase

UniProtKB/Swiss-Prot: PON3_HUMAN, Q15166

Similarity: Belongs to the paraoxonase family

PON3 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: PON3_HUMAN, Q15166

Function: Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly

hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member

ring lactones with aliphatic substituents but not simple lactones or those with polar substituents

Catalytic activity: A phenyl acetate + H(2)O = a phenol + acetate

Catalytic activity: An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol

Catalytic activity: An N-acyl-L-homoserine lactone + H(2)O = an N-acyl-L-homoserine

Genatlas biochemistry entry for PON3:

paraoxonase-like sequence 2(PON3)

Enzyme Numbers (IUBMB): EC 3.1.1.2¹ EC 3.1.1.81¹ EC 3.1.8.1¹

Gene Ontology (GO): Selected molecular function terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004063	aryldialkylphosphatase activity	IEA	--
GO:0004064	arylesterase activity	NAS	8661009
GO:0016844	strictosidine synthase activity	--	--
GO:0018733	3,4-dihydrocoumarin hydrolase activity	IEA	--
GO:0042803	protein homodimerization activity	IDA	15772423

PON3 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for PON3:

Increased gamma-H2AX phosphory

Increased number of cells in m

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pon3):

cellular

embryogenesis

growth/size/body

homeostasis/metabolism

mortality/aging

PON3 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Pon3^tm1Lus for PON3

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PON3

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PON3

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PON3

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PON3

miRNA Products:		miRTarBase miRNAs that target PON3: hsa-mir-335-5p (MIRT017621)

		Block miRNA regulation of human, mouse, rat PON3 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate PON3
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for PON3
		Predesigned siRNA for gene silencing in human, mouse, rat PON3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PON3

Clone Products:		OriGene clones in human, mouse for PON3 (see all 6) OriGene ORF clones in mouse, rat for PON3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Sino Biological Human cDNA Clone for PON3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PON3
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PON3
		Browse ESI BIO Cell Lines and PureStem Progenitors for PON3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PON3

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

PON3_HUMAN, Q15166: Secreted, extracellular space (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
endoplasmic reticulum	2
nucleus	2

About this image

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	--	--
GO:0005615	extracellular space	IEA	--
GO:0043231	intracellular membrane-bounded organelle	IEA	--
GO:0070062	extracellular vesicular exosome	IDA	19199708

PON3 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for PON3 About

See pathways by source

SuperPath

Contained pathways About

Metabolism

Metabolic pathways

0.38

Phase I, non P450

Phase I, non P450

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for PON3

Phase I, non P450

1 Kegg Pathway (Kegg details for PON3):

Metabolic pathways

PON3 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Array including PON3:

Drug Metabolism in human mouse rat

Interactions:

GeneGlobe Interaction Network for PON3

Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009058	biosynthetic process	--	--
GO:0009605	response to external stimulus	NAS	8661009
GO:0010124	phenylacetate catabolic process	IEA	--
GO:0019439	aromatic compound catabolic process	IDA	15772423
GO:0046226	coumarin catabolic process	IEA	--

PON3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for PON3

Selected HMDB Compounds for PON3 (see all 19) About this table

Compound	Synonyms	CAS #	PubMed Ids
1-Butanol	1-Butanol (see all 10)	71-36-3	--
1-Hexanol	1-Hexyl alcohol (see all 30)	111-27-3	--
1-Pentanol	1-Pentol (see all 34)	71-41-0	--
4-Nitrophenol	1-Hydroxy-4-nitrobenzene (see all 8)	100-02-7	--
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Acetic acid	Acetate (see all 12)	64-19-7	--
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Diethylthiophosphate	DETP (see all 6)	5871-17-0	--
Ethanol	1-Hydroxyethane (see all 57)	64-17-5	--

2 DrugBank Compounds for PON3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Edetic Acid	CaEDTA (see all 8)	62-33-9	enzyme	inhibitor	17292339
Lovastatin	6 alpha-Methylcompactin (see all 4)	75330-75-5	enzyme	substrate	10931838

4 Novoseek inferred chemical compound relationships for PON3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
phenylacetate	83.7	1	11304470 (1)
paraoxon	76.9	1	11304470 (1)
lovastatin	36.5	1	15772423 (1)
cholesterol	33.1	2	18585453 (2)

PON3 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for PON3 gene:

NM_000940.2

Unigene Cluster for PON3:

Paraoxonase 3

Hs.440967 [show with all ESTs]

Unigene Representative Sequence: CD014095

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000265627(uc003unt.3) ENST00000427422 ENST00000451904 ENST00000418617

ENST00000442770 ENST00000456855 ENST00000492800 ENST00000460248 ENST00000482624(uc011kii.2)

ENST00000475439

miRNA Products:		Block miRNA regulation of human, mouse, rat PON3 using miScript Target Protectors
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		Predesigned siRNA for gene silencing in human, mouse, rat PON3

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		GenScript: all cDNA clones in your preferred vector: PON3 (NM_000940)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PON3
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		Pre-validated RT² qPCR Primer Assay in human, mouse, rat PON3
		QuantiTect SYBR Green Assays in human, mouse, rat PON3
		QuantiFast Probe-based Assays in human, mouse, rat PON3

Additional mRNA sequence:

AF320003.1 AF329433.1 AK304282.1 BC020908.1 BC070374.1 L48516.1

18 DOTS entries:

DT.313453 DT.92425664 DT.92425663 DT.101983699 DT.40121264 DT.101983703 DT.92425666 DT.100731698

DT.100738978 DT.100762569 DT.101983700 DT.101983701 DT.40121265 DT.92425659 DT.92425662 DT.100653477

DT.101983702 DT.75151092

Selected AceView cDNA sequences (see all 80):

BF513914 AV653103 AF329433 AI074616 AV660394 CD014102 AI674127 CD014096

AV660412 AI247797 AA973222 CB160649 BF059348 CD014100 CD014099 AV658512

BE504490 AA494323 AI866606 AI033844 CD014095 NM_000940 T81888 BU071352

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PON3 expression in normal human tissues (normalized intensities) PON3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGAAAATTCT

About this image

PON3 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


Skeletal Muscle (Muscoskeletal System) fully expand to see all 2 entries
Myoblasts Mandibular Arch Muscles

Testis (Reproductive System)
Sertoli cells Seminiferous Tubules

Liver (Hepatobiliary System)
Hepatocytes Liver Lobule

Blood (Hematopoietic System)
Hematopoietic Stem Cells Hematopoietic Bone Marrow

PON3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

PON3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.440967

Pathway & Disease-focused RT² Profiler PCR Array including PON3:

Drug Metabolism in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for PON3 OriGene qSTAR qPCR primer pairs in human, mouse for PON3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat PON3
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		QuantiFast Probe-based Assays in human, mouse, rat PON3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PON3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for PON3 gene from Selected species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pon3^{1 , 5}	paraoxonase 3^{1, 5}	83.71(n)¹ 81.36(a)¹		6 (1.99 cM)⁵ 269823¹ NM_173006.1¹ NP_766594.1¹ 5220852⁵
chicken (Gallus gallus)	Aves	PON2⁶	serum paraoxonase/arylesterase 2 precursor	65(a)	1 → many	2(23977867-23996726)
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	55(a)	1 → many	6(22503357-22522885)
zebrafish (Danio rerio)	Actinopterygii	zgc:174637⁶ pon2⁶ (see all 4)	paraoxonase 2 (see all 4)	50(a) 50(a) (see all 4)	many ↔ many many ↔ many (see all 4)	16(26896251-26900819) ENSDARG00000097789 16(26909176-26912212) ENSDARG00000016856
worm (Caenorhabditis elegans)	Secernentea	poml-2¹	poml-2	44.38(n) 30.65(a)		171999 NM_058905.4 NP_491306.1

ENSEMBL Gene Tree for PON3 (if available)
TreeFam Gene Tree for PON3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PON3 gene

PON1² PON2²

2 SIMAP similar genes for PON3 using alignment to 5 protein entries: PON3_HUMAN (see all proteins):

PON2 PON1

PON3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11388951^1,2	C	--	94998126(+)	`AAAAA-/AGAAAG`	1	--	int¹ trp³		1		NA	2
rs34582490^1,2	C	--	95008390(+)	`AAAAAA/-GCAGG`	1	--	int¹		1		NA	2
rs17878661^1,2	C,F	--	95020175(-)	`GTGTAG/-GTGAC`	1	--	int¹		2		NS	88
rs11378129^1,2	C	--	95023616(+)	`AGAAAG/-GAAGC`	1	--	int¹ trp³		2		NA CSA	6
rs113996539^1,2	F	--	98295383(+)	`GTGTCG/AGTACC`	1	--	ds500¹		1		WA	118
rs192956034^1,2		--	98295549(+)	`GGACTA/GTAGGA`	1	--	ds500¹		0	--	--	--	--
rs17882643^1,2	C,F	--	98295593(-)	`TAACTG/AGGTCC`	1	--	ds500¹		2		NS	82
rs184026909^1,2		--	98295688(+)	`AGATCC/TGTAAA`	1	--	ds500¹		0	--	--	--	--
rs17885558^1,2	C,F	--	98295869(-)	`GTCTAC/TATATT`	1	--	ut3¹		10		NS NA WA CSA EA EU	1225
rs145880790^1,2	C	--	98295901(+)	`TCTAGA/GGTCTA`	1	--	ut3¹		1		EU	1293

HapMap Linkage Disequilibrium report for PON3 (94989184 - 95025687 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for PON3: About this table

Variant ID	Type	Subtype	PubMed ID
esv2660407	CNV	Deletion	23128226
nsv888740	CNV	Gain	21882294
nsv888743	CNV	Gain	21882294

Human Gene Mutation Database (HGMD): PON3

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing PON3

DNA2.0 Custom Variant and Variant Library Synthesis for PON3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 602720 OMIM disorders: --

16 diseases for PON3: About MalaCards

atherosclerosis amyotrophic lateral sclerosis coronary heart disease vascular dementia

acute myocardial infarction lateral sclerosis cataract coronary artery disease

myocardial infarction dementia obesity alzheimer's disease

systemic lupus erythematosus lupus erythematosus colorectal cancer hepatocellular carcinoma

1 disease from the University of Copenhagen DISEASES database for PON3:

Atherosclerosis

PON3 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

4 Novoseek inferred disease relationships for PON3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
atherosclerosis	60	13	17446441 (3), 17379834 (2), 11304457 (1), 19359600 (1) (see all 9)
coronary heart disease	43.4	2	11803456 (1), 16120573 (1)
cardiovascular diseases	37.3	2	11803456 (1), 19082953 (1)
stroke	0	1	16239632 (1)

Genetic Association Database (GAD): PON3
Human Genome Epidemiology (HuGE) Navigator: PON3 (36 documents)

Export disorders for PON3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PON3 gene, integrated from 10 sources (see all 102):
(articles sorted by number of sources associating them with PON3)

Utopia: connect your pdf to the dynamic
world of online information

The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. (PubMed id 8661009)^{1, 2, 3, 9} Primo-Parmo S.L.... La Du B.N. (Genomics 1996)
Genetic variation in the paraoxonase-3 (PON3) gene is associated with serum PON1 activity. (PubMed id 17900266)^{1, 4, 9} Sanghera D.K....Kamboh M.I. (Ann. Hum. Genet. 2008)
Identification of paraoxonase 3 gene (PON3) missense mutations in a population of southern Italy. (PubMed id 14757195)^{1, 4, 9} Campo S....Saitta A. (Mutat. Res. 2004)
Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. (PubMed id 15772423)^{1, 2, 9} Draganov D.I....La Du B.N. (J. Lipid Res. 2005)
Paraoxonase gene polymorphisms and haplotype analysis in a stroke population. (PubMed id 16551349)^{1, 4, 9} Pasdar A....MacLeod M.J. (BMC Med. Genet. 2006)
Paraoxonase gene cluster variations associated with coronary heart disease in Chinese Han women. (PubMed id 16117861)^{1, 4, 9} Su S.Y....Gu D.F. (Chin. Med. J. 2005)
[Association analysis between polymorphisms of PON gene cluster with coronary heart disease in Chinese]. (PubMed id 16078734)^{1, 4, 9} Wang X.L....Gu D.F. (Yi Chuan Xue Bao 2005)
PON1 M/L55 mutation protects high-risk patients against coronary artery disease. (PubMed id 14996478)^{1, 4, 9} Oliveira S.A....Annichino-Bizzacchi J.M. (Int. J. Cardiol. 2004)
Human paraoxonase gene cluster polymorphisms as predictors of coronary heart disease risk in the prospective Northwick Park Heart Study II. (PubMed id 14636952)^{1, 4, 9} Robertson K.S....Humphries S.E. (Biochim. Biophys. Acta 2003)
Extensive association analysis between polymorphisms of PON gene cluster with coronary heart disease in Chinese Han population. (PubMed id 12588779)^{1, 4, 9} Wang X....Gu D. (Arterioscler. Thromb. Vasc. Biol. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5446	HGNC: 9206	AceView: PON3	Ensembl:ENSG00000105852	euGenes: HUgn5446
ECgene: PON3	Kegg: 5446	H-InvDB: PON3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PON3	Pharmacogenomics, SNPs, Pathways
SeattleSNPs	http://pga.gs.washington.edu/data/pon3/

Intellectual Property for PON3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PON3 gene:
Search GeneIP for patents involving PON3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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