Aliases for PON3 Gene
Aliases for PON3 Gene
External Ids for PON3 Gene
- HGNC: 9206
- Entrez Gene: 5446
- Ensembl: ENSG00000105852
- OMIM: 602720
- UniProtKB: Q15166
Previous GeneCards Identifiers for PON3 Gene
- GC07M093524
- GC07M094587
- GC07M094601
- GC07M094633
- GC07M094827
- GC07M094989
- GC07M089596
Summaries for PON3 Gene
-
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for PON3 Gene
PON3 (Paraoxonase 3) is a Protein Coding gene. Diseases associated with PON3 include Amyotrophic Lateral Sclerosis 1 and Coronary Heart Disease 1. Among its related pathways are Metabolism and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and strictosidine synthase activity. An important paralog of this gene is PON2.
UniProtKB/Swiss-Prot for PON3 Gene
-
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
Additional gene information for PON3 Gene
- Monarch Initiative
- Search for PON3 at DataMed
- Search for PON3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PON3 Gene
Genomics for PON3 Gene
GeneHancer (GH) Regulatory Elements for PON3 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH07I095395 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE | 557.5 | -0.5 | -514 | 2.3 | PKNOX1 RB1 ARID4B SIN3A DMAP1 ZNF48 RAD21 RARA YY1 ATF7 | PON3 ASB4 ENSG00000273138 | |
GH07I095429 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE | 16.4 | -36.4 | -36421 | 6.8 | HDGF SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 | PON2 PON3 ASB4 PON1 ENSG00000233942 ENSG00000273138 | |
GH07I095439 | Enhancer | 1.1 | FANTOM5 ENCODE | 13.2 | -45.2 | -45240 | 4.2 | FOXA2 MLX ZFP64 ARID4B DMAP1 ETS1 YY1 TCF12 ATF7 RXRA | PON1 PON3 PON2 PDK4 ASB4 | |
GH07I095330 | Enhancer | 0.8 | Ensembl ENCODE | 15.6 | +65.6 | 65615 | 1.4 | SRF PKNOX1 IRF2 TRIM22 CEBPB NBN MLLT1 HNF4A ATF7 IKZF2 | PON3 PON1 ENSG00000237160 | |
GH07I095544 | Enhancer | 1 | Ensembl ENCODE | 10.6 | -150.2 | -150161 | 4.1 | RAD21 RFX5 YY1 GTF3C2 ZNF335 ZNF366 FOS SMARCA5 ZNF362 ZNF654 | ENSG00000231170 PON3 PON1 ASB4 ENSG00000279525 PDK4 |
Regulatory Element Products
Genomic Locations for PON3 Gene
- chr7:95,359,872-95,396,375
- (GRCh38/hg38)
- Size:
- 36,504 bases
- Orientation:
- Minus strand
- chr7:94,989,184-95,025,687
- (GRCh37/hg19)
Genomic View for PON3 Gene
- Cytogenetic band:
-
- 7q21.3 by Ensembl
- 7q21.3 by Entrez Gene
- 7q21.3 by HGNC


RefSeq DNA sequence for PON3 Gene
Proteins for PON3 Gene
-
Protein details for PON3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15166-PON3_HUMAN
- Recommended name:
- Serum paraoxonase/lactonase 3
- Protein Accession:
- Q15166
- A4D1H8
- O75855
- O76060
- Q6IRU9
- Q8IX97
- Q9BZH9
Protein attributes for PON3 Gene
- Size:
- 354 amino acids
- Molecular mass:
- 39607 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Quaternary structure:
-
- Homodimer.
Protein Expression for PON3 Gene
Post-translational modifications for PON3 Gene
- The signal sequence is not cleaved.
- Glycosylation at Asn29, Asn269, and Asn323
Other Protein References for PON3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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-
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-
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-
Abcam assays for PON3
No data available for DME Specific Peptides for PON3 Gene
Domains & Families for PON3 Gene
Gene Families for PON3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Candidate cardiovascular disease genes
- Enzymes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for PON3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PON3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q15166- Family:
-
- Belongs to the paraoxonase family.
Function for PON3 Gene
Molecular function for PON3 Gene
- GENATLAS Biochemistry:
- paraoxonase-like sequence 2(PON3)
- UniProtKB/Swiss-Prot CatalyticActivity:
- A phenyl acetate + H(2)O = a phenol + acetate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol.
- UniProtKB/Swiss-Prot CatalyticActivity:
- An N-acyl-L-homoserine lactone + H(2)O = an N-acyl-L-homoserine.
- UniProtKB/Swiss-Prot Function:
- Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
Enzyme Numbers (IUBMB) for PON3 Gene
Phenotypes From GWAS Catalog for PON3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004063 | aryldialkylphosphatase activity | IEA | -- |
GO:0004064 | arylesterase activity | NAS,IEA | 8661009 |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0018733 | 3,4-dihydrocoumarin hydrolase activity | IEA | -- |
GO:0042803 | protein homodimerization activity | IDA | 15772423 |
Phenotypes for PON3 Gene
- MGI mutant phenotypes for PON3:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for PON3:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased hepcidin::fluc mRNA expression
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased viability after Maraba virus infection
- Decreased IL-8 secretion
- Weakly decreased NFAT1-GFP nuclear translocation
- Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
Animal Model Products
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-
-
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-
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-
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miRNA for PON3 Gene
- miRTarBase miRNAs that target PON3
miRNA Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PON3 gene related products
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-
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Cell Line Products
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Horizon Cell Lines for PON3
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No data available for Transcription Factor Targets and HOMER Transcription for PON3 Gene
Localization for PON3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PON3 Gene
- Secreted, extracellular space.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA | -- |
GO:0043231 | intracellular membrane-bounded organelle | IEA | -- |
GO:0070062 | extracellular exosome | HDA,IDA | 19199708 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PON3 Gene
Pathways & Interactions for PON3 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Arachidonic acid metabolism | ||
2 | Metabolism |
.37
|
|
3 | Phase I biotransformations, non P450 |
Pathways by source for PON3 Gene
1 BioSystems pathway for PON3 Gene
4 Reactome pathways for PON3 Gene
Interacting Proteins for PON3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0009605 | response to external stimulus | NAS | 8661009 |
GO:0009636 | response to toxic substance | IBA | -- |
GO:0010124 | phenylacetate catabolic process | IEA | -- |
GO:0016311 | dephosphorylation | IEA | -- |
GO:0019372 | lipoxygenase pathway | TAS | -- |
No data available for SIGNOR curated interactions for PON3 Gene
Drugs & Compounds for PON3 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Lovastatin | Approved, Investigational | Pharma | Competitive, Inhibitor, Enzyme, substrate | HMG-CoA reductase inhibitor, Potent HMG-CoA reductase inhibitor | 68 | |
Edetic Acid | Approved, Vet_approved | Pharma | Enzyme, inhibitor | 114 | ||
Hydroquinone | Approved, Investigational | Pharma | 40 | |||
Isopropyl alcohol | Approved, Investigational | Pharma | 0 | |||
Phenol | Approved, Experimental | Pharma | 52 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Paraoxon |
|
311-45-5 | ||||
1-Hexanol |
|
111-27-3 |
|
|||
1-Pentanol |
|
71-41-0 |
|
|||
4-Hydroxyphenyl acetate |
|
|
||||
ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for PON3 Gene
mRNA/cDNA for PON3 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (80) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PON3 gene related products
- orf clones - Search results for available PON3 gene related products
- Applied Biological Materials Clones for PON3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PON3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Skeletal Muscle (Muscoskeletal System)
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Brain (Nervous System)
mRNA differential expression in normal tissues according to GTEx for PON3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PON3 Gene
NURSA nuclear receptor signaling pathways regulating expression of PON3 Gene:
PON3SOURCE GeneReport for Unigene cluster for PON3 Gene:
Hs.440967Evidence on tissue expression from TISSUES for PON3 Gene
- Liver(4.7)
- Bone marrow(4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PON3 Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- digestive
- nervous
- respiratory
- skeletal muscle
- skeleton
- brain
- cerebellum
- cranial nerve
- ear
- epiglottis
- face
- head
- jaw
- larynx
- mandible
- maxilla
- mouth
- neck
- nose
- pharynx
- skull
- tongue
- vocal cord
- bronchus
- clavicle
- esophagus
- heart
- lung
- scapula
- trachea
- biliary tract
- liver
- stomach
- arm
- digit
- finger
- foot
- forearm
- hand
- humerus
- lower limb
- shin
- shoulder
- thigh
- toe
- upper limb
- blood vessel
- peripheral nerve
- peripheral nervous system
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for PON3
-
OriGene qPCR primer pairs and template standards for PON3
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No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PON3 Gene
Orthologs for PON3 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PON3 33 |
|
||
dog (Canis familiaris) |
Mammalia | PON3 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | PON3 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Pon3 33 |
|
||
mouse (Mus musculus) |
Mammalia | Pon3 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | PON3 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | PON2 34 |
|
OneToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
zebrafish (Danio rerio) |
Actinopterygii | pon2 34 |
|
ManyToMany | |
zgc:174637 34 34 |
|
ManyToMany | |||
pon1 34 |
|
ManyToMany | |||
worm (Caenorhabditis elegans) |
Secernentea | poml-2 33 34 |
|
||
poml-3 34 |
|
ManyToMany | |||
poml-4 34 |
|
ManyToMany | |||
mec-6 34 |
|
ManyToMany |
- Species where no ortholog for PON3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for PON3 Gene
(2) SIMAP similar genes for PON3 Gene using alignment to 5 proteins:
Variants for PON3 Gene
SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs201544566 | uncertain-significance, not specified | 95,364,062(-) | C/T | coding_sequence_variant, missense_variant | |
rs1000308314 | -- | 95,377,881(-) | A/G | intron_variant | |
rs1000361627 | -- | 95,377,645(-) | T/C/G | intron_variant | |
rs1000452747 | -- | 95,388,406(-) | TT/T | intron_variant | |
rs1000471986 | -- | 95,384,677(-) | G/A | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2660407 | CNV | deletion | 23128226 |
esv3614193 | CNV | loss | 21293372 |
nsv1023193 | CNV | gain | 25217958 |
nsv607862 | CNV | loss | 21841781 |
Additional Variant Information for PON3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PON3 Gene
Disorders for PON3 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
amyotrophic lateral sclerosis 1 |
|
|
coronary heart disease 1 |
|
Additional Disease Information for PON3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PON3 Gene
Publications for PON3 Gene
- The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. (PMID: 8661009) Primo-Parmo SL … La Du BN (Genomics 1996) 2 3 4 22 58
- Genetic variation in the paraoxonase-3 (PON3) gene is associated with serum PON1 activity. (PMID: 17900266) Sanghera DK … Kamboh MI (Annals of human genetics 2008) 3 22 44 58
- Paraoxonase gene polymorphisms and haplotype analysis in a stroke population. (PMID: 16551349) Pasdar A … MacLeod MJ (BMC medical genetics 2006) 3 22 44 58
- Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. (PMID: 15772423) Draganov DI … La Du BN (Journal of lipid research 2005) 3 4 22 58
- [Association analysis between polymorphisms of PON gene cluster with coronary heart disease in Chinese]. (PMID: 16078734) Wang XL … Gu DF (Yi chuan xue bao = Acta genetica Sinica 2005) 3 22 44 58
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PON3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 72 available PON3 Antibodies ranked by validation data
- Compare Top PON3 Antibodies
- antibodies-online: Search results for 19 available PON3 Elisa Kits ranked by validation data
- Compare Top PON3 Elisa Kits
- antibodies-online: Search results for 6 available PON3 Proteins ranked by validation data
- Compare Top PON3 Proteins
- Search GeneTex for Antibodies for PON3
- Search GeneTex for Proteins for PON3
- ViGene Biosciences adenoviral particle packaged cDNA for PON3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PON3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PON3 gene
- Search ViGene Biosciences for PON3
- Santa Cruz Biotechnology (SCBT) Antibodies for PON3
- Search Santa Cruz Biotechnology (SCBT) for PON3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PON3
- Horizon Cell Lines for PON3
- genomics-online: cdna clones - Search results for available PON3 gene related products
- orf clones - Search results for available PON3 gene related products
- genomics-online: gRNA clones - Search results for available PON3 gene related products
- genomics-online: primer clones - Search results for available PON3 gene related products
- genomics-online: shRNA clones - Search results for available PON3 gene related products
Sources for PON3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew