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PON3 Gene(Protein Coding)

Paraoxonase 3

GCID:
GC07M095359
GIFtS:
63
Genes Participants
UDN Logo

Aliases for PON3 Gene

Aliases for PON3 Gene

  • Paraoxonase 3 2 3 5
  • Arylesterase 3 2 3
  • Serum Paraoxonase/Lactonase 3 3
  • Paraoxanase-3 3
  • EC 3.1.1.81 4
  • EC 3.1.1.2 4
  • EC 3.1.8.1 4

External Ids for PON3 Gene

Previous GeneCards Identifiers for PON3 Gene

  • GC07M093524
  • GC07M094587
  • GC07M094601
  • GC07M094633
  • GC07M094827
  • GC07M094989
  • GC07M089596

Summaries for PON3 Gene

Entrez Gene Summary for PON3 Gene

  • This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for PON3 Gene

PON3 (Paraoxonase 3) is a Protein Coding gene. Diseases associated with PON3 include Amyotrophic Lateral Sclerosis 1 and Atherosclerosis. Among its related pathways are Arachidonic acid metabolism and Phase I biotransformations, non P450. GO annotations related to this gene include protein homodimerization activity and strictosidine synthase activity. An important paralog of this gene is PON2.

UniProtKB/Swiss-Prot for PON3 Gene

  • Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.

Gene Wiki entry for PON3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PON3 Gene

Genomics for PON3 Gene

Products:

  1. Regulatory Element

Regulatory Elements for PON3 Gene

Enhancers for PON3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G095429 1.4 Ensembl ENCODE 16.4 -36.4 -36421 6.8 HDGF FOXA2 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 PON3 PON2 ASB4 PON1 ENSG00000233942 ENSG00000273138
GH07G095439 1.2 FANTOM5 ENCODE 13.2 -45.2 -45240 4.2 HNRNPUL1 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 YY1 TCF12 SP5 PON1 PON3 PON2 PDK4 ASB4
GH07G095330 0.9 Ensembl ENCODE 15.6 +65.6 65616 1.4 SRF PKNOX1 IRF2 TRIM22 CEBPB EP300 NBN HNF4A IRF1 RELB PON3 PON1 ENSG00000237160
GH07G095544 1.1 Ensembl ENCODE 10.6 -150.2 -150161 4.1 RAD21 YY1 GTF3C2 ZNF366 FOS ZNF654 ZNF362 CEBPB REST NR2F2 ENSG00000231170 PON3 RPS3AP25 PON1 ASB4 ENSG00000279525 PDK4
GH07G095246 1.1 Ensembl ENCODE 10.4 +149.3 149339 0.5 PKNOX1 FEZF1 ZNF2 RAD21 ZNF366 RELB ZNF391 DEK ZNF263 ZNF654 PON1 PON3 RNU4-16P GC07M095243 GC07P095276
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PON3 on UCSC Golden Path with GeneCards custom track

Promoters for PON3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215353 -225 1200 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF143 KLF13 MXD4

Transcription factor binding sites by QIAGEN in the PON3 gene promoter:

Genomic Location for PON3 Gene

Chromosome:
7
Start:
95,359,872 bp from pter
End:
95,396,375 bp from pter
Size:
36,504 bases
Orientation:
Minus strand

Genomic View for PON3 Gene

Genes around PON3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PON3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PON3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PON3 Gene

Proteins for PON3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PON3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15166-PON3_HUMAN
    Recommended name:
    Serum paraoxonase/lactonase 3
    Protein Accession:
    Q15166
    Secondary Accessions:
    • A4D1H8
    • O75855
    • O76060
    • Q6IRU9
    • Q8IX97
    • Q9BZH9

    Protein attributes for PON3 Gene

    Size:
    354 amino acids
    Molecular mass:
    39607 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homodimer.

neXtProt entry for PON3 Gene

Protein Expression for PON3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PON3 Gene

  • The signal sequence is not cleaved.
  • Glycosylation at posLast=2929, Asn269, and posLast=323323
  • Modification sites at PhosphoSitePlus

Other Protein References for PON3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for PON3
  • Santa Cruz Biotechnology (SCBT) Antibodies for PON3

Assay Products

  • Cloud-Clone Corp. Assay Kits for PON3
  • Abcam assays for PON3

No data available for DME Specific Peptides for PON3 Gene

Domains & Families for PON3 Gene

Gene Families for PON3 Gene

HGNC:

Protein Domains for PON3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PON3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15166

UniProtKB/Swiss-Prot:

PON3_HUMAN :
  • Belongs to the paraoxonase family.
Family:
  • Belongs to the paraoxonase family.
genes like me logo Genes that share domains with PON3: view

Function for PON3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for PON3 Gene

GENATLAS Biochemistry:
paraoxonase-like sequence 2(PON3)
UniProtKB/Swiss-Prot CatalyticActivity:
A phenyl acetate + H(2)O = a phenol + acetate.
UniProtKB/Swiss-Prot CatalyticActivity:
An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol.
UniProtKB/Swiss-Prot CatalyticActivity:
An N-acyl-L-homoserine lactone + H(2)O = an N-acyl-L-homoserine.
UniProtKB/Swiss-Prot Function:
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.

Enzyme Numbers (IUBMB) for PON3 Gene

Gene Ontology (GO) - Molecular Function for PON3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004063 aryldialkylphosphatase activity IEA --
GO:0004064 arylesterase activity NAS,IEA 8661009
GO:0016787 hydrolase activity IEA --
GO:0018733 3,4-dihydrocoumarin hydrolase activity IEA --
GO:0042803 protein homodimerization activity IDA 15772423
genes like me logo Genes that share ontologies with PON3: view
genes like me logo Genes that share phenotypes with PON3: view

Human Phenotype Ontology for PON3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PON3 Gene

MGI Knock Outs for PON3:

Animal Model Products

  • Taconic Biosciences Mouse Models for PON3

CRISPR Products

miRNA for PON3 Gene

miRTarBase miRNAs that target PON3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PON3

No data available for Transcription Factor Targets and HOMER Transcription for PON3 Gene

Localization for PON3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PON3 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PON3 gene
Compartment Confidence
extracellular 5
nucleus 2
endoplasmic reticulum 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PON3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IBA --
GO:0043231 intracellular membrane-bounded organelle IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with PON3: view

Pathways & Interactions for PON3 Gene

genes like me logo Genes that share pathways with PON3: view

Pathways by source for PON3 Gene

1 BioSystems pathway for PON3 Gene
1 KEGG pathway for PON3 Gene

Interacting Proteins for PON3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000265627%0d%0a9606.ENSP00000222572%0d%0a9606.ENSP00000222381%0d%0a
Selected Interacting proteins: Q15166-PON3_HUMAN ENSP00000265627 for PON3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for PON3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009605 response to external stimulus NAS 8661009
GO:0009636 response to toxic substance IBA --
GO:0010124 phenylacetate catabolic process IEA --
GO:0016311 dephosphorylation IEA --
GO:0019372 lipoxygenase pathway TAS --
genes like me logo Genes that share ontologies with PON3: view

No data available for SIGNOR curated interactions for PON3 Gene

Drugs & Compounds for PON3 Gene

Products:

  1. Drug

(12) Drugs for PON3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lovastatin Approved, Investigational Pharma Competitive, Inhibitor, Enzyme, substrate HMG-CoA reductase inhibitor, Potent HMG-CoA reductase inhibitor 63
Edetic Acid Approved, Vet_approved Pharma Enzyme, inhibitor 99
Hydroquinone Approved Pharma 39
Isopropyl alcohol Approved Pharma 0
Phenol Approved, Experimental Pharma 49

(13) Additional Compounds for PON3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Paraoxon
  • O,O-Diethyl-O-p-nitrophenylphosphoric acid
 311-45-5
1-Butanol
  • 1-Butanol
  • 1-Butyl alcohol
  • Butanol
  • Butyl alcohol
  • Butyl hydroxide
 71-36-3
1-Hexanol
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
 111-27-3
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
 71-41-0
4-Hydroxyphenyl acetate
genes like me logo Genes that share compounds with PON3: view

Transcripts for PON3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for PON3 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(80) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PON3 Gene

Paraoxonase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PON3

Alternative Splicing Database (ASD) splice patterns (SP) for PON3 Gene

No ASD Table

Relevant External Links for PON3 Gene

GeneLoc Exon Structure for
PON3
ECgene alternative splicing isoforms for
PON3

Expression for PON3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PON3 Gene

mRNA expression in normal human tissues for PON3 Gene
mRNA expression by BioGPS for PON3 GenemRNA expression by GTEx for PON3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PON3 Gene

This gene is overexpressed in Liver (x32.4).

Protein differential expression in normal tissues from HIPED for PON3 Gene

This gene is overexpressed in Liver (28.0) and Plasma (18.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PON3 Gene



NURSA nuclear receptor signaling pathways regulating expression of PON3 Gene:

PON3

SOURCE GeneReport for Unigene cluster for PON3 Gene:

Hs.440967

Evidence on tissue expression from TISSUES for PON3 Gene

  • Liver(4.7)
  • Bone marrow(4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PON3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • epiglottis
  • face
  • head
  • jaw
  • larynx
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • pharynx
  • skull
  • tongue
  • vocal cord
Thorax:
  • bronchus
  • clavicle
  • esophagus
  • heart
  • lung
  • scapula
  • trachea
Abdomen:
  • biliary tract
  • liver
  • stomach
Limb:
  • arm
  • digit
  • finger
  • foot
  • forearm
  • hand
  • humerus
  • lower limb
  • shin
  • shoulder
  • thigh
  • toe
  • upper limb
General:
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • spinal cord
genes like me logo Genes that share expression patterns with PON3: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PON3 Gene

Orthologs for PON3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PON3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia PON3 34
  • 99.91 (n)
dog
(Canis familiaris)
 Mammalia PON3 34 35
  • 86.44 (n)
cow
(Bos Taurus)
 Mammalia PON3 35 34
  • 86.35 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Pon3 34
  • 84.37 (n)
mouse
(Mus musculus)
 Mammalia Pon3 16 35 34
  • 83.71 (n)
oppossum
(Monodelphis domestica)
 Mammalia PON3 35
  • 52 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves PON2 35
  • 65 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 55 (a)
 OneToMany
zebrafish
(Danio rerio)
 Actinopterygii zgc:174637 35 35
  • 50 (a)
 ManyToMany
pon2 35
  • 50 (a)
 ManyToMany
pon1 35
  • 49 (a)
 ManyToMany
worm
(Caenorhabditis elegans)
 Secernentea poml-2 34 35
  • 44.38 (n)
poml-3 35
  • 25 (a)
 ManyToMany
poml-4 35
  • 25 (a)
 ManyToMany
mec-6 35
  • 19 (a)
 ManyToMany
Species where no ortholog for PON3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PON3 Gene

ENSEMBL:
Gene Tree for PON3 (if available)
TreeFam:
Gene Tree for PON3 (if available)

Paralogs for PON3 Gene

Paralogs for PON3 Gene

(2) SIMAP similar genes for PON3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PON3: view

Variants for PON3 Gene

Sequence variations from dbSNP and Humsavar for PON3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000308314 -- 95,377,881(+) AGCAA(A/G)GAAAC intron-variant
rs1000361627 -- 95,377,645(+) TGGAG(G/T)GGACT intron-variant
rs1000452747 -- 95,388,406(+) GCCAG(-/T)TAGAA intron-variant
rs1000471986 -- 95,384,677(+) ATGAC(A/G)ATCAT intron-variant
rs1000535084 -- 95,365,153(+) CCCTT(G/T)TAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PON3 Gene

Variant ID Type Subtype PubMed ID
esv2660407 CNV deletion 23128226
esv3614193 CNV loss 21293372
nsv1023193 CNV gain 25217958
nsv607862 CNV loss 21841781

Variation tolerance for PON3 Gene

Residual Variation Intolerance Score: 84.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PON3 Gene

Human Gene Mutation Database (HGMD)
PON3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PON3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PON3 Gene

Disorders for PON3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PON3 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
atherosclerosis
  • arteriosclerosis
- elite association - COSMIC cancer census association via MalaCards
Search PON3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PON3

Genetic Association Database (GAD)
PON3
Human Genome Epidemiology (HuGE) Navigator
PON3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PON3
genes like me logo Genes that share disorders with PON3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PON3 Gene

Publications for PON3 Gene

  1. The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. (PMID: 8661009) Primo-Parmo S.L. … La Du B.N. (Genomics 1996) 2 3 4 22 64
  2. Genetic variation in the paraoxonase-3 (PON3) gene is associated with serum PON1 activity. (PMID: 17900266) Sanghera D.K. … Kamboh M.I. (Ann. Hum. Genet. 2008) 3 22 46 64
  3. Paraoxonase gene polymorphisms and haplotype analysis in a stroke population. (PMID: 16551349) Pasdar A. … MacLeod M.J. (BMC Med. Genet. 2006) 3 22 46 64
  4. Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. (PMID: 15772423) Draganov D.I. … La Du B.N. (J. Lipid Res. 2005) 3 4 22 64
  5. [Association analysis between polymorphisms of PON gene cluster with coronary heart disease in Chinese]. (PMID: 16078734) Wang X.L. … Gu D.F. (Yi Chuan Xue Bao 2005) 3 22 46 64

Products for PON3 Gene

Sources for PON3 Gene

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