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Aliases for PON3 Gene

Aliases for PON3 Gene

  • Paraoxonase 3 2 3
  • Arylesterase 3 2 3
  • Serum Paraoxonase/Lactonase 3 3
  • Paraoxanase-3 3
  • EC 3.1.1.81 4
  • EC 3.1.1.2 4
  • EC 3.1.8.1 4

External Ids for PON3 Gene

Summaries for PON3 Gene

Entrez Gene Summary for PON3 Gene

  • This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for PON3 Gene

PON3 (Paraoxonase 3) is a Protein Coding gene. Diseases associated with PON3 include peripheral artery disease and amyotrophic lateral sclerosis 1. Among its related pathways are Metabolism and Phase I, non P450. GO annotations related to this gene include protein homodimerization activity and aryldialkylphosphatase activity. An important paralog of this gene is PON2.

UniProtKB/Swiss-Prot for PON3 Gene

  • Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.

Gene Wiki entry for PON3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PON3 Gene

Genomics for PON3 Gene

Genomic Location for PON3 Gene

Start:
95,359,872 bp from pter
End:
95,396,375 bp from pter
Size:
36,504 bases
Orientation:
Minus strand

Genomic View for PON3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PON3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PON3 Gene

Regulatory Elements for PON3 Gene

Proteins for PON3 Gene

  • Protein details for PON3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15166-PON3_HUMAN
    Recommended name:
    Serum paraoxonase/lactonase 3
    Protein Accession:
    Q15166
    Secondary Accessions:
    • A4D1H8
    • O75855
    • O76060
    • Q6IRU9
    • Q8IX97
    • Q9BZH9

    Protein attributes for PON3 Gene

    Size:
    354 amino acids
    Molecular mass:
    39607 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 2 calcium ions per subunit.;
    Quaternary structure:
    • Homodimer.

neXtProt entry for PON3 Gene

Proteomics data for PON3 Gene at MOPED

Post-translational modifications for PON3 Gene

Other Protein References for PON3 Gene

No data available for DME Specific Peptides for PON3 Gene

Domains for PON3 Gene

Gene Families for PON3 Gene

HGNC:
  • PON :Paraoxonases

Protein Domains for PON3 Gene

Suggested Antigen Peptide Sequences for PON3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15166

UniProtKB/Swiss-Prot:

PON3_HUMAN
Family:
  • Belongs to the paraoxonase family.:
    • Q15166
genes like me logo Genes that share domains with PON3: view

Function for PON3 Gene

Molecular function for PON3 Gene

GENATLAS Biochemistry: paraoxonase-like sequence 2(PON3)
UniProtKB/Swiss-Prot CatalyticActivity: A phenyl acetate + H(2)O = a phenol + acetate.
UniProtKB/Swiss-Prot CatalyticActivity: An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol.
UniProtKB/Swiss-Prot CatalyticActivity: An N-acyl-L-homoserine lactone + H(2)O = an N-acyl-L-homoserine.
UniProtKB/Swiss-Prot Function: Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.

Enzyme Numbers (IUBMB) for PON3 Gene

Gene Ontology (GO) - Molecular Function for PON3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004063 aryldialkylphosphatase activity IEA --
GO:0004064 arylesterase activity NAS 8661009
GO:0016844 strictosidine synthase activity --
GO:0018733 3,4-dihydrocoumarin hydrolase activity IEA --
GO:0042803 protein homodimerization activity IDA 15772423
genes like me logo Genes that share ontologies with PON3: view
genes like me logo Genes that share phenotypes with PON3: view

Animal Models for PON3 Gene

MGI Knock Outs for PON3:

miRNA for PON3 Gene

miRTarBase miRNAs that target PON3

No data available for Transcription Factor Targeting and HOMER Transcription for PON3 Gene

Localization for PON3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PON3 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PON3 Gene COMPARTMENTS Subcellular localization image for PON3 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
nucleus 2

Gene Ontology (GO) - Cellular Components for PON3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with PON3: view

Pathways for PON3 Gene

SuperPathways for PON3 Gene

Superpath Contained pathways
1 Metabolism
2 Phase I, non P450
genes like me logo Genes that share pathways with PON3: view

Pathways by source for PON3 Gene

1 BioSystems pathway for PON3 Gene
1 KEGG pathway for PON3 Gene

Interacting Proteins for PON3 Gene

Gene Ontology (GO) - Biological Process for PON3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0009058 biosynthetic process --
GO:0009605 response to external stimulus NAS 8661009
GO:0010124 phenylacetate catabolic process IEA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with PON3: view

Compounds for PON3 Gene

(19) HMDB Compounds for PON3 Gene

Compound Synonyms Cas Number PubMed IDs
1-Butanol
  • 1-Butanol
71-36-3
1-Hexanol
  • 1-Hexyl alcohol
111-27-3
1-Pentanol
  • 1-Pentol
71-41-0
4-Nitrophenol
  • 1-Hydroxy-4-nitrobenzene
100-02-7
Acetic acid
  • Acetate
64-19-7

(2) Drugbank Compounds for PON3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Edetic Acid
  • CaEDTA
62-33-9 enzyme inhibitor
Lovastatin
  • 6 alpha-Methylcompactin
75330-75-5 enzyme substrate

(4) Novoseek inferred chemical compound relationships for PON3 Gene

Compound -log(P) Hits PubMed IDs
phenylacetate 83.7 1
paraoxon 76.9 1
lovastatin 36.5 1
cholesterol 33.1 2
genes like me logo Genes that share compounds with PON3: view

Transcripts for PON3 Gene

Unigene Clusters for PON3 Gene

Paraoxonase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PON3 Gene

No ASD Table

Relevant External Links for PON3 Gene

GeneLoc Exon Structure for
PON3
ECgene alternative splicing isoforms for
PON3

Expression for PON3 Gene

mRNA expression in normal human tissues for PON3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PON3 Gene

This gene is overexpressed in Liver (32.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PON3 Gene

SOURCE GeneReport for Unigene cluster for PON3 Gene Hs.440967

genes like me logo Genes that share expressions with PON3: view

No data available for mRNA Expression by UniProt/SwissProt for PON3 Gene

Orthologs for PON3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PON3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PON3 35
  • 99.91 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia PON3 35
  • 86.35 (n)
  • 81.36 (a)
PON3 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PON3 35
  • 86.44 (n)
  • 81.07 (a)
PON3 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pon3 35
  • 83.71 (n)
  • 81.36 (a)
Pon3 16
Pon3 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PON3 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pon3 35
  • 84.37 (n)
  • 81.07 (a)
chicken
(Gallus gallus)
Aves PON2 36
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii pon1 36
  • 49 (a)
ManyToMany
pon2 36
  • 50 (a)
ManyToMany
zgc:174637 36
  • 50 (a)
ManyToMany
zgc:174637 36
  • 49 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea mec-6 36
  • 19 (a)
ManyToMany
poml-2 35
  • 44.38 (n)
  • 30.65 (a)
poml-2 36
  • 26 (a)
ManyToMany
poml-3 36
  • 25 (a)
ManyToMany
poml-4 36
  • 25 (a)
ManyToMany
Species with no ortholog for PON3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PON3 Gene

ENSEMBL:
Gene Tree for PON3 (if available)
TreeFam:
Gene Tree for PON3 (if available)

Paralogs for PON3 Gene

Paralogs for PON3 Gene

Selected SIMAP similar genes for PON3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PON3: view

Variants for PON3 Gene

Sequence variations from dbSNP and Humsavar for PON3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs468 -- 95,368,641(+) ATTCC(A/G)TCTCT intron-variant
rs740264 -- 95,392,491(-) TCACT(A/C)TACAA intron-variant
rs757905 -- 95,392,586(+) TGATA(C/T)CCTAT intron-variant
rs978903 -- 95,374,855(+) TTTAT(A/G)CCTCC intron-variant
rs1003504 -- 95,389,481(-) TTTTG(A/G)AATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PON3 Gene

Variant ID Type Subtype PubMed ID
nsv888740 CNV Gain 21882294
nsv888743 CNV Gain 21882294
esv2660407 CNV Deletion 23128226

Relevant External Links for PON3 Gene

HapMap Linkage Disequilibrium report
PON3
Human Gene Mutation Database (HGMD)
PON3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PON3 Gene

Disorders for PON3 Gene

(1) University of Copenhagen DISEASES for PON3 Gene

(4) Novoseek inferred disease relationships for PON3 Gene

Disease -log(P) Hits PubMed IDs
atherosclerosis 60 12
coronary heart disease 43.4 2
cardiovascular diseases 37.3 2
stroke 0 1

Relevant External Links for PON3

Genetic Association Database (GAD)
PON3
Human Genome Epidemiology (HuGE) Navigator
PON3
genes like me logo Genes that share disorders with PON3: view

No data available for UniProtKB/Swiss-Prot for PON3 Gene

Publications for PON3 Gene

  1. The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. (PMID: 8661009) Primo-Parmo S.L. … La Du B.N. (Genomics 1996) 2 3 4 23
  2. Extensive association analysis between polymorphisms of PON gene cluster with coronary heart disease in Chinese Han population. (PMID: 12588779) Wang X. … Gu D. (Arterioscler. Thromb. Vasc. Biol. 2003) 3 23 48
  3. Human paraoxonase gene cluster polymorphisms as predictors of coronary heart disease risk in the prospective Northwick Park Heart Study II. (PMID: 14636952) Robertson K.S. … Humphries S.E. (Biochim. Biophys. Acta 2003) 3 23 48
  4. Identification of paraoxonase 3 gene (PON3) missense mutations in a population of southern Italy. (PMID: 14757195) Campo S. … Saitta A. (Mutat. Res. 2004) 3 23 48
  5. PON1 M/L55 mutation protects high-risk patients against coronary artery disease. (PMID: 14996478) Oliveira S.A. … Annichino-Bizzacchi J.M. (Int. J. Cardiol. 2004) 3 23 48

Products for PON3 Gene

Sources for PON3 Gene

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