Aliases for PON3 Gene
External Ids for PON3 Gene
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for PON3 Gene
PON3 (Paraoxonase 3) is a Protein Coding gene. Diseases associated with PON3 include peripheral artery disease and amyotrophic lateral sclerosis 1. Among its related pathways are Metabolism and Phase I, non P450. GO annotations related to this gene include protein homodimerization activity and aryldialkylphosphatase activity. An important paralog of this gene is PON2.
UniProtKB/Swiss-Prot for PON3 Gene
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.