Aliases for PON3 Gene
Aliases for PON3 Gene
External Ids for PON3 Gene
- HGNC: 9206
- Entrez Gene: 5446
- Ensembl: ENSG00000105852
- OMIM: 602720
- UniProtKB: Q15166
Previous GeneCards Identifiers for PON3 Gene
- GC07M093524
- GC07M094587
- GC07M094601
- GC07M094633
- GC07M094827
- GC07M094989
- GC07M089596
Summaries for PON3 Gene
-
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for PON3 Gene
PON3 (Paraoxonase 3) is a Protein Coding gene. Diseases associated with PON3 include Amyotrophic Lateral Sclerosis 1 and Atherosclerosis. Among its related pathways are Metabolism and Phase I, non P450. GO annotations related to this gene include protein homodimerization activity and strictosidine synthase activity. An important paralog of this gene is PON2.
UniProtKB/Swiss-Prot for PON3 Gene
-
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PON3 Gene
Genomics for PON3 Gene
Regulatory Elements for PON3 Gene
Enhancers for PON3 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around PON3 on UCSC Golden Path with GeneCards custom track
Promoters for PON3 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around PON3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PON3 gene promoter:
Regulatory Element Products
Genomic Location for PON3 Gene
- Chromosome:
- 7
- Start:
- 95,359,872 bp from pter
- End:
- 95,396,375 bp from pter
- Size:
- 36,504 bases
- Orientation:
- Minus strand
Genomic View for PON3 Gene
Genes around PON3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q21.3 by Ensembl
- 7q21.3 by Entrez Gene
- 7q21.3 by HGNC
PON3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PON3 Gene
Proteins for PON3 Gene
-
Protein details for PON3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15166-PON3_HUMAN
- Recommended name:
- Serum paraoxonase/lactonase 3
- Protein Accession:
- Q15166
- A4D1H8
- O75855
- O76060
- Q6IRU9
- Q8IX97
- Q9BZH9
Protein attributes for PON3 Gene
- Size:
- 354 amino acids
- Molecular mass:
- 39607 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Quaternary structure:
-
- Homodimer.
Protein Expression for PON3 Gene
Post-translational modifications for PON3 Gene
- The signal sequence is not cleaved.
- Glycosylation at Asn 29, Asn 269, and Asn 323
- Modification sites at PhosphoSitePlus
Other Protein References for PON3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PON3 (PON3)
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- Abcam antibodies for PON3
-
Cloud-Clone Corp. Antibodies for PON3
- Invitrogen Antibodies for PON3
- antibodies-online Antibodies for PON3: See all 68
- GeneTex PON3 antibody for PON3
-
Santa Cruz Biotechnology (SCBT) Antibodies for PON3
Protein Products
-
OriGene Purified Proteins for PON3
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-
Cloud-Clone Corp. Proteins for PON3
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Assay Products
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for PON3 (PON3)
-
Cloud-Clone Corp Assay Kits for PON3
- antibodies-online Kits for PON3: See all 14
- Abcam assays for PON3
No data available for DME Specific Peptides for PON3 Gene
Domains & Families for PON3 Gene
Gene Families for PON3 Gene
- HGNC:
Protein Domains for PON3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PON3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q15166- Family:
-
- Belongs to the paraoxonase family.
Function for PON3 Gene
Molecular function for PON3 Gene
- GENATLAS Biochemistry:
- paraoxonase-like sequence 2(PON3)
- UniProtKB/Swiss-Prot CatalyticActivity:
- A phenyl acetate + H(2)O = a phenol + acetate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol.
- UniProtKB/Swiss-Prot CatalyticActivity:
- An N-acyl-L-homoserine lactone + H(2)O = an N-acyl-L-homoserine.
- UniProtKB/Swiss-Prot Function:
- Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
Enzyme Numbers (IUBMB) for PON3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004064 | arylesterase activity | IEA,NAS | 8661009 |
Phenotypes for PON3 Gene
- MGI mutant phenotypes for PON3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PON3:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased hepcidin::fluc mRNA expression
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased viability after Maraba virus infection
- Weakly decreased NFAT1-GFP nuclear translocation
- Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
Animal Model Products
-
Taconic Biosciences Mouse Models for PON3
-
ViGene Biosciences lentiviral particle packaged cDNA for PON3 gene
-
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- Search ViGene Biosciences for PON3
CRISPR Products
-
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-
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miRNA for PON3 Gene
- miRTarBase miRNAs that target PON3
miRNA Products
- Search ViGene Biosciences for PON3
Clone Products
- OriGene clones in human for PON3
- OriGene ORF clones in human,mouse,rat for PON3
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Cell Line Products
-
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-
ViGene Biosciences lentiviral particle packaged cDNA for PON3 gene
-
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Flow Cytometry Products
No data available for Transcription Factor Targets and HOMER Transcription for PON3 Gene
Localization for PON3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PON3 Gene
- Secreted, extracellular space.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
No data available for Gene Ontology (GO) - Cellular Components for PON3 Gene
Pathways & Interactions for PON3 Gene
More details on SuperPathways for PON3| Superpath | Contained pathways | |
|---|---|---|
| 1 | Metabolism | |
| 2 | Phase I, non P450 |
Pathways by source for PON3 Gene
1 BioSystems pathway for PON3 Gene
1 KEGG pathway for PON3 Gene
Interacting Proteins for PON3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008152 | metabolic process | IEA | -- |
| GO:0009605 | response to external stimulus | NAS | 8661009 |
| GO:0032929 | negative regulation of superoxide anion generation | IEA | -- |
| GO:0046395 | carboxylic acid catabolic process | IDA | 15772423 |
No data available for SIGNOR curated interactions for PON3 Gene
Drugs & Compounds for PON3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Lovastatin | Approved, Investigational | Pharma | Competitive, Inhibitor, Enzyme, substrate | HMG-CoA reductase inhibitor, Potent HMG-CoA reductase inhibitor | 59 | |
| Edetic Acid | Approved | Pharma | Enzyme, inhibitor | 84 | ||
| Phenol | Approved, Experimental | Pharma | 44 | |||
| acetic acid | Approved | Nutra | Full agonist, Agonist | 97 | ||
| Adenosine monophosphate | Approved | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Paraoxon |
|
311-45-5 | ||||
| 1-Hexanol |
|
111-27-3 |
|
|||
| 1-Pentanol |
|
71-41-0 |
|
|||
| 4-Hydroxyphenyl acetate |
|
|
|
|||
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for PON3 Gene
mRNA/cDNA for PON3 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (80) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PON3
-
Santa Cruz Biotechnology (SCBT) CRISPR for PON3
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miRNA Products
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Clone Products
- OriGene clones in human for PON3
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Flow Cytometry Products
Expression for PON3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Skeletal Muscle (Muscoskeletal System)
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Brain (Nervous System)
mRNA differential expression in normal tissues according to GTEx for PON3 Gene
This gene is overexpressed in Liver (x32.4).
This gene is overexpressed in Liver (28.0) and Plasma (18.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PON3 Gene
SOURCE GeneReport for Unigene cluster for PON3 Gene Hs.440967
Primer Products
-
OriGene qPCR primer pairs and template standards for PON3
-
OriGene qPCR primer pairs for PON3
No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PON3 Gene
Orthologs for PON3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | PON3 35 |
|
||
| PON3 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | PON3 35 |
|
||
| PON3 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Pon3 35 |
|
||
| Pon3 16 |
|
||||
| Pon3 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | PON3 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pon3 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PON3 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PON2 36 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 36 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | pon1 36 |
|
ManyToMany | |
| pon2 36 |
|
ManyToMany | |||
| zgc:174637 36 |
|
ManyToMany | |||
| zgc:174637 36 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | poml-2 35 |
|
||
| mec-6 36 |
|
ManyToMany | |||
| poml-2 36 |
|
ManyToMany | |||
| poml-3 36 |
|
ManyToMany | |||
| poml-4 36 |
|
ManyToMany |
- Species with no ortholog for PON3:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for PON3 Gene
(2) SIMAP similar genes for PON3 Gene using alignment to 5 proteins:
Variants for PON3 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs17878827 | - | 95,367,420(-) | AATTT(A/G)AGGAA | reference, missense | |
| rs17883013 | - | 95,364,022(-) | CTATG(A/C)CACCA | reference, missense | |
| rs978903 | -- | 95,374,855(+) | TTTAT(A/G)CCTCC | intron-variant | |
| rs1003504 | -- | 95,389,481(-) | TTTTG(A/G)AATGG | intron-variant | |
| rs1006522 | -- | 95,398,217(+) | AACCT(A/C/T)ACCTA | upstream-variant-2KB |
Residual Variation Intolerance Score:
84.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.18;
51.91% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PON3 Gene
- Human Gene Mutation Database (HGMD)
- PON3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PON3 Gene
Disorders for PON3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| amyotrophic lateral sclerosis 1 |
|
|
| atherosclerosis |
|
Search PON3 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for PON3
No data available for UniProtKB/Swiss-Prot and Genatlas for PON3 Gene
Publications for PON3 Gene
- The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. (PMID: 8661009) Primo-Parmo S.L. … La Du B.N. (Genomics 1996) 2 3 4 23 67
- Protective effects of transgene expressed human PON3 against CCl4-induced subacute liver injury in mice. (PMID: 19345057) Peng W. … Qin J. (Biomed. Pharmacother. 2009) 3 23
- Comparative expression analysis reveals differences in the regulation of intestinal paraoxonase family members. (PMID: 19401157) Precourt L.P. … Levy E. (Int. J. Biochem. Cell Biol. 2009) 3 23
- Genetic variation in the paraoxonase-3 (PON3) gene is associated with serum PON1 activity. (PMID: 17900266) Sanghera D.K. … Kamboh M.I. (Ann. Hum. Genet. 2008) 3 23
- Dominant role of paraoxonases in inactivation of the Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl)-L-homoserine lactone. (PMID: 18347034) Teiber J.F. … Draganov D.I. (Infect. Immun. 2008) 3 23
Products for PON3 Gene
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- antibodies-online Antibodies for PON3: See all 68
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- GeneTex PON3 antibody for PON3
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- ViGene Biosciences adenoviral particle packaged cDNA for PON3 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for PON3 gene
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Sources for PON3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
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- (136) Genetics Home Reference
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- (138) MedlinePlus
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- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon