Aliases for PON3 Gene
External Ids for PON3 Gene
Previous GeneCards Identifiers for PON3 Gene
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for PON3 Gene
PON3 (Paraoxonase 3) is a Protein Coding gene. Diseases associated with PON3 include Amyotrophic Lateral Sclerosis 1 and Coronary Heart Disease 1. Among its related pathways are Metabolism and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and strictosidine synthase activity. An important paralog of this gene is PON2.
UniProtKB/Swiss-Prot for PON3 Gene
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.