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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PON3 Gene

protein-coding GIFtS: 59
GCID: GC07M094989

paraoxonase 3

Explore 15 diseases affiliated with
PON3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Paraoxonase 3¹ ²
Paraoxanase-3¹
Serum Paraoxonase/Lactonase 3²
EC 3.1.1.2³
EC 3.1.1.81³
EC 3.1.8.1³

External Ids:	HGNC: 9206¹	Entrez Gene: 5446²	Ensembl: ENSG00000105852⁷	OMIM: 602720⁵	UniProtKB: Q15166³

Export aliases for PON3 gene to outside databases

Previous GC identifers: GC07M093524 GC07M094587 GC07M094601 GC07M094633 GC07M094827 GC07M089596

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PON3:

This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family

members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The

protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function

that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which

encode different protein isoforms have been described; however, only one has been fully characterized. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PON3_HUMAN, Q15166

Function: Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes

lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with

aliphatic substituents but not simple lactones or those with polar substituents

Gene Wiki entry for PON3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PON3 gene promoter:
c-Fos AP-1 JunB FosB Fra-1 POU6F1 (c2) LCR-F1 GATA-1 JunD c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PON3 promoter sequence

Search SABiosciences Chromatin IP Primers for PON3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PON3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.3 Ensembl cytogenetic band: 7q21.3 HGNC cytogenetic band: 7q21.3

PON3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PON3 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M094989: view genomic region (about GC identifiers)

Start:	94,989,184 bp from pter	End:	95,025,687 bp from pter
Size:	36,504 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 94,318,186-94,354,692

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PON3_HUMAN, Q15166 (See protein sequence)

Recommended Name: Serum paraoxonase/lactonase 3

Size: 354 amino acids; 39607 Da

Cofactor: Binds 2 calcium ions per subunit (By similarity)

Subunit: Homodimer

Subcellular location: Secreted, extracellular space (By similarity)

Secondary accessions: A4D1H8 O75855 O76060 Q6IRU9 Q8IX97 Q9BZH9

Explore the universe of human proteins at neXtProt for PON3: NX_Q15166

Post-translational modifications:

The signal sequence is not cleaved (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q15166

PON3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000931.1

ENSEMBL proteins:

ENSP00000265627 ENSP00000413276 ENSP00000403850 ENSP00000393174 ENSP00000390253

ENSP00000391072

Human Recombinant Protein Products for PON3:

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	Uscn Proteins for PON3

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	--
GO:0005615	extracellular space	IEA	--
GO:0005792	microsome	--	--
GO:0043231	intracellular membrane-bounded organelle	IEA	--

PON3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PON3 for domains About GeneDecksing

3 InterPro domains/families:

IPR008364 Paraoxonase2

IPR002640 Arylesterase

IPR011042 6-blade_b-propeller_TolB-like

Graphical View of Domain Structure for InterPro Entry Q15166

ProtoNet protein and cluster: Q15166

1 Blocks protein family: IPB002640 Arylesterase

UniProtKB/Swiss-Prot: PON3_HUMAN, Q15166

Similarity: Belongs to the paraoxonase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PON3_HUMAN, Q15166

Function: Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes

lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with

aliphatic substituents but not simple lactones or those with polar substituents

Catalytic activity: A phenyl acetate + H(2)O = a phenol + acetate

Catalytic activity: An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol

Catalytic activity: An N-acyl-L-homoserine lactone + H(2)O = an N-acyl-L-homoserine

Genatlas biochemistry entry for PON3:

paraoxonase-like sequence 2(PON3)

Enzyme Numbers (IUBMB): EC 3.1.1.2¹ EC 3.1.1.81¹ EC 3.1.8.1¹

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004063	aryldialkylphosphatase activity	IEA	--
GO:0004064	arylesterase activity	NAS	8661009
GO:0018733	3,4-dihydrocoumarin hydrolase activity	IEA	--
GO:0042803	protein homodimerization activity	IDA	15772423
GO:0046872	metal ion binding	IEA	--

PON3 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for PON3:

Increased gamma-H2AX phosphory

Increased number of cells in m

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pon3):

embryogenesis

growth/size

mortality/aging

PON3 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PON3

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PON3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Phase I, non P450

Phase I, non P450

1.00

Metabolism

Metabolic pathways

0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for PON3

Phase I, non P450

1 Kegg Pathway (Kegg details for PON3):

Metabolic pathways

PON3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PON3

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009605	response to external stimulus	NAS	8661009
GO:0010124	phenylacetate catabolic process	IEA	--
GO:0019439	aromatic compound catabolic process	IDA	15772423
GO:0046226	coumarin catabolic process	IEA	--
GO:0046395	carboxylic acid catabolic process	IDA	15772423

PON3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PON3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PON3

10/19 HMDB Compounds for PON3 (see all 19) About this table

Compound	Synonyms	CAS #	PubMed Ids
1-Butanol	1-Butanol (see all 10)	71-36-3	--
1-Hexanol	1-Hexyl alcohol (see all 30)	111-27-3	--
1-Pentanol	1-Pentol (see all 34)	71-41-0	--
4-Nitrophenol	1-Hydroxy-4-nitrobenzene (see all 8)	100-02-7	--
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Acetic acid	Acetate (see all 12)	64-19-7	--
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Diethylthiophosphate	DETP (see all 6)	5871-17-0	--
Ethanol	1-Hydroxyethane (see all 57)	64-17-5	--

2 DrugBank Compounds for PON3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Edetic Acid	CaEDTA (see all 8)	62-33-9	enzyme	inhibitor	17292339
Lovastatin	6 alpha-Methylcompactin (see all 4)	75330-75-5	enzyme	substrate	10931838

4 Novoseek chemical compound relationships for PON3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
phenylacetate	83.7	1	11304470 (1)
paraoxon	76.9	1	11304470 (1)
lovastatin	36.5	1	15772423 (1)
cholesterol	33.1	2	18585453 (2)

Search CenterWatch for drugs/clinical trials and news about PON3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PON3 gene:

NM_000940.2

Unigene Cluster for PON3:

Paraoxonase 3

Hs.440967 [show with all ESTs]

Unigene Representative Sequence: CD014095

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000265627(uc003unt.3) ENST00000427422 ENST00000451904 ENST00000418617

ENST00000442770 ENST00000456855 ENST00000492800 ENST00000460248 ENST00000482624(uc011kii.2)

ENST00000475439

miRNA Products:		OriGene 3'-UTR Clone: PON3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PON3
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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PON3 (see all 7) OriGene shRNA RFP: PON3 OriGene siRNA: PON3
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PON3

Additional cDNA sequence:

AF320003.1 AF329433.1 AK304282.1 BC020908.1 BC070374.1 L48516.1

18 DOTS entries:

DT.313453 DT.92425664 DT.92425663 DT.101983699 DT.40121264 DT.101983703 DT.92425666 DT.100731698

DT.100738978 DT.100762569 DT.101983700 DT.101983701 DT.40121265 DT.92425659 DT.92425662 DT.100653477

DT.101983702 DT.75151092

24/80 AceView cDNA sequences (see all 80):

AI866611 AI866606 AV653103 BF513914 BF059348 CD014095 NM_000940 AA256367

CD014100 AV660412 CD014102 AI674127 CD014098 CB160649 AV720018 AI033844

CD014096 AF329433 BU071352 AI074616 AI247797 T81888 AV648699 T71213

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PON3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAAAATTCT

About this image

PON3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PON3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PON3

SOURCE GeneReport for Unigene cluster: Hs.440967

SABiosciences Expression via Pathway-Focused PCR Array including PON3:

Drug Metabolism in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PON3 gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PON2⁶	Uncharacterized protein	61(a)	1 → many	2(23811551-23827703)
lizard (Anolis carolinensis)	Reptilia	--	--	57(a)	1 → many	6(22507087-22522423)
zebrafish (Danio rerio)	Actinopterygii	zgc:112374⁶ zgc:77556⁶ (see all 3)	zgc:77556 (see all 3)	49(a) 49(a) (see all 3)	many ↔ many many ↔ many (see all 3)	16(26896251-26907913) 16(26909176-26912212)
worm (Caenorhabditis elegans)	Secernentea	poml-2¹	Protein POML-2	44.54(n) 30.68(a)		171999 NM_058905.3 NP_491306.1

ENSEMBL Gene Tree for PON3 (if available)
TreeFam Gene Tree for PON3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PON3 gene

PON1² PON2²

2 SIMAP similar genes for PON3 using alignment to 5 protein entries: PON3_HUMAN (see all proteins):

PON2 PON1

PON3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17882643^1,2	C	--	94317976(-)	`TAACTG/AGGTCC`	1	--	ds500¹		2	NS	82
rs200019628^1,2	C	--	94318298(+)	`CTCACA/GGTACA`	2	R C	mis¹		1	EU	1321
rs73709962^1,2	C	--	94318724(+)	`CTCTTA/GTTTAG`	1	--	int¹		2	WA	120
rs17878798^1,2	C,F	--	94318746(-)	`AGGACC/TACCAT`	1	--	int¹		3	NS WA	210
rs17879079^1,2	C	--	94318796(-)	`TTTCTC/GTCCCC`	1	--	int¹ trp³		2	NS	92
rs73432772^1,2	C	--	94318947(+)	`TTCATT/CTGACA`	1	--	int¹		4	WA NA EA	360
rs17882955^1,2	C,F	--	94319107(-)	`TTCTAA/TTTGTT`	1	--	int¹		3	NS WA	212
rs17883235^1,2	C	--	94319126(-)	`AGACTC/TGTAAC`	1	--	int¹		2	NS	94
rs7778771^1,2	C,F,H	--	94319338(+)	`GATACG/AAAAAA`	1	--	int¹		11	NS EA NA WA	728
rs7797694^1,2	C,F,H	--	94319406(+)	`CATTGT/CGGTTG`	1	--	int¹		12	NS EA NA WA	758

HapMap Linkage Disequilibrium report for PON3 (94989184 - 95025687 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PON3: --
Human Gene Mutation Database (HGMD): PON3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PON3

DNA2.0 Custom Variant and Variant Library Synthesis for PON3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PON3 for disorders           About GeneDecksing

OMIM gene information: 602720    OMIM disorders: --

15 diseases for PON3:    About MalaCards

atherosclerosis coronary heart disease amyotrophic lateral sclerosis myocardial infarction

lateral sclerosis acute myocardial infarction cataract hepatocellular carcinoma

alzheimer's disease dementia colorectal cancer obesity

cholesterol carcinoma alcoholism

1 disease from the University of Copenhagen DISEASES database for PON3:

Atherosclerosis

4 Novoseek disease relationships for PON3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
atherosclerosis	60	13	17446441 (3), 17379834 (2), 11304457 (1), 19359600 (1) (see all 9)
coronary heart disease	43.4	2	11803456 (1), 16120573 (1)
cardiovascular diseases	37.3	2	11803456 (1), 19082953 (1)
stroke	0	1	16239632 (1)

Genetic Association Database (GAD): PON3
Human Genome Epidemiology (HuGE) Navigator: PON3 (36 documents)

Export disorders for PON3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PON3 gene, integrated from 9 sources (see all 97):
(articles sorted by number of sources associating them with PON3)

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The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. (PubMed id 8661009)^{1, 2, 3, 9} Primo-Parmo S.L.... La Du B.N. (1996)
Identification of paraoxonase 3 gene (PON3) missense mutations in a population of southern Italy. (PubMed id 14757195)^{1, 4, 9} Campo S....Saitta A. (2004)
Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. (PubMed id 15772423)^{1, 2, 9} Draganov D.I....La Du B.N. (2005)
Paraoxonase gene cluster variations associated with coronary heart disease in Chinese Han women. (PubMed id 16117861)^{1, 4, 9} Su S.Y....Gu D.F. (2005)
[Association analysis between polymorphisms of PON gene cluster with coronary heart disease in Chinese] (PubMed id 16078734)^{1, 4, 9} Wang X.L....Gu D.F. (2005)
PON1 M/L55 mutation protects high-risk patients against coronary artery disease. (PubMed id 14996478)^{1, 4, 9} Oliveira S.A....Annichino-Bizzacchi J.M. (2004)
Human paraoxonase gene cluster polymorphisms as predictors of coronary heart disease risk in the prospective Northwick Park Heart Study II. (PubMed id 14636952)^{1, 4, 9} Robertson K.S....Humphries S.E. (2003)
Extensive association analysis between polymorphisms of PON gene cluster with coronary heart disease in Chinese Han population. (PubMed id 12588779)^{1, 4, 9} Wang X....Gu D. (2003)
Polymorphisms in the PON gene cluster are associated with Alzheimer disease. (PubMed id 16319130)^{1, 4} Erlich P.M....Farrer L.A. (2006)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5446	HGNC: 9206	AceView: PON3	Ensembl:ENSG00000105852	euGenes: HUgn5446
ECgene: PON3	Kegg: 5446	H-InvDB: PON3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PON3	Pharmacogenomics, SNPs, Pathways
SeattleSNPs	http://pga.gs.washington.edu/data/pon3/

Intellectual Property for PON3 gene
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Patent Information for PON3 gene:
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