Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PON2 Gene

Aliases for PON2 Gene

  • Paraoxonase 2 2 3 5
  • Serum Aryldialkylphosphatase 2 4
  • Aromatic Esterase 2 4
  • Paraoxonase Nirs 2
  • Arylesterase 2 2
  • A-Esterase 2 4
  • EC 3.1.1.81 4
  • EC 3.1.1.2 4
  • PON 2 4

External Ids for PON2 Gene

Previous GeneCards Identifiers for PON2 Gene

  • GC07M093569
  • GC07M094632
  • GC07M094646
  • GC07M094678
  • GC07M094872
  • GC07M095034
  • GC07M089641

Summaries for PON2 Gene

Entrez Gene Summary for PON2 Gene

  • This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for PON2 Gene

PON2 (Paraoxonase 2) is a Protein Coding gene. Diseases associated with PON2 include amyotrophic lateral sclerosis 1 and multiple chemical sensitivity. Among its related pathways are Metabolism and Phase I, non P450. GO annotations related to this gene include identical protein binding and arylesterase activity. An important paralog of this gene is PON3.

UniProtKB/Swiss-Prot for PON2 Gene

  • Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.

Gene Wiki entry for PON2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PON2 Gene

Genomics for PON2 Gene

Regulatory Elements for PON2 Gene

Promoters for PON2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PON2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PON2 Gene

Chromosome:
7
Start:
95,404,862 bp from pter
End:
95,435,329 bp from pter
Size:
30,468 bases
Orientation:
Minus strand

Genomic View for PON2 Gene

Genes around PON2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PON2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PON2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PON2 Gene

Proteins for PON2 Gene

  • Protein details for PON2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15165-PON2_HUMAN
    Recommended name:
    Serum paraoxonase/arylesterase 2
    Protein Accession:
    Q15165
    Secondary Accessions:
    • A4D1H7
    • B2RCP9
    • B4DJD5
    • O15114
    • O15115
    • O75856
    • Q5FBX7
    • Q86YL0

    Protein attributes for PON2 Gene

    Size:
    354 amino acids
    Molecular mass:
    39397 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homotrimer.

    Alternative splice isoforms for PON2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PON2 Gene

Proteomics data for PON2 Gene at MOPED

Post-translational modifications for PON2 Gene

Antibody Products

No data available for DME Specific Peptides for PON2 Gene

Domains & Families for PON2 Gene

Gene Families for PON2 Gene

Protein Domains for PON2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15165

UniProtKB/Swiss-Prot:

PON2_HUMAN :
  • Belongs to the paraoxonase family.
Family:
  • Belongs to the paraoxonase family.
genes like me logo Genes that share domains with PON2: view

Function for PON2 Gene

Molecular function for PON2 Gene

GENATLAS Biochemistry:
paraoxonase-like sequence 1(PON2),susceptibility locus for coronary heart disease,ubiquitously expressed
UniProtKB/Swiss-Prot CatalyticActivity:
A phenyl acetate + H(2)O = a phenol + acetate.
UniProtKB/Swiss-Prot CatalyticActivity:
An N-acyl-L-homoserine lactone + H(2)O = an N-acyl-L-homoserine.
UniProtKB/Swiss-Prot Function:
Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.

Enzyme Numbers (IUBMB) for PON2 Gene

Gene Ontology (GO) - Molecular Function for PON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IDA 15772423
genes like me logo Genes that share ontologies with PON2: view
genes like me logo Genes that share phenotypes with PON2: view

Human Phenotype Ontology for PON2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PON2 Gene

Localization for PON2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PON2 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PON2 Gene COMPARTMENTS Subcellular localization image for PON2 gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 3
lysosome 3
mitochondrion 3
vacuole 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005739 mitochondrion IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with PON2: view

Pathways & Interactions for PON2 Gene

SuperPathways for PON2 Gene

Superpath Contained pathways
1 Metabolism
2 Phase I, non P450
genes like me logo Genes that share pathways with PON2: view

Pathways by source for PON2 Gene

1 BioSystems pathway for PON2 Gene
1 KEGG pathway for PON2 Gene

Gene Ontology (GO) - Biological Process for PON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
genes like me logo Genes that share ontologies with PON2: view

No data available for SIGNOR curated interactions for PON2 Gene

Drugs & Compounds for PON2 Gene

(7) Drugs for PON2 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenol Approved, Experimental Pharma 43
acetic acid Approved Nutra Full agonist, Agonist 89
1-Butanol Experimental Pharma 0
1-Proponol Experimental Pharma 0
4-Nitrophenol Experimental Pharma 0

(14) Additional Compounds for PON2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Hexanol
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
111-27-3
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
71-41-0
4-Hydroxyphenyl acetate
Diethylphosphate
  • DEP
  • Di-Ethyl phosphate
  • Diethyl acid phosphate
  • Diethyl hydrogen phosphate
  • Diethyl phosphate
598-02-7
Diethylthiophosphate
  • DETP
  • Diethylthiophosphate
  • Diethylthiophosphorate
  • Diethylthiophosphoric acid
  • O,O-Diethyl phosphorothionate
5871-17-0
genes like me logo Genes that share compounds with PON2: view

Transcripts for PON2 Gene

Unigene Clusters for PON2 Gene

Paraoxonase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PON2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a ·
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: -
SP8: - - -
SP9: - - - - - - -
SP10:
SP11: -
SP12: -

ExUns: 9b ^ 10a · 10b · 10c · 10d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for PON2 Gene

GeneLoc Exon Structure for
PON2
ECgene alternative splicing isoforms for
PON2

Expression for PON2 Gene

mRNA expression in normal human tissues for PON2 Gene

Protein differential expression in normal tissues from HIPED for PON2 Gene

This gene is overexpressed in Adrenal (8.5), Fetal Liver (7.5), and Testis (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PON2 Gene



SOURCE GeneReport for Unigene cluster for PON2 Gene Hs.744912

mRNA Expression by UniProt/SwissProt for PON2 Gene

Q15165-PON2_HUMAN
Tissue specificity: Widely expressed with highest expression in liver, lung, placenta, testis and heart.
genes like me logo Genes that share expression patterns with PON2: view

Protein tissue co-expression partners for PON2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PON2 Gene

Orthologs for PON2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PON2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PON2 36
  • 94 (a)
OneToOne
PON2 35
  • 99.81 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia PON2 36
  • 93 (a)
OneToOne
PON2 35
  • 92.47 (n)
  • 93.22 (a)
dog
(Canis familiaris)
Mammalia PON2 35
  • 91.99 (n)
  • 93.47 (a)
PON2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pon2 16
Pon2 36
  • 88 (a)
OneToOne
Pon2 35
  • 86.44 (n)
  • 88.14 (a)
oppossum
(Monodelphis domestica)
Mammalia PON2 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pon2 35
  • 86.44 (n)
  • 89.83 (a)
chicken
(Gallus gallus)
Aves PON2 35
  • 72.79 (n)
  • 74.29 (a)
PON2 36
  • 74 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pon2 35
  • 64.97 (n)
  • 64.97 (a)
Str.1885 35
zebrafish
(Danio rerio)
Actinopterygii pon1 36
  • 53 (a)
ManyToMany
pon2 36
  • 54 (a)
ManyToMany
zgc:174637 36
  • 53 (a)
ManyToMany
zgc:174637 36
  • 55 (a)
ManyToMany
Dr.20841 35
pon3 35
  • 59.5 (n)
  • 56.42 (a)
worm
(Caenorhabditis elegans)
Secernentea mec-6 36
  • 20 (a)
ManyToMany
poml-2 36
  • 27 (a)
ManyToMany
poml-3 36
  • 28 (a)
ManyToMany
poml-4 36
  • 27 (a)
ManyToMany
Species with no ortholog for PON2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PON2 Gene

ENSEMBL:
Gene Tree for PON2 (if available)
TreeFam:
Gene Tree for PON2 (if available)

Paralogs for PON2 Gene

Paralogs for PON2 Gene

(2) SIMAP similar genes for PON2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PON2: view

Variants for PON2 Gene

Sequence variations from dbSNP and Humsavar for PON2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs12026 - 95,411,704(-) AGAAG(C/G)AGAAA reference, missense
rs7493 - 95,405,463(-) TCTAT(C/G)TGAGA reference, missense
rs17876152 - 95,410,082(-) CAGCT(C/G)TTGGA reference, missense
rs987539 -- 95,407,680(+) TGTTG(C/T)AGCAG intron-variant
rs1034808 -- 95,415,502(+) AGGTT(A/G)GTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PON2 Gene

Variant ID Type Subtype PubMed ID
nsv888752 CNV Gain 21882294
nsv888753 CNV Loss 21882294
nsv888754 CNV Gain 21882294

Variation tolerance for PON2 Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.15; 95.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PON2 Gene

HapMap Linkage Disequilibrium report
PON2
Human Gene Mutation Database (HGMD)
PON2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PON2 Gene

Disorders for PON2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for PON2 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
multiple chemical sensitivity
  • 20th century disease
hypercholesterolemia, familial
  • hypercholesterolemia, familial, modifier of
heart disease
  • heart diseases
coronary artery disease
  • coronary artery anomaly
- elite association - COSMIC cancer census association via MalaCards
Search PON2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PON2

Genetic Association Database (GAD)
PON2
Human Genome Epidemiology (HuGE) Navigator
PON2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PON2
genes like me logo Genes that share disorders with PON2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PON2 Gene

Publications for PON2 Gene

  1. The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. (PMID: 8661009) Primo-Parmo S.L. … La Du B.N. (Genomics 1996) 2 3 4 23 67
  2. Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence. (PMID: 9714608) Mochizuki H. … Prochazka M. (Gene 1998) 2 3 23
  3. The role of polymorphisms within paraoxonases (192 Gln/Arg in PON1 and 311Ser/Cys in PON2) in the modulation of cardiovascular risk: a pilot study. (PMID: 19939821) Gluba A. … Rysz J. (Angiology 2010) 3 23
  4. Human tissue distribution of paraoxonases 1 and 2 mRNA. (PMID: 20503442) Mackness B. … Mackness M. (IUBMB Life 2010) 3 23
  5. Comparative expression analysis reveals differences in the regulation of intestinal paraoxonase family members. (PMID: 19401157) Precourt L.P. … Levy E. (Int. J. Biochem. Cell Biol. 2009) 3 23

Products for PON2 Gene

Sources for PON2 Gene

Back to Top

Content