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Aliases for POMZP3 Gene

Aliases for POMZP3 Gene

  • POM121 And ZP3 Fusion 2 3
  • POM (POM121 Homolog, Rat) And ZP3 Fusion 2 3
  • POM (POM121 Rat Homolog) And ZP3 Fusion 2 3
  • POM121/ZP3 Fusion Protein 2 3
  • POM-ZP3 Fusion Protein 2 3
  • POM-ZP3 3 4
  • POM121 And ZP3 Fusion Protein 3
  • POM121 3

External Ids for POMZP3 Gene

Summaries for POMZP3 Gene

Entrez Gene Summary for POMZP3 Gene

  • This gene appears to have resulted from a fusion of DNA sequences derived from 2 distinct loci, specifically through the duplication of two internal exons from the POM121 gene and four 3' exons from the ZP3 gene. The 5' end of this gene is similar to the 5` coding region of the POM121 gene which encodes an integral nuclear pore membrane protein. However, the protein encoded by this gene lacks the nuclear pore localization motif. The 3' end of this gene is similar to the last 4 exons of the zona pellucida glycoprotein 3 (ZP3) gene and the encoded protein retains one zona pellucida domain. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for POMZP3 Gene

POMZP3 (POM121 And ZP3 Fusion) is a Protein Coding gene. Among its related pathways are Disease and Cell Cycle, Mitotic. An important paralog of this gene is ZP3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POMZP3 Gene

Genomics for POMZP3 Gene

Genomic Location for POMZP3 Gene

Start:
76,609,986 bp from pter
End:
76,627,303 bp from pter
Size:
17,318 bases
Orientation:
Minus strand

Genomic View for POMZP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POMZP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POMZP3 Gene

Regulatory Elements for POMZP3 Gene

Proteins for POMZP3 Gene

  • Protein details for POMZP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PJE2-POZP3_HUMAN
    Recommended name:
    POM121 and ZP3 fusion protein
    Protein Accession:
    Q6PJE2
    Secondary Accessions:
    • F6STJ3
    • Q12903
    • Q9BWB4

    Protein attributes for POMZP3 Gene

    Size:
    187 amino acids
    Molecular mass:
    20620 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA85788.1; Type=Frameshift; Positions=187; Evidence={ECO:0000305};

    Alternative splice isoforms for POMZP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POMZP3 Gene

Proteomics data for POMZP3 Gene at MOPED

Post-translational modifications for POMZP3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys74

Other Protein References for POMZP3 Gene

No data available for DME Specific Peptides for POMZP3 Gene

Domains for POMZP3 Gene

Protein Domains for POMZP3 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with POMZP3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for POMZP3 Gene

Function for POMZP3 Gene

Molecular function for POMZP3 Gene

GENATLAS Biochemistry: bipartite transcript for ZP3 (see FP3B) and a nuclear pore membrane,protein homolog to rat protein POM121

Gene Ontology (GO) - Molecular Function for POMZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with POMZP3: view

miRNA for POMZP3 Gene

miRTarBase miRNAs that target POMZP3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for POMZP3 Gene

Localization for POMZP3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POMZP3 Gene COMPARTMENTS Subcellular localization image for POMZP3 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for POMZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with POMZP3: view

Pathways for POMZP3 Gene

SuperPathways for POMZP3 Gene

genes like me logo Genes that share pathways with POMZP3: view

Pathways by source for POMZP3 Gene

42 Reactome pathways for POMZP3 Gene
1 KEGG pathway for POMZP3 Gene

Interacting Proteins for POMZP3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309233%0d%0a9606.ENSP00000243346%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000309233 Q6PJE2-POZP3_HUMAN for POMZP3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for POMZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with POMZP3: view

Transcripts for POMZP3 Gene

Unigene Clusters for POMZP3 Gene

POM121 and ZP3 fusion:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POMZP3 Gene

No ASD Table

Relevant External Links for POMZP3 Gene

GeneLoc Exon Structure for
POMZP3
ECgene alternative splicing isoforms for
POMZP3

Expression for POMZP3 Gene

mRNA expression in normal human tissues for POMZP3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for POMZP3 Gene

SOURCE GeneReport for Unigene cluster for POMZP3 Gene Hs.488877

mRNA Expression by UniProt/SwissProt for POMZP3 Gene

Q6PJE2-POZP3_HUMAN
Tissue specificity: Expressed in spleen, thymus, pancreas, testis, ovary, small intestine, colon and lymphocytes.
genes like me logo Genes that share expressions with POMZP3: view

Orthologs for POMZP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for POMZP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POMZP3 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zp3 37
  • 20 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 19 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 15 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ZP3 37
  • 17 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 17 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:171779 37
  • 10 (a)
ManyToMany
zgc:173556 37
  • 10 (a)
ManyToMany
zp3.2 37
  • 10 (a)
ManyToMany
zp3.2 37
  • 10 (a)
ManyToMany
zp3a.1 37
  • 11 (a)
ManyToMany
zp3a.2 37
  • 11 (a)
ManyToMany
zp3b 37
  • 8 (a)
ManyToMany
Species with no ortholog for POMZP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POMZP3 Gene

ENSEMBL:
Gene Tree for POMZP3 (if available)
TreeFam:
Gene Tree for POMZP3 (if available)

Paralogs for POMZP3 Gene

Paralogs for POMZP3 Gene

Pseudogenes.org Pseudogenes for POMZP3 Gene

genes like me logo Genes that share paralogs with POMZP3: view

Variants for POMZP3 Gene

Sequence variations from dbSNP and Humsavar for POMZP3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs236605 -- 76,628,992(+) GCTCT(C/T)TGAAC upstream-variant-2KB
rs111436310 -- 76,629,117(+) CCTGA(A/G)CCCTC upstream-variant-2KB
rs112023568 -- 76,629,116(+) GCCTG(A/G)GCCCT upstream-variant-2KB
rs146878550 -- 76,629,146(+) GAGGT(A/T)AAGAG upstream-variant-2KB
rs199652471 -- 76,629,080(+) GATGA(C/T)TGAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for POMZP3 Gene

Variant ID Type Subtype PubMed ID
nsv528969 CNV Gain 19592680
essv14753 CNV CNV 17122850
dgv120n16 CNV Deletion 17901297
dgv2104e1 CNV Complex 17122850
esv2422494 CNV Duplication 17116639
nsv428174 CNV Gain 18775914
dgv232e55 CNV Gain 17911159
dgv2106e1 CNV Complex 17122850
dgv233e55 CNV Loss 17911159
nsv7403 OTHER Inversion 18451855
dgv2107e1 CNV Complex 17122850
dgv234e55 CNV Gain 17911159
dgv235e55 CNV Loss 17911159
nsv517634 CNV Gain+Loss 19592680
dgv7327n71 CNV Gain 21882294
dgv1218e199 CNV Deletion 23128226
nsv888391 CNV Loss 21882294
esv2734687 CNV Deletion 23290073
nsv888395 CNV Loss 21882294
dgv7328n71 CNV Gain 21882294
dgv121n16 CNV Insertion 17901297
nsv888401 CNV Gain+Loss 21882294
nsv888410 CNV Gain 21882294
dgv7329n71 CNV Gain 21882294
dgv7330n71 CNV Gain 21882294
dgv7331n71 CNV Loss 21882294
dgv63n64 CNV Loss 17921354
esv23975 CNV Gain+Loss 19812545
dgv22n31 CNV Duplication 19718026
nsv824177 CNV Gain 20364138
dgv7332n71 CNV Gain 21882294
nsv888431 CNV Gain 21882294
nsv888440 CNV Gain 21882294
esv2421739 OTHER Complex 20811451
dgv64n64 CNV Gain 17921354
dgv822n27 CNV Loss 19166990
dgv823n27 CNV Gain 19166990
nsv470321 CNV Gain 18288195
dgv7334n71 CNV Gain+Loss 21882294
dgv2108e1 CNV Complex 17122850
nsv471447 CNV Duplication 19718026
esv2422423 CNV Duplication 17116639

Relevant External Links for POMZP3 Gene

HapMap Linkage Disequilibrium report
POMZP3

Disorders for POMZP3 Gene

Relevant External Links for POMZP3

Genetic Association Database (GAD)
POMZP3
genes like me logo Genes that share disorders with POMZP3: view

No data available for UniProtKB/Swiss-Prot for POMZP3 Gene

Publications for POMZP3 Gene

  1. POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121 homologue. (PMID: 7789967) Kipersztok S. … Dean J. (Genomics 1995) 2 3 4 23
  2. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington J.J. … Ducar M. (Nat. Biotechnol. 2001) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Nuclear pore complex assembly and maintenance in POM121- and gp210-deficient cells. (PMID: 16702234) Stavru F. … GAPrlich D. (J. Cell Biol. 2006) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for POMZP3 Gene

Sources for POMZP3 Gene

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