POMZP3 Gene
protein-coding GIFtS: 44
GCID: GC07M076239
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POM121 and ZP3 fusion(Previous names: POM (POM121 rat homolog) and ZP3 fusion, POM (POM121 homolog,...)
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Aliases
for POMZP3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
|---|
| POM121 And ZP3 Fusion1 2 | | POM (POM121 Rat Homolog) And ZP3 Fusion1 2 | | POM-ZP31 2 3 | | POM-ZP3 Fusion Protein2 | | POM1211 2 | | POM121 And ZP3 Fusion Protein2 | | POM (POM121 Homolog, Rat) And ZP3 Fusion1 2 | | POM121/ZP3 Fusion Protein2 |
Export aliases for POMZP3 gene to outside databasesPrevious GC identifers: GC07U990154 GC07M074775 GC07M075837 GC07M075851 GC07M075883 GC07M076077 GC07M075572 |
Summaries
for POMZP3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for POMZP3:
This gene appears to have resulted from a fusion of DNA sequences derived from 2 distinct loci, specifically throughthe duplication of two internal exons from the POM121 gene and four 3' exons from the ZP3 gene. The 5' end of thisgene is similar to the 5` coding region of the POM121 gene which encodes an integral nuclear pore membrane protein.However, the protein encoded by this gene lacks the nuclear pore localization motif. The 3' end of this gene issimilar to the last 4 exons of the zona pellucida glycoprotein 3 (ZP3) gene and the encoded protein retains one zonapellucida domain. Multiple protein isoforms are encoded by transcript variants of this gene. (provided by RefSeq, Jul2008)
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Genomic Views
for POMZP3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the POMZP3 gene promoter:
USF1 p53 USF2 HEN1 MZF-1 S8 USF-1 Pax-4a Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for POMZP3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POMZP3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.2POMZP3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M076239: view genomic region
(about GC identifiers)
Start:
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76,239,303 bp from pter |
End:
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76,256,620 bp from pter |
Size:
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17,318 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 75,572,366-75,589,683 |
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Proteins
for POMZP3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: POZP3_HUMAN, Q6PJE2 (See
protein sequence)Recommended Name: POM121 and ZP3 fusion protein Size: 187 amino acids; 20620 Da
Caution: The POM-ZP3 transcript appears to have arisen from a partial duplication and fusion of a 5' portion of aPOM121 homolog and exons 5-8 of ZP3
Sequence caution: Sequence=AAA85788.1; Type=Frameshift; Positions=187;
Secondary accessions: F6STJ3 Q12903 Q9BWB4Alternative splicing: 2 isoforms: Q6PJE2-4 Q6PJE2-5 (No experimental confirmation available. Gene prediction based on EST data)Explore the universe of human proteins at neXtProt for POMZP3: NX_Q6PJE2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6PJE2
POMZP3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_036362.3 NP_694537.1
ENSEMBL proteins: ENSP00000275569 ENSP00000309233 ENSP00000416963 ENSP00000416591 ENSP00000405319
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005575 | cellular_component |
ND | -- |
POMZP3 for ontologies About GeneDecksing
POMZP3 Antibody Products:
Assay Products for POMZP3: |
Protein
Domains /
Families
for POMZP3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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POMZP3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6PJE2ProtoNet protein and cluster: Q6PJE2 |
Function
for POMZP3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for POMZP3:bipartite transcript for ZP3 (see FP3B) and a nuclear pore membrane,protein homolog to rat protein POM121
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POMZP3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POMZP3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POMZP3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0003674 | molecular_function |
ND | -- |
POMZP3 for ontologies About GeneDecksing
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Pathways & Interactions
for POMZP3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POMZP3
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for POMZP3 (Q6PJE23 ENSP000003092334) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0008150 | biological_process |
ND | -- |
POMZP3 for ontologies About GeneDecksing
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Drugs & Compounds
for POMZP3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for POMZP3
Search CenterWatch for drugs/clinical trials and news about POMZP3 / POZP3
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Transcripts
for POMZP3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for POMZP3 gene (2 alternative transcripts): NM_012230.3 NM_152992.2 Unigene Cluster for POMZP3: POM121 and ZP3 fusion Hs.488877 [show with all ESTs]Unigene Representative Sequence: NM_0122306 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000454656 ENST00000275569 ENST00000310842(uc003uft.3 uc003ufu.3)
ENST00000441393 ENST00000424818(uc011kgm.2) ENST00000454397
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POMZP3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POMZP3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): POMZP3 (NM_152992) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POMZP3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POMZP3 |
Additional cDNA sequence: BC000487.2 BC017101.1 BC144677.1 U10099.1 12 DOTS entries: DT.92469787 DT.121090535 DT.95145207 DT.95145133 DT.121067326 DT.121090571 DT.121637693 DT.95145124 DT.100027278 DT.95293148 DT.95362005 DT.97769393 24/159 AceView cDNA sequences (see all 159): BQ446470 BF063092 AW162786 AI802299 BF195407 CR616549 AI075996 CR603033 AI359326 BF726964 R52115 AA479708 CA421411 NM_012230 BQ961240 BV205867 U10099 NM_152992 BQ673059 AI423074 BU172163 AA334719 AW163456 AI640266
GeneLoc Exon Structure
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Expression
for POMZP3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| POMZP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See POMZP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POMZP3
SOURCE GeneReport for Unigene cluster: Hs.488877
UniProtKB/Swiss-Prot: POZP3_HUMAN, Q6PJE2Tissue specificity: Expressed in spleen, thymus, pancreas, testis, ovary, small intestine, colon and lymphocytes
SABiosciences Custom PCR Arrays for POMZP3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POMZP3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat POMZP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POMZP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POMZP3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POMZP3 |
Orthologs
for POMZP3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for POMZP3 gene from 3/7 species (see all 7) About this table
Species with no ortholog for POMZP3
ENSEMBL Gene Tree for POMZP3 (if available)
TreeFam Gene Tree for POMZP3 (if available) |
Paralogs
for POMZP3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for POMZP3 gene
- ZP32
18/24 SIMAP similar genes for POMZP3 using alignment to 5 protein entries: POZP3_HUMAN (see all proteins)
(see all similar genes):POM121C FAM3A ZP3 FAM138D AURA2 FAM138A
FAM138B FAM138C FAM138F POM121 KIAA1651 NF2
UTY FP6651 FAM175A FLJ20555 DNAPTP3 TIGD1L2
POMZP3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for POMZP3
PGOHUM00000244500
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Genomic Variants
for POMZP3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for POMZP3 (76239303 - 76256620 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 25 variations for POMZP3
15/25 CNVs (see all 25): 29786 2700 8568 9060 52285 52284 3686 52286 52283 10191 34497 52288 8569 22956 29785 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POMZP3 |
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Disorders
/ Diseases
for POMZP3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 POMZP3 for disorders About MalaCards
POMZP3 for disorders About GeneDecksing
OMIM gene information: 600587
OMIM disorders: --
Export disorders for POMZP3 gene to outside databases
|
Publications
for POMZP3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for POMZP3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with POMZP3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121 homologue. (PubMed id 7789967)1, 2, 3, 9 Kipersztok S.... Dean J. (1995)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Nuclear pore complex assembly and maintenance in POM121- and gp210-deficient cells. (PubMed id 16702234)1 Stavru F....Gorlich D. (2006)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (2001)
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External Searches for POMZP3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing POMZP3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing POMZP3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing POMZP3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for POMZP3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for POMZP3 gene:
Search GeneIP for patents involving POMZP3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for POMZP3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for POMZP3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POMZP3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POMZP3 | | | OriGene Protein Over-expression Lysate for POMZP3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for POMZP3 | | OriGene 3'-UTR Clone for POMZP3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POMZP3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POMZP3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for POMZP3 | | OriGene Custom Protein Services for POMZP3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POMZP3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POMZP3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POMZP3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POMZP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POMZP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POMZP3 |
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 |  |  |  | |
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 | | | POMZP3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POMZP3 |
|  |  |  | | | | Search ThermoFisher Antibodies for POMZP3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POMZP3 |
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