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Aliases for POMZP3 Gene

Aliases for POMZP3 Gene

  • POM121 And ZP3 Fusion 2 3 5
  • POM (POM121 Homolog, Rat) And ZP3 Fusion 2 3
  • POM (POM121 Rat Homolog) And ZP3 Fusion 2 3
  • POM121/ZP3 Fusion Protein 2 3
  • POM-ZP3 Fusion Protein 2 3
  • POM-ZP3 3 4
  • POM121 3

External Ids for POMZP3 Gene

Previous GeneCards Identifiers for POMZP3 Gene

  • GC07U990154
  • GC07M074775
  • GC07M075837
  • GC07M075851
  • GC07M075883
  • GC07M076077
  • GC07M076239
  • GC07M075572

Summaries for POMZP3 Gene

Entrez Gene Summary for POMZP3 Gene

  • This gene appears to have resulted from a fusion of DNA sequences derived from 2 distinct loci, specifically through the duplication of two internal exons from the POM121 gene and four 3' exons from the ZP3 gene. The 5' end of this gene is similar to the 5` coding region of the POM121 gene which encodes an integral nuclear pore membrane protein. However, the protein encoded by this gene lacks the nuclear pore localization motif. The 3' end of this gene is similar to the last 4 exons of the zona pellucida glycoprotein 3 (ZP3) gene and the encoded protein retains one zona pellucida domain. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for POMZP3 Gene

POMZP3 (POM121 And ZP3 Fusion) is a Protein Coding gene. An important paralog of this gene is ZP3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POMZP3 Gene

Genomics for POMZP3 Gene

Regulatory Elements for POMZP3 Gene

Enhancers for POMZP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POMZP3 on UCSC Golden Path with GeneCards custom track

Promoters for POMZP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POMZP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for POMZP3 Gene

76,609,986 bp from pter
76,627,303 bp from pter
17,318 bases
Minus strand

Genomic View for POMZP3 Gene

Genes around POMZP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POMZP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POMZP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POMZP3 Gene

Proteins for POMZP3 Gene

  • Protein details for POMZP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    POM121 and ZP3 fusion protein
    Protein Accession:
    Secondary Accessions:
    • F6STJ3
    • Q12903
    • Q9BWB4

    Protein attributes for POMZP3 Gene

    187 amino acids
    Molecular mass:
    20620 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA85788.1; Type=Frameshift; Positions=187; Evidence={ECO:0000305};

    Alternative splice isoforms for POMZP3 Gene


neXtProt entry for POMZP3 Gene

Proteomics data for POMZP3 Gene at MOPED

Post-translational modifications for POMZP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POMZP3 Gene

No data available for DME Specific Peptides for POMZP3 Gene

Domains & Families for POMZP3 Gene

Protein Domains for POMZP3 Gene


Suggested Antigen Peptide Sequences for POMZP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with POMZP3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for POMZP3 Gene

Function for POMZP3 Gene

Molecular function for POMZP3 Gene

GENATLAS Biochemistry:
bipartite transcript for ZP3 (see FP3B) and a nuclear pore membrane,protein homolog to rat protein POM121

Gene Ontology (GO) - Molecular Function for POMZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032190 acrosin binding IBA --
genes like me logo Genes that share ontologies with POMZP3: view

Animal Model Products

CRISPR Products

miRNA for POMZP3 Gene

miRTarBase miRNAs that target POMZP3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POMZP3 Gene

Localization for POMZP3 Gene

Subcellular locations from

Jensen Localization Image for POMZP3 Gene COMPARTMENTS Subcellular localization image for POMZP3 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for POMZP3 Gene

Pathways & Interactions for POMZP3 Gene

SuperPathways for POMZP3 Gene

No Data Available

Interacting Proteins for POMZP3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000309233 Q6PJE2-POZP3_HUMAN for POMZP3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for POMZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035803 egg coat formation IBA --
genes like me logo Genes that share ontologies with POMZP3: view

No data available for Pathways by source and SIGNOR curated interactions for POMZP3 Gene

Drugs & Compounds for POMZP3 Gene

No Compound Related Data Available

Transcripts for POMZP3 Gene

Unigene Clusters for POMZP3 Gene

POM121 and ZP3 fusion:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POMZP3 Gene

No ASD Table

Relevant External Links for POMZP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POMZP3 Gene

mRNA expression in normal human tissues for POMZP3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POMZP3 Gene

SOURCE GeneReport for Unigene cluster for POMZP3 Gene Hs.488877

mRNA Expression by UniProt/SwissProt for POMZP3 Gene

Tissue specificity: Expressed in spleen, thymus, pancreas, testis, ovary, small intestine, colon and lymphocytes.
genes like me logo Genes that share expression patterns with POMZP3: view

Protein tissue co-expression partners for POMZP3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for POMZP3 Gene

Orthologs for POMZP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for POMZP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia -- 36
  • 19 (a)
(Mus musculus)
Mammalia Zp3 36
  • 20 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 15 (a)
(Pan troglodytes)
Mammalia POMZP3 36
  • 95 (a)
(Gallus gallus)
Aves ZP3 36
  • 17 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 17 (a)
(Danio rerio)
Actinopterygii zgc:171779 36
  • 10 (a)
zgc:173556 36
  • 10 (a)
zp3.2 36
  • 10 (a)
zp3.2 36
  • 10 (a)
zp3a.1 36
  • 11 (a)
zp3a.2 36
  • 11 (a)
zp3b 36
  • 8 (a)
Species with no ortholog for POMZP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POMZP3 Gene

Gene Tree for POMZP3 (if available)
Gene Tree for POMZP3 (if available)

Paralogs for POMZP3 Gene

Paralogs for POMZP3 Gene Pseudogenes for POMZP3 Gene

genes like me logo Genes that share paralogs with POMZP3: view

Variants for POMZP3 Gene

Sequence variations from dbSNP and Humsavar for POMZP3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_056721 -
rs782496 -- 76,628,950(+) ggtaa(C/T)agggg upstream-variant-2KB
rs236605 -- 76,628,992(+) GCTCT(C/T)TGAAC upstream-variant-2KB
rs4727219 -- 76,629,104(+) GAGAG(A/G)TCCAT upstream-variant-2KB
rs202055771 -- 76,628,994(+) TCTTT(A/G)AACTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for POMZP3 Gene

Variant ID Type Subtype PubMed ID
nsv528969 CNV Gain 19592680
essv14753 CNV CNV 17122850
dgv120n16 CNV Deletion 17901297
dgv2104e1 CNV Complex 17122850
esv2422494 CNV Duplication 17116639
nsv428174 CNV Gain 18775914
dgv232e55 CNV Gain 17911159
dgv2106e1 CNV Complex 17122850
dgv233e55 CNV Loss 17911159
nsv7403 OTHER Inversion 18451855
dgv2107e1 CNV Complex 17122850
dgv234e55 CNV Gain 17911159
dgv235e55 CNV Loss 17911159
nsv517634 CNV Gain+Loss 19592680
dgv7327n71 CNV Gain 21882294
dgv1218e199 CNV Deletion 23128226
nsv888391 CNV Loss 21882294
esv2734687 CNV Deletion 23290073
nsv888395 CNV Loss 21882294
dgv7328n71 CNV Gain 21882294
dgv121n16 CNV Insertion 17901297
nsv888401 CNV Gain+Loss 21882294
nsv888410 CNV Gain 21882294
dgv7329n71 CNV Gain 21882294
dgv7330n71 CNV Gain 21882294
dgv7331n71 CNV Loss 21882294
dgv63n64 CNV Loss 17921354
esv23975 CNV Gain+Loss 19812545
dgv22n31 CNV Duplication 19718026
nsv824177 CNV Gain 20364138
dgv7332n71 CNV Gain 21882294
nsv888431 CNV Gain 21882294
nsv888440 CNV Gain 21882294
esv2421739 OTHER Complex 20811451
dgv64n64 CNV Gain 17921354
dgv822n27 CNV Loss 19166990
dgv823n27 CNV Gain 19166990
nsv470321 CNV Gain 18288195
dgv7334n71 CNV Gain+Loss 21882294
dgv2108e1 CNV Complex 17122850
nsv471447 CNV Duplication 19718026
esv2422423 CNV Duplication 17116639

Variation tolerance for POMZP3 Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for POMZP3 Gene

Disorders for POMZP3 Gene

Relevant External Links for POMZP3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for POMZP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POMZP3 Gene

Publications for POMZP3 Gene

  1. POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121 homologue. (PMID: 7789967) Kipersztok S. … Dean J. (Genomics 1995) 2 3 4 23 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for POMZP3 Gene

Sources for POMZP3 Gene