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Aliases for POMZP3 Gene

Aliases for POMZP3 Gene

  • POM121 And ZP3 Fusion 2 3 5
  • POM (POM121 Homolog, Rat) And ZP3 Fusion 2 3
  • POM (POM121 Rat Homolog) And ZP3 Fusion 2 3
  • POM121/ZP3 Fusion Protein 2 3
  • POM-ZP3 Fusion Protein 2 3
  • POM-ZP3 3 4
  • POM121 And ZP3 Fusion Protein 3
  • POM121 3

External Ids for POMZP3 Gene

Previous GeneCards Identifiers for POMZP3 Gene

  • GC07U990154
  • GC07M074775
  • GC07M075837
  • GC07M075851
  • GC07M075883
  • GC07M076077
  • GC07M076239
  • GC07M075572

Summaries for POMZP3 Gene

Entrez Gene Summary for POMZP3 Gene

  • This gene appears to have resulted from a fusion of DNA sequences derived from 2 distinct loci, specifically through the duplication of two internal exons from the POM121 gene and four 3' exons from the ZP3 gene. The 5' end of this gene is similar to the 5` coding region of the POM121 gene which encodes an integral nuclear pore membrane protein. However, the protein encoded by this gene lacks the nuclear pore localization motif. The 3' end of this gene is similar to the last 4 exons of the zona pellucida glycoprotein 3 (ZP3) gene and the encoded protein retains one zona pellucida domain. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for POMZP3 Gene

POMZP3 (POM121 And ZP3 Fusion) is a Protein Coding gene. An important paralog of this gene is ZP3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POMZP3 Gene

Genomics for POMZP3 Gene

Regulatory Elements for POMZP3 Gene

Enhancers for POMZP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F076325 2 ENCODE 23 +300.0 300022 2.8 ATF1 MLX ARID4B FOS ZHX2 REST PPARG KAT8 NFIL3 SREBF1 POMZP3 SRRM3 ENSG00000250778 GC07M076330 PIR61421 GC07P076306
GH07F076377 1.8 FANTOM5 Ensembl ENCODE 24.1 +247.7 247669 4.1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 FOS KLF13 ZNF263 POMZP3 SSC4D RHBDD2 POR LOC100133091 ZP3 ENSG00000213548
GH07F076420 1.5 FANTOM5 Ensembl ENCODE 26.5 +204.3 204336 5.4 HDGF PKNOX1 SIN3A BRCA1 ZNF121 FOS ZNF263 REST SREBF1 SMARCA4 UPK3B ZP3 POMZP3 FAM185BP SRRM3 LOC100133091 SSC4D DTX2
GH07F076363 1.7 FANTOM5 Ensembl ENCODE 20 +262.1 262134 2.9 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS POMZP3 SSC4D POR ENSG00000213548 ZP3
GH07F076388 1.2 Ensembl ENCODE 22.9 +237.8 237840 1.3 HDAC1 PKNOX1 ARNT NFRKB YY1 CREM ZEB2 REST MEF2D ZNF589 POMZP3 LOC100133091 NSUN5P1 ZP3 ENSG00000213548
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POMZP3 on UCSC Golden Path with GeneCards custom track

Promoters for POMZP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001893170 3 2201 HDGF HDAC1 ATF1 PKNOX1 SIN3A ZNF121 FOXK2 POLR2A ZNF143 ZSCAN29

Genomic Location for POMZP3 Gene

Chromosome:
7
Start:
76,609,986 bp from pter
End:
76,627,303 bp from pter
Size:
17,318 bases
Orientation:
Minus strand

Genomic View for POMZP3 Gene

Genes around POMZP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POMZP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POMZP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POMZP3 Gene

Proteins for POMZP3 Gene

  • Protein details for POMZP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PJE2-POZP3_HUMAN
    Recommended name:
    POM121 and ZP3 fusion protein
    Protein Accession:
    Q6PJE2
    Secondary Accessions:
    • F6STJ3
    • Q12903
    • Q9BWB4

    Protein attributes for POMZP3 Gene

    Size:
    187 amino acids
    Molecular mass:
    20620 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA85788.1; Type=Frameshift; Positions=187; Evidence={ECO:0000305};

    Alternative splice isoforms for POMZP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POMZP3 Gene

Post-translational modifications for POMZP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POMZP3 Gene

No data available for DME Specific Peptides for POMZP3 Gene

Domains & Families for POMZP3 Gene

Protein Domains for POMZP3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for POMZP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with POMZP3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for POMZP3 Gene

Function for POMZP3 Gene

Molecular function for POMZP3 Gene

GENATLAS Biochemistry:
bipartite transcript for ZP3 (see FP3B) and a nuclear pore membrane,protein homolog to rat protein POM121

Gene Ontology (GO) - Molecular Function for POMZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0032190 acrosin binding IBA --
genes like me logo Genes that share ontologies with POMZP3: view

Phenotypes for POMZP3 Gene

GenomeRNAi human phenotypes for POMZP3:
genes like me logo Genes that share phenotypes with POMZP3: view

Animal Model Products

miRNA for POMZP3 Gene

miRTarBase miRNAs that target POMZP3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POMZP3 Gene

Localization for POMZP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POMZP3 gene
Compartment Confidence
nucleus 5
extracellular 4
mitochondrion 2
cytosol 2

Gene Ontology (GO) - Cellular Components for POMZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0031012 extracellular matrix IBA --
genes like me logo Genes that share ontologies with POMZP3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for POMZP3 Gene

Pathways & Interactions for POMZP3 Gene

SuperPathways for POMZP3 Gene

No Data Available

Interacting Proteins for POMZP3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309233%0d%0a9606.ENSP00000243346%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q6PJE2-POZP3_HUMAN ENSP00000309233 for POMZP3 Gene via IID MINT STRING

Gene Ontology (GO) - Biological Process for POMZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007339 binding of sperm to zona pellucida IBA --
GO:0008150 biological_process ND --
GO:0035803 egg coat formation IBA --
GO:2000344 positive regulation of acrosome reaction IBA --
genes like me logo Genes that share ontologies with POMZP3: view

No data available for Pathways by source and SIGNOR curated interactions for POMZP3 Gene

Transcripts for POMZP3 Gene

Unigene Clusters for POMZP3 Gene

POM121 and ZP3 fusion:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POMZP3 Gene

No ASD Table

Relevant External Links for POMZP3 Gene

GeneLoc Exon Structure for
POMZP3
ECgene alternative splicing isoforms for
POMZP3

Expression for POMZP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POMZP3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POMZP3 Gene



Protein tissue co-expression partners for POMZP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POMZP3 Gene:

POMZP3

SOURCE GeneReport for Unigene cluster for POMZP3 Gene:

Hs.488877

mRNA Expression by UniProt/SwissProt for POMZP3 Gene:

Q6PJE2-POZP3_HUMAN
Tissue specificity: Expressed in spleen, thymus, pancreas, testis, ovary, small intestine, colon and lymphocytes.
genes like me logo Genes that share expression patterns with POMZP3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for POMZP3 Gene

Orthologs for POMZP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for POMZP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POMZP3 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zp3 35
  • 20 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 19 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 15 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ZP3 35
  • 17 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 17 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zp3a.1 35
  • 11 (a)
ManyToMany
zp3a.2 35
  • 11 (a)
ManyToMany
zgc:171779 35
  • 10 (a)
ManyToMany
zgc:173556 35
  • 10 (a)
ManyToMany
zp3.2 35 35
  • 10 (a)
ManyToMany
zp3b 35
  • 8 (a)
ManyToMany
Species where no ortholog for POMZP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POMZP3 Gene

ENSEMBL:
Gene Tree for POMZP3 (if available)
TreeFam:
Gene Tree for POMZP3 (if available)

Paralogs for POMZP3 Gene

Paralogs for POMZP3 Gene

Pseudogenes.org Pseudogenes for POMZP3 Gene

genes like me logo Genes that share paralogs with POMZP3: view

Variants for POMZP3 Gene

Sequence variations from dbSNP and Humsavar for POMZP3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10255175 -- 76,623,576(+) ggtgg(A/G)tcacc intron-variant
rs10260184 -- 76,621,522(+) ATAGG(G/T)GCTGG intron-variant
rs10260720 -- 76,621,916(+) gcctg(C/G)gtgac intron-variant
rs1056119 -- 76,626,174(-) ACCTC(A/G)AAGAC nc-transcript-variant, utr-variant-5-prime
rs10580521 -- 76,628,791(+) AAAAA(-/G)GGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for POMZP3 Gene

Variant ID Type Subtype PubMed ID
nsv981538 CNV duplication 23825009
nsv970895 CNV duplication 23825009
nsv951361 CNV deletion 24416366
nsv824177 CNV gain 20364138
nsv7403 OTHER inversion 18451855
nsv607627 CNV loss 21841781
nsv607624 CNV gain 21841781
nsv607593 CNV gain 21841781
nsv607585 CNV gain 21841781
nsv528969 CNV gain 19592680
nsv517634 CNV gain+loss 19592680
nsv471447 CNV gain 19718026
nsv470321 CNV gain 18288195
nsv428174 CNV gain 18775914
nsv1161565 CNV duplication 26073780
nsv1144185 CNV deletion 24896259
nsv1074523 CNV deletion 25765185
nsv1034692 CNV gain+loss 25217958
esv3891147 CNV gain+loss 25118596
esv3613766 CNV loss 21293372
esv2764008 CNV gain+loss 21179565
esv2761124 CNV gain 21179565
esv2734687 CNV deletion 23290073
esv2422494 CNV duplication 17116639
esv2422423 CNV duplication 17116639
esv2421739 OTHER complex 20811451
esv23975 CNV gain+loss 19812545
dgv823n27 CNV gain 19166990
dgv822n27 CNV loss 19166990
dgv64n64 CNV gain 17921354
dgv6484n100 CNV gain 25217958
dgv6483n100 CNV loss 25217958
dgv6482n100 CNV loss 25217958
dgv6481n100 CNV gain 25217958
dgv6480n100 CNV gain 25217958
dgv6479n100 CNV gain+loss 25217958
dgv6478n100 CNV gain 25217958
dgv6477n100 CNV loss 25217958
dgv6476n100 CNV gain 25217958
dgv6475n100 CNV gain 25217958
dgv6474n100 CNV loss 25217958
dgv6473n100 CNV gain 25217958
dgv6472n100 CNV loss 25217958
dgv6471n100 CNV gain 25217958
dgv6470n100 CNV loss 25217958
dgv63n64 CNV loss 17921354
dgv235e55 CNV loss 17911159
dgv234e55 CNV gain 17911159
dgv233e55 CNV loss 17911159
dgv232e55 CNV gain 17911159
dgv22n31 CNV gain 19718026
dgv121n16 CNV insertion 17901297
dgv1218e199 CNV deletion 23128226
dgv120n16 CNV deletion 17901297
dgv11465n54 CNV loss 21841781
dgv11464n54 CNV gain 21841781

Variation tolerance for POMZP3 Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POMZP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POMZP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POMZP3 Gene

Disorders for POMZP3 Gene

Relevant External Links for POMZP3

Genetic Association Database (GAD)
POMZP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POMZP3

No disorders were found for POMZP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POMZP3 Gene

Publications for POMZP3 Gene

  1. POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121 homologue. (PMID: 7789967) Kipersztok S. … Dean J. (Genomics 1995) 2 3 4 22 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3 64
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 64
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64

Products for POMZP3 Gene

Sources for POMZP3 Gene

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