POM121C Gene
protein-coding GIFtS: 43
GCID: GC07M075046
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POM121 transmembrane nucleoporin C(Previous name: POM121 membrane glycoprotein C )
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Aliases
for POM121C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| POM121 Transmembrane Nucleoporin C1 2 | | POM121 Membrane Glycoprotein C1 2 | | Nuclear Pore Membrane Protein 121-22 3 | | Pore Membrane Protein Of 121 KDa C2 3 | | POM121-22 3 | | Nuclear Envelope Pore Membrane Protein POM 121C2 |
Export aliases for POM121C gene to outside databasesPrevious GC identifers: GC07M074884 GC07M071202 |
Summaries
for POM121C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: P121C_HUMAN, A8CG34Function: Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved inanchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation ofcytoplasmic annulate lamellae (AL)
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Genomic Views
for POM121C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the POM121C gene promoter:
RFX1 AML1a SREBP-1c E47 SREBP-1b Evi-1 PPAR-gamma1 SREBP-1a Hand1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for POM121C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POM121C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.2 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.23POM121C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M075046: view genomic region
(about GC identifiers)
Start:
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75,046,065 bp from pter |
End:
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75,115,568 bp from pter |
Size:
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69,504 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 74,379,129-74,448,632 |
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Proteins
for POM121C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: P121C_HUMAN, A8CG34 (See
protein sequence)Recommended Name: Nuclear envelope pore membrane protein POM 121C Size: 1229 amino acids; 125059 Da
Subcellular location: Nucleus, nuclear pore complex. Nucleus membrane; Single-pass membrane protein. Endoplasmicreticulum membrane; Single-pass membrane protein (By similarity). Note=Stably associated with the NPC throughoutinterphase and the endoplasmic reticulum during metaphase (By similarity)
Secondary accessions: O75115 Q9Y2N3 Q9Y4S7Alternative splicing: 2 isoforms: A8CG34-1 A8CG34-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for POM121C: NX_A8CG34
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A8CG34
POM121C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001092885.1
ENSEMBL proteins: ENSP00000257665 ENSP00000414208 ENSP00000410033 ENSP00000381415
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
POM121C for ontologies About GeneDecksing
POM121C Antibody Products:
Assay Products for POM121C: |
Protein
Domains /
Families
for POM121C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
POM121C for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A8CG34ProtoNet protein and cluster: A8CG34 UniProtKB/Swiss-Prot: P121C_HUMAN, A8CG34Domain: Contains F-X-F-G repeatsSimilarity: Belongs to the POM121 family |
Function
for POM121C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: P121C_HUMAN, A8CG34Function: Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved inanchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation ofcytoplasmic annulate lamellae (AL)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POM121C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POM121C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: POM121C (NM_001099415) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POM121C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POM121C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POM121C |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
POM121C for ontologies About GeneDecksing
|
Pathways & Interactions
for POM121C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | RNA transport | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for POM121C):
POM121C for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POM121C
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/18 Interacting proteins for POM121C (A8CG343 ENSP000004142084) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0015031 | protein transport |
IEA | -- | | GO:0051028 | mRNA transport |
IEA | -- |
POM121C for ontologies About GeneDecksing
|
Drugs & Compounds
for POM121C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for POM121C
Search CenterWatch for drugs/clinical trials and news about POM121C / P121C
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Transcripts
for POM121C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for POM121C gene: NM_001099415.1 Unigene Cluster for POM121C: POM121 transmembrane nucleoporin C Hs.712563 [show with all ESTs]Unigene Representative Sequence: NM_0010994158 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000476072 ENST00000257665(uc010lde.1) ENST00000453279(uc003udk.4)
ENST00000473609 ENST00000473168 ENST00000439629 ENST00000479864 ENST00000398379(uc003udl.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POM121C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POM121C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: POM121C (NM_001099415) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POM121C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POM121C |
Additional cDNA sequence: AB354586.1 AK127026.1 AK293305.1 AK293781.1 AK311407.1 AL050158.1 BC013954.2 BC082993.1 BC130587.1 BC130589.1 BX649044.1 24/39 DOTS entries (see all 39): DT.100878800 DT.40108690 DT.40223154 DT.97862722 DT.121116955 DT.75157102 DT.95312575 DT.121116908 DT.121117133 DT.121116723 DT.121116879 DT.101979533 DT.121117114 DT.121116675 DT.40132467 DT.452605 DT.92469787 DT.100059442 DT.121090498 DT.121116880 DT.75102100 DT.92469777 DT.92469877 DT.95128557
GeneLoc Exon Structure
|
Expression
for POM121C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| POM121C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See POM121C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POM121C
SOURCE GeneReport for Unigene cluster: Hs.712563
SABiosciences Custom PCR Arrays for POM121C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POM121C
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat POM121C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POM121C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POM121C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POM121C |
Orthologs
for POM121C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for POM121C gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for POM121C (if available)
TreeFam Gene Tree for POM121C (if available) |
Paralogs
for POM121C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for POM121C gene
- POM1211 2 NUP1532 NUP2142 ENSG000001823562 POM121L72 POM121L1P2 POM121L4P2 POM121L22
18/269 SIMAP similar genes for POM121C using alignment to 4 protein entries: P121C_HUMAN (see all proteins)
(see all similar genes):PMS2P3 POMZP3 POM121B POM121 RBAK ZNF382
ZNF12 ZNF585A ZNF720 ZNF33B ZNF585B ZNF81
ZNF133 ZNF782 ZNF630 ZNF10 ZNF569 ZNF540
POM121C for paralogs About GeneDecksing
|
Genomic Variants
for POM121C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for POM121C (75046065 - 75115568 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for POM121C
5 CNVs: 3686 22956 4545 69960 94616
2 Indels: 33847 12936 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POM121C |
|
Disorders
/ Diseases
for POM121C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
POM121C for disorders About GeneDecksing
2  diseases for POM121C: About MalaCardswilliams-beuren syndrome williams syndrome
Export disorders for POM121C gene to outside databases
|
Publications
for POM121C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for POM121C gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with POM121C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes. (PubMed id 17900573)1, 2, 3 Funakoshi T....Imamoto N. (2007)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing. (PubMed id 17577209)1 Miele A....Stein J.L. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)
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External Searches for POM121C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing POM121C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing POM121C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing POM121C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for POM121C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for POM121C gene:
Search GeneIP for patents involving POM121C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for POM121C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for POM121C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POM121C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POM121C | | | OriGene Protein Over-expression Lysate for POM121C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for POM121C | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POM121C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POM121C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for POM121C | | OriGene Custom Protein Services for POM121C | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POM121C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POM121C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POM121C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POM121C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POM121C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POM121C |
| |
 |  |  |  | |
| | | | Search Tocris compounds for POM121C |
| |  |  |  |  | | | | |
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 | | | POM121C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POM121C |
|  |  |  | | | | Search ThermoFisher Antibodies for POM121C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POM121C |
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