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Aliases for POM121C Gene

Aliases for POM121C Gene

  • POM121 Transmembrane Nucleoporin C 2 3
  • Nuclear Pore Membrane Protein 121-2 3 4
  • Pore Membrane Protein Of 121 KDa C 3 4
  • POM121 Membrane Glycoprotein C 2 3
  • POM121-2 3 4
  • Nuclear Envelope Pore Membrane Protein POM 121C 3

External Ids for POM121C Gene

Summaries for POM121C Gene

GeneCards Summary for POM121C Gene

POM121C (POM121 Transmembrane Nucleoporin C) is a Protein Coding gene. Among its related pathways are RNA transport. An important paralog of this gene is POM121.

UniProtKB/Swiss-Prot for POM121C Gene

  • Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POM121C Gene

Genomics for POM121C Gene

Genomic Location for POM121C Gene

Start:
75,416,781 bp from pter
End:
75,486,288 bp from pter
Size:
69,508 bases
Orientation:
Minus strand

Genomic View for POM121C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POM121C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POM121C Gene

Regulatory Elements for POM121C Gene

Proteins for POM121C Gene

  • Protein details for POM121C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8CG34-P121C_HUMAN
    Recommended name:
    Nuclear envelope pore membrane protein POM 121C
    Protein Accession:
    A8CG34
    Secondary Accessions:
    • O75115
    • Q9Y2N3
    • Q9Y4S7

    Protein attributes for POM121C Gene

    Size:
    1229 amino acids
    Molecular mass:
    125059 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for POM121C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POM121C Gene

Proteomics data for POM121C Gene at MOPED

Post-translational modifications for POM121C Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys316, Lys364, and Lys405

Other Protein References for POM121C Gene

No data available for DME Specific Peptides for POM121C Gene

Domains for POM121C Gene

Protein Domains for POM121C Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

P121C_HUMAN
Domain:
  • Contains F-X-F-G repeats:
    • A8CG34
Family:
  • Belongs to the POM121 family.:
    • A8CG34
genes like me logo Genes that share domains with POM121C: view

No data available for Gene Families for POM121C Gene

Function for POM121C Gene

Molecular function for POM121C Gene

UniProtKB/Swiss-Prot Function: Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).

Gene Ontology (GO) - Molecular Function for POM121C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17577209
genes like me logo Genes that share ontologies with POM121C: view

miRNA for POM121C Gene

miRTarBase miRNAs that target POM121C

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for POM121C Gene

Localization for POM121C Gene

Subcellular locations from UniProtKB/Swiss-Prot for POM121C Gene

Nucleus, nuclear pore complex. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POM121C Gene COMPARTMENTS Subcellular localization image for POM121C gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for POM121C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005643 nuclear pore IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with POM121C: view

Pathways for POM121C Gene

SuperPathways for POM121C Gene

Superpath Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with POM121C: view

Pathways by source for POM121C Gene

1 KEGG pathway for POM121C Gene

Interacting Proteins for POM121C Gene

Selected Interacting proteins: A8CG34-P121C_HUMAN for POM121C Gene via I2D

Gene Ontology (GO) - Biological Process for POM121C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with POM121C: view

Transcripts for POM121C Gene

mRNA/cDNA for POM121C Gene

(2) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POM121C Gene

POM121 transmembrane nucleoporin C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POM121C Gene

No ASD Table

Relevant External Links for POM121C Gene

GeneLoc Exon Structure for
POM121C
ECgene alternative splicing isoforms for
POM121C

Expression for POM121C Gene

mRNA expression in normal human tissues for POM121C Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for POM121C Gene

SOURCE GeneReport for Unigene cluster for POM121C Gene Hs.712563

genes like me logo Genes that share expressions with POM121C: view

Orthologs for POM121C Gene

This gene was present in the common ancestor of chordates.

Orthologs for POM121C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POM121 36
  • 97.65 (n)
  • 95.91 (a)
cow
(Bos Taurus)
Mammalia POM121C 36
  • 79.09 (n)
  • 74.43 (a)
dog
(Canis familiaris)
Mammalia POM121C 36
  • 78.17 (n)
  • 73.95 (a)
mouse
(Mus musculus)
Mammalia Pom121 36
  • 74.63 (n)
  • 69.66 (a)
rat
(Rattus norvegicus)
Mammalia Pom121 36
  • 74.82 (n)
  • 69.09 (a)
chicken
(Gallus gallus)
Aves POM121 36
  • 59.74 (n)
  • 52.89 (a)
Species with no ortholog for POM121C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for POM121C Gene

ENSEMBL:
Gene Tree for POM121C (if available)
TreeFam:
Gene Tree for POM121C (if available)

Paralogs for POM121C Gene

Paralogs for POM121C Gene

Selected SIMAP similar genes for POM121C Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with POM121C: view

Variants for POM121C Gene

Sequence variations from dbSNP and Humsavar for POM121C Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs171040 -- 75,421,906(+) AAGGC(A/C/G)GAAGC reference, synonymous-codon
rs236607 -- 75,441,843(+) AGCTG(C/T)CTCAA intron-variant
rs236655 -- 75,418,889(+) GCCGC(C/T)GATCC synonymous-codon, reference
rs236656 -- 75,419,035(+) CACTG(G/T)ACGGG intron-variant
rs236657 -- 75,419,554(+) CCCCA(C/G)TTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POM121C Gene

Variant ID Type Subtype PubMed ID
nsv888381 CNV Gain 21882294
nsv528969 CNV Gain 19592680
dgv2102e1 CNV Complex 17122850
essv14753 CNV CNV 17122850
nsv831035 CNV Loss 17160897
nsv8156 CNV Loss 18304495
dgv120n16 CNV Deletion 17901297
nsv511367 CNV Loss 21212237
nsv365453 CNV Loss 16902084
esv21917 CNV Gain 19812545

Relevant External Links for POM121C Gene

HapMap Linkage Disequilibrium report
POM121C
Human Gene Mutation Database (HGMD)
POM121C

Disorders for POM121C Gene

No disorders were found for POM121C Gene.

No data available for UniProtKB/Swiss-Prot for POM121C Gene

Publications for POM121C Gene

  1. Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes. (PMID: 17900573) Funakoshi T. … Imamoto N. (FEBS Lett. 2007) 2 3 4
  2. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for POM121C Gene

Sources for POM121C Gene

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