Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



POLRMT Gene

protein-coding   GIFtS: 64
GCID: GC19M000617

Polymerase (RNA) Mitochondrial (DNA Directed)

  See POLRMT-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Polymerase (RNA) Mitochondrial (DNA Directed)1 2     MTRPOL2
EC 2.7.7.63 8     DNA-Directed RNA Polymerase, Mitochondrial2
APOLMT2 5     h-mtRPOL2
MTRNAP2     MtRPOL3

External Ids:    HGNC: 92001   Entrez Gene: 54422   Ensembl: ENSG000000998217   OMIM: 6017785   UniProtKB: O004113   

Export aliases for POLRMT gene to outside databases

Previous GC identifers: GC19M000669 GC19M000557 GC19M000568 GC19M000387


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for POLRMT Gene:
This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial
gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome.
Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more
closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. (provided by
RefSeq, Jul 2008)

GeneCards Summary for POLRMT Gene:
POLRMT (polymerase (RNA) mitochondrial (DNA directed)) is a protein-coding gene. Diseases associated with POLRMT include autosomal dominant progressive external ophthalmoplegia, and essential thrombocythemia. GO annotations related to this gene include DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot: RPOM_HUMAN, O00411
Function: DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four
ribonucleoside triphosphates as substrates

Gene Wiki entry for POLRMT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the POLRMT gene promoter:
         Lmo2   MyoD   POU3F2   AP-2gamma   E47   Egr-4   HEN1   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOLRMT promoter sequence
   Search Chromatin IP Primers for POLRMT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POLRMT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

POLRMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLRMT gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M000617:  view genomic region     (about GC identifiers)

Start:
617,223 bp from pter      End:
633,597 bp from pter
Size:
16,375 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RPOM_HUMAN, O00411 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase, mitochondrial precursor  
Size: 1230 amino acids; 138620 Da
Subunit: Interacts with TFB1M and TFB2M, leading to the stimulation of transcription. Interacts with TEFM
2 PDB 3D structures from and Proteopedia for POLRMT:
3SPA (3D)        4BOC (3D)    
Secondary accessions: O60370

Explore the universe of human proteins at neXtProt for POLRMT: NX_O00411

Explore proteomics data for POLRMT at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1197
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for POLRMT (O00411)
     VKQTVMT  PNFIHSLD  CNGLQHYAALG 


    See POLRMT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005026.3  
    ENSEMBL proteins: 
     ENSP00000465759   ENSP00000468658   ENSP00000466504   ENSP00000473524   ENSP00000475425  
    Reactome Protein details: O00411

    POLRMT Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for POLRMT
    OriGene Custom MassSpec
    OriGene Custom Protein Services for POLRMT
    GenScript Custom Purified and Recombinant Proteins Services for POLRMT
    Novus Biologicals POLRMT Proteins
    Novus Biologicals POLRMT Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for POLRMT

     
    Search eBioscience for Proteins for POLRMT 

     
    antibodies-online proteins for POLRMT (4 products) 

     
    Search antibodies-online for peptides for POLRMT

    POLRMT Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for POLRMT
    Novus Biologicals POLRMT Antibodies
    Abcam antibodies for POLRMT
    Cloud-Clone Corp. Antibodies for POLRMT
    ThermoFisher Antibody for POLRMT
    antibodies-online antibodies for POLRMT (14 products) 

    POLRMT Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for POLRMT
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for POLRMT
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for POLRMT
    Cloud-Clone Corp. CLIAs for POLRMT
    Search eBioscience for ELISAs for POLRMT 
    antibodies-online kits for POLRMT (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR024075 DNA-dir_RNA_pol_helix_hairpin
     IPR002092 DNA-dir_Rpol_phage-type

    Graphical View of Domain Structure for InterPro Entry O00411

    ProtoNet protein and cluster: O00411

    1 Blocks protein domain: IPB002092 DNA-directed RNA polymerase

    UniProtKB/Swiss-Prot: RPOM_HUMAN, O00411
    Similarity: Belongs to the phage and mitochondrial RNA polymerase family


    Find genes that share domains with POLRMT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPOM_HUMAN, O00411
    Function: DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four
    ribonucleoside triphosphates as substrates
    Catalytic activity: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

         Genatlas biochemistry entry for POLRMT:
    mitochondrial RNA polymerase

         Enzyme Number (IUBMB): EC 2.7.7.61 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003899DNA-directed RNA polymerase activity TAS17337445
    GO:0005515protein binding IPI17337445
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with POLRMT           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for POLRMT

    miRNA
    Products:
        
    miRTarBase miRNAs that target POLRMT:
    hsa-mir-30e-5p (MIRT044146), hsa-mir-30b-5p (MIRT046122), hsa-mir-1 (MIRT024018), hsa-mir-92a-3p (MIRT049050)

    Block miRNA regulation of human, mouse, rat POLRMT using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate POLRMT
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for POLRMT
    Predesigned siRNA for gene silencing in human, mouse, rat POLRMT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for POLRMT

    Clone
    Products:
         
    OriGene clones in human, mouse for POLRMT (see all 7)
    OriGene ORF clones in mouse, rat for POLRMT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POLRMT (NM_005035)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLRMT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLRMT

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for POLRMT
    Browse ESI BIO Cell Lines and PureStem Progenitors for POLRMT 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLRMT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RPOM_HUMAN, O00411: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA17337445
    GO:0005759mitochondrial matrix TAS--
    GO:0042645mitochondrial nucleoid IDA18063578

    Find genes that share ontologies with POLRMT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for POLRMT About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    Transcription from mitochondrial promoters0.00
    Mitochondrial transcription initiation0.00
    2Gene Expression
    Gene Expression0.40
    3Purine metabolism (KEGG)
    ATP ITP metabolism0.31
    4Mitochondrial Gene Expression
    Mitochondrial Gene Expression


    Find genes that share SuperPaths with POLRMT           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for POLRMT
        ATP/ITP metabolism

    1 BioSystems Pathway for POLRMT
        Mitochondrial Gene Expression

    2 Reactome Pathways for POLRMT
        Transcriptional activation of mitochondrial biogenesis
    Mitochondrial transcription initiation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POLRMT
    Interactions:

        GeneGlobe Interaction Network for POLRMT

    Selected Interacting proteins for POLRMT (O004112, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 250)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TFB1MQ8WVM02, 3MINT-8079030 I2D: score=3 
    NFKB2Q006532, 3MINT-48710 I2D: score=2 
    ICT1Q141972, 3MINT-8079030 I2D: score=1 
    KBTBD7Q8WVZ93I2D: score=3 
    MLH1P406923I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006390transcription from mitochondrial promoter TAS17337445
    GO:0006391transcription initiation from mitochondrial promoter TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with POLRMT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POLRMT (RPOM)

    7 HMDB Compounds for POLRMT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Thymidine 5'-triphosphate2'-Deoxythymidine 5'-triphosphate (see all 13)365-08-2--
    Uridine triphosphate5'-UTP (see all 7)63-39-8--

    1 Novoseek inferred chemical compound relationship for POLRMT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nucleoside 51.7 1 11526116 (1)



    Find genes that share compounds with POLRMT           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for POLRMT gene: 
    NM_005035.3  

    Unigene Cluster for POLRMT:

    Polymerase (RNA) mitochondrial (DNA directed)
    Hs.254113  [show with all ESTs]
    Unigene Representative Sequence: U75370
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588649 ENST00000592633 ENST00000587057 ENST00000589961 ENST00000590336
    ENST00000586384 ENST00000590709 ENST00000590573 ENST00000588630 ENST00000592863
    ENST00000607260
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat POLRMT using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate POLRMT
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for POLRMT
    Predesigned siRNA for gene silencing in human, mouse, rat POLRMT
    Clone
    Products:
         
    OriGene clones in human, mouse for POLRMT (see all 7)
    OriGene ORF clones in mouse, rat for POLRMT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POLRMT (NM_005035)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLRMT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLRMT
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for POLRMT
    OriGene qSTAR qPCR primer pairs in human, mouse for POLRMT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POLRMT
      QuantiTect SYBR Green Assays in human, mouse, rat POLRMT
      QuantiFast Probe-based Assays in human, mouse, rat POLRMT

    Additional mRNA sequence: 

    AB209920.1 AK225723.1 AK225865.1 AK302877.1 AK307525.1 BC024170.2 BC030829.1 BC070057.1 
    BC098387.1 U75370.1 

    9 DOTS entries:

    DT.413532  DT.102831307  DT.87016292  DT.100654690  DT.121434595  DT.102831308  DT.95073035  DT.95105973 
    DT.100812718 

    Selected AceView cDNA sequences (see all 188):

    AW298202 AW873537 AA316859 BM850929 AA715050 BU553405 AA550774 AA565330 
    BF434516 BF195560 BM683717 BM850744 BE675494 AW295276 BX362987 AW291590 
    AW293103 BM561590 BC070057 CD366855 AI743308 BQ187677 BQ063393 AA318636 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for POLRMT (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                      -                     
    SP3:                                                              -                                                                                             
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                      -                     

    ExUns: 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b · 23c
    SP1:                          -     -                                                   
    SP2:                          -     -                                                   
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for POLRMT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    POLRMT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCAGGTGT
    POLRMT Expression
    About this image


    POLRMT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    POLRMT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POLRMT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.254113
        Custom PCR Arrays for POLRMT
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for POLRMT
    OriGene qSTAR qPCR primer pairs in human, mouse for POLRMT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POLRMT
    QuantiTect SYBR Green Assays in human, mouse, rat POLRMT
    QuantiFast Probe-based Assays in human, mouse, rat POLRMT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLRMT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for POLRMT gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Polrmt1 , 5 polymerase (RNA) mitochondrial (DNA directed)1, 5 73.38(n)1
    68.59(a)1
      10 (39.72 cM)5
    2161511  NM_172551.31  NP_766139.21 
     797361235 
    chicken
    (Gallus gallus)
    Aves POLRMT1 polymerase (RNA) mitochondrial (DNA directed) 59.46(n)
    49.83(a)
      420084  XM_418204.4  XP_418204.3 
    lizard
    (Anolis carolinensis)
    Reptilia POLRMT6
    polymerase (RNA) mitochondrial (DNA directed)
    51(a)
    1 ↔ 1
    AAWZ02037496(3079-13398)
    African clawed frog
    (Xenopus laevis)
    Amphibia polrmt-A-prov2 polymerase (RNA) mitochondrial (DNA directed) 74.91(n)    AF200705.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb73g102 wufb73g10 75.11(n)   322808  57043062 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46443
    mtRNApol1
    DNA-directed RNA polymerase III3
    mitochondrial RNA polymerase1
    42(a)3
    54.31(n)1
    45.82(a)1
      332851  NM_001272924.11  NP_001259853.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y105E8A.233   -- 37(a)   I(14560229-14573885)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPO416
    Mitochondrial RNA polymerase; single subunit enzym...
    24(a)
    1 ↔ 1
    VI(58782-62837) YFL036W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SCA31 SCA3 48.01(n)
    43.4(a)
      816946  NM_127973.4  NP_179989.1 
    rice
    (Oryza sativa)
    Liliopsida Os.41482 O.sativa mRNA for putative T3/T7-like RNA polymerase, more 72.07(n)    AK069977.1 


    ENSEMBL Gene Tree for POLRMT (if available)
    TreeFam Gene Tree for POLRMT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for POLRMT gene

    Find genes that share paralogs with POLRMT           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for POLRMT
    PGOHUM00000237133 PGOHUM00000234186


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for POLRMT (see all 800)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1832469231,2
    C--617748(+) CATGGA/GTGGAC 1 -- int10--------
    rs1423572821,2
    C--617749(+) ATGGGG/TGGACT 1 -- int10--------
    rs415542121,2
    C,F--617769(-) GCCCCC/TGTAGT 1 -- int12Minor allele frequency- T:0.00NA EU 1325
    rs2004605411,2
    --617792(+) ACGGAA/GACATC 2 V syn10--------
    rs1442816681,2
    F--617804(+) GCTGCG/ATGAGT 2 /H syn11Minor allele frequency- A:0.00NA 4518
    rs2002248601,2
    F--617813(+) GTCCAA/C/GTAACA 3 Y * stg1 syn11EU 1324
    rs1463553921,2
    C--617822(+) CAGTCA/GTGCAC 2 H syn10--------
    rs759131431,2
    C,F--617837(+) ACGAAA/G/TGTCAG 3 T syn12NA EU 5833
    rs2015582721,2
    C--617838(+) CGAAGG/ATCAGG 2 /T /I mis11Minor allele frequency- A:0.00EU 1315
    rs2002496971,2
    C--617861(+) CAGAGC/TGGAGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for POLRMT (617223 - 633597 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for POLRMT (see all 37):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717756CNV Deletion23290073
    nsv910233CNV Loss21882294
    nsv910235CNV Loss21882294
    dgv3528n71CNV Loss21882294
    dgv3515n71CNV Loss21882294
    dgv3527n71CNV Loss21882294
    dgv3539n71CNV Loss21882294
    nsv910109CNV Loss21882294
    nsv910102CNV Loss21882294
    dgv3516n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): POLRMT
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POLRMT
    DNA2.0 Custom Variant and Variant Library Synthesis for POLRMT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601778    OMIM disorders: --

    2 diseases for POLRMT:    
    About MalaCards
    autosomal dominant progressive external ophthalmoplegia    essential thrombocythemia


    Find genes that share disorders with POLRMT           About GenesLikeMe

    1 Novoseek inferred disease relationship for POLRMT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aids 0.742 1 11526116 (1)

    Genetic Association Database (GAD): POLRMT
    Human Genome Epidemiology (HuGE) Navigator: POLRMT (2 documents)

    Export disorders for POLRMT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for POLRMT gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with POLRMT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the gene encoding the human mitochondrial RNA polymerase (h-mtRPOL) by cyberscreening of the Expressed Sequence Tags database. (PubMed id 9097968)1, 2, 3 Tiranti V....Zeviani M. (Hum. Mol. Genet. 1997)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (Carcinogenesis 2009)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    5. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. (PubMed id 12068295)1, 2 Falkenberg M....Gustafsson C.M. (Nat. Genet. 2002)
    6. Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression. (PubMed id 17337445)1, 9 Wang Z....Shadel G.S. (J. Biol. Chem. 2007)
    7. DNA conformation-dependent activities of human mitochondrial RNA polymerase. (PubMed id 19624753)1, 9 Fukuoh A....Kang D. (amp 2009)
    8. The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells. (PubMed id 15526033)1, 9 Gaspari M.... Gustafsson C.M. (EMBO J. 2004)
    9. Transcription of mammalian messenger RNAs by a nuclear RNA polymerase of mitochondrial origin. (PubMed id 16079853)1, 9 Kravchenko J.E....Chumakov P.M. (Nature 2005)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5442 HGNC: 9200 AceView: POLRMT Ensembl:ENSG00000099821 euGenes: HUgn5442
    ECgene: POLRMT H-InvDB: POLRMT

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for POLRMT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for POLRMT gene:
    Search GeneIP for patents involving POLRMT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for POLRMT  
     OriGene qPCR primer pairs and template standards for POLRMT   OriGene Protein Over-expression Lysate for POLRMT  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for POLRMT  
     OriGene qSTAR qPCR primer pairs in human, mouse for POLRMT   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for POLRMT   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for POLRMT   OriGene Custom Protein Services for POLRMT  

     
     
     Block miRNA regulation of human, mouse, rat POLRMT using miScript Target Protectors SeqTarget long-range PCR primers for resequencing POLRMT
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POLRMT Predesigned siRNA for gene silencing in human, mouse, rat POLRMT
     QuantiFast Probe-based Assays in human, mouse, rat POLRMT QuantiTect SYBR Green Assays in human, mouse, rat POLRMT
     Custom PCR Arrays for POLRMT Search Chromatin IP Primers for POLRMT
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POLRMT  GeneGlobe Interaction Network for POLRMT
     Regulatory tfbs in POLRMT promoter
     GenScript Custom Purified and Recombinant Proteins Services for POLRMT GenScript cDNA clones with any tag delivered in your preferred vector for POLRMT
     GenScript Custom Assay Services for POLRMT GenScript Custom overexpressing Cell Line Services for POLRMT
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for POLRMT (RPOM)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     POLRMT antibodies
     POLRMT proteins
     POLRMT lysates
     Antibodies for POLRMT
     See all of Abcam's Antibodies, Kits and Proteins for POLRMT
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for POLRMT
     Antibodies for POLRMT
     ELISAs for POLRMT
     CLIAs for POLRMT



     Browse ESI BIO Cell Lines and PureStem Progenitors for POLRMT
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLRMT
     Browse SwitchGear 3'UTR luciferase reporter plasmids for POLRMT
     SwitchGear Promoter luciferase reporter plasmids for POLRMT
     ThermoFisher Antibody for POLRMT
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLRMT
     Browse compounds at ApexBio
     Search Addgene for plasmids for POLRMT
      Search eBioscience for proteins for POLRMT
      Search eBioscience for elisas for POLRMT
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for POLRMT
     antibodies-online antibodies for POLRMT (14 products)
     antibodies-online kits for POLRMT (2 products)
      Search antibodies-online for peptides for POLRMT
     antibodies-online proteins for POLRMT (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      POLRMT gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4