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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POLR3K Gene

protein-coding   GIFtS: 58
GCID: GC16M000096

Polymerase (RNA) III (DNA Directed) Polypeptide K, 12.3...

(Previous name: polymerase (RNA) III (DNA directed) polypeptide K (12.3...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Polymerase (RNA) III (DNA Directed) Polypeptide K, 12.3 KDa1 2     C112
RPC112 3     C11-RNP32
RPC12.52 3     RPC102
DNA-Directed RNA Polymerase III Subunit K2 3     DNA-Directed RNA Polymerase III Subunit RPC102
hRPC112 3     DNA-Directed RNA Polymerases III 12.5 KDa Polypeptide2
RNA Polymerase III 12.5 KDa Subunit2 3     RNA Polymerase III Subunit (HRPC11)2
RNA Polymerase III Subunit C102 3     RNA Polymerase III Subunit CII2
RNA Polymerase III Subunit C112 3     HsC11p3
Polymerase (RNA) III (DNA Directed) Polypeptide K (12.3 KDa)1     

External Ids:    HGNC: 141211   Entrez Gene: 517282   Ensembl: ENSG000001619807   OMIM: 6060075   UniProtKB: Q9Y2Y13   

Export aliases for POLR3K gene to outside databases

Previous GC identifers: GC16M000115 GC16M000036 GC16M000015


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POLR3K Gene:
This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing
transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree
of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity
in sequence is supported by functional studies showing that this subunit is required for proper pausing and
termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17.(provided by
RefSeq, Jul 2010)

GeneCards Summary for POLR3K Gene: 
POLR3K (polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa) is a protein-coding gene. Diseases associated with POLR3K include rheumatic disease, and herpes simplex, and among its related super-pathways are RNA Polymerase III Transcription Initiation and Purine metabolism. GO annotations related to this gene include DNA-directed RNA polymerase activity and DNA binding.

UniProtKB/Swiss-Prot: RPC10_HUMAN, Q9Y2Y1
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and
tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as
nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as
template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr
virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity)

Gene Wiki entry for POLR3K Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POLR3K gene promoter:
         E2F-4   E2F-3a   E2F-1   E2F   p53   E2F-2   AP-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOLR3K promoter sequence
   Search SABiosciences Chromatin IP Primers for POLR3K

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLR3K


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

POLR3K Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR3K gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M000096:  view genomic region     (about GC identifiers)

Start:
96,407 bp from pter      End:
103,632 bp from pter
Size:
7,226 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RPC10_HUMAN, Q9Y2Y1 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase III subunit RPC10  
Size: 108 amino acids; 12336 Da
Subunit: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q1W6H4 Q96S35

Explore the universe of human proteins at neXtProt for POLR3K: NX_Q9Y2Y1

Explore proteomics data for POLR3K at MOPED 

POLR3K Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

POLR3K Protein Expression

REFSEQ proteins: NP_057394.2  
ENSEMBL proteins: 
 ENSP00000293860  
Reactome Protein details: Q9Y2Y1
Human Recombinant Protein Products for POLR3K: 
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OriGene Protein Over-expression Lysate for POLR3K
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Novus Biologicals POLR3K Protein
Novus Biologicals POLR3K Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for POLR3K 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005654nucleoplasm TAS--
GO:0005666DNA-directed RNA polymerase III complex TAS9869639
GO:0005829cytosol TAS--

POLR3K for ontologies           About GeneDecksing



POLR3K Antibody Products: 
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Abcam antibodies for POLR3K
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LSBio Antibodies in human, mouse, rat for POLR3K 

Assay Products for POLR3K: 
Browse Kits and Assays available from EMD Millipore
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GenScript Custom Assay Services for POLR3K
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for POLR3K 
Cloud-Clone Corp. CLIAs for POLR3K


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
POLR: RNA polymerase subunits

4 InterPro protein domains:
 IPR001222 Znf_TFIIS
 IPR001529 DNA-dir_RNA_pol_M/15kDasu
 IPR012164 DNA-dir_RNApol_C11
 IPR019761 DNA-dir_RNA_pol-M_15_CS

Graphical View of Domain Structure for InterPro Entry Q9Y2Y1

ProtoNet protein and cluster: Q9Y2Y1

1 Blocks protein domain: IPB001529 DNA-directed RNA polymerase

UniProtKB/Swiss-Prot: RPC10_HUMAN, Q9Y2Y1
Similarity: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family
Similarity: Contains 1 TFIIS-type zinc finger


POLR3K for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: RPC10_HUMAN, Q9Y2Y1
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and
tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as
nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as
template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr
virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity)

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0003899DNA-directed RNA polymerase activity IEA--
GO:0008270zinc ion binding IEA--
     
POLR3K for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for POLR3K:
 Increased gamma-H2AX phosphory 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for POLR3K 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POLR3K

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POLR3K 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POLR3K 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLR3K
2 QIAGEN miScript miRNA Assays for microRNAs that regulate POLR3K:
hsa-miR-1207-3p hsa-miR-378*
SwitchGear 3'UTR luciferase reporter plasmidPOLR3K 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for POLR3K
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Gene Editing
Products:
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Sirion Biotech Customized adenovirus for overexpression of POLR3K

Clone
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OriGene ORF clones in mouse, rat for POLR3K
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: POLR3K (NM_016310)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLR3K
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR3K
Sirion Biotech Customized lentivirus for stable overexpression of POLR3K 
                     Customized lentivirus expression plasmids for stable overexpression of POLR3K 

Cell Line
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GenScript Custom overexpressing Cell Line Services for POLR3K
Search LifeMap BioReagents cell lines for POLR3K
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR3K


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for POLR3K About   (see all 11)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1RNA Polymerase III Transcription Initiation
RNA Polymerase III Transcription Initiation0.80
RNA Polymerase III Transcription Initiation From Type 2 Promoter0.74
RNA Polymerase III Transcription0.80
RNA Polymerase III Chain Elongation0.69
RNA Polymerase III Abortive And Retractive Initiation0.80
RNA Polymerase III Transcription Termination0.69
RNA Polymerase III Transcription Initiation From Type 3 Promoter0.80
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.59
2Purine metabolism
Purine metabolism0.38
ATP/ITP metabolism0.31
Pyrimidine metabolism0.38
3Cytosolic DNA-sensing pathway
Cytosolic DNA-sensing pathway0.36
Cytosolic sensors of pathogen-associated DNA 0.36
4Assembly of RNA Polymerase-III Initiation Complex
Assembly of RNA Polymerase-III Initiation Complex0.83
Transcription of tRNA0.83
5Immune System
Immune System0.56
Innate Immune System0.50

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for POLR3K
    ATP/ITP metabolism

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POLR3K
    DNA Repair Mechanisms
Transcription of tRNA
Assembly of RNA Polymerase-III Initiation Complex

1 GeneGo (Thomson Reuters) Pathway for POLR3K
    ATP/ITP metabolism

1 BioSystems Pathway for POLR3K
    Eukaryotic Transcription Initiation

5/14        Reactome Pathways for POLR3K (see all 14)
    RNA Polymerase III Transcription Initiation
RNA Polymerase III Transcription Initiation From Type 3 Promoter
Cytosolic sensors of pathogen-associated DNA
RNA Polymerase III Chain Elongation
Transcription


5/6         Kegg Pathways  (Kegg details for POLR3K) (see all 6):
    Purine metabolism
Pyrimidine metabolism
Metabolic pathways
RNA polymerase
Cytosolic DNA-sensing pathway


POLR3K for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POLR3K

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/107 Interacting proteins for POLR3K (Q9Y2Y13 ENSP000002938604) via UniProtKB, MINT, STRING, and/or I2D (see all 107)
InteractantInteraction Details
GeneCardExternal ID(s)
POLR3AO148023, ENSP000003614464I2D: score=4 STRING: ENSP00000361446
POLR1DQ9Y2S03, ENSP000003024784I2D: score=2 STRING: ENSP00000302478
POLR2EP193883, ENSP000002155874I2D: score=2 STRING: ENSP00000215587
TADA2AO754783, ENSP000002253964I2D: score=2 STRING: ENSP00000225396
FEN1P397483, ENSP000003054804I2D: score=1 STRING: ENSP00000305480
About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-dependent ----
GO:0006383transcription from RNA polymerase III promoter TAS--
GO:0006385transcription elongation from RNA polymerase III promoter TAS--
GO:0006386termination of RNA polymerase III transcription TAS--
GO:0010467gene expression TAS--

POLR3K for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

POLR3K for compounds           About GeneDecksing

EMD Millipore small molecules for POLR3K:
Small Molecule - inhibitor
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for POLR3K (RPC10)

6 HMDB Compounds for POLR3K    About this table
CompoundSynonyms CAS #PubMed Ids
Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
Guanosine triphosphate5'-GTP (see all 10)86-01-1--
Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
Uridine triphosphate5'-UTP (see all 7)63-39-8--

10/19 Novoseek inferred chemical compound relationships for POLR3K gene (see all 19)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
s-napc 79.9 4 17670747 (1), 15469824 (1), 16901896 (1), 8339931 (1)
alpha-amanitin 76.7 10 10702296 (1), 7493976 (1), 9331371 (1), 2299673 (1) (see all 8)
phosphocellulose 66.1 3 8647083 (1), 1454534 (1)
tagetitoxin 64.8 2 10702296 (1), 7479000 (1)
trna 62.2 5 18987635 (1), 19450263 (1), 8164661 (1), 8063824 (1) (see all 5)
trna(val) 57.3 2 17634584 (1)
poly u 31.8 1 11342556 (1)
rrna 22.6 1 2043343 (1)
adenylate 21.8 4 12815945 (1), 14565867 (1), 7929274 (1)
doxycycline 20 1 12776180 (1)

Search CenterWatch for drugs/clinical trials and news about POLR3K / RPC10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for POLR3K gene: 
NM_016310.3  

Unigene Cluster for POLR3K:

Polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
Hs.632223  [show with all ESTs]
Unigene Representative Sequence: BF683481
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000293860(uc002cfi.2) ENST00000481810
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
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2 QIAGEN miScript miRNA Assays for microRNAs that regulate POLR3K:
hsa-miR-1207-3p hsa-miR-378*
SwitchGear 3'UTR luciferase reporter plasmidPOLR3K 3' UTR sequence
Inhib. RNA
Products:
     
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OriGene RNAi products in human, mouse, rat for POLR3K
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Clone
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OriGene ORF clones in mouse, rat for POLR3K
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: POLR3K (NM_016310)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLR3K
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR3K
Sirion Biotech Customized lentivirus for stable overexpression of POLR3K 
                     Customized lentivirus expression plasmids for stable overexpression of POLR3K 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for POLR3K
OriGene qSTAR qPCR primer pairs in human, mouse for POLR3K
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POLR3K
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR3K
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR3K

Additional mRNA sequence: 

AF051316.1 BC011932.2 DQ655978.2 

4 DOTS entries:

DT.111707  DT.100777664  DT.75147673  DT.120670942 

24/107 AceView cDNA sequences (see all 107):

CB243421 AW275005 BU167160 AW167513 AW138186 BU738967 AI858883 AA827399 
BQ021779 BQ001524 AI368581 BU742106 BQ637664 BE297777 AI224102 AI913788 
BM770107 BM771187 BM887722 BE549250 CD643454 AA773182 BE269869 BM805261 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

POLR3K expression in normal human tissues (normalized intensities)      POLR3K embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCCCTAAATA
POLR3K Expression
About this image


POLR3K expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Cerebral Cortex
         brain/forebrain/telencephalon   
 
 Eye (Sensory Organs)
         Retina
 
 Neural Tube (Nervous System)
         Telencephalon

 -- (Nervous System)
         mouse/organ system/nervous system/central nervous system   

See POLR3K Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POLR3K

SOURCE GeneReport for Unigene cluster: Hs.632223
    SABiosciences Custom PCR Arrays for POLR3K
Primer
Products:
OriGene qPCR primer pairs and template standards for POLR3K
OriGene qSTAR qPCR primer pairs in human, mouse for POLR3K
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POLR3K
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR3K
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR3K
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR3K

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR3K gene from 10/22 species (see all 22)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Polr3k1 , 5 polymerase (RNA) III (DNA directed) polypeptide K1, 5 89.2(n)1
98.15(a)1
  2 (103.82 cM)5
670051  NM_025901.31  NP_080177.11 
 1818643375 
chicken
(Gallus gallus)
Aves POLR3K1 polymerase (RNA) III (DNA directed) polypeptide K, more 77.16(n)
87.04(a)
  768505  XM_001231485.2  XP_001231486.2 
lizard
(Anolis carolinensis)
Reptilia POLR3K6
Uncharacterized protein
83(a)
1 ↔ 1
GL343856.1(158197-158486)
African clawed frog
(Xenopus laevis)
Amphibia MGC685822 DNA-directed RNA polymerases III 12.5 kDa polypeptide 79.33(n)    BC061683.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.249922 Transcribed sequence with strong similarity to protein more 77.25(n)    57039718 
fruit fly
(Drosophila melanogaster)
Insecta CG337856
--
70(a)
1 ↔ 1
2R(16529971-16531310)
worm
(Caenorhabditis elegans)
Secernentea Y77E11A.61 , 3 Protein Y77E11A.61 61(a)3
62.35(n)1
62.04(a)1
  IV(1408712-1410042)3
1769501  NM_067675.21  NP_500076.11 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPC11(YDR045C)4
RPC111
RNA polymerase III subunit C11; mediates pol III RNA more4
Rpc11p1
55.77(n)1
55.77(a)1
  4(548310-547978)4
8516151, 4  NP_010330.11, 4 
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G079501 DNA-directed RNA polymerase, subunit M 53.06(n)
47.96(a)
  826299  NM_116865.2  NP_192535.1 
rice
(Oryza sativa)
Liliopsida Os02g06727001 hypothetical protein 56.19(n)
43.81(a)
  4330285  NM_001054243.1  NP_001047708.1 


ENSEMBL Gene Tree for POLR3K (if available)
TreeFam Gene Tree for POLR3K (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for POLR3K gene

POLR3K for paralogs           About GeneDecksing


4 Pseudogenes.org Pseudogenes for POLR3K
PGOHUM00000248413 PGOHUM00000237174 PGOHUM00000234833 PGOHUM00000236795


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/133 SNPs in POLR3K are shown (see all 133)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0279184
----see VAR_0279182 S A mis40--------
rs570903471,2
C,F--96496(+) GAGGCA/GGACAG 1 -- ds50012Minor allele frequency- G:0.12WA NA 122
rs572966611,2
C,F--96650(+) ACCCGC/GAAGGC 1 -- ds50011Minor allele frequency- G:0.00WA 2
rs1862745621,2
--96733(+) AAATAA/CATAAA 1 -- ds50010--------
rs611300681,2
C--96744(+) TAAAT-/AAAATA 1 -- ds50010--------
rs1449632841,2
C--96744(+) AAATA-/AATAAATA 1 -- cds10--------
rs563315261,2
C--96746(+) ATAAA-/TAAATAAA 1 -- cds10--------
rs1895637001,2
--96854(+) AGAAAG/TAAATT 1 -- ds50010--------
rs1418896951,2
C--96930(+) ACTGTA/GATTTG 1 -- ds50010--------
rs1460921791,2
C--96973(+) ACACTA/GAGAAG 1 -- ds50010--------

HapMap Linkage Disequilibrium report for POLR3K (96407 - 103632 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for POLR3K:    About this table     
Variant IDTypeSubtypePubMed ID
esv2422427CNV Duplication17116639
nsv522688CNV Loss19592680
nsv518291CNV Loss19592680
dgv2456n71CNV Loss21882294
dgv2455n71CNV Loss21882294
nsv904623CNV Gain+Loss21882294
dgv789e1CNV Complex17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 606007    OMIM disorders: --

11 diseases for POLR3K:    About MalaCards
rheumatic disease    herpes simplex    scleroderma    sjogren's syndrome
retinoblastoma    lupus erythematosus    systemic lupus erythematosus    microphthalmia
hepatitis b    hepatitis    neuronitis


POLR3K for disorders           About GeneDecksing

10/18 Novoseek inferred disease relationships for POLR3K gene (see all 18)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
renal scleroderma 68.4 1 20439528 (1)
sclerosis systemic 34.4 6 12384934 (2), 17610318 (1), 8214977 (1), 17631732 (1) (see all 5)
retinoblastoma 29.5 6 15199152 (2), 11094071 (1), 9169441 (1), 10330166 (1) (see all 5)
lupus erythematosus systemic 20.9 1 8035794 (1)
sjogrens syndrome 16 1 8035794 (1)
rheumatic diseases 11.3 2 10564276 (1), 16387655 (1)
tumors 4.67 5 15798209 (1), 16210911 (1), 11097422 (1), 15199152 (1) (see all 5)
carcinoma embryonal 3.77 1 9642284 (1)
carcinoma 3.31 2 1700854 (1), 1710020 (1)
immunodeficiency 0.524 2 9261187 (1), 8683593 (1)


Export disorders for POLR3K gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for POLR3K gene, integrated from 9 sources (see all 235):
(articles sorted by number of sources associating them with POLR3K)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular identification and characteristics of hRPC11, the smallest specific subunit of human RNA polymerase III. (PubMed id 10079944)1, 2, 3, 9 Spakovskii G.V. and Lebedenko E.N. (1998)
  2. The RNA cleavage activity of RNA polymerase III is mediated by an essential TFIIS-like subunit and is important for transcription termination. (PubMed id 9869639)1, 2, 3 Chedin S.... Carles C. (1998)
  3. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PubMed id 12391170)1, 2, 9 Hu P....Hernandez N. (2002)
  4. A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter. (PubMed id 16728641)1, 2 De Gobbi M.... Higgs D.R. (2006)
  5. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  7. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
  8. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. (PubMed id 19609254)2, 9 Ablasser A....Hornung V. (2009)
  9. Genome-wide association analysis of red blood cell tra its in African Americans: the COGENT Network. (PubMed id 23446634)1 Chen Z....Reiner A.P. (2013)
  10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
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OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 51728 HGNC: 14121 AceView: POLR3K Ensembl:ENSG00000161980 euGenes: HUgn51728
ECgene: POLR3K Kegg: 51728 H-InvDB: POLR3K

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for POLR3K Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for POLR3K gene:
Search GeneIP for patents involving POLR3K

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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