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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

POLR3K Gene

protein-coding GIFtS: 55
GCID: GC16M000096

polymerase (RNA) III (DNA directed) polypeptide K, 12.3...

(Previous name: polymerase (RNA) III (DNA directed) polypeptide K (12.3...)

Explore 17 diseases affiliated with
POLR3K via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Polymerase (RNA) III (DNA Directed) Polypeptide K, 12.3 KDa¹ ²		C11²
RPC11¹ ² ³		C11-RNP3²
RPC12.5² ³		RPC10²
DNA-Directed RNA Polymerase III Subunit K² ³		DNA-Directed RNA Polymerase III Subunit RPC10²
HRPC11¹		DNA-Directed RNA Polymerases III 12.5 KDa Polypeptide²
RNA Polymerase III 12.5 KDa Subunit² ³		RNA Polymerase III Subunit (HRPC11)²
RNA Polymerase III Subunit C10² ³		RNA Polymerase III Subunit CII²
RNA Polymerase III Subunit C11² ³		HsC11p³
Polymerase (RNA) III (DNA Directed) Polypeptide K (12.3 KDa)¹

External Ids:	HGNC: 14121¹	Entrez Gene: 51728²	Ensembl: ENSG00000161980⁷	OMIM: 606007⁵	UniProtKB: Q9Y2Y1³

Export aliases for POLR3K gene to outside databases

Previous GC identifers: GC16M000115 GC16M000036 GC16M000015

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POLR3K:

This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer

and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence

similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is

supported by functional studies showing that this subunit is required for proper pausing and termination during

transcription. Pseudogenes of this gene are found on chromosomes 13 and 17.(provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: RPC10_HUMAN, Q9Y2Y1

Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside

triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.

Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and

cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for

transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs)

induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity)

Gene Wiki entry for POLR3K

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the POLR3K gene promoter:
E2F-4 E2F-3a E2F-1 E2F p53 E2F-2 AP-4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: POLR3K promoter sequence

Search SABiosciences Chromatin IP Primers for POLR3K

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLR3K

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

POLR3K Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR3K gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M000096: view genomic region (about GC identifiers)

Start:	96,407 bp from pter	End:	103,632 bp from pter
Size:	7,226 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RPC10_HUMAN, Q9Y2Y1 (See protein sequence)

Recommended Name: DNA-directed RNA polymerase III subunit RPC10

Size: 108 amino acids; 12336 Da

Subunit: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity)

Subcellular location: Nucleus (By similarity)

Secondary accessions: Q1W6H4 Q96S35

Explore the universe of human proteins at neXtProt for POLR3K: NX_Q9Y2Y1

POLR3K Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_057394.2

ENSEMBL proteins:

ENSP00000293860

Reactome Protein details: Q9Y2Y1
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	OriGene Purified Protein: POLR3K OriGene Protein Over-expression Lysate: POLR3K OriGene Custom Protein Services for POLR3K
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	Novus Biologicals POLR3K Protein Novus Biologicals POLR3K Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for POLR3K

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--
GO:0005666	DNA-directed RNA polymerase III complex	TAS	9869639

POLR3K for ontologies About GeneDecksing

POLR3K Antibody Products:

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	Novus Biologicals POLR3K Antibodies
	Search for Antibodies for POLR3K at Abcam
	Uscn Antibodies for POLR3K
	Search ThermoFisher Antibodies for POLR3K

Assay Products for POLR3K:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for POLR3K
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for POLR3K

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

POLR3K for domains About GeneDecksing

4 InterPro domains/families:

IPR001222 Znf_TFIIS

IPR001529 DNA-dir_RNA_pol_M/15kDasu

IPR012164 DNA-dir_RNApol_C11

IPR019761 DNA-dir_RNA_pol-M_15_CS

Graphical View of Domain Structure for InterPro Entry Q9Y2Y1

ProtoNet protein and cluster: Q9Y2Y1

1 Blocks protein family: IPB001529 DNA-directed RNA polymerase

UniProtKB/Swiss-Prot: RPC10_HUMAN, Q9Y2Y1

Similarity: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family

Similarity: Contains 1 TFIIS-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RPC10_HUMAN, Q9Y2Y1

Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside

triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.

Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and

cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for

transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs)

induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: POLR3K Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLR3K
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate POLR3K:
		hsa-miR-1207-3p hsa-miR-378*
		SwitchGear 3'UTR luciferase reporter plasmid: POLR3K 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLR3K (see all 7) OriGene shRNA RFP: POLR3K OriGene siRNA: POLR3K
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLR3K

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for POLR3K

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLR3K (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLR3K OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for POLR3K
		Search LifeMap BioReagents cell lines for POLR3K

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for POLR3K

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003899	DNA-directed RNA polymerase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--

POLR3K for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for POLR3K:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

RNA Polymerase III Transcription Initiation

8/10 pathways (see all 10)
RNA Polymerase III Transcription Initiation	1.00	RNA Polymerase III Transcription Initiation From Type 2 Promoter	0.74
RNA Polymerase III Abortive And Retractive Initiation	1.00	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	0.59
RNA Polymerase III Transcription	1.00	RNA Polymerase III Chain Elongation	0.51
RNA Polymerase III Transcription Initiation From Type 3 Promoter	0.80	RNA Polymerase III Transcription Termination	0.51

ATP/ITP metabolism

ATP/ITP metabolism

1.00

ATP/ITP metabolism

0.98

Assembly of RNA Polymerase-III Initiation Complex

Assembly of RNA Polymerase-III Initiation Complex

1.00

Transcription of tRNA

0.83

Purine metabolism

Purine metabolism

1.00

Pyrimidine metabolism

0.38

Transcription

Transcription

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for POLR3K

ATP/ITP metabolism

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POLR3K

	DNA Repair Mechanisms
	Transcription of tRNA
	Assembly of RNA Polymerase-III Initiation Complex

1 GeneGo (Thomson Reuters) Pathway for POLR3K

ATP/ITP metabolism

1 BioSystems Pathway for POLR3K

Eukaryotic Transcription Initiation

5/11 Reactome Pathways for POLR3K (see all 11)

	RNA Polymerase III Transcription Initiation
	RNA Polymerase III Transcription Initiation From Type 3 Promoter
	RNA Polymerase III Chain Elongation
	Transcription
	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription

5 Kegg Pathways (Kegg details for POLR3K):

	Purine metabolism
	Pyrimidine metabolism
	Metabolic pathways
	RNA polymerase
	Cytosolic DNA-sensing pathway

POLR3K for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for POLR3K

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/107 Interacting proteins for POLR3K (Q9Y2Y1³ ENSP00000293860⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 107)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
POLR3A	O14802³, ENSP00000361446⁴	I2D: score=4 STRING: ENSP00000361446
POLR1D	Q9Y2S0³, ENSP00000302478⁴	I2D: score=2 STRING: ENSP00000302478
POLR2E	P19388³, ENSP00000215587⁴	I2D: score=2 STRING: ENSP00000215587
TADA2A	O75478³, ENSP00000225396⁴	I2D: score=2 STRING: ENSP00000225396
FEN1	P39748³, ENSP00000305480⁴	I2D: score=1 STRING: ENSP00000305480

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006383	transcription from RNA polymerase III promoter	TAS	--
GO:0006385	transcription elongation from RNA polymerase III promoter	TAS	--
GO:0006386	termination of RNA polymerase III transcription	TAS	--
GO:0009615	response to virus	--	--
GO:0010467	gene expression	TAS	--

POLR3K for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

POLR3K for compounds About GeneDecksing

EMD Millipore small molecules for POLR3K:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for POLR3K

6 HMDB Compounds for POLR3K About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Cytidine triphosphate	cytidine 5'-(tetrahydrogen triphosphate) (see all 15)	65-47-4	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--
Uridine triphosphate	5'-UTP (see all 7)	63-39-8	--

10/19 Novoseek chemical compound relationships for POLR3K gene (see all 19) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
s-napc	79.9	4	17670747 (1), 15469824 (1), 16901896 (1), 8339931 (1)
alpha-amanitin	76.7	10	10702296 (1), 7493976 (1), 9331371 (1), 2299673 (1) (see all 8)
phosphocellulose	66.1	3	8647083 (1), 1454534 (1)
tagetitoxin	64.8	2	10702296 (1), 7479000 (1)
trna	62.2	5	18987635 (1), 19450263 (1), 8164661 (1), 8063824 (1) (see all 5)
trna(val)	57.3	2	17634584 (1)
poly u	31.8	1	11342556 (1)
rrna	22.6	1	2043343 (1)
adenylate	21.8	4	12815945 (1), 14565867 (1), 7929274 (1)
doxycycline	20	1	12776180 (1)

Search CenterWatch for drugs/clinical trials and news about POLR3K / RPC10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for POLR3K gene:

NM_016310.3

Unigene Cluster for POLR3K:

Polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa

Hs.632223 [show with all ESTs]

Unigene Representative Sequence: BF683481

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000293860(uc002cfi.2) ENST00000481810

miRNA Products:		OriGene 3'-UTR Clone: POLR3K Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLR3K
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate POLR3K:
		hsa-miR-1207-3p hsa-miR-378*
		SwitchGear 3'UTR luciferase reporter plasmid: POLR3K 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLR3K (see all 7) OriGene shRNA RFP: POLR3K OriGene siRNA: POLR3K
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLR3K

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLR3K (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLR3K OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: POLR3K (NM_016310)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLR3K
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR3K

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLR3K Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR3K
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR3K

Additional cDNA sequence:

AF051316.1 BC011932.2 DQ655978.2

4 DOTS entries:

DT.111707 DT.100777664 DT.75147673 DT.120670942

24/107 AceView cDNA sequences (see all 107):

CB243421 BU742106 BU738967 AA827399 AW275005 AI858883 AW138186 AW167513

BU167160 AI368581 BQ021779 BQ001524 AW675452 BE549250 CB241037 BX281106

BG167906 BM771224 AI313394 BM751878 BQ637664 BE538674 BQ027430 BM771370

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

POLR3K expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCCTAAATA

About this image

POLR3K expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Hyoid Arch Muscles

Mononuclear Myocytes

Skeletal Muscle

Mandibular Arch Muscles

Mononuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See POLR3K Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POLR3K

SOURCE GeneReport for Unigene cluster: Hs.632223

SABiosciences Custom PCR Arrays for POLR3K

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLR3K Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat POLR3K
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR3K
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR3K

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for POLR3K

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR3K gene from 10/31 species (see all 31) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Polr3k^{1 , 5}	polymerase (RNA) III (DNA directed) polypeptide K^{1, 5}	89.2(n)¹ 98.15(a)¹		2 (103.82 cM)⁵ 67005¹ NM_025901.3¹ NP_080177.1¹ 181864337⁵
chicken (Gallus gallus)	Aves	POLR3K¹	polymerase (RNA) III (DNA directed) polypeptide K, more	77.16(n) 87.04(a)		768505 XM_001231485.2 XP_001231486.2
lizard (Anolis carolinensis)	Reptilia	POLR3K⁶	--	83(a)	1 ↔ 1	GL343856.1(158197-158486)
African clawed frog (Xenopus laevis)	Amphibia	MGC68582²	DNA-directed RNA polymerases III 12.5 kDa polypeptide	79.33(n)		BC061683.1
zebrafish (Danio rerio)	Actinopterygii	Dr.24992²	Transcribed sequence with strong similarity to protein more	77.25(n)		57039718
fruit fly (Drosophila melanogaster)	Insecta	CG33785⁶	--	70(a)	1 ↔ 1	2R(16529971-16531310)
worm (Caenorhabditis elegans)	Secernentea	Y77E11A.6^{1 , 3}	Protein Y77E11A.6¹	61(a)³ 62.35(n)¹ 62.04(a)¹		IV(1408712-1410042)³ 176950¹ NM_067675.2¹ NP_500076.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RPC11(YDR045C)⁴ RPC11¹	RNA polymerase III subunit C11; mediates pol III RNA more⁴ Rpc11p¹	55.77(n)¹ 55.77(a)¹		4(548310-547978)⁴ 851615^{1, 4} NP_010330.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G07950¹	DNA-directed RNA polymerase, subunit M	53.06(n) 47.96(a)		826299 NM_116865.2 NP_192535.1
rice (Oryza sativa)	Liliopsida	Os02g0672700¹	hypothetical protein	56.19(n) 43.81(a)		4330285 NM_001054243.1 NP_001047708.1

ENSEMBL Gene Tree for POLR3K (if available)
TreeFam Gene Tree for POLR3K (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for POLR3K gene

POLR3K for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for POLR3K
PGOHUM00000248413 PGOHUM00000237174 PGOHUM00000234833 PGOHUM00000236795

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs216591^1,2		--	20371(+)	`aatggC/Tgtgaa`	1	--	us2k¹		1		CSA	2
rs111702021^1,2		--	21203(+)	`ATAAAG/TAAAGC`	1	--	us2k¹		1		CSA	2
rs139339550^1,2	C,	--	21806(+)	`GCAGTC/TGNNNN`	1	--	us2k¹		0	--	--	--	--
rs28452059^1,2	C	--	22172(+)	`GCCCCA/CCCCCC`	1	--	us2k¹		1		NA	2
rs216595^1,2	C,F,	--	22324(+)	`GTGGGC/ACCGAG`	1	--	ut5¹		2		MN WA	302
rs76224996^1,2	C,F,	--	22943(+)	`CTGTAA/GTACCT`	1	--	int¹		3		WA CSA	122
rs9938569^1,2	C,A,	--	23312(+)	`atgatA/Ccgccc`	1	--	int¹		0	--	--	--	--
rs74532947^1,2	C,F,	--	23491(+)	`TGCACA/CCCTGC`	1	--	int¹		4		NA CSA	126
rs75943773^1,2	C,F,	--	23547(+)	`ATACTC/TAGCGT`	1	--	int¹		1		WA	118
rs9926790^1,2	C,F,A,H,	--	23628(+)	`GCACCT/GCTTTC`	1	--	int¹ trp³		2		NA WA	122

HapMap Linkage Disequilibrium report for POLR3K (96407 - 103632 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for POLR3K
2 CNVs: 3986 5329

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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POLR3K for disorders           About GeneDecksing

OMIM gene information: 606007    OMIM disorders: --

17 diseases for POLR3K:    About MalaCards

dna topoisomerase i systemic lupus erythematosus lupus erythematosus systemic lupus erythematosus, association with

herpes simplex sjogren's syndrome hepatitis b scleroderma

hepatocellular carcinoma microphthalmia retinoblastoma genetic disease

carcinoma hepatitis immunodeficiency malaria

neuronitis

10/18 Novoseek disease relationships for POLR3K gene (see all 18) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
renal scleroderma	68.4	1	20439528 (1)
sclerosis systemic	34.4	6	12384934 (2), 17610318 (1), 8214977 (1), 17631732 (1) (see all 5)
retinoblastoma	29.5	6	15199152 (2), 11094071 (1), 9169441 (1), 10330166 (1) (see all 5)
lupus erythematosus systemic	20.9	1	8035794 (1)
sjogrens syndrome	16	1	8035794 (1)
rheumatic diseases	11.3	2	10564276 (1), 16387655 (1)
tumors	4.67	5	15798209 (1), 16210911 (1), 11097422 (1), 15199152 (1) (see all 5)
carcinoma embryonal	3.77	1	9642284 (1)
carcinoma	3.31	2	1700854 (1), 1710020 (1)
immunodeficiency	0.524	2	9261187 (1), 8683593 (1)

Export disorders for POLR3K gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for POLR3K gene, integrated from 9 sources (see all 234):
(articles sorted by number of sources associating them with POLR3K)

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Molecular identification and characteristics of hRPC11, the smallest specific subunit of human RNA polymerase III. (PubMed id 10079944)^{1, 2, 3, 9} Spakovskii G.V. and Lebedenko E.N. (1998)
The RNA cleavage activity of RNA polymerase III is mediated by an essential TFIIS-like subunit and is important for transcription termination. (PubMed id 9869639)^{1, 2, 3} Chedin S.... Carles C. (1998)
Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PubMed id 12391170)^{1, 2, 9} Hu P....Hernandez N. (2002)
A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter. (PubMed id 16728641)^{1, 2} De Gobbi M.... Higgs D.R. (2006)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)^{1, 2} Martin J.... Pennacchio L.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)^{1, 2} Daniels R.J....Higgs D.R. (2001)
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. (PubMed id 19609254)^{2, 9} Ablasser A....Hornung V. (2009)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. (PubMed id 19631370)² Chiu Y.-H.... Chen Z.J. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51728	HGNC: 14121	AceView: POLR3K	Ensembl:ENSG00000161980	euGenes: HUgn51728
ECgene: POLR3K	Kegg: 51728	H-InvDB: POLR3K

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for POLR3K	Pharmacogenomics, SNPs, Pathways

Intellectual Property for POLR3K gene
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Patent Information for POLR3K gene:
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GeneCards and IP:
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polymerase (RNA) III (DNA directed) polypeptide K, 12.3...

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POLR3K Gene

polymerase (RNA) III (DNA directed) polypeptide K, 12.3...

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