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Aliases for POLR3K Gene

Aliases for POLR3K Gene

  • Polymerase (RNA) III (DNA Directed) Polypeptide K, 12.3 KDa 2 3
  • DNA-Directed RNA Polymerase III Subunit K 3 4
  • RNA Polymerase III 12.5 KDa Subunit 3 4
  • RNA Polymerase III Subunit C10 3 4
  • RNA Polymerase III Subunit C11 3 4
  • RPC12.5 3 4
  • RPC11 3 4
  • Polymerase (RNA) III (DNA Directed) Polypeptide K (12.3 KDa) 2
  • DNA-Directed RNA Polymerases III 12.5 KDa Polypeptide 3
  • DNA-Directed RNA Polymerase III Subunit RPC10 3
  • RNA Polymerase III Subunit CII 3
  • C11-RNP3 3
  • HsC11p 4
  • HRPC11 4
  • My010 3
  • RPC10 3
  • C11 3

External Ids for POLR3K Gene

Summaries for POLR3K Gene

Entrez Gene Summary for POLR3K Gene

  • This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17.[provided by RefSeq, Jul 2010]

GeneCards Summary for POLR3K Gene

POLR3K (Polymerase (RNA) III (DNA Directed) Polypeptide K, 12.3 KDa) is a Protein Coding gene. Diseases associated with POLR3K include rheumatic disease and herpes simplex. Among its related pathways are Epstein-Barr virus infection and Metabolism. GO annotations related to this gene include DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot for POLR3K Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Gene Wiki entry for POLR3K Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR3K Gene

Genomics for POLR3K Gene

Genomic Location for POLR3K Gene

Start:
46,407 bp from pter
End:
53,632 bp from pter
Size:
7,226 bases
Orientation:
Minus strand

Genomic View for POLR3K Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POLR3K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR3K Gene

Regulatory Elements for POLR3K Gene

Proteins for POLR3K Gene

  • Protein details for POLR3K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Y1-RPC10_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC10
    Protein Accession:
    Q9Y2Y1
    Secondary Accessions:
    • Q1W6H4
    • Q96S35

    Protein attributes for POLR3K Gene

    Size:
    108 amino acids
    Molecular mass:
    12336 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.

neXtProt entry for POLR3K Gene

Proteomics data for POLR3K Gene at MOPED

Post-translational modifications for POLR3K Gene

No Post-translational modifications

Other Protein References for POLR3K Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for POLR3K Gene

Domains for POLR3K Gene

Gene Families for POLR3K Gene

HGNC:
  • POLR :RNA polymerase subunits

UniProtKB/Swiss-Prot:

RPC10_HUMAN
Family:
  • Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.:
    • Q9Y2Y1
Similarity:
  • Contains 1 TFIIS-type zinc finger.:
    • Q9Y2Y1
genes like me logo Genes that share domains with POLR3K: view

Function for POLR3K Gene

Molecular function for POLR3K Gene

UniProtKB/Swiss-Prot Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Gene Ontology (GO) - Molecular Function for POLR3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001056 contributes_to RNA polymerase III activity IBA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed RNA polymerase activity TAS 9869639
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with POLR3K: view

Phenotypes for POLR3K Gene

GenomeRNAi human phenotypes for POLR3K:
genes like me logo Genes that share phenotypes with POLR3K: view

miRNA for POLR3K Gene

miRTarBase miRNAs that target POLR3K

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for POLR3K Gene

Localization for POLR3K Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR3K Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR3K Gene COMPARTMENTS Subcellular localization image for POLR3K gene
Compartment Confidence
nucleus 4
extracellular 3
cytosol 1

Gene Ontology (GO) - Cellular Components for POLR3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005666 DNA-directed RNA polymerase III complex IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR3K: view

Pathways for POLR3K Gene

genes like me logo Genes that share pathways with POLR3K: view

Gene Ontology (GO) - Biological Process for POLR3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006383 transcription from RNA polymerase III promoter TAS --
GO:0006385 transcription elongation from RNA polymerase III promoter TAS --
GO:0006386 termination of RNA polymerase III transcription TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with POLR3K: view

Compounds for POLR3K Gene

(6) HMDB Compounds for POLR3K Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Cytidine triphosphate
  • cytidine 5'-(tetrahydrogen triphosphate)
65-47-4
Guanosine triphosphate
  • 5'-GTP
86-01-1
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(19) Novoseek inferred chemical compound relationships for POLR3K Gene

Compound -log(P) Hits PubMed IDs
s-napc 79.9 4
alpha-amanitin 76.7 8
phosphocellulose 66.1 2
tagetitoxin 64.8 2
trna 62.2 5
genes like me logo Genes that share compounds with POLR3K: view

Transcripts for POLR3K Gene

mRNA/cDNA for POLR3K Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(107) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POLR3K Gene

Polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLR3K Gene

No ASD Table

Relevant External Links for POLR3K Gene

GeneLoc Exon Structure for
POLR3K
ECgene alternative splicing isoforms for
POLR3K

Expression for POLR3K Gene

mRNA expression in normal human tissues for POLR3K Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLR3K Gene

SOURCE GeneReport for Unigene cluster for POLR3K Gene Hs.632223

genes like me logo Genes that share expressions with POLR3K: view

Orthologs for POLR3K Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POLR3K Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR3K 36
  • 99.07 (n)
  • 98.15 (a)
POLR3K 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POLR3K 36
  • 91.67 (n)
  • 95.37 (a)
POLR3K 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR3K 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr3k 36
  • 89.2 (n)
  • 98.15 (a)
Polr3k 16
Polr3k 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLR3K 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polr3k 36
  • 91.05 (n)
  • 98.15 (a)
chicken
(Gallus gallus)
Aves POLR3K 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLR3K 37
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68582 36
tropical clawed frog
(Silurana tropicalis)
Amphibia polr3k 36
  • 76.23 (n)
  • 88.89 (a)
Str.787 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9441 36
zebrafish
(Danio rerio)
Actinopterygii Dr.24992 36
polr3k 36
  • 76.23 (n)
  • 91.67 (a)
polr3k 37
  • 92 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG33785 36
  • 66.05 (n)
  • 70.37 (a)
CG33785 37
  • 70 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpc-11 37
  • 62 (a)
OneToOne
Y77E11A.6 36
  • 62.35 (n)
  • 62.04 (a)
Y77E11A.6 38
  • 61 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR029W 36
  • 61.95 (n)
  • 56.6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPC11 36
  • 55.77 (n)
  • 55.77 (a)
RPC11 37
  • 53 (a)
OneToOne
RPC11 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F18568g 36
  • 59.12 (n)
  • 58.49 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00570 36
  • 52.98 (n)
  • 46.32 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpc11 36
  • 53.72 (n)
  • 54.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 79 (a)
OneToOne
Species with no ortholog for POLR3K:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR3K Gene

ENSEMBL:
Gene Tree for POLR3K (if available)
TreeFam:
Gene Tree for POLR3K (if available)

Paralogs for POLR3K Gene

Pseudogenes.org Pseudogenes for POLR3K Gene

genes like me logo Genes that share paralogs with POLR3K: view

No data available for Paralogs for POLR3K Gene

Variants for POLR3K Gene

Sequence variations from dbSNP and Humsavar for POLR3K Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs8466 -- 47,354(-) TGAGT(C/T)GTGTG utr-variant-3-prime
rs216587 -- 50,147(+) agaaa(C/T)ggggt intron-variant
rs216588 -- 50,244(+) gtgag(C/T)cacca intron-variant
rs216589 -- 50,654(+) agcag(C/T)tgggt intron-variant
rs216590 -- 51,263(+) CTCGC(A/G)GTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR3K Gene

Variant ID Type Subtype PubMed ID
nsv904623 CNV Gain+Loss 21882294
dgv2455n71 CNV Loss 21882294
esv2422427 CNV Duplication 17116639
dgv789e1 CNV Complex 17122850
nsv522688 CNV Loss 19592680
nsv518291 CNV Loss 19592680
dgv2456n71 CNV Loss 21882294

Relevant External Links for POLR3K Gene

HapMap Linkage Disequilibrium report
POLR3K

Disorders for POLR3K Gene

(18) Novoseek inferred disease relationships for POLR3K Gene

Disease -log(P) Hits PubMed IDs
renal scleroderma 68.4 1
sclerosis systemic 34.4 6
retinoblastoma 29.5 6
lupus erythematosus systemic 20.9 1
sjogrens syndrome 16 1
genes like me logo Genes that share disorders with POLR3K: view

No data available for UniProtKB/Swiss-Prot for POLR3K Gene

Publications for POLR3K Gene

  1. Molecular identification and characteristics of hRPC11, the smallest specific subunit of human RNA polymerase III. (PMID: 10079944) Spakovskii G.V. … Lebedenko E.N. (Bioorg. Khim. 1998) 2 3 4 23
  2. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PMID: 12391170) Hu P. … Hernandez N. (Mol. Cell. Biol. 2002) 3 4 23
  3. The RNA cleavage activity of RNA polymerase III is mediated by an essential TFIIS-like subunit and is important for transcription termination. (PMID: 9869639) Chedin S. … Carles C. (Genes Dev. 1998) 2 3 4
  4. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4
  5. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. (PMID: 19609254) Ablasser A. … Hornung V. (Nat. Immunol. 2009) 4 23

Products for POLR3K Gene

Sources for POLR3K Gene

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