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Aliases for POLR3K Gene

Aliases for POLR3K Gene

  • RNA Polymerase III Subunit K 2 3 5
  • Polymerase (RNA) III (DNA Directed) Polypeptide K, 12.3 KDa 2 3
  • DNA-Directed RNA Polymerase III Subunit K 3 4
  • RNA Polymerase III 12.5 KDa Subunit 3 4
  • RNA Polymerase III Subunit C10 3 4
  • RNA Polymerase III Subunit C11 3 4
  • RPC12.5 3 4
  • RPC11 3 4
  • DNA-Directed RNA Polymerases III 12.5 KDa Polypeptide 3
  • DNA-Directed RNA Polymerase III Subunit RPC10 3
  • RNA Polymerase III Subunit CII 3
  • Polymerase (RNA) III Subunit K 3
  • C11-RNP3 3
  • HsC11p 4
  • HRPC11 4
  • My010 3
  • RPC10 3
  • C11 3

External Ids for POLR3K Gene

Previous GeneCards Identifiers for POLR3K Gene

  • GC16M000115
  • GC16M000036
  • GC16M000015
  • GC16M000096

Summaries for POLR3K Gene

Entrez Gene Summary for POLR3K Gene

  • This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17.[provided by RefSeq, Jul 2010]

GeneCards Summary for POLR3K Gene

POLR3K (RNA Polymerase III Subunit K) is a Protein Coding gene. Diseases associated with POLR3K include Spherocytosis, Hereditary, Type 5. Among its related pathways are Innate Immune System and RNA Polymerase III Transcription Initiation. GO annotations related to this gene include nucleic acid binding and RNA polymerase III activity.

UniProtKB/Swiss-Prot for POLR3K Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Gene Wiki entry for POLR3K Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR3K Gene

Genomics for POLR3K Gene

Regulatory Elements for POLR3K Gene

Enhancers for POLR3K Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G000052 1.1 ENCODE 10 -0.1 -70 2.0 HDGF PKNOX1 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SNRNP25 ENSG00000268836 POLR3K GC16P000130
GH16G000122 1.2 ENCODE dbSUPER 5 -70.6 -70559 3.7 HDGF HDAC1 PKNOX1 NFIB KLF17 SIN3A NFXL1 ZNF335 GLIS2 EGR2 NPRL3 SNRNP25 POLR3K ENSG00000228779 GC16P000124
GH16G000065 1.5 Ensembl ENCODE dbSUPER 0.4 -12.3 -12311 0.5 HDGF ATF1 ARID4B SIN3A ZNF2 ZNF48 SLC30A9 ZNF143 ZNF207 DEK NPRL3 ENSG00000228779 GC16P000130 POLR3K
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLR3K on UCSC Golden Path with GeneCards custom track

Promoters for POLR3K Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082115 132 1801 HDGF PKNOX1 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for POLR3K Gene

Chromosome:
16
Start:
46,407 bp from pter
End:
53,632 bp from pter
Size:
7,226 bases
Orientation:
Minus strand

Genomic View for POLR3K Gene

Genes around POLR3K on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR3K Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR3K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR3K Gene

Proteins for POLR3K Gene

  • Protein details for POLR3K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Y1-RPC10_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC10
    Protein Accession:
    Q9Y2Y1
    Secondary Accessions:
    • Q1W6H4
    • Q96S35

    Protein attributes for POLR3K Gene

    Size:
    108 amino acids
    Molecular mass:
    12336 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.

neXtProt entry for POLR3K Gene

Post-translational modifications for POLR3K Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POLR3K Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POLR3K Gene

Domains & Families for POLR3K Gene

Gene Families for POLR3K Gene

Suggested Antigen Peptide Sequences for POLR3K Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2Y1

UniProtKB/Swiss-Prot:

RPC10_HUMAN :
  • Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
Family:
  • Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
genes like me logo Genes that share domains with POLR3K: view

Function for POLR3K Gene

Molecular function for POLR3K Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Gene Ontology (GO) - Molecular Function for POLR3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003899 DNA-directed 5-3 RNA polymerase activity IEA,TAS --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with POLR3K: view
genes like me logo Genes that share phenotypes with POLR3K: view

Animal Model Products

  • Taconic Biosciences Mouse Models for POLR3K

CRISPR Products

miRNA for POLR3K Gene

miRTarBase miRNAs that target POLR3K

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR3K Gene

Localization for POLR3K Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR3K Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR3K gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 3

Gene Ontology (GO) - Cellular Components for POLR3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005666 DNA-directed RNA polymerase III complex TAS 9869639
GO:0005730 nucleolus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR3K: view

Pathways & Interactions for POLR3K Gene

genes like me logo Genes that share pathways with POLR3K: view

Gene Ontology (GO) - Biological Process for POLR3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006379 mRNA cleavage IEA --
GO:0006383 transcription from RNA polymerase III promoter TAS 9869639
GO:0032481 positive regulation of type I interferon production TAS --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with POLR3K: view

No data available for SIGNOR curated interactions for POLR3K Gene

Drugs & Compounds for POLR3K Gene

(13) Drugs for POLR3K Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0

(12) Additional Compounds for POLR3K Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with POLR3K: view

Transcripts for POLR3K Gene

mRNA/cDNA for POLR3K Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(107) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POLR3K Gene

Polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR3K Gene

No ASD Table

Relevant External Links for POLR3K Gene

GeneLoc Exon Structure for
POLR3K
ECgene alternative splicing isoforms for
POLR3K

Expression for POLR3K Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR3K Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR3K Gene

This gene is overexpressed in Pancreas (34.7), Retina (21.3), and Fetal ovary (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POLR3K Gene



Protein tissue co-expression partners for POLR3K Gene

NURSA nuclear receptor signaling pathways regulating expression of POLR3K Gene:

POLR3K

SOURCE GeneReport for Unigene cluster for POLR3K Gene:

Hs.632223

Evidence on tissue expression from TISSUES for POLR3K Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with POLR3K: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR3K Gene

Orthologs for POLR3K Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POLR3K Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR3K 34 35
  • 99.07 (n)
dog
(Canis familiaris)
Mammalia POLR3K 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POLR3K 34 35
  • 91.67 (n)
rat
(Rattus norvegicus)
Mammalia Polr3k 34
  • 91.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia POLR3K 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr3k 34 16 35
  • 89.2 (n)
chicken
(Gallus gallus)
Aves POLR3K 35
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLR3K 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr3k 34
  • 76.23 (n)
Str.787 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68582 34
zebrafish
(Danio rerio)
Actinopterygii polr3k 34 35
  • 76.23 (n)
Dr.24992 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9441 34
fruit fly
(Drosophila melanogaster)
Insecta CG33785 34 35
  • 66.05 (n)
worm
(Caenorhabditis elegans)
Secernentea Y77E11A.6 36 34
  • 62.35 (n)
rpc-11 35
  • 62 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR029W 34
  • 61.95 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F18568g 34
  • 59.12 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPC11 34 35 37
  • 55.77 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 79 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpc11 34
  • 53.72 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00570 34
  • 52.98 (n)
Species where no ortholog for POLR3K was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR3K Gene

ENSEMBL:
Gene Tree for POLR3K (if available)
TreeFam:
Gene Tree for POLR3K (if available)

Paralogs for POLR3K Gene

Pseudogenes.org Pseudogenes for POLR3K Gene

genes like me logo Genes that share paralogs with POLR3K: view

No data available for Paralogs for POLR3K Gene

Variants for POLR3K Gene

Sequence variations from dbSNP and Humsavar for POLR3K Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000268642 -- 54,809(+) CCTCC(C/T)GGGTT intron-variant, upstream-variant-2KB
rs1000789770 -- 49,781(+) ATTAC(A/C)GGCAG intron-variant
rs1001032004 -- 54,278(+) AAATG(A/G)CATTT intron-variant, upstream-variant-2KB
rs1001400177 -- 55,006(+) TGCTC(A/C)TCATG intron-variant, upstream-variant-2KB
rs1001463169 -- 54,071(+) CGGGC(G/T)GGGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for POLR3K Gene

Variant ID Type Subtype PubMed ID
dgv2688n100 CNV gain 25217958
dgv2689n100 CNV gain 25217958
dgv2690n100 CNV gain 25217958
esv2422427 CNV duplication 17116639
esv2760065 CNV gain 17122850
esv3637535 CNV loss 21293372
nsv1037456 CNV gain+loss 25217958
nsv1044142 CNV gain 25217958
nsv1044732 CNV loss 25217958
nsv1045829 CNV gain 25217958
nsv518291 CNV loss 19592680
nsv522688 CNV loss 19592680

Variation tolerance for POLR3K Gene

Residual Variation Intolerance Score: 48.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR3K Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR3K

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR3K Gene

Disorders for POLR3K Gene

MalaCards: The human disease database

(1) MalaCards diseases for POLR3K Gene - From: DISEASES

Disorder Aliases PubMed IDs
spherocytosis, hereditary, type 5
  • hereditary spherocytosis type 5
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POLR3K

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR3K
genes like me logo Genes that share disorders with POLR3K: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR3K Gene

Publications for POLR3K Gene

  1. Molecular identification and characteristics of hRPC11, the smallest specific subunit of human RNA polymerase III. (PMID: 10079944) Spakovskii G.V. … Lebedenko E.N. (Bioorg. Khim. 1998) 2 3 4 22 64
  2. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PMID: 12391170) Hu P. … Hernandez N. (Mol. Cell. Biol. 2002) 3 4 22 64
  3. The RNA cleavage activity of RNA polymerase III is mediated by an essential TFIIS-like subunit and is important for transcription termination. (PMID: 9869639) Chedin S. … Carles C. (Genes Dev. 1998) 2 3 4 64
  4. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. (PMID: 19609254) Ablasser A. … Hornung V. (Nat. Immunol. 2009) 4 22 64
  5. A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter. (PMID: 16728641) De Gobbi M. … Higgs D.R. (Science 2006) 3 4 64

Products for POLR3K Gene

Sources for POLR3K Gene

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