Aliases for POLR3K Gene
- Polymerase (RNA) III (DNA Directed) Polypeptide K, 12.3 KDa 2 3
- DNA-Directed RNA Polymerase III Subunit K 3 4
- RNA Polymerase III 12.5 KDa Subunit 3 4
- RNA Polymerase III Subunit C10 3 4
- RNA Polymerase III Subunit C11 3 4
- RPC12.5 3 4
- RPC11 3 4
- Polymerase (RNA) III (DNA Directed) Polypeptide K (12.3 KDa) 2
- DNA-Directed RNA Polymerases III 12.5 KDa Polypeptide 3
External Ids for POLR3K Gene
This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17.[provided by RefSeq, Jul 2010]
GeneCards Summary for POLR3K Gene
POLR3K (Polymerase (RNA) III (DNA Directed) Polypeptide K, 12.3 KDa) is a Protein Coding gene. Diseases associated with POLR3K include rheumatic disease and herpes simplex. Among its related pathways are Epstein-Barr virus infection and Metabolism. GO annotations related to this gene include DNA-directed RNA polymerase activity.
UniProtKB/Swiss-Prot for POLR3K Gene
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).