Free for academic non-profit institutions. Other users need a Commercial license

Aliases for POLR3K Gene

Aliases for POLR3K Gene

  • Polymerase (RNA) III Subunit K 2 3
  • Polymerase (RNA) III (DNA Directed) Polypeptide K, 12.3 KDa 2 3 5
  • DNA-Directed RNA Polymerase III Subunit K 3 4
  • RNA Polymerase III 12.5 KDa Subunit 3 4
  • RNA Polymerase III Subunit C10 3 4
  • RNA Polymerase III Subunit C11 3 4
  • RPC12.5 3 4
  • RPC11 3 4
  • DNA-Directed RNA Polymerases III 12.5 KDa Polypeptide 3
  • RNA Polymerase III Subunit CII 3
  • C11-RNP3 3
  • HsC11p 4
  • HRPC11 4
  • My010 3
  • RPC10 3
  • C11 3

External Ids for POLR3K Gene

Previous GeneCards Identifiers for POLR3K Gene

  • GC16M000115
  • GC16M000036
  • GC16M000015
  • GC16M000096

Summaries for POLR3K Gene

Entrez Gene Summary for POLR3K Gene

  • This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17.[provided by RefSeq, Jul 2010]

GeneCards Summary for POLR3K Gene

POLR3K (Polymerase (RNA) III Subunit K) is a Protein Coding gene. Diseases associated with POLR3K include Rheumatic Disease. Among its related pathways are RNA Polymerase III Transcription Initiation and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA polymerase III activity.

UniProtKB/Swiss-Prot for POLR3K Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Gene Wiki entry for POLR3K Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR3K Gene

Genomics for POLR3K Gene

Regulatory Elements for POLR3K Gene

Enhancers for POLR3K Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POLR3K on UCSC Golden Path with GeneCards custom track

Promoters for POLR3K Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POLR3K on UCSC Golden Path with GeneCards custom track

Genomic Location for POLR3K Gene

Chromosome:
16
Start:
46,407 bp from pter
End:
53,632 bp from pter
Size:
7,226 bases
Orientation:
Minus strand

Genomic View for POLR3K Gene

Genes around POLR3K on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR3K Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR3K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR3K Gene

Proteins for POLR3K Gene

  • Protein details for POLR3K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Y1-RPC10_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC10
    Protein Accession:
    Q9Y2Y1
    Secondary Accessions:
    • Q1W6H4
    • Q96S35

    Protein attributes for POLR3K Gene

    Size:
    108 amino acids
    Molecular mass:
    12336 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.

neXtProt entry for POLR3K Gene

Proteomics data for POLR3K Gene at MOPED

Post-translational modifications for POLR3K Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POLR3K Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POLR3K Gene

Domains & Families for POLR3K Gene

Gene Families for POLR3K Gene

Suggested Antigen Peptide Sequences for POLR3K Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2Y1

UniProtKB/Swiss-Prot:

RPC10_HUMAN :
  • Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
  • Contains 1 TFIIS-type zinc finger.
Family:
  • Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
Similarity:
  • Contains 1 TFIIS-type zinc finger.
genes like me logo Genes that share domains with POLR3K: view

Function for POLR3K Gene

Molecular function for POLR3K Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Gene Ontology (GO) - Molecular Function for POLR3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003899 DNA-directed RNA polymerase activity IEA,TAS 9869639
genes like me logo Genes that share ontologies with POLR3K: view
genes like me logo Genes that share phenotypes with POLR3K: view

Animal Model Products

  • Taconic Biosciences Mouse Models for POLR3K

miRNA for POLR3K Gene

miRTarBase miRNAs that target POLR3K

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR3K Gene

Localization for POLR3K Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR3K Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR3K Gene COMPARTMENTS Subcellular localization image for POLR3K gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 3

Gene Ontology (GO) - Cellular Components for POLR3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR3K: view

Pathways & Interactions for POLR3K Gene

genes like me logo Genes that share pathways with POLR3K: view

Gene Ontology (GO) - Biological Process for POLR3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006383 transcription from RNA polymerase III promoter TAS 9869639
GO:0032481 positive regulation of type I interferon production TAS --
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with POLR3K: view

No data available for SIGNOR curated interactions for POLR3K Gene

Drugs & Compounds for POLR3K Gene

(12) Drugs for POLR3K Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0

(13) Additional Compounds for POLR3K Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with POLR3K: view

Transcripts for POLR3K Gene

mRNA/cDNA for POLR3K Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(107) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POLR3K Gene

Polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLR3K Gene

No ASD Table

Relevant External Links for POLR3K Gene

GeneLoc Exon Structure for
POLR3K
ECgene alternative splicing isoforms for
POLR3K

Expression for POLR3K Gene

mRNA expression in normal human tissues for POLR3K Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR3K Gene

This gene is overexpressed in Pancreas (34.7), Retina (21.3), and Fetal ovary (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLR3K Gene



SOURCE GeneReport for Unigene cluster for POLR3K Gene Hs.632223

genes like me logo Genes that share expression patterns with POLR3K: view

Protein tissue co-expression partners for POLR3K Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLR3K Gene

Orthologs for POLR3K Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POLR3K Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POLR3K 35
  • 91.67 (n)
  • 95.37 (a)
POLR3K 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr3k 35
  • 89.2 (n)
  • 98.15 (a)
Polr3k 16
Polr3k 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLR3K 35
  • 99.07 (n)
  • 98.15 (a)
POLR3K 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polr3k 35
  • 91.05 (n)
  • 98.15 (a)
dog
(Canis familiaris)
Mammalia POLR3K 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLR3K 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves POLR3K 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLR3K 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr3k 35
  • 76.23 (n)
  • 88.89 (a)
Str.787 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68582 35
zebrafish
(Danio rerio)
Actinopterygii Dr.24992 35
polr3k 35
  • 76.23 (n)
  • 91.67 (a)
polr3k 36
  • 92 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9441 35
fruit fly
(Drosophila melanogaster)
Insecta CG33785 35
  • 66.05 (n)
  • 70.37 (a)
CG33785 36
  • 70 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y77E11A.6 37
  • 61 (a)
Y77E11A.6 35
  • 62.35 (n)
  • 62.04 (a)
rpc-11 36
  • 62 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR029W 35
  • 61.95 (n)
  • 56.6 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F18568g 35
  • 59.12 (n)
  • 58.49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPC11 35
  • 55.77 (n)
  • 55.77 (a)
RPC11 36
  • 53 (a)
OneToOne
RPC11 38
bread mold
(Neurospora crassa)
Ascomycetes NCU00570 35
  • 52.98 (n)
  • 46.32 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpc11 35
  • 53.72 (n)
  • 54.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 79 (a)
OneToOne
Species with no ortholog for POLR3K:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR3K Gene

ENSEMBL:
Gene Tree for POLR3K (if available)
TreeFam:
Gene Tree for POLR3K (if available)

Paralogs for POLR3K Gene

Pseudogenes.org Pseudogenes for POLR3K Gene

genes like me logo Genes that share paralogs with POLR3K: view

No data available for Paralogs for POLR3K Gene

Variants for POLR3K Gene

Sequence variations from dbSNP and Humsavar for POLR3K Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_027918 -
rs8466 -- 47,354(-) TGAGT(C/T)GTGTG utr-variant-3-prime
rs216587 -- 50,147(+) agaaa(C/T)ggggt intron-variant
rs216588 -- 50,244(+) gtgag(C/T)cacca intron-variant
rs216589 -- 50,654(+) agcag(C/T)tgggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR3K Gene

Variant ID Type Subtype PubMed ID
nsv904623 CNV Gain+Loss 21882294
dgv2455n71 CNV Loss 21882294
esv2422427 CNV Duplication 17116639
dgv789e1 CNV Complex 17122850
nsv522688 CNV Loss 19592680
nsv518291 CNV Loss 19592680
dgv2456n71 CNV Loss 21882294

Variation tolerance for POLR3K Gene

Residual Variation Intolerance Score: 48.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.33% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for POLR3K Gene

Disorders for POLR3K Gene

MalaCards: The human disease database

(1) MalaCards diseases for POLR3K Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
rheumatic disease
  • rheumatic diseases
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POLR3K

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR3K
genes like me logo Genes that share disorders with POLR3K: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR3K Gene

Publications for POLR3K Gene

  1. Molecular identification and characteristics of hRPC11, the smallest specific subunit of human RNA polymerase III. (PMID: 10079944) Spakovskii G.V. … Lebedenko E.N. (Bioorg. Khim. 1998) 2 3 4 23 67
  2. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PMID: 12391170) Hu P. … Hernandez N. (Mol. Cell. Biol. 2002) 3 23
  3. The RNA cleavage activity of RNA polymerase III is mediated by an essential TFIIS-like subunit and is important for transcription termination. (PMID: 9869639) Chedin S. … Carles C. (Genes Dev. 1998) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for POLR3K Gene

Sources for POLR3K Gene

Content