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Aliases for POLR3H Gene

Aliases for POLR3H Gene

  • Polymerase (RNA) III (DNA Directed) Polypeptide H (22.9kD) 2 3
  • DNA-Directed RNA Polymerase III Subunit H 3 4
  • RNA Polymerase III Subunit C8 3 4
  • RPC22.9 3 4
  • RPC8 3 4
  • DNA-Directed RNA Polymerase III Subunit 22.9 KDa Polypeptide 3
  • DNA-Directed RNA Polymerase III Subunit RPC8 3
  • RNA Polymerase III Subunit 22.9 KDa Subunit 4
  • RNA Nucleotidyltransferase (DNA-Directed) 3
  • KIAA1665 4

External Ids for POLR3H Gene

Previous GeneCards Identifiers for POLR3H Gene

  • GC22M040166
  • GC22M040246
  • GC22M041921
  • GC22M024887

Summaries for POLR3H Gene

GeneCards Summary for POLR3H Gene

POLR3H (Polymerase (RNA) III (DNA Directed) Polypeptide H (22.9kD)) is a Protein Coding gene. Among its related pathways are Epstein-Barr virus infection and Metabolism. GO annotations related to this gene include DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot for POLR3H Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR3H Gene

Genomics for POLR3H Gene

Regulatory Elements for POLR3H Gene

Genomic Location for POLR3H Gene

Start:
41,525,799 bp from pter
End:
41,544,606 bp from pter
Size:
18,808 bases
Orientation:
Minus strand

Genomic View for POLR3H Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POLR3H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR3H Gene

Proteins for POLR3H Gene

  • Protein details for POLR3H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y535-RPC8_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC8
    Protein Accession:
    Q9Y535
    Secondary Accessions:
    • B0QYH9
    • Q5M7Y8
    • Q96AE3
    • Q9BY95

    Protein attributes for POLR3H Gene

    Size:
    204 amino acids
    Molecular mass:
    22918 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). Interacts with CRCP/RPC9. POLR3H/RPC8 and CRCP/RPC9 probably form a Pol III subcomplex.
    SequenceCaution:
    • Sequence=BAB33335.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for POLR3H Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLR3H Gene

Proteomics data for POLR3H Gene at MOPED

Post-translational modifications for POLR3H Gene

No Post-translational modifications

No data available for DME Specific Peptides for POLR3H Gene

Domains for POLR3H Gene

Gene Families for POLR3H Gene

HGNC:
  • POLR :RNA polymerase subunits

Protein Domains for POLR3H Gene

Suggested Antigen Peptide Sequences for POLR3H Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y535

UniProtKB/Swiss-Prot:

RPC8_HUMAN :
  • Q9Y535
Family:
  • Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR3H: view

Function for POLR3H Gene

Molecular function for POLR3H Gene

UniProtKB/Swiss-Prot Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Gene Ontology (GO) - Molecular Function for POLR3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001056 contributes_to RNA polymerase III activity IBA --
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed RNA polymerase activity IDA 12391170
genes like me logo Genes that share ontologies with POLR3H: view

Phenotypes for POLR3H Gene

GenomeRNAi human phenotypes for POLR3H:
genes like me logo Genes that share phenotypes with POLR3H: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for POLR3H Gene

Localization for POLR3H Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR3H Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR3H Gene COMPARTMENTS Subcellular localization image for POLR3H gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for POLR3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005666 DNA-directed RNA polymerase III complex IDA 12391170
GO:0005813 centrosome IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR3H: view

Pathways for POLR3H Gene

genes like me logo Genes that share pathways with POLR3H: view

Gene Ontology (GO) - Biological Process for POLR3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process IDA 12391170
GO:0006351 transcription, DNA-templated --
GO:0006383 transcription from RNA polymerase III promoter TAS --
GO:0006384 transcription initiation from RNA polymerase III promoter IBA --
GO:0006385 transcription elongation from RNA polymerase III promoter TAS --
genes like me logo Genes that share ontologies with POLR3H: view

Compounds for POLR3H Gene

(6) HMDB Compounds for POLR3H Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Cytidine triphosphate
  • cytidine 5'-(tetrahydrogen triphosphate)
65-47-4
Guanosine triphosphate
  • 5'-GTP
86-01-1
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with POLR3H: view

Transcripts for POLR3H Gene

Unigene Clusters for POLR3H Gene

Polymerase (RNA) III (DNA directed) polypeptide H (22.9kD):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLR3H Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - -
SP6: - - - -
SP7: - - - -
SP8: - - - -

Relevant External Links for POLR3H Gene

GeneLoc Exon Structure for
POLR3H
ECgene alternative splicing isoforms for
POLR3H

Expression for POLR3H Gene

mRNA expression in normal human tissues for POLR3H Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLR3H Gene

SOURCE GeneReport for Unigene cluster for POLR3H Gene Hs.712617

genes like me logo Genes that share expressions with POLR3H: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLR3H Gene

Orthologs for POLR3H Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR3H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR3H 35
  • 99.51 (n)
  • 100 (a)
POLR3H 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POLR3H 35
  • 88.56 (n)
  • 95.1 (a)
POLR3H 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR3H 35
  • 92.16 (n)
  • 96.57 (a)
POLR3H 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr3h 35
  • 89.54 (n)
  • 98.04 (a)
Polr3h 16
Polr3h 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLR3H 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Polr3h 35
  • 89.71 (n)
  • 98.04 (a)
chicken
(Gallus gallus)
Aves POLR3H 35
  • 81.37 (n)
  • 89.22 (a)
POLR3H 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLR3H 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr3h 35
  • 77.29 (n)
  • 88.73 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5767 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13091 35
polr3h 35
  • 75.7 (n)
  • 83.25 (a)
polr3h 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012122 35
  • 62.58 (n)
  • 58.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7339 35
  • 62.96 (n)
  • 60.61 (a)
CG7339 36
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpc-25 36
  • 33 (a)
OneToOne
ZK856.10 35
  • 47.86 (n)
  • 41.03 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR049W 35
  • 52.19 (n)
  • 44.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPC25 35
  • 49.16 (n)
  • 46.46 (a)
RPC25 36
  • 43 (a)
OneToOne
RPC25 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E13751g 35
  • 50.34 (n)
  • 43.43 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06790 35
  • 49.21 (n)
  • 38.74 (a)
rice
(Oryza sativa)
Liliopsida Os07g0477000 35
  • 51.68 (n)
  • 42.33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpc25 35
  • 53 (n)
  • 45 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2134 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToOne
Species with no ortholog for POLR3H:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR3H Gene

ENSEMBL:
Gene Tree for POLR3H (if available)
TreeFam:
Gene Tree for POLR3H (if available)

Paralogs for POLR3H Gene

No data available for Paralogs for POLR3H Gene

Variants for POLR3H Gene

Sequence variations from dbSNP and Humsavar for POLR3H Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs169407 -- 41,539,059(+) cgttc(A/G)agacc intron-variant
rs172150 -- 41,536,121(+) ggcgc(A/G)gtggc intron-variant
rs175919 -- 41,536,145(+) cccag(A/C/T)acttt intron-variant
rs203313 -- 41,531,801(-) TTCCG(A/G)TTCAC intron-variant
rs203314 -- 41,529,971(-) gagac(C/T)atcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR3H Gene

Variant ID Type Subtype PubMed ID
nsv524585 CNV Loss 19592680
nsv516925 CNV Loss 19592680
nsv834208 CNV Loss 17160897

Relevant External Links for POLR3H Gene

HapMap Linkage Disequilibrium report
POLR3H

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR3H Gene

Disorders for POLR3H Gene

No disorders were found for POLR3H Gene.

No data available for UniProtKB/Swiss-Prot for POLR3H Gene

Publications for POLR3H Gene

  1. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PMID: 11258795) Hirosawa M. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PMID: 12391170) Hu P. … Hernandez N. (Mol. Cell. Biol. 2002) 2 3 4
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for POLR3H Gene

Sources for POLR3H Gene

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