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Aliases for POLR3H Gene

Aliases for POLR3H Gene

  • Polymerase (RNA) III Subunit H 2 3
  • Polymerase (RNA) III (DNA Directed) Polypeptide H (22.9kD) 2 3 5
  • DNA-Directed RNA Polymerase III Subunit H 3 4
  • RNA Polymerase III Subunit C8 3 4
  • RPC22.9 3 4
  • RPC8 3 4
  • DNA-Directed RNA Polymerase III Subunit 22.9 KDa Polypeptide 3
  • RNA Polymerase III Subunit 22.9 KDa Subunit 4
  • RNA Nucleotidyltransferase (DNA-Directed) 3
  • KIAA1665 4

External Ids for POLR3H Gene

Previous GeneCards Identifiers for POLR3H Gene

  • GC22M040166
  • GC22M040246
  • GC22M041921
  • GC22M024887

Summaries for POLR3H Gene

GeneCards Summary for POLR3H Gene

POLR3H (Polymerase (RNA) III Subunit H) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include DNA-directed RNA polymerase activity and RNA polymerase III activity.

UniProtKB/Swiss-Prot for POLR3H Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR3H Gene

Genomics for POLR3H Gene

Regulatory Elements for POLR3H Gene

Promoters for POLR3H Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POLR3H on UCSC Golden Path with GeneCards custom track

Genomic Location for POLR3H Gene

Chromosome:
22
Start:
41,525,799 bp from pter
End:
41,544,606 bp from pter
Size:
18,808 bases
Orientation:
Minus strand

Genomic View for POLR3H Gene

Genes around POLR3H on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR3H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR3H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR3H Gene

Proteins for POLR3H Gene

  • Protein details for POLR3H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y535-RPC8_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC8
    Protein Accession:
    Q9Y535
    Secondary Accessions:
    • B0QYH9
    • Q5M7Y8
    • Q96AE3
    • Q9BY95

    Protein attributes for POLR3H Gene

    Size:
    204 amino acids
    Molecular mass:
    22918 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). Interacts with CRCP/RPC9. POLR3H/RPC8 and CRCP/RPC9 probably form a Pol III subcomplex.
    SequenceCaution:
    • Sequence=BAB33335.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for POLR3H Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLR3H Gene

Proteomics data for POLR3H Gene at MOPED

Post-translational modifications for POLR3H Gene

No Post-translational modifications

Antibody Products

No data available for DME Specific Peptides for POLR3H Gene

Domains & Families for POLR3H Gene

Gene Families for POLR3H Gene

Protein Domains for POLR3H Gene

Suggested Antigen Peptide Sequences for POLR3H Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y535

UniProtKB/Swiss-Prot:

RPC8_HUMAN :
  • Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
Family:
  • Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR3H: view

Function for POLR3H Gene

Molecular function for POLR3H Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Gene Ontology (GO) - Molecular Function for POLR3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003899 DNA-directed RNA polymerase activity IEA,IDA 12391170
genes like me logo Genes that share ontologies with POLR3H: view
genes like me logo Genes that share phenotypes with POLR3H: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR3H Gene

Localization for POLR3H Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR3H Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR3H Gene COMPARTMENTS Subcellular localization image for POLR3H gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for POLR3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR3H: view

Pathways & Interactions for POLR3H Gene

genes like me logo Genes that share pathways with POLR3H: view

Gene Ontology (GO) - Biological Process for POLR3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006383 transcription from RNA polymerase III promoter IDA,TAS 12391170
GO:0006384 transcription initiation from RNA polymerase III promoter IBA --
GO:0032481 positive regulation of type I interferon production TAS --
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with POLR3H: view

No data available for SIGNOR curated interactions for POLR3H Gene

Drugs & Compounds for POLR3H Gene

(5) Drugs for POLR3H Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0

(1) Additional Compounds for POLR3H Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with POLR3H: view

Transcripts for POLR3H Gene

Unigene Clusters for POLR3H Gene

Polymerase (RNA) III (DNA directed) polypeptide H (22.9kD):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLR3H Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - -
SP6: - - - -
SP7: - - - -
SP8: - - - -

Relevant External Links for POLR3H Gene

GeneLoc Exon Structure for
POLR3H
ECgene alternative splicing isoforms for
POLR3H

Expression for POLR3H Gene

mRNA expression in normal human tissues for POLR3H Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR3H Gene

This gene is overexpressed in Heart (42.0) and Testis (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLR3H Gene



SOURCE GeneReport for Unigene cluster for POLR3H Gene Hs.712617

genes like me logo Genes that share expression patterns with POLR3H: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for POLR3H Gene

Orthologs for POLR3H Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR3H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR3H 35
  • 99.51 (n)
  • 100 (a)
POLR3H 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POLR3H 36
  • 96 (a)
OneToOne
POLR3H 35
  • 88.56 (n)
  • 95.1 (a)
dog
(Canis familiaris)
Mammalia POLR3H 35
  • 92.16 (n)
  • 96.57 (a)
POLR3H 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr3h 16
Polr3h 35
  • 89.54 (n)
  • 98.04 (a)
Polr3h 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLR3H 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Polr3h 35
  • 89.71 (n)
  • 98.04 (a)
chicken
(Gallus gallus)
Aves POLR3H 36
  • 88 (a)
OneToOne
POLR3H 35
  • 81.37 (n)
  • 89.22 (a)
lizard
(Anolis carolinensis)
Reptilia POLR3H 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr3h 35
  • 77.29 (n)
  • 88.73 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5767 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13091 35
polr3h 35
  • 75.7 (n)
  • 83.25 (a)
polr3h 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012122 35
  • 62.58 (n)
  • 58.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7339 35
  • 62.96 (n)
  • 60.61 (a)
CG7339 36
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpc-25 36
  • 33 (a)
OneToOne
ZK856.10 35
  • 47.86 (n)
  • 41.03 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR049W 35
  • 52.19 (n)
  • 44.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPC25 35
  • 49.16 (n)
  • 46.46 (a)
RPC25 36
  • 43 (a)
OneToOne
RPC25 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E13751g 35
  • 50.34 (n)
  • 43.43 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06790 35
  • 49.21 (n)
  • 38.74 (a)
rice
(Oryza sativa)
Liliopsida Os07g0477000 35
  • 51.68 (n)
  • 42.33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpc25 35
  • 53 (n)
  • 45 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2134 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToOne
Species with no ortholog for POLR3H:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR3H Gene

ENSEMBL:
Gene Tree for POLR3H (if available)
TreeFam:
Gene Tree for POLR3H (if available)

Paralogs for POLR3H Gene

No data available for Paralogs for POLR3H Gene

Variants for POLR3H Gene

Sequence variations from dbSNP and Humsavar for POLR3H Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs169407 -- 41,539,059(+) cgttc(A/G)agacc intron-variant
rs172150 -- 41,536,121(+) ggcgc(A/G)gtggc intron-variant
rs203313 -- 41,531,801(-) TTCCG(A/G)TTCAC intron-variant
rs203314 -- 41,529,971(-) gagac(C/T)atcct intron-variant
rs5758389 -- 41,545,745(+) ACGCC(C/T)GGCTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for POLR3H Gene

Variant ID Type Subtype PubMed ID
nsv524585 CNV Loss 19592680
nsv516925 CNV Loss 19592680
nsv834208 CNV Loss 17160897

Variation tolerance for POLR3H Gene

Residual Variation Intolerance Score: 44.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR3H Gene

HapMap Linkage Disequilibrium report
POLR3H

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR3H Gene

Disorders for POLR3H Gene

Relevant External Links for POLR3H

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR3H

No disorders were found for POLR3H Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR3H Gene

Publications for POLR3H Gene

  1. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PMID: 12391170) Hu P. … Hernandez N. (Mol. Cell. Biol. 2002) 2 3 4 67
  2. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PMID: 11258795) Hirosawa M. … Ohara O. (DNA Res. 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for POLR3H Gene

Sources for POLR3H Gene

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