Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



POLR3H Gene

protein-coding   GIFtS: 55
GCID: GC22M041921

Polymerase (RNA) III (DNA Directed) Polypeptide H (22.9kD)

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Polymerase (RNA) III (DNA Directed) Polypeptide H (22.9kD)1 2     DNA-Directed RNA Polymerase III Subunit 22.9 KDa Polypeptide2
RPC22.92 3     DNA-Directed RNA Polymerase III Subunit RPC82
RPC82 3     RNA Nucleotidyltransferase (DNA-Directed)2
DNA-Directed RNA Polymerase III Subunit H2 3     KIAA16653
RNA Polymerase III Subunit C82 3     RNA Polymerase III Subunit 22.9 KDa Subunit3

External Ids:    HGNC: 303491   Entrez Gene: 1715682   Ensembl: ENSG000001004137   UniProtKB: Q9Y5353   

Export aliases for POLR3H gene to outside databases

Previous GC identifers: GC22M040166 GC22M040246 GC22M024887


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for POLR3H Gene:
POLR3H (polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)) is a protein-coding gene. GO annotations related to this gene include DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot: RPC8_HUMAN, Q9Y535
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs,
such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA
viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA
that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as
Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the POLR3H gene promoter:
         RP58   CBF-B   CBF-A   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOLR3H promoter sequence
   Search Chromatin IP Primers for POLR3H

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POLR3H


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13

POLR3H Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR3H gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M041921:  view genomic region     (about GC identifiers)

Start:
41,921,803 bp from pter      End:
41,940,610 bp from pter
Size:
18,808 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RPC8_HUMAN, Q9Y535 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase III subunit RPC8  
Size: 204 amino acids; 22918 Da
Subunit: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity).
Interacts with CRCP/RPC9. POLR3H/RPC8 and CRCP/RPC9 probably form a Pol III subcomplex
Sequence caution: Sequence=BAB33335.1; Type=Erroneous initiation;
Secondary accessions: B0QYH9 Q5M7Y8 Q96AE3 Q9BY95
Alternative splicing: 2 isoforms:  Q9Y535-1   Q9Y535-2   

Explore the universe of human proteins at neXtProt for POLR3H: NX_Q9Y535

Explore proteomics data for POLR3H at MOPED


See POLR3H Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (5 alternative transcripts): 
NP_001018060.1  NP_001018062.1  NP_001269813.1  NP_001269814.1  NP_612211.1  

ENSEMBL proteins: 
 ENSP00000347345   ENSP00000337627   ENSP00000395674   ENSP00000415053   ENSP00000385315  
 ENSP00000408083   ENSP00000379761  
Reactome Protein details: Q9Y535

POLR3H Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for POLR3H
OriGene Protein Over-expression Lysate for POLR3H
OriGene MassSpec for POLR3H
OriGene Custom Protein Services for POLR3H
GenScript Custom Purified and Recombinant Proteins Services for POLR3H
Novus Biologicals POLR3H Proteins
Novus Biologicals POLR3H Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for POLR3H
Cloud-Clone Corp. Proteins for POLR3H

 
Search eBioscience for Proteins for POLR3H 

 
antibodies-online proteins for POLR3H (5 products) 

 
antibodies-online peptides for POLR3H

POLR3H Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for POLR3H
OriGene Custom Antibody Services for POLR3H
Novus Biologicals POLR3H Antibodies
Abcam antibodies for POLR3H
Cloud-Clone Corp. Antibodies for POLR3H
ThermoFisher Antibodies for POLR3H
antibodies-online antibodies for POLR3H (21 products) 

POLR3H Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for POLR3H
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for POLR3H
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for POLR3H
Cloud-Clone Corp. CLIAs for POLR3H
Search eBioscience for ELISAs for POLR3H 
antibodies-online kits for POLR3H (6 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
POLR: RNA polymerase subunits

4 InterPro protein domains:
 IPR005576 RNA_pol_Rpb7_N
 IPR013238 RNA_pol_III_Rbc25
 IPR012340 NA-bd_OB-fold
 IPR004519 RNAP_E/RPC8

Graphical View of Domain Structure for InterPro Entry Q9Y535

ProtoNet protein and cluster: Q9Y535

1 Blocks protein domain: IPB005576 RNA polymerase Rpb7

UniProtKB/Swiss-Prot: RPC8_HUMAN, Q9Y535
Similarity: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family


Find genes that share domains with POLR3H           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: RPC8_HUMAN, Q9Y535
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs,
such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA
viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA
that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as
Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By
similarity)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001056contributes to RNA polymerase III activity IBA--
GO:0003677DNA binding IEA--
GO:0003899DNA-directed RNA polymerase activity IDA12391170
     
Find genes that share ontologies with POLR3H           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for POLR3H:
 Small cells 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for POLR3H

miRNA
Products:
    
miRTarBase miRNAs that target POLR3H:
hsa-mir-324-5p (MIRT043160), hsa-mir-423-5p (MIRT038118), hsa-mir-423-3p (MIRT042471), hsa-mir-331-3p (MIRT043433), hsa-mir-615-3p (MIRT039879), hsa-mir-1301-3p (MIRT035985), hsa-mir-30d-5p (MIRT047813), hsa-mir-484 (MIRT042331)

Block miRNA regulation of human, mouse, rat POLR3H using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate POLR3H (see all 12):
hsa-miR-3660 hsa-miR-134 hsa-miR-516b* hsa-miR-542-3p hsa-miR-891b hsa-miR-3118 hsa-miR-2116 hsa-miR-1252
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for POLR3H
Predesigned siRNA for gene silencing in human, mouse, rat POLR3H

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for POLR3H

Clone
Products:
     
OriGene clones in human, mouse for POLR3H (see all 18)
OriGene ORF clones in mouse, rat for POLR3H
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): POLR3H (NM_138338)
Sino Biological Human cDNA Clone for POLR3H
DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLR3H
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR3H

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for POLR3H
Browse ESI BIO Cell Lines and PureStem Progenitors for POLR3H 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR3H


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
RPC8_HUMAN, Q9Y535: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytoskeleton4
cytosol2
mitochondrion2

Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA--
GO:0005654nucleoplasm TAS--
GO:0005666DNA-directed RNA polymerase III complex IDA12391170
GO:0005730NOT nucleolus IDA--
GO:0005813centrosome IDA--

Find genes that share ontologies with POLR3H           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for POLR3H About   (see all 8)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1RNA Polymerase III Transcription Initiation
RNA Polymerase III Transcription Initiation0.88
RNA Polymerase III Transcription Initiation From Type 2 Promoter0.74
RNA Polymerase III Abortive And Retractive Initiation0.88
RNA Polymerase III Transcription Termination0.58
RNA Polymerase III Transcription0.88
RNA polymerase0.45
RNA Polymerase III Transcription Initiation From Type 3 Promoter0.80
RNA Polymerase III Chain Elongation0.00
2Purine metabolism (KEGG)
Purine metabolism0.38
ATP ITP metabolism0.31
Pyrimidine metabolism0.38
3Cytosolic sensors of pathogen-associated DNA
Cytosolic sensors of pathogen-associated DNA0.38
Cytosolic DNA-sensing pathway0.33
4RNA Polymerase I Promoter Opening
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
5Formation of RNA Pol II elongation complex
Eukaryotic Transcription Initiation0.59


Find genes that share SuperPaths with POLR3H           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for POLR3H
    Transcription of tRNA
Assembly of RNA Polymerase-III Initiation Complex

1 GeneGo (Thomson Reuters) Pathway for POLR3H
    ATP/ITP metabolism

1 BioSystems Pathway for POLR3H
    Eukaryotic Transcription Initiation


Selected Reactome Pathways for POLR3H (see all 7)
    RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase III Transcription Initiation From Type 1 Promoter
Cytosolic sensors of pathogen-associated DNA
RNA Polymerase III Chain Elongation
RNA Polymerase III Transcription Termination


Selected Kegg Pathways  (Kegg details for POLR3H) (see all 6):
    Purine metabolism
Pyrimidine metabolism
Metabolic pathways
RNA polymerase
Cytosolic DNA-sensing pathway

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POLR3H
Interactions:

    Search GeneGlobe Interaction Network for POLR3H

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for POLR3H (Q9Y5353 ENSP000003473454) via UniProtKB, MINT, STRING, and/or I2D (see all 169)
InteractantInteraction Details
GeneCardExternal ID(s)
POLR3AO148023, ENSP000003614464I2D: score=6 STRING: ENSP00000361446
RMND5AQ9H8713, ENSP000002836324I2D: score=6 STRING: ENSP00000283632
XPOTO435923, ENSP000003278214I2D: score=6 STRING: ENSP00000327821
POLR1DQ9Y2S03, ENSP000003024784I2D: score=5 STRING: ENSP00000302478
POLR2EP193883, ENSP000002155874I2D: score=5 STRING: ENSP00000215587
About this table

Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006139nucleobase-containing compound metabolic process IDA12391170
GO:0006351transcription, DNA-templated ----
GO:0006383transcription from RNA polymerase III promoter TAS--
GO:0006384transcription initiation from RNA polymerase III promoter IBA--
GO:0006385transcription elongation from RNA polymerase III promoter TAS--

Find genes that share ontologies with POLR3H           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for POLR3H (RPC8)

6 HMDB Compounds for POLR3H    About this table
CompoundSynonyms CAS #PubMed Ids
Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
Guanosine triphosphate5'-GTP (see all 10)86-01-1--
Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
Uridine triphosphate5'-UTP (see all 7)63-39-8--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for POLR3H gene (6 alternative transcripts): 
NM_001018051.1  NM_001018050.3  NM_001018052.3  NM_001282884.1  NM_001282885.1  NM_138338.4  

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000355209(uc003bag.2 uc003bai.2) ENST00000337566 ENST00000431534
ENST00000432789 ENST00000407461 ENST00000442616 ENST00000420561 ENST00000483837(uc003baj.2)
ENST00000396504(uc003baf.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat POLR3H using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate POLR3H (see all 12):
hsa-miR-3660 hsa-miR-134 hsa-miR-516b* hsa-miR-542-3p hsa-miR-891b hsa-miR-3118 hsa-miR-2116 hsa-miR-1252
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for POLR3H
Predesigned siRNA for gene silencing in human, mouse, rat POLR3H
Clone
Products:
     
OriGene clones in human, mouse for POLR3H (see all 18)
OriGene ORF clones in mouse, rat for POLR3H
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): POLR3H (NM_138338)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLR3H
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR3H
Primer
Products:
    
OriGene qPCR primer pairs and template standards for POLR3H
OriGene qSTAR qPCR primer pairs in human, mouse for POLR3H
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POLR3H
  QuantiTect SYBR Green Assays in human, mouse, rat POLR3H
  QuantiFast Probe-based Assays in human, mouse, rat POLR3H

Selected AceView cDNA sequences (see all 265):

BQ441081 BM689178 BU194363 BM681267 BM726622 BM976455 BQ889967 AK000365 
BM707342 CD675584 BE879568 BQ882912 BE408856 AA843583 BI754673 AA678337 
CR621091 CF125453 BM701507 BM661685 BM701610 BQ425412 AI826178 BM013504 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for POLR3H (see all 8)    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c
SP1:        -     -     -     -           -           -     -           -     -                                             
SP2:                                      -           -     -           -     -                                             
SP3:                                      -           -     -     -     -     -                                             
SP4:                                      -           -     -                                                               
SP5:                                      -           -                 -     -                                             


ECgene alternative splicing isoforms for POLR3H

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

POLR3H expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCTGGGTCCT
POLR3H Expression
About this image


POLR3H expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Brain (Nervous System)    fully expand to see all 6 entries
         Cerebral Cortex
 
 Neural Tube (Nervous System)    fully expand to see all 3 entries
         Metencephalon
 
 Gut Tube (Gastrointestinal Tract)
         Foregut
 
 Kidney (Urinary System)
         Metanephros
 
 Eye (Sensory Organs)
         Lens
POLR3H Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

POLR3H Protein Expression
    Custom PCR Arrays for POLR3H
Primer
Products:
OriGene qPCR primer pairs and template standards for POLR3H
OriGene qSTAR qPCR primer pairs in human, mouse for POLR3H
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POLR3H
QuantiTect SYBR Green Assays in human, mouse, rat POLR3H
QuantiFast Probe-based Assays in human, mouse, rat POLR3H
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR3H

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR3H gene from Selected species (see all 23)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Polr3h1 , 5 polymerase (RNA) III (DNA directed) polypeptide H1, 5 89.54(n)1
98.04(a)1
  15 (38.26 cM)5
789291  NM_030229.41  NP_084505.21 
 819150305 
chicken
(Gallus gallus)
Aves POLR3H1 polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) 81.37(n)
89.22(a)
  417990  NM_001277374.1  NP_001264303.1 
lizard
(Anolis carolinensis)
Reptilia POLR3H6
polymerase (RNA) III (DNA directed) polypeptide H ...
88(a)
1 ↔ 1
5(28163022-28169024)
tropical clawed frog
(Xenopus tropicalis)
Amphibia polr3h1 polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) 77.29(n)
88.73(a)
  779851  NM_001078929.1  NP_001072397.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.130912 Transcribed sequence with weak similarity to protein more 79.02(n)    BI881885.1 
fruit fly
(Drosophila melanogaster)
Insecta CG73391 CG7339 62.96(n)
60.61(a)
  39310  NM_001274791.1  NP_001261720.1 
worm
(Caenorhabditis elegans)
Secernentea ZK856.101 ZK856.10 47.86(n)
41.03(a)
  179418  NM_073224.3  NP_505625.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPC25(YKL144C)4
RPC251
RNA polymerase III subunit C25, required for transcription more4
RPC251
49.16(n)1
46.46(a)1
  11(176481-175843)4
8537131, 4  NP_012778.11, 4 
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G067901 AT1G06790 49.21(n)
38.74(a)
  837190  NM_100556.4  NP_172164.1 
rice
(Oryza sativa)
Liliopsida Os07g04770001 Os07g0477000 51.68(n)
42.33(a)
  4343220  NM_001066163.1  NP_001059628.1 


ENSEMBL Gene Tree for POLR3H (if available)
TreeFam Gene Tree for POLR3H (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for POLR3H (see all 388)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1170875991,2
F--41925512(+) GGGCAC/TGCAGC 3 -- int11Minor allele frequency- T:0.01NA 120
rs48220321,2
C,F,A--41925535(+) GACCCT/CTCTCC 3 -- int19Minor allele frequency- C:0.50NA WA CSA EA 368
rs1808703371,2
--41925666(+) CGCATC/TCAACA 3 -- int10--------
rs1444086171,2
C--41925700(+) TTCCCA/CGGAGC 3 -- int10--------
rs1125954041,2
C--41925764(+) TTTTTG/TTTGTT 3 -- int12Minor allele frequency- T:0.05WA NA 122
rs3713288281,2
C--41925767(+) TTGTT-/TTTTTT 3 -- int10--------
rs562609041,2
--41925807(+) CGGGCC/TGGAGT 3 -- int10--------
rs1855274581,2
--41925823(+) GGCACA/GATCTT 3 -- int10--------
rs1905519161,2
--41925842(+) GCAACA/CTCCAC 3 -- int10--------
rs2016978531,2
C--41925862(+) TCACA-/CCATTC 3 -- int10--------

HapMap Linkage Disequilibrium report for POLR3H (41921803 - 41940610 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for POLR3H:    About this table    
Variant IDTypeSubtypePubMed ID
nsv834208CNV Loss17160897
nsv516925CNV Loss19592680
nsv524585CNV Loss19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing POLR3H
DNA2.0 Custom Variant and Variant Library Synthesis for POLR3H

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for POLR3H gene, integrated from 10 sources (see all 22):
(articles sorted by number of sources associating them with POLR3H)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PubMed id 12391170)1, 2, 3 Hu P....Hernandez N. (Mol. Cell. Biol. 2002)
  2. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PubMed id 11258795)1, 2, 3 Hirosawa M.... Ohara O. (DNA Res. 2001)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
  5. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
  6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
  8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
  9. Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factors. (PubMed id 20843307)1 Owen T.J....Arrand J.R. (Mol. Cancer 2010)
  10. The hepatitis delta virus RNA genome interacts with the human RNA polymerases I and III. (PubMed id 19246067)1 Greco-Stewart V.S....Pelchat M. (Virology 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 171568 HGNC: 30349 AceView: POLR3H Ensembl:ENSG00000100413 euGenes: HUgn171568
ECgene: POLR3H Kegg: 171568 H-InvDB: POLR3H

(According to HUGE)
About This Section

TryGeneCards Plus
HUGE: KIAA1665

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for POLR3H Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for POLR3H gene:
Search GeneIP for patents involving POLR3H

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for POLR3H   OriGene RNAi products in human, mouse, rat for POLR3H  
 OriGene qPCR primer pairs and template standards for POLR3H   OriGene Protein Over-expression Lysate for POLR3H  
 OriGene MassSpec for POLR3H   OriGene clones in human, mouse for POLR3H  
 OriGene qSTAR qPCR primer pairs in human, mouse for POLR3H   OriGene Purified Protein for POLR3H  
 OriGene ORF clones in mouse, rat for POLR3H   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for POLR3H   OriGene Custom Protein Services for POLR3H  

 
 
 Block miRNA regulation of human, mouse, rat POLR3H using miScript Target Protectors SeqTarget long-range PCR primers for resequencing POLR3H
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POLR3H Predesigned siRNA for gene silencing in human, mouse, rat POLR3H
 QuantiFast Probe-based Assays in human, mouse, rat POLR3H QuantiTect SYBR Green Assays in human, mouse, rat POLR3H
 Custom PCR Arrays for POLR3H Search Chromatin IP Primers for POLR3H
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POLR3H  Search GeneGlobe Interaction Network for POLR3H
 Regulatory tfbs in POLR3H promoter
 GenScript Custom Purified and Recombinant Proteins Services for POLR3H GenScript cDNA clones with any tag delivered in your preferred vector for POLR3H
 GenScript Custom Assay Services for POLR3H GenScript Custom overexpressing Cell Line Services for POLR3H
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for POLR3H (RPC8)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 cDNA Clones for POLR3H
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 POLR3H antibodies
 POLR3H proteins
 POLR3H lysates
 Antibodies for POLR3H
 See all of Abcam's Antibodies, Kits and Proteins for POLR3H
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for POLR3H
 Proteins for POLR3H
 Antibodies for POLR3H
 ELISAs for POLR3H
 CLIAs for POLR3H



 Browse ESI BIO Cell Lines and PureStem Progenitors for POLR3H
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR3H
 Browse SwitchGear 3'UTR luciferase reporter plasmids for POLR3H
 SwitchGear Promoter luciferase reporter plasmids for POLR3H
 ThermoFisher Antibodies for POLR3H
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR3H
 Browse compounds at ApexBio
 Search Addgene for plasmids for POLR3H
  Search eBioscience for proteins for POLR3H
  Search eBioscience for elisas for POLR3H
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for POLR3H
 antibodies-online antibodies for POLR3H (21 products)
 antibodies-online kits for POLR3H (6 products)
 antibodies-online peptides for POLR3H
 antibodies-online proteins for POLR3H (5 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      POLR3H gene at Home site.
Version: 3.12.258 10 Dec 2014
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4