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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POLR3H Gene

protein-coding   GIFtS: 58
GCID: GC22M041921

Polymerase (RNA) III (DNA Directed) Polypeptide H (22.9kD)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Polymerase (RNA) III (DNA Directed) Polypeptide H (22.9kD)1 2     DNA-Directed RNA Polymerase III Subunit 22.9 KDa Polypeptide2
RPC22.92 3     DNA-Directed RNA Polymerase III Subunit RPC82
RPC82 3     RNA Nucleotidyltransferase (DNA-Directed)2
DNA-Directed RNA Polymerase III Subunit H2 3     KIAA16653
RNA Polymerase III Subunit C82 3     RNA Polymerase III Subunit 22.9 KDa Subunit3

External Ids:    HGNC: 303491   Entrez Gene: 1715682   Ensembl: ENSG000001004137   UniProtKB: Q9Y5353   

Export aliases for POLR3H gene to outside databases

Previous GC identifers: GC22M040166 GC22M040246 GC22M024887


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for POLR3H Gene: 
POLR3H (polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)) is a protein-coding gene. Diseases associated with POLR3H include intrahepatic cholangiocarcinoma, and cholangiocarcinoma, and among its related super-pathways are RNA Polymerase III Transcription Initiation and Purine metabolism. GO annotations related to this gene include DNA-directed RNA polymerase activity and DNA binding.

UniProtKB/Swiss-Prot: RPC8_HUMAN, Q9Y535
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs,
such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA
viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA
that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as
Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POLR3H gene promoter:
         RP58   CBF-B   CBF-A   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOLR3H promoter sequence
   Search SABiosciences Chromatin IP Primers for POLR3H

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLR3H


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13

POLR3H Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR3H gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M041921:  view genomic region     (about GC identifiers)

Start:
41,921,803 bp from pter      End:
41,940,610 bp from pter
Size:
18,808 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RPC8_HUMAN, Q9Y535 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase III subunit RPC8  
Size: 204 amino acids; 22918 Da
Subunit: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity).
Interacts with CRCP/RPC9. POLR3H/RPC8 and CRCP/RPC9 probably form a Pol III subcomplex
Subcellular location: Nucleus
Sequence caution: Sequence=BAB33335.1; Type=Erroneous initiation;
Secondary accessions: B0QYH9 Q5M7Y8 Q96AE3 Q9BY95
Alternative splicing: 2 isoforms:  Q9Y535-1   Q9Y535-2   

Explore the universe of human proteins at neXtProt for POLR3H: NX_Q9Y535

Explore proteomics data for POLR3H at MOPED 

POLR3H Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

POLR3H Protein Expression

REFSEQ proteins (5 alternative transcripts): 
NP_001018060.1  NP_001018062.1  NP_001269813.1  NP_001269814.1  NP_612211.1  

ENSEMBL proteins: 
 ENSP00000347345   ENSP00000337627   ENSP00000395674   ENSP00000415053   ENSP00000385315  
 ENSP00000408083   ENSP00000379761  
Reactome Protein details: Q9Y535
Human Recombinant Protein Products for POLR3H: 
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Cloud-Clone Corp. Proteins for POLR3H 

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA--
GO:0005654nucleoplasm TAS--
GO:0005666DNA-directed RNA polymerase III complex IDA12391170
GO:0005730NOT nucleolus IDA--
GO:0005813centrosome IDA--

POLR3H for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for POLR3H


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
POLR: RNA polymerase subunits

4 InterPro protein domains:
 IPR005576 RNA_pol_Rpb7_N
 IPR013238 RNA_pol_III_Rbc25
 IPR012340 NA-bd_OB-fold
 IPR004519 RNAP_E/RPC8

Graphical View of Domain Structure for InterPro Entry Q9Y535

ProtoNet protein and cluster: Q9Y535

1 Blocks protein domain: IPB005576 RNA polymerase Rpb7

UniProtKB/Swiss-Prot: RPC8_HUMAN, Q9Y535
Similarity: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family


POLR3H for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: RPC8_HUMAN, Q9Y535
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs,
such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA
viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA
that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as
Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By
similarity)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0003899DNA-directed RNA polymerase activity IDA12391170
     
POLR3H for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for POLR3H:
 Small cells 

Animal Models:
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR3H


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for POLR3H About   (see all 9)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1RNA Polymerase III Transcription Initiation
RNA Polymerase III Transcription Initiation0.80
RNA Polymerase III Transcription Initiation From Type 2 Promoter0.74
RNA Polymerase III Transcription0.80
RNA Polymerase III Chain Elongation0.69
RNA Polymerase III Abortive And Retractive Initiation0.80
RNA Polymerase III Transcription Termination0.69
RNA Polymerase III Transcription Initiation From Type 3 Promoter0.80
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.59
2Purine metabolism
Purine metabolism0.38
ATP/ITP metabolism0.31
Pyrimidine metabolism0.38
3Cytosolic DNA-sensing pathway
Cytosolic DNA-sensing pathway0.36
Cytosolic sensors of pathogen-associated DNA 0.36
4Immune System
Immune System0.56
Innate Immune System0.50
5Transcription
Transcription0.69

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for POLR3H
    ATP/ITP metabolism


1 GeneGo (Thomson Reuters) Pathway for POLR3H
    ATP/ITP metabolism

1 BioSystems Pathway for POLR3H
    Eukaryotic Transcription Initiation

5/14        Reactome Pathways for POLR3H (see all 14)
    RNA Polymerase III Transcription Initiation
RNA Polymerase III Transcription Initiation From Type 3 Promoter
Cytosolic sensors of pathogen-associated DNA
RNA Polymerase III Chain Elongation
Transcription


5/6         Kegg Pathways  (Kegg details for POLR3H) (see all 6):
    Purine metabolism
Pyrimidine metabolism
Metabolic pathways
RNA polymerase
Cytosolic DNA-sensing pathway


POLR3H for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POLR3H

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/134 Interacting proteins for POLR3H (Q9Y5353 ENSP000003473454) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
InteractantInteraction Details
GeneCardExternal ID(s)
POLR3AO148023, ENSP000003614464I2D: score=6 STRING: ENSP00000361446
POLR1DQ9Y2S03, ENSP000003024784I2D: score=5 STRING: ENSP00000302478
POLR2EP193883, ENSP000002155874I2D: score=5 STRING: ENSP00000215587
POLR2HP524343, ENSP000002962234I2D: score=2 STRING: ENSP00000296223
CHMP243863, ENSP000003503864I2D: score=1 STRING: ENSP00000350386
About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006139nucleobase-containing compound metabolic process IDA12391170
GO:0006351transcription, DNA-dependent ----
GO:0006383transcription from RNA polymerase III promoter TAS--
GO:0006385transcription elongation from RNA polymerase III promoter TAS--
GO:0006386termination of RNA polymerase III transcription TAS--

POLR3H for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
EMD Millipore small molecules for POLR3H:
Small Molecule - inhibitor
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6 HMDB Compounds for POLR3H    About this table
CompoundSynonyms CAS #PubMed Ids
Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
Guanosine triphosphate5'-GTP (see all 10)86-01-1--
Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
Uridine triphosphate5'-UTP (see all 7)63-39-8--

Search CenterWatch for drugs/clinical trials and news about POLR3H / RPC8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for POLR3H gene (6 alternative transcripts): 
NM_001018051.1  NM_001018050.3  NM_001018052.3  NM_001282884.1  NM_001282885.1  NM_138338.4  

Unigene Cluster for POLR3H:

Polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)
Hs.712617  [show with all ESTs]
Unigene Representative Sequence: NM_001018050
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000355209(uc003bag.2 uc003bai.2) ENST00000337566 ENST00000431534
ENST00000432789 ENST00000407461 ENST00000442616 ENST00000420561 ENST00000483837(uc003baj.2)
ENST00000396504(uc003baf.3)
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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hsa-miR-3660 hsa-miR-134 hsa-miR-516b* hsa-miR-542-3p hsa-miR-891b hsa-miR-3118 hsa-miR-2116 hsa-miR-1252
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Additional mRNA sequence: 

AB051452.1 AK000365.1 AK026524.1 AY092087.1 BC017248.2 BC088367.1 CR456459.1 

24/27 DOTS entries (see all 27):

DT.441790  DT.100891511  DT.420057  DT.100693946  DT.97820748  DT.95195997  DT.97855761  DT.100770631 
DT.100891535  DT.100891522  DT.120673851  DT.99951822  DT.100891526  DT.92457677  DT.100891506  DT.100891541 
DT.40316524  DT.97770078  DT.97855759  DT.100026962  DT.100700086  DT.100891505  DT.100891530  DT.120673937 

24/265 AceView cDNA sequences (see all 265):

BU738676 BM797372 BE408856 BM673456 BM661685 BF934817 BM800565 H45170 
BQ425412 AA134095 BU147249 BM707342 AA661740 CF125453 AK000365 BM013504 
H51364 BM701610 BM473852 AI948637 BE879568 CD675584 BC017248 BE897218 

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for POLR3H (see all 8)    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c
SP1:        -     -     -     -           -           -     -           -     -                                             
SP2:                                      -           -     -           -     -                                             
SP3:                                      -           -     -     -     -     -                                             
SP4:                                      -           -     -                                                               
SP5:                                      -           -                 -     -                                             


ECgene alternative splicing isoforms for POLR3H

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

POLR3H expression in normal human tissues (normalized intensities)      POLR3H embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCTGGGTCCT
POLR3H Expression
About this image


POLR3H expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/21 selected tissues (see all 21) fully expand
 
 Brain (Nervous System)    fully expand to see all 9 entries
         Thalamus
         brain/midbrain   
 
 Neural Tube (Nervous System)    fully expand to see all 3 entries
         Metencephalon
 
 Heart (Cardiovascular System)    fully expand to see all 2 entries
         heart/atrium   
 
 Limb (Muscoskeletal System)    fully expand to see all 2 entries
         limb/hindlimb   
 
 Gut Tube (Gastrointestinal Tract)
         Foregut

See POLR3H Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POLR3H

SOURCE GeneReport for Unigene cluster: Hs.712617
    SABiosciences Custom PCR Arrays for POLR3H
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for POLR3H gene from 7/20 species (see all 20)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Polr3h1 , 5 polymerase (RNA) III (DNA directed) polypeptide H1, 5 89.54(n)1
98.04(a)1
  15 (38.26 cM)5
789291  NM_030229.41  NP_084505.21 
 819150305 
chicken
(Gallus gallus)
Aves POLR3H1 polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) 81.37(n)
89.22(a)
  417990  XM_416229.3  XP_416229.2 
lizard
(Anolis carolinensis)
Reptilia POLR3H6
Uncharacterized protein
88(a)
1 ↔ 1
5(28163022-28169024)
zebrafish
(Danio rerio)
Actinopterygii Dr.130912 Transcribed sequence with weak similarity to protein more 79.02(n)    BI881885.1 
fruit fly
(Drosophila melanogaster)
Insecta CG73391 CG7339 60.86(n)
58.71(a)
  39310  NM_140233.1  NP_648490.1 
worm
(Caenorhabditis elegans)
Secernentea ZK856.101 Protein ZK856.10 48.45(n)
41.24(a)
  179418  NM_073224.2  NP_505625.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPC25(YKL144C)4
RPC251
RNA polymerase III subunit C25, required for transcription more4
Rpc25p1
49.33(n)1
46.46(a)1
  11(176481-175843)4
8537131, 4  NP_012778.11, 4 


ENSEMBL Gene Tree for POLR3H (if available)
TreeFam Gene Tree for POLR3H (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/388 SNPs in POLR3H are shown (see all 388)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1170875991,2
F--41925512(+) GGGCAC/TGCAGC 3 -- int11Minor allele frequency- T:0.01NA 120
rs48220321,2
C,F,A--41925535(+) GACCCT/CTCTCC 3 -- int19Minor allele frequency- C:0.50NA WA CSA EA 368
rs1808703371,2
--41925666(+) CGCATC/TCAACA 3 -- int10--------
rs1444086171,2
C--41925700(+) TTCCCA/CGGAGC 3 -- int10--------
rs1125954041,2
C--41925764(+) TTTTTG/TTTGTT 3 -- int12Minor allele frequency- T:0.05WA NA 122
rs3713288281,2
C--41925767(+) TTGTT-/TTTTTT 3 -- int10--------
rs562609041,2
--41925807(+) CGGGCC/TGGAGT 3 -- int10--------
rs1855274581,2
--41925823(+) GGCACA/GATCTT 3 -- int10--------
rs1905519161,2
--41925842(+) GCAACA/CTCCAC 3 -- int10--------
rs2016978531,2
C--41925862(+) TCACA-/CCATTC 3 -- int10--------

HapMap Linkage Disequilibrium report for POLR3H (41921803 - 41940610 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for POLR3H:    About this table     
Variant IDTypeSubtypePubMed ID
nsv834208CNV Loss17160897
nsv516925CNV Loss19592680
nsv524585CNV Loss19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
3 diseases for POLR3H:    About MalaCards
intrahepatic cholangiocarcinoma    cholangiocarcinoma    hepatitis


POLR3H for disorders           About GeneDecksing


Export disorders for POLR3H gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for POLR3H gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with POLR3H)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PubMed id 12391170)1, 2, 3 Hu P....Hernandez N. (2002)
  2. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PubMed id 11258795)1, 2, 3 Hirosawa M....Ohara O. (2001)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
  5. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
  6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
  7. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
  8. Epstein-Barr virus-encoded EBNA1 enhances RNA polymer ase III-dependent EBER expression through induction of EBER-associated cellular transcription factors. (PubMed id 20843307)1 Owen T.J....Arrand J.R. (2010)
  9. The hepatitis delta virus RNA genome interacts with the human RNA polymerases I and III. (PubMed id 19246067)1 Greco-Stewart V.S....Pelchat M. (2009)
  10. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
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  Query String
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 171568 HGNC: 30349 AceView: POLR3H Ensembl:ENSG00000100413 euGenes: HUgn171568
ECgene: POLR3H Kegg: 171568 H-InvDB: POLR3H

(According to HUGE)
About This Section
HUGE: KIAA1665

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for POLR3H Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for POLR3H gene:
Search GeneIP for patents involving POLR3H

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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