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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POLR3G Gene

protein-coding   GIFtS: 53
GCID: GC05P089807

polymerase (RNA) III (DNA directed) polypeptide G (32kD)
 Explore 6 diseases affiliated with
POLR3G via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for POLR3G    

Aliases
for POLR3G gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Polymerase (RNA) III (DNA Directed) Polypeptide G (32kD)1 2     RNA Polymerase III 32 KDa Subunit2 3
RPC321 2 3     RNA Polymerase III Subunit C72 3
RPC71 2     DNA-Directed RNA Polymerase III 32 KDa Polypeptide2
DNA-Directed RNA Polymerase III Subunit G2 3     DNA-Directed RNA Polymerase III Subunit RPC72

External Ids:    HGNC: 300751   Entrez Gene: 106222   Ensembl: ENSG000001133567   UniProtKB: O153183   

Export aliases for POLR3G gene to outside databases

Previous GC identifers: GC05P089854 GC05P084981


Summaries
for POLR3G gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: RPC7_HUMAN, O15318
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as
5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III
binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the
recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of
other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA
viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that
serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr
virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway




Genomic Views
for POLR3G gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POLR3G gene promoter:
         Egr-3   Max1   AML1a   LCR-F1   HNF-1A   Arnt   MEF-2A   HNF-1   aMEF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: POLR3G promoter sequence
   Search SABiosciences Chromatin IP Primers for POLR3G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLR3G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14.3   Ensembl cytogenetic band:  5q14.3   HGNC cytogenetic band: 5q14

POLR3G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR3G gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P089807:  view genomic region     (about GC identifiers)

Start:
 89,767,565 bp from pter      End:
 89,810,370 bp from pter
Size:
 42,806 bases      Orientation:
 plus strand

Proteins
for POLR3G gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RPC7_HUMAN, O15318 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase III subunit RPC7  
Size: 223 amino acids; 25914 Da
Subunit: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). RPC3/POLR3C,
RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAB63676.1; Type=Frameshift; Positions=214;
Secondary accessions: A8MTH0

Explore the universe of human proteins at neXtProt for POLR3G: NX_O15318

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15318

    • POLR3G Protein expression data from MOPED and PaxDb:    About this image 
    POLR3G Protein Expression
    REFSEQ proteins: NP_006458.2  
    ENSEMBL proteins: 
     ENSP00000424970   ENSP00000427412   ENSP00000422892   ENSP00000422164   ENSP00000421637  
     ENSP00000425617   ENSP00000382058  
    Reactome Protein details: O15318
    Human Recombinant Protein Products for POLR3G: 
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    Browse R&D Systems for human recombinant proteins
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: POLR3G
    OriGene Custom Protein Services for POLR3G 
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    Novus Biologicals POLR3G Protein
    Novus Biologicals POLR3G Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for POLR3G

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005666DNA-directed RNA polymerase III complex TAS9171375

    POLR3G for ontologies           About GeneDecksing



    POLR3G Antibody Products: 
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    Abcam antibodies for POLR3G 
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    Assay Products for POLR3G: 
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    Uscn ELISAs and CLIAs for POLR3G

    Protein Domains /
    Families
    for POLR3G gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    POLR3G for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR024661 RNA_pol_III_Rpc31

    Graphical View of Domain Structure for InterPro Entry O15318

    ProtoNet protein and cluster: O15318

    UniProtKB/Swiss-Prot: RPC7_HUMAN, O15318
    Similarity: Belongs to the eukaryotic RPC7 RNA polymerase subunit family


    Function
    for POLR3G gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPC7_HUMAN, O15318
    Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
    triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as
    5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III
    binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the
    recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of
    other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA
    viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that
    serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr
    virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003899DNA-directed RNA polymerase activity IEA--
         
    POLR3G for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for POLR3G:
     Decreased Hepatitis C virus re  Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for POLR3G 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: POLR3G
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLR3G
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate POLR3G (see all 53):
    hsa-miR-520e hsa-miR-302d hsa-miR-361-5p hsa-miR-631 hsa-miR-106a hsa-miR-30d hsa-miR-342-3p hsa-miR-183*
    SwitchGear 3'UTR luciferase reporter plasmid: POLR3G 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLR3G (see all 7)
    OriGene shRNA RFP: POLR3G
    OriGene siRNA: POLR3G
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLR3G
    Sirion Biotech Custom design and validation of potent shRNA sequences against POLR3G 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for POLR3G
    Sirion Biotech Customized adenovirus for overexpression of POLR3G 
    Sirion Biotech Customized adenovirus for potent knockdown of POLR3G

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLR3G (see all 4)
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    GenScript: all cDNA clones in your preferred vector: POLR3G (NM_006467)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR3G 

    Cell Line
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    Search LifeMap BioReagents cell lines for POLR3G
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    Sirion Biotech Customized inducible overexpressing cell line services for POLR3G

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR3G


    Pathways & Interactions
    for POLR3G gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1RNA Polymerase III Transcription Initiation
    8/10 pathways (see all 10)
    		RNA Polymerase III Transcription Initiation1.00
    		RNA Polymerase III Transcription Initiation From Type 2 Promoter0.74
    		RNA Polymerase III Abortive And Retractive Initiation1.00
    		RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.59
    		RNA Polymerase III Transcription1.00
    		RNA Polymerase III Chain Elongation0.51
    		RNA Polymerase III Transcription Initiation From Type 3 Promoter0.80
    		RNA Polymerase III Transcription Termination0.51
    2ATP/ITP metabolism
    		ATP/ITP metabolism1.00
    		ATP/ITP metabolism0.98
    3Purine metabolism
    		Purine metabolism1.00
    		Pyrimidine metabolism0.38
    4Transcription
    		Transcription1.00
    5Cytosolic DNA-sensing pathway
    		Cytosolic DNA-sensing pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for POLR3G
        ATP/ITP metabolism


    1 GeneGo (Thomson Reuters) Pathway for POLR3G
        ATP/ITP metabolism

    5/11        Reactome Pathways for POLR3G (see all 11)
        RNA Polymerase III Transcription Initiation
    RNA Polymerase III Transcription Initiation From Type 3 Promoter
    RNA Polymerase III Chain Elongation
    Transcription
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription


    5         Kegg Pathways  (Kegg details for POLR3G):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways
    RNA polymerase
    Cytosolic DNA-sensing pathway


    POLR3G for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POLR3G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/76 Interacting proteins for POLR3G (O153183 ENSP000003820584) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR3CQ9BUI43, ENSP000003345644I2D: score=1 STRING: ENSP00000334564
    POLR3DP054233, ENSP000003030884I2D: score=1 STRING: ENSP00000303088
    POLR3HQ9Y5353, ENSP000003473454I2D: score=1 STRING: ENSP00000347345
    POLR3FQ9H1D93, ENSP000003668284I2D: score=1 STRING: ENSP00000366828
    GTF3AENSP000003705324STRING: ENSP00000370532
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006359regulation of transcription from RNA polymerase III promoter TAS9171375
    GO:0006383transcription from RNA polymerase III promoter TAS--
    GO:0006385transcription elongation from RNA polymerase III promoter TAS--
    GO:0006386termination of RNA polymerase III transcription TAS--
    GO:0009615response to virus ----

    POLR3G for ontologies           About GeneDecksing



    Drugs & Compounds
    for POLR3G gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for POLR3G:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POLR3G

    4 HMDB Compounds for POLR3G    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Uridine triphosphate5'-UTP (see all 7)63-39-8--
    Search CenterWatch for drugs/clinical trials and news about POLR3G / RPC7 

    Transcripts
    for POLR3G gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for POLR3G gene: 
    NM_006467.2  

    Unigene Cluster for POLR3G:

    Polymerase (RNA) III (DNA directed) polypeptide G (32kD)
    Hs.282387  [show with all ESTs]
    Unigene Representative Sequence: NM_006467
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512239 ENST00000505345 ENST00000503373 ENST00000503973 ENST00000504930
    ENST00000514483 ENST00000399107(uc003kjq.3 uc011cuc.2)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: POLR3G
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLR3G
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate POLR3G (see all 53):
    hsa-miR-520e hsa-miR-302d hsa-miR-361-5p hsa-miR-631 hsa-miR-106a hsa-miR-30d hsa-miR-342-3p hsa-miR-183*
    SwitchGear 3'UTR luciferase reporter plasmid: POLR3G 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLR3G (see all 7)
    OriGene shRNA RFP: POLR3G
    OriGene siRNA: POLR3G
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLR3G
    Sirion Biotech Custom design and validation of potent shRNA sequences against POLR3G 
    Clone
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    GenScript: all cDNA clones in your preferred vector: POLR3G (NM_006467)
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POLR3G
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR3G
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR3G

    Additional cDNA sequence: 

    AK025490.1 AK295434.1 U93868.1 

    3 DOTS entries:

    DT.206092  DT.91954723  DT.120799941 

    24/31 AceView cDNA sequences (see all 31):

    AW449940 AI081797 BQ229558 AA418505 BP364736 BG771119 BQ182945 BI856695 
    BQ940162 AW237234 BX280440 CB243971 BG771038 AK025490 BF056239 AA927507 
    BP348952 AA418408 BE958385 NM_006467 BI859872 U93868 AA194083 BG203495 

    GeneLoc Exon Structure


    Expression
    for POLR3G gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POLR3G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCAAAACTG
    POLR3G Expression
    About this image

    POLR3G expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Matrigel embedded cells (Derivation of cardio...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See POLR3G Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POLR3G

    SOURCE GeneReport for Unigene cluster: Hs.282387
        SABiosciences Custom PCR Arrays for POLR3G
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR3G

    Orthologs
    for POLR3G gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for POLR3G gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Polr3g1 , 5 polymerase (RNA) III (DNA directed) polypeptide G1, 5 83.63(n)1
    83.33(a)1    		   13 (43.68 cM)5
    674861  NM_001081176.11  NP_001074645.11 
     816738435 
    chicken
    (Gallus gallus)    		 Aves POLR3G1 polymerase (RNA) III (DNA directed) polypeptide G (32kD) less 74.96(n)
    69.01(a)    		   427105  XM_424697.2  XP_424697.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1000009781 novel protein similar to vertebrate polymerase (RNA) III (DNA directed) polypeptide G (32kD) (POLR3G) less 63.8(n)
    55.02(a)    		   100000978  NM_001126469.1  NP_001119941.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG330511 CG33051 47.1(n)
    32.84(a)    		   39941  NM_176344.2  NP_788522.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_Y47G6A.91 Protein Y47G6A.9 51.49(n)
    34.65(a)    		   171916  NM_058766.2  NP_491167.1 


    ENSEMBL Gene Tree for POLR3G (if available)
    TreeFam Gene Tree for POLR3G (if available) 

    Paralogs
    for POLR3G gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POLR3G gene
    POLR3GL2  
    1 SIMAP similar gene for POLR3G using alignment to 7 protein entries:     RPC7_HUMAN (see all proteins):
    POLR3GL

    POLR3G for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for POLR3G
    PGOHUM00000250113 PGOHUM00000249934


    Genomic Variants
    for POLR3G gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/602 NCBI SNPs in POLR3G are shown (see all 602)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1145887591,2
    		C,F--84979742(+) AAGAAC/AAGAAA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs803469741,2
    		C--84979935(+) CTACGA/GAAGCT 1 -- int12Minor allele frequency- G:0.02NA 122
    rs104743261,2
    		C,F,H--84979996(+) AGTCAC/TAAGTC 1 -- int111Minor allele frequency- T:0.08NS EA NA CSA WA 1308
    rs117498081,2
    		C,F,A,H--84980251(+) ACAGTC/GTCTTC 1 -- int14Minor allele frequency- G:0.01NS EA 418
    rs1147497271,2
    		C,F--84981206(+) GCTGGC/AGCAGA 1 -- ut511Minor allele frequency- A:0.07WA 118
    rs757655711,2
    		F--84981296(+) CCTTCC/TTAGGG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs737712671,2
    		C--84981366(+) TGCGCC/GCTTCT 1 -- us2k11Minor allele frequency- G:0.00WA 2
    rs168686731,2
    		C,F,H--84981848(+) TTTTCG/CTAACT 1 -- us2k114Minor allele frequency- C:0.08NA NS EA WA 1684
    rs125196711,2
    		C,F,H--84982602(+) CTGTGA/TCAACT 1 -- us2k14Minor allele frequency- T:0.02NA 260
    rs29146731,2
    		C,F,O,A,H--84982612(-) GCTTAT/CTAGTA 1 -- us2k121Minor allele frequency- C:0.07EA NS NA WA CSA 3855

    HapMap Linkage Disequilibrium report for POLR3G (89767565 - 89810370 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for POLR3G: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for POLR3G gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    POLR3G for disorders           About GeneDecksing

    6 diseases for POLR3G:    About MalaCards
    capillary leak syndrome    juvenile myelomonocytic leukemia    myelomonocytic leukemia    pneumonia
    immunodeficiency    leukemia


    Export disorders for POLR3G gene to outside databases

    Publications
    for POLR3G gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POLR3G gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with POLR3G)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PubMed id 12391170)1, 2, 3 Hu P....Hernandez N. (2002)
    2. Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation. (PubMed id 9171375)1, 2, 3 Wang Z. and Roeder R.G. (1997)
    3. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. (PubMed id 19631370)1, 2 Chiu Y.-H.... Chen Z.J. (2009)
    4. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. (PubMed id 19609254)1, 2 Ablasser A....Hornung V. (2009)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells. (PubMed id 21898682)1 Wong R.C....Donovan P.J. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash. (PubMed id 21810746)1 Chantarangsu S....Nakamura Y. (2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)

    External Searches for POLR3G gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing POLR3G gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10622 HGNC: 30075 AceView: POLR3G Ensembl:ENSG00000113356 euGenes: HUgn10622
    ECgene: POLR3G Kegg: 10622 H-InvDB: POLR3G

    Other Databases showing POLR3G gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing POLR3G gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POLR3G Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for POLR3G gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for POLR3G gene:
    Search GeneIP for patents involving POLR3G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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