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Aliases for POLR3G Gene

Aliases for POLR3G Gene

  • RNA Polymerase III Subunit G 2 3 5
  • Polymerase (RNA) III (DNA Directed) Polypeptide G (32kD) 2 3
  • DNA-Directed RNA Polymerase III Subunit G 3 4
  • RNA Polymerase III 32 KDa Subunit 3 4
  • RNA Polymerase III Subunit C7 3 4
  • RPC32 3 4
  • DNA-Directed RNA Polymerase III 32 KDa Polypeptide 3
  • DNA-Directed RNA Polymerase III Subunit RPC7 3
  • Polymerase (RNA) III Subunit G 3
  • RPC7 3

External Ids for POLR3G Gene

Previous GeneCards Identifiers for POLR3G Gene

  • GC05P089854
  • GC05P089807
  • GC05P084981

Summaries for POLR3G Gene

GeneCards Summary for POLR3G Gene

POLR3G (RNA Polymerase III Subunit G) is a Protein Coding gene. Diseases associated with POLR3G include Leukemia, Acute Myelomonocytic, Somatic, Somatic. Among its related pathways are Innate Immune System and RNA Polymerase III Transcription Initiation. GO annotations related to this gene include DNA-directed 5-3 RNA polymerase activity and RNA polymerase III activity. An important paralog of this gene is POLR3GL.

UniProtKB/Swiss-Prot for POLR3G Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR3G Gene

Genomics for POLR3G Gene

Regulatory Elements for POLR3G Gene

Enhancers for POLR3G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G090558 1.5 Ensembl ENCODE dbSUPER 9.1 +86.9 86939 1.5 SIN3A ZNF2 ZBTB7B ZNF263 SP3 REST ZNF579 SREBF1 CBX8 ZNF610 POLR3G LYSMD3 LOC105379077
GH05G090604 1.2 Ensembl ENCODE 11 +133.3 133286 0.6 PKNOX1 ATF1 CREB3L1 ARNT ELK1 FOS REST ZNF592 MEF2D CREB3 POLR3G LYSMD3 LOC105379077
GH05G090439 1.1 Ensembl ENCODE 11.5 -31.7 -31672 1.0 CTCF ZNF384 CHD7 ZNF644 RAD21 YY1 ZNF366 SMC3 HES1 ZNF639 LYSMD3 ADGRV1 POLR3G MBLAC2 CETN3 LOC731157
GH05G090527 1.1 ENCODE 11 +57.7 57729 3.2 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 POLR3G ADGRV1 LYSMD3
GH05G090472 1.4 Ensembl ENCODE 7.3 +3.7 3749 5.5 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR3G MBLAC2 ADGRV1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLR3G on UCSC Golden Path with GeneCards custom track

Genomic Location for POLR3G Gene

Chromosome:
5
Start:
90,471,748 bp from pter
End:
90,514,677 bp from pter
Size:
42,930 bases
Orientation:
Plus strand

Genomic View for POLR3G Gene

Genes around POLR3G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR3G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR3G Gene

Proteins for POLR3G Gene

  • Protein details for POLR3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15318-RPC7_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC7
    Protein Accession:
    O15318
    Secondary Accessions:
    • A8MTH0

    Protein attributes for POLR3G Gene

    Size:
    223 amino acids
    Molecular mass:
    25914 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex.
    SequenceCaution:
    • Sequence=AAB63676.1; Type=Frameshift; Positions=214; Evidence={ECO:0000305};

neXtProt entry for POLR3G Gene

Post-translational modifications for POLR3G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for POLR3G Gene

Domains & Families for POLR3G Gene

Gene Families for POLR3G Gene

Protein Domains for POLR3G Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for POLR3G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15318

UniProtKB/Swiss-Prot:

RPC7_HUMAN :
  • Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
Family:
  • Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR3G: view

Function for POLR3G Gene

Molecular function for POLR3G Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Gene Ontology (GO) - Molecular Function for POLR3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003899 DNA-directed 5-3 RNA polymerase activity TAS,IEA --
genes like me logo Genes that share ontologies with POLR3G: view
genes like me logo Genes that share phenotypes with POLR3G: view

Animal Models for POLR3G Gene

MGI Knock Outs for POLR3G:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POLR3G Gene

Localization for POLR3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR3G Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR3G gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for POLR3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 colocalizes_with nuclear chromatin IDA 24107381
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005666 DNA-directed RNA polymerase III complex IDA,TAS 24107381
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR3G: view

Pathways & Interactions for POLR3G Gene

genes like me logo Genes that share pathways with POLR3G: view

Gene Ontology (GO) - Biological Process for POLR3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006359 regulation of transcription from RNA polymerase III promoter TAS 9171375
GO:0006383 transcription from RNA polymerase III promoter IEA --
GO:0008283 cell proliferation IEP 24107381
GO:0032481 positive regulation of type I interferon production TAS --
genes like me logo Genes that share ontologies with POLR3G: view

No data available for SIGNOR curated interactions for POLR3G Gene

Drugs & Compounds for POLR3G Gene

(5) Drugs for POLR3G Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nevirapine Approved Pharma 223
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0

(1) Additional Compounds for POLR3G Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with POLR3G: view

Transcripts for POLR3G Gene

Unigene Clusters for POLR3G Gene

Polymerase (RNA) III (DNA directed) polypeptide G (32kD):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR3G Gene

No ASD Table

Relevant External Links for POLR3G Gene

GeneLoc Exon Structure for
POLR3G
ECgene alternative splicing isoforms for
POLR3G

Expression for POLR3G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR3G Gene

Protein differential expression in normal tissues from HIPED for POLR3G Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POLR3G Gene



Protein tissue co-expression partners for POLR3G Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLR3G Gene:

POLR3G

SOURCE GeneReport for Unigene cluster for POLR3G Gene:

Hs.282387

Evidence on tissue expression from TISSUES for POLR3G Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with POLR3G: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR3G Gene

Orthologs for POLR3G Gene

This gene was present in the common ancestor of chordates.

Orthologs for POLR3G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR3G 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia POLR3G 34 35
  • 92.53 (n)
cow
(Bos Taurus)
Mammalia POLR3G 34 35
  • 90.43 (n)
rat
(Rattus norvegicus)
Mammalia Polr3g 34
  • 83.78 (n)
mouse
(Mus musculus)
Mammalia Polr3g 34 16 35
  • 83.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia POLR3G 35
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLR3G 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves POLR3G 34 35
  • 75.27 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia polr3g 34
  • 66.51 (n)
zebrafish
(Danio rerio)
Actinopterygii polr3g 34 35
  • 63.96 (n)
Species where no ortholog for POLR3G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POLR3G Gene

ENSEMBL:
Gene Tree for POLR3G (if available)
TreeFam:
Gene Tree for POLR3G (if available)

Paralogs for POLR3G Gene

Paralogs for POLR3G Gene

(1) SIMAP similar genes for POLR3G Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for POLR3G Gene

genes like me logo Genes that share paralogs with POLR3G: view

Variants for POLR3G Gene

Sequence variations from dbSNP and Humsavar for POLR3G Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000066480 -- 90,505,064(+) CTGTT(A/G)TCTTT intron-variant
rs1000241739 -- 90,497,304(+) TATCA(A/G)CTACA intron-variant
rs1000302982 -- 90,500,126(+) CAACA(A/C)TGAAA intron-variant
rs1000315216 -- 90,484,214(+) CACTC(A/G)CAGTT intron-variant, upstream-variant-2KB
rs1000402294 -- 90,479,294(+) TGGTG(A/G)AACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR3G Gene

Variant ID Type Subtype PubMed ID
esv2666589 CNV deletion 23128226
esv3441535 CNV insertion 20981092
esv3605765 CNV loss 21293372
nsv518131 CNV loss 19592680
nsv823125 CNV loss 20364138
nsv968218 CNV duplication 23825009

Variation tolerance for POLR3G Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR3G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR3G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR3G Gene

Disorders for POLR3G Gene

MalaCards: The human disease database

(1) MalaCards diseases for POLR3G Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
leukemia, acute myelomonocytic, somatic, somatic
  • leukemia, juvenile myelomonocytic, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POLR3G

Genetic Association Database (GAD)
POLR3G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR3G
genes like me logo Genes that share disorders with POLR3G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR3G Gene

Publications for POLR3G Gene

  1. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PMID: 12391170) Hu P. … Hernandez N. (Mol. Cell. Biol. 2002) 2 3 4 64
  2. Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation. (PMID: 9171375) Wang Z. … Roeder R.G. (Genes Dev. 1997) 2 3 4 64
  3. Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash. (PMID: 21810746) Chantarangsu S. … Nakamura Y. (Clin. Infect. Dis. 2011) 3 46 64
  4. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. (PMID: 19609254) Ablasser A. … Hornung V. (Nat. Immunol. 2009) 3 4 64
  5. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. (PMID: 19631370) Chiu Y.-H. … Chen Z.J. (Cell 2009) 3 4 64

Products for POLR3G Gene

Sources for POLR3G Gene

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