Free for academic non-profit institutions. Other users need a Commercial license

Aliases for POLR3G Gene

Aliases for POLR3G Gene

  • Polymerase (RNA) III Subunit G 2 3
  • Polymerase (RNA) III (DNA Directed) Polypeptide G (32kD) 2 3 5
  • DNA-Directed RNA Polymerase III Subunit G 3 4
  • RNA Polymerase III 32 KDa Subunit 3 4
  • RNA Polymerase III Subunit C7 3 4
  • RPC32 3 4
  • DNA-Directed RNA Polymerase III 32 KDa Polypeptide 3
  • RPC7 3

External Ids for POLR3G Gene

Previous GeneCards Identifiers for POLR3G Gene

  • GC05P089854
  • GC05P089807
  • GC05P084981

Summaries for POLR3G Gene

GeneCards Summary for POLR3G Gene

POLR3G (Polymerase (RNA) III Subunit G) is a Protein Coding gene. Diseases associated with POLR3G include Leukemia, Acute Myelomonocytic, Somatic, Somatic. Among its related pathways are RNA Polymerase III Transcription Initiation and Gene Expression. GO annotations related to this gene include DNA-directed RNA polymerase activity and RNA polymerase III activity. An important paralog of this gene is ENSG00000280778.

UniProtKB/Swiss-Prot for POLR3G Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR3G Gene

Genomics for POLR3G Gene

Regulatory Elements for POLR3G Gene

Enhancers for POLR3G Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POLR3G on UCSC Golden Path with GeneCards custom track

Genomic Location for POLR3G Gene

Chromosome:
5
Start:
90,471,748 bp from pter
End:
90,514,677 bp from pter
Size:
42,930 bases
Orientation:
Plus strand

Genomic View for POLR3G Gene

Genes around POLR3G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR3G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR3G Gene

Proteins for POLR3G Gene

  • Protein details for POLR3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15318-RPC7_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC7
    Protein Accession:
    O15318
    Secondary Accessions:
    • A8MTH0

    Protein attributes for POLR3G Gene

    Size:
    223 amino acids
    Molecular mass:
    25914 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex.
    SequenceCaution:
    • Sequence=AAB63676.1; Type=Frameshift; Positions=214; Evidence={ECO:0000305};

neXtProt entry for POLR3G Gene

Proteomics data for POLR3G Gene at MOPED

Post-translational modifications for POLR3G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for POLR3G Gene

Domains & Families for POLR3G Gene

Gene Families for POLR3G Gene

Protein Domains for POLR3G Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for POLR3G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15318

UniProtKB/Swiss-Prot:

RPC7_HUMAN :
  • Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
Family:
  • Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR3G: view

Function for POLR3G Gene

Molecular function for POLR3G Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
genes like me logo Genes that share phenotypes with POLR3G: view

Animal Models for POLR3G Gene

MGI Knock Outs for POLR3G:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POLR3G Gene

Localization for POLR3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR3G Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR3G Gene COMPARTMENTS Subcellular localization image for POLR3G gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for POLR3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR3G: view

Pathways & Interactions for POLR3G Gene

genes like me logo Genes that share pathways with POLR3G: view

Gene Ontology (GO) - Biological Process for POLR3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006359 regulation of transcription from RNA polymerase III promoter IEA --
GO:0006383 transcription from RNA polymerase III promoter TAS --
GO:0006384 transcription initiation from RNA polymerase III promoter IBA --
GO:0032481 positive regulation of type I interferon production TAS --
GO:0032728 positive regulation of interferon-beta production IMP 19609254
genes like me logo Genes that share ontologies with POLR3G: view

No data available for SIGNOR curated interactions for POLR3G Gene

Drugs & Compounds for POLR3G Gene

(6) Drugs for POLR3G Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nevirapine Approved Pharma 223
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with POLR3G: view

Transcripts for POLR3G Gene

Unigene Clusters for POLR3G Gene

Polymerase (RNA) III (DNA directed) polypeptide G (32kD):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLR3G Gene

No ASD Table

Relevant External Links for POLR3G Gene

GeneLoc Exon Structure for
POLR3G
ECgene alternative splicing isoforms for
POLR3G

Expression for POLR3G Gene

mRNA expression in normal human tissues for POLR3G Gene

Protein differential expression in normal tissues from HIPED for POLR3G Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLR3G Gene



SOURCE GeneReport for Unigene cluster for POLR3G Gene Hs.282387

genes like me logo Genes that share expression patterns with POLR3G: view

Protein tissue co-expression partners for POLR3G Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLR3G Gene

Orthologs for POLR3G Gene

This gene was present in the common ancestor of chordates.

Orthologs for POLR3G Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POLR3G 35
  • 90.43 (n)
  • 90.58 (a)
POLR3G 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR3G 35
  • 92.53 (n)
  • 92.83 (a)
POLR3G 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr3g 35
  • 83.63 (n)
  • 83.33 (a)
Polr3g 16
Polr3g 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLR3G 35
  • 99.55 (n)
  • 99.55 (a)
POLR3G 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polr3g 35
  • 83.78 (n)
  • 83.78 (a)
oppossum
(Monodelphis domestica)
Mammalia POLR3G 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLR3G 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves POLR3G 35
  • 75.27 (n)
  • 69.95 (a)
POLR3G 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr3g 35
  • 66.51 (n)
  • 58.65 (a)
zebrafish
(Danio rerio)
Actinopterygii polr3g 35
  • 63.96 (n)
  • 55.02 (a)
polr3g 36
  • 50 (a)
OneToOne
Species with no ortholog for POLR3G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POLR3G Gene

ENSEMBL:
Gene Tree for POLR3G (if available)
TreeFam:
Gene Tree for POLR3G (if available)

Paralogs for POLR3G Gene

Paralogs for POLR3G Gene

(1) SIMAP similar genes for POLR3G Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for POLR3G Gene

genes like me logo Genes that share paralogs with POLR3G: view

Variants for POLR3G Gene

Sequence variations from dbSNP and Humsavar for POLR3G Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs790080 -- 90,479,200(-) gccac(C/G/T)gcgcc intron-variant
rs790082 -- 90,510,241(-) gccac(C/T)acgcc intron-variant
rs809840 -- 90,479,209(-) caggc(A/G)tgagc intron-variant
rs812594 -- 90,510,930(-) GACTA(C/T)TCTCA intron-variant
rs27198 -- 90,507,371(-) TTTCC(A/G)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR3G Gene

Variant ID Type Subtype PubMed ID
nsv518131 CNV Loss 19592680
nsv882364 CNV Gain 21882294
nsv882365 CNV Gain 21882294
esv2666589 CNV Deletion 23128226
nsv823125 CNV Loss 20364138

Variation tolerance for POLR3G Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for POLR3G Gene

Disorders for POLR3G Gene

MalaCards: The human disease database

(1) MalaCards diseases for POLR3G Gene - From: DISEASES

Disorder Aliases PubMed IDs
leukemia, acute myelomonocytic, somatic, somatic
  • leukemia, juvenile myelomonocytic, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POLR3G

Genetic Association Database (GAD)
POLR3G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR3G
genes like me logo Genes that share disorders with POLR3G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR3G Gene

Publications for POLR3G Gene

  1. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PMID: 12391170) Hu P. … Hernandez N. (Mol. Cell. Biol. 2002) 2 3 4 67
  2. Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation. (PMID: 9171375) Wang Z. … Roeder R.G. (Genes Dev. 1997) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for POLR3G Gene

Sources for POLR3G Gene

Content