Aliases for POLR3D Gene
External Ids for POLR3D Gene
Previous HGNC Symbols for POLR3D Gene
Previous GeneCards Identifiers for POLR3D Gene
This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008]
GeneCards Summary for POLR3D Gene
POLR3D (Polymerase (RNA) III Subunit D) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include chromatin binding and RNA polymerase III activity.
UniProtKB/Swiss-Prot for POLR3D Gene
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).