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Aliases for POLR3D Gene

Aliases for POLR3D Gene

  • RNA Polymerase III Subunit D 2 3 5
  • Polymerase (RNA) III (DNA Directed) Polypeptide D, 44kDa 2 3
  • BN51 (BHK21) Temperature Sensitivity Complementing 2 3
  • DNA-Directed RNA Polymerase III Subunit D 3 4
  • RNA Polymerase III 47 KDa Subunit 3 4
  • RNA Polymerase III Subunit C4 3 4
  • RPC53 Homolog 3 4
  • BN51T 3 4
  • Temperature Sensitive Complementation, Cell Cycle Specific, TsBN51 3
  • DNA-Directed RNA Polymerase III 47 KDa Polypeptide 3
  • DNA-Directed RNA Polymerase III Subunit RPC4 3
  • Polymerase (RNA) III Subunit D 3
  • Protein BN51 4
  • TSBN51 3
  • RPC53 3
  • RPC4 3
  • BN51 4

External Ids for POLR3D Gene

Previous HGNC Symbols for POLR3D Gene

  • BN51T

Previous GeneCards Identifiers for POLR3D Gene

  • GC08P022455
  • GC08P021923
  • GC08P022124
  • GC08P022158
  • GC08P022102
  • GC08P020644
  • GC08P022248
  • GC08P022249
  • GC08P022250
  • GC08P022251
  • GC08P022252
  • GC08P022254

Summaries for POLR3D Gene

Entrez Gene Summary for POLR3D Gene

  • This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR3D Gene

POLR3D (RNA Polymerase III Subunit D) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and RNA Polymerase III Transcription Initiation. GO annotations related to this gene include chromatin binding and RNA polymerase III activity.

UniProtKB/Swiss-Prot for POLR3D Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Gene Wiki entry for POLR3D Gene

Additional gene information for POLR3D Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR3D Gene

Genomics for POLR3D Gene

Regulatory Elements for POLR3D Gene

Enhancers for POLR3D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H022450 0.9 dbSUPER 47.9 +205.4 205375 0 ZNF493 ZFP64 ZEB1 ZNF354C ZNF202 ZNF654 ZNF680 ZC3H11A OVOL3 REST FAM160B2 ENSG00000253200 SORBS3 BMP1 POLR3D CCAR2 C8orf58 LOC107986927 LOXL2 LOC100507156
GH08H023159 1.7 FANTOM5 ENCODE dbSUPER 24.4 +917.3 917285 5 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ENSG00000253200 ENTPD4 C8orf58 POLR3D CCAR2 BIN3 CHMP7 LOC389641 TNFRSF10A ENSG00000250714
GH08H022439 2 FANTOM5 Ensembl ENCODE dbSUPER 14.8 +199.6 199562 10 HDGF PKNOX1 MLX ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 CCAR2 ENSG00000253200 C8orf58 ENSG00000251034 XPO7 PPP3CC SORBS3 FAM160B2 POLR3D BIN3
GH08H022603 1.2 ENCODE 18.6 +359.9 359905 3 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 C8orf58 ENSG00000253200 CCAR2 SORBS3 FAM160B2 LOC107986927 BMP1 POLR3D XPO7 LOC100507156
GH08H022755 1.5 Ensembl ENCODE dbSUPER 13.7 +511.6 511634 2 HDGF FOXA2 MLX SIN3A ARID4B DMAP1 TCF12 SLC30A9 GLIS2 ZNF143 PPP3CC POLR3D BIN3 LOC101929237 RNU6-336P GC08M022705 GC08M022746
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLR3D on UCSC Golden Path with GeneCards custom track

Promoters for POLR3D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000222031 96 2001 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766

Genomic Location for POLR3D Gene

Chromosome:
8
Start:
22,245,104 bp from pter
End:
22,254,600 bp from pter
Size:
9,497 bases
Orientation:
Plus strand

Genomic View for POLR3D Gene

Genes around POLR3D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR3D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR3D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR3D Gene

Proteins for POLR3D Gene

  • Protein details for POLR3D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05423-RPC4_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC4
    Protein Accession:
    P05423
    Secondary Accessions:
    • Q6FI28
    • Q9BPV7
    • Q9BPZ1
    • Q9BXB3

    Protein attributes for POLR3D Gene

    Size:
    398 amino acids
    Molecular mass:
    44396 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). Interacts with POLR3E/RPC5.
    SequenceCaution:
    • Sequence=BC000516; Type=Frameshift; Positions=175; Evidence={ECO:0000305}; Sequence=BC003039; Type=Frameshift; Positions=175; Evidence={ECO:0000305};

neXtProt entry for POLR3D Gene

Post-translational modifications for POLR3D Gene

  • Ubiquitination at posLast=328328 and posLast=396396
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR3D Gene

No data available for DME Specific Peptides for POLR3D Gene

Domains & Families for POLR3D Gene

Gene Families for POLR3D Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for POLR3D Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for POLR3D Gene

Graphical View of Domain Structure for InterPro Entry

P05423

UniProtKB/Swiss-Prot:

RPC4_HUMAN :
  • Belongs to the eukaryotic RPC4/POLR3D RNA polymerase subunit family.
Family:
  • Belongs to the eukaryotic RPC4/POLR3D RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR3D: view

Function for POLR3D Gene

Molecular function for POLR3D Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Phenotypes From GWAS Catalog for POLR3D Gene

Gene Ontology (GO) - Molecular Function for POLR3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001056 contributes_to RNA polymerase III activity IBA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003899 DNA-directed 5-3 RNA polymerase activity IEA --
genes like me logo Genes that share ontologies with POLR3D: view

Phenotypes for POLR3D Gene

genes like me logo Genes that share phenotypes with POLR3D: view

Animal Model Products

CRISPR Products

miRNA for POLR3D Gene

miRTarBase miRNAs that target POLR3D

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for POLR3D
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR3D Gene

Localization for POLR3D Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR3D Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR3D gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for POLR3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 colocalizes_with nuclear chromatin IDA 24107381
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005666 DNA-directed RNA polymerase III complex IEA,IDA 24107381
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR3D: view

Pathways & Interactions for POLR3D Gene

genes like me logo Genes that share pathways with POLR3D: view

Gene Ontology (GO) - Biological Process for POLR3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006383 transcription from RNA polymerase III promoter IEA --
GO:0032481 positive regulation of type I interferon production TAS --
GO:0032728 positive regulation of interferon-beta production IDA 19631370
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with POLR3D: view

No data available for SIGNOR curated interactions for POLR3D Gene

Drugs & Compounds for POLR3D Gene

(5) Drugs for POLR3D Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for POLR3D Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with POLR3D: view

Transcripts for POLR3D Gene

Unigene Clusters for POLR3D Gene

Polymerase (RNA) III (DNA directed) polypeptide D, 44kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for POLR3D
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for POLR3D Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP1: - -
SP2: -
SP3:

Relevant External Links for POLR3D Gene

GeneLoc Exon Structure for
POLR3D
ECgene alternative splicing isoforms for
POLR3D

Expression for POLR3D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR3D Gene

Protein differential expression in normal tissues from HIPED for POLR3D Gene

This gene is overexpressed in Adipocyte (12.3), Retina (8.8), Testis (7.3), and Gallbladder (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POLR3D Gene



Protein tissue co-expression partners for POLR3D Gene

NURSA nuclear receptor signaling pathways regulating expression of POLR3D Gene:

POLR3D

SOURCE GeneReport for Unigene cluster for POLR3D Gene:

Hs.148342

Evidence on tissue expression from TISSUES for POLR3D Gene

  • Lung(4.1)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with POLR3D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR3D Gene

Orthologs for POLR3D Gene

This gene was present in the common ancestor of animals.

Orthologs for POLR3D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR3D 33 34
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia POLR3D 33 34
  • 90.7 (n)
cow
(Bos Taurus)
Mammalia POLR3D 33 34
  • 89.41 (n)
rat
(Rattus norvegicus)
Mammalia Polr3d 33
  • 86.93 (n)
mouse
(Mus musculus)
Mammalia Polr3d 33 16 34
  • 86.85 (n)
oppossum
(Monodelphis domestica)
Mammalia POLR3D 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLR3D 34
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLR3D 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr3d 33
  • 64.27 (n)
Str.12617 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.31157 33
zebrafish
(Danio rerio)
Actinopterygii polr3d 33 34
  • 62.77 (n)
zgc56407 33
fruit fly
(Drosophila melanogaster)
Insecta CG5147 34
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
OneToOne
Species where no ortholog for POLR3D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POLR3D Gene

ENSEMBL:
Gene Tree for POLR3D (if available)
TreeFam:
Gene Tree for POLR3D (if available)

Paralogs for POLR3D Gene

Pseudogenes.org Pseudogenes for POLR3D Gene

genes like me logo Genes that share paralogs with POLR3D: view

No data available for Paralogs for POLR3D Gene

Variants for POLR3D Gene

Sequence variations from dbSNP and Humsavar for POLR3D Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1001190133 -- 22,244,676(+) GCCCG(G/T)AGGTA downstream-variant-500B, upstream-variant-2KB
rs1001472735 -- 22,245,249(+) GCGGG(A/G/T)TTCCT intron-variant, upstream-variant-2KB
rs1001620135 -- 22,244,493(+) ATTCC(A/C)ATTCC downstream-variant-500B, upstream-variant-2KB
rs1002475428 -- 22,246,166(+) GTTGT(A/C)CCCCA intron-variant, upstream-variant-2KB
rs1002890766 -- 22,245,167(+) CTGGC(A/G)GCTGG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for POLR3D Gene

Variant ID Type Subtype PubMed ID
dgv12054n54 CNV loss 21841781
esv2759604 CNV loss 17122850
nsv470205 CNV loss 18288195
nsv6115 CNV insertion 18451855
nsv831264 CNV gain+loss 17160897
nsv831265 CNV loss 17160897

Variation tolerance for POLR3D Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR3D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR3D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR3D Gene

Disorders for POLR3D Gene

Relevant External Links for POLR3D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR3D

No disorders were found for POLR3D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR3D Gene

Publications for POLR3D Gene

  1. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PMID: 12391170) Hu P … Hernandez N (Molecular and cellular biology 2002) 2 3 4 60
  2. Reconstitution of transcription from the human U6 small nuclear RNA promoter with eight recombinant polypeptides and a partially purified RNA polymerase III complex. (PMID: 11279001) Chong SS … Hernandez N (The Journal of biological chemistry 2001) 2 3 4 60
  3. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. (PMID: 19631370) Chiu YH … Chen ZJ (Cell 2009) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The BN51 protein is a polymerase (Pol)-specific subunit of RNA Pol III which reveals a link between Pol III transcription and pre-rRNA processing. (PMID: 7799973) Jackson AJ … Pugh BF (Molecular and cellular biology 1995) 3 22 60

Products for POLR3D Gene

Sources for POLR3D Gene

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