Free for academic non-profit institutions. Other users need a Commercial license

Aliases for POLR3C Gene

Aliases for POLR3C Gene

  • RNA Polymerase III Subunit C 2 3 5
  • Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) 2 3
  • DNA-Directed RNA Polymerase III Subunit C 3 4
  • RNA Polymerase III 62 KDa Subunit 3 4
  • RNA Polymerase III Subunit C3 3 4
  • RPC62 3 4
  • DNA-Directed RNA Polymerase III Subunit RPC3 3
  • DNA-Directed III 62 KDa Polypeptide 3
  • Polymerase (RNA) III Subunit C 3
  • RPC3 3

External Ids for POLR3C Gene

Previous GeneCards Identifiers for POLR3C Gene

  • GC01M143342
  • GC01M143081
  • GC01M144303
  • GC01M145592
  • GC01M119556

Summaries for POLR3C Gene

GeneCards Summary for POLR3C Gene

POLR3C (RNA Polymerase III Subunit C) is a Protein Coding gene. Among its related pathways are Immune System and Cytosolic sensors of pathogen-associated DNA. GO annotations related to this gene include DNA-directed RNA polymerase activity and RNA polymerase III activity.

UniProtKB/Swiss-Prot for POLR3C Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Gene Wiki entry for POLR3C Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR3C Gene

Genomics for POLR3C Gene

Regulatory Elements for POLR3C Gene

Enhancers for POLR3C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F146034 0.6 Ensembl ENCODE 77.7 +213.5 213509 5.6 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 TBX21 ZFP41 POLR3C NOTCH2NL ANKRD35 NUDT17 TXNIP GNRHR2 LINC01719 NBPF12 HFE2 TRG-TCC2-1
GH01F144997 1.1 Ensembl ENCODE 65.6 -824.6 -824566 4.2 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF302 ZNF548 FOS ZNF263 POLR3C PFN1P6 NBPF25P ENSG00000224363 NUDT17 ENSG00000271644 FAM72D
GH01F146050 0.8 ENCODE 52.4 +227.6 227640 2.7 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 TBX21 MEF2D POLR3C NOTCH2NL ANKRD35 LINC01719 GC01M146050 RNVU1-6
GH01F145713 1 Ensembl ENCODE 48.2 -108.4 -108372 3.8 ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2 ZNF143 POLR3C PDZK1 NUDT17 CD160
GH01F145976 1 FANTOM5 ENCODE 37.1 +157.9 157917 10.0 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 YY1 POLR3C ANKRD35 NOTCH2NL HFE2 RBM8A LIX1L-AS1 PEX11B GNRHR2 LIX1L TXNIP
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around POLR3C on UCSC Golden Path with GeneCards custom track

Promoters for POLR3C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000079664 -169 3401 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A YBX1

Genomic Location for POLR3C Gene

Chromosome:
1
Start:
145,824,069 bp from pter
End:
145,844,402 bp from pter
Size:
20,334 bases
Orientation:
Plus strand

Genomic View for POLR3C Gene

Genes around POLR3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR3C Gene

Proteins for POLR3C Gene

  • Protein details for POLR3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUI4-RPC3_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC3
    Protein Accession:
    Q9BUI4
    Secondary Accessions:
    • O15317
    • Q9Y3R6

    Protein attributes for POLR3C Gene

    Size:
    534 amino acids
    Molecular mass:
    60612 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex. Interacts with GTF3C4 (By similarity).
    Miscellaneous:
    • Antibodies against POLR3C have been found in the sera of patients with systemic sclerosis (SSc).

    Three dimensional structures from OCA and Proteopedia for POLR3C Gene

neXtProt entry for POLR3C Gene

Post-translational modifications for POLR3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POLR3C Gene

No data available for DME Specific Peptides for POLR3C Gene

Domains & Families for POLR3C Gene

Gene Families for POLR3C Gene

Protein Domains for POLR3C Gene

Suggested Antigen Peptide Sequences for POLR3C Gene

Graphical View of Domain Structure for InterPro Entry

Q9BUI4

UniProtKB/Swiss-Prot:

RPC3_HUMAN :
  • Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
Family:
  • Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR3C: view

Function for POLR3C Gene

Molecular function for POLR3C Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Gene Ontology (GO) - Molecular Function for POLR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001056 contributes_to RNA polymerase III activity IBA --
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed RNA polymerase activity TAS 9171375
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with POLR3C: view
genes like me logo Genes that share phenotypes with POLR3C: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POLR3C Gene

Localization for POLR3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR3C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR3C Gene COMPARTMENTS Subcellular localization image for POLR3C gene
Compartment Confidence
nucleus 3
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for POLR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA --
GO:0005654 nucleoplasm TAS --
GO:0005666 DNA-directed RNA polymerase III complex IDA,TAS 24107381
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR3C: view

Pathways & Interactions for POLR3C Gene

genes like me logo Genes that share pathways with POLR3C: view

Gene Ontology (GO) - Biological Process for POLR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006359 regulation of transcription from RNA polymerase III promoter TAS 9171375
GO:0006383 transcription from RNA polymerase III promoter IEA --
GO:0032481 positive regulation of type I interferon production TAS --
genes like me logo Genes that share ontologies with POLR3C: view

No data available for SIGNOR curated interactions for POLR3C Gene

Drugs & Compounds for POLR3C Gene

(4) Drugs for POLR3C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0

(1) Additional Compounds for POLR3C Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with POLR3C: view

Transcripts for POLR3C Gene

Unigene Clusters for POLR3C Gene

Polymerase (RNA) III (DNA directed) polypeptide C (62kD):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR3C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ·
SP1: - - - - -
SP2: - - -
SP3: - - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: -
SP7:
SP8: - - -
SP9:

ExUns: 18c ^ 19
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for POLR3C Gene

GeneLoc Exon Structure for
POLR3C
ECgene alternative splicing isoforms for
POLR3C

Expression for POLR3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POLR3C Gene

Protein differential expression in normal tissues from HIPED for POLR3C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.2), Testis (11.0), and CD8 Tcells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POLR3C Gene



Protein tissue co-expression partners for POLR3C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLR3C Gene:

POLR3C

SOURCE GeneReport for Unigene cluster for POLR3C Gene:

Hs.591457
genes like me logo Genes that share expression patterns with POLR3C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLR3C Gene

Orthologs for POLR3C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR3C 34 35
  • 99.88 (n)
dog
(Canis familiaris)
Mammalia POLR3C 34 35
  • 92.63 (n)
cow
(Bos Taurus)
Mammalia POLR3C 34 35
  • 92.12 (n)
rat
(Rattus norvegicus)
Mammalia Polr3c 34
  • 87.93 (n)
mouse
(Mus musculus)
Mammalia Polr3c 34 16 35
  • 87.18 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 87 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia POLR3C 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr3c 34
  • 72.34 (n)
Str.5213 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.26628 34
zebrafish
(Danio rerio)
Actinopterygii polr3c 34 35
  • 64.71 (n)
zgc56348 34
fruit fly
(Drosophila melanogaster)
Insecta CG12267 34 35
  • 46.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002394 34
  • 44.97 (n)
worm
(Caenorhabditis elegans)
Secernentea C48E7.2 34 35
  • 42.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPC82 35 37
  • 16 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G49000 34
  • 41.82 (n)
rice
(Oryza sativa)
Liliopsida Os01g0679000 34
  • 38.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11029 34
Species where no ortholog for POLR3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR3C Gene

ENSEMBL:
Gene Tree for POLR3C (if available)
TreeFam:
Gene Tree for POLR3C (if available)

Paralogs for POLR3C Gene

No data available for Paralogs for POLR3C Gene

Variants for POLR3C Gene

Sequence variations from dbSNP and Humsavar for POLR3C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1044697 -- 145,833,309(-) ATTCC(A/G)CCAAC nc-transcript-variant, reference, missense
rs10564953 -- 145,843,377(-) TATAA(-/AAC)AACAT upstream-variant-2KB, cds-indel
rs10590228 -- 145,843,215(-) TTCTA(-/CA)TACAC downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs10752826 -- 145,832,321(-) CCTTA(C/G)TGTCA intron-variant
rs111305179 -- 145,836,630(-) AGAAA(C/T)AAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR3C Gene

Variant ID Type Subtype PubMed ID
dgv331n100 CNV gain 25217958
dgv33n27 CNV loss 19166990
dgv531n54 CNV loss 21841781
esv3572008 CNV gain 25503493
esv3587420 CNV gain 21293372
esv3894089 CNV loss 25118596
nsv1005055 CNV loss 25217958
nsv1015025 CNV gain 25217958
nsv831381 CNV gain 17160897

Variation tolerance for POLR3C Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR3C Gene

Human Gene Mutation Database (HGMD)
POLR3C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR3C Gene

Disorders for POLR3C Gene

Relevant External Links for POLR3C

Human Genome Epidemiology (HuGE) Navigator
POLR3C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR3C

No disorders were found for POLR3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR3C Gene

Publications for POLR3C Gene

  1. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PMID: 12391170) Hu P. … Hernandez N. (Mol. Cell. Biol. 2002) 2 3 4 64
  2. Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation. (PMID: 9171375) Wang Z. … Roeder R.G. (Genes Dev. 1997) 2 3 4 64
  3. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. (PMID: 19609254) Ablasser A. … Hornung V. (Nat. Immunol. 2009) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay. (PMID: 12384934) Kuwana M. … Kawakami Y. (Arthritis Rheum. 2002) 3 4 64

Products for POLR3C Gene

Sources for POLR3C Gene

Content
Loading form....