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Aliases for POLR3C Gene

Aliases for POLR3C Gene

  • Polymerase (RNA) III Subunit C 2 3
  • Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) 2 3 5
  • DNA-Directed RNA Polymerase III Subunit C 3 4
  • RNA Polymerase III 62 KDa Subunit 3 4
  • RNA Polymerase III Subunit C3 3 4
  • RPC62 3 4
  • DNA-Directed III 62 KDa Polypeptide 3
  • RPC3 3

External Ids for POLR3C Gene

Previous GeneCards Identifiers for POLR3C Gene

  • GC01M143342
  • GC01M143081
  • GC01M144303
  • GC01M145592
  • GC01M119556

Summaries for POLR3C Gene

GeneCards Summary for POLR3C Gene

POLR3C (Polymerase (RNA) III Subunit C) is a Protein Coding gene. Among its related pathways are RNA Polymerase III Transcription Initiation and Gene Expression. GO annotations related to this gene include DNA-directed RNA polymerase activity and RNA polymerase III activity.

UniProtKB/Swiss-Prot for POLR3C Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Gene Wiki entry for POLR3C Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR3C Gene

Genomics for POLR3C Gene

Regulatory Elements for POLR3C Gene

Enhancers for POLR3C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POLR3C on UCSC Golden Path with GeneCards custom track

Promoters for POLR3C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POLR3C on UCSC Golden Path with GeneCards custom track

Genomic Location for POLR3C Gene

Chromosome:
1
Start:
145,824,069 bp from pter
End:
145,844,402 bp from pter
Size:
20,334 bases
Orientation:
Plus strand

Genomic View for POLR3C Gene

Genes around POLR3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR3C Gene

Proteins for POLR3C Gene

  • Protein details for POLR3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUI4-RPC3_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC3
    Protein Accession:
    Q9BUI4
    Secondary Accessions:
    • O15317
    • Q9Y3R6

    Protein attributes for POLR3C Gene

    Size:
    534 amino acids
    Molecular mass:
    60612 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex. Interacts with GTF3C4 (By similarity).
    Miscellaneous:
    • Antibodies against POLR3C have been found in the sera of patients with systemic sclerosis (SSc).

    Three dimensional structures from OCA and Proteopedia for POLR3C Gene

neXtProt entry for POLR3C Gene

Proteomics data for POLR3C Gene at MOPED

Post-translational modifications for POLR3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POLR3C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POLR3C Gene

Domains & Families for POLR3C Gene

Gene Families for POLR3C Gene

Protein Domains for POLR3C Gene

Suggested Antigen Peptide Sequences for POLR3C Gene

Graphical View of Domain Structure for InterPro Entry

Q9BUI4

UniProtKB/Swiss-Prot:

RPC3_HUMAN :
  • Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
Family:
  • Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR3C: view

Function for POLR3C Gene

Molecular function for POLR3C Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Gene Ontology (GO) - Molecular Function for POLR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003899 DNA-directed RNA polymerase activity IEA,TAS 9171375
genes like me logo Genes that share ontologies with POLR3C: view
genes like me logo Genes that share phenotypes with POLR3C: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POLR3C Gene

Localization for POLR3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR3C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR3C Gene COMPARTMENTS Subcellular localization image for POLR3C gene
Compartment Confidence
nucleus 3
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for POLR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR3C: view

Pathways & Interactions for POLR3C Gene

genes like me logo Genes that share pathways with POLR3C: view

Gene Ontology (GO) - Biological Process for POLR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006359 regulation of transcription from RNA polymerase III promoter TAS 9171375
GO:0006383 transcription from RNA polymerase III promoter IBA,TAS --
GO:0032481 positive regulation of type I interferon production TAS --
GO:0032728 positive regulation of interferon-beta production IMP 19609254
GO:0045087 innate immune response IEA,TAS --
genes like me logo Genes that share ontologies with POLR3C: view

No data available for SIGNOR curated interactions for POLR3C Gene

Drugs & Compounds for POLR3C Gene

(5) Drugs for POLR3C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with POLR3C: view

Transcripts for POLR3C Gene

Unigene Clusters for POLR3C Gene

Polymerase (RNA) III (DNA directed) polypeptide C (62kD):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLR3C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ·
SP1: - - - - -
SP2: - - -
SP3: - - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: -
SP7:
SP8: - - -
SP9:

ExUns: 18c ^ 19
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for POLR3C Gene

GeneLoc Exon Structure for
POLR3C
ECgene alternative splicing isoforms for
POLR3C

Expression for POLR3C Gene

mRNA expression in normal human tissues for POLR3C Gene

Protein differential expression in normal tissues from HIPED for POLR3C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.2), Testis (11.0), and CD8 Tcells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLR3C Gene



SOURCE GeneReport for Unigene cluster for POLR3C Gene Hs.591457

genes like me logo Genes that share expression patterns with POLR3C: view

Protein tissue co-expression partners for POLR3C Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLR3C Gene

Orthologs for POLR3C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR3C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POLR3C 35
  • 92.12 (n)
  • 95.87 (a)
POLR3C 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR3C 35
  • 92.63 (n)
  • 96.25 (a)
POLR3C 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr3c 35
  • 87.18 (n)
  • 94 (a)
Polr3c 16
Polr3c 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLR3C 35
  • 99.88 (n)
  • 100 (a)
POLR3C 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polr3c 35
  • 87.93 (n)
  • 94 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia POLR3C 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr3c 35
  • 72.34 (n)
  • 76.9 (a)
Str.5213 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.26628 35
zebrafish
(Danio rerio)
Actinopterygii polr3c 35
  • 64.71 (n)
  • 66.22 (a)
zgc56348 35
polr3c 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002394 35
  • 44.97 (n)
  • 33.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12267 35
  • 46.94 (n)
  • 35.92 (a)
CG12267 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C48E7.2 35
  • 42.72 (n)
  • 27.55 (a)
C48E7.2 36
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPC82 36
  • 16 (a)
OneToOne
RPC82 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G49000 35
  • 41.82 (n)
  • 26.4 (a)
rice
(Oryza sativa)
Liliopsida Os01g0679000 35
  • 38.36 (n)
  • 23.62 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11029 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for POLR3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR3C Gene

ENSEMBL:
Gene Tree for POLR3C (if available)
TreeFam:
Gene Tree for POLR3C (if available)

Paralogs for POLR3C Gene

No data available for Paralogs for POLR3C Gene

Variants for POLR3C Gene

Sequence variations from dbSNP and Humsavar for POLR3C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1044697 - 145,833,309(-) ATTCC(A/G)CCAAC nc-transcript-variant, reference, missense
rs913513 -- 145,839,687(+) TATCA(C/T)GCCAC intron-variant
rs1536746 -- 145,834,166(+) GTAAC(A/G)CAGTA intron-variant
rs1887806 -- 145,840,311(+) GAGGC(A/G)GGTGG intron-variant
rs2018027 -- 145,839,290(+) TACGA(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR3C Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
dgv15n16 CNV Deletion 17901297
dgv46e201 CNV Deletion 23290073
esv2422428 CNV Duplication 17116639
dgv347n71 CNV Gain 21882294
nsv831370 CNV Gain 17160897
nsv831381 CNV Gain 17160897
nsv872232 CNV Gain 21882294
esv529 CNV CNV 17122850
dgv33n27 CNV Loss 19166990

Variation tolerance for POLR3C Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR3C Gene

Human Gene Mutation Database (HGMD)
POLR3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR3C Gene

Disorders for POLR3C Gene

Relevant External Links for POLR3C

Human Genome Epidemiology (HuGE) Navigator
POLR3C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR3C

No disorders were found for POLR3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR3C Gene

Publications for POLR3C Gene

  1. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PMID: 12391170) Hu P. … Hernandez N. (Mol. Cell. Biol. 2002) 2 3 4 67
  2. Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation. (PMID: 9171375) Wang Z. … Roeder R.G. (Genes Dev. 1997) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for POLR3C Gene

Sources for POLR3C Gene

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