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Aliases for POLR3C Gene

Aliases for POLR3C Gene

  • RNA Polymerase III Subunit C 2 3 5
  • Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) 2 3
  • DNA-Directed RNA Polymerase III Subunit C 3 4
  • RNA Polymerase III 62 KDa Subunit 3 4
  • RNA Polymerase III Subunit C3 3 4
  • RPC62 3 4
  • DNA-Directed RNA Polymerase III Subunit RPC3 3
  • DNA-Directed III 62 KDa Polypeptide 3
  • Polymerase (RNA) III Subunit C 3
  • RPC3 3

External Ids for POLR3C Gene

Previous GeneCards Identifiers for POLR3C Gene

  • GC01M143342
  • GC01M143081
  • GC01M144303
  • GC01M145592
  • GC01M119556

Summaries for POLR3C Gene

GeneCards Summary for POLR3C Gene

POLR3C (RNA Polymerase III Subunit C) is a Protein Coding gene. Diseases associated with POLR3C include Chickenpox. Among its related pathways are Pyrimidine metabolism (KEGG) and RNA Polymerase III Transcription Initiation. GO annotations related to this gene include DNA-directed 5-3 RNA polymerase activity and RNA polymerase III activity.

UniProtKB/Swiss-Prot for POLR3C Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Gene Wiki entry for POLR3C Gene

Additional gene information for POLR3C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR3C Gene

Genomics for POLR3C Gene

Regulatory Elements for POLR3C Gene

Enhancers for POLR3C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H146034 1.5 ENCODE dbSUPER 108.2 +213.5 213483 5 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ZFP41 MEF2D SSRP1 PIAS3 POLR3C NBPF20 GPR89A GNRHR2 NUDT17 ENSG00000213240 ANKRD35 TXNIP PEX11B
GH01H146050 1.7 Ensembl ENCODE dbSUPER 75.9 +227.6 227640 2 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 ZC3H11A MEF2D SSRP1 POLR3C PIAS3 NBPF20 ENSG00000213240 ANKRD35 LINC01719 GPR89A RNVU1-6 GC01M146050
GH01H145990 1.8 FANTOM5 ENCODE dbSUPER 55.1 +171.3 171274 10 MLX FEZF1 DMAP1 YY1 SLC30A9 NFYC MEF2D SSRP1 ZNF610 RCOR2 POLR3C LIX1L-AS1 NBPF20 PIAS3 ENSG00000213240 TXNIP HFE2 RBM8A GPR89A PEX11B
GH01H144997 1.6 Ensembl ENCODE dbSUPER 60.8 -824.5 -824548 4 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF766 PIAS3 POLR3C NBPF20 GPR89A PFN1P6 ENSG00000224363 NBPF25P NUDT17 LOC645166 LIX1L-AS1
GH01H144994 1.5 Ensembl ENCODE dbSUPER 53.5 -828.4 -828388 2 PKNOX1 FEZF1 ZNF48 FOS ZNF548 YY2 ZNF662 REST KAT8 GLIS1 PIAS3 POLR3C NBPF20 PFN1P6 GPR89A LOC645166 NUDT17 LIX1L-AS1 GNRHR2 ENSG00000271644
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLR3C on UCSC Golden Path with GeneCards custom track

Promoters for POLR3C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000012925 -169 2601 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1

Genomic Location for POLR3C Gene

Chromosome:
1
Start:
145,824,069 bp from pter
End:
145,844,402 bp from pter
Size:
20,334 bases
Orientation:
Plus strand

Genomic View for POLR3C Gene

Genes around POLR3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR3C Gene

Proteins for POLR3C Gene

  • Protein details for POLR3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUI4-RPC3_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC3
    Protein Accession:
    Q9BUI4
    Secondary Accessions:
    • O15317
    • Q9Y3R6

    Protein attributes for POLR3C Gene

    Size:
    534 amino acids
    Molecular mass:
    60612 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex. Interacts with GTF3C4 (By similarity).
    Miscellaneous:
    • Antibodies against POLR3C have been found in the sera of patients with systemic sclerosis (SSc).

    Three dimensional structures from OCA and Proteopedia for POLR3C Gene

neXtProt entry for POLR3C Gene

Post-translational modifications for POLR3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POLR3C Gene

No data available for DME Specific Peptides for POLR3C Gene

Domains & Families for POLR3C Gene

Gene Families for POLR3C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for POLR3C Gene

Graphical View of Domain Structure for InterPro Entry

Q9BUI4

UniProtKB/Swiss-Prot:

RPC3_HUMAN :
  • Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
Family:
  • Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR3C: view

Function for POLR3C Gene

Molecular function for POLR3C Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Phenotypes From GWAS Catalog for POLR3C Gene

Gene Ontology (GO) - Molecular Function for POLR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001056 contributes_to RNA polymerase III activity IBA --
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding IDA 21358628
GO:0003899 DNA-directed 5-3 RNA polymerase activity TAS 9171375
GO:0005515 protein binding IPI 21358628
genes like me logo Genes that share ontologies with POLR3C: view
genes like me logo Genes that share phenotypes with POLR3C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for POLR3C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POLR3C Gene

Localization for POLR3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR3C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR3C gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for POLR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005666 DNA-directed RNA polymerase III complex IDA,TAS 24107381
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR3C: view

Pathways & Interactions for POLR3C Gene

genes like me logo Genes that share pathways with POLR3C: view

Gene Ontology (GO) - Biological Process for POLR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006359 regulation of transcription from RNA polymerase III promoter TAS 9171375
GO:0006383 transcription from RNA polymerase III promoter IEA --
GO:0032481 positive regulation of type I interferon production TAS --
genes like me logo Genes that share ontologies with POLR3C: view

No data available for SIGNOR curated interactions for POLR3C Gene

Drugs & Compounds for POLR3C Gene

(4) Drugs for POLR3C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for POLR3C Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with POLR3C: view

Transcripts for POLR3C Gene

Unigene Clusters for POLR3C Gene

Polymerase (RNA) III (DNA directed) polypeptide C (62kD):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for POLR3C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for POLR3C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ·
SP1: - - - - -
SP2: - - -
SP3: - - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: -
SP7:
SP8: - - -
SP9:

ExUns: 18c ^ 19
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for POLR3C Gene

GeneLoc Exon Structure for
POLR3C
ECgene alternative splicing isoforms for
POLR3C

Expression for POLR3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR3C Gene

Protein differential expression in normal tissues from HIPED for POLR3C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.2), Testis (11.0), and CD8 Tcells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POLR3C Gene



Protein tissue co-expression partners for POLR3C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLR3C Gene:

POLR3C

SOURCE GeneReport for Unigene cluster for POLR3C Gene:

Hs.591457
genes like me logo Genes that share expression patterns with POLR3C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR3C Gene

Orthologs for POLR3C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR3C 33 34
  • 99.88 (n)
dog
(Canis familiaris)
Mammalia POLR3C 33 34
  • 92.63 (n)
cow
(Bos Taurus)
Mammalia POLR3C 33 34
  • 92.12 (n)
rat
(Rattus norvegicus)
Mammalia Polr3c 33
  • 87.93 (n)
mouse
(Mus musculus)
Mammalia Polr3c 33 16 34
  • 87.18 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 87 (a)
OneToMany
-- 34
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia POLR3C 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr3c 33
  • 72.34 (n)
Str.5213 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.26628 33
zebrafish
(Danio rerio)
Actinopterygii polr3c 33 34
  • 64.71 (n)
zgc56348 33
fruit fly
(Drosophila melanogaster)
Insecta CG12267 33 34
  • 46.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002394 33
  • 44.97 (n)
worm
(Caenorhabditis elegans)
Secernentea C48E7.2 33 34
  • 42.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPC82 34 36
  • 16 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G49000 33
  • 41.82 (n)
rice
(Oryza sativa)
Liliopsida Os01g0679000 33
  • 38.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11029 33
Species where no ortholog for POLR3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR3C Gene

ENSEMBL:
Gene Tree for POLR3C (if available)
TreeFam:
Gene Tree for POLR3C (if available)

Paralogs for POLR3C Gene

No data available for Paralogs for POLR3C Gene

Variants for POLR3C Gene

Sequence variations from dbSNP and Humsavar for POLR3C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000041580 -- 145,824,099(+) ACAAA(C/T)GGCCC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000073992 -- 145,823,949(+) TGCAG(G/T)CGTCG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000137256 -- 145,831,000(+) GGGCT(A/G)AGGTG intron-variant
rs1000431646 -- 145,829,965(+) TGTTT(A/G)TCTAA intron-variant
rs1000777793 -- 145,842,081(+) ACGTT(C/T)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR3C Gene

Variant ID Type Subtype PubMed ID
dgv331n100 CNV gain 25217958
dgv33n27 CNV loss 19166990
dgv531n54 CNV loss 21841781
esv3572008 CNV gain 25503493
esv3587420 CNV gain 21293372
esv3894089 CNV loss 25118596
nsv1005055 CNV loss 25217958
nsv1015025 CNV gain 25217958
nsv831381 CNV gain 17160897

Variation tolerance for POLR3C Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR3C Gene

Human Gene Mutation Database (HGMD)
POLR3C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR3C Gene

Disorders for POLR3C Gene

MalaCards: The human disease database

(1) MalaCards diseases for POLR3C Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
chickenpox
  • varicella
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POLR3C

Human Genome Epidemiology (HuGE) Navigator
POLR3C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR3C
genes like me logo Genes that share disorders with POLR3C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR3C Gene

Publications for POLR3C Gene

  1. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PMID: 12391170) Hu P … Hernandez N (Molecular and cellular biology 2002) 2 3 4 60
  2. Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation. (PMID: 9171375) Wang Z … Roeder RG (Genes & development 1997) 2 3 4 60
  3. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. (PMID: 19609254) Ablasser A … Hornung V (Nature immunology 2009) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay. (PMID: 12384934) Kuwana M … Kawakami Y (Arthritis and rheumatism 2002) 3 4 60

Products for POLR3C Gene

Sources for POLR3C Gene

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