POLR3B Gene
protein-coding GIFtS: 60
GCID: GC12P106751
|
|
polymerase (RNA) III (DNA directed) polypeptide B
| |
Aliases
for POLR3B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Polymerase (RNA) III (DNA Directed) Polypeptide B1 2 | | RNA Polymerase III Subunit C22 3 | | RPC21 2 | | EC 2.7.7.63 8 | | C1282 3 | | FLJ103881 | | DNA-Directed RNA Polymerase III 127.6 KDa Polypeptide2 3 | | HLD82 | | DNA-Directed RNA Polymerase III Subunit B2 3 | | DNA-Directed RNA Polymerase III Subunit RPC22 |
Export aliases for POLR3B gene to outside databasesPrevious GC identifers: GC12P105254 GC12P105255 GC12P103811 |
Summaries
for POLR3B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for POLR3B:
This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizingtransfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic centerof RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively splicedtranscript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Dec 2011)
UniProtKB/Swiss-Prot: RPC2_HUMAN, Q9NW08Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleosidetriphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active centertogether with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element withthe central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays akey role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolicDNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription intodsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type Iinterferon and NF- Kappa-B through the RIG-I pathway
|
Genomic Views
for POLR3B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the POLR3B gene promoter:
AREB6 C/EBPbeta AML1a AP-1 POU2F1 POU2F1a POU2F1b HOXA5 POU2F1c FOXO3b
Other transcription factors
Search SABiosciences Chromatin IP Primers for POLR3B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLR3B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q23.3 Ensembl cytogenetic band: 12q23.3 HGNC cytogenetic band: 12q24POLR3B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P106751: view genomic region
(about GC identifiers)
Start:
|
106,751,436 bp from pter |
End:
|
106,903,976 bp from pter |
Size:
|
152,541 bases |
Orientation:
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plus strand |
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Proteins
for POLR3B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RPC2_HUMAN, Q9NW08 (See
protein sequence)Recommended Name: DNA-directed RNA polymerase III subunit RPC2 Size: 1133 amino acids; 127785 Da
Subunit: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAA91527.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAA91581.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K6H0 B3KV73 F5H1E6 Q9NW59Alternative splicing: 2 isoforms: Q9NW08-1 Q9NW08-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for POLR3B: NX_Q9NW08
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NW08
4/17 DME Specific Peptides for POLR3B (Q9NW08) (see all 17)
POLR3B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001154180.1 NP_060552.4
ENSEMBL proteins: ENSP00000228347 ENSP00000448539 ENSP00000445721 ENSP00000448398 ENSP00000448498 Reactome Protein details: Q9NW08
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005654 | nucleoplasm |
TAS | -- |
POLR3B for ontologies About GeneDecksing
POLR3B Antibody Products:
Assay Products for POLR3B: |
Protein
Domains /
Families
for POLR3B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
POLR3B for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry Q9NW08ProtoNet protein and cluster: Q9NW08 2 Blocks protein families: IPB007646 RNA polymerase Rpb2 IPB007647 RNA polymerase Rpb2
UniProtKB/Swiss-Prot: RPC2_HUMAN, Q9NW08Similarity: Belongs to the RNA polymerase beta chain family |
Function
for POLR3B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RPC2_HUMAN, Q9NW08Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleosidetriphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active centertogether with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element withthe central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays akey role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolicDNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription intodsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type Iinterferon and NF- Kappa-B through the RIG-I pathwayCatalytic activity: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)Enzyme Number (IUBMB): EC 2.7.7.61 2
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLR3B (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR3B |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
POLR3B for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for POLR3B:
|
Pathways & Interactions
for POLR3B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | RNA Polymerase III Transcription Initiation | | | 2 | ATP/ITP metabolism | | | 3 | Purine metabolism | | | 4 | Transcription | | | 5 | Cytosolic DNA-sensing pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for POLR3B
1  GeneGo (Thomson Reuters) Pathway for POLR3B
1  BioSystems Pathway for POLR3B
5/11 
Reactome Pathways for POLR3B (see all 11)
5 
Kegg Pathways (Kegg details for POLR3B):
POLR3B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POLR3B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/193 Interacting proteins for POLR3B (Q9NW083 ENSP000002283474) via UniProtKB, MINT, STRING, and/or I2D (see all 193)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006383 | transcription from RNA polymerase III promoter |
TAS | -- | | GO:0006385 | transcription elongation from RNA polymerase III promoter |
TAS | -- | | GO:0006386 | termination of RNA polymerase III transcription |
TAS | -- | | GO:0009615 | response to virus |
-- | -- | | GO:0010467 | gene expression |
TAS | -- |
POLR3B for ontologies About GeneDecksing
|
Drugs & Compounds
for POLR3B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for POLR3B
4 HMDB Compounds for POLR3B About this table
Search CenterWatch for drugs/clinical trials and news about POLR3B / RPC2
|
Transcripts
for POLR3B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for POLR3B gene (2 alternative transcripts): NM_001160708.1 NM_018082.5 Unigene Clusters for POLR3B: Polymerase (RNA) III (DNA directed) polypeptide B Hs.62696 [show with all ESTs], Hs.610795 [show with all ESTs]Unigene Representative Sequences: NM_018082, BC0335425 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000228347(uc001tlp.3) ENST00000551370 ENST00000539066(uc001tlq.3)
ENST00000549569 ENST00000549195
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLR3B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLR3B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): POLR3B (NM_018082) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POLR3B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR3B |
Additional cDNA sequence: BC033542.1 7 DOTS entries: DT.406080 DT.100778661 DT.99944362 DT.101973149 DT.97762598 DT.121150665 DT.92407267 24/104 AceView cDNA sequences (see all 104): BE263182 AK122713 BX648712 BM788368 BC017501 AX746551 AW196487 AU123324 BX537447 BC046238 AK092031 CR595354 NM_018082 AK090636 AY092084 AK001250 AI755102 AX747324 BU155606 AI651396 BE855968 BX107499 BU729867 N75936
GeneLoc Exon Structure
|
Expression
for POLR3B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| POLR3B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAAATTTA
About this image
See POLR3B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POLR3B
SOURCE GeneReport for Unigene clusters: Hs.62696 Hs.610795
SABiosciences Custom PCR Arrays for POLR3B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLR3B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POLR3B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR3B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR3B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR3B |
Orthologs
for POLR3B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for POLR3B gene from 10/42 species (see all 42) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
POLR3B1 |
polymerase (RNA) III (DNA directed) polypeptide B |
83.63(n)
97.08(a) |
|
418071 XM_416307.3 XP_416307.3 |
lizard
(Anolis carolinensis) |
Reptilia |
POLR3B6 |
-- |
97(a) |
1 ↔ 1 |
5(19168211-19228838) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.37622 |
Transcribed sequence with weak similarity to protein more |
80.24(n) |
|
BX743116.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
570518882 |
-- |
77.98(n) |
|
57051888 |
fruit fly
(Drosophila melanogaster) |
Insecta |
RpIII1281 |
RNA polymerase III 128kD subunit |
63.73(n)
69.49(a) |
|
36289 NM_078982.2 NP_523706.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
F09F7.31 |
Protein F09F7.3 |
61.33(n)
64.81(a) |
|
175767 NM_065791.6 NP_498192.2 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
RET1(YOR207C)4
RET11 |
Second-largest subunit of RNA polymerase III, which more4
Ret1p1 |
61.39(n)1
63.92(a)1 |
|
15(733457-730008)4
8543821, 4 NP_014850.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
NRPC21 |
DNA-directed RNA polymerase III subunit C2 |
58.53(n)
58.41(a) |
|
834550 NM_123882.4 NP_199327.4 |
rice
(Oryza sativa) |
Liliopsida |
Os.232032 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
73.59(n) |
|
AK073203.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
rpoB6 |
RNA polymerase, beta subunit |
16(a) |
1 → many |
Chromosome(4179268-4183296) |
ENSEMBL Gene Tree for POLR3B (if available)
TreeFam Gene Tree for POLR3B (if available) |
Paralogs
for POLR3B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for POLR3B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for POLR3B (106751436 - 106903976 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for POLR3B: --
Human Gene Mutation Database (HGMD): POLR3B
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POLR3B |
|
Disorders
/ Diseases
for POLR3B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
POLR3B for disorders About GeneDecksing
OMIM gene information: 614366
OMIM disorders: --
UniProtKB/Swiss-Prot: RPC2_HUMAN, Q9NW08
Defects in POLR3B are the cause of leukodystrophy, hypomyelinating, type 8, with or without oligodontia and/orhypogonadotropic hypogonadism (HLD8) [MIM:614381]. An autosomal recessive neurodegenerative disorder characterized byearly childhood onset of cerebellar ataxia and mild intellectual disabilities associated with diffuse hypomyelinationapparent on brain MRI. Variable features include oligodontia and/or hypogonadotropic hypogonadism
14  diseases for POLR3B: About MalaCardsleukodystrophy oligodontia intellectual disability esotropia
cerebellar ataxia histoplasmosis hypogonadotropism hypogonadism
ataxia pneumonia tuberculosis immunodeficiency
malaria mycobacterium tuberculosis
2 diseases from the University of Copenhagen DISEASES database for POLR3B:Histoplasmosis Klinefelter's syndrome Human Genome Epidemiology (HuGE) Navigator: POLR3B (1 document)
Export disorders for POLR3B gene to outside databases
|
Publications
for POLR3B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for POLR3B gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with POLR3B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PubMed id 12391170)1, 2, 3 Hu P....Hernandez N. (2002)
- Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy. (PubMed id 22036171)1, 2 Saitsu H.... Matsumoto N. (2011)
- Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy. (PubMed id 22036172)1, 2 Tetreault M....Bernard G. (2011)
- RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. (PubMed id 19609254)1, 2 Ablasser A....Hornung V. (2009)
- RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. (PubMed id 19631370)1, 2 Chiu Y.-H.... Chen Z.J. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Genome-wide association study of Tourette's syndrome. (PubMed id 22889924)1 Scharf J.M.... D.L. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for POLR3B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing POLR3B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing POLR3B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing POLR3B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for POLR3B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for POLR3B gene:
Search GeneIP for patents involving POLR3B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for POLR3B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for POLR3B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLR3B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLR3B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for POLR3B | | OriGene 3'-UTR Clone for POLR3B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLR3B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLR3B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for POLR3B | | OriGene Custom Protein Services for POLR3B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POLR3B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POLR3B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLR3B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLR3B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR3B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR3B |
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| | | | Search Tocris compounds for POLR3B |
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 | | | POLR3B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR3B |
|  |  |  | | | | Search ThermoFisher Antibodies for POLR3B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR3B |
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