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Aliases for POLR2M Gene

Aliases for POLR2M Gene

  • Polymerase (RNA) II (DNA Directed) Polypeptide M 2 3
  • Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate-Like 1A 2 3
  • DNA-Directed RNA Polymerase II Subunit M, Isoforms 4/5 3 4
  • GRINL1A 3 4
  • DNA-Directed RNA Polymerase II Subunit M 4
  • Glutamate Receptor-Like Protein 1A 4
  • GRINL1A Downstream Protein Gdown4 3
  • Protein GRINL1A, Isoforms 4/5 3
  • Gdown1 3
  • GCOM1 3
  • Gdown 3

External Ids for POLR2M Gene

Previous HGNC Symbols for POLR2M Gene

  • GRINL1A

Previous GeneCards Identifiers for POLR2M Gene

  • GC15P057888

Summaries for POLR2M Gene

Entrez Gene Summary for POLR2M Gene

  • This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented with GeneID 145781. [provided by RefSeq, Oct 2013]

GeneCards Summary for POLR2M Gene

POLR2M (Polymerase (RNA) II (DNA Directed) Polypeptide M) is a Protein Coding gene. GO annotations related to this gene include DNA-directed RNA polymerase activity. An important paralog of this gene is GCOM1.

UniProtKB/Swiss-Prot for POLR2M Gene

  • Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.

Gene Wiki entry for POLR2M Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2M Gene

Genomics for POLR2M Gene

Genomic Location for POLR2M Gene

Chromosome:
15
Start:
57,706,521 bp from pter
End:
57,782,762 bp from pter
Size:
76,242 bases
Orientation:
Plus strand

Genomic View for POLR2M Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POLR2M Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2M Gene

No data available for Regulatory Elements for POLR2M Gene

Proteins for POLR2M Gene

  • Protein details for POLR2M Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CAP2-GRL1A_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit GRINL1A
    Protein Accession:
    P0CAP2
    Secondary Accessions:
    • Q6EER8
    • Q6EES2
    • Q6EEV3
    • Q6EF00
    • Q6EF01
    • Q6EF02
    • Q6EF46
    • Q6EFN8
    • Q6EM48
    • Q6K046
    • Q6K050
    • Q6K051
    • Q6ZQZ3
    • Q8NC58
    • Q8NCF3
    • Q96DI5
    • Q96JB7
    • Q96NF5
    • Q9Y3V6

    Protein attributes for POLR2M Gene

    Size:
    368 amino acids
    Molecular mass:
    41740 Da
    Quaternary structure:
    • Isoform 1 is a component of the Pol II(G) complex, which contains the RNA polymerase II (Pol II) core complex subunits and POLR2M isoform 1. Pol II(G) appears to be an abundant form of Pol II
    Miscellaneous:
    • The adjacent MYZAP and POLR2M genes are part of a complex transcription unit. The respective transcripts derive from different promoters and are alternatively spliced. In human, some transcripts of the upstream promoter of MYZAP use exons of the downstream POLR2M gene

    Alternative splice isoforms for POLR2M Gene

  • Protein details for POLR2M Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6EEV4-GL1AD_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5
    Protein Accession:
    Q6EEV4
    Secondary Accessions:
    • Q6EEV7

    Protein attributes for POLR2M Gene

    Size:
    148 amino acids
    Molecular mass:
    15131 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The adjacent MYZAP and POLR2M genes are part of a complex transcription unit. The respective transcripts derive from different promoters and are alternatively spliced. In human, some transcripts of the upstream promoter of MYZAP use exons of the downstream POLR2M gene

    Alternative splice isoforms for POLR2M Gene

neXtProt entry for POLR2M Gene

Proteomics data for POLR2M Gene at MOPED

Post-translational modifications for POLR2M Gene

Other Protein References for POLR2M Gene

No data available for DME Specific Peptides for POLR2M Gene

Domains & Families for POLR2M Gene

Gene Families for POLR2M Gene

Protein Domains for POLR2M Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P0CAP2

UniProtKB/Swiss-Prot:

GL1AD_HUMAN :
  • Belongs to the GRINL1 family.
Family:
  • Belongs to the GRINL1 family.
genes like me logo Genes that share domains with POLR2M: view

Function for POLR2M Gene

Molecular function for POLR2M Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.

Gene Ontology (GO) - Molecular Function for POLR2M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003899 DNA-directed RNA polymerase activity IEA --
genes like me logo Genes that share ontologies with POLR2M: view

Phenotypes for POLR2M Gene

GenomeRNAi human phenotypes for POLR2M:
genes like me logo Genes that share phenotypes with POLR2M: view

Animal Model Products

CRISPR Products

miRNA for POLR2M Gene

miRTarBase miRNAs that target POLR2M

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POLR2M

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2M Gene

Localization for POLR2M Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2M Gene

Isoform 1: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR2M Gene COMPARTMENTS Subcellular localization image for POLR2M gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for POLR2M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IDA --
GO:0016591 DNA-directed RNA polymerase II, holoenzyme IDA 22231121
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with POLR2M: view

Pathways & Interactions for POLR2M Gene

SuperPathways for POLR2M Gene

No Data Available

Interacting Proteins for POLR2M Gene

Gene Ontology (GO) - Biological Process for POLR2M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032774 RNA biosynthetic process IEA --
GO:0051685 maintenance of ER location IEA --
genes like me logo Genes that share ontologies with POLR2M: view

No data available for Pathways by source and SIGNOR curated interactions for POLR2M Gene

Drugs & Compounds for POLR2M Gene

No Compound Related Data Available

Transcripts for POLR2M Gene

Unigene Clusters for POLR2M Gene

Polymerase (RNA) II (DNA directed) polypeptide M:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POLR2M

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2M Gene

No ASD Table

Relevant External Links for POLR2M Gene

GeneLoc Exon Structure for
POLR2M
ECgene alternative splicing isoforms for
POLR2M

Expression for POLR2M Gene

mRNA expression in normal human tissues for POLR2M Gene

Protein differential expression in normal tissues from HIPED for POLR2M Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.4), Fetal Brain (6.9), and Cerebral cortex (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLR2M Gene



SOURCE GeneReport for Unigene cluster for POLR2M Gene Hs.437256

mRNA Expression by UniProt/SwissProt for POLR2M Gene

P0CAP2-GRL1A_HUMAN
Tissue specificity: Detected in adult an fetal brain. Detected in heart, kidney, skeletal muscle, small intestine, lung, prostate and testis.
genes like me logo Genes that share expression patterns with POLR2M: view

Protein tissue co-expression partners for POLR2M Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for POLR2M Gene

Orthologs for POLR2M Gene

This gene was present in the common ancestor of chordates.

Orthologs for POLR2M Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POLR2M 35
  • 81.94 (n)
  • 73.37 (a)
POLR2M 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR2M 35
  • 86.74 (n)
  • 79.27 (a)
POLR2M 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr2m 35
  • 79.81 (n)
  • 72.11 (a)
Polr2m 16
Polr2m 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLR2M 35
  • 98.68 (n)
  • 98.02 (a)
rat
(Rattus norvegicus)
Mammalia Polr2m 35
  • 80.72 (n)
  • 72.93 (a)
oppossum
(Monodelphis domestica)
Mammalia POLR2M 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 8 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia POLR2M 36
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grinl1a 35
  • 52.49 (n)
  • 43.18 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100003720 35
  • 49.35 (n)
  • 40.32 (a)
POLR2M 36
  • 31 (a)
OneToOne
Species with no ortholog for POLR2M:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POLR2M Gene

ENSEMBL:
Gene Tree for POLR2M (if available)
TreeFam:
Gene Tree for POLR2M (if available)

Paralogs for POLR2M Gene

Paralogs for POLR2M Gene

(3) SIMAP similar genes for POLR2M Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for POLR2M Gene

genes like me logo Genes that share paralogs with POLR2M: view

Variants for POLR2M Gene

Sequence variations from dbSNP and Humsavar for POLR2M Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
VAR_054029 -

Variation tolerance for POLR2M Gene

Residual Variation Intolerance Score: 82.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR2M Gene

HapMap Linkage Disequilibrium report
POLR2M
Human Gene Mutation Database (HGMD)
POLR2M

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for POLR2M Gene

Disorders for POLR2M Gene

Relevant External Links for POLR2M

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2M
genes like me logo Genes that share disorders with POLR2M: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR2M Gene

Publications for POLR2M Gene

  1. Regulation of mammalian transcription by Gdown1 through a novel steric crosstalk revealed by cryo-EM. (PMID: 22850672) Wu Y.M. … Chang W.H. (EMBO J. 2012) 2 67
  2. Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A. (PMID: 20412299) Garcia-Mayoral M.F. … Bruix M. (FEBS J. 2010) 23 67
  3. A Mediator-responsive form of metazoan RNA polymerase II. (PMID: 16769904) Hu X. … Gnatt A. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Regulation of RNA polymerase II termination by phosphorylation of Gdown1. (PMID: 24634214) Guo J. … Price D.H. (J. Biol. Chem. 2014) 67

Products for POLR2M Gene

Sources for POLR2M Gene

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