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POLR2M Gene

protein-coding   GIFtS: 43
GCID: GC15P057888

Polymerase (RNA) II (DNA Directed) Polypeptide M

(Previous names: glutamate receptor, ionotropic, N-methyl D-aspartate-like...)
(Previous symbol: GRINL1A)
  Search for POLR2M
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Polymerase (RNA) II (DNA Directed) Polypeptide M1 2     GRINL1A Downstream Protein Gdown42
GRINL1A1 2 3 5     Protein GRINL1A2
Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate-Like 1A1 2     Protein GRINL1A, Isoforms 4/52
DNA-Directed RNA Polymerase II Subunit M, Isoforms 4/52 3     DNA-Directed RNA Polymerase II Subunit M3
GCOM12     Glutamate Receptor-Like Protein 1A3
Gdown2     GDOWN5
Gdown12     

External Ids:    HGNC: 148621   Entrez Gene: 814882   Ensembl: ENSG000002555297   OMIM: 6064855   UniProtKB: Q6EEV43   
UniProtKB: P0CAP23   

Export aliases for POLR2M gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POLR2M Gene:
This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act
as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in
multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription
between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented
with GeneID 145781. (provided by RefSeq, Oct 2013)

GeneCards Summary for POLR2M Gene:
POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) is a protein-coding gene. GO annotations related to this gene include DNA-directed RNA polymerase activity. An important paralog of this gene is TUFT1.

UniProtKB/Swiss-Prot: GRL1A_HUMAN, P0CAP2
Function: Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II).
Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal
RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation
of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this
repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a
level equivalent to that of Pol II

Gene Wiki entry for POLR2M (GRINL1A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for POLR2M
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): POLR2M promoter sequence
   Search Chromatin IP Primers for POLR2M

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POLR2M


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.3   Ensembl cytogenetic band:  15q21.3   HGNC cytogenetic band: 15q21.3

POLR2M Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR2M gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P057888:  view genomic region     (about GC identifiers)

Start:
57,884,231 bp from pter      End:
58,074,960 bp from pter
Size:
190,730 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GL1AD_HUMAN, Q6EEV4 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5  
Size: 148 amino acids; 15131 Da
Miscellaneous: The adjacent MYZAP and POLR2M genes are part of a complex transcription unit. The respective
transcripts derive from different promoters and are alternatively spliced. In human, some transcripts of the
upstream promoter of MYZAP use exons of the downstream POLR2M gene
Secondary accessions: Q6EEV7
Alternative splicing: 6 isoforms:  Q6EEV4-1   P0CAP2-1   P0CAP2-2   P0CAP2-3   Q6EEV4-2   P0CAP1-11   (Based on a naturally occurring readthrough transcript which produces a MYZAP-POLR2M fusion protein)

UniProtKB/Swiss-Prot: GRL1A_HUMAN, P0CAP2 (See protein sequence)

Recommended Name: DNA-directed RNA polymerase II subunit GRINL1A  
Size: 368 amino acids; 41740 Da
Subunit: Isoform 1 is a component of the Pol II(G) complex, which contains the RNA polymerase II (Pol II) core
complex subunits and POLR2M isoform 1. Pol II(G) appears to be an abundant form of Pol II
Miscellaneous: The adjacent MYZAP and POLR2M genes are part of a complex transcription unit. The respective
transcripts derive from different promoters and are alternatively spliced. In human, some transcripts of the
upstream promoter of MYZAP use exons of the downstream POLR2M gene
Secondary accessions: Q6EER8 Q6EES2 Q6EEV3 Q6EF00 Q6EF01 Q6EF02 Q6EF46 Q6EFN8 Q6EM48 Q6K046
Q6K050 Q6K051 Q6ZQZ3 Q8NC58 Q8NCF3 Q96DI5 Q96JB7 Q96NF5 Q9Y3V6
Alternative splicing: 6 isoforms:  P0CAP2-1   P0CAP2-2   P0CAP2-3   Q6EEV4-1   Q6EEV4-2   P0CAP1-11   (Based on a naturally occurring readthrough transcript which produces a MYZAP-POLR2M fusion protein)

Explore the universe of human proteins at neXtProt for POLR2M: NX_P0CAP2

Explore proteomics data for POLR2M at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus (GRINL1A)

  • See POLR2M Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001018112.1  NP_056347.1  

    ENSEMBL proteins: 
     ENSP00000299638   ENSP00000433988   ENSP00000437015   ENSP00000432615   ENSP00000369930  
     ENSP00000369937  

    POLR2M Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POLR: RNA polymerase subunits

    1 InterPro protein domain:
     IPR026213 GRINL1

    Graphical View of Domain Structure for InterPro Entry Q6EEV4
    Graphical View of Domain Structure for InterPro Entry P0CAP2

    ProtoNet protein and cluster: Q6EEV4

    UniProtKB/Swiss-Prot: GRL1A_HUMAN, P0CAP2
    Similarity: Belongs to the GRINL1 family


    Find genes that share domains with POLR2M           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRL1A_HUMAN, P0CAP2
    Function: Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II).
    Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal
    RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation
    of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this
    repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a
    level equivalent to that of Pol II

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003899DNA-directed RNA polymerase activity IEA--
         
    Find genes that share ontologies with POLR2M           About GenesLikeMe


    Animal Models:
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    miRNA
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    hsa-mir-331-3p (MIRT043380)

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    SwitchGear 3'UTR luciferase reporter plasmidPOLR2M 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GRL1A_HUMAN, P0CAP2: Isoform 1: Nucleus (Probable)

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IDA--
    GO:0016591DNA-directed RNA polymerase II, holoenzyme IDA--
    GO:0043025neuronal cell body IEA--

    Find genes that share ontologies with POLR2M           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POLR2M
    Interactions:

        Search GeneGlobe Interaction Network for POLR2M

    Selected Interacting proteins for POLR2M (P0CAP23) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AHSPQ9NZD43I2D: score=3 
    APODP050903I2D: score=3 
    CEBPGP535673I2D: score=3 
    HIGD1BQ9P2983I2D: score=3 
    KIAA1377Q9P2H03I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051685maintenance of ER location IEA--

    Find genes that share ontologies with POLR2M           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POLR2M (GRL1A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for POLR2M gene (2 alternative transcripts): 
    NM_001018102.2  NM_015532.4  

    Unigene Cluster for POLR2M:

    Polymerase (RNA) II (DNA directed) polypeptide M
    Hs.437256  [show with all ESTs]
    Unigene Representative Sequence: NM_001018090
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299638(uc002aem.3 uc002aep.3 uc010bfx.3 uc002aeq.3 uc002aen.3 uc010bfy.3 uc002aeo.3 uc002aes.3 uc010ugu.2 uc002aet.4 uc002aeu.4)
    ENST00000494490(uc002aev.1) ENST00000464277 ENST00000482852 ENST00000567643
    ENST00000380557 ENST00000464308 ENST00000562260 ENST00000380563
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat POLR2M
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    Additional mRNA sequence: 

    AF086209.1 AF326773.1 AK055535.1 AK074767.1 AK074955.1 AK128618.1 AK223571.1 AK308873.1 
    AL050091.1 AL833028.1 AL833142.1 AY207007.1 AY207459.1 AY208913.1 AY237639.1 AY339380.1 
    AY341344.1 AY353061.1 AY620236.1 BC001510.2 BC050322.1 BC101645.1 BC112148.1 FJ970029.1 
    JF419331.1 NR_027390.1 

    Selected DOTS entries (see all 25):

    DT.92439463  DT.97778662  DT.444826  DT.445427  DT.102829994  DT.100020059  DT.99967845  DT.95194234 
    DT.121054112  DT.95156424  DT.100805929  DT.100059260  DT.100723128  DT.100810013  DT.121054114  DT.121054154 
    DT.121054217  DT.121222449  DT.121222475  DT.40109899  DT.95156423  DT.95194247  DT.121222489  DT.121222490 

    Selected AceView cDNA sequences (see all 384):

    AI964034 AI440463 BU621381 BE464851 AY237639 AA579970 BU164049 CD637834 
    AI332865 N50877 BM714319 AY334562 AI862730 AF326773 AA620319 AA961535 
    AA890165 CA390330 BM785986 BM990560 AI685856 AY334560 AI801462 AI375286 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    POLR2M expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTAATAA
    POLR2M Expression
    About this image

    POLR2M Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POLR2M Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437256

    UniProtKB/Swiss-Prot: GRL1A_HUMAN, P0CAP2
    Tissue specificity: Detected in adult an fetal brain. Detected in heart, kidney, skeletal muscle, small intestine,
    lung, prostate and testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for POLR2M gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Polr2m1 , 5 polymerase (RNA) II (DNA directed) polypeptide M1, 5 79.81(n)1
    72.11(a)1
      9 (39.85 cM)5
    280151  NM_178602.31  NP_848717.11 
     714784375 
    lizard
    (Anolis carolinensis)
    Reptilia POLR2M6
    polymerase (RNA) II (DNA directed) polypeptide M
    30(a)
    1 ↔ 1
    GL343573.1(305930-311662)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia grinl1a1 glutamate receptor, ionotropic, N-methyl D-aspartate-like more 52.49(n)
    43.18(a)
      100379989  NM_001205244.1  NP_001192173.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000037201 DNA-directed RNA polymerase II subunit GRINL1A-like 49.35(n)
    40.32(a)
      100003720  XM_001343168.4  XP_001343204.1 


    ENSEMBL Gene Tree for POLR2M (if available)
    TreeFam Gene Tree for POLR2M (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for POLR2M gene
    TUFT12  GCOM12  MYZAP2  
    3 SIMAP similar genes for POLR2M using alignment to 3 protein entries:     GL1AD_HUMAN (see all proteins):
    GRINL1A    GCOM2    GCOM1

    Find genes that share paralogs with POLR2M           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for POLR2M
    PGOHUM00000238892


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POLR2M (see all 362)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs592943381,2
    C--34829037(+) TTCTTC/TTTTTT 3 -- int10--------
    rs286987411,2
    C--34833083(+) TTTGTG/TTGTGT 3 -- ds50012Minor allele frequency- T:0.25NA CSA 4
    rs783072411,2
    F--38059063(+) GTCCTC/TCAAAT 3 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1842549891,2
    --38059073(+) TTTAAA/CCTAAA 3 -- us2k10--------
    rs43064441,2
    C,H--38059148(+) tagaaT/Cccagg 3 -- us2k14Minor allele frequency- C:0.00NS EA 414
    rs1887265061,2
    C--38059227(+) CTGAAG/TCCTGC 3 -- us2k10--------
    rs742480161,2
    C--38059341(+) TTTACC/GTATAA 3 -- us2k10--------
    rs665005201,2
    C--38059587(+) GAGTC-/TTTTTT 3 -- us2k10--------
    rs1468608981,2
    --38059671(+) AGCACG/TTTATT 3 -- us2k10--------
    rs756168201,2
    C,F--38059688(+) CTTGAA/CAGCAA 3 -- us2k12Minor allele frequency- C:0.04WA NA 238

    HapMap Linkage Disequilibrium report for POLR2M (57884231 - 58074960 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for POLR2M: --
    Human Gene Mutation Database (HGMD): POLR2M
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing POLR2M
    DNA2.0 Custom Variant and Variant Library Synthesis for POLR2M

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606485    OMIM disorders: --


    Find genes that share disorders with POLR2M           About GenesLikeMe


    Export disorders for POLR2M gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POLR2M gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with POLR2M)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A Mediator-responsive form of metazoan RNA polymerase II. (PubMed id 16769904)1, 2, 3 Hu X.... Gnatt A. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    2. Regulation of mammalian transcription by Gdown1 through a novel steric crosstalk revealed by cryo-EM. (PubMed id 22850672)1, 3 Wu Y.M....Chang W.H. (EMBO J. 2012)
    3. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)1, 2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)1, 2 Zody M.C....Nusbaum C. (Nature 2006)
    5. The human GRINL1A gene defines a complex transcription unit, an unusual form of gene organization in eukaryotes. (PubMed id 15233991)1, 2 Roginski R.S.... Rowen L. (Genomics 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S.... Conaway R.C. (Mol. Cell 2004)
    9. Assignment of an ionotropic glutamate receptor-like gene (GRINL1A) to human chromosome 15q22.1 by in situ hybridization. (PubMed id 11474202)1, 2 Roginski R.S.... Sciorra L.J. (Cytogenet. Cell Genet. 2001)
    10. Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A. (PubMed id 20412299)1, 9 Garcia-Mayoral M.F.... Bruix M. (FEBS J. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81488 HGNC: 14862 AceView: GRINL1AandGup1 Ensembl:ENSG00000255529 euGenes: HUgn81488
    ECgene: POLR2M H-InvDB: POLR2M

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for POLR2M Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for POLR2M gene:
    Search GeneIP for patents involving POLR2M

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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