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Aliases for POLR2M Gene

Aliases for POLR2M Gene

  • RNA Polymerase II Subunit M 2 3 5
  • Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate-Like 1A 2 3
  • DNA-Directed RNA Polymerase II Subunit M, Isoforms 4/5 3 4
  • Polymerase (RNA) II (DNA Directed) Polypeptide M 2 3
  • Polymerase (RNA) II Subunit M 2 3
  • GRINL1A 3 4
  • DNA-Directed RNA Polymerase II Subunit M 4
  • Glutamate Receptor-Like Protein 1A 4
  • GRINL1A Downstream Protein Gdown4 3
  • Protein GRINL1A, Isoforms 4/5 3
  • Protein GRINL1A 3
  • Gdown1 3
  • GCOM1 3
  • Gdown 3

External Ids for POLR2M Gene

Previous HGNC Symbols for POLR2M Gene

  • GRINL1A

Previous GeneCards Identifiers for POLR2M Gene

  • GC15P057888

Summaries for POLR2M Gene

Entrez Gene Summary for POLR2M Gene

  • This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented with GeneID 145781. [provided by RefSeq, Oct 2013]

GeneCards Summary for POLR2M Gene

POLR2M (RNA Polymerase II Subunit M) is a Protein Coding gene. GO annotations related to this gene include DNA-directed 5-3 RNA polymerase activity. An important paralog of this gene is GCOM1.

UniProtKB/Swiss-Prot for POLR2M Gene

  • Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.

Gene Wiki entry for POLR2M Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2M Gene

Genomics for POLR2M Gene

Regulatory Elements for POLR2M Gene

Enhancers for POLR2M Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G057560 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -145.1 -145082 2.5 CTCF HINFP JUN CEBPG ZNF644 ZNF2 RAD21 RFX5 FOSL1 EED GCOM1 POLR2M CGNL1 MYZAP RPS13P7 GC15P057580
GH15G057547 1.3 Ensembl ENCODE dbSUPER 11.5 -154.1 -154136 8.8 CTCF FOXA2 JUN TEAD4 MAX SIN3A CEBPG BRCA1 RFX5 TEAD3 GCOM1 POLR2M CGNL1 RNU6-844P MYZAP ENSG00000276772 GC15P057541
GH15G057565 1.2 Ensembl ENCODE dbSUPER 11.7 -140.2 -140159 2.3 STAT1 JUN MAX USF2 EP300 JUND CBX8 STAT3 FOS IKZF2 MYZAP GCOM1 POLR2M CGNL1 RNU6-844P RPS13P7 GC15P057580
GH15G057653 1.2 FANTOM5 ENCODE dbSUPER 10.9 -51.8 -51801 2.0 ATF1 CEBPB MAFG REST ATF2 MAFF ZFHX2 ZNF316 EGR1 TRIM24 GCOM1 POLR2M GC15M057616 GC15P057669
GH15G057705 1.4 ENCODE dbSUPER 9 +0.7 711 2.9 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF207 FOS POLR2M ENSG00000261219
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLR2M on UCSC Golden Path with GeneCards custom track

Promoters for POLR2M Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000077120 779 1801 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF207 FOS

Genomic Location for POLR2M Gene

Chromosome:
15
Start:
57,706,521 bp from pter
End:
57,782,762 bp from pter
Size:
76,242 bases
Orientation:
Plus strand

Genomic View for POLR2M Gene

Genes around POLR2M on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2M Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2M Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2M Gene

Proteins for POLR2M Gene

  • Protein details for POLR2M Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CAP2-GRL1A_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit GRINL1A
    Protein Accession:
    P0CAP2
    Secondary Accessions:
    • Q6EER8
    • Q6EES2
    • Q6EEV3
    • Q6EF00
    • Q6EF01
    • Q6EF02
    • Q6EF46
    • Q6EFN8
    • Q6EM48
    • Q6K046
    • Q6K050
    • Q6K051
    • Q6ZQZ3
    • Q8NC58
    • Q8NCF3
    • Q96DI5
    • Q96JB7
    • Q96NF5
    • Q9Y3V6

    Protein attributes for POLR2M Gene

    Size:
    368 amino acids
    Molecular mass:
    41740 Da
    Quaternary structure:
    • Isoform 1 is a component of the Pol II(G) complex, which contains the RNA polymerase II (Pol II) core complex subunits and POLR2M isoform 1. Pol II(G) appears to be an abundant form of Pol II.
    Miscellaneous:
    • The adjacent MYZAP and POLR2M genes are part of a complex transcription unit. The respective transcripts derive from different promoters and are alternatively spliced. In human, some transcripts of the upstream promoter of MYZAP use exons of the downstream POLR2M gene.

    Alternative splice isoforms for POLR2M Gene

  • Protein details for POLR2M Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6EEV4-GL1AD_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5
    Protein Accession:
    Q6EEV4
    Secondary Accessions:
    • Q6EEV7

    Protein attributes for POLR2M Gene

    Size:
    148 amino acids
    Molecular mass:
    15131 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The adjacent MYZAP and POLR2M genes are part of a complex transcription unit. The respective transcripts derive from different promoters and are alternatively spliced. In human, some transcripts of the upstream promoter of MYZAP use exons of the downstream POLR2M gene.

    Alternative splice isoforms for POLR2M Gene

neXtProt entry for POLR2M Gene

Post-translational modifications for POLR2M Gene

Other Protein References for POLR2M Gene

No data available for DME Specific Peptides for POLR2M Gene

Domains & Families for POLR2M Gene

Gene Families for POLR2M Gene

Protein Domains for POLR2M Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P0CAP2

UniProtKB/Swiss-Prot:

GL1AD_HUMAN :
  • Belongs to the GRINL1 family.
Family:
  • Belongs to the GRINL1 family.
genes like me logo Genes that share domains with POLR2M: view

Function for POLR2M Gene

Molecular function for POLR2M Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.

Gene Ontology (GO) - Molecular Function for POLR2M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003899 DNA-directed 5-3 RNA polymerase activity IEA --
genes like me logo Genes that share ontologies with POLR2M: view

Animal Model Products

CRISPR Products

miRNA for POLR2M Gene

miRTarBase miRNAs that target POLR2M

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2M Gene

Localization for POLR2M Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2M Gene

Isoform 1: Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR2M gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for POLR2M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IDA --
GO:0016591 DNA-directed RNA polymerase II, holoenzyme IDA 22231121
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with POLR2M: view

Pathways & Interactions for POLR2M Gene

SuperPathways for POLR2M Gene

No Data Available

Gene Ontology (GO) - Biological Process for POLR2M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032774 RNA biosynthetic process IEA --
GO:0051685 maintenance of ER location IBA --
genes like me logo Genes that share ontologies with POLR2M: view

No data available for Pathways by source and SIGNOR curated interactions for POLR2M Gene

Drugs & Compounds for POLR2M Gene

No Compound Related Data Available

Transcripts for POLR2M Gene

Unigene Clusters for POLR2M Gene

Polymerase (RNA) II (DNA directed) polypeptide M:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2M Gene

No ASD Table

Relevant External Links for POLR2M Gene

GeneLoc Exon Structure for
POLR2M
ECgene alternative splicing isoforms for
POLR2M

Expression for POLR2M Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR2M Gene

Protein differential expression in normal tissues from HIPED for POLR2M Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.4), Fetal Brain (6.9), and Cerebral cortex (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POLR2M Gene



Protein tissue co-expression partners for POLR2M Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLR2M Gene:

POLR2M

SOURCE GeneReport for Unigene cluster for POLR2M Gene:

Hs.437256

mRNA Expression by UniProt/SwissProt for POLR2M Gene:

P0CAP2-GRL1A_HUMAN
Tissue specificity: Detected in adult an fetal brain. Detected in heart, kidney, skeletal muscle, small intestine, lung, prostate and testis.

Evidence on tissue expression from TISSUES for POLR2M Gene

  • Heart(4)
  • Lung(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with POLR2M: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR2M Gene

Orthologs for POLR2M Gene

This gene was present in the common ancestor of chordates.

Orthologs for POLR2M Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR2M 34
  • 98.68 (n)
dog
(Canis familiaris)
Mammalia POLR2M 34 35
  • 86.74 (n)
cow
(Bos Taurus)
Mammalia POLR2M 34 35
  • 81.94 (n)
rat
(Rattus norvegicus)
Mammalia Polr2m 34
  • 80.72 (n)
mouse
(Mus musculus)
Mammalia Polr2m 34 16 35
  • 79.81 (n)
oppossum
(Monodelphis domestica)
Mammalia POLR2M 35
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 8 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia POLR2M 35
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grinl1a 34
  • 52.49 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100003720 34
  • 49.35 (n)
POLR2M 35
  • 31 (a)
OneToOne
Species where no ortholog for POLR2M was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POLR2M Gene

ENSEMBL:
Gene Tree for POLR2M (if available)
TreeFam:
Gene Tree for POLR2M (if available)

Paralogs for POLR2M Gene

Paralogs for POLR2M Gene

(3) SIMAP similar genes for POLR2M Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for POLR2M Gene

genes like me logo Genes that share paralogs with POLR2M: view

Variants for POLR2M Gene

Sequence variations from dbSNP and Humsavar for POLR2M Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000469353 -- 57,707,671(+) GACCA(C/T)TAGCA intron-variant
rs1000542567 -- 57,707,498(+) AAAGA(C/T)GGTTT intron-variant
rs1000700173 -- 57,712,755(+) AGCAC(C/T)TTGTT intron-variant
rs1001026831 -- 57,713,008(+) CCAGC(A/G)TGGGC intron-variant
rs1001991878 -- 57,708,402(+) ATTGC(A/C)CTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR2M Gene

Variant ID Type Subtype PubMed ID
nsv1045611 CNV gain 25217958
nsv7266 OTHER inversion 18451855
nsv984076 CNV duplication 23825009

Variation tolerance for POLR2M Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR2M Gene

Human Gene Mutation Database (HGMD)
POLR2M
SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR2M

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2M Gene

Disorders for POLR2M Gene

Relevant External Links for POLR2M

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2M

No disorders were found for POLR2M Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR2M Gene

Publications for POLR2M Gene

  1. A Mediator-responsive form of metazoan RNA polymerase II. (PMID: 16769904) Hu X. … Gnatt A. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3 4 64
  2. Regulation of mammalian transcription by Gdown1 through a novel steric crosstalk revealed by cryo-EM. (PMID: 22850672) Wu Y.M. … Chang W.H. (EMBO J. 2012) 2 3 64
  3. Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A. (PMID: 20412299) Garcia-Mayoral M.F. … Bruix M. (FEBS J. 2010) 3 22 64
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for POLR2M Gene

Sources for POLR2M Gene

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