Aliases for POLR2M Gene
External Ids for POLR2M Gene
Previous HGNC Symbols for POLR2M Gene
Previous GeneCards Identifiers for POLR2M Gene
This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented with GeneID 145781. [provided by RefSeq, Oct 2013]
GeneCards Summary for POLR2M Gene
POLR2M (Polymerase (RNA) II (DNA Directed) Polypeptide M) is a Protein Coding gene. GO annotations related to this gene include DNA-directed RNA polymerase activity. An important paralog of this gene is GCOM1.
UniProtKB/Swiss-Prot for POLR2M Gene
Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.