Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

POLR2L Gene

protein-coding GIFtS: 61
GCID: GC11M000829

polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa

(Previous name: polymerase (RNA) II (DNA directed) polypeptide L (7.6kD)...)

Explore 60 diseases affiliated with
POLR2L via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Polymerase (RNA) II (DNA Directed) Polypeptide L, 7.6kDa¹ ²		RNA Polymerases I, II, And III Subunit ABC5² ³
RPB7.6¹ ² ³		RPB10 Homolog² ³
RBP10¹ ²		RPB10² ⁵
RPABC5¹ ²		HsRPB10b¹
RPB10beta¹ ²		Polymerase (RNA) II (DNA Directed) Polypeptide L (7.6kD)¹
HRPB7.6¹		DNA-Directed RNA Polymerases I, II, And III Subunit RPABC5²
DNA-Directed RNA Polymerase III Subunit L² ³		EC 2.7.7.6⁸
RNA Polymerase II 7.6 KDa Subunit² ³

External Ids:	HGNC: 9199¹	Entrez Gene: 5441²	Ensembl: ENSG00000177700⁷	OMIM: 601189⁵	UniProtKB: P62875³

Export aliases for POLR2L gene to outside databases

Previous GC identifers: GC11U990108 GC11P000668 GC11P000355 GC11M000831 GC11M000655

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POLR2L:

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in

eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding

domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RPAB5_HUMAN, P62875

Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside

triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA

precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs,

respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are

composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with

the central large cleft (By similarity)

Gene Wiki entry for POLR2L

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the POLR2L gene promoter:
MyoD AP-2gamma C/EBPalpha Egr-4 CHOP-10 HEN1 POU2F1 E2F POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: POLR2L promoter sequence

Search SABiosciences Chromatin IP Primers for POLR2L

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLR2L

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15

POLR2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR2L gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M000829: view genomic region (about GC identifiers)

Start:	837,356 bp from pter	End:	842,545 bp from pter
Size:	5,190 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RPAB5_HUMAN, P62875 (See protein sequence)

Recommended Name: DNA-directed RNA polymerases I, II, and III subunit RPABC5

Size: 67 amino acids; 7645 Da

Subunit: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III)

complexes consisting of at least 13, 12 and 17 subunits, respectively (By similarity)

Subcellular location: Nucleus

Secondary accessions: P52436 Q6FHX3

Explore the universe of human proteins at neXtProt for POLR2L: NX_P62875

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P62875

2 DME Specific Peptides for POLR2L (P62875)

RYCCRRM

PVRCFTCG

POLR2L Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_066951.1

ENSEMBL proteins:

ENSP00000432807 ENSP00000324124

Reactome Protein details: P62875
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: POLR2L OriGene Protein Over-expression Lysate: POLR2L OriGene Custom Protein Services for POLR2L
	GenScript Custom Purified and Recombinant Proteins Services for POLR2L
	Novus Biologicals POLR2L Protein Novus Biologicals POLR2L Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for POLR2L

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	9852112
GO:0005654	nucleoplasm	TAS	--
GO:0005665	DNA-directed RNA polymerase II, core complex	IDA	9852112

POLR2L for ontologies About GeneDecksing

POLR2L Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for POLR2L
	GenScript Custom Superior Antibodies Services for POLR2L
	Novus Biologicals POLR2L Antibody
	Search for Antibodies for POLR2L at Abcam
	Uscn Antibodies for POLR2L
	ThermoFisher Antibodies for POLR2L

Assay Products for POLR2L:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for POLR2L
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for POLR2L

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

POLR2L for domains About GeneDecksing

4 InterPro domains/families:

IPR000268 RNAP_N/Rpb10

IPR020789 RNA_pol_suN_Zn-BS

IPR009057 Homeodomain-like

IPR023580 RNA_pol_su_RPB10

Graphical View of Domain Structure for InterPro Entry P62875

ProtoNet protein and cluster: P62875

1 Blocks protein family: IPB000268 RNA polymerases N/8 Kd subunits

UniProtKB/Swiss-Prot: RPAB5_HUMAN, P62875

Similarity: Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RPAB5_HUMAN, P62875

Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside

triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA

precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs,

respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are

composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with

the central large cleft (By similarity)

Genatlas biochemistry entry for POLR2L:

polymerase II,RNA (DNA directed) small polypeptide L (7,6kDa),yeast RPB11 homolog

Enzyme Number (IUBMB): EC 2.7.7.6²

miRNA Products:		OriGene 3'-UTR Clone: POLR2L Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLR2L
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate POLR2L:
		hsa-miR-525-5p hsa-miR-520a-5p
		SwitchGear 3'UTR luciferase reporter plasmid: POLR2L 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLR2L (see all 7) OriGene shRNA RFP: POLR2L OriGene siRNA: POLR2L
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLR2L

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for POLR2L

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLR2L (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLR2L OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: POLR2L (NM_021128)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLR2L
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR2L

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for POLR2L
		Search LifeMap BioReagents cell lines for POLR2L

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for POLR2L

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003899	DNA-directed RNA polymerase activity	IEA	--
GO:0004672	contributes to protein kinase activity	IDA	9852112
GO:0008270	zinc ion binding	IEA	--

POLR2L for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for POLR2L:

Decreased influenza A H1N1 (A/	Decreased influenza A/WSN/33 r	Increased S DNA content	S arrest
Upregulation of Wnt/beta-caten

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Formation of RNA Pol II elongation complex

8/34 pathways (see all 34)
RNA Polymerase II Transcription Elongation	1.00	RNA Pol II CTD phosphorylation and interaction with CE	0.55
Formation of HIV-1 elongation complex in the absence of HIV-1 Tat	1.00	RNA Pol II CTD phosphorylation and interaction with CE	0.55
Formation of RNA Pol II elongation complex	1.00	Dual incision reaction in TC-NER	0.46
Formation of HIV-1 elongation complex containing HIV-1 Tat	0.98	Formation of transcription-coupled NER (TC-NER) repair complex	0.46

RNA Polymerase III Transcription Initiation

8/10 pathways (see all 10)
RNA Polymerase III Transcription Initiation	1.00	RNA Polymerase III Transcription Initiation From Type 2 Promoter	0.74
RNA Polymerase III Abortive And Retractive Initiation	1.00	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	0.59
RNA Polymerase III Transcription	1.00	RNA Polymerase III Chain Elongation	0.51
RNA Polymerase III Transcription Initiation From Type 3 Promoter	0.80	RNA Polymerase III Transcription Termination	0.51

mRNA Splicing - Major Pathway

mRNA Splicing	1.00	mRNA Processing	0.82
mRNA Splicing - Major Pathway	1.00	mRNA Splicing - Minor Pathway	0.40
Processing of Capped Intron-Containing Pre-mRNA	0.96

HIV Infection

	HIV Infection	1.00			Transcription Ligand-Dependent Transcription of Retinoid-Target genes	0.28
	Transcription_Ligand-Dependent Transcription of Retinoid-Target genes	0.28

Nucleotide Excision Repair

	Nucleotide Excision Repair	1.00			DNA Repair	0.46
	Transcription-coupled NER (TC-NER)	0.90

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for POLR2L

	Transcription Ligand-Dependent Transcription of Retinoid-Target genes
	DNA damage Role of Brca1 and Brca2 in DNA repair
	ATP/ITP metabolism

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POLR2L

	Assembly of RNA Polymerase-II Initiation Complex
	Transcription of mRNA

3 GeneGo (Thomson Reuters) Pathways for POLR2L

	DNA damage Role of Brca1 and Brca2 in DNA repair
	ATP/ITP metabolism
	Transcription Ligand-Dependent Transcription of Retinoid-Target genes

1 BioSystems Pathway for POLR2L

TNF-alpha/NF-kB Signaling Pathway

5/58 Reactome Pathways for POLR2L (see all 58)

	RNA Polymerase III Transcription Initiation
	Tat-mediated HIV-1 elongation arrest and recovery
	Tat-mediated elongation of the HIV-1 transcript
	mRNA Splicing
	RNA Polymerase III Chain Elongation

5/6 Kegg Pathways (Kegg details for POLR2L) (see all 6):

	Purine metabolism
	Pyrimidine metabolism
	Metabolic pathways
	RNA polymerase
	Cytosolic DNA-sensing pathway

POLR2L for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for POLR2L

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/279 Interacting proteins for POLR2L (P62875^{2, 3} ENSP00000324124⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 279)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
POLR2E	P19388²^,³, ENSP00000215587⁴	MINT-7264825 I2D: score=8 STRING: ENSP00000215587
CCDC85B	Q15834²^,³, ENSP00000311695⁴	MINT-67387 I2D: score=5 STRING: ENSP00000311695
POLR1B	Q9H9Y6²^,³, ENSP00000263331⁴	MINT-7264825 I2D: score=5 STRING: ENSP00000263331
POLR2H	P52434²^,³, ENSP00000296223⁴	MINT-7264825 I2D: score=4 STRING: ENSP00000296223
POLR1D	Q9Y2S0²^,³, ENSP00000302478⁴	MINT-7264825 I2D: score=3 STRING: ENSP00000302478

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000398	mRNA splicing, via spliceosome	TAS	--
GO:0006281	DNA repair	TAS	--
GO:0006283	transcription-coupled nucleotide-excision repair	TAS	--
GO:0006289	nucleotide-excision repair	TAS	--
GO:0006356	regulation of transcription from RNA polymerase I promoter	TAS	8786124

POLR2L for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

POLR2L for compounds About GeneDecksing

EMD Millipore small molecules for POLR2L:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for POLR2L
10/75 Novoseek chemical compound relationships for POLR2L gene (see all 75) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
s-napc	86.2	8	9732265 (2), 9003788 (1), 8633057 (1), 9644240 (1) (see all 7)
alpha-amanitin	86	44	15096519 (2), 1691987 (1), 1375332 (1), 9032404 (1) (see all 41)
5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole	84.4	35	7592583 (2), 10757782 (1), 10980390 (1), 12574128 (1) (see all 22)
flavopiridol	71.4	19	11431468 (3), 18000861 (2), 10906320 (1), 18509644 (1) (see all 9)
6-azauracil	70.3	1	9326634 (1)
5-bromo-utp	69.6	1	9880337 (1)
roscovitine	59.9	6	15692065 (1), 19938906 (1), 15851403 (1), 16275999 (1) (see all 6)
amatoxin	58.9	1	8061605 (1)
ctds	58	3	8497323 (1), 17028590 (1)
amanitin	57.5	2	8702941 (1), 8432390 (1)

Search CenterWatch for drugs/clinical trials and news about POLR2L / RPAB5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for POLR2L gene:

NM_021128.4

Unigene Cluster for POLR2L:

Polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa

Hs.441072 [show with all ESTs]

Unigene Representative Sequence: BM919305

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000534030 ENST00000322028(uc001lsc.3)

miRNA Products:		OriGene 3'-UTR Clone: POLR2L Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLR2L
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate POLR2L:
		hsa-miR-525-5p hsa-miR-520a-5p
		SwitchGear 3'UTR luciferase reporter plasmid: POLR2L 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLR2L (see all 7) OriGene shRNA RFP: POLR2L OriGene siRNA: POLR2L
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLR2L

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLR2L (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLR2L OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: POLR2L (NM_021128)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLR2L
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR2L

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLR2L Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat POLR2L
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR2L
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR2L

Additional cDNA sequence:

AJ420546.1 AK311997.1 BC005903.1 BC018649.2 CR536565.1 U37690.1

12 DOTS entries:

DT.448897 DT.100822667 DT.120756514 DT.101962328 DT.120756443 DT.120756501 DT.120756358 DT.120756531

DT.120756457 DT.102837666 DT.95215264 DT.100878646

24/239 AceView cDNA sequences (see all 239):

AA811986 AA101022 AA320057 AI281988 AA683555 BQ435190 AW964519 AW054871

BG254257 BF793297 BG741877 CR536565 AA304009 BC005903 BQ674363 CA309593

NM_021128 BU679804 AW950006 BU566060 AI497696 BG338847 CB136858 AI032424

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

POLR2L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCCTGAGC

About this image

POLR2L expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Ovary

Ovigerous Cord

Ovarian Somatic Cells

Ovary

Primitive Streak

Notochord

Primitive Streak

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

See POLR2L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POLR2L

SOURCE GeneReport for Unigene cluster: Hs.441072

SABiosciences Custom PCR Arrays for POLR2L

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLR2L Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat POLR2L
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR2L
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR2L

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for POLR2L

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2L gene from 9/33 species (see all 33) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Polr2l^{1 , 5}	polymerase (RNA) II (DNA directed) polypeptide L^{1, 5}	89.55(n)¹ 100(a)¹		7 (86.83 cM)⁵ 66491¹ NM_025593.1¹ NP_079869.1¹ 141471860⁵
chicken (Gallus gallus)	Aves	E1BSY6_CHICK⁶	Uncharacterized protein	100(a)	1 ↔ 1	5(16708738-16711093)
lizard (Anolis carolinensis)	Reptilia	POLR2L⁶	--	100(a)	1 ↔ 1	1(73484073-73493256)
African clawed frog (Xenopus laevis)	Amphibia	Xl.8250²	Xenopus laevis transcribed sequence with strong similarity more	78.16(n)		48013373
zebrafish (Danio rerio)	Actinopterygii	AL913334.1²	--	80.98(n)		AL913334.1
fruit fly (Drosophila melanogaster)	Insecta	Rpb10^{1 , 3}	transcription from Pol II promoter DNA-directed more³ CG13628-PA¹	92(a)³ 79.6(n)¹ 92.54(a)¹		96A18³ 42942¹ NM_143023.1¹ NP_651280.1¹
worm (Caenorhabditis elegans)	Secernentea	Y37E3.3³ rpb-10¹	Protein RPB-10¹	85(a)³ 73.63(n)¹ 85.07(a)¹		I(2064307-2064561)³ 171763¹ NM_058522.3¹ NP_490923.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	NRPB10¹	DNA-directed RNA Polymerase II subunit L	70.65(n) 80.6(a)		837690 NM_179309.2 NP_849640.1
rice (Oryza sativa)	Liliopsida	AK108801.1²	--	76.92(n)		AK108801.1

ENSEMBL Gene Tree for POLR2L (if available)
TreeFam Gene Tree for POLR2L (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for POLR2L gene

POLR2L for paralogs About GeneDecksing

5/6 Pseudogenes.org Pseudogenes for POLR2L (see all 6)
PGOHUM00000243579 PGOHUM00000245404 PGOHUM00000236884 PGOHUM00000243019 PGOHUM00000247369

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35044119^1,2	C,F,	--	657306(+)	`TCCAGG/ACTGGT`	1	--	us2k¹		4		NS NA	58
rs112416106^1,2	C	--	657758(+)	`CGCCTC/G/TACCCC`	1	--	us2k¹		1		CSA	1
rs111329635^1,2	C	--	657759(+)	`GCCTCA/C/TCCCCT`	1	--	us2k¹		1		CSA	1
rs34940311^1,2	C,F,H,	--	839369(+)	`GTAGAC/TCCTCA`	1	--	ds500¹		8		NS NA CSA WA	721
rs191024137^1,2		--	839463(+)	`GCACTG/TCCTGG`	1	--	ds500¹		0	--	--	--	--
rs151235689^1,2		--	839476(+)	`AGCAGC/GGCCTC`	1	--	ds500¹		0	--	--	--	--
rs35832719^1,2	C,F	--	839532(+)	`CCTCCC/TTGCTG`	1	--	ds500¹		5		NS NA CSA	93
rs28735718^1,2	C,F,	--	839629(+)	`CAGAAG/AATCTG`	1	--	ds500¹		12		NS NA WA CSA EA	457
rs182124145^1,2		--	839656(+)	`CATAGC/TTGTGT`	1	--	ds500¹		0	--	--	--	--
rs28692469^1,2	C,F,	--	839675(+)	`AGTCTC/TACTCT`	1	--	ds500¹		10		NA WA CSA EA	371

HapMap Linkage Disequilibrium report for POLR2L (837356 - 842545 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for POLR2L
6 CNVs: 29886 3831 29883 29885 31793 4726

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POLR2L

DNA2.0 Custom Variant and Variant Library Synthesis for POLR2L

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

POLR2L for disorders           About GeneDecksing

OMIM gene information: 601189    OMIM disorders: --

20/60 diseases for POLR2L (see all 60):    About MalaCards

congenital cataracts, facial dysmorphism, and neuropathy wiskott-aldrich syndrome xeroderma pigmentosum xeroderma pigmentosum, group b

human t-cell leukemia virus type 1 inclusion body myositis dna topoisomerase i renal clear cell carcinoma

cockayne syndrome anaplastic large cell lymphoma congenital cataracts myxoid liposarcoma

nonsyndromic deafness herpes simplex lupus erythematosus werner syndrome

liposarcoma mantle cell lymphoma systemic lupus erythematosus cataract

10/40 Novoseek disease relationships for POLR2L gene (see all 40) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cockayne syndrome	82.7	13	9880486 (1), 8811084 (1), 11182541 (1), 15226310 (1) (see all 12)
group b cockayne syndrome	80.3	5	9774388 (2), 9326587 (1), 17023424 (1), 17644494 (1)
xeroderma pigmentosum	68.4	7	1375332 (1), 9427533 (1), 11027286 (1), 8194528 (1) (see all 7)
group a cockayne syndrome	67.4	2	17981804 (1), 17283134 (1)
hepatitis delta	47	5	11387440 (1), 14506279 (1), 16959288 (1), 18552826 (1) (see all 5)
immunodeficiency	44.4	23	8876177 (2), 9311822 (1), 15254183 (1), 16131488 (1) (see all 22)
hrpt2	39.7	1	15923622 (1)
promyelocytic leukemia	26.6	2	16287851 (1), 16249232 (1)
ewings sarcoma	21.6	1	18677114 (1)
leukemia t-cell	19.4	2	9032404 (1), 8657153 (1)

Export disorders for POLR2L gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for POLR2L gene, integrated from 9 sources (see all 968):
(articles sorted by number of sources associating them with POLR2L)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PubMed id 9852112)^{1, 2} Kershnar E.... Chiang C.-M. (1998)
The gene (POLR2L) encoding the hRPB7.6 subunit of human RNA polymerase. (PubMed id 8786124)^{1, 3} Acker J....Vigneron M. (1996)
Six human RNA polymerase subunits functionally substitute for their yeast counterparts. (PubMed id 8524256)^{1, 2} McKune K.... Woychik N.A. (1995)
Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae. (PubMed id 7651387)^{1, 2} Shpakovski G.V....Vigneron M. (1995)
Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat. (PubMed id 7638159)^{1, 9} Wu-Baer F.... Gaynor R.B. (1995)
Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II. (PubMed id 8876177)^{1, 9} Okamoto H....Peterlin B.M. (1996)
Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription. (PubMed id 9184228)^{1, 9} Garcia-Martinez L.F....Gaynor R.B. (1997)
The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function. (PubMed id 8676484)^{1, 9} Yang X....Rice A.P. (1996)
Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor. (PubMed id 7853496)^{1, 9} Herrmann C.H. and Rice A.P. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5441	HGNC: 9199	AceView: POLR2L	Ensembl:ENSG00000177700	euGenes: HUgn5441
ECgene: POLR2L	Kegg: 5441	H-InvDB: POLR2L

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for POLR2L	Pharmacogenomics, SNPs, Pathways

Intellectual Property for POLR2L gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for POLR2L gene:
Search GeneIP for patents involving POLR2L

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Kits and Assays available from EMD Millipore
	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	EMD Millipore small molecules (inhibitor) for POLR2L
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for POLR2L
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLR2L		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLR2L
	OriGene Protein Over-expression Lysate for POLR2L		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for POLR2L		OriGene 3'-UTR Clone for POLR2L
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLR2L		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLR2L
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for POLR2L		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for POLR2L		OriGene Custom Protein Services for POLR2L
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POLR2L
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POLR2L
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLR2L
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLR2L
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR2L
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR2L

	GenScript Custom Purified and Recombinant Proteins Services for POLR2L		GenScript cDNA clones with any tag delivered in your preferred vector for POLR2L
	GenScript Custom Assay Services for POLR2L		GenScript Custom Superior Antibodies Services for POLR2L
	GenScript Custom overexpressing Cell Line Services for POLR2L		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in POLR2L promoter
	Search Chromatin IP Primers for POLR2L
	RT² qPCR Primer Assay in human, mouse / rat POLR2L
	Search GNC Networks for POLR2L
	SABiosciences PCR Arrays including human, mouse / rat POLR2L

Search Tocris compounds for POLR2L

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	POLR2L antibodies
	POLR2L proteins
	POLR2L lysates

	Search for Antibodies for POLR2L at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for POLR2L
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

POLR2L Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for POLR2L

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for POLR2L

	SwitchGear 3'UTR luciferase reporter plasmids for POLR2L
	SwitchGear Promoter luciferase reporter plasmids for POLR2L

ThermoFisher Antibodies for POLR2L

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR2L

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes POLR2L gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

POLR2L Gene

polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa

Aliases
for POLR2L gene

Summaries
for POLR2L gene

Genomic Views
for POLR2L gene

Proteins
for POLR2L gene

Protein Domains /
Families
for POLR2L gene

Function
for POLR2L gene

Pathways & Interactions
for POLR2L gene

Drugs & Compounds
for POLR2L gene

Transcripts
for POLR2L gene

Expression
for POLR2L gene

Orthologs
for POLR2L gene

Paralogs
for POLR2L gene

Genomic Variants
for POLR2L gene

Disorders / Diseases
for POLR2L gene

Publications
for POLR2L gene

External Searches for POLR2L gene

Genome Databases showing POLR2L gene

Other Databases showing POLR2L gene

Specialized Databases showing POLR2L gene

Intellectual Property
for POLR2L gene

Products
for POLR2L gene

View Random Gene

renal clear cell carcinoma
Wiskott-Aldrich Syndrome
Neurodegenerative Diseases
Leukemia T-Cell
Colon Cancer
promyelocytic leukemia
Retinoblastoma
HRPT2
Malaria
Herpes Simplex
Adenovirus Infections
Xeroderma Pigmentosum
Liposarcoma Myxoid
Congenital Cataract
Leukemia
Werner Syndrome
Alzheimers Disease
Breast Cancer
Hepatitis Delta
CMV INFECTION
HEPATOCELLULAR CARCINOMA
Cancer
Group A Cockayne Syndrome
Influenza
Poisoning
COLON ADENOCARCINOMA
Shock
Group B Cockayne Syndrome
Ewings sarcoma
immunodeficiency
Cardiac Hypertrophy
Hepatitis B
prostate cancer
Cockayne Syndrome
Tumors
Autoimmunity
Necrosis
Sclerosis Systemic
virus infection
Lupus Erythematosus Systemic

Advanced Search

Export list of displayed genes

POLR2L Gene

polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa

Aliasesfor POLR2L gene

Summariesfor POLR2L gene

Genomic Viewsfor POLR2L gene

Proteinsfor POLR2L gene

Protein Domains /Familiesfor POLR2L gene

Functionfor POLR2L gene

Pathways & Interactionsfor POLR2L gene

Drugs & Compoundsfor POLR2L gene

Transcriptsfor POLR2L gene

Expression for POLR2L gene

Orthologsfor POLR2L gene

Paralogsfor POLR2L gene

Genomic Variantsfor POLR2L gene

Disorders / Diseasesfor POLR2L gene

Publicationsfor POLR2L gene

External Searches for POLR2L gene

Genome Databases showing POLR2L gene

Other Databases showing POLR2L gene

Specialized Databases showing POLR2L gene

Intellectual Propertyfor POLR2L gene

Productsfor POLR2L gene

View Random Gene

Aliases
for POLR2L gene

Summaries
for POLR2L gene

Genomic Views
for POLR2L gene

Proteins
for POLR2L gene

Protein Domains /
Families
for POLR2L gene

Function
for POLR2L gene

Pathways & Interactions
for POLR2L gene

Drugs & Compounds
for POLR2L gene

Transcripts
for POLR2L gene

Expression
for POLR2L gene

Orthologs
for POLR2L gene

Paralogs
for POLR2L gene

Genomic Variants
for POLR2L gene

Disorders / Diseases
for POLR2L gene

Publications
for POLR2L gene

Intellectual Property
for POLR2L gene

Products
for POLR2L gene