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POLR2L Gene

protein-coding   GIFtS: 62
GCID: GC11M000829

Polymerase (RNA) II (DNA Directed) Polypeptide L, 7.6kDa

(Previous name: polymerase (RNA) II (DNA directed) polypeptide L (7.6kD))
  See POLR2L-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Polymerase (RNA) II (DNA Directed) Polypeptide L, 7.6kDa1 2     Polymerase (RNA) II (DNA Directed) Polypeptide L (7.6kD)1
RPB7.62 3     RBP102
DNA-Directed RNA Polymerase III Subunit L2 3     RPABC52
RNA Polymerase II 7.6 KDa Subunit2 3     RPB10beta2
RNA Polymerases I, II, And III Subunit ABC52 3     DNA-Directed RNA Polymerases I, II, And III Subunit RPABC52
RPB10 Homolog2 3     hRPB7.62
RPB102 5     EC 2.7.7.68

External Ids:    HGNC: 91991   Entrez Gene: 54412   Ensembl: ENSG000001777007   OMIM: 6011895   UniProtKB: P628753   

Export aliases for POLR2L gene to outside databases

Previous GC identifers: GC11U990108 GC11P000668 GC11P000355 GC11M000831 GC11M000655


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POLR2L Gene:
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in
eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding
domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases.
(provided by RefSeq, Jul 2008)

GeneCards Summary for POLR2L Gene:
POLR2L (polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa) is a protein-coding gene. Diseases associated with POLR2L include malaria. GO annotations related to this gene include DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot: RPAB5_HUMAN, P62875
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA
precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs,
respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are
composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element
with the central large cleft (By similarity)

Gene Wiki entry for POLR2L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the POLR2L gene promoter:
         MyoD   AP-2gamma   C/EBPalpha   Egr-4   CHOP-10   HEN1   POU2F1   E2F   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOLR2L promoter sequence
   Search Chromatin IP Primers for POLR2L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POLR2L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15

POLR2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR2L gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M000829:  view genomic region     (about GC identifiers)

Start:
837,356 bp from pter      End:
842,545 bp from pter
Size:
5,190 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RPAB5_HUMAN, P62875 (See protein sequence)
Recommended Name: DNA-directed RNA polymerases I, II, and III subunit RPABC5  
Size: 67 amino acids; 7645 Da
Subunit: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III)
complexes consisting of at least 13, 12 and 17 subunits, respectively (By similarity)
Secondary accessions: P52436 Q6FHX3

Explore the universe of human proteins at neXtProt for POLR2L: NX_P62875

Explore proteomics data for POLR2L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys17, Lys41
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for POLR2L (P62875)
     RYCCRRM  PVRCFTCG 


    See POLR2L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066951.1  
    ENSEMBL proteins: 
     ENSP00000432807   ENSP00000324124  
    Reactome Protein details: P62875

    POLR2L Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for POLR2L

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POLR: RNA polymerase subunits

    4 InterPro protein domains:
     IPR000268 RNAP_N/Rpb10
     IPR020789 RNA_pol_suN_Zn-BS
     IPR009057 Homeodomain-like
     IPR023580 RNA_pol_su_RPB10

    Graphical View of Domain Structure for InterPro Entry P62875

    ProtoNet protein and cluster: P62875

    1 Blocks protein domain: IPB000268 RNA polymerases N/8 Kd subunits

    UniProtKB/Swiss-Prot: RPAB5_HUMAN, P62875
    Similarity: Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family


    Find genes that share domains with POLR2L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPAB5_HUMAN, P62875
    Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
    triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA
    precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs,
    respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are
    composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element
    with the central large cleft (By similarity)

         Genatlas biochemistry entry for POLR2L:
    polymerase II,RNA (DNA directed) small polypeptide L (7,6kDa),yeast RPB11 homolog

         Enzyme Number (IUBMB): EC 2.7.7.62

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001054contributes to RNA polymerase I activity IBA--
    GO:0001055contributes to RNA polymerase II activity IBA--
    GO:0001056contributes to RNA polymerase III activity IBA--
    GO:0003677DNA binding IEA--
    GO:0003899DNA-directed RNA polymerase activity TAS8524256
         
    Find genes that share ontologies with POLR2L           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for POLR2L:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased S DNA content  S arrest 
     Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POLR2L
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POLR2L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POLR2L

    miRNA
    Products:
        
    miRTarBase miRNAs that target POLR2L:
    hsa-mir-92a-3p (MIRT049695), hsa-mir-744-5p (MIRT037575), hsa-mir-423-3p (MIRT042647), hsa-let-7b-5p (MIRT032392), hsa-mir-331-3p (MIRT043387), hsa-mir-124-3p (MIRT022925)

    Block miRNA regulation of human, mouse, rat POLR2L using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate POLR2L:
    hsa-miR-525-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidPOLR2L 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RPAB5_HUMAN, P62875: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9852112
    GO:0005654nucleoplasm TAS--
    GO:0005665DNA-directed RNA polymerase II, core complex IDA9852112
    GO:0005666DNA-directed RNA polymerase III complex IBA--
    GO:0005736DNA-directed RNA polymerase I complex IBA--

    Find genes that share ontologies with POLR2L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POLR2L About   (see all 19)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1RNA Polymerase III Transcription Initiation
    RNA Polymerase III Transcription Initiation0.88
    RNA Polymerase III Transcription Initiation From Type 2 Promoter0.74
    RNA Polymerase III Abortive And Retractive Initiation0.88
    RNA Polymerase III Transcription Termination0.58
    RNA Polymerase III Transcription0.88
    RNA polymerase0.45
    RNA Polymerase III Transcription Initiation From Type 3 Promoter0.80
    RNA Polymerase III Chain Elongation0.00
    2Purine metabolism (KEGG)
    Purine metabolism0.38
    ATP ITP metabolism0.31
    Pyrimidine metabolism0.38
    3Cytosolic sensors of pathogen-associated DNA
    Cytosolic sensors of pathogen-associated DNA0.38
    Cytosolic DNA-sensing pathway0.33
    4Formation of RNA Pol II elongation complex
    mRNA Capping0.93
    HIV elongation arrest and recovery0.73
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Pausing and recovery of Tat-mediated HIV elongation0.72
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Tat-mediated HIV elongation arrest and recovery0.72
    Formation of the Early Elongation Complex0.77
    Transcription of the HIV genome0.71
    5DNA Repair
    Transcription-coupled NER (TC-NER)0.90
    Formation of transcription-coupled NER (TC-NER) repair complex0.65
    Nucleotide Excision Repair0.90
    DNA Repair0.45
    Dual incision reaction in TC-NER0.65


    Find genes that share SuperPaths with POLR2L           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for POLR2L
        Assembly of RNA Polymerase-II Initiation Complex
    Transcription of mRNA

    3 GeneGo (Thomson Reuters) Pathways for POLR2L
        DNA damage Role of Brca1 and Brca2 in DNA repair
    ATP/ITP metabolism
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for POLR2L
        TNF-alpha/NF-kB Signaling Pathway

    Selected Reactome Pathways for POLR2L (see all 38)
        Tat-mediated HIV elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    RNA Polymerase III Chain Elongation
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    RNA Polymerase III Transcription Initiation From Type 1 Promoter


    Selected Kegg Pathways  (Kegg details for POLR2L) (see all 7):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways
    RNA polymerase
    Cytosolic DNA-sensing pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POLR2L
    Interactions:

        Search GeneGlobe Interaction Network for POLR2L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for POLR2L (P628752, 3 ENSP000003241244) via UniProtKB, MINT, STRING, and/or I2D (see all 335)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR1AO956022, 3, ENSP000002638574MINT-7264825 I2D: score=6 STRING: ENSP00000263857
    CCDC85BQ158342, 3, ENSP000003116954MINT-67387 I2D: score=5 STRING: ENSP00000311695
    POLR1BQ9H9Y62, 3, ENSP000002633314MINT-7264825 I2D: score=5 STRING: ENSP00000263331
    POLR2HP524342, 3, ENSP000002962234MINT-7264825 I2D: score=4 STRING: ENSP00000296223
    NFKBIBQ156532, 3MINT-47870 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006281DNA repair TAS--
    GO:0006283transcription-coupled nucleotide-excision repair TAS--
    GO:0006289nucleotide-excision repair TAS--
    GO:0006351transcription, DNA-templated ----

    Find genes that share ontologies with POLR2L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POLR2L (RPAB5)

    Selected Novoseek inferred chemical compound relationships for POLR2L gene (see all 75)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-napc 86.2 8 9732265 (2), 9003788 (1), 8633057 (1), 9644240 (1) (see all 7)
    alpha-amanitin 86 44 15096519 (2), 1691987 (1), 1375332 (1), 9032404 (1) (see all 41)
    5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole 84.4 35 7592583 (2), 10757782 (1), 10980390 (1), 12574128 (1) (see all 22)
    flavopiridol 71.4 19 11431468 (3), 18000861 (2), 10906320 (1), 18509644 (1) (see all 9)
    6-azauracil 70.3 1 9326634 (1)
    5-bromo-utp 69.6 1 9880337 (1)
    roscovitine 59.9 6 15692065 (1), 19938906 (1), 15851403 (1), 16275999 (1) (see all 6)
    amatoxin 58.9 1 8061605 (1)
    ctds 58 3 8497323 (1), 17028590 (1)
    amanitin 57.5 2 8702941 (1), 8432390 (1)



    Find genes that share compounds with POLR2L           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for POLR2L gene: 
    NM_021128.4  

    Unigene Cluster for POLR2L:

    Polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
    Hs.441072  [show with all ESTs]
    Unigene Representative Sequence: BM919305
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534030 ENST00000322028(uc001lsc.3)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate POLR2L:
    hsa-miR-525-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidPOLR2L 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: POLR2L (NM_021128)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLR2L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR2L
    Primer
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    OriGene qPCR primer pairs and template standards for POLR2L
    OriGene qSTAR qPCR primer pairs in human, mouse for POLR2L
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat POLR2L
      QuantiTect SYBR Green Assays in human, mouse, rat POLR2L
      QuantiFast Probe-based Assays in human, mouse, rat POLR2L

    Additional mRNA sequence: 

    AJ420546.1 AK311997.1 BC005903.1 BC018649.2 CR536565.1 U37690.1 

    12 DOTS entries:

    DT.448897  DT.100822667  DT.120756514  DT.101962328  DT.120756443  DT.120756501  DT.120756358  DT.120756531 
    DT.120756457  DT.102837666  DT.95215264  DT.100878646 

    Selected AceView cDNA sequences (see all 239):

    BQ435190 AW964519 AA683555 AA101022 AA320057 AI281988 AA811986 AI497696 
    CK905258 AI718610 BG255797 BQ219112 AA304009 BG747452 CB136858 AA429820 
    BF793297 BF345021 AI032424 AW950006 BE855791 CR536565 AA625381 CB108435 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    POLR2L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCTGAGC
    POLR2L Expression
    About this image


    POLR2L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
             Nucleus Pulposus
     
     Lung (Respiratory System)
             Stem Bronchi
     
     Primitive Streak (Early Embryonic Tissues)
             Notochord
    POLR2L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POLR2L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.441072
        Custom PCR Arrays for POLR2L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for POLR2L gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Polr2l1 , 5 polymerase (RNA) II (DNA directed) polypeptide L1, 5 89.55(n)1
    100(a)1
      7 (86.83 cM)5
    664911  NM_025593.11  NP_079869.11 
     1414718605 
    chicken
    (Gallus gallus)
    Aves POLR2L1 polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 82.59(n)
    100(a)
      770704  XM_001233058.3  XP_001233059.3 
    lizard
    (Anolis carolinensis)
    Reptilia POLR2L6
    polymerase (RNA) II (DNA directed) polypeptide L, ...
    100(a)
    1 ↔ 1
    1(73484073-73493256)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.82502 Xenopus laevis transcribed sequence with strong similarity more 78.16(n)    48013373 
    zebrafish
    (Danio rerio)
    Actinopterygii AL913334.12   -- 80.98(n)    AL913334.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rpb101 , 3 transcription from Pol II promoter
    DNA-directed more3
    Rpb101
    92(a)3
    79.6(n)1
    92.54(a)1
      96A183
    429421  NM_143023.11  NP_651280.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y37E3.33
    rpb-101
    rpb-101 85(a)3
    73.63(n)1
    85.07(a)1
      I(2064307-2064561)3
    1717631  NM_058522.41  NP_490923.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPB10(YOR210W)4
    RPB101
    RNA polymerase subunit ABC10-beta, common to RNA polymerases more4
    RPB101
    58.21(n)1
    74.63(a)1
      15(738320-738532)4
    8543851, 4  NP_014853.31  NP_014853.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NRPB101 NRPB10 70.65(n)
    80.6(a)
      837690  NM_179309.2  NP_849640.1 
    rice
    (Oryza sativa)
    Liliopsida AK108801.12   -- 76.92(n)    AK108801.1 


    ENSEMBL Gene Tree for POLR2L (if available)
    TreeFam Gene Tree for POLR2L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for POLR2L gene

    Find genes that share paralogs with POLR2L           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for POLR2L (see all 6)
    PGOHUM00000243579 PGOHUM00000245404 PGOHUM00000236884 PGOHUM00000243019 PGOHUM00000247369


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POLR2L (see all 82)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs349403111,2
    C,F,H--839369(+) GTAGAC/TCCTCA 1 -- ds50018Minor allele frequency- T:0.01NS NA CSA WA 721
    rs1910241371,2
    --839463(+) GCACTG/TCCTGG 1 -- ds50010--------
    rs1512356891,2
    --839476(+) AGCAGC/GGCCTC 1 -- ds50010--------
    rs358327191,2
    C,F--839532(+) CCTCCC/TTGCTG 1 -- ds50015Minor allele frequency- T:0.02NS NA CSA 93
    rs287357181,2
    C,F--839629(+) CAGAAG/AATCTG 1 -- ds500112Minor allele frequency- A:0.30NS NA WA CSA EA 457
    rs1821241451,2
    --839656(+) CATAGC/TTGTGT 1 -- ds50010--------
    rs286924691,2
    C,F--839675(+) AGTCTC/TACTCT 1 -- ds500110Minor allele frequency- T:0.31NA WA CSA EA 371
    rs1868153441,2
    --839706(+) GTGGTA/GCAAAC 1 -- ds50010--------
    rs340388051,2
    C,F--839755(+) TCCTCC/TTGCCT 1 -- ut315Minor allele frequency- T:0.06NS NA WA 214
    rs1999506101,2
    --839763(+) CTCAG-/CCCCCCG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for POLR2L (837356 - 842545 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for POLR2L (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv182e199CNV Deletion23128226
    nsv832044CNV Loss17160897
    dgv952n71CNV Loss21882294
    nsv469923CNV Loss18288195
    dgv956n71CNV Loss21882294
    dgv946n71CNV Loss21882294
    nsv896636CNV Loss21882294
    dgv944n71CNV Loss21882294
    nsv896631CNV Loss21882294
    dgv955n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POLR2L
    DNA2.0 Custom Variant and Variant Library Synthesis for POLR2L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601189    OMIM disorders: --

    1 disease for POLR2L:    
    About MalaCards
    malaria


    Find genes that share disorders with POLR2L           About GenesLikeMe

    Selected Novoseek inferred disease relationships for POLR2L gene (see all 40)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cockayne syndrome 82.7 13 9880486 (1), 8811084 (1), 11182541 (1), 15226310 (1) (see all 12)
    group b cockayne syndrome 80.3 5 9774388 (2), 9326587 (1), 17023424 (1), 17644494 (1)
    xeroderma pigmentosum 68.4 7 1375332 (1), 9427533 (1), 11027286 (1), 8194528 (1) (see all 7)
    group a cockayne syndrome 67.4 2 17981804 (1), 17283134 (1)
    hepatitis delta 47 5 11387440 (1), 14506279 (1), 16959288 (1), 18552826 (1) (see all 5)
    immunodeficiency 44.4 23 8876177 (2), 9311822 (1), 15254183 (1), 16131488 (1) (see all 22)
    hrpt2 39.7 1 15923622 (1)
    promyelocytic leukemia 26.6 2 16287851 (1), 16249232 (1)
    ewings sarcoma 21.6 1 18677114 (1)
    leukemia t-cell 19.4 2 9032404 (1), 8657153 (1)


    Export disorders for POLR2L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POLR2L gene, integrated from 10 sources (see all 972):
    (articles sorted by number of sources associating them with POLR2L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PubMed id 9852112)1, 2 Kershnar E.... Chiang C.-M. (J. Biol. Chem. 1998)
    3. The gene (POLR2L) encoding the hRPB7.6 subunit of human RNA polymerase. (PubMed id 8786124)1, 3 Acker J....Vigneron M. (Genomics 1996)
    4. Six human RNA polymerase subunits functionally substitute for their yeast counterparts. (PubMed id 8524256)1, 2 McKune K.... Woychik N.A. (Mol. Cell. Biol. 1995)
    5. Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae. (PubMed id 7651387)1, 2 Shpakovski G.V....Vigneron M. (Mol. Cell. Biol. 1995)
    6. Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat. (PubMed id 7638159)1, 9 Wu-Baer F.... Gaynor R.B. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    7. Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II. (PubMed id 8876177)1, 9 Okamoto H....Peterlin B.M. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    8. Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription. (PubMed id 9184228)1, 9 GarcA-a-MartA-nez L.F....Gaynor R.B. (EMBO J. 1997)
    9. The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function. (PubMed id 8676484)1, 9 Yang X....Rice A.P. (J. Virol. 1996)
    10. Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor. (PubMed id 7853496)1, 9 Herrmann C.H. and Rice A.P. (J. Virol. 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5441 HGNC: 9199 AceView: POLR2L Ensembl:ENSG00000177700 euGenes: HUgn5441
    ECgene: POLR2L Kegg: 5441 H-InvDB: POLR2L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for POLR2L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for POLR2L gene:
    Search GeneIP for patents involving POLR2L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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