Free for academic non-profit institutions. Other users need a Commercial license

Aliases for POLR2L Gene

Aliases for POLR2L Gene

  • Polymerase (RNA) II Subunit L 2 3
  • Polymerase (RNA) II (DNA Directed) Polypeptide L, 7.6kDa 2 3 5
  • RNA Polymerases I, II, And III Subunit ABC5 3 4
  • DNA-Directed RNA Polymerase III Subunit L 3 4
  • RNA Polymerase II 7.6 KDa Subunit 3 4
  • RPB10 Homolog 3 4
  • RPB7.6 3 4
  • EC 2.7.7.6 63
  • RPB10beta 3
  • HRPB7.6 3
  • RPABC5 3
  • RBP10 3
  • RPB10 3

External Ids for POLR2L Gene

Previous GeneCards Identifiers for POLR2L Gene

  • GC11U990108
  • GC11P000668
  • GC11P000355
  • GC11M000831
  • GC11M000655

Summaries for POLR2L Gene

Entrez Gene Summary for POLR2L Gene

  • This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2L Gene

POLR2L (Polymerase (RNA) II Subunit L) is a Protein Coding gene. Diseases associated with POLR2L include hyperparathyroidism-jaw tumor syndrome and pharyngoconjunctival fever. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Epstein-Barr virus infection. GO annotations related to this gene include DNA-directed RNA polymerase activity and RNA polymerase I activity.

UniProtKB/Swiss-Prot for POLR2L Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity).

Gene Wiki entry for POLR2L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2L Gene

Genomics for POLR2L Gene

Regulatory Elements for POLR2L Gene

Enhancers for POLR2L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POLR2L on UCSC Golden Path with GeneCards custom track

Promoters for POLR2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POLR2L on UCSC Golden Path with GeneCards custom track

Genomic Location for POLR2L Gene

Chromosome:
11
Start:
837,356 bp from pter
End:
842,545 bp from pter
Size:
5,190 bases
Orientation:
Minus strand

Genomic View for POLR2L Gene

Genes around POLR2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2L Gene

Proteins for POLR2L Gene

  • Protein details for POLR2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62875-RPAB5_HUMAN
    Recommended name:
    DNA-directed RNA polymerases I, II, and III subunit RPABC5
    Protein Accession:
    P62875
    Secondary Accessions:
    • P52436
    • Q6FHX3

    Protein attributes for POLR2L Gene

    Size:
    67 amino acids
    Molecular mass:
    7645 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.

neXtProt entry for POLR2L Gene

Proteomics data for POLR2L Gene at MOPED

Selected DME Specific Peptides for POLR2L Gene

Post-translational modifications for POLR2L Gene

  • Ubiquitination at Lys 41
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR2L Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for POLR2L Gene

Gene Families for POLR2L Gene

Protein Domains for POLR2L Gene

Suggested Antigen Peptide Sequences for POLR2L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62875

UniProtKB/Swiss-Prot:

RPAB5_HUMAN :
  • Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family.
Family:
  • Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2L: view

Function for POLR2L Gene

Molecular function for POLR2L Gene

GENATLAS Biochemistry:
polymerase II,RNA (DNA directed) small polypeptide L (7,6kDa),yeast RPB11 homolog
UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity).

Enzyme Numbers (IUBMB) for POLR2L Gene

Gene Ontology (GO) - Molecular Function for POLR2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001054 contributes_to RNA polymerase I activity IBA --
genes like me logo Genes that share ontologies with POLR2L: view
genes like me logo Genes that share phenotypes with POLR2L: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2L Gene

Localization for POLR2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR2L Gene COMPARTMENTS Subcellular localization image for POLR2L gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 2

Gene Ontology (GO) - Cellular Components for POLR2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR2L: view

Pathways & Interactions for POLR2L Gene

SuperPathways for POLR2L Gene

Superpath Contained pathways
1 Formation of the HIV-1 Early Elongation Complex
2 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
3 RNA Polymerase II Transcription Initiation And Promoter Clearance
4 RNA Polymerase III Transcription Initiation
5 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
genes like me logo Genes that share pathways with POLR2L: view

Gene Ontology (GO) - Biological Process for POLR2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006356 regulation of transcription from RNA polymerase I promoter TAS 8786124
genes like me logo Genes that share ontologies with POLR2L: view

No data available for SIGNOR curated interactions for POLR2L Gene

Drugs & Compounds for POLR2L Gene

(41) Drugs for POLR2L Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0

(39) Additional Compounds for POLR2L Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with POLR2L: view

Transcripts for POLR2L Gene

mRNA/cDNA for POLR2L Gene

Unigene Clusters for POLR2L Gene

Polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2L Gene

No ASD Table

Relevant External Links for POLR2L Gene

GeneLoc Exon Structure for
POLR2L
ECgene alternative splicing isoforms for
POLR2L

Expression for POLR2L Gene

mRNA expression in normal human tissues for POLR2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR2L Gene

This gene is overexpressed in Pancreas (17.2) and Tlymphocyte (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLR2L Gene



SOURCE GeneReport for Unigene cluster for POLR2L Gene Hs.441072

genes like me logo Genes that share expression patterns with POLR2L: view

Protein tissue co-expression partners for POLR2L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLR2L Gene

Orthologs for POLR2L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POLR2L 35
  • 94.03 (n)
  • 100 (a)
POLR2L 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr2l 35
  • 89.55 (n)
  • 100 (a)
Polr2l 16
Gm10774 36
  • 99 (a)
OneToMany
Polr2l 36
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia POLR2L 35
  • 100 (n)
  • 100 (a)
POLR2L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911840 35
  • 88.06 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves POLR2L 35
  • 82.59 (n)
  • 100 (a)
POLR2L 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLR2L 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2l.1 35
  • 78.61 (n)
  • 100 (a)
Str.6602 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8250 35
zebrafish
(Danio rerio)
Actinopterygii polr2l 35
  • 80.1 (n)
  • 98.51 (a)
polr2l 36
  • 99 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rpb10 37
  • 92 (a)
Rpb10 35
  • 79.6 (n)
  • 92.54 (a)
Rpb10 36
  • 93 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011761 35
  • 81.09 (n)
  • 95.52 (a)
worm
(Caenorhabditis elegans)
Secernentea Y37E3.3 37
  • 85 (a)
rpb-10 35
  • 73.63 (n)
  • 85.07 (a)
rpb-10 36
  • 85 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR163W 35
  • 68.66 (n)
  • 74.63 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D06699g 35
  • 58.71 (n)
  • 74.63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB10 35
  • 58.21 (n)
  • 74.63 (a)
RPB10 36
  • 71 (a)
OneToOne
RPB10 38
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPB10 35
  • 70.65 (n)
  • 80.6 (a)
rice
(Oryza sativa)
Liliopsida Os11g0194800 35
  • 77.61 (n)
  • 83.58 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.6936 35
corn
(Zea mays)
Liliopsida Zm.7018 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3728 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02605 35
  • 73.96 (n)
  • 71.87 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb10 35
  • 65.67 (n)
  • 71.64 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4791 36
  • 90 (a)
OneToOne
Species with no ortholog for POLR2L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for POLR2L Gene

ENSEMBL:
Gene Tree for POLR2L (if available)
TreeFam:
Gene Tree for POLR2L (if available)

Paralogs for POLR2L Gene

genes like me logo Genes that share paralogs with POLR2L: view

No data available for Paralogs for POLR2L Gene

Variants for POLR2L Gene

Sequence variations from dbSNP and Humsavar for POLR2L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1130324 -- 840,351(-) CCCAC(A/C/T)CGCTG utr-variant-3-prime
rs11556453 -- 840,465(-) GATGC(C/T)CTGGG reference, synonymous-codon
rs112247591 -- 840,202(+) ACCTT(A/T)GTGGT utr-variant-3-prime
rs112456898 -- 840,268(+) ACTGC(-/TGT)GGCCA utr-variant-3-prime
rs67833265 -- 839,768(+) CCCCG(-/CT)AGTGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for POLR2L Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV Deletion 23128226
dgv921n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
essv23843 CNV CNV 17122850
dgv936n71 CNV Loss 21882294
dgv944n71 CNV Loss 21882294
dgv945n71 CNV Loss 21882294
dgv946n71 CNV Loss 21882294
essv11734 CNV CNV 17122850
dgv947n71 CNV Loss 21882294
nsv896599 CNV Loss 21882294
nsv832044 CNV Loss 17160897
dgv950n71 CNV Gain 21882294
nsv896608 CNV Loss 21882294
dgv952n71 CNV Loss 21882294
dgv954n71 CNV Gain 21882294
nsv896619 CNV Gain 21882294
dgv955n71 CNV Loss 21882294
nsv896630 CNV Loss 21882294
nsv896631 CNV Loss 21882294
nsv896632 CNV Gain 21882294
nsv896633 CNV Loss 21882294
dgv956n71 CNV Loss 21882294
nsv8760 CNV Loss 18304495
nsv896636 CNV Loss 21882294

Variation tolerance for POLR2L Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR2L Gene

HapMap Linkage Disequilibrium report
POLR2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2L Gene

Disorders for POLR2L Gene

MalaCards: The human disease database

(2) MalaCards diseases for POLR2L Gene - From: Novoseek

Disorder Aliases PubMed IDs
hyperparathyroidism-jaw tumor syndrome
  • parathyroid adenoma with cystic changes
pharyngoconjunctival fever
  • adenoviral pharyngoconjunctivitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POLR2L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2L
genes like me logo Genes that share disorders with POLR2L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR2L Gene

Publications for POLR2L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The HIV-1 Tat team gets bigger. (PMID: 20227660) Rice A.P. (Cell Host Microbe 2010) 3 23
  3. Domains in the SPT5 protein that modulate its transcriptional regulatory properties. (PMID: 10757782) Ivanov D. … Gaynor R.B. (Mol. Cell. Biol. 2000) 3 23
  4. The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat. (PMID: 9696809) Fujinaga K. … Peterlin B.M. (J. Virol. 1998) 3 23
  5. Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II. (PMID: 8876177) Okamoto H. … Peterlin B.M. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 23

Products for POLR2L Gene

Sources for POLR2L Gene

Content