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Aliases for POLR2L Gene

Aliases for POLR2L Gene

  • RNA Polymerase II Subunit L 2 3 5
  • Polymerase (RNA) II (DNA Directed) Polypeptide L, 7.6kDa 2 3
  • RNA Polymerases I, II, And III Subunit ABC5 3 4
  • DNA-Directed RNA Polymerase III Subunit L 3 4
  • RNA Polymerase II 7.6 KDa Subunit 3 4
  • RPB10 Homolog 3 4
  • RPB7.6 3 4
  • DNA-Directed RNA Polymerases I, II, And III Subunit RPABC5 3
  • Polymerase (RNA) II Subunit L 3
  • EC 2.7.7.6 61
  • RPB10beta 3
  • HRPB7.6 3
  • RPABC5 3
  • RBP10 3
  • RPB10 3

External Ids for POLR2L Gene

Previous GeneCards Identifiers for POLR2L Gene

  • GC11U990108
  • GC11P000668
  • GC11P000355
  • GC11M000831
  • GC11M000655

Summaries for POLR2L Gene

Entrez Gene Summary for POLR2L Gene

  • This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2L Gene

POLR2L (RNA Polymerase II Subunit L) is a Protein Coding gene. Diseases associated with POLR2L include Cockayne Syndrome and Hyperparathyroidism-Jaw Tumor Syndrome. Among its related pathways are Immune System and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include DNA-directed RNA polymerase activity and RNA polymerase I activity.

UniProtKB/Swiss-Prot for POLR2L Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity).

Gene Wiki entry for POLR2L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2L Gene

Genomics for POLR2L Gene

Regulatory Elements for POLR2L Gene

Enhancers for POLR2L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F000969 0.6 ENCODE 6.5 -127.7 -127709 1.4 AP2A2 RNU6-1025P CHID1 LOC101927503 POLR2L KRTAP5-AS1 GC11P000968 GC11M000999
GH11F000839 1.1 ENCODE 6.1 -1.2 -1236 7.6 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 CD151 TSPAN4 RPLP2 PIDD1 SNORA52 SLC25A22 AP2A2 CEND1 ENSG00000255237 POLR2L
GH11F000951 0.8 Ensembl ENCODE 6.1 -113.0 -113015 8.4 HDGF PKNOX1 MLX ARID4B SIN3A ZNF48 YY1 SLC30A9 ZNF121 NFYC DRD4 ENSG00000255142 ENSG00000255158 LOC101927503 POLR2L AP2A2 LOC171391 RNU6-1025P GC11P000968
GH11F000930 0.7 Ensembl ENCODE 5.8 -92.1 -92122 8.1 PKNOX1 ARID4B RAD21 YY1 SCRT2 FOS EGR2 CEBPB NR2F2 NFIL3 LOC101927503 POLR2L AP2A2 IRF7 LRRC56 GC11M000925 GC11P000950
GH11F000939 1.1 Ensembl ENCODE 5.7 -99.1 -99085 4.3 ELF3 NFRKB ARID4B ZSCAN9 RARA ZNF121 SCRT2 CREM REST PPARG AP2A2 POLR2L IRF7 LOC171391 GC11P000950 GC11M000925
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around POLR2L on UCSC Golden Path with GeneCards custom track

Promoters for POLR2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001567561 -755 3401 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 ZNF207

Genomic Location for POLR2L Gene

Chromosome:
11
Start:
837,356 bp from pter
End:
842,545 bp from pter
Size:
5,190 bases
Orientation:
Minus strand

Genomic View for POLR2L Gene

Genes around POLR2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2L Gene

Proteins for POLR2L Gene

  • Protein details for POLR2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62875-RPAB5_HUMAN
    Recommended name:
    DNA-directed RNA polymerases I, II, and III subunit RPABC5
    Protein Accession:
    P62875
    Secondary Accessions:
    • P52436
    • Q6FHX3

    Protein attributes for POLR2L Gene

    Size:
    67 amino acids
    Molecular mass:
    7645 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.

    Three dimensional structures from OCA and Proteopedia for POLR2L Gene

neXtProt entry for POLR2L Gene

Selected DME Specific Peptides for POLR2L Gene

Post-translational modifications for POLR2L Gene

  • Ubiquitination at Lys 41
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR2L Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for POLR2L Gene

Gene Families for POLR2L Gene

Suggested Antigen Peptide Sequences for POLR2L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62875

UniProtKB/Swiss-Prot:

RPAB5_HUMAN :
  • Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family.
Family:
  • Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2L: view

Function for POLR2L Gene

Molecular function for POLR2L Gene

GENATLAS Biochemistry:
polymerase II,RNA (DNA directed) small polypeptide L (7,6kDa),yeast RPB11 homolog
UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity).

Enzyme Numbers (IUBMB) for POLR2L Gene

Gene Ontology (GO) - Molecular Function for POLR2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001054 contributes_to RNA polymerase I activity IBA --
GO:0001055 contributes_to RNA polymerase II activity IBA --
GO:0001056 contributes_to RNA polymerase III activity IBA --
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed RNA polymerase activity TAS 8524256
genes like me logo Genes that share ontologies with POLR2L: view
genes like me logo Genes that share phenotypes with POLR2L: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2L Gene

Localization for POLR2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR2L Gene COMPARTMENTS Subcellular localization image for POLR2L gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 2

Gene Ontology (GO) - Cellular Components for POLR2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9852112
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex IDA 9852112
GO:0005666 DNA-directed RNA polymerase III complex IBA --
GO:0005736 DNA-directed RNA polymerase I complex IBA --
genes like me logo Genes that share ontologies with POLR2L: view

Pathways & Interactions for POLR2L Gene

SuperPathways for POLR2L Gene

SuperPathway Contained pathways
1 Formation of HIV elongation complex in the absence of HIV Tat
2 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
3 RNA Polymerase III Transcription Initiation
4 RNA Polymerase II Transcription Initiation And Promoter Clearance
5 mRNA Capping
genes like me logo Genes that share pathways with POLR2L: view

Gene Ontology (GO) - Biological Process for POLR2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006356 regulation of transcription from RNA polymerase I promoter TAS 8786124
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
genes like me logo Genes that share ontologies with POLR2L: view

No data available for SIGNOR curated interactions for POLR2L Gene

Drugs & Compounds for POLR2L Gene

(42) Drugs for POLR2L Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0
Actinomycin D Pharma RNA polymerase inhibitor 0

(38) Additional Compounds for POLR2L Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8

(1) ApexBio Compounds for POLR2L Gene

Compound Action Cas Number
Actinomycin D RNA polymerase inhibitor 50-76-0
genes like me logo Genes that share compounds with POLR2L: view

Transcripts for POLR2L Gene

mRNA/cDNA for POLR2L Gene

Unigene Clusters for POLR2L Gene

Polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2L Gene

No ASD Table

Relevant External Links for POLR2L Gene

GeneLoc Exon Structure for
POLR2L
ECgene alternative splicing isoforms for
POLR2L

Expression for POLR2L Gene

mRNA expression in normal human tissues for POLR2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR2L Gene

This gene is overexpressed in Pancreas (17.2) and Tlymphocyte (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POLR2L Gene



Protein tissue co-expression partners for POLR2L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLR2L Gene:

POLR2L

SOURCE GeneReport for Unigene cluster for POLR2L Gene:

Hs.441072
genes like me logo Genes that share expression patterns with POLR2L: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLR2L Gene

Orthologs for POLR2L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR2L 34 35
  • 100 (n)
mouse
(Mus musculus)
Mammalia Gm10774 35
  • 99 (a)
OneToMany
Polr2l 34 16 35
  • 89.55 (n)
cow
(Bos Taurus)
Mammalia POLR2L 34 35
  • 94.03 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911840 34
  • 88.06 (n)
chicken
(Gallus gallus)
Aves POLR2L 34 35
  • 82.59 (n)
lizard
(Anolis carolinensis)
Reptilia POLR2L 35
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2l.1 34
  • 78.61 (n)
Str.6602 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8250 34
zebrafish
(Danio rerio)
Actinopterygii polr2l 34 35
  • 80.1 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011761 34
  • 81.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rpb10 36 34 35
  • 79.6 (n)
worm
(Caenorhabditis elegans)
Secernentea Y37E3.3 36
  • 85 (a)
rpb-10 34 35
  • 73.63 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR163W 34
  • 68.66 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D06699g 34
  • 58.71 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB10 34 35 37
  • 58.21 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPB10 34
  • 70.65 (n)
rice
(Oryza sativa)
Liliopsida Os11g0194800 34
  • 77.61 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.6936 34
corn
(Zea mays)
Liliopsida Zm.7018 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4791 35
  • 90 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU02605 34
  • 73.96 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb10 34
  • 65.67 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3728 34
Species where no ortholog for POLR2L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for POLR2L Gene

ENSEMBL:
Gene Tree for POLR2L (if available)
TreeFam:
Gene Tree for POLR2L (if available)

Paralogs for POLR2L Gene

genes like me logo Genes that share paralogs with POLR2L: view

No data available for Paralogs for POLR2L Gene

Variants for POLR2L Gene

Sequence variations from dbSNP and Humsavar for POLR2L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10678550 -- 842,099(+) ACGGG(-/AA)AATAG intron-variant, upstream-variant-2KB
rs10902226 -- 843,097(+) GGCGG(C/G)TCTTC intron-variant, upstream-variant-2KB
rs111280028 -- 840,203(+) CCTTA(C/G/T)TGGTT utr-variant-3-prime
rs111329635 -- 842,412(+) GCCTC(A/C/T)CCCCT upstream-variant-2KB, splice-donor-variant
rs111475993 -- 840,617(+) CCCGG(A/C)TCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR2L Gene

Variant ID Type Subtype PubMed ID
dgv1013n100 CNV gain 25217958
dgv1526n54 CNV gain 21841781
dgv1527n54 CNV loss 21841781
dgv182e199 CNV deletion 23128226
esv2759794 CNV loss 17122850
nsv1040044 CNV gain+loss 25217958
nsv1048774 CNV gain 25217958
nsv1159791 CNV deletion 26073780
nsv469923 CNV loss 18288195
nsv552871 CNV loss 21841781
nsv552874 CNV gain 21841781
nsv552879 CNV loss 21841781
nsv552882 CNV loss 21841781
nsv552887 CNV loss 21841781
nsv552888 CNV loss 21841781
nsv832044 CNV loss 17160897
nsv8760 CNV loss 18304495
nsv951272 CNV deletion 24416366

Variation tolerance for POLR2L Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2L Gene

Disorders for POLR2L Gene

MalaCards: The human disease database

(2) MalaCards diseases for POLR2L Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
cockayne syndrome
  • cockayne's syndrome
hyperparathyroidism-jaw tumor syndrome
  • parathyroid adenoma with cystic changes
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POLR2L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2L
genes like me logo Genes that share disorders with POLR2L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR2L Gene

Publications for POLR2L Gene

  1. The HIV-1 Tat team gets bigger. (PMID: 20227660) Rice A.P. (Cell Host Microbe 2010) 3 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Domains in the SPT5 protein that modulate its transcriptional regulatory properties. (PMID: 10757782) Ivanov D. … Gaynor R.B. (Mol. Cell. Biol. 2000) 3 22 64
  4. The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat. (PMID: 9696809) Fujinaga K. … Peterlin B.M. (J. Virol. 1998) 3 22 64
  5. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PMID: 9852112) Kershnar E. … Chiang C.-M. (J. Biol. Chem. 1998) 3 4 64

Products for POLR2L Gene

Sources for POLR2L Gene

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