Aliases for POLR2L Gene
External Ids for POLR2L Gene
Previous GeneCards Identifiers for POLR2L Gene
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]
GeneCards Summary for POLR2L Gene
POLR2L (Polymerase (RNA) II (DNA Directed) Polypeptide L, 7.6kDa) is a Protein Coding gene. Diseases associated with POLR2L include hyperparathyroidism-jaw tumor syndrome and cockayne syndrome. Among its related pathways are Immune System and Developmental Biology. GO annotations related to this gene include DNA-directed RNA polymerase activity and RNA polymerase I activity.
UniProtKB/Swiss-Prot for POLR2L Gene
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity).