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Aliases for POLR2K Gene

Aliases for POLR2K Gene

  • RNA Polymerase II Subunit K 2 3 5
  • Polymerase (RNA) II (DNA Directed) Polypeptide K, 7.0kDa 2 3
  • RNA Polymerases I, II, And III Subunit ABC4 3 4
  • DNA-Directed RNA Polymerase II Subunit K 3 4
  • RNA Polymerase II 7.0 KDa Subunit 3 4
  • ABC10-Alpha 3 4
  • RPB10alpha 3 4
  • RPB7.0 3 4
  • DNA Directed RNA Polymerases I, II, And III 7.0 Kda Polypeptide 3
  • DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 3
  • Polymerase (RNA) II Subunit K 3
  • HsRPB10a 3
  • HRPB7.0 3
  • RPABC4 3
  • RPB12 3

External Ids for POLR2K Gene

Previous GeneCards Identifiers for POLR2K Gene

  • GC08P100168
  • GC08P101232
  • GC08P100831
  • GC08P101119
  • GC08P096365
  • GC08P101162

Summaries for POLR2K Gene

Entrez Gene Summary for POLR2K Gene

  • This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2K Gene

POLR2K (RNA Polymerase II Subunit K) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Formation of HIV elongation complex in the absence of HIV Tat. GO annotations related to this gene include DNA-directed 5-3 RNA polymerase activity and RNA polymerase I activity.

UniProtKB/Swiss-Prot for POLR2K Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.

Gene Wiki entry for POLR2K Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2K Gene

Genomics for POLR2K Gene

Regulatory Elements for POLR2K Gene

Enhancers for POLR2K Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G100525 1.5 Ensembl ENCODE dbSUPER 10.9 +377.3 377343 4.5 HDGF PKNOX1 FOXA2 ATF1 MLX ZFP64 ARID4B SIN3A YY1 ZNF143 ANKRD46 POLR2K FBXO43 ENSG00000253666 ENSG00000202310 SPAG1 ENSG00000253217 RNF19A RGS22 LOC105375674
GH08G100540 1 Ensembl ENCODE 12.4 +390.4 390417 0.4 ELF3 CTCF ZNF384 CEBPG RAD21 ZBTB40 RFX5 CBX5 SMC3 MIXL1 FBXO43 POLR2K ENSG00000202310 SPAG1 RGS22 GC08M100535 ENSG00000254364
GH08G100237 1.1 Ensembl ENCODE 10.9 +87.9 87891 1.8 PKNOX1 FOXA2 ATF1 TCF12 SCRT2 FOS CREM CEBPB ZNF592 MTA1 FBXO43 POLR2K ENSG00000253666 SPAG1 LOC105375668 LOC105375669
GH08G100218 1 Ensembl ENCODE 11.1 +68.3 68251 1.1 PKNOX1 ZNF316 ZNF207 NFE2 RELB IKZF2 CREM MTA2 BHLHE40 MAFG SPAG1 ENSG00000202310 FBXO43 POLR2K RGS22 LOC105375669 ENSG00000199667
GH08G100567 0.8 ENCODE 10.1 +417.0 416975 1.0 TAF1 TAL1 MAX RAD21 YY1 GATA3 EGR1 SCRT2 HNF4G MAFK RNU4-83P LOC105375671 SNX31 FBXO43 POLR2K PABPC1 RGS22 ANKRD46
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLR2K on UCSC Golden Path with GeneCards custom track

Promoters for POLR2K Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000227894 17 2000 HDGF PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1

Genomic Location for POLR2K Gene

Chromosome:
8
Start:
100,150,584 bp from pter
End:
100,154,002 bp from pter
Size:
3,419 bases
Orientation:
Plus strand

Genomic View for POLR2K Gene

Genes around POLR2K on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2K Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2K Gene

Proteins for POLR2K Gene

  • Protein details for POLR2K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53803-RPAB4_HUMAN
    Recommended name:
    DNA-directed RNA polymerases I, II, and III subunit RPABC4
    Protein Accession:
    P53803
    Secondary Accessions:
    • Q6IBD4

    Protein attributes for POLR2K Gene

    Size:
    58 amino acids
    Molecular mass:
    7004 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.

    Three dimensional structures from OCA and Proteopedia for POLR2K Gene

neXtProt entry for POLR2K Gene

Post-translational modifications for POLR2K Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POLR2K Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POLR2K Gene

Domains & Families for POLR2K Gene

Gene Families for POLR2K Gene

Protein Domains for POLR2K Gene

Suggested Antigen Peptide Sequences for POLR2K Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P53803

UniProtKB/Swiss-Prot:

RPAB4_HUMAN :
  • Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family.
Family:
  • Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2K: view

Function for POLR2K Gene

Molecular function for POLR2K Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.

Gene Ontology (GO) - Molecular Function for POLR2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001054 contributes_to RNA polymerase I activity IBA --
GO:0001055 contributes_to RNA polymerase II activity IBA --
GO:0001056 contributes_to RNA polymerase III activity IBA --
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed 5-3 RNA polymerase activity IEA --
genes like me logo Genes that share ontologies with POLR2K: view
genes like me logo Genes that share phenotypes with POLR2K: view

Animal Model Products

CRISPR Products

miRNA for POLR2K Gene

miRTarBase miRNAs that target POLR2K

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2K Gene

Localization for POLR2K Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2K Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR2K gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for POLR2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 9852112
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex IDA 9852112
GO:0005666 DNA-directed RNA polymerase III complex IBA --
GO:0005736 DNA-directed RNA polymerase I complex IBA --
genes like me logo Genes that share ontologies with POLR2K: view

Pathways & Interactions for POLR2K Gene

SuperPathways for POLR2K Gene

SuperPathway Contained pathways
1 Formation of HIV elongation complex in the absence of HIV Tat
2 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
3 RNA Polymerase II Transcription Initiation And Promoter Clearance
4 RNA Polymerase III Transcription Initiation
5 mRNA Capping
genes like me logo Genes that share pathways with POLR2K: view

Gene Ontology (GO) - Biological Process for POLR2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated TAS,IEA --
GO:0006356 regulation of transcription from RNA polymerase I promoter TAS 7651387
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
genes like me logo Genes that share ontologies with POLR2K: view

No data available for SIGNOR curated interactions for POLR2K Gene

Drugs & Compounds for POLR2K Gene

(4) Drugs for POLR2K Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0

(1) Additional Compounds for POLR2K Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with POLR2K: view

Transcripts for POLR2K Gene

mRNA/cDNA for POLR2K Gene

Unigene Clusters for POLR2K Gene

Polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2K Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: -
SP3:

Relevant External Links for POLR2K Gene

GeneLoc Exon Structure for
POLR2K
ECgene alternative splicing isoforms for
POLR2K

Expression for POLR2K Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR2K Gene

Protein differential expression in normal tissues from HIPED for POLR2K Gene

This gene is overexpressed in Breast (16.7), Fetal Brain (8.5), and Blymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POLR2K Gene



NURSA nuclear receptor signaling pathways regulating expression of POLR2K Gene:

POLR2K

SOURCE GeneReport for Unigene cluster for POLR2K Gene:

Hs.351475

Evidence on tissue expression from TISSUES for POLR2K Gene

  • Nervous system(3.7)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with POLR2K: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR2K Gene

Orthologs for POLR2K Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POLR2K Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR2K 34 35
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia POLR2K 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POLR2K 34 35
  • 95.4 (n)
dog
(Canis familiaris)
Mammalia POLR2K 34 35
  • 95.4 (n)
rat
(Rattus norvegicus)
Mammalia Polr2k 34
  • 94.83 (n)
mouse
(Mus musculus)
Mammalia Polr2k 34 16 35
  • 92.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia POLR2K 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves POLR2K 35
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLR2K 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2k 34
  • 85.63 (n)
Str.6978 34
zebrafish
(Danio rerio)
Actinopterygii polr2k 34 35
  • 81.03 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rpb12 35
  • 68 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpb-12 35
  • 58 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPC10 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2976 35
  • 56 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13296 34
Species where no ortholog for POLR2K was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR2K Gene

ENSEMBL:
Gene Tree for POLR2K (if available)
TreeFam:
Gene Tree for POLR2K (if available)

Paralogs for POLR2K Gene

Pseudogenes.org Pseudogenes for POLR2K Gene

genes like me logo Genes that share paralogs with POLR2K: view

No data available for Paralogs for POLR2K Gene

Variants for POLR2K Gene

Sequence variations from dbSNP and Humsavar for POLR2K Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000663325 -- 100,149,412(+) ACAAT(A/G)GTTCC intron-variant, upstream-variant-2KB
rs1000995077 -- 100,150,767(+) AAAGA(C/G)ACTTG intron-variant, upstream-variant-2KB
rs1001914076 -- 100,149,342(+) ATATA(C/G)AAGAG intron-variant, upstream-variant-2KB
rs1002240647 -- 100,151,121(+) TTATG(A/T)AGATT intron-variant, upstream-variant-2KB
rs1002438404 -- 100,151,429(+) TAGCA(C/T)TTACC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for POLR2K Gene

Variant ID Type Subtype PubMed ID
nsv611814 CNV loss 21841781

Variation tolerance for POLR2K Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR2K Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR2K

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2K Gene

Disorders for POLR2K Gene

Relevant External Links for POLR2K

Genetic Association Database (GAD)
POLR2K
Human Genome Epidemiology (HuGE) Navigator
POLR2K
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2K

No disorders were found for POLR2K Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR2K Gene

Publications for POLR2K Gene

  1. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T. … Friedman E. (Int. J. Cancer 2010) 3 46 64
  2. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PMID: 19237606) Michiels S. … Benhamou S. (Carcinogenesis 2009) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae. (PMID: 7651387) Shpakovski G.V. … Vigneron M. (Mol. Cell. Biol. 1995) 3 4 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for POLR2K Gene

Sources for POLR2K Gene

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