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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POLR2K Gene

protein-coding   GIFtS: 58
GCID: GC08P101162

Polymerase (RNA) II (DNA Directed) Polypeptide K, 7.0kDa

(Previous name: polymerase (RNA) II (DNA directed) polypeptide K (7.0kD))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Polymerase (RNA) II (DNA Directed) Polypeptide K, 7.0kDa1 2     RPB122 5
ABC10-alpha2 3     Polymerase (RNA) II (DNA Directed) Polypeptide K (7.0kD)1
RPB10alpha2 3     RPABC42
RPB7.02 3     DNA Directed RNA Polymerases I, II, And III 7.0 Kda Polypeptide2
DNA-Directed RNA Polymerase II Subunit K2 3     DNA-Directed RNA Polymerases I, II, And III Subunit RPABC42
RNA Polymerase II 7.0 KDa Subunit2 3     hRPB7.02
RNA Polymerases I, II, And III Subunit ABC42 3     hsRPB10a2

External Ids:    HGNC: 91981   Entrez Gene: 54402   Ensembl: ENSG000001476697   OMIM: 6060335   UniProtKB: P538033   

Export aliases for POLR2K gene to outside databases

Previous GC identifers: GC08P100168 GC08P101232 GC08P100831 GC08P101119 GC08P096365


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POLR2K Gene:
This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing
messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. (provided by
RefSeq, Jul 2008)

GeneCards Summary for POLR2K Gene: 
POLR2K (polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa) is a protein-coding gene. Diseases associated with POLR2K include conjunctivitis, and huntington's disease, and among its related super-pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and RNA Polymerase III Transcription Initiation. GO annotations related to this gene include DNA-directed RNA polymerase activity and DNA binding.

UniProtKB/Swiss-Prot: RPAB4_HUMAN, P53803
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA
precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs,
respectively

Gene Wiki entry for POLR2K Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POLR2K gene promoter:
         C/EBPbeta   GATA-3   Nkx2-2   CUTL1   GATA-2   GATA-1   SRY   POU2F1   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOLR2K promoter sequence
   Search SABiosciences Chromatin IP Primers for POLR2K

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLR2K


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.2   Ensembl cytogenetic band:  8q22.2   HGNC cytogenetic band: 8q22

POLR2K Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR2K gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P101162:  view genomic region     (about GC identifiers)

Start:
101,162,812 bp from pter      End:
101,166,230 bp from pter
Size:
3,419 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RPAB4_HUMAN, P53803 (See protein sequence)
Recommended Name: DNA-directed RNA polymerases I, II, and III subunit RPABC4  
Size: 58 amino acids; 7004 Da
Subunit: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III)
complexes consisting of at least 13, 12 and 17 subunits, respectively (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q6IBD4

Explore the universe of human proteins at neXtProt for POLR2K: NX_P53803

Explore proteomics data for POLR2K at MOPED 

POLR2K Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

POLR2K Protein Expression

REFSEQ proteins: NP_005025.1  
ENSEMBL proteins: 
 ENSP00000342889   ENSP00000430106  
Reactome Protein details: P53803
Human Recombinant Protein Products for POLR2K: 
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Novus Biologicals POLR2K Proteins
Novus Biologicals POLR2K Lysate
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Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for POLR2K 

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA9852112
GO:0005654nucleoplasm TAS--
GO:0005665DNA-directed RNA polymerase II, core complex IDA9852112
GO:0005829cytosol TAS--

POLR2K for ontologies           About GeneDecksing



POLR2K Antibody Products: 
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Abcam antibodies for POLR2K
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ThermoFisher Antibodies for POLR2K
LSBio Antibodies in human, mouse, rat for POLR2K 

Assay Products for POLR2K: 
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Cloud-Clone Corp. ELISAs for POLR2K 
Cloud-Clone Corp. CLIAs for POLR2K


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
POLR: RNA polymerase subunits

1 InterPro protein domain:
 IPR006591 RNAP_P/RPC10

Graphical View of Domain Structure for InterPro Entry P53803

ProtoNet protein and cluster: P53803

1 Blocks protein domain: IPB006591 RNA polymerase Rbp10

UniProtKB/Swiss-Prot: RPAB4_HUMAN, P53803
Similarity: Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family


POLR2K for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: RPAB4_HUMAN, P53803
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA
precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs,
respectively

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0003899DNA-directed RNA polymerase activity IEA--
GO:0008270zinc ion binding TAS7651387
     
POLR2K for ontologies           About GeneDecksing


Phenotypes:
     3 GenomeRNAi human phenotypes for POLR2K:
 Decreased viability of wild-ty  Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for POLR2K 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POLR2K

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POLR2K 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POLR2K 

miRNA
Products:
    
miRTarBase miRNAs that target POLR2K:
hsa-mir-1 (MIRT002738)

QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLR2K
1 QIAGEN miScript miRNA Assays for microRNA that regulate POLR2K:
hsa-miR-34a*
SwitchGear 3'UTR luciferase reporter plasmidPOLR2K 3' UTR sequence
Inhib. RNA
Products:
    
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Gene Editing
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Clone
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OriGene clones in human, mouse for POLR2K (see all 7)
OriGene ORF clones in mouse, rat for POLR2K
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: POLR2K (NM_005034)
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Cell Line
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In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2K


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for POLR2K About   (see all 19)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1Formation of RNA Pol II elongation complex
RNA Pol II CTD phosphorylation and interaction with CE0.93
Pausing and recovery of Tat-mediated HIV elongation0.73
RNA Pol II CTD phosphorylation and interaction with CE0.93
Tat-mediated HIV elongation arrest and recovery0.73
mRNA Capping0.93
RNA Polymerase II Pre-transcription Events0.72
HIV Transcription Elongation0.78
Abortive elongation of HIV-1 transcript in the absence of Tat0.72
2RNA Polymerase III Transcription Initiation
RNA Polymerase III Transcription Initiation0.80
RNA Polymerase III Transcription Initiation From Type 2 Promoter0.74
RNA Polymerase III Transcription0.80
RNA Polymerase III Chain Elongation0.69
RNA Polymerase III Abortive And Retractive Initiation0.80
RNA Polymerase III Transcription Termination0.69
RNA Polymerase III Transcription Initiation From Type 3 Promoter0.80
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.59
3Purine metabolism
Purine metabolism0.38
ATP/ITP metabolism0.31
Pyrimidine metabolism0.38
4Cytosolic DNA-sensing pathway
Cytosolic DNA-sensing pathway0.36
Cytosolic sensors of pathogen-associated DNA 0.36
5RNA Polymerase I Chain Elongation
RNA Polymerase I Promoter Clearance0.92
RNA Polymerase I Chain Elongation0.90
RNA Polymerase I Transcription0.92
RNA Polymerase I Transcription Initiation0.90
RNA Polymerase I Promoter Escape0.91
RNA Polymerase I Transcription Termination0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

3 EMD Millipore Pathways for POLR2K
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
DNA damage Role of Brca1 and Brca2 in DNA repair
ATP/ITP metabolism

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POLR2K
    Assembly of RNA Polymerase-II Initiation Complex
Transcription of mRNA

3 GeneGo (Thomson Reuters) Pathways for POLR2K
    DNA damage Role of Brca1 and Brca2 in DNA repair
ATP/ITP metabolism
Transcription Ligand-Dependent Transcription of Retinoid-Target genes

1 BioSystems Pathway for POLR2K
    Eukaryotic Transcription Initiation

5/62        Reactome Pathways for POLR2K (see all 62)
    RNA Polymerase III Transcription Initiation
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
mRNA Splicing
RNA Polymerase III Chain Elongation


5/7         Kegg Pathways  (Kegg details for POLR2K) (see all 7):
    Purine metabolism
Pyrimidine metabolism
Metabolic pathways
RNA polymerase
Cytosolic DNA-sensing pathway


POLR2K for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POLR2K

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/85 Interacting proteins for POLR2K (P538033 ENSP000003428894) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
InteractantInteraction Details
GeneCardExternal ID(s)
POLR2CP193873, ENSP000002192524I2D: score=3 STRING: ENSP00000219252
POLR2EP193883, ENSP000002155874I2D: score=3 STRING: ENSP00000215587
POLR2HP524343, ENSP000002962234I2D: score=3 STRING: ENSP00000296223
MED10Q9BTT43, ENSP000002557644I2D: score=2 STRING: ENSP00000255764
BRCA1P383983, ENSP000003502834I2D: score=1 STRING: ENSP00000350283
About this table

Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000398mRNA splicing, via spliceosome TAS--
GO:0006281DNA repair TAS--
GO:0006283transcription-coupled nucleotide-excision repair TAS--
GO:0006289nucleotide-excision repair TAS--
GO:0006351transcription, DNA-dependent ----

POLR2K for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
EMD Millipore small molecules for POLR2K:
Small Molecule - inhibitor
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for POLR2K (RPAB4)

Search CenterWatch for drugs/clinical trials and news about POLR2K / RPAB4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for POLR2K gene: 
NM_005034.3  

Unigene Cluster for POLR2K:

Polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
Hs.351475  [show with all ESTs]
Unigene Representative Sequence: BI758413
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000353107(uc003yjf.3) ENST00000522439 ENST00000519765
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLR2K
1 QIAGEN miScript miRNA Assays for microRNA that regulate POLR2K:
hsa-miR-34a*
SwitchGear 3'UTR luciferase reporter plasmidPOLR2K 3' UTR sequence
Inhib. RNA
Products:
     
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OriGene RNAi products in human, mouse, rat for POLR2K
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Clone
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OriGene clones in human, mouse for POLR2K (see all 7)
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GenScript: all cDNA clones in your preferred vector: POLR2K (NM_005034)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLR2K
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR2K
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                     Customized lentivirus expression plasmids for stable overexpression of POLR2K 
Primer
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OriGene qPCR primer pairs and template standards for POLR2K
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POLR2K
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR2K
  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR2K

Additional mRNA sequence: 

BC000806.1 BC018157.1 CR456870.1 Z47727.1 

6 DOTS entries:

DT.95083184  DT.100823137  DT.95083186  DT.100823136  DT.92453635  DT.121486953 

24/382 AceView cDNA sequences (see all 382):

AA382785 BQ773893 AI191008 CA413937 BM784560 N75678 BE380008 AI378641 
BG035530 AA442109 BU949864 AI095356 AI140529 AI374611 AA778417 CB115719 
N53469 AW571777 CF130829 BM760439 CR597305 BF034187 AA527598 AA843767 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for POLR2K    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1:                                -               
SP2:                                -               
SP3:                                                


ECgene alternative splicing isoforms for POLR2K

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

POLR2K expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TACCAGCGCC
POLR2K Expression
About this image


See POLR2K Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POLR2K

SOURCE GeneReport for Unigene cluster: Hs.351475
    SABiosciences Custom PCR Arrays for POLR2K
Primer
Products:
OriGene qPCR primer pairs and template standards for POLR2K
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR2K
Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR2K
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2K

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for POLR2K gene from 7/16 species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Polr2k1 , 5 polymerase (RNA) II (DNA directed) polypeptide K1, 5 92.53(n)1
98.28(a)1
  15 (14.46 cM)5
177491  NM_001039368.11  NP_001034457.11 
 361740105 
chicken
(Gallus gallus)
Aves LOC7716261 DNA-directed RNA polymerases I, II, and III subunit more 86.78(n)
96.55(a)
  771626  XM_001234882.2  XP_001234883.2 
lizard
(Anolis carolinensis)
Reptilia POLR2K6
polymerase (RNA) II (DNA directed) polypeptide K, ...
91(a)
1 ↔ 1
GL343394.1(298157-303987)
African clawed frog
(Xenopus laevis)
Amphibia CB944338.12   -- 84.18(n)    CB944338.1 
zebrafish
(Danio rerio)
Actinopterygii polr2k1 polymerase (RNA) II (DNA directed) polypeptide K 81.03(n)
94.83(a)
  796803  NM_001199106.1  NP_001186035.1 
fruit fly
(Drosophila melanogaster)
Insecta Rpb126
Rpb12
70(a)
1 ↔ 1
2R(11032473-11033024)
worm
(Caenorhabditis elegans)
Secernentea rpb-126
Protein RPB-12
60(a)
1 ↔ 1
IV(9146339-9147031)


ENSEMBL Gene Tree for POLR2K (if available)
TreeFam Gene Tree for POLR2K (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for POLR2K gene

POLR2K for paralogs           About GeneDecksing


3 Pseudogenes.org Pseudogenes for POLR2K
PGOHUM00000239769 PGOHUM00000256722 PGOHUM00000240586


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/134 SNPs in POLR2K are shown (see all 134)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1837789901,2
--101160863(+) CTTGAA/TCTCCT 1 -- us2k10--------
rs1879429061,2
--101160921(+) CAGGCA/GTGAGC 1 -- us2k10--------
rs582013071,2
C,F--101160930(+) GCCACG/AGTGCC 1 -- us2k13Minor allele frequency- A:0.10WA CSA 122
rs24469231,2
C--101160981(+) TCACTG/AATTTC 1 -- us2k1 tfbs38Minor allele frequency- A:0.00NA WA CSA EA 367
rs1118410741,2
C--101160982(+) CACTAG/ATTTCA 1 -- us2k11Minor allele frequency- A:0.00CSA 1
rs24536371,2
C,F,H--101160983(+) ACTAAT/CTTCAG 1 -- us2k1 tfbs312Minor allele frequency- C:0.48NS EA NA WA CSA 765
rs285458011,2
C,F--101161183(+) TTCTTA/TATAAA 1 -- us2k11Minor allele frequency- T:0.09WA 118
rs285769931,2
C,F--101161186(+) TTAATA/TAAGAG 1 -- us2k11Minor allele frequency- T:0.09WA 118
rs1895700291,2
--101161376(+) AGAGCA/GTGTTG 1 -- us2k10--------
rs1481836391,2
--101161534(+) CACGAC/GAATTA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for POLR2K (101162812 - 101166230 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for POLR2K: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing POLR2K
DNA2.0 Custom Variant and Variant Library Synthesis for POLR2K

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 606033    OMIM disorders: --

5 diseases for POLR2K:    About MalaCards
conjunctivitis    huntington's disease    hepatitis c    ovarian cancer
hepatitis


POLR2K for disorders           About GeneDecksing

Genetic Association Database (GAD): POLR2K
Human Genome Epidemiology (HuGE) Navigator: POLR2K (2 documents)

Export disorders for POLR2K gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for POLR2K gene, integrated from 9 sources (see all 100):
(articles sorted by number of sources associating them with POLR2K)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Single nucleotide polymorphisms in miRNA binding site s and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk w omen. (PubMed id 19950226)1, 4 Kontorovich T....Friedman E. (2009)
  2. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (2009)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae. (PubMed id 7651387)1, 2 Shpakovski G.V....Vigneron M. (1995)
  5. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
  6. Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development. (PubMed id 22422068)1 Dahiya S....Wigdahl B. (2012)
  7. Human mediator subunit MED26 functions as a docking s ite for transcription elongation factors. (PubMed id 21729782)1 Takahashi H....Conaway J.W. (2011)
  8. HIV latency. (PubMed id 22229121)1 Siliciano R.F. and Greene W.C. (2011)
  9. New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC). (PubMed id 21360054)1 He N. and Zhou Q. (2011)
  10. The Role of RNA Polymerase II Elongation Control in HI V-1 Gene Expression, Replication, and Latency. (PubMed id 22567366)1 Nilson K.A. and Price D.H. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 5440 HGNC: 9198 AceView: POLR2K Ensembl:ENSG00000147669 euGenes: HUgn5440
ECgene: POLR2K Kegg: 5440 H-InvDB: POLR2K

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for POLR2K Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for POLR2K gene:
Search GeneIP for patents involving POLR2K

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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