Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



POLR2K Gene

protein-coding   GIFtS: 57
GCID: GC08P101162

Polymerase (RNA) II (DNA Directed) Polypeptide K, 7.0kDa

(Previous name: polymerase (RNA) II (DNA directed) polypeptide K (7.0kD))
  See POLR2K-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Polymerase (RNA) II (DNA Directed) Polypeptide K, 7.0kDa1 2     RPB122 5
ABC10-alpha2 3     Polymerase (RNA) II (DNA Directed) Polypeptide K (7.0kD)1
RPB10alpha2 3     RPABC42
RPB7.02 3     DNA Directed RNA Polymerases I, II, And III 7.0 Kda Polypeptide2
DNA-Directed RNA Polymerase II Subunit K2 3     DNA-Directed RNA Polymerases I, II, And III Subunit RPABC42
RNA Polymerase II 7.0 KDa Subunit2 3     hRPB7.02
RNA Polymerases I, II, And III Subunit ABC42 3     hsRPB10a2

External Ids:    HGNC: 91981   Entrez Gene: 54402   Ensembl: ENSG000001476697   OMIM: 6060335   UniProtKB: P538033   

Export aliases for POLR2K gene to outside databases

Previous GC identifers: GC08P100168 GC08P101232 GC08P100831 GC08P101119 GC08P096365


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for POLR2K Gene:
This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing
messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. (provided by
RefSeq, Jul 2008)

GeneCards Summary for POLR2K Gene:
POLR2K (polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa) is a protein-coding gene. Diseases associated with POLR2K include hiv-1. GO annotations related to this gene include DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot: RPAB4_HUMAN, P53803
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA
precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs,
respectively

Gene Wiki entry for POLR2K Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the POLR2K gene promoter:
         C/EBPbeta   GATA-3   Nkx2-2   CUTL1   GATA-2   GATA-1   SRY   POU2F1   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOLR2K promoter sequence
   Search Chromatin IP Primers for POLR2K

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POLR2K


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.2   Ensembl cytogenetic band:  8q22.2   HGNC cytogenetic band: 8q22

POLR2K Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR2K gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P101162:  view genomic region     (about GC identifiers)

Start:
101,162,812 bp from pter      End:
101,166,230 bp from pter
Size:
3,419 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RPAB4_HUMAN, P53803 (See protein sequence)
Recommended Name: DNA-directed RNA polymerases I, II, and III subunit RPABC4  
Size: 58 amino acids; 7004 Da
Subunit: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III)
complexes consisting of at least 13, 12 and 17 subunits, respectively (By similarity)
Secondary accessions: Q6IBD4

Explore the universe of human proteins at neXtProt for POLR2K: NX_P53803

Explore proteomics data for POLR2K at MOPED


See POLR2K Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_005025.1  
ENSEMBL proteins: 
 ENSP00000342889   ENSP00000430106  
Reactome Protein details: P53803

POLR2K Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for POLR2K
OriGene Protein Over-expression Lysate for POLR2K
OriGene MassSpec for POLR2K
OriGene Custom Protein Services for POLR2K
GenScript Custom Purified and Recombinant Proteins Services for POLR2K
Novus Biologicals POLR2K Proteins
Novus Biologicals POLR2K Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for POLR2K

 
Search eBioscience for Proteins for POLR2K 

POLR2K Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for POLR2K
Novus Biologicals POLR2K Antibodies
Abcam antibodies for POLR2K
Cloud-Clone Corp. Antibodies for POLR2K
ThermoFisher Antibodies for POLR2K
LSBio Antibodies in human, mouse, rat for POLR2K

POLR2K Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for POLR2K
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for POLR2K
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for POLR2K
Cloud-Clone Corp. CLIAs for POLR2K
Search eBioscience for ELISAs for POLR2K 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
POLR: RNA polymerase subunits

1 InterPro protein domain:
 IPR006591 RNAP_P/RPC10

Graphical View of Domain Structure for InterPro Entry P53803

ProtoNet protein and cluster: P53803

1 Blocks protein domain: IPB006591 RNA polymerase Rbp10

UniProtKB/Swiss-Prot: RPAB4_HUMAN, P53803
Similarity: Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family


Find genes that share domains with POLR2K           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: RPAB4_HUMAN, P53803
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA
precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs,
respectively

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001054contributes to RNA polymerase I activity IBA--
GO:0001055contributes to RNA polymerase II activity IBA--
GO:0001056contributes to RNA polymerase III activity IBA--
GO:0003677DNA binding IEA--
GO:0003899DNA-directed RNA polymerase activity ----
     
Find genes that share ontologies with POLR2K           About GenesLikeMe


Phenotypes:
     3 GenomeRNAi human phenotypes for POLR2K:
 Decreased viability of wild-ty  Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POLR2K
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for POLR2K

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POLR2K
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POLR2K

miRNA
Products:
    
miRTarBase miRNAs that target POLR2K:
hsa-mir-1 (MIRT002738)

Block miRNA regulation of human, mouse, rat POLR2K using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate POLR2K:
hsa-miR-34a*
SwitchGear 3'UTR luciferase reporter plasmidPOLR2K 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for POLR2K
Predesigned siRNA for gene silencing in human, mouse, rat POLR2K

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for POLR2K

Clone
Products:
     
OriGene clones in human, mouse for POLR2K (see all 6)
OriGene ORF clones in mouse, rat for POLR2K
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: POLR2K (NM_005034)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLR2K
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR2K

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for POLR2K
Browse ESI BIO Cell Lines and PureStem Progenitors for POLR2K 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2K


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
RPAB4_HUMAN, P53803: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
extracellular2
cytosol1
mitochondrion1

Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA9852112
GO:0005654nucleoplasm TAS--
GO:0005665DNA-directed RNA polymerase II, core complex IDA9852112
GO:0005666DNA-directed RNA polymerase III complex IBA--
GO:0005736DNA-directed RNA polymerase I complex IBA--

Find genes that share ontologies with POLR2K           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for POLR2K About   (see all 19)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1Formation of RNA Pol II elongation complex
mRNA Capping0.93
Pausing and recovery of Tat-mediated HIV elongation0.72
RNA Pol II CTD phosphorylation and interaction with CE0.93
Tat-mediated HIV elongation arrest and recovery0.72
RNA Pol II CTD phosphorylation and interaction with CE0.93
Transcription of the HIV genome0.71
Formation of the Early Elongation Complex0.77
Abortive elongation of HIV-1 transcript in the absence of Tat0.70
2RNA Polymerase III Transcription Initiation
RNA Polymerase III Transcription Initiation0.88
RNA Polymerase III Transcription Initiation From Type 2 Promoter0.74
RNA Polymerase III Abortive And Retractive Initiation0.88
RNA Polymerase III Transcription Termination0.58
RNA Polymerase III Transcription0.88
RNA polymerase0.45
RNA Polymerase III Transcription Initiation From Type 3 Promoter0.80
RNA Polymerase III Chain Elongation0.00
3Purine metabolism (KEGG)
Purine metabolism0.38
ATP ITP metabolism0.31
Pyrimidine metabolism0.38
4Cytosolic sensors of pathogen-associated DNA
Cytosolic sensors of pathogen-associated DNA0.38
Cytosolic DNA-sensing pathway0.33
5DNA Repair
Transcription-coupled NER (TC-NER)0.90
Formation of transcription-coupled NER (TC-NER) repair complex0.65
Nucleotide Excision Repair0.90
DNA Repair0.45
Dual incision reaction in TC-NER0.65


Find genes that share SuperPaths with POLR2K           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for POLR2K
    Assembly of RNA Polymerase-II Initiation Complex
Transcription of mRNA

3 GeneGo (Thomson Reuters) Pathways for POLR2K
    DNA damage Role of Brca1 and Brca2 in DNA repair
ATP/ITP metabolism
Transcription Ligand-Dependent Transcription of Retinoid-Target genes

1 BioSystems Pathway for POLR2K
    Eukaryotic Transcription Initiation

Selected Reactome Pathways for POLR2K (see all 43)
    Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
RNA Polymerase III Chain Elongation
RNA Polymerase I Promoter Escape
RNA Polymerase II Transcription Initiation And Promoter Clearance


Selected Kegg Pathways  (Kegg details for POLR2K) (see all 7):
    Purine metabolism
Pyrimidine metabolism
Metabolic pathways
RNA polymerase
Cytosolic DNA-sensing pathway

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POLR2K
Interactions:

    GeneGlobe Interaction Network for POLR2K

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for POLR2K (P538033 ENSP000003428894) via UniProtKB, MINT, STRING, and/or I2D (see all 118)
InteractantInteraction Details
GeneCardExternal ID(s)
POLR2CP193873, ENSP000002192524I2D: score=3 STRING: ENSP00000219252
POLR2EP193883, ENSP000002155874I2D: score=3 STRING: ENSP00000215587
POLR2HP524343, ENSP000002962234I2D: score=3 STRING: ENSP00000296223
MED10Q9BTT43, ENSP000002557644I2D: score=2 STRING: ENSP00000255764
BRCA1P383983, ENSP000003502834I2D: score=1 STRING: ENSP00000350283
About this table

Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000398mRNA splicing, via spliceosome TAS--
GO:0006281DNA repair TAS--
GO:0006283transcription-coupled nucleotide-excision repair TAS--
GO:0006289nucleotide-excision repair TAS--
GO:0006351transcription, DNA-templated ----

Find genes that share ontologies with POLR2K           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for POLR2K (RPAB4)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for POLR2K gene: 
NM_005034.3  

Unigene Cluster for POLR2K:

Polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
Hs.351475  [show with all ESTs]
Unigene Representative Sequence: BI758413
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000353107(uc003yjf.3) ENST00000522439 ENST00000519765
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat POLR2K using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate POLR2K:
hsa-miR-34a*
SwitchGear 3'UTR luciferase reporter plasmidPOLR2K 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for POLR2K
Predesigned siRNA for gene silencing in human, mouse, rat POLR2K
Clone
Products:
     
OriGene clones in human, mouse for POLR2K (see all 6)
OriGene ORF clones in mouse, rat for POLR2K
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: POLR2K (NM_005034)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLR2K
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR2K
Primer
Products:
    
OriGene qPCR primer pairs and template standards for POLR2K
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POLR2K
  QuantiTect SYBR Green Assays in human, mouse, rat POLR2K
  Search QuantiFast Probe-based Assays in human, mouse, rat POLR2K

Additional mRNA sequence: 

BC000806.1 BC018157.1 CR456870.1 Z47727.1 

6 DOTS entries:

DT.95083184  DT.100823137  DT.95083186  DT.100823136  DT.92453635  DT.121486953 

Selected AceView cDNA sequences (see all 382):

BU623200 AI080051 R22730 CR610014 AA127853 AA447892 BG612962 BC018157 
BG035530 BU659762 AV715093 AI140525 AI378641 AA442109 BM773116 CB160782 
BI826317 AV715841 BM840694 AA406507 CA442497 AA458646 AA382785 BQ773893 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for POLR2K    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1:                                -               
SP2:                                -               
SP3:                                                


ECgene alternative splicing isoforms for POLR2K

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

POLR2K expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TACCAGCGCC
POLR2K Expression
About this image

POLR2K Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

POLR2K Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.351475
    Custom PCR Arrays for POLR2K
Primer
Products:
OriGene qPCR primer pairs and template standards for POLR2K
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POLR2K
QuantiTect SYBR Green Assays in human, mouse, rat POLR2K
Search QuantiFast Probe-based Assays in human, mouse, rat POLR2K
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2K

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for POLR2K gene from Selected species (see all 17)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Polr2k1 , 5 polymerase (RNA) II (DNA directed) polypeptide K1, 5 92.53(n)1
98.28(a)1
  15 (14.46 cM)5
177491  NM_001039368.21  NP_001034457.11 
 361740105 
chicken
(Gallus gallus)
Aves POLR2K6
polymerase (RNA) II (DNA directed) polypeptide K, ...
97(a)
1 ↔ 1
2(128171123-128173950)
lizard
(Anolis carolinensis)
Reptilia POLR2K6
polymerase (RNA) II (DNA directed) polypeptide K, ...
91(a)
1 ↔ 1
GL343394.1(298157-303987)
African clawed frog
(Xenopus laevis)
Amphibia CB944338.12   -- 84.18(n)    CB944338.1 
zebrafish
(Danio rerio)
Actinopterygii polr2k1 polymerase (RNA) II (DNA directed) polypeptide K 81.03(n)
94.83(a)
  796803  NM_001199106.1  NP_001186035.1 
fruit fly
(Drosophila melanogaster)
Insecta Rpb126
Rpb12
68(a)
1 ↔ 1
2R(11032473-11033024)
worm
(Caenorhabditis elegans)
Secernentea rpb-126
Protein RPB-12 (rpb-12) mRNA, complete cds
58(a)
1 ↔ 1
IV(9146339-9147031) WBGene00009078


ENSEMBL Gene Tree for POLR2K (if available)
TreeFam Gene Tree for POLR2K (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for POLR2K gene

Find genes that share paralogs with POLR2K           About GenesLikeMe


3 Pseudogenes.org Pseudogenes for POLR2K
PGOHUM00000239769 PGOHUM00000256722 PGOHUM00000240586


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for POLR2K (see all 134)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1837789901,2
--101160863(+) CTTGAA/TCTCCT 1 -- us2k10--------
rs1879429061,2
--101160921(+) CAGGCA/GTGAGC 1 -- us2k10--------
rs582013071,2
C,F--101160930(+) GCCACG/AGTGCC 1 -- us2k13Minor allele frequency- A:0.10WA CSA 122
rs24469231,2
C--101160981(+) TCACTG/AATTTC 1 -- us2k1 tfbs38Minor allele frequency- A:0.00NA WA CSA EA 367
rs1118410741,2
C--101160982(+) CACTAG/ATTTCA 1 -- us2k11Minor allele frequency- A:0.00CSA 1
rs24536371,2
C,F,H--101160983(+) ACTAAT/CTTCAG 1 -- us2k1 tfbs312Minor allele frequency- C:0.48NS EA NA WA CSA 765
rs285458011,2
C,F--101161183(+) TTCTTA/TATAAA 1 -- us2k11Minor allele frequency- T:0.09WA 118
rs285769931,2
C,F--101161186(+) TTAATA/TAAGAG 1 -- us2k11Minor allele frequency- T:0.09WA 118
rs1895700291,2
--101161376(+) AGAGCA/GTGTTG 1 -- us2k10--------
rs1481836391,2
--101161534(+) CACGAC/GAATTA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for POLR2K (101162812 - 101166230 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for POLR2K: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing POLR2K
DNA2.0 Custom Variant and Variant Library Synthesis for POLR2K

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 606033    OMIM disorders: --

1 disease for POLR2K:    
About MalaCards
hiv-1


Find genes that share disorders with POLR2K           About GenesLikeMe

Genetic Association Database (GAD): POLR2K
Human Genome Epidemiology (HuGE) Navigator: POLR2K (2 documents)

Export disorders for POLR2K gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for POLR2K gene, integrated from 10 sources (see all 100):
(articles sorted by number of sources associating them with POLR2K)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PubMed id 19950226)1, 4 Kontorovich T....Friedman E. (Int. J. Cancer 2010)
  2. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (Carcinogenesis 2009)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae. (PubMed id 7651387)1, 2 Shpakovski G.V....Vigneron M. (Mol. Cell. Biol. 1995)
  5. Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development. (PubMed id 22422068)1 Dahiya S....Wigdahl B. (J. Gen. Virol. 2012)
  6. Human mediator subunit MED26 functions as a docking site for transcription elongation factors. (PubMed id 21729782)1 Takahashi H....Conaway J.W. (Cell 2011)
  7. HIV latency. (PubMed id 22229121)1 Siliciano R.F. and Greene W.C. (Cold Spring Harb Perspect Med 2011)
  8. New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC). (PubMed id 21360054)1 He N. and Zhou Q. (J Neuroimmune Pharmacol 2011)
  9. The Role of RNA Polymerase II Elongation Control in HIV-1 Gene Expression, Replication, and Latency. (PubMed id 22567366)1 Nilson K.A. and Price D.H. (Genet Res Int 2011)
  10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 5440 HGNC: 9198 AceView: POLR2K Ensembl:ENSG00000147669 euGenes: HUgn5440
ECgene: POLR2K Kegg: 5440 H-InvDB: POLR2K

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for POLR2K Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for POLR2K gene:
Search GeneIP for patents involving POLR2K

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for POLR2K  
 OriGene qPCR primer pairs and template standards for POLR2K   OriGene Protein Over-expression Lysate for POLR2K  
 OriGene MassSpec something-or-other for POLR2K   OriGene clones in human, mouse for POLR2K  
 Browse OriGene qSTAR qPCR primer pairs   OriGene Purified Protein for POLR2K  
 OriGene ORF clones in mouse, rat for POLR2K   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for POLR2K   OriGene Custom Protein Services for POLR2K  

 
 
 Block miRNA regulation of human, mouse, rat POLR2K using miScript Target Protectors SeqTarget long-range PCR primers for resequencing POLR2K
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POLR2K Predesigned siRNA for gene silencing in human, mouse, rat POLR2K
 Search QuantiFast Probe-based Assays in human, mouse, rat POLR2K QuantiTect SYBR Green Assays in human, mouse, rat POLR2K
 Custom PCR Arrays for POLR2K Search Chromatin IP Primers for POLR2K
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POLR2K  GeneGlobe Interaction Network for POLR2K
 Regulatory tfbs in POLR2K promoter
 GenScript Custom Purified and Recombinant Proteins Services for POLR2K GenScript cDNA clones with any tag delivered in your preferred vector for POLR2K
 GenScript Custom Assay Services for POLR2K GenScript Custom overexpressing Cell Line Services for POLR2K
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for POLR2K (RPAB4)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 POLR2K antibodies
 POLR2K proteins
 POLR2K lysates
 Antibodies for POLR2K
 See all of Abcam's Antibodies, Kits and Proteins for POLR2K
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for POLR2K
 Antibodies for POLR2K
 ELISAs for POLR2K
 CLIAs for POLR2K



 Browse ESI BIO Cell Lines and PureStem Progenitors for POLR2K
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2K
 SwitchGear 3'UTR luciferase reporter plasmids for POLR2K
 SwitchGear Promoter luciferase reporter plasmids for POLR2K
 ThermoFisher Antibodies for POLR2K
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR2K
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POLR2K
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for POLR2K
 LSBio Antibodies in human, mouse, rat for POLR2K
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for POLR2K
  Search eBioscience for proteins for POLR2K
  Search eBioscience for elisas for POLR2K
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      POLR2K gene at Home site.
Version: 3.12.212 17 Sep 2014
hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4