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Aliases for POLR2J2 Gene

Aliases for POLR2J2 Gene

  • Polymerase (RNA) II (DNA Directed) Polypeptide J2 2 3
  • DNA-Directed RNA Polymerase II Subunit J2 3 4
  • RNA Polymerase II Subunit B11-B1 3 4
  • RPB11b1 3 4
  • DNA Directed RNA Polymerase II Polypeptide J-Related 3
  • DNA-Directed RNA Polymerase II Subunit RPB11-B1 3
  • HRPB11B 3
  • RPB11 6

External Ids for POLR2J2 Gene

Summaries for POLR2J2 Gene

Entrez Gene Summary for POLR2J2 Gene

  • This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2J2 Gene

POLR2J2 (Polymerase (RNA) II (DNA Directed) Polypeptide J2) is a Protein Coding gene. Among its related pathways are Epstein-Barr virus infection and Metabolism. GO annotations related to this gene include protein dimerization activity and DNA-directed RNA polymerase activity. An important paralog of this gene is ENSG00000270249.

UniProtKB/Swiss-Prot for POLR2J2 Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).

Gene Wiki entry for POLR2J2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2J2 Gene

Genomics for POLR2J2 Gene

Genomic Location for POLR2J2 Gene

Start:
102,636,748 bp from pter
End:
102,671,729 bp from pter
Size:
34,982 bases
Orientation:
Minus strand

Genomic View for POLR2J2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POLR2J2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2J2 Gene

Regulatory Elements for POLR2J2 Gene

Proteins for POLR2J2 Gene

  • Protein details for POLR2J2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZM3-RPB1B_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB11-b1
    Protein Accession:
    Q9GZM3
    Secondary Accessions:
    • F6W009
    • Q9H1A8

    Protein attributes for POLR2J2 Gene

    Size:
    115 amino acids
    Molecular mass:
    13088 Da
    Quaternary structure:
    • Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits

    Alternative splice isoforms for POLR2J2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLR2J2 Gene

Proteomics data for POLR2J2 Gene at MOPED

Post-translational modifications for POLR2J2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys36, Lys46, Lys51, and Lys61

Other Protein References for POLR2J2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POLR2J2 Gene

Domains for POLR2J2 Gene

Gene Families for POLR2J2 Gene

HGNC:
  • POLR :RNA polymerase subunits

Protein Domains for POLR2J2 Gene

Suggested Antigen Peptide Sequences for POLR2J2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZM3

UniProtKB/Swiss-Prot:

RPB1B_HUMAN
Family:
  • Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.:
    • Q9GZM3
genes like me logo Genes that share domains with POLR2J2: view

Function for POLR2J2 Gene

Molecular function for POLR2J2 Gene

UniProtKB/Swiss-Prot Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).

Gene Ontology (GO) - Molecular Function for POLR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed RNA polymerase activity IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with POLR2J2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for POLR2J2 Gene

Localization for POLR2J2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2J2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR2J2 Gene COMPARTMENTS Subcellular localization image for POLR2J2 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for POLR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with POLR2J2: view

Pathways for POLR2J2 Gene

genes like me logo Genes that share pathways with POLR2J2: view

Interacting Proteins for POLR2J2 Gene

Gene Ontology (GO) - Biological Process for POLR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with POLR2J2: view

Transcripts for POLR2J2 Gene

mRNA/cDNA for POLR2J2 Gene

Unigene Clusters for POLR2J2 Gene

Polymerase (RNA) II (DNA directed) polypeptide J2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2J2 Gene

No ASD Table

Relevant External Links for POLR2J2 Gene

GeneLoc Exon Structure for
POLR2J2
ECgene alternative splicing isoforms for
POLR2J2

Expression for POLR2J2 Gene

mRNA expression in normal human tissues for POLR2J2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for POLR2J2 Gene Hs.732239

mRNA Expression by UniProt/SwissProt for POLR2J2 Gene

Q9GZM3-RPB1B_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with POLR2J2: view

No data available for mRNA differential expression in normal tissues and Protein expression for POLR2J2 Gene

Orthologs for POLR2J2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POLR2J2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 64 (a)
OneToMany
POLR2J2 35
  • 97.1 (n)
  • 95.65 (a)
cow
(Bos Taurus)
Mammalia POLR2J 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 79 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii polr2j 36
  • 85 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Rpb11 36
  • 70 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rpb-11 36
  • 59 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL005C 35
  • 58.18 (n)
  • 52.83 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB11 35
  • 58.49 (n)
  • 51.89 (a)
RPB11 36
  • 47 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C06160g 35
  • 56.29 (n)
  • 50.94 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb11 35
  • 51.6 (n)
  • 47.12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6583 36
  • 75 (a)
OneToMany
Species with no ortholog for POLR2J2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for POLR2J2 Gene

ENSEMBL:
Gene Tree for POLR2J2 (if available)
TreeFam:
Gene Tree for POLR2J2 (if available)

Paralogs for POLR2J2 Gene

Paralogs for POLR2J2 Gene

Selected SIMAP similar genes for POLR2J2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with POLR2J2: view

Variants for POLR2J2 Gene

Sequence variations from dbSNP and Humsavar for POLR2J2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs3864647 -- 102,646,233(-) cctgt(A/C)gtctc intron-variant
rs3988040 -- 102,667,120(-) ATCAG(C/G/T)GAGCT synonymous-codon, missense, reference
rs4729844 -- 102,646,876(+) agaga(A/G)agaga intron-variant
rs10275702 -- 102,671,888(+) GCGCC(A/G)GCAGG upstream-variant-2KB
rs10279075 -- 102,648,170(+) gttga(A/G)gcatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR2J2 Gene

Variant ID Type Subtype PubMed ID
nsv428182 CNV Gain 18775914
nsv831083 CNV Loss 17160897
dgv7412n71 CNV Loss 21882294
nsv5879 CNV Loss 18451855
nsv8192 CNV Gain 18304495
esv27624 CNV Gain+Loss 19812545
dgv7414n71 CNV Gain+Loss 21882294
dgv7415n71 CNV Gain+Loss 21882294
dgv7416n71 CNV Gain 21882294
dgv7417n71 CNV Gain 21882294
nsv888845 CNV Gain 21882294
dgv23n31 CNV Duplication 19718026
dgv7418n71 CNV Gain 21882294
nsv888865 CNV Loss 21882294
dgv7419n71 CNV Loss 21882294
dgv7420n71 CNV Gain 21882294
esv7079 CNV Loss 19470904
dgv7421n71 CNV Gain+Loss 21882294
nsv888872 CNV Gain+Loss 21882294
nsv469682 CNV Complex 16826518
nsv471643 CNV Gain+Loss 15918152
nsv509219 CNV Insertion 20534489
dgv7423n71 CNV Loss 21882294
nsv888877 CNV Loss 21882294
dgv7424n71 CNV Gain 21882294
dgv7425n71 CNV Loss 21882294
nsv9 CNV Loss 15895083
nsv499135 CNV Loss 21111241
dgv7427n71 CNV Gain+Loss 21882294
dgv7428n71 CNV Gain+Loss 21882294
dgv7429n71 CNV Loss 21882294
dgv7430n71 CNV Gain+Loss 21882294
dgv7431n71 CNV Loss 21882294
dgv7432n71 CNV Loss 21882294
nsv888907 CNV Gain+Loss 21882294
dgv7433n71 CNV Loss 21882294
dgv7435n71 CNV Gain 21882294
nsv888921 CNV Gain 21882294
nsv482113 CNV Gain 20164927
nsv469620 CNV Loss 16826518

Relevant External Links for POLR2J2 Gene

HapMap Linkage Disequilibrium report
POLR2J2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2J2 Gene

Disorders for POLR2J2 Gene

No disorders were found for POLR2J2 Gene.

No data available for UniProtKB/Swiss-Prot for POLR2J2 Gene

Publications for POLR2J2 Gene

  1. [New genes on human chromosome 7: bioinformatic analysis of a gene cluster from the POLR2J family]. (PMID: 15586814) ShpakovskiA- D.G. … ShpakovskiA- G.V. (Bioorg. Khim. 2004) 2 3
  2. A human RNA polymerase II subunit is encoded by a recently generated multigene family. (PMID: 11747469) Grandemange S. … Vigneron M. (BMC Mol. Biol. 2001) 3 4
  3. The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11. (PMID: 12036295) Durrin L.K. … Krontiris T.G. (Genomics 2002) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Levels of expression of hRPB11, a core subassembly subunit of human RNA polymerase II, affect doxorubicin sensitivity and cellular differentiation. (PMID: 9607319) Bruno T. … Fanciulli M. (FEBS Lett. 1998) 23

Products for POLR2J2 Gene

Sources for POLR2J2 Gene

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