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Aliases for POLR2J2 Gene

Aliases for POLR2J2 Gene

  • RNA Polymerase II Subunit J2 2 3 5
  • Polymerase (RNA) II (DNA Directed) Polypeptide J2 2 3
  • DNA-Directed RNA Polymerase II Subunit J2 3 4
  • RNA Polymerase II Subunit B11-B1 3 4
  • RPB11b1 3 4
  • DNA Directed RNA Polymerase II Polypeptide J-Related 3
  • DNA-Directed RNA Polymerase II Subunit RPB11-B1 3
  • Polymerase (RNA) II Subunit J2 3
  • HRPB11B 3

External Ids for POLR2J2 Gene

Previous GeneCards Identifiers for POLR2J2 Gene

  • GC07U990355
  • GC07M100764
  • GC07M101725
  • GC07M101841
  • GC07M101875
  • GC07M101772
  • GC07M102064
  • GC07M102278
  • GC07M043909
  • GC07M102280
  • GC07M102179
  • GC07M102282

Summaries for POLR2J2 Gene

Entrez Gene Summary for POLR2J2 Gene

  • This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2J2 Gene

POLR2J2 (RNA Polymerase II Subunit J2) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Purine metabolism (KEGG). GO annotations related to this gene include protein dimerization activity and DNA-directed 5-3 RNA polymerase activity. An important paralog of this gene is ENSG00000267645.

UniProtKB/Swiss-Prot for POLR2J2 Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).

Gene Wiki entry for POLR2J2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2J2 Gene

Genomics for POLR2J2 Gene

Regulatory Elements for POLR2J2 Gene

Enhancers for POLR2J2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G102713 1.3 Ensembl ENCODE dbSUPER 30.6 -42.9 -42899 3.3 CTCF FEZF1 BMI1 ZBTB40 ARID3A ZNF143 PRDM10 RELB IKZF2 ZNF263 POLR2J2 RASA4 RASA4DP FAM185A
GH07G102748 1.1 ENCODE 28.8 -77.4 -77357 1.7 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143 POLR2J2 RASA4DP RASA4 ARMC10 FBXL13 POLR2J FAM185A RPL7AP39
GH07G102451 1.4 Ensembl ENCODE dbSUPER 10.7 +220.0 220042 0.9 HDAC1 RB1 CREB3L1 AGO1 ARID4B RAD21 KLF13 THAP11 SP5 REST ORAI2 POLR2J2 POLR2J PIR32382 ENSG00000239480
GH07G102572 1.1 ENCODE 9.4 +99.0 99049 1.2 ARNT CREB3L1 SIN3A FEZF1 ZNF2 ZNF416 ZNF143 ZNF207 SP3 REST CRYZP1 ENSG00000213385 FAM185A PMPCB UPK3BL1 POLR2J2 POLR2J3 LOC102724229
GH07G102061 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5 +607.7 607746 5.7 HDGF PKNOX1 WRNIP1 SIN3A BRCA1 ZNF121 GLIS2 ZNF143 ZNF207 DEK POLR2J2 SH2B2 CUX1 ORAI2 GC07P102081 GC07M102004
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLR2J2 on UCSC Golden Path with GeneCards custom track

Promoters for POLR2J2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000216134 329 1201 CTCF RB1 SIN3A ZBTB40 ZNF366 POLR2A EGR1 NFE2 ZBTB2 NRF1

Genomic Location for POLR2J2 Gene

Chromosome:
7
Start:
102,636,748 bp from pter
End:
102,671,729 bp from pter
Size:
34,982 bases
Orientation:
Minus strand

Genomic View for POLR2J2 Gene

Genes around POLR2J2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2J2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2J2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2J2 Gene

Proteins for POLR2J2 Gene

  • Protein details for POLR2J2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZM3-RPB1B_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB11-b1
    Protein Accession:
    Q9GZM3
    Secondary Accessions:
    • F6W009
    • Q9H1A8

    Protein attributes for POLR2J2 Gene

    Size:
    115 amino acids
    Molecular mass:
    13088 Da
    Quaternary structure:
    • Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.

    Alternative splice isoforms for POLR2J2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLR2J2 Gene

Post-translational modifications for POLR2J2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POLR2J2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POLR2J2 Gene

Domains & Families for POLR2J2 Gene

Gene Families for POLR2J2 Gene

Suggested Antigen Peptide Sequences for POLR2J2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZM3

UniProtKB/Swiss-Prot:

RPB1B_HUMAN :
  • Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
Family:
  • Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2J2: view

Function for POLR2J2 Gene

Molecular function for POLR2J2 Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).

Gene Ontology (GO) - Molecular Function for POLR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001055 contributes_to RNA polymerase II activity IBA --
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed 5-3 RNA polymerase activity IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with POLR2J2: view
genes like me logo Genes that share phenotypes with POLR2J2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POLR2J2 Gene

Localization for POLR2J2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2J2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR2J2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for POLR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005665 DNA-directed RNA polymerase II, core complex IBA --
genes like me logo Genes that share ontologies with POLR2J2: view

Pathways & Interactions for POLR2J2 Gene

genes like me logo Genes that share pathways with POLR2J2: view

Interacting Proteins for POLR2J2 Gene

Selected Interacting proteins: Q9GZM3-RPB1B_HUMAN for POLR2J2 Gene via IID

Gene Ontology (GO) - Biological Process for POLR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with POLR2J2: view

No data available for SIGNOR curated interactions for POLR2J2 Gene

Drugs & Compounds for POLR2J2 Gene

(4) Drugs for POLR2J2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0

(1) Additional Compounds for POLR2J2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with POLR2J2: view

Transcripts for POLR2J2 Gene

mRNA/cDNA for POLR2J2 Gene

Unigene Clusters for POLR2J2 Gene

Polymerase (RNA) II (DNA directed) polypeptide J2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2J2 Gene

No ASD Table

Relevant External Links for POLR2J2 Gene

GeneLoc Exon Structure for
POLR2J2
ECgene alternative splicing isoforms for
POLR2J2

Expression for POLR2J2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR2J2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of POLR2J2 Gene:

POLR2J2

SOURCE GeneReport for Unigene cluster for POLR2J2 Gene:

Hs.732239

mRNA Expression by UniProt/SwissProt for POLR2J2 Gene:

Q9GZM3-RPB1B_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for POLR2J2 Gene

  • Lung(4)
genes like me logo Genes that share expression patterns with POLR2J2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR2J2 Gene

Orthologs for POLR2J2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POLR2J2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR2J2 34
  • 97.1 (n)
-- 35
  • 64 (a)
OneToMany
cow
(Bos Taurus)
Mammalia POLR2J 35
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 81 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 80 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 79 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii polr2j 35
  • 85 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Rpb11 35
  • 70 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rpb-11 35
  • 59 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB11 34 35
  • 58.49 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL005C 34
  • 58.18 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C06160g 34
  • 56.29 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6583 35
  • 75 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb11 34
  • 51.6 (n)
Species where no ortholog for POLR2J2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for POLR2J2 Gene

ENSEMBL:
Gene Tree for POLR2J2 (if available)
TreeFam:
Gene Tree for POLR2J2 (if available)

Paralogs for POLR2J2 Gene

Paralogs for POLR2J2 Gene

(9) SIMAP similar genes for POLR2J2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with POLR2J2: view

Variants for POLR2J2 Gene

Sequence variations from dbSNP and Humsavar for POLR2J2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1006631316 -- 102,666,314(+) GGTCC(C/G)TCCCA intron-variant
rs1009680804 -- 102,646,923(+) AGAAA(A/G)GAAAG intron-variant
rs1016857944 -- 102,647,273(+) GGCAT(C/G)AGCCA intron-variant
rs1017049229 -- 102,666,375(+) TGAAC(C/T)ATGTC intron-variant
rs10255511 -- 102,644,584(+) ATTAG(C/T)CAGTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for POLR2J2 Gene

Variant ID Type Subtype PubMed ID
dgv11541n54 CNV loss 21841781
dgv11542n54 CNV loss 21841781
dgv11543n54 CNV loss 21841781
dgv11544n54 CNV loss 21841781
dgv11547n54 CNV loss 21841781
dgv11548n54 CNV loss 21841781
dgv11550n54 CNV loss 21841781
dgv1944e212 CNV loss 25503493
dgv23n31 CNV gain 19718026
dgv3894e59 CNV duplication 20981092
dgv3904e59 CNV duplication 20981092
dgv3906e59 CNV duplication 20981092
dgv3907e59 CNV duplication 20981092
dgv6538n100 CNV gain 25217958
dgv6539n100 CNV gain 25217958
dgv6540n100 CNV gain 25217958
dgv6541n100 CNV gain 25217958
esv27624 CNV gain+loss 19812545
esv2764015 CNV loss 21179565
esv3322158 CNV duplication 20981092
esv3343524 CNV duplication 20981092
esv3353259 CNV duplication 20981092
esv3377591 CNV duplication 20981092
esv3413878 CNV duplication 20981092
esv3424897 CNV duplication 20981092
esv3891168 CNV gain+loss 25118596
esv3891171 CNV loss 25118596
esv7079 CNV loss 19470904
nsv1027221 CNV loss 25217958
nsv1034233 CNV loss 25217958
nsv1110496 CNV duplication 24896259
nsv1119231 CNV duplication 24896259
nsv1128957 CNV duplication 24896259
nsv1139905 CNV duplication 24896259
nsv1153617 CNV duplication 26484159
nsv428182 CNV gain 18775914
nsv469620 CNV loss 16826518
nsv469682 CNV gain+loss 16826518
nsv471643 CNV gain+loss 15918152
nsv482113 CNV gain 20164927
nsv499135 CNV loss 21111241
nsv509219 CNV insertion 20534489
nsv5879 CNV deletion 18451855
nsv608005 CNV gain 21841781
nsv608046 CNV loss 21841781
nsv608048 CNV loss 21841781
nsv608054 CNV loss 21841781
nsv608055 CNV gain 21841781
nsv8192 CNV gain 18304495
nsv831083 CNV loss 17160897
nsv9 CNV deletion 15895083
nsv966868 CNV duplication 23825009
nsv970563 CNV duplication 23825009
nsv981563 CNV duplication 23825009

Variation tolerance for POLR2J2 Gene

Gene Damage Index Score: 0.72; 15.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR2J2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR2J2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2J2 Gene

Disorders for POLR2J2 Gene

Relevant External Links for POLR2J2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2J2

No disorders were found for POLR2J2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR2J2 Gene

Publications for POLR2J2 Gene

  1. [New genes on human chromosome 7: bioinformatic analysis of a gene cluster from the POLR2J family]. (PMID: 15586814) ShpakovskiA- D.G. … ShpakovskiA- G.V. (Bioorg. Khim. 2004) 2 3 64
  2. The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11. (PMID: 12036295) Durrin L.K. … Krontiris T.G. (Genomics 2002) 3 4 64
  3. A human RNA polymerase II subunit is encoded by a recently generated multigene family. (PMID: 11747469) Grandemange S. … Vigneron M. (BMC Mol. Biol. 2001) 3 4 64
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3 64
  5. Human PMS2 gene family: origin, molecular evolution, and biological implications. (PMID: 16913423) Shpakovskii D.G. … Shpakovskii G.V. (Dokl. Biochem. Biophys. 2006) 3 64

Products for POLR2J2 Gene

Sources for POLR2J2 Gene

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