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Aliases for POLR2J2 Gene

Aliases for POLR2J2 Gene

  • Polymerase (RNA) II Subunit J2 2 3
  • Polymerase (RNA) II (DNA Directed) Polypeptide J2 2 3 5
  • DNA-Directed RNA Polymerase II Subunit J2 3 4
  • RNA Polymerase II Subunit B11-B1 3 4
  • RPB11b1 3 4
  • DNA Directed RNA Polymerase II Polypeptide J-Related 3
  • HRPB11B 3

External Ids for POLR2J2 Gene

Previous GeneCards Identifiers for POLR2J2 Gene

  • GC07U990355
  • GC07M100764
  • GC07M101725
  • GC07M101841
  • GC07M101875
  • GC07M101772
  • GC07M102064
  • GC07M102278
  • GC07M043909
  • GC07M102280
  • GC07M102179
  • GC07M102282

Summaries for POLR2J2 Gene

Entrez Gene Summary for POLR2J2 Gene

  • This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2J2 Gene

POLR2J2 (Polymerase (RNA) II Subunit J2) is a Protein Coding gene. Among its related pathways are Metabolism and Pyrimidine metabolism (KEGG). GO annotations related to this gene include protein dimerization activity and DNA-directed RNA polymerase activity. An important paralog of this gene is ENSG00000270249.

UniProtKB/Swiss-Prot for POLR2J2 Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).

Gene Wiki entry for POLR2J2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2J2 Gene

Genomics for POLR2J2 Gene

Regulatory Elements for POLR2J2 Gene

Promoters for POLR2J2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POLR2J2 on UCSC Golden Path with GeneCards custom track

Genomic Location for POLR2J2 Gene

Chromosome:
7
Start:
102,636,748 bp from pter
End:
102,671,729 bp from pter
Size:
34,982 bases
Orientation:
Minus strand

Genomic View for POLR2J2 Gene

Genes around POLR2J2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2J2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2J2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2J2 Gene

Proteins for POLR2J2 Gene

  • Protein details for POLR2J2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZM3-RPB1B_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB11-b1
    Protein Accession:
    Q9GZM3
    Secondary Accessions:
    • F6W009
    • Q9H1A8

    Protein attributes for POLR2J2 Gene

    Size:
    115 amino acids
    Molecular mass:
    13088 Da
    Quaternary structure:
    • Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.

    Alternative splice isoforms for POLR2J2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLR2J2 Gene

Proteomics data for POLR2J2 Gene at MOPED

Post-translational modifications for POLR2J2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POLR2J2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POLR2J2 Gene

Domains & Families for POLR2J2 Gene

Gene Families for POLR2J2 Gene

Protein Domains for POLR2J2 Gene

Suggested Antigen Peptide Sequences for POLR2J2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZM3

UniProtKB/Swiss-Prot:

RPB1B_HUMAN :
  • Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
Family:
  • Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2J2: view

Function for POLR2J2 Gene

Molecular function for POLR2J2 Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).

Gene Ontology (GO) - Molecular Function for POLR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001055 contributes_to RNA polymerase II activity IBA --
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed RNA polymerase activity IEA --
genes like me logo Genes that share ontologies with POLR2J2: view
genes like me logo Genes that share phenotypes with POLR2J2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POLR2J2 Gene

Localization for POLR2J2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2J2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR2J2 Gene COMPARTMENTS Subcellular localization image for POLR2J2 gene
Compartment Confidence
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for POLR2J2 Gene

Pathways & Interactions for POLR2J2 Gene

genes like me logo Genes that share pathways with POLR2J2: view

Interacting Proteins for POLR2J2 Gene

Gene Ontology (GO) - Biological Process for POLR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with POLR2J2: view

No data available for SIGNOR curated interactions for POLR2J2 Gene

Drugs & Compounds for POLR2J2 Gene

(5) Drugs for POLR2J2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with POLR2J2: view

Transcripts for POLR2J2 Gene

mRNA/cDNA for POLR2J2 Gene

Unigene Clusters for POLR2J2 Gene

Polymerase (RNA) II (DNA directed) polypeptide J2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2J2 Gene

No ASD Table

Relevant External Links for POLR2J2 Gene

GeneLoc Exon Structure for
POLR2J2
ECgene alternative splicing isoforms for
POLR2J2

Expression for POLR2J2 Gene

mRNA expression in normal human tissues for POLR2J2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for POLR2J2 Gene Hs.732239

mRNA Expression by UniProt/SwissProt for POLR2J2 Gene

Q9GZM3-RPB1B_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with POLR2J2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for POLR2J2 Gene

Orthologs for POLR2J2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POLR2J2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR2J2 35
  • 97.1 (n)
  • 95.65 (a)
-- 36
  • 64 (a)
OneToMany
cow
(Bos Taurus)
Mammalia POLR2J 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 79 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii polr2j 36
  • 85 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Rpb11 36
  • 70 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rpb-11 36
  • 59 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL005C 35
  • 58.18 (n)
  • 52.83 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C06160g 35
  • 56.29 (n)
  • 50.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB11 35
  • 58.49 (n)
  • 51.89 (a)
RPB11 36
  • 47 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb11 35
  • 51.6 (n)
  • 47.12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6583 36
  • 75 (a)
OneToMany
Species with no ortholog for POLR2J2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for POLR2J2 Gene

ENSEMBL:
Gene Tree for POLR2J2 (if available)
TreeFam:
Gene Tree for POLR2J2 (if available)

Paralogs for POLR2J2 Gene

Paralogs for POLR2J2 Gene

(9) SIMAP similar genes for POLR2J2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with POLR2J2: view

Variants for POLR2J2 Gene

Sequence variations from dbSNP and Humsavar for POLR2J2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_070807 -
rs1140997 -- 102,665,356(-) taaaa(A/C)aaaag intron-variant
rs2522933 -- 102,647,392(-) TGAGC(A/G)GGGCC intron-variant
rs3864647 -- 102,646,233(-) cctgt(A/C)gtctc intron-variant
rs3988020 -- 102,663,949(-) aaaat(A/T)caaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR2J2 Gene

Variant ID Type Subtype PubMed ID
nsv428182 CNV Gain 18775914
nsv831083 CNV Loss 17160897
dgv7412n71 CNV Loss 21882294
nsv5879 CNV Loss 18451855
nsv8192 CNV Gain 18304495
esv27624 CNV Gain+Loss 19812545
dgv7414n71 CNV Gain+Loss 21882294
dgv7415n71 CNV Gain+Loss 21882294
dgv7416n71 CNV Gain 21882294
dgv7417n71 CNV Gain 21882294
nsv888845 CNV Gain 21882294
dgv23n31 CNV Duplication 19718026
dgv7418n71 CNV Gain 21882294
nsv888865 CNV Loss 21882294
dgv7419n71 CNV Loss 21882294
dgv7420n71 CNV Gain 21882294
esv7079 CNV Loss 19470904
dgv7421n71 CNV Gain+Loss 21882294
nsv888872 CNV Gain+Loss 21882294
nsv469682 CNV Complex 16826518
nsv471643 CNV Gain+Loss 15918152
nsv509219 CNV Insertion 20534489
dgv7423n71 CNV Loss 21882294
nsv888877 CNV Loss 21882294
dgv7424n71 CNV Gain 21882294
dgv7425n71 CNV Loss 21882294
nsv9 CNV Loss 15895083
nsv499135 CNV Loss 21111241
dgv7427n71 CNV Gain+Loss 21882294
dgv7428n71 CNV Gain+Loss 21882294
dgv7429n71 CNV Loss 21882294
dgv7430n71 CNV Gain+Loss 21882294
dgv7431n71 CNV Loss 21882294
dgv7432n71 CNV Loss 21882294
nsv888907 CNV Gain+Loss 21882294
dgv7433n71 CNV Loss 21882294
dgv7435n71 CNV Gain 21882294
nsv888921 CNV Gain 21882294
nsv482113 CNV Gain 20164927
nsv469620 CNV Loss 16826518

Variation tolerance for POLR2J2 Gene

Gene Damage Index Score: 0.72; 15.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR2J2 Gene

HapMap Linkage Disequilibrium report
POLR2J2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2J2 Gene

Disorders for POLR2J2 Gene

Relevant External Links for POLR2J2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2J2

No disorders were found for POLR2J2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR2J2 Gene

Publications for POLR2J2 Gene

  1. [New genes on human chromosome 7: bioinformatic analysis of a gene cluster from the POLR2J family]. (PMID: 15586814) ShpakovskiA- D.G. … ShpakovskiA- G.V. (Bioorg. Khim. 2004) 2 3 67
  2. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3
  3. Human PMS2 gene family: origin, molecular evolution, and biological implications. (PMID: 16913423) Shpakovskii D.G. … Shpakovskii G.V. (Dokl. Biochem. Biophys. 2006) 3
  4. Distinct regions of RPB11 are required for heterodimerization with RPB3 in human and yeast RNA polymerase II. (PMID: 15987790) Benga W.J. … Vigneron M. (Nucleic Acids Res. 2005) 3
  5. The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11. (PMID: 12036295) Durrin L.K. … Krontiris T.G. (Genomics 2002) 3

Products for POLR2J2 Gene

Sources for POLR2J2 Gene

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