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POLR2J Gene

protein-coding   GIFtS: 62
GCID: GC07M102113

Polymerase (RNA) II (DNA Directed) Polypeptide J, 13.3kDa

(Previous name: polymerase (RNA) II (DNA directed) polypeptide J (13.3kD))
  See POLR2J-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Polymerase (RNA) II (DNA Directed) Polypeptide J, 13.3kDa1 2     RPB112
POLR2J12 3     RPB11A2
DNA-Directed RNA Polymerase II Subunit J-12 3     RPB11m2
RNA Polymerase II 13.3 KDa Subunit2 3     DNA-Directed RNA Polymerase II Subunit RPB11-A2
RNA Polymerase II Subunit B11-A2 3     hRPB142
Polymerase (RNA) II (DNA Directed) Polypeptide J (13.3kD)1     RPB11a3

External Ids:    HGNC: 91971   Entrez Gene: 54392   Ensembl: ENSG000000050757   OMIM: 6041505   UniProtKB: P524353   

Export aliases for POLR2J gene to outside databases

Previous GC identifers: GC07M100597 GC07M101660 GC07M101674 GC07M101707 GC07M101900 GC07M096703


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POLR2J Gene:
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in
eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form
a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a
pseudogene is found on chromosome 7p13. (provided by RefSeq, Jul 2008)

GeneCards Summary for POLR2J Gene:
POLR2J (polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa) is a protein-coding gene. Diseases associated with POLR2J include hiv-1. GO annotations related to this gene include RNA polymerase II activity and protein dimerization activity. An important paralog of this gene is POLR2J2.

UniProtKB/Swiss-Prot: RPB11_HUMAN, P52435
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional
non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is
composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central
large cleft (By similarity)

Gene Wiki entry for POLR2J Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the POLR2J gene promoter:
         c-Fos   AML1a   AP-1   Pax-5   GCNF   CUTL1   E47   GCNF-1   c-Jun   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOLR2J promoter sequence
   Search Chromatin IP Primers for POLR2J

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POLR2J


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q11.2

POLR2J Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR2J gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M102113:  view genomic region     (about GC identifiers)

Start:
102,113,547 bp from pter      End:
102,119,381 bp from pter
Size:
5,835 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 101,473,848-101,479,682     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RPB11_HUMAN, P52435 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase II subunit RPB11-a  
Size: 117 amino acids; 13293 Da
Subunit: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. Interacts with AATF
Secondary accessions: A5D6V8 O43375

Explore the universe of human proteins at neXtProt for POLR2J: NX_P52435

Explore proteomics data for POLR2J at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys37, Lys47, Lys52, Lys62
  • Modification sites at PhosphoSitePlus

  • See POLR2J Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006225.1  
    ENSEMBL proteins: 
     ENSP00000292614   ENSP00000377383  
    Reactome Protein details: P52435

    POLR2J Human Recombinant Protein Products:

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    antibodies-online proteins for POLR2J (3 products) 

     
    antibodies-online peptides for POLR2J

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POLR: RNA polymerase subunits

    2 InterPro protein domains:
     IPR008193 RNA_pol_Rpb11_13-16kDa_CS
     IPR009025 RBP11-like_dimer

    Graphical View of Domain Structure for InterPro Entry P52435

    ProtoNet protein and cluster: P52435

    1 Blocks protein domain: IPB008193 DNA-directed RNA polymerase

    UniProtKB/Swiss-Prot: RPB11_HUMAN, P52435
    Similarity: Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family


    Find genes that share domains with POLR2J           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPB11_HUMAN, P52435
    Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
    triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional
    non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is
    composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central
    large cleft (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001055contributes to RNA polymerase II activity IBA--
    GO:0003677DNA binding IEA--
    GO:0003899DNA-directed RNA polymerase activity TAS8797801
    GO:0005515protein binding IPI10783144
    GO:0030275LRR domain binding IPI10783144
         
    Find genes that share ontologies with POLR2J           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for POLR2J:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for POLR2J

    miRNA
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    miRTarBase miRNAs that target POLR2J:
    hsa-mir-124-3p (MIRT022854)

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    2 qRT-PCR Assays for microRNAs that regulate POLR2J:
    hsa-let-7g* hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmidPOLR2J 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RPB11_HUMAN, P52435: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9852112
    GO:0005654nucleoplasm TAS--
    GO:0005665DNA-directed RNA polymerase II, core complex IDA9852112

    Find genes that share ontologies with POLR2J           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POLR2J About   (see all 15)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    mRNA Capping0.93
    Pausing and recovery of Tat-mediated HIV elongation0.72
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Tat-mediated HIV elongation arrest and recovery0.72
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Transcription of the HIV genome0.71
    Formation of the Early Elongation Complex0.77
    Abortive elongation of HIV-1 transcript in the absence of Tat0.70
    2Purine metabolism (KEGG)
    Purine metabolism0.38
    ATP ITP metabolism0.31
    Pyrimidine metabolism0.38
    3DNA Repair
    Transcription-coupled NER (TC-NER)0.90
    Formation of transcription-coupled NER (TC-NER) repair complex0.65
    Nucleotide Excision Repair0.90
    DNA Repair0.45
    Dual incision reaction in TC-NER0.65
    4mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA Splicing - Minor Pathway0.38
    5HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91


    Find genes that share SuperPaths with POLR2J           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for POLR2J
        DNA damage Role of Brca1 and Brca2 in DNA repair
    ATP/ITP metabolism
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for POLR2J
        Eukaryotic Transcription Initiation

    Selected Reactome Pathways for POLR2J (see all 31)
        Pausing and recovery of Tat-mediated HIV elongation
    Tat-mediated HIV elongation arrest and recovery
    Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript
    RNA Polymerase II Transcription Initiation And Promoter Clearance


    Selected Kegg Pathways  (Kegg details for POLR2J) (see all 6):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways
    RNA polymerase
    Huntington's disease

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POLR2J
    Interactions:

        Search GeneGlobe Interaction Network for POLR2J

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for POLR2J (P524352, 3 ENSP000002926144) via UniProtKB, MINT, STRING, and/or I2D (see all 138)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AATFQ9NY612, 3, ENSP000002254024MINT-49955 MINT-49956 I2D: score=4 STRING: ENSP00000225402
    POLR2GP624873, ENSP000003017884I2D: score=7 STRING: ENSP00000301788
    POLR2EP193883, ENSP000002155874I2D: score=6 STRING: ENSP00000215587
    POLR2IP369543, ENSP000002218594I2D: score=4 STRING: ENSP00000221859
    MED10Q9BTT43, ENSP000002557644I2D: score=2 STRING: ENSP00000255764
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006281DNA repair TAS--
    GO:0006283transcription-coupled nucleotide-excision repair TAS--
    GO:0006289nucleotide-excision repair TAS--
    GO:0006351transcription, DNA-templated ----

    Find genes that share ontologies with POLR2J           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POLR2J (RPB11)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for POLR2J gene: 
    NM_006234.4  

    Unigene Cluster for POLR2J:

    Polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
    Hs.654952  [show with all ESTs]
    Unigene Representative Sequence: BM910996
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000292614(uc003uzp.1) ENST00000393794
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidPOLR2J 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat POLR2J
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    Additional mRNA sequence: 

    AK290515.1 BC024165.1 BC040116.1 BC065711.1 BC139902.1 BC141830.1 L37127.1 X82385.1 
    X98433.1 

    Selected DOTS entries (see all 31):

    DT.97864593  DT.102840205  DT.92036316  DT.121040146  DT.121040127  DT.121040275  DT.92405417  DT.111585 
    DT.121040332  DT.92330191  DT.454971  DT.99964099  DT.100824847  DT.102840197  DT.87077954  DT.428752 
    DT.428770  DT.92461428  DT.100761235  DT.100762651  DT.121040077  DT.121040935  DT.121041135  DT.91711277 

    Selected AceView cDNA sequences (see all 91):

    BU782839 D19649 BC040116 BM724873 BM825109 AI200697 AA838756 BM716021 
    AI633202 AA937330 NM_006234 CB117785 BC065711 BI710894 AA814184 R96453 
    CB107230 BE891205 AI453585 BM974544 BI836424 BU741502 BI752508 BU781939 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    POLR2J expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCGCCTTG
    POLR2J Expression
    About this image


    POLR2J expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Telencephalon
    POLR2J Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POLR2J Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654952

    UniProtKB/Swiss-Prot: RPB11_HUMAN, P52435
    Tissue specificity: Ubiquitously expressed. High expression was found in heart and skeletal muscle

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2J

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for POLR2J gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Polr2j1 , 5 polymerase (RNA) II (DNA directed) polypeptide J1, 5 89.74(n)1
    100(a)1
      5 (75.80 cM)5
    200221  NM_011293.21  NP_035423.21 
     1361166315 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    91(a)
    1 → many
    GL343653.1(72885-73238)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.55442 Xenopus laevis transcribed sequence with strong similarity more 78.53(n)    48031839 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.179972 Transcribed sequence with strong similarity to protein more 81.62(n)    BQ615199.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rpb111 , 3 transcription from Pol II promoter
    DNA-directed more3
    Rpb111
    78(a)3
    70.14(n)1
    78.26(a)1
      36C73
    350431  NM_135992.41  NP_609836.11 
    worm
    (Caenorhabditis elegans)
    Secernentea W01G7.33
    rpb-111
    RNA polymerases L / 13 to 16 Kd subunit3
    rpb-111
    70(a)3
    66.97(n)1
    70.64(a)1
      II(14059647-14060450)3
    1750561  NM_064541.31  NP_496942.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPB116
    RNA polymerase II subunit B12.5; part of central c...
    46(a)
    1 → many
    XV(315813-316175) YOL005C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NRPB111 NRPB11 55.96(n)
    49.54(a)
      824372  NM_115068.4  NP_190777.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g01725001 Os07g0172500 56.51(n)
    53.33(a)
      4342517  NM_001065533.1  NP_001058998.1 


    ENSEMBL Gene Tree for POLR2J (if available)
    TreeFam Gene Tree for POLR2J (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for POLR2J gene
    POLR2J22  POLR2J32  ENSG000002702492  
    4 SIMAP similar genes for POLR2J using alignment to 1 protein entry:     RPB11_HUMAN:
    POLR2J2    POLR2J3    POLR2J1    POLR1D

    Find genes that share paralogs with POLR2J           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POLR2J (see all 116)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1396403351,2
    --102114148(+) GAAGGG/TGGTGG 1 -- int10--------
    rs751065201,2
    C,F--102114151(+) GGTGGT/AGGAGA 1 -- int14Minor allele frequency- A:0.06NA WA EU 1486
    rs3701203471,2
    C--102114206(+) CAGCA-/CCCCCC 1 -- int10--------
    rs1132684161,2
    C--102114304(+) GCCATT/CCTCTA 1 -- int12Minor allele frequency- C:0.10CSA WA 120
    rs1171653831,2
    C,F--102114309(+) TCTCTA/GTGGCA 1 -- int11Minor allele frequency- G:0.02NA 120
    rs1831431971,2
    --102114316(+) GGCAGC/TCCCGG 1 -- int10--------
    rs1164455531,2
    F--102114378(+) GAAATC/ACCCCA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1874749221,2
    --102114405(+) CCTCTA/CAACTG 1 -- int10--------
    rs96921241,2
    C,A--102114424(+) TCCCAG/TGCGCC 1 -- int14Minor allele frequency- T:0.00NA CSA 7
    rs1427629391,2
    C--102114441(+) GGAACA/TGGTGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for POLR2J (102113547 - 102119381 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for POLR2J (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv23n31CNV Duplication19718026
    nsv471450CNV Duplication19718026
    nsv5879CNV Loss18451855
    dgv7412n71CNV Loss21882294
    nsv888836CNV Loss21882294
    nsv888832CNV Loss21882294
    nsv831083CNV Loss17160897
    nsv464665CNV Loss19166990
    nsv464664CNV Gain19166990
    nsv428182CNV Gain18775914

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing POLR2J
    DNA2.0 Custom Variant and Variant Library Synthesis for POLR2J

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604150    OMIM disorders: --

    1 disease for POLR2J:    
    About MalaCards
    hiv-1


    Find genes that share disorders with POLR2J           About GenesLikeMe

    Genetic Association Database (GAD): POLR2J
    Human Genome Epidemiology (HuGE) Navigator: POLR2J (1 document)

    Export disorders for POLR2J gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POLR2J gene, integrated from 10 sources (see all 113):
    (articles sorted by number of sources associating them with POLR2J)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (Carcinogenesis 2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    4. Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb. (PubMed id 10783144)1, 2 Fanciulli M.... Passananti C. (FASEB J. 2000)
    5. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PubMed id 9852112)1, 2 Kershnar E.... Chiang C.-M. (J. Biol. Chem. 1998)
    6. Interactions between the human RNA polymerase II subunits. (PubMed id 9201987)1, 2 Acker J....Vigneron M. (J. Biol. Chem. 1997)
    7. Cloning of a novel human RNA polymerase II subunit downregulated by doxorubicin: new potential mechanisms of drug related toxicity. (PubMed id 8797801)1, 2 Fanciulli M.... Punturieri A. (FEBS Lett. 1996)
    8. A human RNA polymerase II subunit is encoded by a recently generated multigene family. (PubMed id 11747469)2, 9 Grandemange S.... Vigneron M. (BMC Mol. Biol. 2001)
    9. [New genes on human chromosome 7: bioinformatic analysis of a gene cluster from the POLR2J family]. (PubMed id 15586814)1, 9 ShpakovskiA- D.G....ShpakovskiA- G.V. (Bioorg. Khim. 2004)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5439 HGNC: 9197 AceView: POLR2J Ensembl:ENSG00000005075 euGenes: HUgn5439
    ECgene: POLR2J Kegg: 5439 H-InvDB: POLR2J

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for POLR2J Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for POLR2J gene:
    Search GeneIP for patents involving POLR2J

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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