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Aliases for POLR2J Gene

Aliases for POLR2J Gene

  • Polymerase (RNA) II Subunit J 2 3
  • Polymerase (RNA) II (DNA Directed) Polypeptide J, 13.3kDa 3 5
  • DNA-Directed RNA Polymerase II Subunit J-1 3 4
  • RNA Polymerase II 13.3 KDa Subunit 3 4
  • RNA Polymerase II Subunit B11-A 3 4
  • POLR2J1 3 4
  • RPB11A 3 4
  • Polymerase (RNA) II (DNA Directed) Polypeptide J (13.3kD) 2
  • RPB11m 3
  • HRPB14 3
  • RPB11 3

External Ids for POLR2J Gene

Previous GeneCards Identifiers for POLR2J Gene

  • GC07M100597
  • GC07M101660
  • GC07M101674
  • GC07M101707
  • GC07M101900
  • GC07M102113
  • GC07M096703

Summaries for POLR2J Gene

Entrez Gene Summary for POLR2J Gene

  • This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2J Gene

POLR2J (Polymerase (RNA) II Subunit J) is a Protein Coding gene. Diseases associated with POLR2J include hiv-1. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include protein dimerization activity and RNA polymerase II activity. An important paralog of this gene is ENSG00000270249.

UniProtKB/Swiss-Prot for POLR2J Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).

Gene Wiki entry for POLR2J Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2J Gene

Genomics for POLR2J Gene

Regulatory Elements for POLR2J Gene

Promoters for POLR2J Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POLR2J on UCSC Golden Path with GeneCards custom track

Genomic Location for POLR2J Gene

Chromosome:
7
Start:
102,473,100 bp from pter
End:
102,478,999 bp from pter
Size:
5,900 bases
Orientation:
Minus strand

Genomic View for POLR2J Gene

Genes around POLR2J on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2J Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2J Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2J Gene

Proteins for POLR2J Gene

  • Protein details for POLR2J Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52435-RPB11_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB11-a
    Protein Accession:
    P52435
    Secondary Accessions:
    • A5D6V8
    • O43375

    Protein attributes for POLR2J Gene

    Size:
    117 amino acids
    Molecular mass:
    13293 Da
    Quaternary structure:
    • Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. Interacts with AATF.

neXtProt entry for POLR2J Gene

Proteomics data for POLR2J Gene at MOPED

Post-translational modifications for POLR2J Gene

  • Ubiquitination at Lys 37
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR2J Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for POLR2J Gene

Domains & Families for POLR2J Gene

Gene Families for POLR2J Gene

Protein Domains for POLR2J Gene

Suggested Antigen Peptide Sequences for POLR2J Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52435

UniProtKB/Swiss-Prot:

RPB11_HUMAN :
  • Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
Family:
  • Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2J: view

Function for POLR2J Gene

Molecular function for POLR2J Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).

Gene Ontology (GO) - Molecular Function for POLR2J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003899 DNA-directed RNA polymerase activity IEA,TAS 8797801
genes like me logo Genes that share ontologies with POLR2J: view
genes like me logo Genes that share phenotypes with POLR2J: view

Animal Model Products

miRNA for POLR2J Gene

miRTarBase miRNAs that target POLR2J

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2J Gene

Localization for POLR2J Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2J Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR2J Gene COMPARTMENTS Subcellular localization image for POLR2J gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for POLR2J Gene

Pathways & Interactions for POLR2J Gene

SuperPathways for POLR2J Gene

Superpath Contained pathways
1 Formation of the HIV-1 Early Elongation Complex
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
4 mRNA Splicing - Major Pathway
5 Signaling by FGFR2 in disease
genes like me logo Genes that share pathways with POLR2J: view

Gene Ontology (GO) - Biological Process for POLR2J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006370 7-methylguanosine mRNA capping TAS --
genes like me logo Genes that share ontologies with POLR2J: view

No data available for SIGNOR curated interactions for POLR2J Gene

Drugs & Compounds for POLR2J Gene

(5) Drugs for POLR2J Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with POLR2J: view

Transcripts for POLR2J Gene

mRNA/cDNA for POLR2J Gene

Unigene Clusters for POLR2J Gene

Polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2J Gene

No ASD Table

Relevant External Links for POLR2J Gene

GeneLoc Exon Structure for
POLR2J
ECgene alternative splicing isoforms for
POLR2J

Expression for POLR2J Gene

mRNA expression in normal human tissues for POLR2J Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR2J Gene

This gene is overexpressed in Pancreas (38.8) and Lung (27.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POLR2J Gene



SOURCE GeneReport for Unigene cluster for POLR2J Gene Hs.654952

mRNA Expression by UniProt/SwissProt for POLR2J Gene

P52435-RPB11_HUMAN
Tissue specificity: Ubiquitously expressed. High expression was found in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with POLR2J: view

Protein tissue co-expression partners for POLR2J Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for POLR2J Gene

Orthologs for POLR2J Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2J Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POLR2J 35
  • 93.16 (n)
  • 100 (a)
POLR2J 36
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC100686835 35
  • 90.88 (n)
  • 100 (a)
-- 36
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Polr2j 35
  • 89.74 (n)
  • 100 (a)
Polr2j 16
Polr2j 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLR2J 35
  • 99.15 (n)
  • 100 (a)
POLR2J 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polr2j 35
  • 90.03 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 97 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 91 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2j 35
  • 78.92 (n)
  • 98.29 (a)
Str.10266 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5544 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17997 35
polr2j 35
  • 79.77 (n)
  • 95.73 (a)
polr2j 36
  • 96 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11022 35
fruit fly
(Drosophila melanogaster)
Insecta Rpb11 37
  • 78 (a)
Rpb11 35
  • 70.14 (n)
  • 78.26 (a)
Rpb11 36
  • 77 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta RPB11_ANOGA 35
  • 71.59 (n)
  • 74.78 (a)
worm
(Caenorhabditis elegans)
Secernentea W01G7.3 37
  • 70 (a)
rpb-11 35
  • 66.97 (n)
  • 70.64 (a)
rpb-11 36
  • 65 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB11 36
  • 46 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPB11 35
  • 55.96 (n)
  • 49.54 (a)
rice
(Oryza sativa)
Liliopsida Os07g0172500 35
  • 56.51 (n)
  • 53.33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12102 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6583 36
  • 81 (a)
OneToMany
Species with no ortholog for POLR2J:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR2J Gene

ENSEMBL:
Gene Tree for POLR2J (if available)
TreeFam:
Gene Tree for POLR2J (if available)

Paralogs for POLR2J Gene

Paralogs for POLR2J Gene

(4) SIMAP similar genes for POLR2J Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with POLR2J: view

Variants for POLR2J Gene

Sequence variations from dbSNP and Humsavar for POLR2J Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs11157 -- 102,474,372(+) TGGAG(A/C/G/T)AGCGC reference, stop-gained
rs1131325 -- 102,478,875(-) GACGC(A/G)ACGGC utr-variant-5-prime
rs2522915 -- 102,476,910(+) CACTG(A/C/G/T)AGCCT intron-variant
rs3873772 -- 102,474,765(-) AATCT(C/G)TTTCC intron-variant
rs4358740 -- 102,475,410(+) TTAGG(A/G)GCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR2J Gene

Variant ID Type Subtype PubMed ID
nsv428182 CNV Gain 18775914
nsv831083 CNV Loss 17160897
nsv464664 CNV Gain 19166990
nsv464665 CNV Loss 19166990
dgv7412n71 CNV Loss 21882294
nsv888832 CNV Loss 21882294
nsv5879 CNV Loss 18451855
nsv8192 CNV Gain 18304495
esv27624 CNV Gain+Loss 19812545
nsv471450 CNV Duplication 19718026
nsv482111 CNV Gain 20164927
nsv888836 CNV Loss 21882294
dgv7414n71 CNV Gain+Loss 21882294
dgv7415n71 CNV Gain+Loss 21882294
dgv7416n71 CNV Gain 21882294
dgv7417n71 CNV Gain 21882294
nsv888845 CNV Gain 21882294
dgv23n31 CNV Duplication 19718026

Variation tolerance for POLR2J Gene

Gene Damage Index Score: 0.14; 3.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR2J Gene

HapMap Linkage Disequilibrium report
POLR2J

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2J Gene

Disorders for POLR2J Gene

MalaCards: The human disease database

(1) MalaCards diseases for POLR2J Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POLR2J

Genetic Association Database (GAD)
POLR2J
Human Genome Epidemiology (HuGE) Navigator
POLR2J
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2J
genes like me logo Genes that share disorders with POLR2J: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR2J Gene

Publications for POLR2J Gene

  1. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PMID: 19237606) Michiels S. … Benhamou S. (Carcinogenesis 2009) 3 48 67
  2. [New genes on human chromosome 7: bioinformatic analysis of a gene cluster from the POLR2J family]. (PMID: 15586814) ShpakovskiA- D.G. … ShpakovskiA- G.V. (Bioorg. Khim. 2004) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Tip110 protein binds to unphosphorylated RNA polymerase II and promotes its phosphorylation and HIV-1 long terminal repeat transcription. (PMID: 24217245) Zhao W. … He J.J. (J. Biol. Chem. 2014) 3

Products for POLR2J Gene

Sources for POLR2J Gene

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