Aliases for POLR2J Gene
External Ids for POLR2J Gene
Previous GeneCards Identifiers for POLR2J Gene
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13. [provided by RefSeq, Jul 2008]
GeneCards Summary for POLR2J Gene
POLR2J (RNA Polymerase II Subunit J) is a Protein Coding gene. Diseases associated with POLR2J include Hiv-1. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and DNA damage_Role of Brca1 and Brca2 in DNA repair. GO annotations related to this gene include protein dimerization activity and RNA polymerase II activity. An important paralog of this gene is POLR2J3.
UniProtKB/Swiss-Prot for POLR2J Gene
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).