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Aliases for POLR2J Gene

Aliases for POLR2J Gene

  • Polymerase (RNA) II (DNA Directed) Polypeptide J, 13.3kDa 2 3
  • DNA-Directed RNA Polymerase II Subunit J-1 3 4
  • RNA Polymerase II 13.3 KDa Subunit 3 4
  • RNA Polymerase II Subunit B11-A 3 4
  • POLR2J1 3 4
  • RPB11A 3 4
  • Polymerase (RNA) II (DNA Directed) Polypeptide J (13.3kD) 2
  • DNA-Directed RNA Polymerase II Subunit RPB11-A 3
  • RPB11m 3
  • HRPB14 3
  • RPB11 3

External Ids for POLR2J Gene

Summaries for POLR2J Gene

Entrez Gene Summary for POLR2J Gene

  • This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2J Gene

POLR2J (Polymerase (RNA) II (DNA Directed) Polypeptide J, 13.3kDa) is a Protein Coding gene. Diseases associated with POLR2J include hiv-1. Among its related pathways are Disease and Epstein-Barr virus infection. GO annotations related to this gene include protein dimerization activity and RNA polymerase II activity. An important paralog of this gene is ENSG00000270249.

UniProtKB/Swiss-Prot for POLR2J Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).

Gene Wiki entry for POLR2J Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2J Gene

Genomics for POLR2J Gene

Genomic Location for POLR2J Gene

Start:
102,473,100 bp from pter
End:
102,478,999 bp from pter
Size:
5,900 bases
Orientation:
Minus strand

Genomic View for POLR2J Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POLR2J Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2J Gene

Regulatory Elements for POLR2J Gene

Proteins for POLR2J Gene

  • Protein details for POLR2J Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52435-RPB11_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB11-a
    Protein Accession:
    P52435
    Secondary Accessions:
    • A5D6V8
    • O43375

    Protein attributes for POLR2J Gene

    Size:
    117 amino acids
    Molecular mass:
    13293 Da
    Quaternary structure:
    • Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. Interacts with AATF.

neXtProt entry for POLR2J Gene

Proteomics data for POLR2J Gene at MOPED

Post-translational modifications for POLR2J Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys37, Lys47, Lys52, and Lys62

Other Protein References for POLR2J Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for POLR2J Gene

Domains for POLR2J Gene

Gene Families for POLR2J Gene

HGNC:
  • POLR :RNA polymerase subunits

Protein Domains for POLR2J Gene

UniProtKB/Swiss-Prot:

RPB11_HUMAN
Family:
  • Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.:
    • P52435
genes like me logo Genes that share domains with POLR2J: view

Function for POLR2J Gene

Molecular function for POLR2J Gene

UniProtKB/Swiss-Prot Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).

Gene Ontology (GO) - Molecular Function for POLR2J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001055 contributes_to RNA polymerase II activity IBA --
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed RNA polymerase activity TAS 8797801
GO:0005515 protein binding IPI 10783144
GO:0030275 LRR domain binding IPI 10783144
genes like me logo Genes that share ontologies with POLR2J: view

Phenotypes for POLR2J Gene

GenomeRNAi human phenotypes for POLR2J:
genes like me logo Genes that share phenotypes with POLR2J: view

miRNA for POLR2J Gene

miRTarBase miRNAs that target POLR2J

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for POLR2J Gene

Localization for POLR2J Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2J Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR2J Gene COMPARTMENTS Subcellular localization image for POLR2J gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for POLR2J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9852112
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex IDA 9852112
genes like me logo Genes that share ontologies with POLR2J: view

Pathways for POLR2J Gene

SuperPathways for POLR2J Gene

Superpath Contained pathways
1 Formation of RNA Pol II elongation complex
2 DNA Repair
3 mRNA Splicing - Major Pathway
4 HIV Life Cycle
5 Purine metabolism (KEGG)
genes like me logo Genes that share pathways with POLR2J: view

Pathways by source for POLR2J Gene

Gene Ontology (GO) - Biological Process for POLR2J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006289 nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated --
genes like me logo Genes that share ontologies with POLR2J: view

Transcripts for POLR2J Gene

mRNA/cDNA for POLR2J Gene

Unigene Clusters for POLR2J Gene

Polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2J Gene

No ASD Table

Relevant External Links for POLR2J Gene

GeneLoc Exon Structure for
POLR2J
ECgene alternative splicing isoforms for
POLR2J

Expression for POLR2J Gene

mRNA expression in normal human tissues for POLR2J Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for POLR2J Gene

SOURCE GeneReport for Unigene cluster for POLR2J Gene Hs.654952

mRNA Expression by UniProt/SwissProt for POLR2J Gene

P52435-RPB11_HUMAN
Tissue specificity: Ubiquitously expressed. High expression was found in heart and skeletal muscle.
genes like me logo Genes that share expressions with POLR2J: view

Orthologs for POLR2J Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2J Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR2J 36
  • 99.15 (n)
  • 100 (a)
POLR2J 37
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POLR2J 36
  • 93.16 (n)
  • 100 (a)
POLR2J 37
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 82 (a)
OneToMany
LOC100686835 36
  • 90.88 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Polr2j 36
  • 89.74 (n)
  • 100 (a)
Polr2j 16
Polr2j 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Polr2j 36
  • 90.03 (n)
  • 100 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 91 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.5544 36
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2j 36
  • 78.92 (n)
  • 98.29 (a)
Str.10266 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11022 36
zebrafish
(Danio rerio)
Actinopterygii Dr.17997 36
polr2j 36
  • 79.77 (n)
  • 95.73 (a)
polr2j 37
  • 96 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta RPB11_ANOGA 36
  • 71.59 (n)
  • 74.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rpb11 36
  • 70.14 (n)
  • 78.26 (a)
Rpb11 37
  • 77 (a)
OneToMany
Rpb11 38
  • 78 (a)
worm
(Caenorhabditis elegans)
Secernentea rpb-11 36
  • 66.97 (n)
  • 70.64 (a)
rpb-11 37
  • 65 (a)
OneToMany
W01G7.3 38
  • 70 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB11 37
  • 46 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPB11 36
  • 55.96 (n)
  • 49.54 (a)
rice
(Oryza sativa)
Liliopsida Os07g0172500 36
  • 56.51 (n)
  • 53.33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12102 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6583 37
  • 81 (a)
OneToMany
Species with no ortholog for POLR2J:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR2J Gene

ENSEMBL:
Gene Tree for POLR2J (if available)
TreeFam:
Gene Tree for POLR2J (if available)

Paralogs for POLR2J Gene

Paralogs for POLR2J Gene

Selected SIMAP similar genes for POLR2J Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with POLR2J: view

Variants for POLR2J Gene

Sequence variations from dbSNP and Humsavar for POLR2J Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs11157 -- 102,474,372(-) TGGAG(G/T)AGCGC reference, stop-gained
rs1131325 -- 102,478,875(-) GACGC(A/G)ACGGC utr-variant-5-prime
rs2522915 -- 102,476,910(+) CACTG(A/C/G/T)AGCCT intron-variant
rs4358740 -- 102,475,410(+) TTAGG(A/G)GCACT intron-variant
rs4556028 -- 102,474,008(+) CCACC(C/T)GGGGG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for POLR2J Gene

Variant ID Type Subtype PubMed ID
nsv428182 CNV Gain 18775914
nsv831083 CNV Loss 17160897
nsv464664 CNV Gain 19166990
nsv464665 CNV Loss 19166990
dgv7412n71 CNV Loss 21882294
nsv888832 CNV Loss 21882294
nsv5879 CNV Loss 18451855
nsv8192 CNV Gain 18304495
esv27624 CNV Gain+Loss 19812545
nsv471450 CNV Duplication 19718026
nsv482111 CNV Gain 20164927
nsv888836 CNV Loss 21882294
dgv7414n71 CNV Gain+Loss 21882294
dgv7415n71 CNV Gain+Loss 21882294
dgv7416n71 CNV Gain 21882294
dgv7417n71 CNV Gain 21882294
nsv888845 CNV Gain 21882294
dgv23n31 CNV Duplication 19718026

Relevant External Links for POLR2J Gene

HapMap Linkage Disequilibrium report
POLR2J

Disorders for POLR2J Gene

(1) MalaCards Diseases for POLR2J Gene

Search for POLR2J Gene in MalaCards »

Relevant External Links for POLR2J

Genetic Association Database (GAD)
POLR2J
Human Genome Epidemiology (HuGE) Navigator
POLR2J
genes like me logo Genes that share disorders with POLR2J: view

No data available for UniProtKB/Swiss-Prot for POLR2J Gene

Publications for POLR2J Gene

  1. A human RNA polymerase II subunit is encoded by a recently generated multigene family. (PMID: 11747469) Grandemange S. … Vigneron M. (BMC Mol. Biol. 2001) 4 23
  2. [New genes on human chromosome 7: bioinformatic analysis of a gene cluster from the POLR2J family]. (PMID: 15586814) ShpakovskiA- D.G. … ShpakovskiA- G.V. (Bioorg. Khim. 2004) 3 23
  3. Cloning of a novel human RNA polymerase II subunit downregulated by doxorubicin: new potential mechanisms of drug related toxicity. (PMID: 8797801) Fanciulli M. … Punturieri A. (FEBS Lett. 1996) 3 4
  4. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PMID: 9852112) Kershnar E. … Chiang C.-M. (J. Biol. Chem. 1998) 3 4
  5. Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb. (PMID: 10783144) Fanciulli M. … Passananti C. (FASEB J. 2000) 3 4

Products for POLR2J Gene

Sources for POLR2J Gene

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