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POLR2I Gene

protein-coding   GIFtS: 61
GCID: GC19M036604

Polymerase (RNA) II (DNA Directed) Polypeptide I, 14.5kDa

(Previous name: polymerase (RNA) II (DNA directed) polypeptide I (14.5kD))
  See POLR2I-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Polymerase (RNA) II (DNA Directed) Polypeptide I, 14.5kDa1 2     Polymerase (RNA) II (DNA Directed) Polypeptide I (14.5kD)1
RPB14.52 3     RPB92
DNA-Directed RNA Polymerase II Subunit I2 3     DNA-Directed RNA Polymerase II 14.5 KDa Polypeptide2
RNA Polymerase II 14.5 KDa Subunit2 3     DNA-Directed RNA Polymerase II Subunit RPB92
RNA Polymerase II Subunit B92 3     hRPB14.52

External Ids:    HGNC: 91961   Entrez Gene: 54382   Ensembl: ENSG000001052587   OMIM: 1806625   UniProtKB: P369543   
ORGUL members:         

Export aliases for POLR2I gene to outside databases

Previous GC identifers: GC19M037243 GC19M037053 GC19M041280 GC19M041296 GC19M033110


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POLR2I Gene:
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in
eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the
polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc
finger motifs with conserved cysteines and the subunit does possess zinc binding activity. (provided by RefSeq,
Jul 2008)

GeneCards Summary for POLR2I Gene:
POLR2I (polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa) is a protein-coding gene. Diseases associated with POLR2I include photosensitive trichothiodystrophy, and hiv-1. GO annotations related to this gene include DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot: RPB9_HUMAN, P36954
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional
non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is
composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the
central large cleft and thought to grab the incoming DNA template (By similarity)

Gene Wiki entry for POLR2I Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the POLR2I gene promoter:
         Pax-5   Tal-1   Pax-2   Pax-2a   LCR-F1   E47   GATA-1   PPAR-gamma1   HFH-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOLR2I promoter sequence
   Search Chromatin IP Primers for POLR2I

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POLR2I


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.12

POLR2I Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR2I gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M036604:  view genomic region     (about GC identifiers)

Start:
36,604,611 bp from pter      End:
36,606,248 bp from pter
Size:
1,638 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RPB9_HUMAN, P36954 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase II subunit RPB9  
Size: 125 amino acids; 14523 Da
Subunit: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits
Secondary accessions: B2R5J2 Q6NW05

Explore the universe of human proteins at neXtProt for POLR2I: NX_P36954

Explore proteomics data for POLR2I at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POLR2I Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006224.1  
    ENSEMBL proteins: 
     ENSP00000221859   ENSP00000465455   ENSP00000465755   ENSP00000467134  
    Reactome Protein details: P36954

    POLR2I Human Recombinant Protein Products:

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    antibodies-online proteins for POLR2I (10 products) 

     
    antibodies-online peptides for POLR2I

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POLR: RNA polymerase subunits

    4 InterPro protein domains:
     IPR001222 Znf_TFIIS
     IPR001529 DNA-dir_RNA_pol_M/15kDasu
     IPR012164 DNA-dir_RNApol_C11
     IPR019761 DNA-dir_RNA_pol-M_15_CS

    Graphical View of Domain Structure for InterPro Entry P36954

    ProtoNet protein and cluster: P36954

    1 Blocks protein domain: IPB001529 DNA-directed RNA polymerase

    UniProtKB/Swiss-Prot: RPB9_HUMAN, P36954
    Similarity: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family
    Similarity: Contains 1 TFIIS-type zinc finger


    Find genes that share domains with POLR2I           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPB9_HUMAN, P36954
    Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
    triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional
    non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is
    composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the
    central large cleft and thought to grab the incoming DNA template (By similarity)

         Genatlas biochemistry entry for POLR2I:
    polymerase II,RNA (DNA directed) small polypeptide I (14.5kDa)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003899contributes to DNA-directed RNA polymerase activity IBA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with POLR2I           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for POLR2I:
     Decreased viability  Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for POLR2I

    miRNA
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    miRTarBase miRNAs that target POLR2I:
    hsa-mir-1180-3p (MIRT035955), hsa-mir-1268a (MIRT035845), hsa-mir-328-3p (MIRT043800), hsa-mir-92a-3p (MIRT049323), hsa-mir-1 (MIRT023875)

    Block miRNA regulation of human, mouse, rat POLR2I using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate POLR2I:
    hsa-miR-556-3p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RPB9_HUMAN, P36954: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005665DNA-directed RNA polymerase II, core complex IDA9852112
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with POLR2I           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POLR2I About   (see all 16)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    mRNA Capping0.93
    Pausing and recovery of Tat-mediated HIV elongation0.72
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Tat-mediated HIV elongation arrest and recovery0.72
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Transcription of the HIV genome0.71
    Formation of the Early Elongation Complex0.77
    Abortive elongation of HIV-1 transcript in the absence of Tat0.70
    2Purine metabolism (KEGG)
    Purine metabolism0.38
    ATP ITP metabolism0.31
    Pyrimidine metabolism0.38
    3DNA Repair
    Transcription-coupled NER (TC-NER)0.90
    Formation of transcription-coupled NER (TC-NER) repair complex0.65
    Nucleotide Excision Repair0.90
    DNA Repair0.45
    Dual incision reaction in TC-NER0.65
    4mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA Splicing - Minor Pathway0.38
    5HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91


    Find genes that share SuperPaths with POLR2I           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for POLR2I
        Assembly of RNA Polymerase-II Initiation Complex
    Transcription of mRNA

    3 GeneGo (Thomson Reuters) Pathways for POLR2I
        DNA damage Role of Brca1 and Brca2 in DNA repair
    ATP/ITP metabolism
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for POLR2I
        Eukaryotic Transcription Initiation

    Selected Reactome Pathways for POLR2I (see all 31)
        Pausing and recovery of Tat-mediated HIV elongation
    Tat-mediated HIV elongation arrest and recovery
    Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript
    RNA Polymerase II Transcription Initiation And Promoter Clearance


    Selected Kegg Pathways  (Kegg details for POLR2I) (see all 6):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways
    RNA polymerase
    Huntington's disease

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POLR2I
    Interactions:

        Search GeneGlobe Interaction Network for POLR2I

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for POLR2I (P369543 ENSP000002218594) via UniProtKB, MINT, STRING, and/or I2D (see all 372)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    H3F3AP842433, ENSP000003557784I2D: score=4 STRING: ENSP00000355778
    H3F3BP842433, ENSP000002548104I2D: score=4 STRING: ENSP00000254810
    POLR2CP193873, ENSP000002192524I2D: score=6 STRING: ENSP00000219252
    POLR2GP624873, ENSP000003017884I2D: score=6 STRING: ENSP00000301788
    POLR2JP524353, ENSP000002926144I2D: score=4 STRING: ENSP00000292614
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0001193maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter IBA--
    GO:0006281DNA repair TAS--
    GO:0006283transcription-coupled nucleotide-excision repair TAS--
    GO:0006289nucleotide-excision repair TAS--

    Find genes that share ontologies with POLR2I           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POLR2I (RPB9)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for POLR2I gene: 
    NM_006233.4  

    Unigene Cluster for POLR2I:

    Polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
    Hs.47062  [show with all ESTs]
    Unigene Representative Sequence: BU598062
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589591 ENST00000221859(uc002ode.3 uc002odf.3) ENST00000585842
    ENST00000592962 ENST00000586789 ENST00000586439 ENST00000589069
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat POLR2I
      QuantiFast Probe-based Assays in human, mouse, rat POLR2I

    Additional mRNA sequence: 

    AK311176.1 AK312206.1 BC017112.1 BC017860.1 BC067794.1 

    9 DOTS entries:

    DT.448751  DT.454361  DT.100660282  DT.91890213  DT.91786015  DT.121454615  DT.95274340  DT.100660278 
    DT.121454637 

    Selected AceView cDNA sequences (see all 188):

    BI856416 BM129689 BQ013423 BQ679690 BC017112 BG829355 BQ682518 BE393135 
    BQ681080 F30947 AI476468 AI469435 H95458 F25479 AI016026 BF033890 
    BF968215 AI081841 BQ071460 BM852186 BM129169 AA861688 AI878818 NM_006233 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    POLR2I expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTGAAAAAA
    POLR2I Expression
    About this image


    POLR2I expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)
             Striatum
     
     Testis (Reproductive System)
    POLR2I Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POLR2I Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.47062
        Custom PCR Arrays for POLR2I
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2I

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for POLR2I gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Polr2i1 , 5 polymerase (RNA) II (DNA directed) polypeptide I1, 5 91.73(n)1
    100(a)1
      7 (17.34 cM)5
    699201  NM_027259.11  NP_081535.11 
     302319485 
    chicken
    (Gallus gallus)
    Aves POLR2I1 polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 85.33(n)
    94.4(a)
      426289  XM_423952.4  XP_423952.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.61932 Xenopus laevis transcribed sequence with strong similarity more 81.77(n)    48058597 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc56a082 Transcribed sequence with strong similarity to protein more 81.89(n)    BI868084.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpII151 , 3 transcription from Pol II promoter
    DNA-directed more3
    RNA polymerase II 15kD subunit1
    74(a)3
    77.78(n)1
    78.63(a)1
      88B33
    417411  NM_001260170.11  NP_001247099.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y97E10AR.53
    rpb-91
    rpb-91 62(a)3
    61.29(n)1
    62.1(a)1
      V(8013954-8014943)3
    1791781  NM_072661.41  NP_505062.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPB9(YGL070C)4
    RPB91
    RNA polymerase II subunit B12.6; contacts DNA; mutations more4
    RPB91
    46.6(n)1
    46.3(a)1
      7(374827-374459)4
    8528101, 4  NP_011445.11, 4 
    rice
    (Oryza sativa)
    Liliopsida Os12g05604001 Os12g0560400 64.1(n)
    59.62(a)
      4352511  NM_001073549.1  NP_001067017.1 


    ENSEMBL Gene Tree for POLR2I (if available)
    TreeFam Gene Tree for POLR2I (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for POLR2I:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833815CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POLR2I
    DNA2.0 Custom Variant and Variant Library Synthesis for POLR2I

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180662    OMIM disorders: --

    2 diseases for POLR2I:    
    About MalaCards
    photosensitive trichothiodystrophy    hiv-1

    2 diseases from the University of Copenhagen DISEASES database for POLR2I:
    Cockayne syndrome     Photosensitive trichothiodystrophy

    Find genes that share disorders with POLR2I           About GenesLikeMe


    Export disorders for POLR2I gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POLR2I gene, integrated from 10 sources (see all 104):
    (articles sorted by number of sources associating them with POLR2I)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PubMed id 9852112)1, 2 Kershnar E.... Chiang C.-M. (J. Biol. Chem. 1998)
    4. Chromosomal localization of human RNA polymerase II subunit genes. (PubMed id 8034326)1, 3 Acker J....Kedinger C. (Genomics 1994)
    5. Structure of the gene encoding the 14.5 kDa subunit of human RNA polymerase II. (PubMed id 8265347)1, 2 Acker J.... Kedinger C. (Nucleic Acids Res. 1993)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development. (PubMed id 22422068)1 Dahiya S....Wigdahl B. (J. Gen. Virol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5438 HGNC: 9196 AceView: POLR2I Ensembl:ENSG00000105258 euGenes: HUgn5438
    ECgene: POLR2I Kegg: 5438 H-InvDB: POLR2I

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for POLR2I Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for POLR2I gene:
    Search GeneIP for patents involving POLR2I

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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