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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POLR2I Gene

protein-coding   GIFtS: 60
GCID: GC19M036604

Polymerase (RNA) II (DNA Directed) Polypeptide I, 14.5kDa

(Previous name: polymerase (RNA) II (DNA directed) polypeptide I (14.5kD))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Polymerase (RNA) II (DNA Directed) Polypeptide I, 14.5kDa1 2     Polymerase (RNA) II (DNA Directed) Polypeptide I (14.5kD)1
RPB14.52 3     RPB92
DNA-Directed RNA Polymerase II Subunit I2 3     DNA-Directed RNA Polymerase II 14.5 KDa Polypeptide2
RNA Polymerase II 14.5 KDa Subunit2 3     DNA-Directed RNA Polymerase II Subunit RPB92
RNA Polymerase II Subunit B92 3     hRPB14.52

External Ids:    HGNC: 91961   Entrez Gene: 54382   Ensembl: ENSG000001052587   OMIM: 1806625   UniProtKB: P369543   

Export aliases for POLR2I gene to outside databases

Previous GC identifers: GC19M037243 GC19M037053 GC19M041280 GC19M041296 GC19M033110


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POLR2I Gene:
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in
eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the
polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc
finger motifs with conserved cysteines and the subunit does possess zinc binding activity. (provided by RefSeq,
Jul 2008)

GeneCards Summary for POLR2I Gene: 
POLR2I (polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa) is a protein-coding gene. Diseases associated with POLR2I include conjunctivitis, and huntington's disease, and among its related super-pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and Purine metabolism. GO annotations related to this gene include DNA-directed RNA polymerase activity and protein kinase activity.

UniProtKB/Swiss-Prot: RPB9_HUMAN, P36954
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional
non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is
composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the
central large cleft and thought to grab the incoming DNA template (By similarity)

Gene Wiki entry for POLR2I Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POLR2I gene promoter:
         Pax-5   Tal-1   Pax-2   Pax-2a   LCR-F1   E47   GATA-1   PPAR-gamma1   HFH-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOLR2I promoter sequence
   Search SABiosciences Chromatin IP Primers for POLR2I

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLR2I


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q12

POLR2I Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR2I gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M036604:  view genomic region     (about GC identifiers)

Start:
36,604,611 bp from pter      End:
36,606,248 bp from pter
Size:
1,638 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RPB9_HUMAN, P36954 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase II subunit RPB9  
Size: 125 amino acids; 14523 Da
Subunit: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits
Subcellular location: Nucleus
Secondary accessions: B2R5J2 Q6NW05

Explore the universe of human proteins at neXtProt for POLR2I: NX_P36954

Explore proteomics data for POLR2I at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P36954

  • POLR2I Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    POLR2I Protein Expression
    REFSEQ proteins: NP_006224.1  
    ENSEMBL proteins: 
     ENSP00000221859   ENSP00000465455   ENSP00000465755   ENSP00000467134  
    Reactome Protein details: P36954
    Human Recombinant Protein Products for POLR2I: 
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for POLR2I
    Cloud-Clone Corp. Proteins for POLR2I 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9852112
    GO:0005654nucleoplasm TAS--
    GO:0005665DNA-directed RNA polymerase II, core complex IDA9852112

    POLR2I for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    POLR: RNA polymerase subunits

    4 InterPro protein domains:
     IPR001222 Znf_TFIIS
     IPR001529 DNA-dir_RNA_pol_M/15kDasu
     IPR012164 DNA-dir_RNApol_C11
     IPR019761 DNA-dir_RNA_pol-M_15_CS

    Graphical View of Domain Structure for InterPro Entry P36954

    ProtoNet protein and cluster: P36954

    1 Blocks protein domain: IPB001529 DNA-directed RNA polymerase

    UniProtKB/Swiss-Prot: RPB9_HUMAN, P36954
    Similarity: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family
    Similarity: Contains 1 TFIIS-type zinc finger


    POLR2I for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPB9_HUMAN, P36954
    Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
    triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional
    non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is
    composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the
    central large cleft and thought to grab the incoming DNA template (By similarity)

         Genatlas biochemistry entry for POLR2I:
    polymerase II,RNA (DNA directed) small polypeptide I (14.5kDa)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003899DNA-directed RNA polymerase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    POLR2I for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for POLR2I:
     Decreased viability  Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for POLR2I 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for POLR2I About   (see all 16)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Pausing and recovery of Tat-mediated HIV elongation0.73
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Tat-mediated HIV elongation arrest and recovery0.73
    mRNA Capping0.93
    RNA Polymerase II Pre-transcription Events0.72
    HIV Transcription Elongation0.78
    Abortive elongation of HIV-1 transcript in the absence of Tat0.72
    2Purine metabolism
    Purine metabolism0.38
    ATP/ITP metabolism0.31
    Pyrimidine metabolism0.38
    3mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA Splicing0.82
    mRNA Processing0.85
    mRNA Splicing - Minor Pathway0.40
    mRNA Splicing - Major Pathway0.82
    4HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    5Nucleotide Excision Repair
    Nucleotide Excision Repair0.90
    DNA Repair0.46
    Transcription-coupled NER (TC-NER)0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for POLR2I
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    DNA damage Role of Brca1 and Brca2 in DNA repair
    ATP/ITP metabolism

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POLR2I
        Assembly of RNA Polymerase-II Initiation Complex
    Transcription of mRNA

    3 GeneGo (Thomson Reuters) Pathways for POLR2I
        DNA damage Role of Brca1 and Brca2 in DNA repair
    ATP/ITP metabolism
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for POLR2I
        Eukaryotic Transcription Initiation

    5/44        Reactome Pathways for POLR2I (see all 44)
        Tat-mediated HIV elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    mRNA Splicing
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    Regulatory RNA pathways


    5/6         Kegg Pathways  (Kegg details for POLR2I) (see all 6):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways
    RNA polymerase
    Huntington's disease


    POLR2I for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POLR2I

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/263 Interacting proteins for POLR2I (P369543 ENSP000002218594) via UniProtKB, MINT, STRING, and/or I2D (see all 263)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR2CP193873, ENSP000002192524I2D: score=6 STRING: ENSP00000219252
    POLR2EP193883, ENSP000002155874I2D: score=6 STRING: ENSP00000215587
    POLR2GP624873, ENSP000003017884I2D: score=6 STRING: ENSP00000301788
    H3F3AP842433I2D: score=4 
    H3F3BP842433I2D: score=4 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006281DNA repair TAS--
    GO:0006283transcription-coupled nucleotide-excision repair TAS--
    GO:0006289nucleotide-excision repair TAS--
    GO:0006351transcription, DNA-dependent ----

    POLR2I for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for POLR2I:
    Small Molecule - inhibitor
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    Browse Tocris compounds for POLR2I (RPB9)

    Search CenterWatch for drugs/clinical trials and news about POLR2I / RPB9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POLR2I gene: 
    NM_006233.4  

    Unigene Cluster for POLR2I:

    Polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
    Hs.47062  [show with all ESTs]
    Unigene Representative Sequence: BU598062
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589591 ENST00000221859(uc002ode.3 uc002odf.3) ENST00000585842
    ENST00000592962 ENST00000586789 ENST00000586439 ENST00000589069
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AK311176.1 AK312206.1 BC017112.1 BC017860.1 BC067794.1 

    9 DOTS entries:

    DT.448751  DT.454361  DT.100660282  DT.91890213  DT.91786015  DT.121454615  DT.95274340  DT.100660278 
    DT.121454637 

    24/188 AceView cDNA sequences (see all 188):

    BM129169 AA861688 AI431455 AI081841 NM_006233 BM852186 AI476468 BQ681080 
    BQ679690 BQ013423 F30947 AI469435 BG829355 BF968215 BE393135 BC017112 
    BQ682518 H95458 BI856416 AI878818 BM129689 AI016026 BF033890 F25479 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POLR2I expression in normal human tissues (normalized intensities)      POLR2I embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTGAAAAAA
    POLR2I Expression
    About this image


    POLR2I expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Striatum
             brain/midbrain   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   
     
     Bone (Gastrulation Derivatives)
             skeleton/cranium   
     
     Cartilage (Muscoskeletal System)
             skeleton/cranium   

    See POLR2I Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POLR2I

    SOURCE GeneReport for Unigene cluster: Hs.47062
        SABiosciences Custom PCR Arrays for POLR2I
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2I

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for POLR2I gene from 9/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Polr2i1 , 5 polymerase (RNA) II (DNA directed) polypeptide I1, 5 91.73(n)1
    100(a)1
      7 (17.34 cM)5
    699201  NM_027259.11  NP_081535.11 
     302319485 
    chicken
    (Gallus gallus)
    Aves POLR2I1 polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 85.33(n)
    94.4(a)
      426289  XM_423952.3  XP_423952.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.61932 Xenopus laevis transcribed sequence with strong similarity more 81.77(n)    48058597 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc56a082 Transcribed sequence with strong similarity to protein more 81.89(n)    BI868084.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpII151 , 3 transcription from Pol II promoter
    DNA-directed more3
    RNA polymerase II 15kD subunit1
    74(a)3
    77.5(n)1
    77.5(a)1
      88B33
    417411  NM_169575.21  NP_731898.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y97E10AR.53
    rpb-91
    Protein RPB-91 62(a)3
    61.29(n)1
    62.1(a)1
      V(8013954-8014943)3
    1791781  NM_072661.31  NP_505062.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPB9(YGL070C)4
    RPB91
    RNA polymerase II subunit B12.6; contacts DNA; mutations more4
    Rpb9p1
    46.42(n)1
    46.73(a)1
      7(374827-374459)4
    8528101, 4  NP_011445.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NRPB9A1 DNA-directed RNA polymerase II subunit I 62.16(n)
    63.96(a)
      820954  NM_112574.2  NP_188323.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g01022001 hypothetical protein 64.56(n)
    53.15(a)
      4331295  NM_001055195.1  NP_001048660.1 


    ENSEMBL Gene Tree for POLR2I (if available)
    TreeFam Gene Tree for POLR2I (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for POLR2I:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833815CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing POLR2I
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 180662    OMIM disorders: --

    2 diseases for POLR2I:    About MalaCards
    conjunctivitis    huntington's disease

    2 diseases from the University of Copenhagen DISEASES database for POLR2I:
    Cockayne syndrome     Photosensitive trichothiodystrophy

    POLR2I for disorders           About GeneDecksing


    Export disorders for POLR2I gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POLR2I gene, integrated from 9 sources (see all 101):
    (articles sorted by number of sources associating them with POLR2I)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PubMed id 9852112)1, 2 Kershnar E.... Chiang C.-M. (1998)
    4. Chromosomal localization of human RNA polymerase II subunit genes. (PubMed id 8034326)1, 3 Acker J....Kedinger C. (1994)
    5. Structure of the gene encoding the 14.5 kDa subunit of human RNA polymerase II. (PubMed id 8265347)1, 2 Acker J.... Kedinger C. (1993)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development. (PubMed id 22422068)1 Dahiya S....Wigdahl B. (2012)
    9. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5438 HGNC: 9196 AceView: POLR2I Ensembl:ENSG00000105258 euGenes: HUgn5438
    ECgene: POLR2I Kegg: 5438 H-InvDB: POLR2I

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POLR2I Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for POLR2I gene:
    Search GeneIP for patents involving POLR2I

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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