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Aliases for POLR2I Gene

Aliases for POLR2I Gene

  • RNA Polymerase II Subunit I 2 3 5
  • DNA-Directed RNA Polymerase II Subunit I 3 4
  • RNA Polymerase II 14.5 KDa Subunit 3 4
  • RNA Polymerase II Subunit B9 3 4
  • RPB14.5 3 4
  • Polymerase (RNA) II (DNA Directed) Polypeptide I (14.5kD) 2
  • Polymerase (RNA) II (DNA Directed) Polypeptide I, 14.5kDa 3
  • DNA-Directed RNA Polymerase II 14.5 KDa Polypeptide 3
  • DNA-Directed RNA Polymerase II Subunit RPB9 3
  • Polymerase (RNA) II Subunit I 3
  • HRPB14.5 3
  • RPB9 3

External Ids for POLR2I Gene

Previous GeneCards Identifiers for POLR2I Gene

  • GC19M037243
  • GC19M037053
  • GC19M041280
  • GC19M041296
  • GC19M036604
  • GC19M033110

Summaries for POLR2I Gene

Entrez Gene Summary for POLR2I Gene

  • This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2I Gene

POLR2I (RNA Polymerase II Subunit I) is a Protein Coding gene. Diseases associated with POLR2I include Hiv-1. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and DNA damage_Role of Brca1 and Brca2 in DNA repair. GO annotations related to this gene include nucleic acid binding and DNA-directed 5-3 RNA polymerase activity.

UniProtKB/Swiss-Prot for POLR2I Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).

Gene Wiki entry for POLR2I Gene

Additional gene information for POLR2I Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2I Gene

Genomics for POLR2I Gene

Regulatory Elements for POLR2I Gene

Enhancers for POLR2I Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H035701 2 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +412.7 412746 1.6 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 ZNF416 ZNF143 ZNF548 FOS ZNF567 PROSER3 TMEM147-AS1 ZNF599 HAUS5 U2AF1L4 KMT2B ENSG00000267049 ZNF792 ZNF146
GH19H035461 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +652.4 652395 1.9 HDGF PKNOX1 ZNF493 ZFP64 ZNF121 ATF7 KLF7 RUNX3 ZNF202 SP3 TMEM147-AS1 HAUS5 ZNF599 PROSER3 KMT2B RBM42 ZNF146 SDHAF1 ZNF792 ZFP82
GH19H035710 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +400.2 400154 10 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF529 ZFP82 U2AF1L4 ZNF567 TMEM147-AS1 RBM42 LINC00665 ZNF461 PROSER3 ZNF529-AS1
GH19H035641 1.7 FANTOM5 ENCODE dbSUPER 10.6 +471.8 471816 4.6 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 KMT2B RBM42 TMEM147-AS1 PROSER3 ZNF792 HAUS5 ZNF529 ZNF566 ZNF181 ENSG00000267049
GH19H035946 1.6 FANTOM5 Ensembl ENCODE 10.7 +168.0 167954 0.8 HDGF ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF302 ZNF416 ZNF143 ZNF548 ZNF567 ZNF345 ZNF850 TMEM147-AS1 PROSER3 HAUS5 ZNF790 ZNF529 KMT2B ZNF790-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLR2I on UCSC Golden Path with GeneCards custom track

Promoters for POLR2I Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109113 246 2201 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Locations for POLR2I Gene

Genomic Locations for POLR2I Gene
chr19:36,113,709-36,115,346
(GRCh38/hg38)
Size:
1,638 bases
Orientation:
Minus strand
chr19:36,604,611-36,606,248
(GRCh37/hg19)

Genomic View for POLR2I Gene

Genes around POLR2I on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2I Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2I Gene

Proteins for POLR2I Gene

  • Protein details for POLR2I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36954-RPB9_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB9
    Protein Accession:
    P36954
    Secondary Accessions:
    • B2R5J2
    • Q6NW05

    Protein attributes for POLR2I Gene

    Size:
    125 amino acids
    Molecular mass:
    14523 Da
    Quaternary structure:
    • Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.

    Three dimensional structures from OCA and Proteopedia for POLR2I Gene

neXtProt entry for POLR2I Gene

Post-translational modifications for POLR2I Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POLR2I Gene

No data available for DME Specific Peptides for POLR2I Gene

Domains & Families for POLR2I Gene

Gene Families for POLR2I Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for POLR2I Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P36954

UniProtKB/Swiss-Prot:

RPB9_HUMAN :
  • Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
Family:
  • Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
genes like me logo Genes that share domains with POLR2I: view

Function for POLR2I Gene

Molecular function for POLR2I Gene

GENATLAS Biochemistry:
polymerase II,RNA (DNA directed) small polypeptide I (14.5kDa)
UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).

Gene Ontology (GO) - Molecular Function for POLR2I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003899 contributes_to DNA-directed 5-3 RNA polymerase activity IBA --
GO:0008270 zinc ion binding TAS,IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with POLR2I: view
genes like me logo Genes that share phenotypes with POLR2I: view

Animal Model Products

CRISPR Products

miRNA for POLR2I Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2I Gene

Localization for POLR2I Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2I Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR2I gene
Compartment Confidence
nucleus 5
extracellular 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for POLR2I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 9852112
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex IDA 9852112
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with POLR2I: view

Pathways & Interactions for POLR2I Gene

SuperPathways for POLR2I Gene

SuperPathway Contained pathways
1 Formation of HIV elongation complex in the absence of HIV Tat
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 mRNA Capping
4 HIV Life Cycle
.45
5 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
genes like me logo Genes that share pathways with POLR2I: view

Gene Ontology (GO) - Biological Process for POLR2I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter IBA --
GO:0006283 transcription-coupled nucleotide-excision repair IBA,TAS --
GO:0006351 transcription, DNA-templated TAS,IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with POLR2I: view

No data available for SIGNOR curated interactions for POLR2I Gene

Drugs & Compounds for POLR2I Gene

(4) Drugs for POLR2I Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for POLR2I Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with POLR2I: view

Transcripts for POLR2I Gene

Unigene Clusters for POLR2I Gene

Polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2I Gene

No ASD Table

Relevant External Links for POLR2I Gene

GeneLoc Exon Structure for
POLR2I
ECgene alternative splicing isoforms for
POLR2I

Expression for POLR2I Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR2I Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR2I Gene

This gene is overexpressed in Peripheral blood mononuclear cells (43.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POLR2I Gene



Protein tissue co-expression partners for POLR2I Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLR2I Gene:

POLR2I

SOURCE GeneReport for Unigene cluster for POLR2I Gene:

Hs.47062

Evidence on tissue expression from TISSUES for POLR2I Gene

  • Nervous system(4.5)
  • Muscle(2.9)
genes like me logo Genes that share expression patterns with POLR2I: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR2I Gene

Orthologs for POLR2I Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2I Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia POLR2I 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLR2I 33 34
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia POLR2I 33 34
  • 94.13 (n)
cow
(Bos Taurus)
Mammalia POLR2I 33 34
  • 93.33 (n)
mouse
(Mus musculus)
Mammalia Polr2i 33 16 34
  • 91.73 (n)
chicken
(Gallus gallus)
Aves POLR2I 33 34
  • 85.33 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2i 33
  • 77.07 (n)
Str.10772 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6193 33
zebrafish
(Danio rerio)
Actinopterygii polr2i 33 34
  • 80.44 (n)
wufc56a08 33
fruit fly
(Drosophila melanogaster)
Insecta RpII15 35 33 34
  • 77.78 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008393 33
  • 75.5 (n)
worm
(Caenorhabditis elegans)
Secernentea Y97E10AR.5 35
  • 62 (a)
rpb-9 33 34
  • 61.29 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL088W 33
  • 53.4 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03234g 33
  • 48.46 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB9 33 34 36
  • 46.6 (n)
rice
(Oryza sativa)
Liliopsida Os12g0560400 33
  • 64.1 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.5887 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1691 34
  • 75 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb9 33
  • 50.3 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7809 33
Species where no ortholog for POLR2I was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR2I Gene

ENSEMBL:
Gene Tree for POLR2I (if available)
TreeFam:
Gene Tree for POLR2I (if available)

Paralogs for POLR2I Gene

No data available for Paralogs for POLR2I Gene

Variants for POLR2I Gene

Sequence variations from dbSNP and Humsavar for POLR2I Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000451021 -- 36,115,441(+) GCGGA(G/T)TGGTC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000549581 -- 36,116,748(+) CCCAG(A/C)CTCCC intron-variant, upstream-variant-2KB
rs1001152552 -- 36,115,513(+) AGCGG(A/G)TGTGA nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001171651 -- 36,114,324(+) GCTCA(A/G)GGCCC intron-variant, upstream-variant-2KB
rs1001269753 -- 36,115,324(+) CGTGA(A/T)CTATG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for POLR2I Gene

Variant ID Type Subtype PubMed ID
nsv833815 CNV loss 17160897

Variation tolerance for POLR2I Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR2I Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR2I

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2I Gene

Disorders for POLR2I Gene

MalaCards: The human disease database

(1) MalaCards diseases for POLR2I Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POLR2I

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2I
genes like me logo Genes that share disorders with POLR2I: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR2I Gene

Publications for POLR2I Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PMID: 9852112) Kershnar E … Chiang CM (The Journal of biological chemistry 1998) 3 4 60
  4. Chromosomal localization of human RNA polymerase II subunit genes. (PMID: 8034326) Acker J … Kedinger C (Genomics 1994) 2 3 60
  5. Structure of the gene encoding the 14.5 kDa subunit of human RNA polymerase II. (PMID: 8265347) Acker J … Kedinger C (Nucleic acids research 1993) 3 4 60

Products for POLR2I Gene

Sources for POLR2I Gene

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