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Aliases for POLR2I Gene

Aliases for POLR2I Gene

  • Polymerase (RNA) II Subunit I 2 3
  • Polymerase (RNA) II (DNA Directed) Polypeptide I, 14.5kDa 3 5
  • DNA-Directed RNA Polymerase II Subunit I 3 4
  • RNA Polymerase II 14.5 KDa Subunit 3 4
  • RNA Polymerase II Subunit B9 3 4
  • RPB14.5 3 4
  • Polymerase (RNA) II (DNA Directed) Polypeptide I (14.5kD) 2
  • DNA-Directed RNA Polymerase II 14.5 KDa Polypeptide 3
  • HRPB14.5 3
  • RPB9 3

External Ids for POLR2I Gene

Previous GeneCards Identifiers for POLR2I Gene

  • GC19M037243
  • GC19M037053
  • GC19M041280
  • GC19M041296
  • GC19M036604
  • GC19M033110

Summaries for POLR2I Gene

Entrez Gene Summary for POLR2I Gene

  • This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2I Gene

POLR2I (Polymerase (RNA) II Subunit I) is a Protein Coding gene. Diseases associated with POLR2I include hiv-1. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include nucleic acid binding and DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot for POLR2I Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).

Gene Wiki entry for POLR2I Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2I Gene

Genomics for POLR2I Gene

Regulatory Elements for POLR2I Gene

Promoters for POLR2I Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POLR2I on UCSC Golden Path with GeneCards custom track

Genomic Location for POLR2I Gene

Chromosome:
19
Start:
36,113,709 bp from pter
End:
36,115,346 bp from pter
Size:
1,638 bases
Orientation:
Minus strand

Genomic View for POLR2I Gene

Genes around POLR2I on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2I Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2I Gene

Proteins for POLR2I Gene

  • Protein details for POLR2I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36954-RPB9_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB9
    Protein Accession:
    P36954
    Secondary Accessions:
    • B2R5J2
    • Q6NW05

    Protein attributes for POLR2I Gene

    Size:
    125 amino acids
    Molecular mass:
    14523 Da
    Quaternary structure:
    • Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.

neXtProt entry for POLR2I Gene

Proteomics data for POLR2I Gene at MOPED

Post-translational modifications for POLR2I Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POLR2I Gene

Antibody Products

No data available for DME Specific Peptides for POLR2I Gene

Domains & Families for POLR2I Gene

Gene Families for POLR2I Gene

Suggested Antigen Peptide Sequences for POLR2I Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P36954

UniProtKB/Swiss-Prot:

RPB9_HUMAN :
  • Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
  • Contains 1 TFIIS-type zinc finger.
Family:
  • Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
Similarity:
  • Contains 1 TFIIS-type zinc finger.
genes like me logo Genes that share domains with POLR2I: view

Function for POLR2I Gene

Molecular function for POLR2I Gene

GENATLAS Biochemistry:
polymerase II,RNA (DNA directed) small polypeptide I (14.5kDa)
UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).

Gene Ontology (GO) - Molecular Function for POLR2I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003899 DNA-directed RNA polymerase activity IEA --
genes like me logo Genes that share ontologies with POLR2I: view
genes like me logo Genes that share phenotypes with POLR2I: view

Animal Model Products

miRNA for POLR2I Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2I Gene

Localization for POLR2I Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2I Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR2I Gene COMPARTMENTS Subcellular localization image for POLR2I gene
Compartment Confidence
nucleus 5
extracellular 3

No data available for Gene Ontology (GO) - Cellular Components for POLR2I Gene

Pathways & Interactions for POLR2I Gene

SuperPathways for POLR2I Gene

Superpath Contained pathways
1 Formation of the HIV-1 Early Elongation Complex
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
4 mRNA Splicing - Major Pathway
5 Signaling by FGFR2 in disease
genes like me logo Genes that share pathways with POLR2I: view

Gene Ontology (GO) - Biological Process for POLR2I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter IBA --
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with POLR2I: view

No data available for SIGNOR curated interactions for POLR2I Gene

Drugs & Compounds for POLR2I Gene

(5) Drugs for POLR2I Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with POLR2I: view

Transcripts for POLR2I Gene

Unigene Clusters for POLR2I Gene

Polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2I Gene

No ASD Table

Relevant External Links for POLR2I Gene

GeneLoc Exon Structure for
POLR2I
ECgene alternative splicing isoforms for
POLR2I

Expression for POLR2I Gene

mRNA expression in normal human tissues for POLR2I Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR2I Gene

This gene is overexpressed in Peripheral blood mononuclear cells (43.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLR2I Gene



SOURCE GeneReport for Unigene cluster for POLR2I Gene Hs.47062

genes like me logo Genes that share expression patterns with POLR2I: view

Protein tissue co-expression partners for POLR2I Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLR2I Gene

Orthologs for POLR2I Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2I Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POLR2I 35
  • 93.33 (n)
  • 99.2 (a)
POLR2I 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR2I 35
  • 94.13 (n)
  • 100 (a)
POLR2I 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr2i 35
  • 91.73 (n)
  • 100 (a)
Polr2i 16
Polr2i 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLR2I 35
  • 99.47 (n)
  • 100 (a)
POLR2I 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLR2I 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves POLR2I 35
  • 85.33 (n)
  • 94.4 (a)
POLR2I 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2i 35
  • 77.07 (n)
  • 96 (a)
Str.10772 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6193 35
zebrafish
(Danio rerio)
Actinopterygii polr2i 35
  • 80.44 (n)
  • 95.87 (a)
wufc56a08 35
polr2i 36
  • 93 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RpII15 37
  • 74 (a)
RpII15 35
  • 77.78 (n)
  • 78.63 (a)
RpII15 36
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008393 35
  • 75.5 (n)
  • 77.78 (a)
worm
(Caenorhabditis elegans)
Secernentea Y97E10AR.5 37
  • 62 (a)
rpb-9 35
  • 61.29 (n)
  • 62.1 (a)
rpb-9 36
  • 46 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL088W 35
  • 53.4 (n)
  • 43.52 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03234g 35
  • 48.46 (n)
  • 47.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB9 35
  • 46.6 (n)
  • 46.3 (a)
RPB9 36
  • 41 (a)
OneToOne
RPB9 38
barley
(Hordeum vulgare)
Liliopsida Hv.5887 35
rice
(Oryza sativa)
Liliopsida Os12g0560400 35
  • 64.1 (n)
  • 59.62 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7809 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb9 35
  • 50.3 (n)
  • 49.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1691 36
  • 75 (a)
OneToOne
Species with no ortholog for POLR2I:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR2I Gene

ENSEMBL:
Gene Tree for POLR2I (if available)
TreeFam:
Gene Tree for POLR2I (if available)

Paralogs for POLR2I Gene

No data available for Paralogs for POLR2I Gene

Variants for POLR2I Gene

Structural Variations from Database of Genomic Variants (DGV) for POLR2I Gene

Variant ID Type Subtype PubMed ID
nsv833815 CNV Loss 17160897

Variation tolerance for POLR2I Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR2I Gene

HapMap Linkage Disequilibrium report
POLR2I

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for POLR2I Gene

Disorders for POLR2I Gene

MalaCards: The human disease database

(1) MalaCards diseases for POLR2I Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POLR2I

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2I
genes like me logo Genes that share disorders with POLR2I: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR2I Gene

Publications for POLR2I Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 67
  2. Chromosomal localization of human RNA polymerase II subunit genes. (PMID: 8034326) Acker J. … Kedinger C. (Genomics 1994) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Tip110 protein binds to unphosphorylated RNA polymerase II and promotes its phosphorylation and HIV-1 long terminal repeat transcription. (PMID: 24217245) Zhao W. … He J.J. (J. Biol. Chem. 2014) 3

Products for POLR2I Gene

Sources for POLR2I Gene

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