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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POLR2I Gene

protein-coding   GIFtS: 59
GCID: GC19M036604

polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa

(Previous name: polymerase (RNA) II (DNA directed) polypeptide I (14.5kD)...)
 Explore 7 diseases affiliated with
POLR2I via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for POLR2I    

Aliases
for POLR2I gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Polymerase (RNA) II (DNA Directed) Polypeptide I, 14.5kDa1 2     RNA Polymerase II 14.5 KDa Subunit2 3
RPB91 2     RNA Polymerase II Subunit B92 3
HRPB14.51     Polymerase (RNA) II (DNA Directed) Polypeptide I (14.5kD)1
RPB14.52 3     DNA-Directed RNA Polymerase II 14.5 KDa Polypeptide2
DNA-Directed RNA Polymerase II Subunit I2 3     DNA-Directed RNA Polymerase II Subunit RPB92

External Ids:    HGNC: 91961   Entrez Gene: 54382   Ensembl: ENSG000001052587   OMIM: 1806625   UniProtKB: P369543   

Export aliases for POLR2I gene to outside databases

Previous GC identifers: GC19M037243 GC19M037053 GC19M041280 GC19M041296 GC19M033110


Summaries
for POLR2I gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for POLR2I:
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in
eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the
polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger
motifs with conserved cysteines and the subunit does possess zinc binding activity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RPB9_HUMAN, P36954
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional
non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is
composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central
large cleft and thought to grab the incoming DNA template (By similarity)

Gene Wiki entry for POLR2I


Genomic Views
for POLR2I gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POLR2I gene promoter:
         Pax-5   Tal-1   Pax-2   Pax-2a   LCR-F1   E47   GATA-1   PPAR-gamma1   HFH-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: POLR2I promoter sequence
   Search SABiosciences Chromatin IP Primers for POLR2I

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLR2I


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q12

POLR2I Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR2I gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M036604:  view genomic region     (about GC identifiers)

Start:
 36,604,611 bp from pter      End:
 36,606,248 bp from pter
Size:
 1,638 bases      Orientation:
 minus strand

Proteins
for POLR2I gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RPB9_HUMAN, P36954 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase II subunit RPB9  
Size: 125 amino acids; 14523 Da
Subunit: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits
Subcellular location: Nucleus
Secondary accessions: B2R5J2 Q6NW05

Explore the universe of human proteins at neXtProt for POLR2I: NX_P36954

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P36954

    • POLR2I Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006224.1  
    ENSEMBL proteins: 
     ENSP00000221859   ENSP00000465455   ENSP00000465755   ENSP00000467134  
    Reactome Protein details: P36954
    Human Recombinant Protein Products: 
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    Novus Biologicals POLR2I Proteins
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for POLR2I

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9852112
    GO:0005654nucleoplasm TAS--
    GO:0005665DNA-directed RNA polymerase II, core complex IDA9852112


    POLR2I for ontologies           About GeneDecksing



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    Uscn Antibodies for POLR2I
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    Uscn ELISAs and CLIAs for POLR2I

    Protein Domains /
    Families
    for POLR2I gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    POLR2I for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001222 Znf_TFIIS
     IPR001529 DNA-dir_RNA_pol_M/15kDasu
     IPR012164 DNA-dir_RNApol_C11
     IPR019761 DNA-dir_RNA_pol-M_15_CS

    Graphical View of Domain Structure for InterPro Entry P36954

    ProtoNet protein and cluster: P36954

    1 Blocks protein family: IPB001529 DNA-directed RNA polymerase

    UniProtKB/Swiss-Prot: RPB9_HUMAN, P36954
    Similarity: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family
    Similarity: Contains 1 TFIIS-type zinc finger


    Function
    for POLR2I gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RPB9_HUMAN, P36954
    Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
    triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional
    non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is
    composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central
    large cleft and thought to grab the incoming DNA template (By similarity)

         Genatlas biochemistry entry for POLR2I:
    polymerase II,RNA (DNA directed) small polypeptide I (14.5kDa)

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate POLR2I:
    hsa-miR-556-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLR2I (see all 7)
    OriGene shRNA RFP: POLR2I
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for POLR2I

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR2I 

    Cell Line
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    Search LifeMap BioReagents cell lines for POLR2I

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2I

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003899DNA-directed RNA polymerase activity IEA--
    GO:0004672contributes to protein kinase activity IDA9852112
    GO:0008270zinc ion binding IEA--


    POLR2I for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for POLR2I:
     Decreased viability  Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 


    Pathways & Interactions
    for POLR2I gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Formation of RNA Pol II elongation complex
    8/35 pathways (see all 35)
    		RNA Polymerase II Transcription Elongation1.00
    		RNA Pol II CTD phosphorylation and interaction with CE0.55
    		Formation of HIV-1 elongation complex in the absence of HIV-1 Tat1.00
    		Dual incision reaction in TC-NER0.46
    		Formation of RNA Pol II elongation complex 1.00
    		Formation of transcription-coupled NER (TC-NER) repair complex0.46
    		Formation of HIV-1 elongation complex containing HIV-1 Tat0.98
    		Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition0.40
    2mRNA Splicing - Major Pathway
    		mRNA Splicing1.00
    		mRNA Processing0.82
    		mRNA Splicing - Major Pathway1.00
    		mRNA Splicing - Minor Pathway0.40
    		Processing of Capped Intron-Containing Pre-mRNA0.96
    3HIV Infection
    		HIV Infection1.00
    		Transcription Ligand-Dependent Transcription of Retinoid-Target genes0.28
    		Transcription_Ligand-Dependent Transcription of Retinoid-Target genes0.28
    4Nucleotide Excision Repair
    		Nucleotide Excision Repair1.00
    		DNA Repair0.46
    		Transcription-coupled NER (TC-NER)0.90
    5Late Phase of HIV Life Cycle
    		Late Phase of HIV Life Cycle1.00
    		HIV Life Cycle0.90

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for POLR2I
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    DNA damage Role of Brca1 and Brca2 in DNA repair
    ATP/ITP metabolism

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POLR2I
        Assembly of RNA Polymerase-II Initiation Complex
    Transcription of mRNA

    3 GeneGo (Thomson Reuters) Pathways for POLR2I
        DNA damage Role of Brca1 and Brca2 in DNA repair
    ATP/ITP metabolism
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for POLR2I 
        Eukaryotic Transcription Initiation

    5/49        Reactome Pathways for POLR2I (see all 49)
        Tat-mediated HIV-1 elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    mRNA Splicing
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    Addition of the fourth nucleotide on the Nascent Transcript: Second Transition


    5         Kegg Pathways  (Kegg details for POLR2I):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways
    RNA polymerase
    Huntington's disease


    POLR2I for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POLR2I

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/263 Interacting proteins for POLR2I (P369543 ENSP000002218594) via UniProtKB, MINT, STRING, and/or I2D (see all 263)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR2CP193873, ENSP000002192524I2D: score=6 STRING: ENSP00000219252
    POLR2EP193883, ENSP000002155874I2D: score=6 STRING: ENSP00000215587
    POLR2GP624873, ENSP000003017884I2D: score=6 STRING: ENSP00000301788
    H3F3AP842433I2D: score=4 
    H3F3BP842433I2D: score=4 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006281DNA repair TAS--
    GO:0006283transcription-coupled nucleotide-excision repair TAS--
    GO:0006289nucleotide-excision repair TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--


    POLR2I for ontologies           About GeneDecksing



    Drugs & Compounds
    for POLR2I gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for POLR2I:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POLR2I
    Search CenterWatch for drugs/clinical trials and news about POLR2I / RPB9 

    Transcripts
    for POLR2I gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for POLR2I gene: 
    NM_006233.4  

    Unigene Cluster for POLR2I:

    Polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
    Hs.47062  [show with all ESTs]
    Unigene Representative Sequence: BU598062
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589591 ENST00000221859(uc002ode.3 uc002odf.3) ENST00000585842
    ENST00000592962 ENST00000586789 ENST00000586439 ENST00000589069

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate POLR2I:
    hsa-miR-556-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLR2I (see all 7)
    OriGene shRNA RFP: POLR2I
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR2I
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR2I

    Additional cDNA sequence: 

    AK311176.1 AK312206.1 BC017112.1 BC017860.1 BC067794.1 

    9 DOTS entries:

    DT.448751  DT.454361  DT.100660282  DT.91890213  DT.91786015  DT.121454615  DT.95274340  DT.100660278 
    DT.121454637 

    24/188 AceView cDNA sequences (see all 188):

    BQ681080 BE393135 AI469435 BQ679690 AI081841 F04880 AA861688 BM852186 
    BQ071460 AI476468 BF033890 AI431455 F25479 BM129169 H95458 BQ682518 
    BF968215 NM_006233 BM129689 AI878818 BI856416 BC017112 AI016026 BQ013423 

    GeneLoc Exon Structure


    Expression
    for POLR2I gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POLR2I expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGTGAAAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    POLR2I expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeVentral Foregut EndodermGut Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See POLR2I Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POLR2I

    SOURCE GeneReport for Unigene cluster: Hs.47062
        SABiosciences Custom PCR Arrays for POLR2I
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2I

    Orthologs
    for POLR2I gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for POLR2I gene from 9/33 species (see all 33)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Polr2i1 , 5 polymerase (RNA) II (DNA directed) polypeptide I1, 5 91.73(n)1
    100(a)1    		   7 (17.34 cM)5
    699201  NM_027259.11  NP_081535.11 
     302319485 
    chicken
    (Gallus gallus)    		 Aves POLR2I1 polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 85.33(n)
    94.4(a)    		   426289  XM_423952.3  XP_423952.2 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.61932 Xenopus laevis transcribed sequence with strong similarity more 81.77(n)    48058597 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc56a082 Transcribed sequence with strong similarity to protein more 81.89(n)    BI868084.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta RpII151 , 3 transcription from Pol II promoter
    DNA-directed more3
    RNA polymerase II 15kD subunit1    		 74(a)3
    77.5(n)1
    77.5(a)1    		   88B33
    417411  NM_169575.21  NP_731898.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y97E10AR.53
    rpb-91    		 Protein RPB-91 62(a)3
    61.29(n)1
    62.1(a)1    		   V(8013954-8014943)3
    1791781  NM_072661.31  NP_505062.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RPB9(YGL070C)4
    RPB91    		 RNA polymerase II subunit B12.6; contacts DNA; mutations more4
    Rpb9p1    		 46.42(n)1
    46.73(a)1    		   7(374827-374459)4
    8528101, 4  NP_011445.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons NRPB9A1 DNA-directed RNA polymerase II subunit I 62.16(n)
    63.96(a)    		   820954  NM_112574.2  NP_188323.1 
    rice
    (Oryza sativa)    		 Liliopsida Os03g01022001 hypothetical protein 64.56(n)
    53.15(a)    		   4331295  NM_001055195.1  NP_001048660.1 


    ENSEMBL Gene Tree for POLR2I (if available)
    TreeFam Gene Tree for POLR2I (if available) 

    Paralogs
    for POLR2I gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for POLR2I gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for POLR2I
         1 CNV: 5098
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POLR2I
    DNA2.0 Custom Variant and Variant Library Synthesis for POLR2I

    Disorders / Diseases
    for POLR2I gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    POLR2I for disorders           About GeneDecksing

    OMIM gene information: 180662    OMIM disorders: --

    7 diseases for POLR2I:    About MalaCards
    photosensitive trichthiodystrophy    cockayne syndrome    huntington's disease    conjunctivitis
    pneumonia    immunodeficiency    malaria

    2 diseases from the University of Copenhagen DISEASES database for POLR2I:
    Cockayne syndrome     Photosensitive trichothiodystrophy

    Export disorders for POLR2I gene to outside databases

    Publications
    for POLR2I gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POLR2I gene, integrated from 9 sources (see all 98):
    (articles sorted by number of sources associating them with POLR2I)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PubMed id 9852112)1, 2 Kershnar E.... Chiang C.-M. (1998)
    4. Chromosomal localization of human RNA polymerase II subunit genes. (PubMed id 8034326)1, 3 Acker J....Kedinger C. (1994)
    5. Structure of the gene encoding the 14.5 kDa subunit of human RNA polymerase II. (PubMed id 8265347)1, 2 Acker J.... Kedinger C. (1993)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development. (PubMed id 22422068)1 Dahiya S....Wigdahl B. (2012)
    9. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for POLR2I gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing POLR2I gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5438 HGNC: 9196 AceView: POLR2I Ensembl:ENSG00000105258 euGenes: HUgn5438
    ECgene: POLR2I Kegg: 5438 H-InvDB: POLR2I

    Other Databases showing POLR2I gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing POLR2I gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POLR2I Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for POLR2I gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for POLR2I gene:
    Search GeneIP for patents involving POLR2I

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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