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Aliases for POLR2H Gene

Aliases for POLR2H Gene

  • Polymerase (RNA) II (DNA Directed) Polypeptide H 2 3
  • DNA-Directed RNA Polymerases I, II, And III 17.1 KDa Polypeptide 3 4
  • DNA-Directed RNA Polymerase II Subunit H 3 4
  • RPB8 Homolog 3 4
  • RPB17 3 4
  • RPB8 3 6
  • DNA-Directed RNA Polymerases I, II, And III Subunit RPABC3 3
  • RNA Polymerases I, II, And III Subunit ABC3 4
  • RPABC3 3
  • HRPB8 4

External Ids for POLR2H Gene

Previous GeneCards Identifiers for POLR2H Gene

  • GC03M180516
  • GC03P185074
  • GC03P185481
  • GC03P185402
  • GC03P185563
  • GC03P184079
  • GC03P181487

Summaries for POLR2H Gene

Entrez Gene Summary for POLR2H Gene

  • The three eukaryotic RNA polymerases are complex multisubunit enzymes that play a central role in the transcription of nuclear genes. This gene encodes an essential and highly conserved subunit of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for POLR2H Gene

POLR2H (Polymerase (RNA) II (DNA Directed) Polypeptide H) is a Protein Coding gene. Diseases associated with POLR2H include hiv-1. Among its related pathways are Disease and Epstein-Barr virus infection. GO annotations related to this gene include DNA-directed RNA polymerase activity and RNA polymerase II activity.

UniProtKB/Swiss-Prot for POLR2H Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

Gene Wiki entry for POLR2H Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2H Gene

Genomics for POLR2H Gene

Regulatory Elements for POLR2H Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for POLR2H Gene

Start:
184,361,714 bp from pter
End:
184,368,596 bp from pter
Size:
6,883 bases
Orientation:
Plus strand

Genomic View for POLR2H Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POLR2H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2H Gene

Proteins for POLR2H Gene

  • Protein details for POLR2H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52434-RPAB3_HUMAN
    Recommended name:
    DNA-directed RNA polymerases I, II, and III subunit RPABC3
    Protein Accession:
    P52434
    Secondary Accessions:
    • C9J413
    • C9JBJ6
    • C9JCU7
    • C9JUA8
    • P53802
    • Q969R0

    Protein attributes for POLR2H Gene

    Size:
    150 amino acids
    Molecular mass:
    17143 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively. Directly interacts with POLR2A.

    Three dimensional structures from OCA and Proteopedia for POLR2H Gene

    Alternative splice isoforms for POLR2H Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLR2H Gene

Proteomics data for POLR2H Gene at MOPED

Post-translational modifications for POLR2H Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for POLR2H Gene

Domains for POLR2H Gene

Gene Families for POLR2H Gene

HGNC:
  • POLR :RNA polymerase subunits

Protein Domains for POLR2H Gene

Suggested Antigen Peptide Sequences for POLR2H Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52434

UniProtKB/Swiss-Prot:

RPAB3_HUMAN :
  • P52434
Family:
  • Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2H: view

Function for POLR2H Gene

Molecular function for POLR2H Gene

UniProtKB/Swiss-Prot Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

Gene Ontology (GO) - Molecular Function for POLR2H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001054 contributes_to RNA polymerase I activity IBA --
GO:0001055 contributes_to RNA polymerase II activity IBA --
GO:0001056 contributes_to RNA polymerase III activity IBA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with POLR2H: view
genes like me logo Genes that share phenotypes with POLR2H: view

miRNA for POLR2H Gene

miRTarBase miRNAs that target POLR2H

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POLR2H

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for POLR2H Gene

Localization for POLR2H Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2H Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR2H Gene COMPARTMENTS Subcellular localization image for POLR2H gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3

Gene Ontology (GO) - Cellular Components for POLR2H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex IDA 9852112
GO:0005666 DNA-directed RNA polymerase III complex IBA --
GO:0005736 DNA-directed RNA polymerase I complex IBA --
genes like me logo Genes that share ontologies with POLR2H: view

Pathways for POLR2H Gene

SuperPathways for POLR2H Gene

Superpath Contained pathways
1 Formation of RNA Pol II elongation complex
2 RNA Polymerase III Transcription Initiation
3 DNA Repair
4 mRNA Splicing - Major Pathway
5 RNA Polymerase I Promoter Opening
genes like me logo Genes that share pathways with POLR2H: view

Interacting Proteins for POLR2H Gene

Gene Ontology (GO) - Biological Process for POLR2H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006289 nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated --
genes like me logo Genes that share ontologies with POLR2H: view

Transcripts for POLR2H Gene

Unigene Clusters for POLR2H Gene

Polymerase (RNA) II (DNA directed) polypeptide H:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POLR2H

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2H Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - -
SP9:
SP10: -

Relevant External Links for POLR2H Gene

GeneLoc Exon Structure for
POLR2H
ECgene alternative splicing isoforms for
POLR2H

Expression for POLR2H Gene

mRNA expression in normal human tissues for POLR2H Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for POLR2H Gene

SOURCE GeneReport for Unigene cluster for POLR2H Gene Hs.432574

genes like me logo Genes that share expressions with POLR2H: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLR2H Gene

Orthologs for POLR2H Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR2H 35
  • 99.73 (n)
  • 99.18 (a)
cow
(Bos Taurus)
Mammalia POLR2H 35
  • 93.56 (n)
  • 100 (a)
POLR2H 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR2H 35
  • 92.89 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Polr2h 35
  • 92 (n)
  • 100 (a)
Polr2h 16
Polr2h 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLR2H 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLR2H 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polr2h 35
  • 90.44 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves POLR2H 35
  • 82.22 (n)
  • 100 (a)
POLR2H 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLR2H 36
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25337 35
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2h 35
  • 77.78 (n)
  • 98 (a)
Str.7362 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3078 35
zebrafish
(Danio rerio)
Actinopterygii polr2h 35
  • 79.56 (n)
  • 97.33 (a)
polr2h 36
  • 97 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012397 35
  • 65.56 (n)
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rpb8 35
  • 68.68 (n)
  • 78.52 (a)
Rpb8 36
  • 79 (a)
OneToOne
Rpb8 37
  • 78 (a)
worm
(Caenorhabditis elegans)
Secernentea rpb-8 35
  • 63.29 (n)
  • 64.19 (a)
rpb-8 36
  • 64 (a)
OneToOne
F26F4.11 37
  • 63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB8 36
  • 35 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPB8A 35
  • 56.26 (n)
  • 49.65 (a)
rice
(Oryza sativa)
Liliopsida Os03g0845700 35
  • 57.82 (n)
  • 47.62 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5023 36
  • 74 (a)
OneToOne
Species with no ortholog for POLR2H:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR2H Gene

ENSEMBL:
Gene Tree for POLR2H (if available)
TreeFam:
Gene Tree for POLR2H (if available)

Paralogs for POLR2H Gene

No data available for Paralogs for POLR2H Gene

Variants for POLR2H Gene

Sequence variations from dbSNP and Humsavar for POLR2H Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1802869 -- 184,368,506(+) ATGTA(A/T)ATGAT utr-variant-3-prime
rs4912484 -- 184,367,171(+) TGTGT(G/T)GCTAC intron-variant
rs4912485 -- 184,367,270(+) GTAAG(C/T)AATTT intron-variant
rs7615189 -- 184,364,131(+) GCTTC(A/C)CAGCG intron-variant
rs7652854 -- 184,365,715(+) acgcc(A/T)gtaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR2H Gene

Variant ID Type Subtype PubMed ID
nsv878057 CNV Loss 21882294
nsv878060 CNV Loss 21882294
nsv829813 CNV Loss 17160897
esv2422400 CNV Duplication 17116639
nsv822363 CNV Gain 20364138
esv2225212 CNV Deletion 18987734
esv2726298 CNV Deletion 23290073
esv2675995 CNV Deletion 23128226

Relevant External Links for POLR2H Gene

HapMap Linkage Disequilibrium report
POLR2H

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2H Gene

Disorders for POLR2H Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for POLR2H Gene including...

Search for POLR2H Gene in MalaCards »

Relevant External Links for POLR2H

Genetic Association Database (GAD)
POLR2H
Human Genome Epidemiology (HuGE) Navigator
POLR2H
genes like me logo Genes that share disorders with POLR2H: view

No data available for UniProtKB/Swiss-Prot for POLR2H Gene

Publications for POLR2H Gene

  1. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PMID: 9852112) Kershnar E. … Chiang C.-M. (J. Biol. Chem. 1998) 3 4
  2. Six human RNA polymerase subunits functionally substitute for their yeast counterparts. (PMID: 8524256) McKune K. … Woychik N.A. (Mol. Cell. Biol. 1995) 3 4
  3. Structural, biochemical, and dynamic characterizations of the hRPB8 subunit of human RNA polymerases. (PMID: 16632472) Kang X. … Jin C. (J. Biol. Chem. 2006) 3 4
  4. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PMID: 19237606) Michiels S. … Benhamou S. (Carcinogenesis 2009) 3 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for POLR2H Gene

Sources for POLR2H Gene

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