Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POLR2G Gene

protein-coding   GIFtS: 62
GCID: GC11P062529

Polymerase (RNA) II (DNA Directed) Polypeptide G

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Polymerase (RNA) II (DNA Directed) Polypeptide G1 2     DNA Directed RNA Polymerase II 19 Kda Polypeptide2
RPB192 3     DNA-Directed RNA Polymerase II 19 KDa Polypeptide2
RPB72 3     DNA-Directed RNA Polymerase II Subunit RPB72
DNA-Directed RNA Polymerase II Subunit G2 3     hRPB192
RNA Polymerase II 19 KDa Subunit2 3     hsRPB72
RNA Polymerase II Subunit B72 3     RNA Polymerase II Seventh Subunit2

External Ids:    HGNC: 91941   Entrez Gene: 54362   Ensembl: ENSG000001680027   OMIM: 6020135   UniProtKB: P624873   
ORGUL members:         
NONCODE14:n341043      

Export aliases for POLR2G gene to outside databases

Previous GC identifers: GC11P065041 GC11P064104 GC11P062779 GC11P062304 GC11P062285 GC11P058857


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POLR2G Gene:
This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing
messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help
stabilize transcribing polyermase molecules during elongation. (provided by RefSeq, Jan 2009)

GeneCards Summary for POLR2G Gene: 
POLR2G (polymerase (RNA) II (DNA directed) polypeptide G) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with POLR2G include adenocarcinoma in situ, and ovarian endometriosis, and among its related super-pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and Purine metabolism. GO annotations related to this gene include DNA-directed RNA polymerase activity and RNA binding.

UniProtKB/Swiss-Prot: RPB7_HUMAN, P62487
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional
non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is
composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds
to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to
lock the clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site
cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA

Gene Wiki entry for POLR2G Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POLR2G gene promoter:
         ER-alpha   p53   MyoD   FOXD1   E2F-2   XBP-1   E2F-1   E2F   ZIC2/Zic2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOLR2G promoter sequence
   Search SABiosciences Chromatin IP Primers for POLR2G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLR2G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q13.1

POLR2G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR2G gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P062529:  view genomic region     (about GC identifiers)

Start:
62,529,011 bp from pter      End:
62,534,187 bp from pter
Size:
5,177 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RPB7_HUMAN, P62487 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase II subunit RPB7  
Size: 172 amino acids; 19294 Da
Subunit: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a
subcomplex that protrudes from the 10-subunit Pol II core complex
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for POLR2G:
2C35 (3D)    
Secondary accessions: B2R5C0 P52433 Q2M1Z4

Explore the universe of human proteins at neXtProt for POLR2G: NX_P62487

Explore proteomics data for POLR2G at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62487

  • POLR2G Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    POLR2G Protein Expression
    REFSEQ proteins: NP_002687.1  
    ENSEMBL proteins: 
     ENSP00000301788   ENSP00000432198   ENSP00000433529   ENSP00000431624   ENSP00000433877  
     ENSP00000435669  
    Reactome Protein details: P62487
    Human Recombinant Protein Products for POLR2G: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for POLR2G
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for POLR2G
    GenScript Custom Purified and Recombinant Proteins Services for POLR2G
    Novus Biologicals POLR2G Proteins
    Novus Biologicals POLR2G Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for POLR2G 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9852112
    GO:0005654nucleoplasm TAS--
    GO:0005665DNA-directed RNA polymerase II, core complex IDA9852112

    POLR2G for ontologies           About GeneDecksing



    POLR2G Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for POLR2G
    OriGene Custom Antibody Services for POLR2G
    GenScript Custom Superior Antibodies Services for POLR2G
    Novus Biologicals POLR2G Antibodies
    Abcam antibodies for POLR2G
    Cloud-Clone Corp. Antibodies for POLR2G 
    ThermoFisher Antibodies for POLR2G
    LSBio Antibodies in human, mouse, rat for POLR2G 

    Assay Products for POLR2G: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for POLR2G
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for POLR2G
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for POLR2G 
    Cloud-Clone Corp. CLIAs for POLR2G


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    POLR: RNA polymerase subunits

    4 InterPro protein domains:
     IPR003029 Rbsml_prot_S1_RNA-bd_dom
     IPR005576 RNA_pol_Rpb7_N
     IPR012340 NA-bd_OB-fold
     IPR022967 RNA-binding_domain_S1

    Graphical View of Domain Structure for InterPro Entry P62487

    ProtoNet protein and cluster: P62487

    UniProtKB/Swiss-Prot: RPB7_HUMAN, P62487
    Similarity: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family


    POLR2G for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPB7_HUMAN, P62487
    Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
    triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional
    non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is
    composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds
    to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to
    lock the clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site
    cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA

         Genatlas biochemistry entry for POLR2G:
    polymerase II,RNA (DNA dependent,polypeptide G,expressed in retina,brain,kidney,closely linked to D11S1765)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0003899DNA-directed RNA polymerase activity IEA--
         
    POLR2G for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for POLR2G:
     Elongated cells  Upregulation of Wnt/beta-caten  Wnt reporter downregulated 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for POLR2G 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POLR2G

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POLR2G 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POLR2G 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLR2G
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate POLR2G
    SwitchGear 3'UTR luciferase reporter plasmidPOLR2G 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for POLR2G
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLR2G

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for POLR2G
    Sirion Biotech Customized adenovirus for overexpression of POLR2G

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for POLR2G (see all 7)
    OriGene ORF clones in mouse, rat for POLR2G
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POLR2G (NM_002696)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLR2G
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR2G
    Sirion Biotech Customized lentivirus for stable overexpression of POLR2G 
                         Customized lentivirus expression plasmids for stable overexpression of POLR2G 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for POLR2G
    Search LifeMap BioReagents cell lines for POLR2G
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2G


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for POLR2G About   (see all 16)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Pausing and recovery of Tat-mediated HIV elongation0.73
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Tat-mediated HIV elongation arrest and recovery0.73
    mRNA Capping0.93
    RNA Polymerase II Pre-transcription Events0.72
    HIV Transcription Elongation0.78
    Abortive elongation of HIV-1 transcript in the absence of Tat0.72
    2Purine metabolism
    Purine metabolism0.38
    ATP/ITP metabolism0.31
    Pyrimidine metabolism0.38
    3mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA Splicing0.82
    mRNA Processing0.85
    mRNA Splicing - Minor Pathway0.40
    mRNA Splicing - Major Pathway0.82
    4HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    5Nucleotide Excision Repair
    Nucleotide Excision Repair0.90
    DNA Repair0.46
    Transcription-coupled NER (TC-NER)0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for POLR2G
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    DNA damage Role of Brca1 and Brca2 in DNA repair
    ATP/ITP metabolism

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POLR2G
        Assembly of RNA Polymerase-II Initiation Complex
    Transcription of mRNA

    3 GeneGo (Thomson Reuters) Pathways for POLR2G
        DNA damage Role of Brca1 and Brca2 in DNA repair
    ATP/ITP metabolism
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for POLR2G
        Eukaryotic Transcription Initiation

    5/44        Reactome Pathways for POLR2G (see all 44)
        Tat-mediated HIV elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    mRNA Splicing
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    Regulatory RNA pathways


    5/6         Kegg Pathways  (Kegg details for POLR2G) (see all 6):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways
    RNA polymerase
    Huntington's disease


    POLR2G for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POLR2G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/274 Interacting proteins for POLR2G (P624872, 3 ENSP000003017884) via UniProtKB, MINT, STRING, and/or I2D (see all 274)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206342P498422, 3, ENSP000003728174MINT-62582 MINT-62756 MINT-62680 I2D: score=5 STRING: ENSP00000372817
    ENSG00000236250P498422, 3, ENSP000003917984MINT-62582 MINT-62756 MINT-62680 I2D: score=5 STRING: ENSP00000391798
    STK19P498422, 3, ENSP000003644824MINT-62582 MINT-62756 MINT-62680 I2D: score=5 STRING: ENSP00000364482
    ENSG00000226033P498422, 3MINT-62582 MINT-62756 MINT-62680 I2D: score=5 
    ENSG00000226257P498422, 3MINT-62582 MINT-62756 MINT-62680 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006281DNA repair TAS--
    GO:0006283transcription-coupled nucleotide-excision repair TAS--
    GO:0006289nucleotide-excision repair TAS--
    GO:0006351transcription, DNA-dependent ----

    POLR2G for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for POLR2G:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POLR2G (RPB7)

    Search CenterWatch for drugs/clinical trials and news about POLR2G / RPB7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POLR2G gene: 
    NM_002696.2  

    Unigene Cluster for POLR2G:

    Polymerase (RNA) II (DNA directed) polypeptide G
    Hs.14839  [show with all ESTs]
    Unigene Representative Sequence: BM919120
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301788(uc001nva.3) ENST00000533442 ENST00000525455 ENST00000524819
    ENST00000531944 ENST00000527435 ENST00000531996 ENST00000526368
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLR2G
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate POLR2G
    SwitchGear 3'UTR luciferase reporter plasmidPOLR2G 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for POLR2G
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLR2G
    Clone
    Products:
         
    OriGene clones in human, mouse for POLR2G (see all 7)
    OriGene ORF clones in mouse, rat for POLR2G
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POLR2G (NM_002696)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLR2G
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR2G
    Sirion Biotech Customized lentivirus for stable overexpression of POLR2G 
                         Customized lentivirus expression plasmids for stable overexpression of POLR2G 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for POLR2G
    OriGene qSTAR qPCR primer pairs in human, mouse for POLR2G
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POLR2G
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR2G
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR2G

    Additional mRNA sequence: 

    AK312131.1 BC112162.1 BC112164.1 U20659.1 

    14 DOTS entries:

    DT.117130  DT.95324417  DT.95324419  DT.100662199  DT.95324422  DT.100740706  DT.120747586  DT.95324423 
    DT.100662198  DT.92365871  DT.95324420  DT.120747584  DT.120747651  DT.100662200 

    24/280 AceView cDNA sequences (see all 280):

    BM794053 BM718909 BE865484 AI419458 BU688192 AI609711 BQ437558 BQ050722 
    BE796653 AW328729 BM680767 BQ676946 AI302361 AW612634 BM970236 CD366379 
    CR596896 BQ674622 CR607005 BQ573965 BM702127 BM467741 BE741057 CA309812 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for POLR2G (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                          -                 -     -     -     -                                 
    SP2:                          -                       -     -     -                                 
    SP3:                          -                 -     -                 -                           
    SP4:                          -                 -     -     -     -     -                           
    SP5:                                            -     -     -     -                                 


    ECgene alternative splicing isoforms for POLR2G

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POLR2G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACAAGACA
    POLR2G Expression
    About this image


    See POLR2G Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POLR2G

    SOURCE GeneReport for Unigene cluster: Hs.14839
        SABiosciences Custom PCR Arrays for POLR2G
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for POLR2G
    OriGene qSTAR qPCR primer pairs in human, mouse for POLR2G
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POLR2G
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR2G
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR2G
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for POLR2G gene from 9/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Polr2g1 , 5 polymerase (RNA) II (DNA directed) polypeptide G1, 5 90.31(n)1
    100(a)1
      19 (5.62 cM)5
    677101  NM_026329.21  NP_080605.11 
     87931295 
    lizard
    (Anolis carolinensis)
    Reptilia POLR2G6
    Uncharacterized protein
    96(a)
    1 ↔ 1
    GL343928.1(105389-113090)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW639912.12   -- 80.65(n)    AW639912.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc18d052 wufc18d05 81.14(n)   324088  BC045299.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rpb71 CG31155-PA 70.74(n)
    81.4(a)
      261631  NM_169622.2  NP_731983.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y54E10BR.63
    rpb-71
    Protein RPB-71 77(a)3
    70(n)1
    77.65(a)1
      I(3031339-3032939)3
    1718771  NM_058692.41  NP_491093.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPB7(YDR404C)4
    RPB71
    RNA polymerase II subunit B16; forms two subunit dissociable more4
    Rpb7p1
    49.11(n)1
    43.79(a)1
      4(1277169-1276654)4
    8520131, 4  NP_010692.31  NP_010692.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NRPB71 DNA-directed RNA polymerase II subunit RPB7 58.67(n)
    53.8(a)
      836036  NM_125308.3  NP_200726.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g04007001 hypothetical protein 61.01(n)
    53.22(a)
      4338726  NM_001062018.1  NP_001055483.1 


    ENSEMBL Gene Tree for POLR2G (if available)
    TreeFam Gene Tree for POLR2G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/208 SNPs in POLR2G are shown (see all 208)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1134077751,2
    C--58857299(+) TATCAATCT/-  
            
    ATCTA
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs2021326621,2
    --62527064(+) TCCAA-/TTTTTT 1 -- us2k10--------
    rs112312061,2
    C--62527157(+) TCAAGA/GCATTC 1 -- us2k10--------
    rs25105371,2
    --62527179(+) cctctG/Ttagta 1 -- us2k10--------
    rs25105381,2
    --62527180(+) ctcttG/Tagtag 1 -- us2k10--------
    rs1497825441,2
    --62527250(+) GGGTTA/TTCACT 1 -- us2k10--------
    rs1457068901,2
    C--62527417(+) GATCAC/TCTGAG 1 -- us2k10--------
    rs612970471,2
    C,F--62527563(+) CTTCCC/TGGGTT 1 -- us2k11Minor allele frequency- T:0.06EA 120
    rs1174266331,2
    F--62527599(+) CCCAGT/CAGCCG 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs357308431,2
    C,F,H--62527634(+) CCACCA/CGTGCC 1 -- us2k119Minor allele frequency- C:0.19NS EA NA WA CSA 2219

    HapMap Linkage Disequilibrium report for POLR2G (62529011 - 62534187 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for POLR2G:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv483055CNV Loss15286789
    nsv897623CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing POLR2G
    DNA2.0 Custom Variant and Variant Library Synthesis for POLR2G

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602013    OMIM disorders: --

    6 diseases for POLR2G:    About MalaCards
    adenocarcinoma in situ    ovarian endometriosis    endometriosis    conjunctivitis
    huntington's disease    adenocarcinoma


    POLR2G for disorders           About GeneDecksing


    Export disorders for POLR2G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POLR2G gene, integrated from 9 sources (see all 119):
    (articles sorted by number of sources associating them with POLR2G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology. (PubMed id 7579693)1, 2, 3, 9 Khazak V.... Golemis E.A. (1995)
    2. Human gene for the RNA polymerase II seventh subunit (hsRPB7): structure, expression and chromosomal localization. (PubMed id 9256063)1, 2, 3 Schoen T.J.... Rodriguez I.R. (1997)
    3. Crystal structure and RNA binding of the Rpb4/Rpb7 subunits of human RNA polymerase II. (PubMed id 16282592)1, 2 Meka H.... Brick P. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PubMed id 9852112)1, 2 Kershnar E.... Chiang C.-M. (1998)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    9. The RNA Pol II sub-complex hsRpb4/7 is required for vi ability of multiple human cell lines. (PubMed id 23073835)1 Zhao Y....Lee K.A. (2012)
    10. Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development. (PubMed id 22422068)1 Dahiya S....Wigdahl B. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5436 HGNC: 9194 AceView: POLR2G Ensembl:ENSG00000168002 euGenes: HUgn5436
    ECgene: POLR2G Kegg: 5436 H-InvDB: POLR2G

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POLR2G Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for POLR2G Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for POLR2G gene:
    Search GeneIP for patents involving POLR2G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore small molecules (inhibitor) for POLR2G
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for POLR2G   OriGene RNAi products in human, mouse, rat for POLR2G  
     OriGene qPCR primer pairs and template standards for POLR2G   OriGene Protein Over-expression Lysate for POLR2G  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for POLR2G  
     OriGene qSTAR qPCR primer pairs in human, mouse for POLR2G   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for POLR2G   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for POLR2G   OriGene Custom Protein Services for POLR2G  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POLR2G
     QIAGEN SeqTarget long-range PCR primers for resequencing POLR2G
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLR2G
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLR2G
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR2G
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR2G
     GenScript Custom Purified and Recombinant Proteins Services for POLR2G GenScript cDNA clones with any tag delivered in your preferred vector for POLR2G
     GenScript Custom Assay Services for POLR2G GenScript Custom Superior Antibodies Services for POLR2G
     GenScript Custom overexpressing Cell Line Services for POLR2G CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in POLR2G promoter
     Search Chromatin IP Primers for POLR2G
     RT2 qPCR Primer Assay in human, mouse, rat POLR2G
     GNC Network for POLR2G
     SABiosciences PCR Arrays including human, mouse, rat POLR2G
     Search Tocris compounds for POLR2G (RPB7)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     POLR2G antibodies
     POLR2G proteins
     POLR2G lysates
     Antibodies for POLR2G
     See all of Abcam's Antibodies, Kits and Proteins for POLR2G
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for POLR2G
     Antibodies for POLR2G
     ELISAs for POLR2G
     CLIAs for POLR2G
     Search LifeMap BioReagents cell lines for POLR2G
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2G
     SwitchGear 3'UTR luciferase reporter plasmids for POLR2G
     SwitchGear Promoter luciferase reporter plasmids for POLR2G
     ThermoFisher Antibodies for POLR2G
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR2G
     inGenious Targeting Laboratory - Custom generated mouse model solutions for POLR2G
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POLR2G
    Customized:
     lentivirus for stable overexpression of POLR2G
     lentivirus expression plasmids for stable overexpression of POLR2G
     adenovirus for overexpression of POLR2G
     LSBio Antibodies in human, mouse, rat for POLR2G
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      POLR2G gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4