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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POLR2G Gene

protein-coding   GIFtS: 62
GCID: GC11P062529

polymerase (RNA) II (DNA directed) polypeptide G

 Explore 8 diseases affiliated with
POLR2G via our new
 Human Malady Compendium 
Biological research products
for POLR2G
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Polymerase (RNA) II (DNA Directed) Polypeptide G1 2     RNA Polymerase II 19 KDa Subunit2 3
RPB71 2 3     RNA Polymerase II Subunit B72 3
HRPB191     DNA Directed RNA Polymerase II 19 Kda Polypeptide2
HsRPB71     DNA-Directed RNA Polymerase II 19 KDa Polypeptide2
RPB192 3     DNA-Directed RNA Polymerase II Subunit RPB72
DNA-Directed RNA Polymerase II Subunit G2 3     RNA Polymerase II Seventh Subunit2

External Ids:    HGNC: 91941   Entrez Gene: 54362   Ensembl: ENSG000001680027   OMIM: 6020135   UniProtKB: P624873   
ORGUL members:         
NONCODE:n341043    

Export aliases for POLR2G gene to outside databases

Previous GC identifers: GC11P065041 GC11P064104 GC11P062779 GC11P062304 GC11P062285 GC11P058857


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POLR2G:
This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing
messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize
transcribing polyermase molecules during elongation. (provided by RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: RPB7_HUMAN, P62487
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional
non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is
composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a
pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the
clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site cleft. The
RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA

Gene Wiki entry for POLR2G


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POLR2G gene promoter:
         ER-alpha   p53   MyoD   FOXD1   E2F-2   XBP-1   E2F-1   E2F   ZIC2/Zic2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOLR2G promoter sequence
   Search SABiosciences Chromatin IP Primers for POLR2G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLR2G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q13.1

POLR2G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR2G gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P062529:  view genomic region     (about GC identifiers)

Start:
62,529,011 bp from pter      End:
62,534,187 bp from pter
Size:
5,177 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RPB7_HUMAN, P62487 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase II subunit RPB7  
Size: 172 amino acids; 19294 Da
Subunit: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex
that protrudes from the 10-subunit Pol II core complex
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for POLR2G:
2C35 (3D)    
Secondary accessions: B2R5C0 P52433 Q2M1Z4

Explore the universe of human proteins at neXtProt for POLR2G: NX_P62487

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P62487

  • POLR2G Protein expression data from MOPED and PaxDb:    About this image 
    POLR2G Protein Expression
    REFSEQ proteins: NP_002687.1  
    ENSEMBL proteins: 
     ENSP00000301788   ENSP00000432198   ENSP00000433529   ENSP00000431624   ENSP00000433877  
     ENSP00000435669  
    Reactome Protein details: P62487
    Human Recombinant Protein Products for POLR2G: 
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    Novus Biologicals POLR2G Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for POLR2G

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9852112
    GO:0005654nucleoplasm TAS--
    GO:0005665DNA-directed RNA polymerase II, core complex IDA9852112

    POLR2G for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    POLR2G for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR003029 Rbsml_prot_S1_RNA-bd_dom
     IPR005576 RNA_pol_Rpb7_N
     IPR012340 NA-bd_OB-fold
     IPR022967 RNA-binding_domain_S1

    Graphical View of Domain Structure for InterPro Entry P62487

    ProtoNet protein and cluster: P62487

    UniProtKB/Swiss-Prot: RPB7_HUMAN, P62487
    Similarity: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPB7_HUMAN, P62487
    Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
    triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional
    non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is
    composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a
    pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the
    clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site cleft. The
    RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA

         Genatlas biochemistry entry for POLR2G:
    polymerase II,RNA (DNA dependent,polypeptide G,expressed in retina,brain,kidney,closely linked to D11S1765)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0003899DNA-directed RNA polymerase activity IEA--
    GO:0004672contributes to protein kinase activity IDA9852112
         
    POLR2G for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for POLR2G:
     Elongated cells  Upregulation of Wnt/beta-caten  Wnt reporter downregulated 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for POLR2G 

    miRNA
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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2G


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/15 super-pathways (see all 15About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Formation of RNA Pol II elongation complex
    8/35 pathways (see all 35)
    RNA Polymerase II Transcription Elongation1.00
    RNA Pol II CTD phosphorylation and interaction with CE0.55
    Formation of HIV-1 elongation complex in the absence of HIV-1 Tat1.00
    Dual incision reaction in TC-NER0.46
    Formation of RNA Pol II elongation complex 1.00
    Formation of transcription-coupled NER (TC-NER) repair complex0.46
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.98
    Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition0.40
    2mRNA Splicing - Major Pathway
    mRNA Splicing1.00
    mRNA Processing0.82
    mRNA Splicing - Major Pathway1.00
    mRNA Splicing - Minor Pathway0.40
    Processing of Capped Intron-Containing Pre-mRNA0.96
    3HIV Infection
    HIV Infection1.00
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes0.28
    Transcription_Ligand-Dependent Transcription of Retinoid-Target genes0.28
    4Nucleotide Excision Repair
    Nucleotide Excision Repair1.00
    DNA Repair0.46
    Transcription-coupled NER (TC-NER)0.90
    5Late Phase of HIV Life Cycle
    Late Phase of HIV Life Cycle1.00
    HIV Life Cycle0.90

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for POLR2G
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    DNA damage Role of Brca1 and Brca2 in DNA repair
    ATP/ITP metabolism

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POLR2G
        Assembly of RNA Polymerase-II Initiation Complex
    Transcription of mRNA

    3 GeneGo (Thomson Reuters) Pathways for POLR2G
        DNA damage Role of Brca1 and Brca2 in DNA repair
    ATP/ITP metabolism
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for POLR2G 
        Eukaryotic Transcription Initiation

    5/49        Reactome Pathways for POLR2G (see all 49)
        Tat-mediated HIV-1 elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    mRNA Splicing
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    Addition of the fourth nucleotide on the Nascent Transcript: Second Transition


    5         Kegg Pathways  (Kegg details for POLR2G):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways
    RNA polymerase
    Huntington's disease


    POLR2G for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POLR2G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/268 Interacting proteins for POLR2G (P624872, 3 ENSP000003017884) via UniProtKB, MINT, STRING, and/or I2D (see all 268)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK19P498422, 3, ENSP000003644824MINT-62582 MINT-62756 MINT-62680 I2D: score=5 STRING: ENSP00000364482
    EIF3CQ996133, ENSP000003326044I2D: score=2 STRING: ENSP00000332604
    EIF3CLQ996133, ENSP000003702584I2D: score=2 STRING: ENSP00000370258
    POLR2JP524353, ENSP000002926144I2D: score=7 STRING: ENSP00000292614
    POLR2IP369543, ENSP000002218594I2D: score=6 STRING: ENSP00000221859
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006281DNA repair TAS--
    GO:0006283transcription-coupled nucleotide-excision repair TAS--
    GO:0006289nucleotide-excision repair TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--

    POLR2G for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for POLR2G:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

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    Search CenterWatch for drugs/clinical trials and news about POLR2G / RPB7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POLR2G gene: 
    NM_002696.2  

    Unigene Cluster for POLR2G:

    Polymerase (RNA) II (DNA directed) polypeptide G
    Hs.14839  [show with all ESTs]
    Unigene Representative Sequence: BM919120
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301788(uc001nva.3) ENST00000533442 ENST00000525455 ENST00000524819
    ENST00000531944 ENST00000527435 ENST00000531996 ENST00000526368

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    Additional cDNA sequence: 

    AK312131.1 BC112162.1 BC112164.1 U20659.1 

    14 DOTS entries:

    DT.117130  DT.95324417  DT.95324419  DT.100662199  DT.95324422  DT.100740706  DT.120747586  DT.95324423 
    DT.100662198  DT.92365871  DT.95324420  DT.120747584  DT.120747651  DT.100662200 

    24/280 AceView cDNA sequences (see all 280):

    BU857161 BQ676946 AL550399 AI609711 BQ674622 CR607005 BU688192 BQ437558 
    BE796653 AI419458 AW328729 BM680767 BQ050722 BU162086 N56648 AA834069 
    AI202682 BU957283 BM704173 BE047713 BM467741 BU856940 BM272543 BE792887 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for POLR2G (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                          -                 -     -     -     -                                 
    SP2:                          -                       -     -     -                                 
    SP3:                          -                 -     -                 -                           
    SP4:                          -                 -     -     -     -     -                           
    SP5:                                            -     -     -     -                                 


    ECgene alternative splicing isoforms for POLR2G

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POLR2G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTACAAGACA
    POLR2G Expression
    About this image
    See POLR2G Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POLR2G

    SOURCE GeneReport for Unigene cluster: Hs.14839
        SABiosciences Custom PCR Arrays for POLR2G

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for POLR2G gene from 9/36 species (see all 36)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Polr2g1 , 5 polymerase (RNA) II (DNA directed) polypeptide G1, 5 90.31(n)1
    100(a)1
      19 (5.62 cM)5
    677101  NM_026329.21  NP_080605.11 
     87931295 
    lizard
    (Anolis carolinensis)
    Reptilia POLR2G6
    --
    96(a)
    1 ↔ 1
    GL343928.1(105389-113090)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW639912.12   -- 80.65(n)    AW639912.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc18d052 wufc18d05 81.14(n)   324088  BC045299.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rpb71 CG31155-PA 70.74(n)
    81.4(a)
      261631  NM_169622.2  NP_731983.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y54E10BR.63
    rpb-71
    Protein RPB-71 77(a)3
    70(n)1
    77.65(a)1
      I(3031339-3032939)3
    1718771  NM_058692.41  NP_491093.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPB7(YDR404C)4
    RPB71
    RNA polymerase II subunit B16; forms two subunit dissociable more4
    Rpb7p1
    49.11(n)1
    43.79(a)1
      4(1277169-1276654)4
    8520131, 4  NP_010692.31  NP_010692.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NRPB71 DNA-directed RNA polymerase II subunit RPB7 58.67(n)
    53.8(a)
      836036  NM_125308.3  NP_200726.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g04007001 hypothetical protein 61.01(n)
    53.22(a)
      4338726  NM_001062018.1  NP_001055483.1 


    ENSEMBL Gene Tree for POLR2G (if available)
    TreeFam Gene Tree for POLR2G (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/161 NCBI SNPs in POLR2G are shown (see all 161    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2021326621,2
    --62527064(+) TCCAA-/TTTTTT 1 -- us2k10--------
    rs25105371,2
    --62527179(+) cctctG/Ttagta 1 -- us2k10--------
    rs25105381,2
    --62527180(+) ctcttG/Tagtag 1 -- us2k10--------
    rs1497825441,2
    --62527250(+) GGGTTA/TTCACT 1 -- us2k10--------
    rs1457068901,2
    --62527417(+) GATCAC/TCTGAG 1 -- us2k10--------
    rs612970471,2
    F--62527563(+) CTTCCC/TGGGTT 1 -- us2k11Minor allele frequency- T:0.06EA 120
    rs1174266331,2
    --62527599(+) CCCAGT/CAGCCG 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs357308431,2
    C,F,H--62527634(+) CCACCA/CGTGCC 1 -- us2k119Minor allele frequency- C:0.19NS EA NA WA CSA 2219
    rs24676481,2
    C--62527855(-) AAAAAA/TTTTAA 1 -- us2k1 trp30--------
    rs1817684541,2
    --62527944(+) CTCCCA/GGGTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for POLR2G (62529011 - 62534187 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for POLR2G
         1 CNV: 0150

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POLR2G
    DNA2.0 Custom Variant and Variant Library Synthesis for POLR2G

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    POLR2G for disorders           About GeneDecksing

    OMIM gene information: 602013    OMIM disorders: --

    8 diseases for POLR2G:    About MalaCards
    ovarian endometriosis    endometriosis    adenocarcinoma in situ    huntington's disease
    conjunctivitis    immunodeficiency    adenocarcinoma    malaria


    Export disorders for POLR2G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POLR2G gene, integrated from 9 sources (see all 113):
    (articles sorted by number of sources associating them with POLR2G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology. (PubMed id 7579693)1, 2, 3, 9 Khazak V.... Golemis E.A. (1995)
    2. Human gene for the RNA polymerase II seventh subunit (hsRPB7): structure, expression and chromosomal localization. (PubMed id 9256063)1, 2, 3 Schoen T.J.... Rodriguez I.R. (1997)
    3. Crystal structure and RNA binding of the Rpb4/Rpb7 subunits of human RNA polymerase II. (PubMed id 16282592)1, 2 Meka H.... Brick P. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PubMed id 9852112)1, 2 Kershnar E.... Chiang C.-M. (1998)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    9. Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development. (PubMed id 22422068)1 Dahiya S....Wigdahl B. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5436 HGNC: 9194 AceView: POLR2G Ensembl:ENSG00000168002 euGenes: HUgn5436
    ECgene: POLR2G Kegg: 5436 H-InvDB: POLR2G

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POLR2G Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for POLR2G Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for POLR2G gene:
    Search GeneIP for patents involving POLR2G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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