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Aliases for POLR2G Gene

Aliases for POLR2G Gene

  • RNA Polymerase II Subunit G 2 3 5
  • Polymerase (RNA) II (DNA Directed) Polypeptide G 2 3
  • DNA-Directed RNA Polymerase II Subunit G 3 4
  • RNA Polymerase II 19 KDa Subunit 3 4
  • RNA Polymerase II Subunit B7 3 4
  • RPB19 3 4
  • RPB7 3 4
  • DNA Directed RNA Polymerase II 19 Kda Polypeptide 3
  • DNA-Directed RNA Polymerase II 19 KDa Polypeptide 3
  • DNA-Directed RNA Polymerase II Subunit RPB7 3
  • RNA Polymerase II Seventh Subunit 3
  • Polymerase (RNA) II Subunit G 3
  • HRPB19 3
  • HsRPB7 3

External Ids for POLR2G Gene

Previous GeneCards Identifiers for POLR2G Gene

  • GC11P065041
  • GC11P064104
  • GC11P062779
  • GC11P062304
  • GC11P062285
  • GC11P062529
  • GC11P058857

Summaries for POLR2G Gene

Entrez Gene Summary for POLR2G Gene

  • This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing polyermase molecules during elongation. [provided by RefSeq, Jan 2009]

GeneCards Summary for POLR2G Gene

POLR2G (RNA Polymerase II Subunit G) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and mRNA Capping. GO annotations related to this gene include nucleic acid binding and single-stranded RNA binding.

UniProtKB/Swiss-Prot for POLR2G Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA.

Gene Wiki entry for POLR2G Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2G Gene

Genomics for POLR2G Gene

Regulatory Elements for POLR2G Gene

Enhancers for POLR2G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F062712 0.9 ENCODE 11.5 -47.6 -47614 3.5 ELF3 RAD21 YY1 CREM CEBPB PPARG NR2F2 ETV4 CEBPA ZBTB33 TTC9C UBXN1 LBHD1 LRRN4CL POLR2G GANAB B3GAT3 EML3 ROM1 UQCC3
GH11F062694 0.9 ENCODE 10.7 -66.7 -66675 1.1 HDGF HDAC1 PKNOX1 SIN3A PTRF RAD21 ZNF143 CREM EGR2 ZNF654 BSCL2 TTC9C LBHD1 ENSG00000255432 METTL12 SNORA57 INTS5 GANAB UQCC3 EML3
GH11F061826 1.5 FANTOM5 ENCODE 4.8 -929.2 -929170 12.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A YY1 ZNF143 FOS FADS2 INTS5 NXF1 UBXN1 METTL12 MTA2 FADS1 TMEM138 EML3 TMEM109
GH11F061841 1.1 ENCODE 4.9 -919.2 -919232 1.6 PKNOX1 ARNT MLX ARID4B DMAP1 SLC30A9 SP5 NFYC SMARCB1 KAT8 FADS2 INTS5 TMEM109 NXF1 UBXN1 FADS3 METTL12 CD5 EEF1G VPS37C
GH11F061845 0.5 ENCODE 4.9 -915.5 -915511 1.5 ZFHX2 POLR2A EGR2 FADS2 FADS3 RAB3IL1 POLR2G MIR1908 FADS1 MIR6746
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLR2G on UCSC Golden Path with GeneCards custom track

Promoters for POLR2G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000563368 161 1401 WRNIP1 ARID4B SIN3A ZNF121 ELK1 GATA2 SP3 SP5 NFYC NCOA1

Genomic Location for POLR2G Gene

Chromosome:
11
Start:
62,761,539 bp from pter
End:
62,766,715 bp from pter
Size:
5,177 bases
Orientation:
Plus strand

Genomic View for POLR2G Gene

Genes around POLR2G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2G Gene

Proteins for POLR2G Gene

  • Protein details for POLR2G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62487-RPB7_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB7
    Protein Accession:
    P62487
    Secondary Accessions:
    • B2R5C0
    • P52433
    • Q2M1Z4

    Protein attributes for POLR2G Gene

    Size:
    172 amino acids
    Molecular mass:
    19294 Da
    Quaternary structure:
    • Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.

    Three dimensional structures from OCA and Proteopedia for POLR2G Gene

neXtProt entry for POLR2G Gene

Post-translational modifications for POLR2G Gene

  • Ubiquitination at Lys 27, Lys 71, and Lys 81
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR2G Gene

No data available for DME Specific Peptides for POLR2G Gene

Domains & Families for POLR2G Gene

Gene Families for POLR2G Gene

Protein Domains for POLR2G Gene

Suggested Antigen Peptide Sequences for POLR2G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62487

UniProtKB/Swiss-Prot:

RPB7_HUMAN :
  • Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
Family:
  • Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2G: view

Function for POLR2G Gene

Molecular function for POLR2G Gene

GENATLAS Biochemistry:
polymerase II,RNA (DNA dependent,polypeptide G,expressed in retina,brain,kidney,closely linked to D11S1765)
UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA.

Gene Ontology (GO) - Molecular Function for POLR2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003697 single-stranded DNA binding IBA --
GO:0003723 RNA binding IEA --
GO:0003727 single-stranded RNA binding IBA --
GO:0003899 contributes_to DNA-directed RNA polymerase activity IEA,IBA --
genes like me logo Genes that share ontologies with POLR2G: view
genes like me logo Genes that share phenotypes with POLR2G: view

Animal Model Products

miRNA for POLR2G Gene

miRTarBase miRNAs that target POLR2G

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2G Gene

Localization for POLR2G Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2G Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR2G gene
Compartment Confidence
nucleus 5
cytoskeleton 3
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for POLR2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IBA --
GO:0005634 nucleus IEA,IDA 9852112
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex IDA 9852112
genes like me logo Genes that share ontologies with POLR2G: view

Pathways & Interactions for POLR2G Gene

SuperPathways for POLR2G Gene

SuperPathway Contained pathways
1 Formation of HIV elongation complex in the absence of HIV Tat
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 mRNA Capping
4 HIV Life Cycle
.45
5 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
genes like me logo Genes that share pathways with POLR2G: view

Gene Ontology (GO) - Biological Process for POLR2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic IBA --
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with POLR2G: view

No data available for SIGNOR curated interactions for POLR2G Gene

Drugs & Compounds for POLR2G Gene

(4) Drugs for POLR2G Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0

(1) Additional Compounds for POLR2G Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with POLR2G: view

Transcripts for POLR2G Gene

Unigene Clusters for POLR2G Gene

Polymerase (RNA) II (DNA directed) polypeptide G:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2G Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: -

Relevant External Links for POLR2G Gene

GeneLoc Exon Structure for
POLR2G
ECgene alternative splicing isoforms for
POLR2G

Expression for POLR2G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POLR2G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR2G Gene

This gene is overexpressed in Tlymphocyte (24.9) and Peripheral blood mononuclear cells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POLR2G Gene



Protein tissue co-expression partners for POLR2G Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLR2G Gene:

POLR2G

SOURCE GeneReport for Unigene cluster for POLR2G Gene:

Hs.14839
genes like me logo Genes that share expression patterns with POLR2G: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLR2G Gene

Orthologs for POLR2G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR2G 34 35
  • 100 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia POLR2G 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLR2G 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR2G 34 35
  • 94.96 (n)
cow
(Bos Taurus)
Mammalia POLR2G 34 35
  • 93.22 (n)
rat
(Rattus norvegicus)
Mammalia Polr2g 34
  • 90.89 (n)
mouse
(Mus musculus)
Mammalia Polr2g 34 16 35
  • 90.31 (n)
lizard
(Anolis carolinensis)
Reptilia POLR2G 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2g 34
  • 80.62 (n)
zebrafish
(Danio rerio)
Actinopterygii polr2gl 34 35
  • 80.81 (n)
wufc18d05 34
fruit fly
(Drosophila melanogaster)
Insecta Rpb7 34 35
  • 70.74 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002121 34
  • 70.54 (n)
worm
(Caenorhabditis elegans)
Secernentea Y54E10BR.6 36
  • 77 (a)
rpb-7 34 35
  • 69.19 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR402C 34
  • 52.66 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C06787g 34
  • 50.49 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB7 34 35 37
  • 49.11 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPB7 34
  • 58.67 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4671 34
rice
(Oryza sativa)
Liliopsida Os05g0400700 34
  • 61.01 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7943 35
  • 88 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb7 34
  • 57.68 (n)
Species where no ortholog for POLR2G was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR2G Gene

ENSEMBL:
Gene Tree for POLR2G (if available)
TreeFam:
Gene Tree for POLR2G (if available)

Paralogs for POLR2G Gene

No data available for Paralogs for POLR2G Gene

Variants for POLR2G Gene

Sequence variations from dbSNP and Humsavar for POLR2G Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1045097 -- 62,766,575(+) GTCCA(A/G)AGGTC utr-variant-3-prime
rs1045122 -- 62,766,633(+) GGCAT(C/T)TGGTG utr-variant-3-prime
rs1045125 -- 62,766,642(+) TGCTT(C/T)TTGTA utr-variant-3-prime
rs1045183 -- 62,766,684(+) GTGTT(C/T)TAAGT utr-variant-3-prime
rs111270567 -- 62,761,654(+) ATGTT(A/C)TACCA reference, missense

Variation tolerance for POLR2G Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR2G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR2G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for POLR2G Gene

Disorders for POLR2G Gene

Relevant External Links for POLR2G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2G

No disorders were found for POLR2G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR2G Gene

Publications for POLR2G Gene

  1. Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology. (PMID: 7579693) Khazak V. … Golemis E.A. (Mol. Biol. Cell 1995) 2 3 4 22 64
  2. Human gene for the RNA polymerase II seventh subunit (hsRPB7): structure, expression and chromosomal localization. (PMID: 9256063) Schoen T.J. … Rodriguez I.R. (Biochim. Biophys. Acta 1997) 2 3 4 64
  3. Crystal structure and RNA binding of the Rpb4/Rpb7 subunits of human RNA polymerase II. (PMID: 16282592) Meka H. … Brick P. (Nucleic Acids Res. 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PMID: 9852112) Kershnar E. … Chiang C.-M. (J. Biol. Chem. 1998) 3 4 64

Products for POLR2G Gene

Sources for POLR2G Gene

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