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Aliases for POLR2F Gene

Aliases for POLR2F Gene

  • RNA Polymerase II Subunit F 2 3 5
  • DNA-Directed RNA Polymerases I, II, And III 14.4 KDa Polypeptide 3 4
  • Polymerase (RNA) II (DNA Directed) Polypeptide F 2 3
  • RNA Polymerases I, II, And III Subunit ABC2 3 4
  • DNA-Directed RNA Polymerase II Subunit F 3 4
  • RPABC14.4 3 4
  • RPB14.4 3 4
  • POLRF 3 4
  • RPC15 3 4
  • DNA-Directed RNA Polymerases I, II, And III Subunit RPABC2 3
  • DNA Directed RNA Polymerase II 14.4 Kda Polypeptide 2
  • RNA Polymerase II Subunit 14.4 KD 3
  • Polymerase (RNA) II Subunit F 3
  • RPB6 Homolog 4
  • HRBP14.4 3
  • RPABC2 3
  • RPB6 3

External Ids for POLR2F Gene

Previous GeneCards Identifiers for POLR2F Gene

  • GC22P034964
  • GC22P036592
  • GC22P036674
  • GC22P038348
  • GC22P021315

Summaries for POLR2F Gene

Entrez Gene Summary for POLR2F Gene

  • This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for POLR2F Gene

POLR2F (RNA Polymerase II Subunit F) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Formation of HIV elongation complex in the absence of HIV Tat. Gene Ontology (GO) annotations related to this gene include DNA-directed 5-3 RNA polymerase activity and RNA polymerase I activity.

UniProtKB/Swiss-Prot for POLR2F Gene

  • DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).

Gene Wiki entry for POLR2F Gene

Additional gene information for POLR2F Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2F Gene

Genomics for POLR2F Gene

GeneHancer (GH) Regulatory Elements for POLR2F Gene

Promoters and enhancers for POLR2F Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I037952 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +1.3 1251 2.4 ATF1 MLX ARID4B SIN3A ZNF48 ETS1 POLR2B ELK1 ZNF143 MXD4 C22orf23 POLR2F ENSG00000279010 MIR6820
GH22I037956 Promoter 1 EPDnew 550.8 +3.5 3456 0.1 TFAP4 FOXA2 SAP130 ARID4B ZNF384 ZNF48 RARA NR2F6 CREM MIXL1 POLR2F C22orf23 ENSG00000279010 MIR6820
GH22I037951 Enhancer 0.6 ENCODE 550.8 -1.2 -1212 0.5 ZNF335 CTCF ATF1 PHF20 MTA1 CREB1 ZNF384 RAD21 CREM ENSG00000272582 POLR2F SOX10 RNU6-900P H1F0 GCAT C22orf23 ENSG00000279010
GH22I038174 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 +226.2 226202 8.7 MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 MCM3 SP3 PLA2G6 DDX17 MAFF ENSG00000228274 CSNK1E ANKRD54 CBY1 ENSG00000230912 GGA1 TMEM184B
GH22I038308 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 +361.6 361630 11.9 HDGF PKNOX1 SMAD1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 CSNK1E TMEM184B PICK1 MAFF KCNJ4 KDELR3 POLR2F SOX10 PDXP GGA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around POLR2F on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the POLR2F gene promoter:

Genomic Locations for POLR2F Gene

Genomic Locations for POLR2F Gene
chr22:37,952,607-38,041,915
(GRCh38/hg38)
Size:
89,309 bases
Orientation:
Plus strand
chr22:38,348,614-38,437,922
(GRCh37/hg19)

Genomic View for POLR2F Gene

Genes around POLR2F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2F Gene

Proteins for POLR2F Gene

  • Protein details for POLR2F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61218-RPAB2_HUMAN
    Recommended name:
    DNA-directed RNA polymerases I, II, and III subunit RPABC2
    Protein Accession:
    P61218
    Secondary Accessions:
    • P41584
    • Q6IAY3

    Protein attributes for POLR2F Gene

    Size:
    127 amino acids
    Molecular mass:
    14478 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.

    Three dimensional structures from OCA and Proteopedia for POLR2F Gene

neXtProt entry for POLR2F Gene

Post-translational modifications for POLR2F Gene

  • Ubiquitination at isoforms=59 and Lys101

No data available for DME Specific Peptides for POLR2F Gene

Domains & Families for POLR2F Gene

Gene Families for POLR2F Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for POLR2F Gene

Graphical View of Domain Structure for InterPro Entry

P61218

UniProtKB/Swiss-Prot:

RPAB2_HUMAN :
  • Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family.
Family:
  • Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2F: view

Function for POLR2F Gene

Molecular function for POLR2F Gene

GENATLAS Biochemistry:
polymerase II,RNA (DNA directed),small polypeptide F(14.4kDa)
UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).

Phenotypes From GWAS Catalog for POLR2F Gene

Gene Ontology (GO) - Molecular Function for POLR2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001054 contributes_to RNA polymerase I activity IBA --
GO:0001055 contributes_to RNA polymerase II activity IBA --
GO:0001056 contributes_to RNA polymerase III activity IBA --
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed 5-3 RNA polymerase activity IEA --
genes like me logo Genes that share ontologies with POLR2F: view
genes like me logo Genes that share phenotypes with POLR2F: view

Animal Model Products

CRISPR Products

miRNA for POLR2F Gene

miRTarBase miRNAs that target POLR2F

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2F Gene

Localization for POLR2F Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2F Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR2F gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (4)
  • Nucleus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for POLR2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA 9852112
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex IDA,IEA 9852112
GO:0005666 DNA-directed RNA polymerase III complex IBA --
genes like me logo Genes that share ontologies with POLR2F: view

Pathways & Interactions for POLR2F Gene

SuperPathways for POLR2F Gene

SuperPathway Contained pathways
1 Formation of HIV elongation complex in the absence of HIV Tat
2 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
3 RNA Polymerase II Transcription Initiation And Promoter Clearance
4 RNA Polymerase III Transcription Initiation
5 mRNA Capping
genes like me logo Genes that share pathways with POLR2F: view

Gene Ontology (GO) - Biological Process for POLR2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated TAS,IEA --
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
GO:0006362 transcription elongation from RNA polymerase I promoter TAS --
genes like me logo Genes that share ontologies with POLR2F: view

No data available for SIGNOR curated interactions for POLR2F Gene

Drugs & Compounds for POLR2F Gene

(6) Drugs for POLR2F Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist 0
PSI-6206 Pharma Inhibitor of HCV RNA polymerase,potent and selective 0

(1) Additional Compounds for POLR2F Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8

(2) ApexBio Compounds for POLR2F Gene

Compound Action Cas Number
PSI-6206 Inhibitor of HCV RNA polymerase,potent and selective 863329-66-2
PSI-7977 Antiviral agents for chronic HCV infection 1190307-88-0
genes like me logo Genes that share compounds with POLR2F: view

Drug Products

Transcripts for POLR2F Gene

Unigene Clusters for POLR2F Gene

Polymerase (RNA) II (DNA directed) polypeptide F:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2F Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: -
SP7: - -

Relevant External Links for POLR2F Gene

GeneLoc Exon Structure for
POLR2F
ECgene alternative splicing isoforms for
POLR2F

Expression for POLR2F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR2F Gene

Protein differential expression in normal tissues from HIPED for POLR2F Gene

This gene is overexpressed in Pancreas (27.2), CD8 Tcells (9.8), and Uterus (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POLR2F Gene



NURSA nuclear receptor signaling pathways regulating expression of POLR2F Gene:

POLR2F

SOURCE GeneReport for Unigene cluster for POLR2F Gene:

Hs.436578

Evidence on tissue expression from TISSUES for POLR2F Gene

  • Liver(4.3)
  • Nervous system(4.3)
  • Muscle(2)
genes like me logo Genes that share expression patterns with POLR2F: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR2F Gene

Orthologs for POLR2F Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR2F 33 34
  • 99.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia POLR2F 34
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLR2F 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR2F 33 34
  • 92.91 (n)
cow
(Bos Taurus)
Mammalia POLR2F 33 34
  • 92.13 (n)
rat
(Rattus norvegicus)
Mammalia Polr2f 33
  • 90.81 (n)
mouse
(Mus musculus)
Mammalia Polr2f 33 16 34
  • 89.5 (n)
chicken
(Gallus gallus)
Aves RPB6 34
  • 97 (a)
OneToOne
POLR2F 33
  • 83.99 (n)
lizard
(Anolis carolinensis)
Reptilia POLR2F 34
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2f 33
  • 82.41 (n)
Str.6446 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8852 33
zebrafish
(Danio rerio)
Actinopterygii polr2f 33 34
  • 79 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6027 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005873 33
  • 70 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpII18 35 33 34
  • 68.69 (n)
worm
(Caenorhabditis elegans)
Secernentea C06A1.5 35
  • 79 (a)
rpb-6 33 34
  • 62.37 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPO26 34
  • 46 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPB6B 33
  • 64.47 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7968 33
rice
(Oryza sativa)
Liliopsida Os03g0586600 33
  • 67.45 (n)
corn
(Zea mays)
Liliopsida Zm.16590 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8576 33
Species where no ortholog for POLR2F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR2F Gene

ENSEMBL:
Gene Tree for POLR2F (if available)
TreeFam:
Gene Tree for POLR2F (if available)

Paralogs for POLR2F Gene

No data available for Paralogs for POLR2F Gene

Variants for POLR2F Gene

Sequence variations from dbSNP and Humsavar for POLR2F Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1057518656 likely-pathogenic, Waardenburg syndrome type 2E 37,983,469(+) G/C genic_downstream_transcript_variant, intron_variant
rs121909117 pathogenic, Waardenburg syndrome type 4C 37,978,094(+) G/A genic_downstream_transcript_variant, intron_variant
rs139883 benign, Waardenburg syndrome, PCWH Syndrome 37,973,020(+) C/T genic_downstream_transcript_variant, intron_variant
rs139884 benign, not specified, Waardenburg syndrome, PCWH Syndrome 37,973,969(+) A/G genic_downstream_transcript_variant, intron_variant
rs149435516 benign, likely-benign, not specified, Waardenburg syndrome, PCWH Syndrome 37,983,767(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for POLR2F Gene

Variant ID Type Subtype PubMed ID
esv3568391 CNV loss 25503493
esv3647723 CNV loss 21293372
esv3647724 CNV gain 21293372
nsv471198 CNV loss 18288195
nsv473594 CNV novel sequence insertion 20440878
nsv834193 CNV loss 17160897

Variation tolerance for POLR2F Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POLR2F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR2F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2F Gene

Disorders for POLR2F Gene

Additional Disease Information for POLR2F

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for POLR2F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR2F Gene

Publications for POLR2F Gene

  1. Genomic structure of the RNA polymerase II small subunit (hRPB14.4) locus (POLRF) and mapping to 22q13.1 by sequence identity. (PMID: 8786150) Pusch C … Blin N (Genomics 1996) 2 3 4 22 58
  2. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PMID: 19237606) Michiels S … Benhamou S (Carcinogenesis 2009) 3 44 58
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Isolation and characterization of monoclonal antibodies directed against subunits of human RNA polymerases I, II, and III. (PMID: 10623476) Jones E … Cook PR (Experimental cell research 2000) 3 22 58

Products for POLR2F Gene

Sources for POLR2F Gene

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