Free for academic non-profit institutions. Other users need a Commercial license

Aliases for POLR2F Gene

Aliases for POLR2F Gene

  • Polymerase (RNA) II (DNA Directed) Polypeptide F 2 3
  • DNA-Directed RNA Polymerases I, II, And III 14.4 KDa Polypeptide 3 4
  • RNA Polymerases I, II, And III Subunit ABC2 3 4
  • DNA-Directed RNA Polymerase II Subunit F 3 4
  • RPABC14.4 3 4
  • RPB14.4 3 4
  • POLRF 3 4
  • RPC15 3 4
  • DNA Directed RNA Polymerase II 14.4 Kda Polypeptide 2
  • RNA Polymerase II Subunit 14.4 KD 3
  • RPB6 Homolog 4
  • HRBP14.4 3
  • RPABC2 3
  • RPB6 3

External Ids for POLR2F Gene

Previous GeneCards Identifiers for POLR2F Gene

  • GC22P034964
  • GC22P036592
  • GC22P036674
  • GC22P038348
  • GC22P021315

Summaries for POLR2F Gene

Entrez Gene Summary for POLR2F Gene

  • This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for POLR2F Gene

POLR2F (Polymerase (RNA) II (DNA Directed) Polypeptide F) is a Protein Coding gene. Among its related pathways are Immune System and Developmental Biology. GO annotations related to this gene include DNA-directed RNA polymerase activity and RNA polymerase I activity.

UniProtKB/Swiss-Prot for POLR2F Gene

  • DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).

Gene Wiki entry for POLR2F Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2F Gene

Genomics for POLR2F Gene

Regulatory Elements for POLR2F Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for POLR2F Gene

Chromosome:
22
Start:
37,952,607 bp from pter
End:
38,041,915 bp from pter
Size:
89,309 bases
Orientation:
Plus strand

Genomic View for POLR2F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POLR2F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2F Gene

Proteins for POLR2F Gene

  • Protein details for POLR2F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61218-RPAB2_HUMAN
    Recommended name:
    DNA-directed RNA polymerases I, II, and III subunit RPABC2
    Protein Accession:
    P61218
    Secondary Accessions:
    • P41584
    • Q6IAY3

    Protein attributes for POLR2F Gene

    Size:
    127 amino acids
    Molecular mass:
    14478 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.

    Three dimensional structures from OCA and Proteopedia for POLR2F Gene

neXtProt entry for POLR2F Gene

Proteomics data for POLR2F Gene at MOPED

Post-translational modifications for POLR2F Gene

  • Ubiquitination at Lys 59 and Lys 101
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for POLR2F Gene

Domains & Families for POLR2F Gene

Gene Families for POLR2F Gene

Protein Domains for POLR2F Gene

Suggested Antigen Peptide Sequences for POLR2F Gene

Graphical View of Domain Structure for InterPro Entry

P61218

UniProtKB/Swiss-Prot:

RPAB2_HUMAN :
  • Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family.
Family:
  • Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2F: view

Function for POLR2F Gene

Molecular function for POLR2F Gene

GENATLAS Biochemistry:
polymerase II,RNA (DNA directed),small polypeptide F(14.4kDa)
UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).

Gene Ontology (GO) - Molecular Function for POLR2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001054 contributes_to RNA polymerase I activity IBA --
GO:0001055 contributes_to RNA polymerase II activity IBA --
GO:0001056 contributes_to RNA polymerase III activity IBA --
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed RNA polymerase activity --
genes like me logo Genes that share ontologies with POLR2F: view
genes like me logo Genes that share phenotypes with POLR2F: view

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POLR2F

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2F Gene

Localization for POLR2F Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2F Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR2F Gene COMPARTMENTS Subcellular localization image for POLR2F gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for POLR2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9852112
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex IDA 9852112
GO:0005666 DNA-directed RNA polymerase III complex IBA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with POLR2F: view

Pathways & Interactions for POLR2F Gene

SuperPathways for POLR2F Gene

Superpath Contained pathways
1 Formation of the HIV-1 Early Elongation Complex
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 RNA Polymerase III Transcription Initiation
4 RNA Polymerase I Transcription
5 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
genes like me logo Genes that share pathways with POLR2F: view

Gene Ontology (GO) - Biological Process for POLR2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006289 nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated --
genes like me logo Genes that share ontologies with POLR2F: view

No data available for SIGNOR curated interactions for POLR2F Gene

Drugs & Compounds for POLR2F Gene

(7) Drugs for POLR2F Gene - From: HMDB and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with POLR2F: view

Transcripts for POLR2F Gene

Unigene Clusters for POLR2F Gene

Polymerase (RNA) II (DNA directed) polypeptide F:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POLR2F

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2F Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: -
SP7: - -

Relevant External Links for POLR2F Gene

GeneLoc Exon Structure for
POLR2F
ECgene alternative splicing isoforms for
POLR2F

Expression for POLR2F Gene

mRNA expression in normal human tissues for POLR2F Gene

Protein differential expression in normal tissues from HIPED for POLR2F Gene

This gene is overexpressed in Pancreas (27.2), CD8 Tcells (9.8), and Uterus (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POLR2F Gene



SOURCE GeneReport for Unigene cluster for POLR2F Gene Hs.436578

genes like me logo Genes that share expression patterns with POLR2F: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for POLR2F Gene

Orthologs for POLR2F Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2F Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POLR2F 35
  • 92.13 (n)
  • 100 (a)
POLR2F 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR2F 35
  • 92.91 (n)
  • 99.21 (a)
POLR2F 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr2f 35
  • 89.5 (n)
  • 99.21 (a)
Polr2f 16
Polr2f 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLR2F 35
  • 99.74 (n)
  • 100 (a)
POLR2F 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polr2f 35
  • 90.81 (n)
  • 99.21 (a)
oppossum
(Monodelphis domestica)
Mammalia POLR2F 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLR2F 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves POLR2F 35
  • 83.99 (n)
  • 97.64 (a)
RPB6 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLR2F 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2f 35
  • 82.41 (n)
  • 94.49 (a)
Str.6446 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8852 35
zebrafish
(Danio rerio)
Actinopterygii polr2f 35
  • 79 (n)
  • 87.4 (a)
polr2f 36
  • 87 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6027 35
fruit fly
(Drosophila melanogaster)
Insecta RpII18 37
  • 71 (a)
RpII18 35
  • 68.69 (n)
  • 73.74 (a)
RpII18 36
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005873 35
  • 70 (n)
  • 78 (a)
worm
(Caenorhabditis elegans)
Secernentea C06A1.5 37
  • 79 (a)
rpb-6 35
  • 62.37 (n)
  • 70.97 (a)
rpb-6 36
  • 58 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPO26 36
  • 46 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPB6B 35
  • 64.47 (n)
  • 73.63 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7968 35
rice
(Oryza sativa)
Liliopsida Os03g0586600 35
  • 67.45 (n)
  • 77.65 (a)
corn
(Zea mays)
Liliopsida Zm.16590 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8576 35
Species with no ortholog for POLR2F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR2F Gene

ENSEMBL:
Gene Tree for POLR2F (if available)
TreeFam:
Gene Tree for POLR2F (if available)

Paralogs for POLR2F Gene

No data available for Paralogs for POLR2F Gene

Variants for POLR2F Gene

Sequence variations from dbSNP and Humsavar for POLR2F Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs139862 -- 37,955,979(+) tgcac(C/T)cagct intron-variant
rs139863 -- 37,956,308(+) gctgg(C/T)cttga intron-variant
rs139864 -- 37,956,474(+) tacag(C/T)ggtgc intron-variant
rs139865 -- 37,957,925(+) CTGCC(C/G)CCTGC intron-variant
rs139866 -- 37,958,677(+) TCAAG(C/T)CTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR2F Gene

Variant ID Type Subtype PubMed ID
nsv915035 CNV Loss 21882294
nsv915053 CNV Loss 21882294

Variation tolerance for POLR2F Gene

Residual Variation Intolerance Score: 40.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR2F Gene

HapMap Linkage Disequilibrium report
POLR2F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2F Gene

Disorders for POLR2F Gene

Relevant External Links for POLR2F

Genetic Association Database (GAD)
POLR2F
Human Genome Epidemiology (HuGE) Navigator
POLR2F
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2F
genes like me logo Genes that share disorders with POLR2F: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR2F Gene

Publications for POLR2F Gene

  1. Genomic structure of the RNA polymerase II small subunit (hRPB14.4) locus (POLRF) and mapping to 22q13.1 by sequence identity. (PMID: 8786150) Pusch C. … Blin N. (Genomics 1996) 2 23 67
  2. Isolation and characterization of monoclonal antibodies directed against subunits of human RNA polymerases I, II, and III. (PMID: 10623476) Jones E. … Cook P.R. (Exp. Cell Res. 2000) 23 67
  3. Isolation and characterisation of a chick cDNA encoding the RNA polymerase common subunit RPB6. (PMID: 10902924) Kaarbo M. … Murrell W.G. (DNA Seq. 2000) 23 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for POLR2F Gene

Sources for POLR2F Gene

Back to Top

Content