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Aliases for POLR2F Gene

Aliases for POLR2F Gene

  • RNA Polymerase II Subunit F 2 3 5
  • DNA-Directed RNA Polymerases I, II, And III 14.4 KDa Polypeptide 3 4
  • Polymerase (RNA) II (DNA Directed) Polypeptide F 2 3
  • RNA Polymerases I, II, And III Subunit ABC2 3 4
  • DNA-Directed RNA Polymerase II Subunit F 3 4
  • RPABC14.4 3 4
  • RPB14.4 3 4
  • POLRF 3 4
  • RPC15 3 4
  • DNA-Directed RNA Polymerases I, II, And III Subunit RPABC2 3
  • DNA Directed RNA Polymerase II 14.4 Kda Polypeptide 2
  • RNA Polymerase II Subunit 14.4 KD 3
  • Polymerase (RNA) II Subunit F 3
  • RPB6 Homolog 4
  • HRBP14.4 3
  • RPABC2 3
  • RPB6 3

External Ids for POLR2F Gene

Previous GeneCards Identifiers for POLR2F Gene

  • GC22P034964
  • GC22P036592
  • GC22P036674
  • GC22P038348
  • GC22P021315

Summaries for POLR2F Gene

Entrez Gene Summary for POLR2F Gene

  • This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for POLR2F Gene

POLR2F (RNA Polymerase II Subunit F) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Formation of HIV elongation complex in the absence of HIV Tat. GO annotations related to this gene include DNA-directed 5-3 RNA polymerase activity and RNA polymerase I activity.

UniProtKB/Swiss-Prot for POLR2F Gene

  • DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).

Gene Wiki entry for POLR2F Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2F Gene

Genomics for POLR2F Gene

Regulatory Elements for POLR2F Gene

Enhancers for POLR2F Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G038032 2.1 VISTA Ensembl ENCODE dbSUPER 11.9 +81.6 81584 3.6 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 SOX10 POLR2F BAIAP2L2 ENSG00000222044 GC22P038026
GH22G038294 1.7 Ensembl ENCODE dbSUPER 10.8 +348.3 348336 12.5 CREB3L1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF416 ZNF263 SP3 TBX21 CBX7 ENSG00000230149 CBX6 ENSG00000273076 NPTXR TMEM184B ENSG00000272669 ENSG00000225450 APOBEC3D PRDX3P1
GH22G038309 1.8 FANTOM5 ENCODE dbSUPER 9.9 +361.6 361630 11.9 MLX CREB3L1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TMEM184B PICK1 MAFF KCNJ4 KDELR3 SOX10 POLR2F PDXP GGA1 SUN2
GH22G037886 1.3 ENCODE dbSUPER 10.4 -64.8 -64847 2.3 FOXA2 PKNOX1 MLX ARID4B SIN3A FEZF1 ZNF48 ZNF121 ELK1 FOS GALR3 ANKRD54 EIF3L MIR659 GCAT H1F0 POLR2F SOX10 GC22P037892 ENSG00000279738
GH22G038422 1.1 ENCODE dbSUPER 10.4 +471.3 471256 3.0 ZSCAN4 KLF17 FEZF1 BMI1 RARA ZNF366 ZSCAN5C SCRT2 ETV6 EGR2 CSNK1E KDELR3 LOC400927 KCNJ4 TAB1 CBY1 SOX10 POLR2F ENSG00000230912 ENSG00000228274
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLR2F on UCSC Golden Path with GeneCards custom track

Promoters for POLR2F Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000146093 237 1401 ATF1 MLX ARID4B SIN3A ZNF48 ETS1 ELK1 ZNF143 MXD4 ZNF518A

Genomic Location for POLR2F Gene

Chromosome:
22
Start:
37,952,607 bp from pter
End:
38,041,915 bp from pter
Size:
89,309 bases
Orientation:
Plus strand

Genomic View for POLR2F Gene

Genes around POLR2F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2F Gene

Proteins for POLR2F Gene

  • Protein details for POLR2F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61218-RPAB2_HUMAN
    Recommended name:
    DNA-directed RNA polymerases I, II, and III subunit RPABC2
    Protein Accession:
    P61218
    Secondary Accessions:
    • P41584
    • Q6IAY3

    Protein attributes for POLR2F Gene

    Size:
    127 amino acids
    Molecular mass:
    14478 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.

    Three dimensional structures from OCA and Proteopedia for POLR2F Gene

neXtProt entry for POLR2F Gene

Post-translational modifications for POLR2F Gene

  • Ubiquitination at posLast=5959 and Lys101
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for POLR2F Gene

Domains & Families for POLR2F Gene

Gene Families for POLR2F Gene

Suggested Antigen Peptide Sequences for POLR2F Gene

Graphical View of Domain Structure for InterPro Entry

P61218

UniProtKB/Swiss-Prot:

RPAB2_HUMAN :
  • Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family.
Family:
  • Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2F: view

Function for POLR2F Gene

Molecular function for POLR2F Gene

GENATLAS Biochemistry:
polymerase II,RNA (DNA directed),small polypeptide F(14.4kDa)
UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).

Gene Ontology (GO) - Molecular Function for POLR2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001054 contributes_to RNA polymerase I activity IBA --
GO:0001055 contributes_to RNA polymerase II activity IBA --
GO:0001056 contributes_to RNA polymerase III activity IBA --
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed 5-3 RNA polymerase activity IEA --
genes like me logo Genes that share ontologies with POLR2F: view
genes like me logo Genes that share phenotypes with POLR2F: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2F Gene

Localization for POLR2F Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2F Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR2F gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1

Gene Ontology (GO) - Cellular Components for POLR2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA 9852112
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex IDA,IEA 9852112
GO:0005666 DNA-directed RNA polymerase III complex IBA --
genes like me logo Genes that share ontologies with POLR2F: view

Pathways & Interactions for POLR2F Gene

SuperPathways for POLR2F Gene

SuperPathway Contained pathways
1 Formation of HIV elongation complex in the absence of HIV Tat
2 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
3 RNA Polymerase II Transcription Initiation And Promoter Clearance
4 RNA Polymerase III Transcription Initiation
5 mRNA Capping
genes like me logo Genes that share pathways with POLR2F: view

Gene Ontology (GO) - Biological Process for POLR2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated TAS,IEA --
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
GO:0006362 transcription elongation from RNA polymerase I promoter TAS --
genes like me logo Genes that share ontologies with POLR2F: view

No data available for SIGNOR curated interactions for POLR2F Gene

Drugs & Compounds for POLR2F Gene

(6) Drugs for POLR2F Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0
PSI-6206 Pharma Inhibitor of HCV RNA polymerase,potent and selective 0

(1) Additional Compounds for POLR2F Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8

(2) ApexBio Compounds for POLR2F Gene

Compound Action Cas Number
PSI-6206 Inhibitor of HCV RNA polymerase,potent and selective 863329-66-2
PSI-7977 Antiviral agents for chronic HCV infection 1190307-88-0
genes like me logo Genes that share compounds with POLR2F: view

Transcripts for POLR2F Gene

Unigene Clusters for POLR2F Gene

Polymerase (RNA) II (DNA directed) polypeptide F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2F Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: -
SP7: - -

Relevant External Links for POLR2F Gene

GeneLoc Exon Structure for
POLR2F
ECgene alternative splicing isoforms for
POLR2F

Expression for POLR2F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR2F Gene

Protein differential expression in normal tissues from HIPED for POLR2F Gene

This gene is overexpressed in Pancreas (27.2), CD8 Tcells (9.8), and Uterus (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POLR2F Gene



NURSA nuclear receptor signaling pathways regulating expression of POLR2F Gene:

POLR2F

SOURCE GeneReport for Unigene cluster for POLR2F Gene:

Hs.436578

Evidence on tissue expression from TISSUES for POLR2F Gene

  • Liver(4.3)
  • Nervous system(4.3)
  • Muscle(2)
genes like me logo Genes that share expression patterns with POLR2F: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR2F Gene

Orthologs for POLR2F Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR2F 34 35
  • 99.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia POLR2F 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLR2F 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR2F 34 35
  • 92.91 (n)
cow
(Bos Taurus)
Mammalia POLR2F 34 35
  • 92.13 (n)
rat
(Rattus norvegicus)
Mammalia Polr2f 34
  • 90.81 (n)
mouse
(Mus musculus)
Mammalia Polr2f 34 16 35
  • 89.5 (n)
chicken
(Gallus gallus)
Aves RPB6 35
  • 97 (a)
OneToOne
POLR2F 34
  • 83.99 (n)
lizard
(Anolis carolinensis)
Reptilia POLR2F 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2f 34
  • 82.41 (n)
Str.6446 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8852 34
zebrafish
(Danio rerio)
Actinopterygii polr2f 34 35
  • 79 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6027 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005873 34
  • 70 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpII18 36 34 35
  • 68.69 (n)
worm
(Caenorhabditis elegans)
Secernentea C06A1.5 36
  • 79 (a)
rpb-6 34 35
  • 62.37 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPO26 35
  • 46 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPB6B 34
  • 64.47 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7968 34
rice
(Oryza sativa)
Liliopsida Os03g0586600 34
  • 67.45 (n)
corn
(Zea mays)
Liliopsida Zm.16590 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8576 34
Species where no ortholog for POLR2F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR2F Gene

ENSEMBL:
Gene Tree for POLR2F (if available)
TreeFam:
Gene Tree for POLR2F (if available)

Paralogs for POLR2F Gene

No data available for Paralogs for POLR2F Gene

Variants for POLR2F Gene

Sequence variations from dbSNP and Humsavar for POLR2F Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_036571 A breast cancer sample
rs121909117 Pathogenic 37,978,094(-) GGAGG(C/T)TGAGC intron-variant, reference, missense
rs267607081 Pathogenic 37,978,043(-) GTACC(A/C)GCCCA intron-variant, reference, missense
rs281797260 Pathogenic 37,977,943(+) CTCTT(C/G)TAGTG intron-variant, reference, stop-gained
rs397515366 Pathogenic 37,978,081(-) CTCCG(-/GCTCCT)TATGC intron-variant, cds-indel

Structural Variations from Database of Genomic Variants (DGV) for POLR2F Gene

Variant ID Type Subtype PubMed ID
esv3568391 CNV loss 25503493
esv3647723 CNV loss 21293372
esv3647724 CNV gain 21293372
nsv471198 CNV loss 18288195
nsv473594 CNV novel sequence insertion 20440878
nsv834193 CNV loss 17160897

Variation tolerance for POLR2F Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR2F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR2F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2F Gene

Disorders for POLR2F Gene

Relevant External Links for POLR2F

Genetic Association Database (GAD)
POLR2F
Human Genome Epidemiology (HuGE) Navigator
POLR2F
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2F

No disorders were found for POLR2F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR2F Gene

Publications for POLR2F Gene

  1. Genomic structure of the RNA polymerase II small subunit (hRPB14.4) locus (POLRF) and mapping to 22q13.1 by sequence identity. (PMID: 8786150) Pusch C. … Blin N. (Genomics 1996) 2 3 4 22 64
  2. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PMID: 19237606) Michiels S. … Benhamou S. (Carcinogenesis 2009) 3 46 64
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Isolation and characterization of monoclonal antibodies directed against subunits of human RNA polymerases I, II, and III. (PMID: 10623476) Jones E. … Cook P.R. (Exp. Cell Res. 2000) 3 22 64

Products for POLR2F Gene

Sources for POLR2F Gene

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