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Aliases for POLR2E Gene

Aliases for POLR2E Gene

  • Polymerase (RNA) II Subunit E 2 3
  • Polymerase (RNA) II (DNA Directed) Polypeptide E, 25kDa 3 5
  • DNA Directed RNA Polymerase II 23 Kda Polypeptide 2 3
  • DNA-Directed RNA Polymerase II 23 KDa Polypeptide 3 4
  • RNA Polymerases I, II, And III Subunit ABC1 3 4
  • DNA-Directed RNA Polymerase II Subunit E 3 4
  • RPB5 Homolog 3 4
  • XAP4 3 4
  • Polymerase (RNA) II (DNA Directed) Polypeptide E (25kD) 2
  • DNA-Directed RNA Polymerase Subunit RPABC1 3
  • RPABC1 3
  • HRPB25 3
  • HsRPB5 3
  • RPB5 3

External Ids for POLR2E Gene

Previous GeneCards Identifiers for POLR2E Gene

  • GC19M001162
  • GC19M001027
  • GC19M001039
  • GC19M000860

Summaries for POLR2E Gene

Entrez Gene Summary for POLR2E Gene

  • This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

GeneCards Summary for POLR2E Gene

POLR2E (Polymerase (RNA) II Subunit E) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include DNA-directed RNA polymerase activity and RNA polymerase I activity.

UniProtKB/Swiss-Prot for POLR2E Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).

Gene Wiki entry for POLR2E Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2E Gene

Genomics for POLR2E Gene

Regulatory Elements for POLR2E Gene

Promoters for POLR2E Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POLR2E on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the POLR2E gene promoter:

Genomic Location for POLR2E Gene

Chromosome:
19
Start:
1,086,579 bp from pter
End:
1,095,392 bp from pter
Size:
8,814 bases
Orientation:
Minus strand

Genomic View for POLR2E Gene

Genes around POLR2E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2E Gene

Proteins for POLR2E Gene

  • Protein details for POLR2E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19388-RPAB1_HUMAN
    Recommended name:
    DNA-directed RNA polymerases I, II, and III subunit RPABC1
    Protein Accession:
    P19388
    Secondary Accessions:
    • B2R6L4
    • D6W5Y1
    • O43380
    • Q6PIH5
    • Q9BT06

    Protein attributes for POLR2E Gene

    Size:
    210 amino acids
    Molecular mass:
    24551 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively (By similarity). In RNA Pol II, this subunit is present in 2-fold molar excess over the other subunits. Interacts with URI1. Interacts with HBV protein X.

neXtProt entry for POLR2E Gene

Proteomics data for POLR2E Gene at MOPED

Post-translational modifications for POLR2E Gene

  • Ubiquitination at Lys 115
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for POLR2E Gene

Domains & Families for POLR2E Gene

Gene Families for POLR2E Gene

Suggested Antigen Peptide Sequences for POLR2E Gene

Graphical View of Domain Structure for InterPro Entry

P19388

UniProtKB/Swiss-Prot:

RPAB1_HUMAN :
  • Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.
Family:
  • Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2E: view

Function for POLR2E Gene

Molecular function for POLR2E Gene

GENATLAS Biochemistry:
polymerase II,RNA (DNA directed) small polypeptide E (25kDa)
UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).

Gene Ontology (GO) - Molecular Function for POLR2E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001054 contributes_to RNA polymerase I activity IBA --
genes like me logo Genes that share ontologies with POLR2E: view
genes like me logo Genes that share phenotypes with POLR2E: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2E Gene

Localization for POLR2E Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2E Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR2E Gene COMPARTMENTS Subcellular localization image for POLR2E gene
Compartment Confidence
cytosol 5
nucleus 5
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for POLR2E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR2E: view

Pathways & Interactions for POLR2E Gene

SuperPathways for POLR2E Gene

Superpath Contained pathways
1 Formation of the HIV-1 Early Elongation Complex
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
4 RNA Polymerase III Transcription Initiation
5 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
genes like me logo Genes that share pathways with POLR2E: view

Gene Ontology (GO) - Biological Process for POLR2E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006360 transcription from RNA polymerase I promoter TAS --
genes like me logo Genes that share ontologies with POLR2E: view

No data available for SIGNOR curated interactions for POLR2E Gene

Drugs & Compounds for POLR2E Gene

(5) Drugs for POLR2E Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with POLR2E: view

Transcripts for POLR2E Gene

Unigene Clusters for POLR2E Gene

Polymerase (RNA) II (DNA directed) polypeptide E, 25kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2E Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9
SP1: -
SP2: - - - - - - -
SP3:
SP4: - -
SP5: -
SP6: -
SP7: -
SP8:

Relevant External Links for POLR2E Gene

GeneLoc Exon Structure for
POLR2E
ECgene alternative splicing isoforms for
POLR2E

Expression for POLR2E Gene

mRNA expression in normal human tissues for POLR2E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR2E Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLR2E Gene



SOURCE GeneReport for Unigene cluster for POLR2E Gene Hs.24301

genes like me logo Genes that share expression patterns with POLR2E: view

Protein tissue co-expression partners for POLR2E Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLR2E Gene

Orthologs for POLR2E Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2E Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POLR2E 35
  • 92.06 (n)
  • 99.05 (a)
POLR2E 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR2E 35
  • 91.75 (n)
  • 97.62 (a)
POLR2E 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr2e 35
  • 90 (n)
  • 99.05 (a)
Polr2e 16
Polr2e 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLR2E 35
  • 99.66 (n)
  • 100 (a)
POLR2E 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polr2e 35
  • 90.32 (n)
  • 99.05 (a)
oppossum
(Monodelphis domestica)
Mammalia POLR2E 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves POLR2E 35
  • 87.62 (n)
  • 99.52 (a)
POLR2E 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2e 35
  • 79.84 (n)
  • 97.62 (a)
Str.471 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68604 35
zebrafish
(Danio rerio)
Actinopterygii polr2eb 35
  • 79.37 (n)
  • 94.76 (a)
POLR2E (2 of 2) 36
  • 92 (a)
OneToMany
polr2eb 36
  • 93 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10881 35
fruit fly
(Drosophila melanogaster)
Insecta Rpb5 37
  • 85 (a)
Rpb5 35
  • 77.35 (n)
  • 85.65 (a)
Rpb5 36
  • 85 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010064 35
  • 73.68 (n)
  • 85.65 (a)
worm
(Caenorhabditis elegans)
Secernentea H27M09.2 37
  • 77 (a)
rpb-5 36
  • 77 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER036W 35
  • 55.72 (n)
  • 49.25 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F21098g 35
  • 50.99 (n)
  • 48.02 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB5 35
  • 49.75 (n)
  • 47.26 (a)
RPB5 36
  • 42 (a)
OneToOne
RPB5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPB5 35
  • 56.37 (n)
  • 54.9 (a)
soybean
(Glycine max)
eudicotyledons Gma.10585 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3372 35
rice
(Oryza sativa)
Liliopsida Os01g0805800 35
  • 57.82 (n)
  • 54.59 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.22111 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2190 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05305 35
  • 52.05 (n)
  • 40.39 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb5 35
  • 48.35 (n)
  • 45.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 85 (a)
OneToOne
Species with no ortholog for POLR2E:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for POLR2E Gene

ENSEMBL:
Gene Tree for POLR2E (if available)
TreeFam:
Gene Tree for POLR2E (if available)

Paralogs for POLR2E Gene

Pseudogenes.org Pseudogenes for POLR2E Gene

genes like me logo Genes that share paralogs with POLR2E: view

No data available for Paralogs for POLR2E Gene

Variants for POLR2E Gene

Sequence variations from dbSNP and Humsavar for POLR2E Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12459404 - 1,094,005(+) CCCCA(A/C/G/T)ATTGG intron-variant, reference, missense
rs4921 -- 1,093,980(-) GGGCG(G/T)CCGCG intron-variant, reference, synonymous-codon
rs11959 -- 1,090,970(-) TGGCC(C/G)CCAAG reference, missense
rs12253 -- 1,088,640(-) CAGCT(C/G)TCACG utr-variant-3-prime
rs1609846 -- 1,096,530(+) TGACA(A/C)AGCTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for POLR2E Gene

Variant ID Type Subtype PubMed ID
dgv3513n71 CNV Loss 21882294
dgv3552n71 CNV Loss 21882294
nsv910292 CNV Loss 21882294
nsv910310 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
dgv3560n71 CNV Loss 21882294
nsv9662 CNV Gain 18304495
nsv469845 CNV Loss 16826518
essv258 CNV CNV 17122850
nsv833704 CNV Gain 17160897
dgv1055e1 CNV Complex 17122850
dgv3569n71 CNV Loss 21882294
dgv3574n71 CNV Loss 21882294
dgv3575n71 CNV Loss 21882294
nsv910401 CNV Loss 21882294
nsv470102 CNV Loss 18288195
dgv3578n71 CNV Loss 21882294
dgv3579n71 CNV Loss 21882294
nsv910412 CNV Loss 21882294
nsv910413 CNV Gain 21882294
dgv3580n71 CNV Loss 21882294
nsv470103 CNV Gain 18288195
nsv828366 CNV Loss 20364138

Variation tolerance for POLR2E Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR2E Gene

HapMap Linkage Disequilibrium report
POLR2E
Human Gene Mutation Database (HGMD)
POLR2E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2E Gene

Disorders for POLR2E Gene

Relevant External Links for POLR2E

Genetic Association Database (GAD)
POLR2E
Human Genome Epidemiology (HuGE) Navigator
POLR2E
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2E

No disorders were found for POLR2E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR2E Gene

Publications for POLR2E Gene

  1. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PMID: 19237606) Michiels S. … Benhamou S. (Carcinogenesis 2009) 3 48 67
  2. Mutational analysis of human RNA polymerase II subunit 5 (RPB5): the residues critical for interactions with TFIIF subunit RAP30 and hepatitis B virus X protein. (PMID: 16169872) Le T.T. … Murakami S. (J. Biochem. 2005) 3 23
  3. Chromosomal localization of human RNA polymerase II subunit genes. (PMID: 8034326) Acker J. … Kedinger C. (Genomics 1994) 2 3
  4. Long noncoding RNAs POLR2E rs3787016 C/T and HULC rs7763881 A/C polymorphisms are associated with decreased risk of esophageal cancer. (PMID: 25874495) Kang M. … Yin J. (Tumour Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for POLR2E Gene

Sources for POLR2E Gene

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