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Aliases for POLR2C Gene

Aliases for POLR2C Gene

  • Polymerase (RNA) II (DNA Directed) Polypeptide C, 33kDa 2 3
  • RNA Polymerase II Subunit 3 2 3 4
  • DNA-Directed RNA Polymerase II 33 KDa Polypeptide 3 4
  • DNA-Directed RNA Polymerase II Subunit C 3 4
  • RNA Polymerase II Subunit B3 3 4
  • RPB31 3 4
  • RPB33 3 4
  • Polymerase (RNA) II (DNA Directed) Polypeptide C (33kD) 2
  • DNA-Directed RNA Polymerase II Subunit RPB3 3
  • HRPB33 3
  • HsRPB3 3
  • RPB3 3

External Ids for POLR2C Gene

Summaries for POLR2C Gene

Entrez Gene Summary for POLR2C Gene

  • This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2C Gene

POLR2C (Polymerase (RNA) II (DNA Directed) Polypeptide C, 33kDa) is a Protein Coding gene. Diseases associated with POLR2C include hiv-1. Among its related pathways are Disease and GPCR Pathway. GO annotations related to this gene include protein dimerization activity and RNA polymerase II activity.

UniProtKB/Swiss-Prot for POLR2C Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity).

Gene Wiki entry for POLR2C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2C Gene

Genomics for POLR2C Gene

Genomic Location for POLR2C Gene

Start:
57,462,387 bp from pter
End:
57,472,010 bp from pter
Size:
9,624 bases
Orientation:
Plus strand

Genomic View for POLR2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POLR2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2C Gene

Regulatory Elements for POLR2C Gene

Proteins for POLR2C Gene

  • Protein details for POLR2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19387-RPB3_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB3
    Protein Accession:
    P19387
    Secondary Accessions:
    • O15161

    Protein attributes for POLR2C Gene

    Size:
    275 amino acids
    Molecular mass:
    31441 Da
    Quaternary structure:
    • Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB11/POLR2J and RPB3/POLR2C subunits interact with each other.

neXtProt entry for POLR2C Gene

Proteomics data for POLR2C Gene at MOPED

Post-translational modifications for POLR2C Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys20, Lys81, Lys175, Lys225, and Lys255

Other Protein References for POLR2C Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for POLR2C Gene

Domains for POLR2C Gene

Gene Families for POLR2C Gene

HGNC:
  • POLR :RNA polymerase subunits

UniProtKB/Swiss-Prot:

RPB3_HUMAN
Family:
  • Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.:
    • P19387
genes like me logo Genes that share domains with POLR2C: view

Function for POLR2C Gene

Molecular function for POLR2C Gene

GENATLAS Biochemistry: polymerase II,RNA (DNA directed) small polypeptide C (33kDa)
UniProtKB/Swiss-Prot Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity).

Gene Ontology (GO) - Molecular Function for POLR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001055 contributes_to RNA polymerase II activity IBA --
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed RNA polymerase activity --
GO:0005515 protein binding --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with POLR2C: view
genes like me logo Genes that share phenotypes with POLR2C: view

miRNA for POLR2C Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for POLR2C Gene

Localization for POLR2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR2C Gene COMPARTMENTS Subcellular localization image for POLR2C gene
Compartment Confidence
nucleus 5
cytoskeleton 4
chloroplast 1
cytosol 1

Gene Ontology (GO) - Cellular Components for POLR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9852112
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex IDA 9852112
GO:0005737 cytoplasm IDA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with POLR2C: view

Pathways for POLR2C Gene

SuperPathways for POLR2C Gene

Superpath Contained pathways
1 Formation of RNA Pol II elongation complex
2 DNA Repair
3 Assembly of RNA Polymerase-II Initiation Complex
4 mRNA Splicing - Major Pathway
5 HIV Life Cycle
genes like me logo Genes that share pathways with POLR2C: view

Gene Ontology (GO) - Biological Process for POLR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006289 nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated --
genes like me logo Genes that share ontologies with POLR2C: view

Transcripts for POLR2C Gene

Unigene Clusters for POLR2C Gene

Polymerase (RNA) II (DNA directed) polypeptide C, 33kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2C Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for POLR2C Gene

GeneLoc Exon Structure for
POLR2C
ECgene alternative splicing isoforms for
POLR2C

Expression for POLR2C Gene

mRNA expression in normal human tissues for POLR2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLR2C Gene

SOURCE GeneReport for Unigene cluster for POLR2C Gene Hs.79402

genes like me logo Genes that share expressions with POLR2C: view

Orthologs for POLR2C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR2C 36
  • 99.03 (n)
  • 100 (a)
POLR2C 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POLR2C 36
  • 92.24 (n)
  • 99.64 (a)
POLR2C 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR2C 36
  • 92.85 (n)
  • 99.64 (a)
POLR2C 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr2c 36
  • 91.03 (n)
  • 99.27 (a)
Polr2c 16
Polr2c 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLR2C 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLR2C 37
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polr2c 36
  • 91.76 (n)
  • 99.27 (a)
chicken
(Gallus gallus)
Aves POLR2C 36
  • 84 (n)
  • 96.36 (a)
POLR2C 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLR2C 37
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16883 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76329 36
polr2c 36
  • 79.64 (n)
  • 94.55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5536 36
zebrafish
(Danio rerio)
Actinopterygii polr2c 36
  • 78.42 (n)
  • 89.82 (a)
polr2c 37
  • 90 (a)
OneToOne
wufk48d01 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010321 36
  • 64.46 (n)
  • 70.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpII33 36
  • 68.73 (n)
  • 69.34 (a)
RpII33 37
  • 69 (a)
OneToOne
RpII33 38
  • 69 (a)
worm
(Caenorhabditis elegans)
Secernentea rpb-3 36
  • 57.74 (n)
  • 57.99 (a)
rpb-3 37
  • 55 (a)
OneToOne
C36B1.3 38
  • 56 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL120C 36
  • 55 (n)
  • 48.08 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB3 36
  • 51.92 (n)
  • 47.31 (a)
RPB3 37
  • 38 (a)
OneToOne
RPB3 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16170g 36
  • 53.05 (n)
  • 49.03 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1797 36
soybean
(Glycine max)
eudicotyledons Gma.10273 36
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPB3 36
  • 50.6 (n)
  • 49.4 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.9186 36
rice
(Oryza sativa)
Liliopsida Os.5510 36
Os09g0110400 36
  • 56.7 (n)
  • 47.51 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.10459 36
bread mold
(Neurospora crassa)
Ascomycetes NCU01515 36
  • 56.08 (n)
  • 49.6 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb3 36
  • 51.67 (n)
  • 47.79 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5647 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4193 37
  • 68 (a)
OneToOne
Species with no ortholog for POLR2C:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for POLR2C Gene

ENSEMBL:
Gene Tree for POLR2C (if available)
TreeFam:
Gene Tree for POLR2C (if available)

Paralogs for POLR2C Gene

Pseudogenes.org Pseudogenes for POLR2C Gene

genes like me logo Genes that share paralogs with POLR2C: view

No data available for Paralogs for POLR2C Gene

Variants for POLR2C Gene

Sequence variations from dbSNP and Humsavar for POLR2C Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs4937 -- 57,465,990(+) TCAGT(C/T)CTTCA synonymous-codon, reference
rs170365 -- 57,469,448(+) GATTC(C/T)TCTTG intron-variant
rs178601 -- 57,462,582(+) TCGGC(A/G)GTTCT upstream-variant-2KB
rs223837 -- 57,463,019(+) CTTTT(C/G)ATCTT intron-variant
rs223838 -- 57,464,973(+) GTCTT(C/G)AGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR2C Gene

Variant ID Type Subtype PubMed ID
nsv906724 CNV Loss 21882294
nsv833245 CNV Loss 17160897
esv2676266 CNV Deletion 23128226
nsv906725 CNV Loss 21882294

Relevant External Links for POLR2C Gene

HapMap Linkage Disequilibrium report
POLR2C

Disorders for POLR2C Gene

(1) MalaCards Diseases for POLR2C Gene

Search for POLR2C Gene in MalaCards »

Relevant External Links for POLR2C

Genetic Association Database (GAD)
POLR2C
Human Genome Epidemiology (HuGE) Navigator
POLR2C
genes like me logo Genes that share disorders with POLR2C: view

No data available for UniProtKB/Swiss-Prot for POLR2C Gene

Publications for POLR2C Gene

  1. Chromosomal localization of human RNA polymerase II subunit genes. (PMID: 8034326) Acker J. … Kedinger C. (Genomics 1994) 2 3
  2. The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin. (PMID: 12207009) Corbi N. … Passananti C. (FASEB J. 2002) 3 23
  3. RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product. (PMID: 16141233) Corbi N. … Passananti C. (J. Cell. Sci. 2005) 3 23
  4. The amino acid sequence of the human RNA polymerase II 33-kDa subunit hRPB 33 is highly conserved among eukaryotes. (PMID: 2187864) Pati U.K. … Weissman S.M. (J. Biol. Chem. 1990) 3 4
  5. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PMID: 9852112) Kershnar E. … Chiang C.-M. (J. Biol. Chem. 1998) 3 4

Products for POLR2C Gene

  • antibodies-online proteins for POLR2C
  • antibodies-online antibodies for POLR2C
  • antibodies-online kits for POLR2C

Sources for POLR2C Gene

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