Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POLR2C Gene

protein-coding   GIFtS: 65
GCID: GC16P057496

Polymerase (RNA) II (DNA Directed) Polypeptide C, 33kDa

(Previous name: polymerase (RNA) II (DNA directed) polypeptide C (33kD))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Polymerase (RNA) II (DNA Directed) Polypeptide C, 33kDa1 2     RNA Polymerase II Subunit B32 3
RNA Polymerase II Subunit 31 2 3     Polymerase (RNA) II (DNA Directed) Polypeptide C (33kD)1
RPB312 3     RPB32
RPB332 3     DNA-Directed RNA Polymerase II Subunit RPB32
DNA-Directed RNA Polymerase II 33 KDa Polypeptide2 3     hRPB332
DNA-Directed RNA Polymerase II Subunit C2 3     hsRPB32

External Ids:    HGNC: 91891   Entrez Gene: 54322   Ensembl: ENSG000001029787   OMIM: 1806635   UniProtKB: P193873   

Export aliases for POLR2C gene to outside databases

Previous GC identifers: GC16P047891 GC16P057556 GC16P057230 GC16P057271 GC16P056054 GC16P043364


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POLR2C Gene:
This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing
messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer
with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A
pseudogene has been identified on chromosome 21. (provided by RefSeq, Jul 2008)

GeneCards Summary for POLR2C Gene: 
POLR2C (polymerase (RNA) II (DNA directed) polypeptide C, 33kDa) is a protein-coding gene. Diseases associated with POLR2C include shigellosis, and conjunctivitis, and among its related super-pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and Purine metabolism. GO annotations related to this gene include DNA-directed RNA polymerase activity and protein dimerization activity.

UniProtKB/Swiss-Prot: RPB3_HUMAN, P19387
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional
non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is
composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central
large cleft and the clamp element that moves to open and close the cleft (By similarity)

Gene Wiki entry for POLR2C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POLR2C gene promoter:
         MyoD   CUTL1   CREB   MEF-2A   deltaCREB   aMEF-2   Meis-1a   Zic3   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOLR2C promoter sequence
   Search SABiosciences Chromatin IP Primers for POLR2C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLR2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13-q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q13-q21

POLR2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR2C gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P057496:  view genomic region     (about GC identifiers)

Start:
57,496,299 bp from pter      End:
57,505,922 bp from pter
Size:
9,624 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RPB3_HUMAN, P19387 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase II subunit RPB3  
Size: 275 amino acids; 31441 Da
Subunit: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB11/POLR2J and
RPB3/POLR2C subunits interact with each other
Subcellular location: Nucleus
Secondary accessions: O15161

Explore the universe of human proteins at neXtProt for POLR2C: NX_P19387

Explore proteomics data for POLR2C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P19387

  • POLR2C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    POLR2C Protein Expression
    REFSEQ proteins: NP_116558.1  
    ENSEMBL proteins: 
     ENSP00000219252   ENSP00000456367  
    Reactome Protein details: P19387
    Human Recombinant Protein Products for POLR2C: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for POLR2C
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for POLR2C
    GenScript Custom Purified and Recombinant Proteins Services for POLR2C
    Novus Biologicals POLR2C Proteins
    Novus Biologicals POLR2C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for POLR2C 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005665DNA-directed RNA polymerase II, core complex IDA9852112
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--

    POLR2C for ontologies           About GeneDecksing



    POLR2C Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of POLR2C
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for POLR2C
    GenScript Custom Superior Antibodies Services for POLR2C
    Novus Biologicals POLR2C Antibodies
    Abcam antibodies for POLR2C
    Cloud-Clone Corp. Antibodies for POLR2C 
    ThermoFisher Antibodies for POLR2C
    LSBio Antibodies in human, mouse, rat for POLR2C 

    Assay Products for POLR2C: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for POLR2C
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for POLR2C
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for POLR2C 
    Cloud-Clone Corp. CLIAs for POLR2C


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    POLR: RNA polymerase subunits

    5 InterPro protein domains:
     IPR011263 DNA-dir_RNA_pol_RpoA/D/Rpb3
     IPR011262 DNA-dir_RNA_pol_insert
     IPR011261 DNA-dir_RNA_pol_dimersation
     IPR001514 DNA-dir_RNA_pol_30-40kDasu_CS
     IPR009025 DNA-dir_RNA_pol_RBP11-like

    Graphical View of Domain Structure for InterPro Entry P19387

    ProtoNet protein and cluster: P19387

    1 Blocks protein domain: IPB001514 DNA-directed RNA polymerase

    UniProtKB/Swiss-Prot: RPB3_HUMAN, P19387
    Similarity: Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family


    POLR2C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPB3_HUMAN, P19387
    Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
    triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional
    non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is
    composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central
    large cleft and the clamp element that moves to open and close the cleft (By similarity)

         Genatlas biochemistry entry for POLR2C:
    polymerase II,RNA (DNA directed) small polypeptide C (33kDa)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001055contributes to RNA polymerase II activity IBA--
    GO:0003677DNA binding IEA--
    GO:0003899DNA-directed RNA polymerase activity ----
    GO:0005515protein binding ----
    GO:0046983protein dimerization activity IEA--
         
    POLR2C for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for POLR2C:
     Decreased viability of wild-ty  Increased S DNA content  S arrest  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for POLR2C 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POLR2C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POLR2C 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POLR2C 

    miRNA
    Products:
        
    miRTarBase miRNAs that target POLR2C:
    hsa-let-7b (MIRT001607)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLR2C
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate POLR2C:
    hsa-miR-549 hsa-miR-137 hsa-miR-192* hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidPOLR2C 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for POLR2C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLR2C

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for POLR2C
    Sirion Biotech Customized adenovirus for overexpression of POLR2C

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for POLR2C (see all 8)
    OriGene ORF clones in mouse, rat for POLR2C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POLR2C (NM_032940)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLR2C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR2C
    Sirion Biotech Customized lentivirus for stable overexpression of POLR2C 
                         Customized lentivirus expression plasmids for stable overexpression of POLR2C 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for POLR2C
    Search LifeMap BioReagents cell lines for POLR2C
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2C


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for POLR2C About   (see all 26)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Pausing and recovery of Tat-mediated HIV elongation0.73
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Tat-mediated HIV elongation arrest and recovery0.73
    mRNA Capping0.93
    RNA Polymerase II Pre-transcription Events0.72
    HIV Transcription Elongation0.78
    Abortive elongation of HIV-1 transcript in the absence of Tat0.72
    2Purine metabolism
    Purine metabolism0.38
    ATP/ITP metabolism0.31
    Pyrimidine metabolism0.38
    3mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA Splicing0.82
    mRNA Processing0.85
    mRNA Splicing - Minor Pathway0.40
    mRNA Splicing - Major Pathway0.82
    4Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Protein Acetylation and Deacetylation0.51
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    5HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for POLR2C
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    DNA damage Role of Brca1 and Brca2 in DNA repair
    ATP/ITP metabolism

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POLR2C (see all 17)
        Nuclear Receptor Activation by Vitamin-A
    Telomerase Components in Cell Signaling
    Androgen Signaling
    NF-kappaB Activation by Viruses
    Crosstalk Between CARM1 and ESRs

    3 GeneGo (Thomson Reuters) Pathways for POLR2C
        DNA damage Role of Brca1 and Brca2 in DNA repair
    ATP/ITP metabolism
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for POLR2C
        Eukaryotic Transcription Initiation

    5/44        Reactome Pathways for POLR2C (see all 44)
        Tat-mediated HIV elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    mRNA Splicing
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    Regulatory RNA pathways


    5/6         Kegg Pathways  (Kegg details for POLR2C) (see all 6):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways
    RNA polymerase
    Huntington's disease


    POLR2C for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POLR2C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/404 Interacting proteins for POLR2C (P193872, 3 ENSP000002192524) via UniProtKB, MINT, STRING, and/or I2D (see all 404)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2WQ96B022, 3, ENSP000003974534MINT-63530 I2D: score=5 STRING: ENSP00000397453
    C14orf1Q9UKR52, 3MINT-63532 I2D: score=5 
    STC2O760612, 3MINT-63527 I2D: score=5 
    LRIF1Q5T3J32, 3MINT-63531 I2D: score=4 
    DDX39BQ138383I2D: score=1 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006281DNA repair TAS--
    GO:0006283transcription-coupled nucleotide-excision repair TAS--
    GO:0006289nucleotide-excision repair TAS--
    GO:0006351transcription, DNA-dependent ----

    POLR2C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for POLR2C:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POLR2C (RPB3)

    Search CenterWatch for drugs/clinical trials and news about POLR2C / RPB3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POLR2C gene (2 alternative transcripts): 
    NM_032940.2  NM_002694.2  

    Unigene Cluster for POLR2C:

    Polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
    Hs.79402  [show with all ESTs]
    Unigene Representative Sequence: NM_032940
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000219252(uc002elt.1) ENST00000563115(uc010vhq.2) ENST00000562953
    ENST00000562599 ENST00000564651 ENST00000567982 ENST00000564626 ENST00000563589

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLR2C
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate POLR2C:
    hsa-miR-549 hsa-miR-137 hsa-miR-192* hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidPOLR2C 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for POLR2C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLR2C
    Clone
    Products:
         
    OriGene clones in human, mouse for POLR2C (see all 8)
    OriGene ORF clones in mouse, rat for POLR2C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POLR2C (NM_032940)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLR2C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR2C
    Sirion Biotech Customized lentivirus for stable overexpression of POLR2C 
                         Customized lentivirus expression plasmids for stable overexpression of POLR2C 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for POLR2C
    OriGene qSTAR qPCR primer pairs in human, mouse for POLR2C
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POLR2C
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR2C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR2C

    Additional mRNA sequence: 

    AF008443.1 AJ224144.1 AK293112.1 AK295582.1 AK300124.1 BC000409.2 BC003159.1 BC028157.1 
    CR542041.1 J05448.1 

    18 DOTS entries:

    DT.100733658  DT.454003  DT.100673226  DT.419003  DT.95168015  DT.95168017  DT.100887494  DT.100765430 
    DT.100887510  DT.120657520  DT.100887499  DT.100887511  DT.92457518  DT.95320158  DT.120657607  DT.75161520 
    DT.95078452  DT.95168020 

    24/376 AceView cDNA sequences (see all 376):

    CD107266 BE889808 CR594917 BM852687 CA941304 BQ877480 AA323628 CR626527 
    BE646255 BC003159 BE621236 AI335813 BC000409 CA488932 CA941597 BE563113 
    BX280194 BU729446 BU150156 AW410072 CA414084 BF437515 BI835644 BF984345 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for POLR2C (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:              -                                   -           -     -                     
    SP2:              -                                   -           -                           
    SP3:              -                                   -                                       
    SP4:              -                                                                           
    SP5:                                                                                          


    ECgene alternative splicing isoforms for POLR2C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POLR2C expression in normal human tissues (normalized intensities)      POLR2C embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACAAAGCAG
    POLR2C Expression
    About this image


    POLR2C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   

    See POLR2C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POLR2C

    SOURCE GeneReport for Unigene cluster: Hs.79402
        SABiosciences Custom PCR Arrays for POLR2C
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for POLR2C
    OriGene qSTAR qPCR primer pairs in human, mouse for POLR2C
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POLR2C
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR2C
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR2C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for POLR2C gene from 10/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Polr2c1 , 5 polymerase (RNA) II (DNA directed) polypeptide C1, 5 91.03(n)1
    99.27(a)1
      8 (46.92 cM)5
    200211  NM_009090.51  NP_033116.21 
     948574505 
    chicken
    (Gallus gallus)
    Aves POLR2C1 polymerase (RNA) II (DNA directed) polypeptide C, 33kDa 84(n)
    96.36(a)
      415635  XM_414001.2  XP_414001.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    POLR2C6
    Uncharacterized protein
    polymerase (RNA) II (DNA directed) polypeptide C, ...
    97(a)
    79(a)
    possible ortholog
    1 ↔ 1
    GL343675.1(192484-199473)
    GL343202.1(2889123-2889766)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.168832 Xenopus laevis transcribed sequence with strong similarity more 79.09(n)    CA972428.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk48d012 wufk48d01 78.84(n)   334669  BC046047.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpII331 , 3 transcription from Pol II promoter
    DNA-directed more3
    RNA polymerase II 33kD subunit1
    69(a)3
    68.73(n)1
    69.34(a)1
      34D63
    347961  NM_058071.31  NP_477419.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C36B1.33
    rpb-31
    DNA directed RNA polymerase II3
    Protein RPB-31
    56(a)3
    57.74(n)1
    57.99(a)1
      I(8736829-8738823)3
    1726801  NM_059960.51  NP_492361.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPB3(YIL021W)4
    RPB31
    RNA polymerase II third largest subunit B44, part of more4
    Rpb3p1
    51.92(n)1
    47.31(a)1
      9(312905-313861)4
    8547911, 4  NP_012243.31  NP_012243.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NRPB31 DNA-directed RNA polymerase II subunit RPB3-A 49.87(n)
    48.02(a)
      816035  NM_127103.2  NP_179145.1 
    rice
    (Oryza sativa)
    Liliopsida Os.55102 Oryza sativa (japonica cultivar-group) cDNA clone0 more 70.22(n)    AK120034.1 


    ENSEMBL Gene Tree for POLR2C (if available)
    TreeFam Gene Tree for POLR2C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POLR2C gene

    POLR2C for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for POLR2C
    PGOHUM00000239146


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/231 SNPs in POLR2C are shown (see all 231)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1816913251,2
    --57495740(+) ATTTAC/TCAAGA 1 -- us2k10--------
    rs1864424371,2
    --57495842(+) TGGTTA/GCTCTT 1 -- us2k10--------
    rs748736971,2
    C,F--57495863(+) TTAAAT/CGTATT 1 -- us2k11Minor allele frequency- C:0.19WA 118
    rs1396681741,2
    C--57495928(+) TTGAGG/TCCCAT 1 -- us2k10--------
    rs1179086281,2
    C,F--57495942(+) AACCTC/TTCTCC 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs283626321,2
    C,F--57495978(+) TCTTTG/ATTGAG 1 -- us2k17Minor allele frequency- A:0.05MN EA WA NA 1496
    rs1908972891,2
    --57496005(+) TGCCCA/GCTGCC 1 -- us2k10--------
    rs283626331,2
    C,F--57496094(+) AAGAAC/TATTGT 1 -- us2k1 tfbs34Minor allele frequency- T:0.05MN EA NA 1492
    rs578460861,2
    C,F--57496228(+) TTTCTA/GTAGAT 1 -- us2k12Minor allele frequency- G:0.04WA 120
    rs1152586231,2
    F--57496234(+) TAGATG/ATACAA 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for POLR2C (57496299 - 57505922 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for POLR2C:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676266CNV Deletion23128226
    nsv906724CNV Loss21882294
    nsv833245CNV Loss17160897
    nsv906725CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing POLR2C
    DNA2.0 Custom Variant and Variant Library Synthesis for POLR2C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 180663    OMIM disorders: --

    4 diseases for POLR2C:    About MalaCards
    shigellosis    conjunctivitis    huntington's disease    psoriasis


    POLR2C for disorders           About GeneDecksing

    Genetic Association Database (GAD): POLR2C
    Human Genome Epidemiology (HuGE) Navigator: POLR2C (2 documents)

    Export disorders for POLR2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POLR2C gene, integrated from 9 sources (see all 140):
    (articles sorted by number of sources associating them with POLR2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (1999)
    4. Cloning and characterization of the human RNA polymerase I subunit hRPA40. (PubMed id 9540830)1, 2 Dammann R. and Pfeifer G.P. (1998)
    5. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PubMed id 9852112)1, 2 Kershnar E.... Chiang C.-M. (1998)
    6. Chromosomal localization of human RNA polymerase II subunit genes. (PubMed id 8034326)1, 3 Acker J....Kedinger C. (1994)
    7. The amino acid sequence of the human RNA polymerase II 33-kDa subunit hRPB 33 is highly conserved among eukaryotes. (PubMed id 2187864)1, 2 Pati U.K. and Weissman S.M. (1990)
    8. RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product. (PubMed id 16141233)1, 9 Corbi N....Passananti C. (2005)
    9. The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin. (PubMed id 12207009)1, 9 Corbi N....Passananti C. (2002)
    10. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5432 HGNC: 9189 AceView: POLR2C Ensembl:ENSG00000102978 euGenes: HUgn5432
    ECgene: POLR2C Kegg: 5432 H-InvDB: POLR2C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POLR2C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for POLR2C gene:
    Search GeneIP for patents involving POLR2C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore small molecules (inhibitor) for POLR2C
     EMD Millipore Mono- and Polyclonal Antibodies for the study of POLR2C
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for POLR2C  
     OriGene qPCR primer pairs and template standards for POLR2C   OriGene Protein Over-expression Lysate for POLR2C  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for POLR2C  
     OriGene qSTAR qPCR primer pairs in human, mouse for POLR2C   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for POLR2C   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for POLR2C   OriGene Custom Protein Services for POLR2C  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POLR2C
     QIAGEN SeqTarget long-range PCR primers for resequencing POLR2C
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLR2C
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLR2C
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLR2C
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLR2C
     GenScript Custom Purified and Recombinant Proteins Services for POLR2C GenScript cDNA clones with any tag delivered in your preferred vector for POLR2C
     GenScript Custom Assay Services for POLR2C GenScript Custom Superior Antibodies Services for POLR2C
     GenScript Custom overexpressing Cell Line Services for POLR2C CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in POLR2C promoter
     Search Chromatin IP Primers for POLR2C
     RT2 qPCR Primer Assay in human, mouse, rat POLR2C
     GNC Network for POLR2C
     SABiosciences PCR Arrays including human, mouse, rat POLR2C
     Search Tocris compounds for POLR2C (RPB3)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     POLR2C antibodies
     POLR2C proteins
     POLR2C lysates
     Antibodies for POLR2C
     See all of Abcam's Antibodies, Kits and Proteins for POLR2C
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for POLR2C
     Antibodies for POLR2C
     ELISAs for POLR2C
     CLIAs for POLR2C
     Search LifeMap BioReagents cell lines for POLR2C
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2C
     SwitchGear 3'UTR luciferase reporter plasmids for POLR2C
     SwitchGear Promoter luciferase reporter plasmids for POLR2C
     ThermoFisher Antibodies for POLR2C
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLR2C
     inGenious Targeting Laboratory - Custom generated mouse model solutions for POLR2C
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POLR2C
    Customized:
     lentivirus for stable overexpression of POLR2C
     lentivirus expression plasmids for stable overexpression of POLR2C
     adenovirus for overexpression of POLR2C
     LSBio Antibodies in human, mouse, rat for POLR2C
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      POLR2C gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4