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Aliases for POLR2B Gene

Aliases for POLR2B Gene

  • RNA Polymerase II Subunit B 2 3 5
  • DNA-Directed RNA Polymerase II 140 KDa Polypeptide 3 4
  • DNA-Directed RNA Polymerase II Subunit B 3 4
  • RNA Polymerase II Subunit B2 3 4
  • RNA Polymerase II Subunit 2 3 4
  • EC 2.7.7.6 4 61
  • Polymerase (RNA) II (DNA Directed) Polypeptide B (140kD) 2
  • Polymerase (RNA) II (DNA Directed) Polypeptide B, 140kDa 3
  • DNA-Directed RNA Polymerase II Subunit RPB2 3
  • RNA Polymerase II Second Largest Subunit 3
  • Polymerase (RNA) II Subunit B 3
  • EC 2.7.7 61
  • HRPB140 3
  • POL2RB 3
  • RPB2 3

External Ids for POLR2B Gene

Previous GeneCards Identifiers for POLR2B Gene

  • GC04P057648
  • GC04P057841
  • GC04P057760
  • GC04P057685
  • GC04P057538
  • GC04P053798
  • GC04P057844

Summaries for POLR2B Gene

Entrez Gene Summary for POLR2B Gene

  • This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for POLR2B Gene

POLR2B (RNA Polymerase II Subunit B) is a Protein Coding gene. Diseases associated with POLR2B include Eumycotic Mycetoma. Among its related pathways are HIV Life Cycle and CCR5 Pathway in Macrophages. GO annotations related to this gene include poly(A) RNA binding and DNA-directed 5-3 RNA polymerase activity. An important paralog of this gene is POLR3B.

UniProtKB/Swiss-Prot for POLR2B Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).

Gene Wiki entry for POLR2B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2B Gene

Genomics for POLR2B Gene

Regulatory Elements for POLR2B Gene

Enhancers for POLR2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G057101 1.3 Ensembl ENCODE dbSUPER 9.9 +125.8 125770 4.7 FOXA2 ARID4B THRB RARA GATA2 FOS HMG20B NR2F2 KAT8 MAFF POLR2B NOA1 IGFBP7-AS1 IGFBP7 UBE2CP3
GH04G056799 1.1 Ensembl ENCODE 10.1 -177.6 -177589 1.5 ATF1 TBL1XR1 WRNIP1 ZNF48 RAD21 YY1 GATA2 ZNF143 RELB IKZF2 SPINK2 PAICS PPAT NOA1 POLR2B SRP72 REST ENSG00000269949 LOC105377668 GC04P056807
GH04G056906 1 ENCODE 11 -68.8 -68752 4.6 PKNOX1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 FOS NOA1 ENSG00000269949 POLR2B SPINK2 ENSG00000251799 RNU6-998P REST GC04P056945
GH04G057097 1.1 Ensembl ENCODE dbSUPER 9.9 +121.4 121394 2.6 PRDM6 ZKSCAN8 BCL6 NR2F6 NR2F2 RARA RNU6-998P NOA1 POLR2B IGFBP7-AS1 UBE2CP3
GH04G057093 1.1 Ensembl ENCODE dbSUPER 9.6 +117.7 117695 2.9 MAX FOS NFE2 MAFK NR2F2 NFE2L2 EGR2 RNU6-998P NOA1 POLR2B IGFBP7-AS1 UBE2CP3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLR2B on UCSC Golden Path with GeneCards custom track

Promoters for POLR2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000168712 278 4401 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for POLR2B Gene

Chromosome:
4
Start:
56,977,722 bp from pter
End:
57,031,168 bp from pter
Size:
53,447 bases
Orientation:
Plus strand

Genomic View for POLR2B Gene

Genes around POLR2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2B Gene

Proteins for POLR2B Gene

  • Protein details for POLR2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30876-RPB2_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB2
    Protein Accession:
    P30876
    Secondary Accessions:
    • A8K1A8
    • Q8IZ61

    Protein attributes for POLR2B Gene

    Size:
    1174 amino acids
    Molecular mass:
    133897 Da
    Quaternary structure:
    • Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. Interacts with WDR82. Interacts with MEN1.
    Miscellaneous:
    • The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits (By similarity).

    Three dimensional structures from OCA and Proteopedia for POLR2B Gene

neXtProt entry for POLR2B Gene

Selected DME Specific Peptides for POLR2B Gene

P30876:
  • AVGLVKNLALMAYISVGS
  • FGEMERD
  • GVSQVLNR
  • AMGKQAMG
  • HMVDDKIH
  • PQIGDKF
  • PILEFLEEW
  • EGRSRDGGLR
  • IFIGPTY
  • THCEIHP
  • GPTYYQRL
  • TDAGRICRPL
  • PSRMTIG
  • GDKFASR
  • TTRSMEYL
  • IGKIPIM
  • IPFPDHNQSPR
  • LNECPLDPGGYF
  • GKLAKPRQLHN
  • INGSEKVLIAQE
  • GGYFIING
  • PMMPNEARLRNLTY
  • KLRRQMDIIVSEVSM
  • LYYPQKPL
  • NPHAIPSRM
  • FCETKKAYF
  • KLLFQEL
  • ATKIFVNG
  • PLYVDITK
  • CPAETPEG
  • GEMERDC
  • HNQSPRNTYQ
  • GYNQEDS
  • DPEMMEMVKPSLDEAFV
  • SLDEAFV
  • ARLRNLTYSAPLYVD
  • STLSHLRR
  • LATGNWG
  • DGLIAPGVRVSG
  • KRLDLAGPLL
  • KGLVRQQLDSFD

Post-translational modifications for POLR2B Gene

  • Ubiquitination at posLast=9595, posLast=130130, posLast=134134, posLast=146146, Lys151, Lys199, Lys214, posLast=264264, posLast=340340, Lys421, Lys445, Lys457, Lys578, Lys730, Lys756, Lys821, posLast=831831, posLast=847847, posLast=869869, posLast=917917, Lys934, Lys942, posLast=988988, posLast=993993, posLast=10101010, Lys1036, Lys1143, and Lys1156
  • Modification sites at PhosphoSitePlus

Domains & Families for POLR2B Gene

Gene Families for POLR2B Gene

Suggested Antigen Peptide Sequences for POLR2B Gene

Graphical View of Domain Structure for InterPro Entry

P30876

UniProtKB/Swiss-Prot:

RPB2_HUMAN :
  • Belongs to the RNA polymerase beta chain family.
Family:
  • Belongs to the RNA polymerase beta chain family.
genes like me logo Genes that share domains with POLR2B: view

Function for POLR2B Gene

Molecular function for POLR2B Gene

GENATLAS Biochemistry:
polymerase II,RNA (DNA directed) large polypeptide B (140kDa)
UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).

Enzyme Numbers (IUBMB) for POLR2B Gene

Gene Ontology (GO) - Molecular Function for POLR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001055 contributes_to RNA polymerase II activity IBA --
GO:0003677 DNA binding IEA,TAS --
GO:0003682 chromatin binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0003899 DNA-directed 5-3 RNA polymerase activity IEA --
genes like me logo Genes that share ontologies with POLR2B: view
genes like me logo Genes that share phenotypes with POLR2B: view

Animal Model Products

CRISPR Products

miRNA for POLR2B Gene

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2B Gene

Localization for POLR2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR2B gene
Compartment Confidence
nucleus 5
cytoskeleton 2
mitochondrion 2
cytosol 2

Gene Ontology (GO) - Cellular Components for POLR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0005634 nucleus IDA,IEA 9852112
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex IDA 9852112
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with POLR2B: view

Pathways & Interactions for POLR2B Gene

SuperPathways for POLR2B Gene

SuperPathway Contained pathways
1 Formation of HIV elongation complex in the absence of HIV Tat
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 mRNA Capping
4 HIV Life Cycle
.45
5 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
genes like me logo Genes that share pathways with POLR2B: view

Gene Ontology (GO) - Biological Process for POLR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated TAS,IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with POLR2B: view

No data available for SIGNOR curated interactions for POLR2B Gene

Drugs & Compounds for POLR2B Gene

(8) Drugs for POLR2B Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0
Actinomycin D Pharma RNA polymerase inhibitor 0

(2) Additional Compounds for POLR2B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • 5-Methyl-dUTP
  • Deoxy-TTP
365-08-2

(3) ApexBio Compounds for POLR2B Gene

Compound Action Cas Number
Actinomycin D RNA polymerase inhibitor 50-76-0
PSI-6206 Inhibitor of HCV RNA polymerase,potent and selective 863329-66-2
PSI-7977 Antiviral agents for chronic HCV infection 1190307-88-0
genes like me logo Genes that share compounds with POLR2B: view

Drug Products

Transcripts for POLR2B Gene

Unigene Clusters for POLR2B Gene

Polymerase (RNA) II (DNA directed) polypeptide B, 140kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a ·
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - -
SP14: - - -
SP15:

ExUns: 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for POLR2B Gene

GeneLoc Exon Structure for
POLR2B
ECgene alternative splicing isoforms for
POLR2B

Expression for POLR2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR2B Gene

This gene is overexpressed in Lymph node (17.1) and Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POLR2B Gene



Protein tissue co-expression partners for POLR2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLR2B Gene:

POLR2B

SOURCE GeneReport for Unigene cluster for POLR2B Gene:

Hs.602757

Evidence on tissue expression from TISSUES for POLR2B Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with POLR2B: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR2B Gene

Orthologs for POLR2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2B Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia POLR2B 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 100 (a)
OneToMany
-- 35
  • 81 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia POLR2B 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia POLR2B 34 35
  • 94.92 (n)
cow
(Bos Taurus)
Mammalia POLR2B 34 35
  • 94.32 (n)
mouse
(Mus musculus)
Mammalia Polr2b 34 16 35
  • 90.35 (n)
rat
(Rattus norvegicus)
Mammalia Polr2b 34
  • 89.89 (n)
chicken
(Gallus gallus)
Aves POLR2B 34 35
  • 83.82 (n)
lizard
(Anolis carolinensis)
Reptilia POLR2B 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2b 34
  • 82.61 (n)
Str.15006 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68569 34
zebrafish
(Danio rerio)
Actinopterygii polr2b 34 35
  • 77.98 (n)
Dr.16327 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13862 34
fruit fly
(Drosophila melanogaster)
Insecta RpII140 36 34 35
  • 72.35 (n)
RpIII128 36
  • 36 (a)
RpI135 36
  • 27 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003648 34
  • 69.31 (n)
worm
(Caenorhabditis elegans)
Secernentea C26E6.4 36
  • 78 (a)
rpb-2 34 35
  • 70.2 (n)
F09F7.3 36
  • 36 (a)
F14B4.3 36
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB2 34 35 37
  • 61.81 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05577g 34
  • 61.35 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR404C 34
  • 60.06 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPB2 34
  • 64.57 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3309 34
rice
(Oryza sativa)
Liliopsida Os03g0646800 34
  • 64.35 (n)
Os.25542 34
barley
(Hordeum vulgare)
Liliopsida Hv.4411 34
wheat
(Triticum aestivum)
Liliopsida Ta.12287 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1138 35
  • 82 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb2 34
  • 62.59 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05120 34
  • 59.4 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11524 34
Species where no ortholog for POLR2B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for POLR2B Gene

ENSEMBL:
Gene Tree for POLR2B (if available)
TreeFam:
Gene Tree for POLR2B (if available)

Paralogs for POLR2B Gene

Paralogs for POLR2B Gene

(3) SIMAP similar genes for POLR2B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with POLR2B: view

Variants for POLR2B Gene

Sequence variations from dbSNP and Humsavar for POLR2B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000009816 -- 57,020,284(+) GCCTC(A/G)GCCTC intron-variant
rs10000395 -- 57,008,288(+) AGCTC(C/T)GCCTT intron-variant
rs1000148356 -- 56,978,691(+) CATTG(A/G)CGGAA upstream-variant-2KB, utr-variant-5-prime
rs10002090 -- 56,993,426(+) GAGGA(C/T)TGGCT intron-variant
rs1000212588 -- 56,980,165(+) AAACC(A/G)TCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR2B Gene

Variant ID Type Subtype PubMed ID
dgv5214n100 CNV gain 25217958

Variation tolerance for POLR2B Gene

Residual Variation Intolerance Score: 3.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2B Gene

Disorders for POLR2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for POLR2B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
eumycotic mycetoma
  • eumycetoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POLR2B

Genetic Association Database (GAD)
POLR2B
Human Genome Epidemiology (HuGE) Navigator
POLR2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2B
genes like me logo Genes that share disorders with POLR2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR2B Gene

Publications for POLR2B Gene

  1. Primary structure of the second largest subunit of human RNA polymerase II (or B). (PMID: 1518060) Acker J. … Kedinger C. (J. Mol. Biol. 1992) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PMID: 19237606) Michiels S. … Benhamou S. (Carcinogenesis 2009) 3 46 64
  4. Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. (PMID: 17998332) Lee J.H. … Skalnik D.G. (Mol. Cell. Biol. 2008) 3 4 64
  5. Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers. (PMID: 17494052) Michiels S. … Benhamou S. (Carcinogenesis 2007) 3 46 64

Products for POLR2B Gene

Sources for POLR2B Gene

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