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POLR1E Gene

protein-coding   GIFtS: 57
GCID: GC09P037486

Polymerase (RNA) I Polypeptide E, 53kDa

(Previous name: polymerase (RNA) I associated factor 1)
(Previous symbol: PRAF1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Polymerase (RNA) I Polypeptide E, 53kDa1 2     RNA Polymerase I Subunit A492 3
PRAF11 2 3     RNA Polymerase I-Associated Factor 532 3
Polymerase (RNA) I Associated Factor 11 2     RNA Polymerase I Associated Factor 531
PAF532 3     DNA-Directed RNA Polymerase I Subunit RPA492
DNA-Directed RNA Polymerase I Subunit E2 3     RNA Polymerase I-Associated Factor 13

External Ids:    HGNC: 176311   Entrez Gene: 644252   Ensembl: ENSG000001370547   UniProtKB: Q9GZS13   

Export aliases for POLR1E gene to outside databases

Previous GC identifers: GC09P037477 GC09P037437


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for POLR1E Gene:
POLR1E (polymerase (RNA) I polypeptide E, 53kDa) is a protein-coding gene. GO annotations related to this gene include DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot: RPA49_HUMAN, Q9GZS1
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to
be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I
and UBTF/UBF (By similarity)

Gene Wiki entry for POLR1E Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the POLR1E gene promoter:
         Oct-B1   oct-B2   oct-B3   MEF-2   CUTL1   MEF-2A   POU2F1   FOXJ2 (long isoform)   FOXJ2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOLR1E promoter sequence
   Search Chromatin IP Primers for POLR1E

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POLR1E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.2   Ensembl cytogenetic band:  9p13.2   HGNC cytogenetic band: 9p13.1

POLR1E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR1E gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P037486:  view genomic region     (about GC identifiers)

Start:
37,485,932 bp from pter      End:
37,503,694 bp from pter
Size:
17,763 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RPA49_HUMAN, Q9GZS1 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase I subunit RPA49  
Size: 481 amino acids; 53962 Da
Subunit: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits (By similarity).
Interacts with PAF49/CD3EAP. Also binds UBTF/UBF (By similarity)
Secondary accessions: Q5VZT3 Q8NBA9 Q96L20
Alternative splicing: 2 isoforms:  Q9GZS1-1   Q9GZS1-2   

Explore the universe of human proteins at neXtProt for POLR1E: NX_Q9GZS1

Explore proteomics data for POLR1E at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys142
  • Modification sites at PhosphoSitePlus

  • See POLR1E Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269695.1  NP_071935.1  

    ENSEMBL proteins: 
     ENSP00000367029   ENSP00000367023   ENSP00000399887  

    POLR1E Human Recombinant Protein Products:

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    antibodies-online proteins for POLR1E (4 products) 

     
    antibodies-online peptides for POLR1E

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    antibodies-online kits for POLR1E (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POLR: RNA polymerase subunits

    1 InterPro protein domain:
     IPR009668 RNA_pol-assoc_fac_A49-like

    Graphical View of Domain Structure for InterPro Entry Q9GZS1

    ProtoNet protein and cluster: Q9GZS1

    UniProtKB/Swiss-Prot: RPA49_HUMAN, Q9GZS1
    Similarity: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family


    Find genes that share domains with POLR1E           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPA49_HUMAN, Q9GZS1
    Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
    triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to
    be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I
    and UBTF/UBF (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001054contributes to RNA polymerase I activity IBA--
    GO:0003677DNA binding IEA--
    GO:0003899DNA-directed RNA polymerase activity ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with POLR1E           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Polr1e):
     mortality/aging 

    Find genes that share phenotypes with POLR1E           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for POLR1E

    miRNA
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    hsa-miR-544 hsa-miR-149 hsa-miR-548c-3p hsa-miR-664*
    SwitchGear 3'UTR luciferase reporter plasmidPOLR1E 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RPA49_HUMAN, Q9GZS1: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus ISS--
    GO:0005736DNA-directed RNA polymerase I complex IBA--
    GO:0005737cytoplasm ----
    GO:0030054cell junction ----

    Find genes that share ontologies with POLR1E           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POLR1E About    
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (KEGG)
    Purine metabolism0.38
    Pyrimidine metabolism0.38
    2Formation of RNA Pol II elongation complex
    Eukaryotic Transcription Initiation0.59
    3RNA Polymerase III Transcription Initiation
    RNA polymerase0.45
    4Metabolism
    Metabolic pathways0.38
    5TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    Find genes that share SuperPaths with POLR1E           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for POLR1E
        Assembly of RNA Polymerase-I Initiation Complex

    2 BioSystems Pathways for POLR1E
        Eukaryotic Transcription Initiation
    TNF-alpha/NF-kB Signaling Pathway


    4 Kegg Pathways  (Kegg details for POLR1E):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways
    RNA polymerase

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POLR1E
    Interactions:

        GeneGlobe Interaction Network for POLR1E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for POLR1E (Q9GZS12, 3 ENSP000003670294) via UniProtKB, MINT, STRING, and/or I2D (see all 188)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR1AO956022, 3, ENSP000002638574MINT-7264825 MINT-7264930 I2D: score=2 STRING: ENSP00000263857
    SUPT16HQ9Y5B92, 3, ENSP000002162974MINT-7264879 MINT-7264825 I2D: score=2 STRING: ENSP00000216297
    CD3EAPO154462, 3, ENSP000003109664MINT-7264825 I2D: score=2 STRING: ENSP00000310966
    POLR1BQ9H9Y62, 3, ENSP000002633314MINT-7264825 I2D: score=2 STRING: ENSP00000263331
    RRN3Q9NYV62, 3, ENSP000001987674MINT-7264930 I2D: score=1 STRING: ENSP00000198767
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006360transcription from RNA polymerase I promoter IBA--
    GO:0009303rRNA transcription ISS--

    Find genes that share ontologies with POLR1E           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for POLR1E (RPA49)

    6 HMDB Compounds for POLR1E    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Uridine triphosphate5'-UTP (see all 7)63-39-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for POLR1E gene (2 alternative transcripts): 
    NM_001282766.1  NM_022490.2  

    Unigene Cluster for POLR1E:

    Polymerase (RNA) I polypeptide E, 53kDa
    Hs.591087  [show with all ESTs]
    Unigene Representative Sequence: AK225050
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377798(uc003zzy.1 uc011lqk.1) ENST00000377792(uc003zzz.1)
    ENST00000442009(uc011lqj.1)
    miRNA
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    hsa-miR-544 hsa-miR-149 hsa-miR-548c-3p hsa-miR-664*
    SwitchGear 3'UTR luciferase reporter plasmidPOLR1E 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat POLR1E
      QuantiFast Probe-based Assays in human, mouse, rat POLR1E

    Additional mRNA sequence: 

    AK023452.1 AK024032.1 AK225050.1 AK301347.1 AK302345.1 AK303167.1 BC001337.1 BC014331.1 
    BC017766.1 CR457313.1 

    9 DOTS entries:

    DT.111178  DT.97815129  DT.100669496  DT.101954912  DT.100788284  DT.100731904  DT.100788281  DT.101980862 
    DT.70105244 

    Selected AceView cDNA sequences (see all 158):

    CR619318 CR615159 AU143190 CR612093 BM742639 CB136566 BQ433552 BE613824 
    CR592070 AK024032 BE780147 BQ430252 BM836790 AI433585 BM773117 BM765182 
    BM754578 BM754510 CR620462 CR598021 BQ433912 CR611501 BV202844 BU507792 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for POLR1E    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:              -                                                                           
    SP2:                                                                                          
    SP3:                                                                                          


    ECgene alternative splicing isoforms for POLR1E

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    POLR1E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCACGCCAC
    POLR1E Expression
    About this image


    POLR1E expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    POLR1E Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POLR1E Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591087
        Custom PCR Arrays for POLR1E
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR1E

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for POLR1E gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Polr1e1 , 5 polymerase (RNA) I polypeptide E1, 5 81.29(n)1
    77.59(a)1
      4 (23.67 cM)5
    644241  NM_022811.31  NP_073722.11 
     450185835 
    chicken
    (Gallus gallus)
    Aves POLR1E1 polymerase (RNA) I polypeptide E, 53kDa 66.91(n)
    61.17(a)
      426805  XM_424416.4  XP_424416.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.58522 Xenopus laevis transcribed sequence with weak similarity to protein refNP_071935.1 (H.sapiens) hypothetical protein FLJ13390 similar to PAF53 [Homo sapiens] less 74.45(n)    BX853465.1 
    zebrafish
    (Danio rerio)
    Actinopterygii polr1e1 polymerase (RNA) I polypeptide E 56.87(n)
    43.97(a)
      553733  NM_001020704.1  NP_001018540.1 


    ENSEMBL Gene Tree for POLR1E (if available)
    TreeFam Gene Tree for POLR1E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POLR1E (see all 543)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1448663141,2
    Cuntested137469660(+) ATTCTA/GTGAAG 2 M V mis11Minor allele frequency- G:0.00NA 4550
    rs1128862351,2
    C--37451997(+) TCATCCTTC    
       TTT
    /-
    CTTCT
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1877268691,2
    --37452111(+) GCTAAA/GTGCAA 1 -- us2k10--------
    rs795593651,2
    C,F--37452183(+) CACGCC/TTGTAA 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs109733581,2
    C,F--37452305(+) AAAAAA/TCAAAA 1 -- us2k19Minor allele frequency- T:0.30NA WA CSA EA 370
    rs1450858871,2
    --37452317(+) AAAACA/TGAGTG 1 -- us2k10--------
    rs778709391,2
    C,F--37452461(+) CAAACT/CAACAA 1 -- us2k12Minor allele frequency- C:0.04WA 120
    rs1422080801,2
    --37452473(+) AAACGC/TTGGGA 1 -- us2k10--------
    rs117882931,2
    C,F,H--37452726(+) AGAGAC/AAGGGT 1 -- us2k13Minor allele frequency- A:0.13NA 124
    rs109733591,2
    C,F--37452744(+) TGTTGC/TCCAGC 1 -- us2k14Minor allele frequency- T:0.38WA CSA 124

    HapMap Linkage Disequilibrium report for POLR1E (37485932 - 37503694 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for POLR1E:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv824923CNV Gain20364138
    nsv893059CNV Gain21882294
    esv259927OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with POLR1E           About GenesLikeMe

    Genetic Association Database (GAD): POLR1E
    Human Genome Epidemiology (HuGE) Navigator: POLR1E (1 document)

    Export disorders for POLR1E gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POLR1E gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with POLR1E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    6. RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription. (PubMed id 8641287)1, 3 Hanada K....Muramatsu M. (EMBO J. 1996)
    7. Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription. (PubMed id 15226435)1, 9 Yamamoto K....Muramatsu M. (Mol. Cell. Biol. 2004)
    8. Repression of RNA polymerase I upon stress is caused by inhibition of RNA-dependent deacetylation of PAF53 by SIRT7. (PubMed id 24207024)1 Chen S....Voit R. (Mol. Cell 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64425 HGNC: 17631 AceView: PAF53 Ensembl:ENSG00000137054 euGenes: HUgn64425
    ECgene: POLR1E Kegg: 64425 H-InvDB: POLR1E

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for POLR1E Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for POLR1E gene:
    Search GeneIP for patents involving POLR1E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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