Aliases for POLR1C Gene
External Ids for POLR1C Gene
The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Defects in this gene have been associated with Treacher Collins syndrome (TCS). [provided by RefSeq, Mar 2011]
GeneCards Summary for POLR1C Gene
POLR1C (Polymerase (RNA) I Polypeptide C, 30kDa) is a Protein Coding gene. Diseases associated with POLR1C include treacher collins syndrome 3 and polr1c-related treacher collins syndrome. Among its related pathways are Epstein-Barr virus infection and Metabolism. GO annotations related to this gene include protein dimerization activity and RNA polymerase I activity.
UniProtKB/Swiss-Prot for POLR1C Gene
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).