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Aliases for POLR1C Gene

Aliases for POLR1C Gene

  • Polymerase (RNA) I Polypeptide C, 30kDa 2 3
  • RPA39 3 4 6
  • RPA40 3 4 6
  • DNA-Directed RNA Polymerases I And III 40 KDa Polypeptide 3 4
  • DNA-Directed RNA Polymerase I Subunit C 3 4
  • RNA Polymerases I And III Subunit AC1 3 4
  • RPAC1 3 6
  • RPC40 3 4
  • RPA5 3 6
  • TCS3 3 6
  • AC40 3 4
  • DNA-Directed RNA Polymerases I And III Subunit RPAC1 3
  • POLR1E 4

External Ids for POLR1C Gene

Previous GeneCards Identifiers for POLR1C Gene

  • GC06P043481
  • GC06P043531
  • GC06P043592
  • GC06P043202

Summaries for POLR1C Gene

Entrez Gene Summary for POLR1C Gene

  • The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Defects in this gene have been associated with Treacher Collins syndrome (TCS). [provided by RefSeq, Mar 2011]

GeneCards Summary for POLR1C Gene

POLR1C (Polymerase (RNA) I Polypeptide C, 30kDa) is a Protein Coding gene. Diseases associated with POLR1C include treacher collins syndrome 3 and polr1c-related treacher collins syndrome. Among its related pathways are Epstein-Barr virus infection and Metabolism. GO annotations related to this gene include protein dimerization activity and RNA polymerase I activity.

UniProtKB/Swiss-Prot for POLR1C Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).

Gene Wiki entry for POLR1C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR1C Gene

Genomics for POLR1C Gene

Regulatory Elements for POLR1C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for POLR1C Gene

Start:
43,509,702 bp from pter
End:
43,529,585 bp from pter
Size:
19,884 bases
Orientation:
Plus strand

Genomic View for POLR1C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POLR1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR1C Gene

Proteins for POLR1C Gene

  • Protein details for POLR1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15160-RPAC1_HUMAN
    Recommended name:
    DNA-directed RNA polymerases I and III subunit RPAC1
    Protein Accession:
    O15160
    Secondary Accessions:
    • O75395
    • Q5JTE3

    Protein attributes for POLR1C Gene

    Size:
    346 amino acids
    Molecular mass:
    39250 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.

    Alternative splice isoforms for POLR1C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLR1C Gene

Proteomics data for POLR1C Gene at MOPED

Post-translational modifications for POLR1C Gene

  • Ubiquitination at Lys167 and Lys224
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR1C Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for POLR1C Gene

Domains for POLR1C Gene

Gene Families for POLR1C Gene

HGNC:
  • POLR :RNA polymerase subunits

Graphical View of Domain Structure for InterPro Entry

O15160

UniProtKB/Swiss-Prot:

RPAC1_HUMAN :
  • O15160
Family:
  • Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR1C: view

Function for POLR1C Gene

Molecular function for POLR1C Gene

UniProtKB/Swiss-Prot Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).

Gene Ontology (GO) - Molecular Function for POLR1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001054 contributes_to RNA polymerase I activity IBA --
GO:0001056 contributes_to RNA polymerase III activity IBA --
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed RNA polymerase activity TAS 9540830
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with POLR1C: view
genes like me logo Genes that share phenotypes with POLR1C: view

Animal Model Products

CRISPR Products

miRNA for POLR1C Gene

miRTarBase miRNAs that target POLR1C

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POLR1C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for POLR1C Gene

Localization for POLR1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR1C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR1C Gene COMPARTMENTS Subcellular localization image for POLR1C gene
Compartment Confidence
nucleus 4
cytosol 2
chloroplast 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for POLR1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005666 DNA-directed RNA polymerase III complex IDA 24107381
GO:0005736 DNA-directed RNA polymerase I complex TAS 9540830
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR1C: view

Pathways for POLR1C Gene

genes like me logo Genes that share pathways with POLR1C: view

Gene Ontology (GO) - Biological Process for POLR1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006360 transcription from RNA polymerase I promoter TAS --
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
GO:0006362 transcription elongation from RNA polymerase I promoter TAS --
GO:0006363 termination of RNA polymerase I transcription TAS --
genes like me logo Genes that share ontologies with POLR1C: view

Compounds for POLR1C Gene

(6) HMDB Compounds for POLR1C Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Cytidine triphosphate
  • cytidine 5'-(tetrahydrogen triphosphate)
65-47-4
Guanosine triphosphate
  • 5'-GTP
86-01-1
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(18) Novoseek inferred chemical compound relationships for POLR1C Gene

Compound -log(P) Hits PubMed IDs
rrna 78 42
alpha-amanitin 67.1 4
s-napc 64 1
actinomycin d 56.4 12
deae-sephadex a-25 53.7 1
genes like me logo Genes that share compounds with POLR1C: view

Transcripts for POLR1C Gene

Unigene Clusters for POLR1C Gene

Polymerase (RNA) I polypeptide C, 30kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POLR1C

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR1C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: -
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7:

Relevant External Links for POLR1C Gene

GeneLoc Exon Structure for
POLR1C
ECgene alternative splicing isoforms for
POLR1C

Expression for POLR1C Gene

mRNA expression in normal human tissues for POLR1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLR1C Gene

SOURCE GeneReport for Unigene cluster for POLR1C Gene Hs.743509

genes like me logo Genes that share expressions with POLR1C: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLR1C Gene

Orthologs for POLR1C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR1C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR1C 35
  • 99.52 (n)
  • 100 (a)
POLR1C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POLR1C 35
  • 88.92 (n)
  • 97.11 (a)
POLR1C 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR1C 35
  • 90.94 (n)
  • 97.4 (a)
POLR1C 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr1c 35
  • 86.42 (n)
  • 93.93 (a)
Polr1c 16
Polr1c 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLR1C 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLR1C 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polr1c 35
  • 86.71 (n)
  • 94.51 (a)
chicken
(Gallus gallus)
Aves POLR1C 35
  • 75.14 (n)
  • 82.37 (a)
POLR1C 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLR1C 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr1c 35
  • 68.58 (n)
  • 74.52 (a)
zebrafish
(Danio rerio)
Actinopterygii polr1c 35
  • 68.79 (n)
  • 71.68 (a)
polr1c 36
  • 68 (a)
OneToOne
zgc65973 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012796 35
  • 57.46 (n)
  • 53.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3756 35
  • 57.74 (n)
  • 54.84 (a)
CG3756 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea H43I07.2 35
  • 52.09 (n)
  • 50.15 (a)
rpac-40 36
  • 43 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR031C 35
  • 52.94 (n)
  • 46.54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPC40 35
  • 52.04 (n)
  • 47.02 (a)
RPC40 36
  • 45 (a)
OneToOne
RPC40 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D14861g 35
  • 52.83 (n)
  • 45.91 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPAC43 35
  • 54.72 (n)
  • 52.52 (a)
corn
(Zea mays)
Liliopsida Zm.6471 35
rice
(Oryza sativa)
Liliopsida Os.18198 35
Os03g0295400 35
  • 51.89 (n)
  • 46.48 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.4262 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02533 35
  • 54.23 (n)
  • 47.4 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpc40 35
  • 53.37 (n)
  • 51.03 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5013 35
Species with no ortholog for POLR1C:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for POLR1C Gene

ENSEMBL:
Gene Tree for POLR1C (if available)
TreeFam:
Gene Tree for POLR1C (if available)

Paralogs for POLR1C Gene

No data available for Paralogs for POLR1C Gene

Variants for POLR1C Gene

Sequence variations from dbSNP and Humsavar for POLR1C Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1127166 -- 43,521,403(+) GTTTT(C/T)TGGGA utr-variant-3-prime, intron-variant
rs9472069 -- 43,519,625(+) TCCCT(A/C)CCTCT intron-variant
rs11544826 -- 43,519,438(+) TAGCT(C/G)AGGTG missense, reference
rs55653636 -- 43,519,793(+) GGCTC(A/T)TTCCC reference, missense
rs59157986 -- 43,519,057(+) TAAGC(A/C)CTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR1C Gene

Variant ID Type Subtype PubMed ID
dgv6841n71 CNV Loss 21882294
nsv818414 CNV Gain 17921354

Relevant External Links for POLR1C Gene

HapMap Linkage Disequilibrium report
POLR1C
Human Gene Mutation Database (HGMD)
POLR1C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR1C Gene

Disorders for POLR1C Gene

(1) OMIM Diseases for POLR1C Gene (610060)

UniProtKB/Swiss-Prot

RPAC1_HUMAN
  • Treacher Collins syndrome 3 (TCS3) [MIM:248390]: A form of Treacher Collins syndrome, a disorder of craniofacial development. Treacher Collins syndrome is characterized by a combination of bilateral downward slanting of the palpebral fissures, colobomas of the lower eyelids with a paucity of eyelashes medial to the defect, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss. {ECO:0000269 PubMed:21131976}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(15) Novoseek inferred disease relationships for POLR1C Gene

Disease -log(P) Hits PubMed IDs
sclerosis systemic 46.8 4
cockayne syndrome 38.9 1
werner syndrome 34.1 1
retinoblastoma 31.6 5
mixed connective tissue disease 19.9 1
genes like me logo Genes that share disorders with POLR1C: view

Publications for POLR1C Gene

  1. Rrn3 becomes inactivated in the process of ribosomal DNA transcription. (PMID: 12646563) Hirschler-Laszkiewicz I. … Rothblum L.I. (J. Biol. Chem. 2003) 3 23
  2. Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. (PMID: 12393749) Yuan X. … Grummt I. (EMBO Rep. 2002) 3 23
  3. WRN helicase accelerates the transcription of ribosomal RNA as a component of an RNA polymerase I-associated complex. (PMID: 11971179) Shiratori M. … Matsumoto T. (Oncogene 2002) 3 23
  4. Cloning and characterization of the human RNA polymerase I subunit hRPA40. (PMID: 9540830) Dammann R. … Pfeifer G.P. (Biochim. Biophys. Acta 1998) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for POLR1C Gene

Sources for POLR1C Gene

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