Aliases for POLR1B Gene
External Ids for POLR1B Gene
Previous GeneCards Identifiers for POLR1B Gene
Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).[supplied by OMIM, Mar 2008]
GeneCards Summary for POLR1B Gene
POLR1B (Polymerase (RNA) I Polypeptide B, 128kDa) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and DNA Damage. GO annotations related to this gene include DNA-directed RNA polymerase activity and ribonucleoside binding. An important paralog of this gene is POLR2B.
UniProtKB/Swiss-Prot for POLR1B Gene
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).