Free for academic non-profit institutions. Other users need a Commercial license

Aliases for POLR1B Gene

Aliases for POLR1B Gene

  • Polymerase (RNA) I Subunit B 2 3
  • DNA-Directed RNA Polymerase I 135 KDa Polypeptide 3 4
  • Polymerase (RNA) I Polypeptide B, 128kDa 2 3
  • Polymerase (RNA) I Polypeptide B 3 5
  • RNA Polymerase I Subunit 2 3 4
  • EC 2.7.7.6 4 63
  • RPA135 3 4
  • DNA-Directed RNA Polymerase I 135kDa Polypeptide 3
  • Rpo1-2 3
  • RPA2 3

External Ids for POLR1B Gene

Previous GeneCards Identifiers for POLR1B Gene

  • GC02P111221
  • GC02P113206
  • GC02P113395
  • GC02P113015
  • GC02P113299
  • GC02P105754

Summaries for POLR1B Gene

Entrez Gene Summary for POLR1B Gene

  • Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).[supplied by OMIM, Mar 2008]

GeneCards Summary for POLR1B Gene

POLR1B (Polymerase (RNA) I Subunit B) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include DNA-directed RNA polymerase activity and ribonucleoside binding.

UniProtKB/Swiss-Prot for POLR1B Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).

Gene Wiki entry for POLR1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR1B Gene

Genomics for POLR1B Gene

Regulatory Elements for POLR1B Gene

Promoters for POLR1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POLR1B on UCSC Golden Path with GeneCards custom track

Genomic Location for POLR1B Gene

Chromosome:
2
Start:
112,541,915 bp from pter
End:
112,577,153 bp from pter
Size:
35,239 bases
Orientation:
Plus strand

Genomic View for POLR1B Gene

Genes around POLR1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR1B Gene

Proteins for POLR1B Gene

  • Protein details for POLR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9Y6-RPA2_HUMAN
    Recommended name:
    DNA-directed RNA polymerase I subunit RPA2
    Protein Accession:
    Q9H9Y6
    Secondary Accessions:
    • B7Z6Y7
    • B7Z823
    • F5GZX4
    • F8W898
    • Q2TAM4
    • Q585T5
    • Q6ZRR2
    • Q9H9D3

    Protein attributes for POLR1B Gene

    Size:
    1135 amino acids
    Molecular mass:
    128229 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.

    Alternative splice isoforms for POLR1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLR1B Gene

Proteomics data for POLR1B Gene at MOPED

Post-translational modifications for POLR1B Gene

  • Ubiquitination at Lys 17, Lys 94, and Lys 442
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for POLR1B Gene

Gene Families for POLR1B Gene

Graphical View of Domain Structure for InterPro Entry

Q9H9Y6

UniProtKB/Swiss-Prot:

RPA2_HUMAN :
  • Belongs to the RNA polymerase beta chain family.
Family:
  • Belongs to the RNA polymerase beta chain family.
genes like me logo Genes that share domains with POLR1B: view

Function for POLR1B Gene

Molecular function for POLR1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).

Enzyme Numbers (IUBMB) for POLR1B Gene

Gene Ontology (GO) - Molecular Function for POLR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001054 contributes_to RNA polymerase I activity IBA --
genes like me logo Genes that share ontologies with POLR1B: view
genes like me logo Genes that share phenotypes with POLR1B: view

Animal Model Products

miRNA for POLR1B Gene

miRTarBase miRNAs that target POLR1B

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR1B Gene

Localization for POLR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR1B Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR1B Gene COMPARTMENTS Subcellular localization image for POLR1B gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for POLR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005736 DNA-directed RNA polymerase I complex IBA --
genes like me logo Genes that share ontologies with POLR1B: view

Pathways & Interactions for POLR1B Gene

SuperPathways for POLR1B Gene

Superpath Contained pathways
1 Telomere C-strand (Lagging Strand) Synthesis
2 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
3 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
4 DNA Double-Strand Break Repair
5 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
genes like me logo Genes that share pathways with POLR1B: view

Gene Ontology (GO) - Biological Process for POLR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
GO:0006362 transcription elongation from RNA polymerase I promoter TAS --
GO:0006363 termination of RNA polymerase I transcription TAS --
GO:0009303 rRNA transcription IEA --
genes like me logo Genes that share ontologies with POLR1B: view

No data available for SIGNOR curated interactions for POLR1B Gene

Drugs & Compounds for POLR1B Gene

(6) Drugs for POLR1B Gene - From: HMDB and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0

(2) Additional Compounds for POLR1B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • 5-Methyl-dUTP
  • Deoxy-TTP
365-08-2
genes like me logo Genes that share compounds with POLR1B: view

Transcripts for POLR1B Gene

Unigene Clusters for POLR1B Gene

Polymerase (RNA) I polypeptide B, 128kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLR1B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: -
SP5:
SP6: -
SP7:
SP8: - - - -

ExUns: 19b ^ 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for POLR1B Gene

GeneLoc Exon Structure for
POLR1B
ECgene alternative splicing isoforms for
POLR1B

Expression for POLR1B Gene

mRNA expression in normal human tissues for POLR1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR1B Gene

This gene is overexpressed in Liver, secretome (11.4), Lymph node (11.0), and Peripheral blood mononuclear cells (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POLR1B Gene



SOURCE GeneReport for Unigene cluster for POLR1B Gene Hs.745127

genes like me logo Genes that share expression patterns with POLR1B: view

Protein tissue co-expression partners for POLR1B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLR1B Gene

Orthologs for POLR1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR1B 36
  • 100 (a)
OneToOne
POLR1B 35
  • 99.47 (n)
  • 99.56 (a)
cow
(Bos Taurus)
Mammalia POLR1B 36
  • 94 (a)
OneToOne
POLR1B 35
  • 88.93 (n)
  • 93.74 (a)
dog
(Canis familiaris)
Mammalia POLR1B 35
  • 90.81 (n)
  • 93.83 (a)
POLR1B 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr1b 16
Polr1b 35
  • 84.96 (n)
  • 90.31 (a)
Polr1b 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLR1B 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLR1B 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polr1b 35
  • 85.47 (n)
  • 90.67 (a)
chicken
(Gallus gallus)
Aves POLR1B 35
  • 71.44 (n)
  • 73.95 (a)
POLR1B 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLR1B 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68946 35
tropical clawed frog
(Silurana tropicalis)
Amphibia polr1b 35
  • 72.13 (n)
  • 77.43 (a)
Str.17855 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6132 35
zebrafish
(Danio rerio)
Actinopterygii polr1b 35
  • 69.44 (n)
  • 75.89 (a)
polr1b 36
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009539 35
  • 51.25 (n)
  • 46.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpI135 36
  • 44 (a)
OneToOne
RpI135 35
  • 52.24 (n)
  • 46.48 (a)
worm
(Caenorhabditis elegans)
Secernentea rpoa-2 36
  • 43 (a)
OneToOne
F14B4.3 35
  • 52.82 (n)
  • 46.66 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR029W 35
  • 52.48 (n)
  • 47.04 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPA135 35
  • 52.06 (n)
  • 46.57 (a)
RPB2 36
  • 25 (a)
OneToMany
RPA135 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B06303g 35
  • 52.63 (n)
  • 46.67 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPA2 35
  • 51.07 (n)
  • 44.61 (a)
rice
(Oryza sativa)
Liliopsida Os.46652 35
wheat
(Triticum aestivum)
Liliopsida Ta.4946 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08616 35
  • 52.58 (n)
  • 48.95 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpa2 35
  • 53.91 (n)
  • 50.78 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8215 35
Species with no ortholog for POLR1B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for POLR1B Gene

ENSEMBL:
Gene Tree for POLR1B (if available)
TreeFam:
Gene Tree for POLR1B (if available)

Paralogs for POLR1B Gene

genes like me logo Genes that share paralogs with POLR1B: view

No data available for Paralogs for POLR1B Gene

Variants for POLR1B Gene

Sequence variations from dbSNP and Humsavar for POLR1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1545133 - 112,551,896(+) TTGTT(C/T)GACAC reference, missense
rs3789724 -- 112,556,217(-) TGAGT(A/G)GAAGA intron-variant
rs3816140 -- 112,551,045(+) ATTCA(C/T)TGGGG intron-variant
rs3816141 -- 112,564,769(+) TAACT(G/T)TTTTC intron-variant
rs3961914 -- 112,560,404(-) CTCCT(A/G)CAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR1B Gene

Variant ID Type Subtype PubMed ID
nsv874877 CNV Loss 21882294
nsv458997 CNV Gain 19166990

Variation tolerance for POLR1B Gene

Residual Variation Intolerance Score: 10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.26; 92.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR1B Gene

HapMap Linkage Disequilibrium report
POLR1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR1B Gene

Disorders for POLR1B Gene

Relevant External Links for POLR1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR1B

No disorders were found for POLR1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR1B Gene

Publications for POLR1B Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 67
  2. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for POLR1B Gene

Sources for POLR1B Gene

Back to Top

Content