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Aliases for POLR1B Gene

Aliases for POLR1B Gene

  • RNA Polymerase I Subunit B 2 3 5
  • DNA-Directed RNA Polymerase I 135 KDa Polypeptide 3 4
  • Polymerase (RNA) I Polypeptide B, 128kDa 2 3
  • RNA Polymerase I Subunit 2 3 4
  • EC 2.7.7.6 4 61
  • RPA135 3 4
  • DNA-Directed RNA Polymerase I 135kDa Polypeptide 3
  • DNA-Directed RNA Polymerase I Subunit RPA2 3
  • Polymerase (RNA) I Subunit B 3
  • Rpo1-2 3
  • RPA2 3

External Ids for POLR1B Gene

Previous GeneCards Identifiers for POLR1B Gene

  • GC02P111221
  • GC02P113206
  • GC02P113395
  • GC02P113015
  • GC02P113299
  • GC02P105754
  • GC02P112567
  • GC02P112674
  • GC02P112822

Summaries for POLR1B Gene

Entrez Gene Summary for POLR1B Gene

  • Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).[supplied by OMIM, Mar 2008]

GeneCards Summary for POLR1B Gene

POLR1B (RNA Polymerase I Subunit B) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Escape and Assembly of RNA Polymerase-I Initiation Complex. GO annotations related to this gene include DNA-directed 5-3 RNA polymerase activity and ribonucleoside binding.

UniProtKB/Swiss-Prot for POLR1B Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).

Gene Wiki entry for POLR1B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR1B Gene

Genomics for POLR1B Gene

Regulatory Elements for POLR1B Gene

Enhancers for POLR1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G112541 1.1 ENCODE 52 +0.7 665 2.9 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 ZFP64 WRNIP1 ARID4B SIN3A POLR1B CHCHD5 RGPD8 ENSG00000207383 ENSG00000243389 ZC3H8 LOC105373562 PIR56853
GH02G112582 1.4 FANTOM5 ENCODE 35.2 +42.3 42303 3.3 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YBX1 YY1 SLC30A9 POLR1B CHCHD5 TMEM87B RPS20P11 RGPD8 ZC3H6 GC02M112581
GH02G112621 2 FANTOM5 Ensembl ENCODE dbSUPER 18.6 +85.4 85430 11.8 HDGF PKNOX1 FOXA2 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 FLJ42351 POLR1B CHCHD5 NT5DC4 ENSG00000243389 ENSG00000207383 IL37 IL1B ANAPC1 IL1A
GH02G112053 2 FANTOM5 Ensembl ENCODE dbSUPER 15.2 -485.9 -485939 5.3 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 MERTK TMEM87B POLR1B RGPD8 CKAP2L ZC3H6 GC02M112043
GH02G112583 0.7 ENCODE 35.4 +40.5 40534 0.2 CTCF PKNOX1 ZNF654 TRIM22 ZNF384 REST DPF2 RAD21 FOXK2 ZNF143 POLR1B ENSG00000207383 GC02M112580 CHCHD5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLR1B on UCSC Golden Path with GeneCards custom track

Promoters for POLR1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000121947 685 2401 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 ZFP64 WRNIP1 ARID4B SIN3A

Genomic Location for POLR1B Gene

Chromosome:
2
Start:
112,541,915 bp from pter
End:
112,577,153 bp from pter
Size:
35,239 bases
Orientation:
Plus strand

Genomic View for POLR1B Gene

Genes around POLR1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR1B Gene

Proteins for POLR1B Gene

  • Protein details for POLR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9Y6-RPA2_HUMAN
    Recommended name:
    DNA-directed RNA polymerase I subunit RPA2
    Protein Accession:
    Q9H9Y6
    Secondary Accessions:
    • B7Z6Y7
    • B7Z823
    • F5GZX4
    • F8W898
    • Q2TAM4
    • Q585T5
    • Q6ZRR2
    • Q9H9D3

    Protein attributes for POLR1B Gene

    Size:
    1135 amino acids
    Molecular mass:
    128229 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.

    Alternative splice isoforms for POLR1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLR1B Gene

Selected DME Specific Peptides for POLR1B Gene

Q9H9Y6:
  • FGEMERD
  • DNPDSLVNQEVL
  • YQRLRHMV
  • PSRMTIG
  • GDKFASR
  • NPHGFPSRMT
  • GGYFIING
  • YGTERLYSG
  • CPVHTPDG
  • EKVIRMLI
  • VAVISYTGYD
  • VPKGTICK
  • DSGLCVVADKLNF
  • RYLSHFRCVHRGA
  • QMGKQTMG
  • TGYDMEDAMI
  • NQSPRNMYQCQM

Post-translational modifications for POLR1B Gene

  • Ubiquitination at posLast=1717, posLast=9494, and posLast=442442
  • Modification sites at PhosphoSitePlus

Domains & Families for POLR1B Gene

Gene Families for POLR1B Gene

Graphical View of Domain Structure for InterPro Entry

Q9H9Y6

UniProtKB/Swiss-Prot:

RPA2_HUMAN :
  • Belongs to the RNA polymerase beta chain family.
Family:
  • Belongs to the RNA polymerase beta chain family.
genes like me logo Genes that share domains with POLR1B: view

Function for POLR1B Gene

Molecular function for POLR1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).

Enzyme Numbers (IUBMB) for POLR1B Gene

Gene Ontology (GO) - Molecular Function for POLR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001054 contributes_to RNA polymerase I activity IBA --
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed 5-3 RNA polymerase activity IEA --
GO:0005515 protein binding IPI 16514417
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with POLR1B: view
genes like me logo Genes that share phenotypes with POLR1B: view

Animal Model Products

CRISPR Products

miRNA for POLR1B Gene

miRTarBase miRNAs that target POLR1B

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR1B Gene

Localization for POLR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR1B Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR1B gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for POLR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005736 DNA-directed RNA polymerase I complex IBA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with POLR1B: view

Pathways & Interactions for POLR1B Gene

genes like me logo Genes that share pathways with POLR1B: view

Gene Ontology (GO) - Biological Process for POLR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
GO:0006362 transcription elongation from RNA polymerase I promoter TAS --
GO:0006363 termination of RNA polymerase I transcription TAS --
GO:0007566 embryo implantation IEA --
genes like me logo Genes that share ontologies with POLR1B: view

No data available for SIGNOR curated interactions for POLR1B Gene

Drugs & Compounds for POLR1B Gene

(6) Drugs for POLR1B Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0

(2) Additional Compounds for POLR1B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • 5-Methyl-dUTP
  • Deoxy-TTP
365-08-2

(1) ApexBio Compounds for POLR1B Gene

Compound Action Cas Number
BMH-21 RNA polymerase I Inhibitior 896705-16-1
genes like me logo Genes that share compounds with POLR1B: view

Drug Products

Transcripts for POLR1B Gene

Unigene Clusters for POLR1B Gene

Polymerase (RNA) I polypeptide B, 128kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR1B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: -
SP5:
SP6: -
SP7:
SP8: - - - -

ExUns: 19b ^ 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for POLR1B Gene

GeneLoc Exon Structure for
POLR1B
ECgene alternative splicing isoforms for
POLR1B

Expression for POLR1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR1B Gene

This gene is overexpressed in Liver, secretome (11.4), Lymph node (11.0), and Peripheral blood mononuclear cells (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POLR1B Gene



Protein tissue co-expression partners for POLR1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLR1B Gene:

POLR1B

SOURCE GeneReport for Unigene cluster for POLR1B Gene:

Hs.745127

Evidence on tissue expression from TISSUES for POLR1B Gene

  • Spleen(4.2)
  • Pancreas(4.1)
  • Nervous system(3)
genes like me logo Genes that share expression patterns with POLR1B: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR1B Gene

Orthologs for POLR1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR1B 34 35
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia POLR1B 34 35
  • 90.81 (n)
cow
(Bos Taurus)
Mammalia POLR1B 34 35
  • 88.93 (n)
oppossum
(Monodelphis domestica)
Mammalia POLR1B 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLR1B 35
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polr1b 34
  • 85.47 (n)
mouse
(Mus musculus)
Mammalia Polr1b 34 16 35
  • 84.96 (n)
chicken
(Gallus gallus)
Aves POLR1B 34 35
  • 71.44 (n)
lizard
(Anolis carolinensis)
Reptilia POLR1B 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr1b 34
  • 72.13 (n)
Str.17855 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68946 34
zebrafish
(Danio rerio)
Actinopterygii polr1b 34 35
  • 69.44 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6132 34
fruit fly
(Drosophila melanogaster)
Insecta RpI135 34 35
  • 52.24 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009539 34
  • 51.25 (n)
worm
(Caenorhabditis elegans)
Secernentea F14B4.3 34
  • 52.82 (n)
rpoa-2 35
  • 43 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B06303g 34
  • 52.63 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR029W 34
  • 52.48 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPA135 34 37
  • 52.06 (n)
RPB2 35
  • 25 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPA2 34
  • 51.07 (n)
rice
(Oryza sativa)
Liliopsida Os.46652 34
wheat
(Triticum aestivum)
Liliopsida Ta.4946 34
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpa2 34
  • 53.91 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08616 34
  • 52.58 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8215 34
Species where no ortholog for POLR1B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for POLR1B Gene

ENSEMBL:
Gene Tree for POLR1B (if available)
TreeFam:
Gene Tree for POLR1B (if available)

Paralogs for POLR1B Gene

genes like me logo Genes that share paralogs with POLR1B: view

No data available for Paralogs for POLR1B Gene

Variants for POLR1B Gene

Sequence variations from dbSNP and Humsavar for POLR1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000037345 -- 112,562,883(+) ATCAT(A/G)CCCGG intron-variant
rs1000045991 -- 112,566,765(+) TCTCG(A/C/T)TCTGT intron-variant
rs1000197293 -- 112,566,567(+) TAATT(G/T)TGTGA intron-variant
rs1000321390 -- 112,560,129(+) GAAAA(A/G/T)AAAAA intron-variant
rs1000395770 -- 112,566,204(+) ATGAC(A/G)TTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR1B Gene

Variant ID Type Subtype PubMed ID
esv3592009 CNV loss 21293372
nsv458997 CNV gain 19166990
nsv582708 CNV gain 21841781

Variation tolerance for POLR1B Gene

Residual Variation Intolerance Score: 10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.26; 92.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR1B Gene

Disorders for POLR1B Gene

Relevant External Links for POLR1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR1B

No disorders were found for POLR1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR1B Gene

Publications for POLR1B Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. hRRN3 is essential in the SL1-mediated recruitment of RNA polymerase I to rRNA gene promoters. (PMID: 11250903) Miller G. … Zomerdijk J.C.B.M. (EMBO J. 2001) 3 4 64
  4. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for POLR1B Gene

Sources for POLR1B Gene

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