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Aliases for POLR1A Gene

Aliases for POLR1A Gene

  • RNA Polymerase I Subunit A 2 3 5
  • DNA-Directed RNA Polymerase I Largest Subunit 3 4
  • Polymerase (RNA) I Polypeptide A, 194kDa 2 3
  • DNA-Directed RNA Polymerase I Subunit A 3 4
  • RNA Polymerase I 194 KDa Subunit 3 4
  • EC 2.7.7.6 4 61
  • RPA194 3 4
  • A190 3 4
  • DNA-Directed RNA Polymerase I Subunit RPA1 3
  • DNA-Directed RNA Polymerase I Subunit A1 3
  • Polymerase (RNA) I Subunit A 3
  • RNA Polymerase I Subunit A1 4
  • AFDCIN 3
  • RPO1-4 3
  • RPO14 3
  • RPA1 3

External Ids for POLR1A Gene

Previous GeneCards Identifiers for POLR1A Gene

  • GC02M086547
  • GC02M086211
  • GC02M086228
  • GC02M086227
  • GC02M086165
  • GC02M086253
  • GC02M086249

Summaries for POLR1A Gene

Entrez Gene Summary for POLR1A Gene

  • The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis. [provided by RefSeq, May 2016]

GeneCards Summary for POLR1A Gene

POLR1A (RNA Polymerase I Subunit A) is a Protein Coding gene. Diseases associated with POLR1A include Acrofacial Dysostosis, Cincinnati Type and Acrofacial Dysostosis. Among its related pathways are GPCR Pathway and RNA Polymerase I Promoter Escape. GO annotations related to this gene include DNA-directed 5-3 RNA polymerase activity and RNA polymerase I activity.

UniProtKB/Swiss-Prot for POLR1A Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).

Gene Wiki entry for POLR1A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR1A Gene

Genomics for POLR1A Gene

Regulatory Elements for POLR1A Gene

Enhancers for POLR1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G086104 1.1 ENCODE 36.8 -0.2 -164 3.2 HDGF PKNOX1 MLX CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 YY1 POLR1A SNORD94 MRPL35 PTCD3 PIR61452
GH02G086032 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.3 +68.5 68511 9.5 HDGF TBP PKNOX1 FOXA2 ZSCAN4 NFXL1 GLI4 RAD21 YY1 ZNF207 POLR1A IMMT LOC284950 ATOH8 RNU1-38P MRPL35 KDM3A ELMOD3 GNLY PLGLB1
GH02G086079 1.6 FANTOM5 Ensembl ENCODE dbSUPER 22.8 +25.9 25921 2.9 WRNIP1 SIN3A ZNF2 RAD21 ZNF143 RELB DEK EGR2 ZNF654 CEBPB IMMT POLR1A LOC284950 ATOH8 RNU1-38P MRPL35 GNLY KDM3A GC02M086068 GC02P086094
GH02G086222 1.7 FANTOM5 Ensembl ENCODE dbSUPER 20.8 -118.3 -118288 4.0 HDGF CTCF MXI1 ZIC2 RAD21 ZFHX2 POLR2A EED SCRT2 CREM MRPL35 IMMT POLR1A REEP1 ENSG00000251974 ENSG00000202537 ENSG00000273080 RNF103 RMND5A GC02M086172
GH02G086071 1.3 FANTOM5 Ensembl ENCODE 24.6 +33.6 33553 1.7 CTCF MAX ZNF384 EBF1 RAD21 YY1 FOSL1 HNF4G SMC3 NFE2 POLR1A IMMT GC02M086068 GC02P086094
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLR1A on UCSC Golden Path with GeneCards custom track

Promoters for POLR1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119711 55 2601 HDGF PKNOX1 MLX CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 YY1

Genomic Location for POLR1A Gene

Chromosome:
2
Start:
86,020,216 bp from pter
End:
86,106,155 bp from pter
Size:
85,940 bases
Orientation:
Minus strand

Genomic View for POLR1A Gene

Genes around POLR1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR1A Gene

Proteins for POLR1A Gene

  • Protein details for POLR1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95602-RPA1_HUMAN
    Recommended name:
    DNA-directed RNA polymerase I subunit RPA1
    Protein Accession:
    O95602
    Secondary Accessions:
    • B7Z7T0
    • D6W5M0
    • Q0VG05
    • Q9UEH0
    • Q9UFT9

    Protein attributes for POLR1A Gene

    Size:
    1720 amino acids
    Molecular mass:
    194811 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits (PubMed:16809778). Interacts with MYO1C (By similarity). Interacts with ERBB2 (PubMed:21555369). Interacts with DDX11 (PubMed:26089203).
    SequenceCaution:
    • Sequence=AAC99959.1; Type=Frameshift; Positions=1114, 1469; Evidence={ECO:0000305}; Sequence=AAD09356.1; Type=Frameshift; Positions=1114; Evidence={ECO:0000305};

neXtProt entry for POLR1A Gene

Selected DME Specific Peptides for POLR1A Gene

O95602:
  • VFATKLTYP
  • VYGIAVDPRHLSL
  • MAGREGL
  • AQSIGEP
  • DTAVKTSRSGYLQRC
  • TQMTLNTFH
  • GPNVHPGA
  • DFDGDEMN
  • YGEDGLD
  • GREGLVD
  • TVRDSDGS
  • VNTMQISCLLGQIELEG
  • NADFDGD
  • PTLHRPSIQA

Post-translational modifications for POLR1A Gene

  • Ubiquitination at Lys5, Lys31, posLast=413413, Lys573, Lys933, Lys960, Lys981, Lys1199, and posLast=17041704
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR1A Gene

Domains & Families for POLR1A Gene

Gene Families for POLR1A Gene

Graphical View of Domain Structure for InterPro Entry

O95602

UniProtKB/Swiss-Prot:

RPA1_HUMAN :
  • Belongs to the RNA polymerase beta chain family.
Family:
  • Belongs to the RNA polymerase beta chain family.
genes like me logo Genes that share domains with POLR1A: view

Function for POLR1A Gene

Molecular function for POLR1A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).

Enzyme Numbers (IUBMB) for POLR1A Gene

Gene Ontology (GO) - Molecular Function for POLR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001054 RNA polymerase I activity IMP 23782956
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IDA 26089203
GO:0003899 DNA-directed 5-3 RNA polymerase activity IEA --
GO:0005515 protein binding IPI 16514417
genes like me logo Genes that share ontologies with POLR1A: view
genes like me logo Genes that share phenotypes with POLR1A: view

Human Phenotype Ontology for POLR1A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for POLR1A Gene

Localization for POLR1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR1A Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR1A gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for POLR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0005736 DNA-directed RNA polymerase I complex IEA,IBA --
genes like me logo Genes that share ontologies with POLR1A: view

Pathways & Interactions for POLR1A Gene

genes like me logo Genes that share pathways with POLR1A: view

Gene Ontology (GO) - Biological Process for POLR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
GO:0006362 transcription elongation from RNA polymerase I promoter TAS --
GO:0006363 termination of RNA polymerase I transcription TAS --
GO:0045815 positive regulation of gene expression, epigenetic TAS --
genes like me logo Genes that share ontologies with POLR1A: view

No data available for SIGNOR curated interactions for POLR1A Gene

Drugs & Compounds for POLR1A Gene

(8) Drugs for POLR1A Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0

(2) Additional Compounds for POLR1A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • 5-Methyl-dUTP
  • Deoxy-TTP
365-08-2

(3) ApexBio Compounds for POLR1A Gene

Compound Action Cas Number
BMH-21 RNA polymerase I Inhibitior 896705-16-1
CX-5461 Pol I-mediated rRNA synthesis inhibitor 1138549-36-6
Foscarnet Sodium 63585-09-1
genes like me logo Genes that share compounds with POLR1A: view

Drug Products

Transcripts for POLR1A Gene

Unigene Clusters for POLR1A Gene

Polymerase (RNA) I polypeptide A, 194kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR1A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - -
SP2:
SP3:
SP4: - - - - -
SP5: - - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37 ^ 38
SP1:
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:

Relevant External Links for POLR1A Gene

GeneLoc Exon Structure for
POLR1A
ECgene alternative splicing isoforms for
POLR1A

Expression for POLR1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR1A Gene

Protein differential expression in normal tissues from HIPED for POLR1A Gene

This gene is overexpressed in Pancreas (15.5), Lymph node (14.4), and Breast (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POLR1A Gene



Protein tissue co-expression partners for POLR1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLR1A Gene:

POLR1A

SOURCE GeneReport for Unigene cluster for POLR1A Gene:

Hs.531818

Evidence on tissue expression from TISSUES for POLR1A Gene

  • Intestine(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR1A Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • respiratory
  • skeleton
Organs:
Head and neck:
  • brain
  • chin
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • nose
  • outer ear
  • pharynx
  • skull
Thorax:
  • heart
Pelvis:
  • pelvis
Limb:
  • femur
  • lower limb
  • thigh
General:
  • blood
  • blood vessel
  • skin
genes like me logo Genes that share expression patterns with POLR1A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLR1A Gene

Orthologs for POLR1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR1A 34 35
  • 99.09 (n)
dog
(Canis familiaris)
Mammalia POLR1A 34 35
  • 88.41 (n)
cow
(Bos Taurus)
Mammalia POLR1A 34 35
  • 87.16 (n)
rat
(Rattus norvegicus)
Mammalia Polr1a 34
  • 85.57 (n)
mouse
(Mus musculus)
Mammalia Polr1a 34 16 35
  • 85.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 78 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia POLR1A 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves POLR1A 34 35
  • 69.56 (n)
lizard
(Anolis carolinensis)
Reptilia POLR1A 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr1a 34
  • 68.5 (n)
Str.5369 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398274 34
zebrafish
(Danio rerio)
Actinopterygii polr1a 34 35
  • 65.13 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12794 34
fruit fly
(Drosophila melanogaster)
Insecta RpI1 34 35
  • 52.14 (n)
worm
(Caenorhabditis elegans)
Secernentea Y48E1A.1 34
  • 49.91 (n)
rpoa-1 35
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR374C 34
  • 48.75 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F23243g 34
  • 47.49 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPA190 34 35 37
  • 46.7 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPA1 34
  • 47.82 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01638 34
  • 49.76 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nuc1 34
  • 48.98 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2789 35
  • 47 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8935 34
Species where no ortholog for POLR1A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR1A Gene

ENSEMBL:
Gene Tree for POLR1A (if available)
TreeFam:
Gene Tree for POLR1A (if available)

Paralogs for POLR1A Gene

No data available for Paralogs for POLR1A Gene

Variants for POLR1A Gene

Sequence variations from dbSNP and Humsavar for POLR1A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs794729674 Pathogenic, Acrofacial dysostosis, Cincinnati type (AFDCIN) [MIM:616462] 86,070,107(-) GAGAC(C/G)AGATG reference, missense
VAR_073965 Acrofacial dysostosis, Cincinnati type (AFDCIN) [MIM:616462]
rs875989814 Pathogenic 86,040,483(-) CTGCC(-/C)AGAGC reference, frameshift-variant
rs1000007219 -- 86,037,613(+) CAGCT(A/C)CCAGA intron-variant
rs1000043245 -- 86,085,113(+) TCCAC(C/G)ACCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR1A Gene

Variant ID Type Subtype PubMed ID
dgv3885n100 CNV gain 25217958
dgv6946n54 CNV gain 21841781
dgv712e214 CNV gain 21293372
esv2751903 CNV gain 17911159
esv32617 CNV loss 17666407
esv3591537 CNV loss 21293372
esv3591538 CNV gain 21293372
esv3591540 CNV gain 21293372
nsv458563 CNV gain 19166990
nsv522891 CNV loss 19592680

Variation tolerance for POLR1A Gene

Residual Variation Intolerance Score: 0.681% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.61; 82.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR1A Gene

Human Gene Mutation Database (HGMD)
POLR1A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR1A Gene

Disorders for POLR1A Gene

MalaCards: The human disease database

(6) MalaCards diseases for POLR1A Gene - From: OMIM, ClinVar, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
acrofacial dysostosis, cincinnati type
  • acrofacial dysostosis cincinnati type
acrofacial dysostosis
warsaw breakage syndrome
  • wabs
dysostosis
  • dysostoses
kidney hypertrophy
  • hypertrophy of kidney
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

RPA1_HUMAN
  • Acrofacial dysostosis, Cincinnati type (AFDCIN) [MIM:616462]: A form of acrofacial dysostosis, a group of disorders which are characterized by malformation of the craniofacial skeleton and, in some patients, the limbs. {ECO:0000269 PubMed:25913037}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for POLR1A

Genetic Association Database (GAD)
POLR1A
Human Genome Epidemiology (HuGE) Navigator
POLR1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR1A
genes like me logo Genes that share disorders with POLR1A: view

No data available for Genatlas for POLR1A Gene

Publications for POLR1A Gene

  1. Molecular cloning and characterization of the cDNA encoding the largest subunit of mouse RNA polymerase I. (PMID: 9236775) Seither P. … Grummt I. (Mol. Gen. Genet. 1997) 2 3 22 64
  2. Acrofacial Dysostosis, Cincinnati Type, a Mandibulofacial Dysostosis Syndrome with Limb Anomalies, Is Caused by POLR1A Dysfunction. (PMID: 25913037) Weaver K.N. … Saal H.M. (Am. J. Hum. Genet. 2015) 3 4 64
  3. The Warsaw breakage syndrome-related protein DDX11 is required for ribosomal RNA synthesis and embryonic development. (PMID: 26089203) Sun X. … Ma L. (Hum. Mol. Genet. 2015) 3 4 64
  4. Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. (PMID: 21555369) Li L.Y. … Hung M.C. (Cancer Res. 2011) 3 4 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for POLR1A Gene

Sources for POLR1A Gene

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