Aliases for POLR1A Gene
External Ids for POLR1A Gene
Previous GeneCards Identifiers for POLR1A Gene
GeneCards Summary for POLR1A Gene
POLR1A (Polymerase (RNA) I Subunit A) is a Protein Coding gene. Diseases associated with POLR1A include Acrofacial Dysostosis, Cincinnati Type and Acrofacial Dysostosis. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include DNA-directed RNA polymerase activity and RNA polymerase I activity.
UniProtKB/Swiss-Prot for POLR1A Gene
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).