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POLN Gene

protein-coding   GIFtS: 50
GCID: GC04M002073

Polymerase (DNA Directed) Nu

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Polymerase (DNA Directed) Nu1 2
POL4P2
DNA Polymerase N2
DNA Polymerase Nu2
DNA Polymerase POL4P2
EC 2.7.7.73

External Ids:    HGNC: 188701   Entrez Gene: 3534972   Ensembl: ENSG000001309977   OMIM: 6108875   UniProtKB: Q7Z5Q53   

Export aliases for POLN gene to outside databases

Previous GC identifers: GC04U900224 GC04M002035 GC04M002040


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for POLN Gene:
POLN (polymerase (DNA directed) nu) is a protein-coding gene. GO annotations related to this gene include DNA-directed DNA polymerase activity. An important paralog of this gene is HELQ.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_006051.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the POLN gene promoter:
         Bach1   FOXO3   Nkx5-1   FOXO3b   AREB6   POU2F1   POU2F1a   FOXO3a   TGIF   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for POLN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POLN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

POLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLN gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M002073:  view genomic region     (about GC identifiers)

Start:
2,073,645 bp from pter      End:
2,243,848 bp from pter
Size:
170,204 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DPOLN_HUMAN, Q7Z5Q5 (See protein sequence)
Recommended Name: DNA polymerase nu  
Size: 900 amino acids; 100307 Da
Sequence caution: Sequence=BAD18421.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: A2A336 Q4TTW4 Q6ZNF4

Explore the universe of human proteins at neXtProt for POLN: NX_Q7Z5Q5

Explore proteomics data for POLN at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POLN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_861524.2  
    ENSEMBL proteins: 
     ENSP00000435506   ENSP00000426401   ENSP00000372316  

    POLN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for POLN
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    Novus Biologicals POLN Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for POLN 

    POLN Antibody Products:

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    Search for Antibodies for POLN at Abcam
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    LSBio Antibodies in human, mouse, rat for POLN

    POLN Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for POLN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POL: DNA polymerases

    2 InterPro protein domains:
     IPR001098 DNA-dir_DNA_pol_A_palm_dom
     IPR002298 DNA_polymerase_A

    Graphical View of Domain Structure for InterPro Entry Q7Z5Q5

    ProtoNet protein and cluster: Q7Z5Q5

    1 Blocks protein domain: IPB001098 DNA-directed DNA polymerase

    UniProtKB/Swiss-Prot: DPOLN_HUMAN, Q7Z5Q5
    Similarity: Belongs to the DNA polymerase type-A family


    Find genes that share domains with POLN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPOLN_HUMAN, Q7Z5Q5
    Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

         Enzyme Number (IUBMB): EC 2.7.7.71

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003887DNA-directed DNA polymerase activity IDA12794064
    GO:0005515protein binding IPI19995904
    GO:0030332cyclin binding IPI19995904
         
    Find genes that share ontologies with POLN           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for POLN:
     Decreased viability of wild-ty 

         1 MGI phenotypic allele for Poln (no phenotypes)

    Find genes that share phenotypes with POLN           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POLN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for POLN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POLN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POLN

    miRNA
    Products:
        
    miRTarBase miRNAs that target POLN:
    hsa-mir-335-5p (MIRT017653)

    Block miRNA regulation of human, mouse, rat POLN using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate POLN:
    hsa-miR-4261 hsa-miR-661 hsa-miR-508-5p hsa-miR-3116 hsa-miR-744* hsa-miR-4277
    SwitchGear 3'UTR luciferase reporter plasmidPOLN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for POLN
    Predesigned siRNA for gene silencing in human, mouse, rat POLN

    Gene Editing
    Products:
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POLN (NM_181808)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLN

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for POLN 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPOLN_HUMAN, Q7Z5Q5: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12794064
    GO:0005730NOT nucleolus IDA12794064

    Find genes that share ontologies with POLN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POLN About    
    See pathways by source

    SuperPathContained pathways About
    1Fanconi anemia pathway (KEGG)
    Fanconi anemia pathway


    Find genes that share SuperPaths with POLN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for POLN):
        Fanconi anemia pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POLN
    Interactions:

        Search GeneGlobe Interaction Network for POLN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for POLN (Q7Z5Q53 ENSP000003723164) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FANCAO153603, ENSP000003739524I2D: score=1 STRING: ENSP00000373952
    FANCGO152873, ENSP000003679104I2D: score=1 STRING: ENSP00000367910
    PCNAP120043, ENSP000003684384I2D: score=1 STRING: ENSP00000368438
    RAD51Q066093, ENSP000002678684I2D: score=1 STRING: ENSP00000267868
    FANCD2Q9BXW93, ENSP000002876474I2D: score=1 STRING: ENSP00000287647
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination IMP19995904
    GO:0006260DNA replication ----
    GO:0006261DNA-dependent DNA replication IDA12794064
    GO:0006281DNA repair ----
    GO:0019985translesion synthesis IMP19908865

    Find genes that share ontologies with POLN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POLN (DPOLN)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for POLN gene: 
    NM_181808.2  

    Unigene Cluster for POLN:

    Polymerase (DNA directed) nu
    Hs.368454  [show with all ESTs]
    Unigene Representative Sequence: AK131239
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000511885(uc003ger.2) ENST00000503371 ENST00000511098 ENST00000514521
    ENST00000511777 ENST00000509623 ENST00000514858(uc010ich.1) ENST00000508568
    ENST00000503601 ENST00000515357(uc011bvi.1) ENST00000510344 ENST00000506518
    ENST00000382865(uc010icg.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat POLN using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate POLN:
    hsa-miR-4261 hsa-miR-661 hsa-miR-508-5p hsa-miR-3116 hsa-miR-744* hsa-miR-4277
    SwitchGear 3'UTR luciferase reporter plasmidPOLN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for POLN
    Predesigned siRNA for gene silencing in human, mouse, rat POLN
    Clone
    Products:
         
    OriGene clones in human, mouse for POLN (see all 7)
    OriGene ORF clones in mouse, rat for POLN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POLN (NM_181808)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLN
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for POLN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POLN
      QuantiTect SYBR Green Assays in human, mouse, rat POLN
      QuantiFast Probe-based Assays in human, mouse, rat POLN

    Additional mRNA sequence: 

    AF044578.1 AK131239.1 AK303673.1 AL122048.1 AY136549.1 

    8 DOTS entries:

    DT.100675141  DT.91714320  DT.91707338  DT.92414447  DT.121236923  DT.437045  DT.65284201  DT.121236963 

    Selected AceView cDNA sequences (see all 71):

    CA865481 AI627212 CR749640 BX400052 AY136549 AW169985 AK056134 AW513701 
    BG678161 BQ024208 AA442824 AI628516 AF040964 AL709166 CA421871 BM843545 
    AV646359 BC003648 NM_181808 BC025356 AI674093 NM_024511 AA630380 BX114515 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    POLN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGCACTGAG
    POLN Expression
    About this image

    POLN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POLN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368454

    UniProtKB/Swiss-Prot: DPOLN_HUMAN, Q7Z5Q5
    Tissue specificity: Highly expressed in testis and heart. Weakly expressed in skeletal muscle

        Custom PCR Arrays for POLN
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for POLN gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Poln5 DNA polymerase N   --   5 (17.83 cM) 34007198 
    chicken
    (Gallus gallus)
    Aves POLN6
    polymerase (DNA directed) nu
    49(a)
    1 ↔ 1
    4(82459166-82544586)
    zebrafish
    (Danio rerio)
    Actinopterygii poln1 polymerase (DNA directed) nu 55.96(n)
    48.57(a)
      566857  NM_001100026.1  NP_001093496.1 
    worm
    (Caenorhabditis elegans)
    Secernentea helq-16
    Protein HELQ-1, isoform a
    6(a)
    many ↔ many
    III(577694-587105) WBGene00021905
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BRR26
    RNA-dependent ATPase RNA helicase (DEIH box); requ...
    4(a)
    1 → many
    V(529530-536021) YER172C


    ENSEMBL Gene Tree for POLN (if available)
    TreeFam Gene Tree for POLN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for POLN gene
    HELQ2  SNRNP2002  ASCC32  POLQ2  

    Find genes that share paralogs with POLN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POLN (see all 3119)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1939209761,2
    Cuntested12083401(-) ACTCCA/GGGCAC 2 Q R mis10--------
    rs1845740241,2
    --2073282(+) TCAGTC/TGGGAA 1 -- ds50010--------
    rs864901,2
    C,F,A,H--2073297(-) CCCCTG/AGAGCT 1 -- ds500130Minor allele frequency- A:0.24MN NS EA NA WA CSA 2899
    rs1874495871,2
    --2073316(+) CCTGCA/GGGGAG 1 -- ds50010--------
    rs1918794011,2
    --2073409(+) AAAGCG/TAAGGG 1 -- ds50010--------
    rs1840063461,2
    --2073441(+) TAGGGC/TGTCAG 1 -- ds50010--------
    rs1900000151,2
    --2073473(+) CTGCCA/GGGGGG 1 -- ds50010--------
    rs1489002261,2
    C,F--2073751(+) TAATGC/TGTCCT 1 -- ut311Minor allele frequency- T:0.01EU 537
    rs1812577291,2
    --2073860(+) AAGGCA/GAAAAA 2 S L mis10--------
    rs1389048871,2
    C--2073882(+) GGGCTG/AGGTGC 2 /Q /* stg11Minor allele frequency- A:0.00NA 4148

    HapMap Linkage Disequilibrium report for POLN (2073645 - 2243848 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for POLN (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726835CNV Deletion23290073
    esv1032770CNV Insertion17803354
    nsv4198CNV Insertion18451855
    esv2583887CNV Insertion19546169
    nsv291967CNV Loss16902084
    dgv5420n71CNV Loss21882294
    nsv526094CNV Loss19592680
    nsv829838CNV Loss17160897
    nsv878423CNV Loss21882294
    nsv822441CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POLN
    DNA2.0 Custom Variant and Variant Library Synthesis for POLN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610887    OMIM disorders: --


    Find genes that share disorders with POLN           About GenesLikeMe

    Genetic Association Database (GAD): POLN
    Human Genome Epidemiology (HuGE) Navigator: POLN (2 documents)

    Export disorders for POLN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POLN gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with POLN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308. (PubMed id 12794064)1, 2, 3, 9 Marini F.... Wood R.D. (J. Biol. Chem. 2003)
    2. A comprehensive genetic association study of Alzheimer disease in African Americans. (PubMed id 22159054)1, 4 Logue M.W....Farrer L.A. (Arch. Neurol. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Evidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-links. (PubMed id 19908865)1, 9 Zietlow L....Bessho T. (Biochemistry 2009)
    6. c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates PolI^ recruitment to stalled replication forks. (PubMed id 22456510)1 Barkley L.R....Vaziri C. (Mol. Biol. Cell 2012)
    7. Enhancement of human DNA polymerase I^ activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome protein. (PubMed id 23045531)1 Maddukuri L....Eoff R.L. (J. Biol. Chem. 2012)
    8. Epstein-Barr virus BPLF1 deubiquitinates PCNA and attenuates polymerase I^ recruitment to DNA damage sites. (PubMed id 22623772)1 Whitehurst C.B....Pagano J.S. (J. Virol. 2012)
    9. Genetic variants in DNA repair genes and the risk of cutaneous malignant melanoma in melanoma-prone families with/without CDKN2A mutations. (PubMed id 21671477)1 Liang X.S....Yang X.R. (Int. J. Cancer 2012)
    10. Preparation of site-specific T=mCG cis-syn cyclobutane dimer-containing template and its error-free bypass by yeast and human polymerase I^. (PubMed id 22262850)1 Song Q....Taylor J.S. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    Free Text  

      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 353497 HGNC: 18870 AceView: C4orf15andPOLN Ensembl:ENSG00000130997 euGenes: HUgn353497
    ECgene: POLN Kegg: 353497 H-InvDB: POLN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for POLN Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/poln/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for POLN gene:
    Search GeneIP for patents involving POLN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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