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POLM Gene

protein-coding   GIFtS: 62
GCID: GC07M044111

Polymerase (DNA Directed), Mu

  See POLM-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Polymerase (DNA Directed), Mu1 2     DNA Polymerase Mu2
Pol Iota1 2     DNA-Directed DNA/RNA Polymerase Mu2
Terminal Transferase2 3     Polymerase (DNA-Directed), Mu2
Pol Mu2 3     EC 2.7.7.73
Tdt-N2     polmu3

External Ids:    HGNC: 91851   Entrez Gene: 274342   Ensembl: ENSG000001226787   OMIM: 6063445   UniProtKB: Q9NP873   

Export aliases for POLM gene to outside databases

Previous GC identifers: GC07M043758 GC07M043818 GC07M043852 GC07M043886 GC07M044078 GC07M043997


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for POLM Gene:
POLM (polymerase (DNA directed), mu) is a protein-coding gene. Diseases associated with POLM include lung adenoma, and burkitt's lymphoma. GO annotations related to this gene include DNA-directed DNA polymerase activity. An important paralog of this gene is POLB.

UniProtKB/Swiss-Prot: DPOLM_HUMAN, Q9NP87
Function: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining
(NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination

Gene Wiki entry for POLM (DNA polymerase mu) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the POLM gene promoter:
         SRF   USF1   Sp1   SRF (504 AA)   NF-kappaB   AREB6   PPAR-gamma1   FAC1   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): POLM promoter sequence
   Search Chromatin IP Primers for POLM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POLM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p13

POLM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLM gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M044111:  view genomic region     (about GC identifiers)

Start:
44,111,846 bp from pter      End:
44,122,139 bp from pter
Size:
10,294 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 44,151,339-44,161,618     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DPOLM_HUMAN, Q9NP87 (See protein sequence)
Recommended Name: DNA-directed DNA/RNA polymerase mu  
Size: 494 amino acids; 54816 Da
Cofactor: Magnesium (By similarity)
Miscellaneous: DPOLM has a reduced ability to distinguish dNTP and rNTP as substrates, and elongates them on DNA
primer strand with a similar efficiency. It is able to polymerize nucleotides on RNA primer strands
2 PDB 3D structures from and Proteopedia for POLM:
2DUN (3D)        2HTF (3D)    
Secondary accessions: D3DVK4

Explore the universe of human proteins at neXtProt for POLM: NX_Q9NP87

Explore proteomics data for POLM at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys187
  • Modification sites at PhosphoSitePlus

  • See POLM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001271259.1  NP_001271260.1  NP_037416.1  

    ENSEMBL proteins: 
     ENSP00000335141   ENSP00000242248   ENSP00000388230   ENSP00000379174   ENSP00000414025  
     ENSP00000396571   ENSP00000395043   ENSP00000406750   ENSP00000397135   ENSP00000390899  
     ENSP00000399244  

    POLM Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for POLM
    OriGene Custom MassSpec
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    Novus Biologicals POLM Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for POLM 

    POLM Antibody Products:

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    Abcam antibodies for POLM
    Browse Antibodies at Cloud-Clone Corp.
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    POLM Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for POLM 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POL: DNA polymerases

    Selected InterPro protein domains (see all 10):
     IPR027249 DNA/RNApol_mu
     IPR010996 DNA_pol_b-like_N
     IPR028207 DNA_pol_B_palm_palm
     IPR001726 TdT/Mu
     IPR018944 DNA_pol_lambd_fingers_domain

    Graphical View of Domain Structure for InterPro Entry Q9NP87

    ProtoNet protein and cluster: Q9NP87

    3 Blocks protein domains:
    IPB001357 BRCT domain
    IPB001726 DNA nucleotidylexotransferase (TDT) signature
    IPB002054 DNA polymerase family X


    UniProtKB/Swiss-Prot: DPOLM_HUMAN, Q9NP87
    Similarity: Belongs to the DNA polymerase type-X family
    Similarity: Contains 1 BRCT domain


    Find genes that share domains with POLM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPOLM_HUMAN, Q9NP87
    Function: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining
    (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination
    Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

         Genatlas biochemistry entry for POLM:
    polymerase (DNA-directed), mu

         Enzyme Number (IUBMB): EC 2.7.7.71

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003824catalytic activity ----
    GO:0003887DNA-directed DNA polymerase activity IEA--
    GO:0016779nucleotidyltransferase activity ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with POLM           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for POLM:
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Polm):
     hematopoietic system  immune system  reproductive system 

    Find genes that share phenotypes with POLM           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for POLM: Polmtm1Abnd Polmtm1Crey

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POLM
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POLM
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POLM

    miRNA
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    miRTarBase miRNAs that target POLM:
    hsa-mir-335-5p (MIRT018681)

    Block miRNA regulation of human, mouse, rat POLM using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate POLM:
    hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidPOLM 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for POLM
    Predesigned siRNA for gene silencing in human, mouse, rat POLM

    Gene Editing
    Products:
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    GenScript: all cDNA clones in your preferred vector: POLM (NM_013284)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLM

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    Browse ESI BIO Cell Lines and PureStem Progenitors for POLM 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPOLM_HUMAN, Q9NP87: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    mitochondrion2
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with POLM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POLM About    
    See pathways by source

    SuperPathContained pathways About
    1Non-homologous end-joining
    Non-homologous end-joining0.37
    DNA damage NHEJ mechanisms of DSBs repair0.37


    Find genes that share SuperPaths with POLM           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for POLM
        DNA damage NHEJ mechanisms of DSBs repair


    1 Kegg Pathway  (Kegg details for POLM):
        Non-homologous end-joining

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POLM
    Interactions:

        GeneGlobe Interaction Network for POLM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for POLM (Q9NP873 ENSP000002422484) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCNAP120043, ENSP000003684384I2D: score=1 STRING: ENSP00000368438
    UBE2D2P628373, ENSP000003817174I2D: score=1 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=1 STRING: ENSP00000349722
    UBE2CO007623, ENSP000003488384I2D: score=1 STRING: ENSP00000348838
    UBE2D1P516683, ENSP000003630194I2D: score=1 STRING: ENSP00000363019
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0016446somatic hypermutation of immunoglobulin genes IEA--
    GO:0030183B cell differentiation IEA--

    Find genes that share ontologies with POLM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POLM (DPOLM)

    7 HMDB Compounds for POLM    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Thymidine 5'-triphosphate2'-Deoxythymidine 5'-triphosphate (see all 13)365-08-2--
    dATP2'-Deoxy-5'-ATP (see all 8)1927-31-7--
    dCTP2'-deoxycytidine-5'-triphosphate (see all 4)2056-98-6--
    dGTP2'-Deoxyguanosine 5'-triphosphate (see all 4)2564-35-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for POLM gene (3 alternative transcripts): 
    NM_001284330.1  NM_001284331.1  NM_013284.3  

    Unigene Cluster for POLM:

    Polymerase (DNA directed), mu
    Hs.596982  [show with all ESTs]
    Unigene Representative Sequence: BC026306
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335195 ENST00000242248(uc003tjt.3 uc003tju.3 uc003tjv.3)
    ENST00000435068 ENST00000395831 ENST00000458246(uc003tjx.2 uc011kbt.1)
    ENST00000430942 ENST00000467607 ENST00000434229 ENST00000492971 ENST00000492605(uc003tjz.4)
    ENST00000418926 ENST00000492312(uc011kbu.1 uc010kxy.2) ENST00000492321
    ENST00000497300 ENST00000445616 ENST00000414235 ENST00000452049 ENST00000483644

    miRNA
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    Block miRNA regulation of human, mouse, rat POLM using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate POLM:
    hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidPOLM 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat POLM
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    GenScript: all cDNA clones in your preferred vector: POLM (NM_013284)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLM
    Primer
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    OriGene qPCR primer pairs and template standards for POLM
    OriGene qSTAR qPCR primer pairs in human, mouse for POLM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POLM
      QuantiTect SYBR Green Assays in human, mouse, rat POLM
      QuantiFast Probe-based Assays in human, mouse, rat POLM

    Additional mRNA sequence: 

    AF176097.1 AJ131891.2 AJ844643.1 AK023002.1 AK092801.1 AK092903.1 AK291638.1 AK294449.1 
    AK307634.1 BC026306.1 BC035685.1 BC049202.1 BC062590.1 

    17 DOTS entries:

    DT.100790802  DT.211809  DT.100720427  DT.95373549  DT.65286846  DT.100790797  DT.40238589  DT.95373552 
    DT.95373557  DT.100790801  DT.91704040  DT.100746940  DT.121122737  DT.97844644  DT.121122740  DT.100698705 
    DT.121122754 

    Selected AceView cDNA sequences (see all 159):

    AF176097 AI738949 AW137352 AW207742 CA487434 AA126044 BX384388 AA046663 
    AK092903 AI057140 BE503442 AA605050 AL523598 BG231904 AK092801 BM747399 
    AA694217 BC062590 AI419960 AA917987 AA815032 AX747799 AA832314 BM756478 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for POLM (see all 18)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^
    SP1:                    -                                         -     -     -                             -                             -     -               
    SP2:                    -                                               -     -                             -                             -                     
    SP3:                    -                                               -     -                             -     -                       -     -     -     -   
    SP4:                    -                                                                                   -                                                   
    SP5:                    -                                         -     -     -     -     -     -     -     -                             -     -     -     -   

    ExUns: 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d · 16e · 16f · 16g
    SP1:  -                 -                                       
    SP2:  -                 -                                       
    SP3:  -                 -                                       
    SP4:                                                            
    SP5:  -                                                         


    ECgene alternative splicing isoforms for POLM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    POLM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTAAAAAA
    POLM Expression
    About this image

    POLM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POLM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.596982

    UniProtKB/Swiss-Prot: DPOLM_HUMAN, Q9NP87
    Tissue specificity: Expressed in a number of tissues. Abundant in thymus

        Custom PCR Arrays for POLM
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for POLM gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Polm1 , 5 polymerase (DNA directed), mu1, 5 79.38(n)1
    77.08(a)1
      11 (3.87 cM)5
    541251  NM_017401.21  NP_059097.21 
     58278605 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    56(a)
    51(a)
    1 ↔ many
    1 ↔ many
    AAWZ02038928(2885-9347)
    GL343545.1(464762-472588)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia polm1 polymerase (DNA directed), mu 55.92(n)
    50(a)
      548389  NM_001171516.1  NP_001164987.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc561222 similar to polymerase (DNA directed), mu 72.38(n)   393218  BC047832.1 


    ENSEMBL Gene Tree for POLM (if available)
    TreeFam Gene Tree for POLM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for POLM gene
    POLB2  DNTT2  POLL2  
    1 SIMAP similar gene for POLM using alignment to 11 protein entries:     DPOLM_HUMAN (see all proteins):
    DNTT

    Find genes that share paralogs with POLM           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POLM (see all 346)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1877331481,2
    --44111426(+) GGTTTC/TGCCAT 1 -- int10--------
    rs1926938501,2
    --44111476(+) CCACCA/CGTCTC 1 -- int10--------
    rs1458213521,2
    --44111525(+) GCATCC/TGGCCA 1 -- int10--------
    rs1489964421,2
    --44111726(+) GATGTA/GGCACC 1 -- int10--------
    rs1842621991,2
    --44111732(+) GCACCA/GCTAAG 1 -- int10--------
    rs1892213541,2
    --44111806(+) CCTGGC/TGTGCC 1 -- int10--------
    rs558411611,2
    C,F--44111902(+) TCCTCG/ACCTAA 1 -- ut311Minor allele frequency- A:0.03EA 120
    rs1928504961,2
    --44111957(+) TCCAGA/GTAGAT 1 -- ut310--------
    rs1123836851,2
    F--44112212(+) TCTGCG/AACGGG 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs283826641,2
    C,F--44112214(-) CTCCCG/ATCGCA 1 -- ut31 ese311Minor allele frequency- A:0.13NS NA WA CSA 288

    HapMap Linkage Disequilibrium report for POLM (44111846 - 44122139 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for POLM:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv887996CNV Loss21882294
    nsv470210CNV Loss18288195
    nsv830983CNV Loss17160897
    nsv830980CNV Loss17160897
    nsv428165CNV Gain18775914
    nsv8082CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POLM
    DNA2.0 Custom Variant and Variant Library Synthesis for POLM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606344    OMIM disorders: --

    2 diseases for POLM:    
    About MalaCards
    lung adenoma    burkitt's lymphoma

    2 diseases from the University of Copenhagen DISEASES database for POLM:
    Xeroderma pigmentosum     Lung adenoma

    Find genes that share disorders with POLM           About GenesLikeMe

    1 Novoseek inferred disease relationship for POLM gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    burkitt lymphoma 39.4 1 15520469 (1)

    Genetic Association Database (GAD): POLM
    Human Genome Epidemiology (HuGE) Navigator: POLM (1 document)

    Export disorders for POLM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POLM gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with POLM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two novel human and mouse DNA polymerases of the polX family. (PubMed id 10982892)1, 2, 3 Aoufouchi S.... Reynaud C.-A. (Nucleic Acids Res. 2000)
    2. Polymerase mu is a DNA-directed DNA/RNA polymerase. (PubMed id 12640116)1, 2, 9 Nick McElhinny S.A. and Ramsden D.A. (Mol. Cell. Biol. 2003)
    3. DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells. (PubMed id 10747040)1, 2, 9 Dominguez O.... Blanco L. (EMBO J. 2000)
    4. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (Carcinogenesis 2009)
    5. Limited terminal transferase in human DNA polymerase mu defines the required balance between accuracy and efficiency in NHEJ. (PubMed id 19805281)1, 9 Andrade P....Blanco L. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    6. Involvement of DNA polymerase mu in the repair of a specific subset of DNA double-strand breaks in mammalian cells. (PubMed id 17483519)2, 9 Capp J.P.... Canitrot Y. (Nucleic Acids Res. 2007)
    7. A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis. (PubMed id 16963491)1, 9 JuA!rez R....Blanco L. (Nucleic Acids Res. 2006)
    8. Overexpression of human DNA polymerase mu (Pol mu) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate. (PubMed id 15520469)1, 9 Ruiz J.F....Blanco L. (Nucleic Acids Res. 2004)
    9. Lesion bypass by human DNA polymerase mu reveals a template-dependent, sequence-independent nucleotidyl transferase activity. (PubMed id 14581466)1, 9 Covo S....Livneh Z. (J. Biol. Chem. 2004)
    10. Pre-steady-state kinetic studies of the fidelity of human DNA polymerase mu. (PubMed id 15504045)1, 9 Roettger M.P....Suo Z. (Biochemistry 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27434 HGNC: 9185 AceView: POLM Ensembl:ENSG00000122678 euGenes: HUgn27434
    ECgene: POLM Kegg: 27434 H-InvDB: POLM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for POLM Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/polm/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for POLM gene:
    Search GeneIP for patents involving POLM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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