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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POLM Gene

protein-coding   GIFtS: 61
GCID: GC07M044111

Polymerase (DNA Directed), Mu

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Polymerase (DNA Directed), Mu1 2     DNA Polymerase Mu2
Pol Iota1 2     DNA-Directed DNA/RNA Polymerase Mu2
Terminal Transferase2 3     Polymerase (DNA-Directed), Mu2
Pol Mu2 3     EC 2.7.7.73
Tdt-N2     polmu3

External Ids:    HGNC: 91851   Entrez Gene: 274342   Ensembl: ENSG000001226787   OMIM: 6063445   UniProtKB: Q9NP873   

Export aliases for POLM gene to outside databases

Previous GC identifers: GC07M043758 GC07M043818 GC07M043852 GC07M043886 GC07M044078 GC07M043997


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for POLM Gene: 
POLM (polymerase (DNA directed), mu) is a protein-coding gene. Diseases associated with POLM include lung adenoma, and burkitt's lymphoma, and among its related super-pathways are Non-homologous end joining. GO annotations related to this gene include DNA nucleotidylexotransferase activity and DNA-directed DNA polymerase activity. An important paralog of this gene is POLB.

UniProtKB/Swiss-Prot: DPOLM_HUMAN, Q9NP87
Function: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining
(NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination

Gene Wiki entry for POLM (DNA polymerase mu) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POLM gene promoter:
         SRF   USF1   Sp1   SRF (504 AA)   NF-kappaB   AREB6   PPAR-gamma1   FAC1   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): POLM promoter sequence
   Search SABiosciences Chromatin IP Primers for POLM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p13

POLM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLM gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M044111:  view genomic region     (about GC identifiers)

Start:
44,111,846 bp from pter      End:
44,122,139 bp from pter
Size:
10,294 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 44,151,339-44,161,618     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DPOLM_HUMAN, Q9NP87 (See protein sequence)
Recommended Name: DNA-directed DNA/RNA polymerase mu  
Size: 494 amino acids; 54816 Da
Cofactor: Magnesium (By similarity)
Subcellular location: Nucleus (By similarity)
Miscellaneous: DPOLM has a reduced ability to distinguish dNTP and rNTP as substrates, and elongates them on DNA
primer strand with a similar efficiency. It is able to polymerize nucleotides on RNA primer strands
2 PDB 3D structures from and Proteopedia for POLM:
2DUN (3D)        2HTF (3D)    
Secondary accessions: D3DVK4

Explore the universe of human proteins at neXtProt for POLM: NX_Q9NP87

Explore proteomics data for POLM at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NP87

  • POLM Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    POLM Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001271259.1  NP_001271260.1  NP_037416.1  

    ENSEMBL proteins: 
     ENSP00000335141   ENSP00000242248   ENSP00000388230   ENSP00000379174   ENSP00000414025  
     ENSP00000396571   ENSP00000395043   ENSP00000406750   ENSP00000397135   ENSP00000390899  
     ENSP00000399244  

    Human Recombinant Protein Products for POLM: 
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    OriGene Protein Over-expression Lysate for POLM
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    Novus Biologicals POLM Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    POLM for ontologies           About GeneDecksing



    POLM Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for POLM 

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    POL: DNA polymerases

    5/9 InterPro protein domains (see all 9):
     IPR027249 DNA/RNApol_mu
     IPR010996 DNA_pol_b-like_N
     IPR001726 TdT/Mu
     IPR018944 DNA_pol_lambd_fingers_domain
     IPR027421 DNA_pol_X_lyase_dom

    Graphical View of Domain Structure for InterPro Entry Q9NP87

    ProtoNet protein and cluster: Q9NP87

    3 Blocks protein domains:
    IPB001357 BRCT domain
    IPB001726 DNA nucleotidylexotransferase (TDT) signature
    IPB002054 DNA polymerase family X


    UniProtKB/Swiss-Prot: DPOLM_HUMAN, Q9NP87
    Similarity: Belongs to the DNA polymerase type-X family
    Similarity: Contains 1 BRCT domain


    POLM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPOLM_HUMAN, Q9NP87
    Function: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining
    (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination
    Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

         Genatlas biochemistry entry for POLM:
    polymerase (DNA-directed), mu

         Enzyme Number (IUBMB): EC 2.7.7.71

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003824catalytic activity ----
    GO:0003887DNA-directed DNA polymerase activity IEA--
    GO:0016779nucleotidyltransferase activity ----
    GO:0046872metal ion binding IEA--
         
    POLM for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for POLM:
     Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Polm):
     cellular  hematopoietic system  immune system  reproductive system 

    POLM for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for POLM: Polmtm1Abnd Polmtm1Crey

       inGenious Targeting Laboratory - Custom generated mouse model solutions for POLM 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POLM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POLM 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POLM 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate POLM:
    hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidPOLM 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of POLM

    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLM
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                         Customized lentivirus expression plasmids for stable overexpression of POLM 

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    Search LifeMap BioReagents cell lines for POLM
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLM


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for POLM About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Non-homologous end-joining
    Non-homologous end-joining0.46
    DNA damage NHEJ mechanisms of DSBs repair0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for POLM
        DNA damage NHEJ mechanisms of DSBs repair


    1 GeneGo (Thomson Reuters) Pathway for POLM
        DNA damage NHEJ mechanisms of DSBs repair


    1         Kegg Pathway  (Kegg details for POLM):
        Non-homologous end-joining


    POLM for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POLM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/17 Interacting proteins for POLM (Q9NP873 ENSP000002422484) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCNAP120043, ENSP000003684384I2D: score=1 STRING: ENSP00000368438
    UBE2D2P628373, ENSP000003817174I2D: score=1 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=1 STRING: ENSP00000349722
    UBE2CO007623, ENSP000003488384I2D: score=1 STRING: ENSP00000348838
    UBE2D1P516683, ENSP000003630194I2D: score=1 STRING: ENSP00000363019
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0016446somatic hypermutation of immunoglobulin genes IEA--
    GO:0030183B cell differentiation IEA--

    POLM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POLM (DPOLM)

    7 HMDB Compounds for POLM    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Thymidine 5'-triphosphate2'-Deoxythymidine 5'-triphosphate (see all 13)365-08-2--
    dATP2'-Deoxy-5'-ATP (see all 8)1927-31-7--
    dCTP2'-deoxycytidine-5'-triphosphate (see all 4)2056-98-6--
    dGTP2'-Deoxyguanosine 5'-triphosphate (see all 4)2564-35-4--

    Search CenterWatch for drugs/clinical trials and news about POLM / DPOLM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POLM gene (3 alternative transcripts): 
    NM_001284330.1  NM_001284331.1  NM_013284.3  

    Unigene Cluster for POLM:

    Polymerase (DNA directed), mu
    Hs.596982  [show with all ESTs]
    Unigene Representative Sequence: BC026306
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335195 ENST00000242248(uc003tjt.3 uc003tju.3 uc003tjv.3)
    ENST00000435068 ENST00000395831 ENST00000458246(uc003tjx.2 uc011kbt.1)
    ENST00000430942 ENST00000467607 ENST00000434229 ENST00000492971 ENST00000492605(uc003tjz.4)
    ENST00000418926 ENST00000492312(uc011kbu.1 uc010kxy.2) ENST00000492321
    ENST00000497300 ENST00000445616 ENST00000414235 ENST00000452049 ENST00000483644

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLM
    1 QIAGEN miScript miRNA Assays for microRNA that regulate POLM:
    hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidPOLM 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    OriGene ORF clones in mouse, rat for POLM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POLM (NM_013284)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLM
    Sirion Biotech Customized lentivirus for stable overexpression of POLM 
                         Customized lentivirus expression plasmids for stable overexpression of POLM 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for POLM
    OriGene qSTAR qPCR primer pairs in human, mouse for POLM
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POLM
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLM
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLM

    Additional mRNA sequence: 

    AF176097.1 AJ131891.2 AJ844643.1 AK023002.1 AK092801.1 AK092903.1 AK291638.1 AK294449.1 
    AK307634.1 BC026306.1 BC035685.1 BC049202.1 BC062590.1 

    17 DOTS entries:

    DT.100790802  DT.211809  DT.100720427  DT.95373549  DT.65286846  DT.100790797  DT.40238589  DT.95373552 
    DT.95373557  DT.100790801  DT.91704040  DT.100746940  DT.121122737  DT.97844644  DT.121122740  DT.100698705 
    DT.121122754 

    24/159 AceView cDNA sequences (see all 159):

    AW137352 AA832314 CR620839 AW207742 CD109226 BC062590 BM756478 BC049202 
    AA917987 AF176097 BX376518 AA046663 BE503442 AI419960 AI057140 AX747737 
    BU517199 AK092801 AV688777 BG231904 CA487434 AI738949 CR606869 BM747399 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for POLM (see all 18)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^
    SP1:                    -                                         -     -     -                             -                             -     -               
    SP2:                    -                                               -     -                             -                             -                     
    SP3:                    -                                               -     -                             -     -                       -     -     -     -   
    SP4:                    -                                                                                   -                                                   
    SP5:                    -                                         -     -     -     -     -     -     -     -                             -     -     -     -   

    ExUns: 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d · 16e · 16f · 16g
    SP1:  -                 -                                       
    SP2:  -                 -                                       
    SP3:  -                 -                                       
    SP4:                                                            
    SP5:  -                                                         


    ECgene alternative splicing isoforms for POLM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POLM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTAAAAAA
    POLM Expression
    About this image


    See POLM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POLM

    SOURCE GeneReport for Unigene cluster: Hs.596982

    UniProtKB/Swiss-Prot: DPOLM_HUMAN, Q9NP87
    Tissue specificity: Expressed in a number of tissues. Abundant in thymus

        SABiosciences Custom PCR Arrays for POLM
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for POLM gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Polm1 , 5 polymerase (DNA directed), mu1, 5 79.38(n)1
    77.08(a)1
      11 (3.87 cM)5
    541251  NM_017401.21  NP_059097.21 
     58278605 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    56(a)
    51(a)
    1 ↔ many
    1 ↔ many
    AAWZ02038928(2885-9347)
    GL343545.1(464762-472588)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc561222 similar to polymerase (DNA directed), mu 72.38(n)   393218  BC047832.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes POL46
    DNA polymerase IV, undergoes pair-wise interaction...
    14(a)
    1 → many
    III(139185-140933)


    ENSEMBL Gene Tree for POLM (if available)
    TreeFam Gene Tree for POLM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POLM gene
    POLB2  DNTT2  POLL2  
    1 SIMAP similar gene for POLM using alignment to 11 protein entries:     DPOLM_HUMAN (see all proteins):
    DNTT

    POLM for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/346 SNPs in POLM are shown (see all 346)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1877331481,2
    --44111426(+) GGTTTC/TGCCAT 1 -- int10--------
    rs1926938501,2
    --44111476(+) CCACCA/CGTCTC 1 -- int10--------
    rs1458213521,2
    --44111525(+) GCATCC/TGGCCA 1 -- int10--------
    rs1489964421,2
    --44111726(+) GATGTA/GGCACC 1 -- int10--------
    rs1842621991,2
    --44111732(+) GCACCA/GCTAAG 1 -- int10--------
    rs1892213541,2
    --44111806(+) CCTGGC/TGTGCC 1 -- int10--------
    rs558411611,2
    C,F--44111902(+) TCCTCG/ACCTAA 1 -- ut311Minor allele frequency- A:0.03EA 120
    rs1928504961,2
    --44111957(+) TCCAGA/GTAGAT 1 -- ut310--------
    rs1123836851,2
    F--44112212(+) TCTGCG/AACGGG 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs283826641,2
    C,F--44112214(-) CTCCCG/ATCGCA 1 -- ut31 ese311Minor allele frequency- A:0.13NS NA WA CSA 288

    HapMap Linkage Disequilibrium report for POLM (44111846 - 44122139 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for POLM:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv887996CNV Loss21882294
    nsv470210CNV Loss18288195
    nsv830983CNV Loss17160897
    nsv830980CNV Loss17160897
    nsv428165CNV Gain18775914
    nsv8082CNV Gain18304495

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606344    OMIM disorders: --

    6 diseases for POLM:    About MalaCards
    lung adenoma    burkitt's lymphoma    non-hodgkin lymphoma    hodgkin's lymphoma
    xeroderma pigmentosum    adenoma

    2 diseases from the University of Copenhagen DISEASES database for POLM:
    Xeroderma pigmentosum     Lung adenoma

    POLM for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for POLM gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    burkitt lymphoma 39.4 1 15520469 (1)

    Genetic Association Database (GAD): POLM
    Human Genome Epidemiology (HuGE) Navigator: POLM (1 document)

    Export disorders for POLM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POLM gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with POLM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two novel human and mouse DNA polymerases of the polX family. (PubMed id 10982892)1, 2, 3 Aoufouchi S.... Reynaud C.-A. (2000)
    2. Polymerase mu is a DNA-directed DNA/RNA polymerase. (PubMed id 12640116)1, 2, 9 Nick McElhinny S.A. and Ramsden D.A. (2003)
    3. DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells. (PubMed id 10747040)1, 2, 9 Dominguez O.... Blanco L. (2000)
    4. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (2009)
    5. Limited terminal transferase in human DNA polymerase mu defines the required balance between accuracy and efficiency in NHEJ. (PubMed id 19805281)1, 9 Andrade P....Blanco L. (2009)
    6. Involvement of DNA polymerase mu in the repair of a specific subset of DNA double-strand breaks in mammalian cells. (PubMed id 17483519)2, 9 Capp J.P....Canitrot Y. (2007)
    7. A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis. (PubMed id 16963491)1, 9 Juarez R....Blanco L. (2006)
    8. Overexpression of human DNA polymerase mu (Pol mu) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate. (PubMed id 15520469)1, 9 Ruiz J.F....Blanco L. (2004)
    9. Lesion bypass by human DNA polymerase mu reveals a template-dependent, sequence-independent nucleotidyl transferase activity. (PubMed id 14581466)1, 9 Covo S....Livneh Z. (2004)
    10. Pre-steady-state kinetic studies of the fidelity of human DNA polymerase mu. (PubMed id 15504045)1, 9 Roettger M.P....Suo Z. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27434 HGNC: 9185 AceView: POLM Ensembl:ENSG00000122678 euGenes: HUgn27434
    ECgene: POLM Kegg: 27434 H-InvDB: POLM

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POLM Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/polm/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for POLM gene:
    Search GeneIP for patents involving POLM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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