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POLL Gene

protein-coding   GIFtS: 63
GCID: GC10M103328

Polymerase (DNA Directed), Lambda

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Polymerase (DNA Directed), Lambda1 2     DNA Polymerase Lambda2
DNA Polymerase Beta-22 3     EC 2.7.7.73
DNA Polymerase Kappa2 3     EC 4.2.99.-3
BETAN2     Pol Beta23
POLKAPPA2     Pol Lambda3
DNA Polymerase Beta-N2     

External Ids:    HGNC: 91841   Entrez Gene: 273432   Ensembl: ENSG000001661697   OMIM: 6063435   UniProtKB: Q9UGP53   

Export aliases for POLL gene to outside databases

Previous GC identifers: GC10M102231 GC10M102572 GC10M103469 GC10M103003 GC10M096969


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POLL Gene:
This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a
DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role
in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been
described. (provided by RefSeq, Mar 2010)

GeneCards Summary for POLL Gene:
POLL (polymerase (DNA directed), lambda) is a protein-coding gene. Diseases associated with POLL include patent foramen ovale, and situs inversus. GO annotations related to this gene include lyase activity and DNA-directed DNA polymerase activity. An important paralog of this gene is POLB.

UniProtKB/Swiss-Prot: DPOLL_HUMAN, Q9UGP5
Function: Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give
rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a
5'-deoxyribose-5-phosphate lyase (dRP lyase) activity

Gene Wiki entry for POLL (DNA polymerase lambda) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the POLL gene promoter:
         Max1   Sp1   RREB-1   IRF-1   c-Ets-1   PPAR-gamma1   FOXO4   PPAR-gamma2   RSRFC4   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): POLL promoter sequence
   Search Chromatin IP Primers for POLL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POLL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q23

POLL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLL gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M103328:  view genomic region     (about GC identifiers)

Start:
103,338,639 bp from pter      End:
103,348,027 bp from pter
Size:
9,389 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DPOLL_HUMAN, Q9UGP5 (See protein sequence)
Recommended Name: DNA polymerase lambda  
Size: 575 amino acids; 63482 Da
Cofactor: Manganese
Subunit: Binds PCNA
Sequence caution: Sequence=BAB14050.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for POLL (see all 32):
1NZP (3D)        1RZT (3D)        1XSL (3D)        1XSN (3D)        1XSP (3D)        2BCQ (3D)    
Secondary accessions: D3DR76 Q5JQP5 Q6NUM2 Q9HA10 Q9HB35

Explore the universe of human proteins at neXtProt for POLL: NX_Q9UGP5

Explore proteomics data for POLL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POLL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001167555.1  NP_001167556.1  NP_037406.1  

    ENSEMBL proteins: 
     ENSP00000359187   ENSP00000359188   ENSP00000343102   ENSP00000299206   ENSP00000359191  
     ENSP00000400676   ENSP00000406791   ENSP00000411678   ENSP00000390093   ENSP00000400517  
     ENSP00000414293   ENSP00000359181   ENSP00000359177   ENSP00000390810   ENSP00000405331  

    POLL Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for POLL
    OriGene Protein Over-expression Lysate for POLL
    OriGene MassSpec for POLL
    OriGene Custom Protein Services for POLL
    GenScript Custom Purified and Recombinant Proteins Services for POLL
    Novus Biologicals POLL Proteins
    Novus Biologicals POLL Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for POLL
    Browse Proteins at Cloud-Clone Corp.

    POLL Antibody Products:

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    OriGene Antibodies for POLL
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    Novus Biologicals POLL Antibodies
    Abcam antibodies for POLL
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for POLL
    LSBio Antibodies in human, mouse, rat for POLL

    POLL Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for POLL
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POL: DNA polymerases

    Selected InterPro protein domains (see all 10):
     IPR010996 DNA_pol_b-like_N
     IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
     IPR028207 DNA_pol_B_palm_palm
     IPR002008 DNA_pol_X_beta-like
     IPR018944 DNA_pol_lambd_fingers_domain

    Graphical View of Domain Structure for InterPro Entry Q9UGP5

    ProtoNet protein and cluster: Q9UGP5

    3 Blocks protein domains:
    IPB002008 DNA-polymerase family X pol beta-like signature
    IPB002054 DNA polymerase family X
    IPB003583 Helix-hairpin-helix DNA-binding


    UniProtKB/Swiss-Prot: DPOLL_HUMAN, Q9UGP5
    Similarity: Belongs to the DNA polymerase type-X family
    Similarity: Contains 1 BRCT domain


    POLL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPOLL_HUMAN, Q9UGP5
    Function: Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give
    rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a
    5'-deoxyribose-5-phosphate lyase (dRP lyase) activity
    Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

         Genatlas biochemistry entry for POLL:
    polymerase (DNA-directed), lambda

         Enzyme Numbers (IUBMB): EC 4.2.99.-1 EC 2.7.7.71

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS10982892
    GO:0003824catalytic activity ----
    GO:0003887DNA-directed DNA polymerase activity NAS10982892
    GO:0016779nucleotidyltransferase activity ----
    GO:0016829lyase activity IEA--
         
    POLL for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for POLL:
     Big cells  Increased G1 DNA content  Increased cell number in S 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Poll):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  reproductive system 

    POLL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Polltm1Crey for POLL

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POLL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for POLL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POLL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POLL

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat POLL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate POLL (see all 12):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-105 hsa-let-7e hsa-let-7g hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmidPOLL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for POLL
    Predesigned siRNA for gene silencing in human, mouse, rat POLL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for POLL

    Clone
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    OriGene clones in human, mouse for POLL (see all 16)
    OriGene ORF clones in mouse, rat for POLL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): POLL (NM_013274)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLL

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for POLL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPOLL_HUMAN, Q9UGP5: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10982892

    POLL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POLL About    
    See pathways by source

    SuperPathContained pathways About
    1Resolution of Abasic Sites (AP sites)
    Base excision repair0.53
    2Non-homologous end-joining
    Non-homologous end-joining0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for POLL):
        Base excision repair
    Non-homologous end-joining


    POLL for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including POLL: 
              DNA Repair in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for POLL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for POLL (Q9UGP52, 3 ENSP000002992064) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG482, 3, ENSP000003448184MINT-6803610 I2D: score=1 STRING: ENSP00000344818
    XRCC1P188872, 3, ENSP000002628874MINT-7294920 I2D: score=1 STRING: ENSP00000262887
    PCNAP120043, ENSP000003684384I2D: score=2 STRING: ENSP00000368438
    PSMD12O002323, ENSP000003484424I2D: score=2 STRING: ENSP00000348442
    PSMD13Q9UNM63, ENSP000003969374I2D: score=2 STRING: ENSP00000396937
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication NAS10982892
    GO:0006261DNA-dependent DNA replication NAS10982892
    GO:0006281DNA repair ----
    GO:0006289nucleotide-excision repair IDA10982892
    GO:0016446somatic hypermutation of immunoglobulin genes NAS10982892

    POLL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POLL (DPOLL)

    7 HMDB Compounds for POLL    About this table
    CompoundSynonyms CAS #PubMed Ids
    Manganesemanganese 7439-96-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Thymidine 5'-triphosphate2'-Deoxythymidine 5'-triphosphate (see all 13)365-08-2--
    dATP2'-Deoxy-5'-ATP (see all 8)1927-31-7--
    dCTP2'-deoxycytidine-5'-triphosphate (see all 4)2056-98-6--
    dGTP2'-Deoxyguanosine 5'-triphosphate (see all 4)2564-35-4--

    3 Novoseek inferred chemical compound relationships for POLL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    petasiphenol 94.8 4 14719082 (2), 16483311 (1), 14599551 (1)
    polynucleotide 45.5 1 16822725 (1)
    curcumin 42.9 5 16483311 (2), 16236265 (1)



    POLL for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for POLL gene (3 alternative transcripts): 
    NM_001174084.1  NM_001174085.1  NM_013274.3  

    Unigene Cluster for POLL:

    Polymerase (DNA directed), lambda
    Hs.523230  [show with all ESTs]
    Unigene Representative Sequence: AK128521
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000463515 ENST00000370168(uc001ktd.1) ENST00000370169 ENST00000339310(uc001kte.1 uc001kth.1)
    ENST00000299206 ENST00000370172(uc001ktl.3) ENST00000415897 ENST00000485369
    ENST00000429502 ENST00000470140 ENST00000426919 ENST00000454524 ENST00000413344
    ENST00000461587 ENST00000430045 ENST00000370162(uc001ktg.1 uc001ktj.2 uc010qqb.2 uc001ktf.3 uc001kti.2 uc001ktm.3 uc010qqc.2 uc010qqa.2)
    ENST00000370158 ENST00000456836
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate POLL (see all 12):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-105 hsa-let-7e hsa-let-7g hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmidPOLL 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for POLL
    Predesigned siRNA for gene silencing in human, mouse, rat POLL
    Clone
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    OriGene clones in human, mouse for POLL (see all 16)
    OriGene ORF clones in mouse, rat for POLL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): POLL (NM_013274)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLL
    Primer
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    OriGene qPCR primer pairs and template standards for POLL
    OriGene qSTAR qPCR primer pairs in human, mouse for POLL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POLL
      QuantiTect SYBR Green Assays in human, mouse, rat POLL
      QuantiFast Probe-based Assays in human, mouse, rat POLL

    Additional mRNA sequence: 

    AF161019.1 AF218027.1 AF283478.1 AJ131890.1 AJ844641.1 AJ844642.1 AK021600.1 AK022476.1 
    AK091106.1 AK094956.1 AK127896.1 AK128521.1 AK292225.1 AK293421.1 AK293602.1 AK293657.1 
    AK300862.1 AY302442.1 BC003548.1 BC068529.1 NR_033406.1 

    Selected DOTS entries (see all 26):

    DT.101975369  DT.121285857  DT.451909  DT.121285847  DT.100803462  DT.101955938  DT.97845165  DT.100803466 
    DT.40274159  DT.101982265  DT.97845163  DT.95225959  DT.100803463  DT.121285895  DT.92032975  DT.95225986 
    DT.100803469  DT.92430694  DT.100723724  DT.121285859  DT.121285850  DT.92430693  DT.100027841  DT.102829578 

    Selected AceView cDNA sequences (see all 184):

    BC003548 BI091406 AK094956 BX384565 BQ954336 AW673654 BG149290 AJ131890 
    BU184350 BU195355 BP369475 AF218027 AU141478 AI199486 BG764790 AK022476 
    CA430338 CA405484 AU122737 CR615868 BQ932866 BI906886 BC068529 AI922408 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for POLL (see all 37)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c · 7d ·
    SP1:                                -     -     -     -     -     -     -                             -                                                         
    SP2:                                -     -     -     -     -     -     -     -     -     -     -                                                               
    SP3:                                                              -     -                             -                                                         
    SP4:                                                                    -                             -                                                         
    SP5:                                                                                                  -                                                         

    ExUns: 7e · 7f ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b · 12c · 12d · 12e · 12f ^ 13a · 13b · 13c · 13d · 13e · 13f · 13g
    SP1:        -                                         -                       -                       -     -     -                                       
    SP2:        -                                         -                       -                       -     -     -                                       
    SP3:        -                                         -                       -                       -     -     -                                       
    SP4:        -                                         -                       -                       -     -     -                                       
    SP5:        -           -     -     -     -           -                       -                       -     -     -                                       


    ECgene alternative splicing isoforms for POLL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    POLL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTCCCTCT
    POLL Expression
    About this image

    POLL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POLL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523230

    UniProtKB/Swiss-Prot: DPOLL_HUMAN, Q9UGP5
    Tissue specificity: Expressed in a number of tissues. Abundant in testis

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for POLL gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Poll1 , 5 polymerase (DNA directed), lambda1, 5 84.12(n)1
    82.55(a)1
      19 (38.75 cM)5
    566261  NM_020032.21  NP_064416.11 
     455522755 
    chicken
    (Gallus gallus)
    Aves POLL1 polymerase (DNA directed), lambda 68.58(n)
    66.96(a)
      423853  XM_001232208.3  XP_001232209.3 
    lizard
    (Anolis carolinensis)
    Reptilia POLL6
    polymerase (DNA directed), lambda
    64(a)
    1 ↔ 1
    GL343239.1(1085527-1101646)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.60672 Xenopus laevis transcribed sequence with weak similarity more 75.48(n)    BM191146.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufe49a042 Danio rerio cDNA clone MGC66320 IMAGE5601740, complete more 74.36(n)    BC055597.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G105201 AT1G10520 48.27(n)
    39.63(a)
      837592  NM_100926.2  NP_172522.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g02372001 Os06g0237200 45.96(n)
    34.27(a)
      4340604  NM_001063782.1  NP_001057247.1 


    ENSEMBL Gene Tree for POLL (if available)
    TreeFam Gene Tree for POLL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for POLL gene
    POLB2  DNTT2  POLM2  
    2 SIMAP similar genes for POLL using alignment to 15 protein entries:     DPOLL_HUMAN (see all proteins):
    DNA pol beta    POLB

    POLL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POLL (see all 296)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37304621,2
    C,F--96976538(-) AGTTACAACA/
            
    GTAGT
    4 -- int12Minor allele frequency- -:0.21NS CSA 180
    rs357805281,2
    C--96980418(+) ACTGG-/AAAAAA 4 -- us2k12Minor allele frequency- A:0.25NA 4
    rs1924103411,2
    --103700814(+) GGCTGA/GGGCAC 4 -- ut31 nc-transcript-variant0--------
    rs10553641,2
    C,F,A--103700843(+) AGCTGA/C/GCCAGG 8 -- ut31 nc-transcript-variantese311MN NA NS CSA WA EA 839
    rs10553621,2
    C,F,A,H--103700846(+) TGCCCA/GGGAAG 4 -- ut31 nc-transcript-variantese323Minor allele frequency- G:0.18MN NS EA NA CSA WA 2826
    rs1846245891,2
    --103700858(+) AGGACA/GGATAG 4 -- ut31 nc-transcript-variant0--------
    rs1405284281,2
    --103701008(+) CTGGGA/GCTTCA 4 -- ut31 nc-transcript-variant0--------
    rs1873675281,2
    --103701127(+) GGCTGA/GGCAGA 4 -- ut31 nc-transcript-variant0--------
    rs1918176371,2
    --103701144(+) GAGCCA/GGGCAG 4 -- ut31 nc-transcript-variant0--------
    rs558000991,2
    C--103701179(+) GCTTCA/GGGCCC 4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for POLL (103338639 - 103348027 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for POLL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527185CNV Loss19592680
    nsv526529CNV Loss19592680
    esv2750847CNV Gain17911159
    nsv895967CNV Gain21882294

    Human Gene Mutation Database (HGMD): POLL
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing POLL
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606343    OMIM disorders: --

    11 diseases for POLL:    
    About MalaCards
    patent foramen ovale    situs inversus    primary ciliary dyskinesia    hydrocephalus
    male infertility    sinusitis    infertility    chronic lymphocytic leukemia
    lung cancer    alzheimer's disease    leukemia

    1 disease from the University of Copenhagen DISEASES database for POLL:
    Patent foramen ovale

    POLL for disorders           About GeneDecksing

    Genetic Association Database (GAD): POLL
    Human Genome Epidemiology (HuGE) Navigator: POLL (11 documents)

    Export disorders for POLL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POLL gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with POLL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A. (PubMed id 15537631)1, 2, 9 Maga G....Hubscher U. (J. Biol. Chem. 2005)
    2. The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1. (PubMed id 15358682)1, 2, 9 Maga G.... Huebscher U. (FASEB J. 2004)
    3. A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology. (PubMed id 14992725)1, 2, 9 Garcia-Diaz M....Pedersen L.C. (Mol. Cell 2004)
    4. Solution structure of the lyase domain of human DNA polymerase lambda. (PubMed id 12911298)1, 2, 9 DeRose E.F.... London R.E. (Biochemistry 2003)
    5. Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study. (PubMed id 12809503)1, 2, 9 Blanca G.... Maga G. (Biochemistry 2003)
    6. Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair. (PubMed id 11457865)1, 2, 9 Garcia-Diaz M.... Blanco L. (J. Biol. Chem. 2001)
    7. Identification and characterization of human DNA polymerase beta 2, a DNA polymerase beta-related enzyme. (PubMed id 10887191)1, 2, 9 Nagasawa K.I.... Nakanishi M. (J. Biol. Chem. 2000)
    8. Human DNA polymerase lambda is a proficient extender of primer ends paired to 7,8-dihydro-8-oxoguanine. (PubMed id 17686665)1, 3, 9 Picher A.J. and Blanco L. (DNA Repair (Amst.) 2007)
    9. Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities. (PubMed id 14627824)1, 2, 9 Shevelev I.... Maga G. (Nucleic Acids Res. 2003)
    10. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (Carcinogenesis 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27343 HGNC: 9184 AceView: POLL Ensembl:ENSG00000166169 euGenes: HUgn27343
    ECgene: POLL Kegg: 27343 H-InvDB: POLL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for POLL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for POLL Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/poll/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for POLL gene:
    Search GeneIP for patents involving POLL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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