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Aliases for POLL Gene

Aliases for POLL Gene

  • Polymerase (DNA Directed), Lambda 2 3
  • DNA Polymerase Beta-2 3 4
  • DNA Polymerase Kappa 3 4
  • DNA Polymerase Beta-N 3
  • DNA Polymerase Lambda 3
  • EC 4.2.99.- 4
  • Pol Lambda 4
  • EC 2.7.7.7 4
  • Pol Beta2 4
  • POLKAPPA 3
  • BETAN 3

External Ids for POLL Gene

Previous GeneCards Identifiers for POLL Gene

  • GC10M102231
  • GC10M102572
  • GC10M103469
  • GC10M103003
  • GC10M103328
  • GC10M096969

Summaries for POLL Gene

Entrez Gene Summary for POLL Gene

  • This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010]

GeneCards Summary for POLL Gene

POLL (Polymerase (DNA Directed), Lambda) is a Protein Coding gene. Diseases associated with POLL include patent foramen ovale. Among its related pathways are Resolution of Abasic Sites (AP sites) and Non-homologous end-joining. GO annotations related to this gene include DNA-directed DNA polymerase activity and lyase activity. An important paralog of this gene is POLB.

UniProtKB/Swiss-Prot for POLL Gene

  • Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5-deoxyribose-5-phosphate lyase (dRP lyase) activity.

Gene Wiki entry for POLL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLL Gene

Genomics for POLL Gene

Regulatory Elements for POLL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for POLL Gene

Start:
101,578,882 bp from pter
End:
101,588,270 bp from pter
Size:
9,389 bases
Orientation:
Minus strand

Genomic View for POLL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POLL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLL Gene

Proteins for POLL Gene

  • Protein details for POLL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGP5-DPOLL_HUMAN
    Recommended name:
    DNA polymerase lambda
    Protein Accession:
    Q9UGP5
    Secondary Accessions:
    • D3DR76
    • Q5JQP5
    • Q6NUM2
    • Q9BTN8
    • Q9HA10
    • Q9HB35

    Protein attributes for POLL Gene

    Size:
    575 amino acids
    Molecular mass:
    63482 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Binds PCNA.
    SequenceCaution:
    • Sequence=BAB14050.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for POLL Gene

    Alternative splice isoforms for POLL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLL Gene

Proteomics data for POLL Gene at MOPED

Post-translational modifications for POLL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for POLL Gene

Domains for POLL Gene

Gene Families for POLL Gene

HGNC:
  • POL :DNA polymerases

Graphical View of Domain Structure for InterPro Entry

Q9UGP5

UniProtKB/Swiss-Prot:

DPOLL_HUMAN :
  • Q9UGP5
Domain:
  • Contains 1 BRCT domain.
Family:
  • Belongs to the DNA polymerase type-X family.
genes like me logo Genes that share domains with POLL: view

Function for POLL Gene

Molecular function for POLL Gene

GENATLAS Biochemistry: polymerase (DNA-directed), lambda
UniProtKB/Swiss-Prot CatalyticActivity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
UniProtKB/Swiss-Prot Function: Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5-deoxyribose-5-phosphate lyase (dRP lyase) activity.

Enzyme Numbers (IUBMB) for POLL Gene

Gene Ontology (GO) - Molecular Function for POLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 10982892
GO:0003887 DNA-directed DNA polymerase activity NAS 10982892
GO:0005515 protein binding IPI 25416956
GO:0016829 lyase activity IEA --
GO:0034061 DNA polymerase activity --
genes like me logo Genes that share ontologies with POLL: view
genes like me logo Genes that share phenotypes with POLL: view

Animal Models for POLL Gene

MGI Knock Outs for POLL:

Animal Model Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for POLL Gene

Localization for POLL Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLL Gene COMPARTMENTS Subcellular localization image for POLL gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for POLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10982892
genes like me logo Genes that share ontologies with POLL: view

Pathways for POLL Gene

genes like me logo Genes that share pathways with POLL: view

Pathways by source for POLL Gene

2 KEGG pathways for POLL Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for POLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication NAS 10982892
GO:0006281 DNA repair --
GO:0006289 nucleotide-excision repair IDA 10982892
GO:0016446 somatic hypermutation of immunoglobulin genes NAS 10982892
GO:0071897 DNA biosynthetic process IEA --
genes like me logo Genes that share ontologies with POLL: view

Compounds for POLL Gene

(7) HMDB Compounds for POLL Gene

Compound Synonyms Cas Number PubMed IDs
dATP
  • 2'-Deoxy-5'-ATP
1927-31-7
dCTP
  • 2'-deoxycytidine-5'-triphosphate
2056-98-6
dGTP
  • 2'-Deoxyguanosine 5'-triphosphate
2564-35-4
Manganese
  • manganese
7439-96-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2

(3) Novoseek inferred chemical compound relationships for POLL Gene

Compound -log(P) Hits PubMed IDs
petasiphenol 94.8 4
polynucleotide 45.5 1
curcumin 42.9 3
genes like me logo Genes that share compounds with POLL: view

Transcripts for POLL Gene

Unigene Clusters for POLL Gene

Polymerase (DNA directed), lambda:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POLL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLL Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c · 7d ·
SP1: - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: -
SP12:
SP13:
SP14: - - - - - - - - - - -
SP15: - - - - - - - -
SP16: - - - - - - - - -
SP17: - - - - - - - - - - - - - - -
SP18: - - - - - - - -
SP19: - - - - - - - - - - - -
SP20: - - - - - - - - - - - - - - - - -
SP21: - - - - - - - - - - - -
SP22: - - -
SP23: - - - -
SP24: - - - - - - - - - - - - - - - -
SP25: - - - - - - - - - - - -
SP26: - - - - - -
SP27: - - - - - - - - - - - -
SP28: - - - - - - - - - - - - -
SP29: - - - - - - -
SP30: - - -
SP31: - - - - -
SP32: - - - - - - - - - - - - -
SP33: - - - -
SP34:
SP35:
SP36:
SP37: - - - - - - - - - -

ExUns: 7e · 7f ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b · 12c · 12d · 12e · 12f ^ 13a · 13b · 13c · 13d · 13e · 13f · 13g
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - - - - -
SP11: -
SP12: - - - - - - - -
SP13: - - - -
SP14:
SP15:
SP16:
SP17: - - - - - - - - -
SP18:
SP19: -
SP20: - - - - - - - - - -
SP21: -
SP22:
SP23: - - - - - - - - -
SP24: - -
SP25:
SP26:
SP27: - - - - - - - - -
SP28: - - - - - - - - -
SP29:
SP30:
SP31:
SP32: - -
SP33: - -
SP34: - - - -
SP35: - - -
SP36:
SP37: - - - - - - - - - - - - -

Relevant External Links for POLL Gene

GeneLoc Exon Structure for
POLL
ECgene alternative splicing isoforms for
POLL

Expression for POLL Gene

mRNA expression in normal human tissues for POLL Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLL Gene

SOURCE GeneReport for Unigene cluster for POLL Gene Hs.523230

mRNA Expression by UniProt/SwissProt for POLL Gene

Q9UGP5-DPOLL_HUMAN
Tissue specificity: Expressed in a number of tissues. Abundant in testis
genes like me logo Genes that share expressions with POLL: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for POLL Gene

Orthologs for POLL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLL 35
  • 99.42 (n)
  • 99.13 (a)
POLL 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POLL 35
  • 86.72 (n)
  • 85.04 (a)
POLL 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLL 35
  • 86.61 (n)
  • 85.57 (a)
POLL 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Poll 35
  • 84.12 (n)
  • 82.55 (a)
Poll 16
Poll 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLL 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLL 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Poll 35
  • 84.7 (n)
  • 82.55 (a)
chicken
(Gallus gallus)
Aves POLL 35
  • 68.58 (n)
  • 66.96 (a)
POLL 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLL 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6067 35
tropical clawed frog
(Silurana tropicalis)
Amphibia poll 35
  • 62.11 (n)
  • 61.23 (a)
Str.3820 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3101 35
zebrafish
(Danio rerio)
Actinopterygii poll 35
  • 58.41 (n)
  • 58.53 (a)
ved 36
  • 3 (a)
OneToOne
wufe49a04 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POL4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G10520 35
  • 48.27 (n)
  • 39.63 (a)
rice
(Oryza sativa)
Liliopsida Os06g0237200 35
  • 45.96 (n)
  • 34.27 (a)
Species with no ortholog for POLL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POLL Gene

ENSEMBL:
Gene Tree for POLL (if available)
TreeFam:
Gene Tree for POLL (if available)

Paralogs for POLL Gene

Paralogs for POLL Gene

genes like me logo Genes that share paralogs with POLL: view

Variants for POLL Gene

Sequence variations from dbSNP and Humsavar for POLL Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1055362 -- 101,578,976(+) TGCCC(A/G)GGAAG utr-variant-3-prime, nc-transcript-variant
rs1055364 -- 101,578,973(+) AGCTG(A/C/G)CCAGG utr-variant-3-prime, nc-transcript-variant
rs1549067 -- 101,581,161(+) ACTGA(A/G)AATTC intron-variant
rs3095795 -- 101,580,692(+) TGCCC(C/T)GTGGA intron-variant
rs3095796 -- 101,583,757(+) AGCTG(A/G)CTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLL Gene

Variant ID Type Subtype PubMed ID
esv2750847 CNV Gain 17911159
nsv895967 CNV Gain 21882294
nsv526529 CNV Loss 19592680
nsv527185 CNV Loss 19592680

Relevant External Links for POLL Gene

HapMap Linkage Disequilibrium report
POLL
Human Gene Mutation Database (HGMD)
POLL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLL Gene

Disorders for POLL Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for POLL Gene including...

Search for POLL Gene in MalaCards »

(1) University of Copenhagen DISEASES for POLL Gene

Relevant External Links for POLL

Genetic Association Database (GAD)
POLL
Human Genome Epidemiology (HuGE) Navigator
POLL
genes like me logo Genes that share disorders with POLL: view

No data available for UniProtKB/Swiss-Prot for POLL Gene

Publications for POLL Gene

  1. Identification and characterization of human DNA polymerase beta 2, a DNA polymerase beta-related enzyme. (PMID: 10887191) Nagasawa K.I. … Nakanishi M. (J. Biol. Chem. 2000) 3 4 23
  2. Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair. (PMID: 11457865) Garcia-Diaz M. … Blanco L. (J. Biol. Chem. 2001) 3 4 23
  3. Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study. (PMID: 12809503) Blanca G. … Maga G. (Biochemistry 2003) 3 4 23
  4. Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities. (PMID: 14627824) Shevelev I. … Maga G. (Nucleic Acids Res. 2003) 3 4 23
  5. Solution structure of the lyase domain of human DNA polymerase lambda. (PMID: 12911298) DeRose E.F. … London R.E. (Biochemistry 2003) 3 4 23

Products for POLL Gene

Sources for POLL Gene

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