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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POLL Gene

protein-coding   GIFtS: 63
GCID: GC10M103328

polymerase (DNA directed), lambda
 Explore 13 diseases affiliated with
POLL via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for POLL    

Aliases
for POLL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Polymerase (DNA Directed), Lambda1 2     DNA Polymerase Lambda2
DNA Polymerase Beta-22 3     EC 2.7.7.73
DNA Polymerase Kappa2 3     EC 4.2.99.-3
BETAN2     Pol Beta23
POLKAPPA2     Pol Lambda3
DNA Polymerase Beta-N2     

External Ids:    HGNC: 91841   Entrez Gene: 273432   Ensembl: ENSG000001661697   OMIM: 6063435   UniProtKB: Q9UGP53   
ORGUL members:         
NONCODE:n409240    

Export aliases for POLL gene to outside databases

Previous GC identifers: GC10M102231 GC10M102572 GC10M103469 GC10M103003 GC10M096969


Summaries
for POLL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for POLL:
This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA
strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in
non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been
described. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: DPOLL_HUMAN, Q9UGP5
Function: Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to
abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a
5'-deoxyribose-5-phosphate lyase (dRP lyase) activity

Gene Wiki entry for POLL (DNA polymerase lambda)


Genomic Views
for POLL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POLL gene promoter:
         Max1   Sp1   RREB-1   IRF-1   c-Ets-1   PPAR-gamma1   FOXO4   PPAR-gamma2   RSRFC4   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): POLL promoter sequence
   Search SABiosciences Chromatin IP Primers for POLL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q23

POLL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLL gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M103328:  view genomic region     (about GC identifiers)

Start:
 103,338,639 bp from pter      End:
 103,348,027 bp from pter
Size:
 9,389 bases      Orientation:
 minus strand

Proteins
for POLL gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DPOLL_HUMAN, Q9UGP5 (See protein sequence)
Recommended Name: DNA polymerase lambda  
Size: 575 amino acids; 63482 Da
Cofactor: Manganese
Subunit: Binds PCNA
Subcellular location: Nucleus
Sequence caution: Sequence=BAB14050.1; Type=Erroneous initiation;
6/32 PDB 3D structures from and Proteopedia for POLL (see all 32):
1NZP (3D)        1RZT (3D)        1XSL (3D)        1XSN (3D)        1XSP (3D)        2BCQ (3D)    
Secondary accessions: D3DR76 Q5JQP5 Q6NUM2 Q9HA10 Q9HB35

Explore the universe of human proteins at neXtProt for POLL: NX_Q9UGP5

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UGP5

    • POLL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001167555.1  NP_001167556.1  NP_037406.1  

    ENSEMBL proteins: 
     ENSP00000299206   ENSP00000359193   ENSP00000359188   ENSP00000343102   ENSP00000359191  
     ENSP00000359187   ENSP00000400676   ENSP00000406791   ENSP00000411678   ENSP00000390093  
     ENSP00000400517   ENSP00000414293   ENSP00000359181   ENSP00000359177   ENSP00000390810  
     ENSP00000405331  

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    Novus Biologicals POLL Lysate
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    ProSpec Recombinant Protein for POLL
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10982892


    POLL for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for POLL

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    Protein Domains /
    Families
    for POLL gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    POLL for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR010996 DNA_pol_b-like_N
     IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
     IPR002008 DNA_pol_X_beta-like
     IPR018944 DNA_pol_lambd_fingers_domain
     IPR019843 DNA_pol-X_BS

    Graphical View of Domain Structure for InterPro Entry Q9UGP5

    ProtoNet protein and cluster: Q9UGP5

    3 Blocks protein families:
    IPB002008 DNA-polymerase family X pol beta-like signature
    IPB002054 DNA polymerase family X
    IPB003583 Helix-hairpin-helix DNA-binding


    UniProtKB/Swiss-Prot: DPOLL_HUMAN, Q9UGP5
    Similarity: Belongs to the DNA polymerase type-X family
    Similarity: Contains 1 BRCT domain


    Function
    for POLL gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DPOLL_HUMAN, Q9UGP5
    Function: Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to
    abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a
    5'-deoxyribose-5-phosphate lyase (dRP lyase) activity
    Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

         Genatlas biochemistry entry for POLL:
    polymerase (DNA-directed), lambda

    Enzyme Numbers (IUBMB): EC 4.2.99.-1 EC 2.7.7.71

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate POLL (see all 12):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-105 hsa-let-7e hsa-let-7g hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmid: POLL 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLL (see all 7)
    OriGene shRNA RFP: POLL
    OriGene siRNA: POLL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLL

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for POLL

    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS10982892
    GO:0003824catalytic activity ----
    GO:0003887DNA-directed DNA polymerase activity NAS10982892
    GO:0016779nucleotidyltransferase activity ----
    GO:0016829lyase activity IEA--


    POLL for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for POLL:
     Big cells  Increased G1 DNA content  Increased cell number in S 

    Animal Models:
         Mouse knock-out Polltm1Crey for POLL
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Poll):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  reproductive system 

    POLL for phenotypes           About GeneDecksing


    Pathways & Interactions
    for POLL gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Non-homologous end-joining
    		Non-homologous end-joining1.00
    2Resolution of Abasic Sites (AP sites)
    		Base excision repair0.51

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for POLL):
        Base excision repair
    Non-homologous end-joining


    POLL for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POLL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/38 Interacting proteins for POLL (Q9UGP52, 3 ENSP000002992064) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG482, 3, ENSP000003448184MINT-6803610 I2D: score=1 STRING: ENSP00000344818
    XRCC1P188872, 3, ENSP000002628874MINT-7294920 I2D: score=1 STRING: ENSP00000262887
    PCNAP120043, ENSP000003684384I2D: score=2 STRING: ENSP00000368438
    CDK2P249413, ENSP000002669704I2D: score=1 STRING: ENSP00000266970
    REV1Q9UBZ93, ENSP000002584284I2D: score=1 STRING: ENSP00000258428
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication NAS10982892
    GO:0006281DNA repair ----
    GO:0006289nucleotide-excision repair IDA10982892
    GO:0016446somatic hypermutation of immunoglobulin genes NAS10982892


    POLL for ontologies           About GeneDecksing



    Drugs & Compounds
    for POLL gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    POLL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for POLL

    7 HMDB Compounds for POLL    About this table
    CompoundSynonyms CAS #PubMed Ids
    Manganesemanganese 7439-96-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Thymidine 5'-triphosphate2'-Deoxythymidine 5'-triphosphate (see all 13)365-08-2--
    dATP2'-Deoxy-5'-ATP (see all 8)1927-31-7--
    dCTP2'-deoxycytidine-5'-triphosphate (see all 4)2056-98-6--
    dGTP2'-Deoxyguanosine 5'-triphosphate (see all 4)2564-35-4--
    3 Novoseek chemical compound relationships for POLL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    petasiphenol 94.8 4 14719082 (2), 16483311 (1), 14599551 (1)
    polynucleotide 45.5 1 16822725 (1)
    curcumin 42.9 5 16483311 (2), 16236265 (1)

    Search CenterWatch for drugs/clinical trials and news about POLL / DPOLL 

    Transcripts
    for POLL gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for POLL gene (3 alternative transcripts): 
    NM_001174084.1  NM_001174085.1  NM_013274.3  

    Unigene Cluster for POLL:

    Polymerase (DNA directed), lambda
    Hs.523230  [show with all ESTs]
    Unigene Representative Sequence: AK128521
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000299206 ENST00000370174 ENST00000370169 ENST00000339310(uc001kte.1 uc001kth.1)
    ENST00000370172(uc001ktl.3) ENST00000370168(uc001ktd.1) ENST00000463515
    ENST00000415897 ENST00000485369 ENST00000429502 ENST00000470140 ENST00000426919
    ENST00000454524 ENST00000413344 ENST00000461587 ENST00000430045 ENST00000370162(uc001ktg.1 uc001ktj.2 uc010qqb.2 uc001ktf.3 uc001kti.2 uc001ktm.3 uc010qqc.2 uc010qqa.2)
    ENST00000370158

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLL
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate POLL (see all 12):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-105 hsa-let-7e hsa-let-7g hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmid: POLL 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLL (see all 7)
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    Clone
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    Additional cDNA sequence: 

    AF161019.1 AF218027.1 AF283478.1 AJ131890.1 AJ844641.1 AJ844642.1 AK021600.1 AK022476.1 
    AK091106.1 AK094956.1 AK127896.1 AK128521.1 AK292225.1 AK293421.1 AK293602.1 AK293657.1 
    AK300862.1 AY302442.1 BC003548.1 BC068529.1 NR_033406.1 

    24/26 DOTS entries (see all 26):

    DT.101975369  DT.121285857  DT.451909  DT.121285847  DT.100803462  DT.101955938  DT.97845165  DT.100803466 
    DT.40274159  DT.101982265  DT.97845163  DT.95225959  DT.100803463  DT.121285895  DT.92032975  DT.95225986 
    DT.100803469  DT.92430694  DT.100723724  DT.121285859  DT.121285850  DT.92430693  DT.100027841  DT.102829578 

    24/184 AceView cDNA sequences (see all 184):

    BU195355 CB151800 BQ232479 BI906886 BC003548 BX374468 AF161019 AW673654 
    BP342191 AJ131890 BQ954336 CA406519 CA425908 BG149290 BX384565 AU122737 
    BP357890 BP369475 AK094956 BG764790 AI199486 AI922408 CA430338 AU141478 

    GeneLoc Exon Structure

    5/37 Alternative Splicing Database (ASD) splice patterns (SP) for POLL (see all 37)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c · 7d ·
    SP1:                                -     -     -     -     -     -     -                             -                                                         
    SP2:                                -     -     -     -     -     -     -     -     -     -     -                                                               
    SP3:                                                              -     -                             -                                                         
    SP4:                                                                    -                             -                                                         
    SP5:                                                                                                  -                                                         

    ExUns: 7e · 7f ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b · 12c · 12d · 12e · 12f ^ 13a · 13b · 13c · 13d · 13e · 13f · 13g
    SP1:        -                                         -                       -                       -     -     -                                       
    SP2:        -                                         -                       -                       -     -     -                                       
    SP3:        -                                         -                       -                       -     -     -                                       
    SP4:        -                                         -                       -                       -     -     -                                       
    SP5:        -           -     -     -     -           -                       -                       -     -     -                                       


    ECgene alternative splicing isoforms for POLL

    Expression
    for POLL gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POLL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTTCCCTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See POLL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POLL

    SOURCE GeneReport for Unigene cluster: Hs.523230

    UniProtKB/Swiss-Prot: DPOLL_HUMAN, Q9UGP5
    Tissue specificity: Expressed in a number of tissues. Abundant in testis

        SABiosciences Expression via Pathway-Focused PCR Array including POLL: 
              DNA Repair in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for POLL gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for POLL gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Poll1 , 5 polymerase (DNA directed), lambda1, 5 84.12(n)1
    82.72(a)1    		   19 (38.75 cM)5
    566261  NM_020032.21  NP_064416.11 
     455522755 
    chicken
    (Gallus gallus)    		 Aves POLL1 polymerase (DNA directed), lambda 70.28(n)
    68.79(a)    		   423853  XM_001232208.2  XP_001232209.2 
    lizard
    (Anolis carolinensis)    		 Reptilia POLL6
    		 --
    		 63(a)
    		 1 ↔ 1
    		 GL343239.1(1085527-1097967)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.60672 Xenopus laevis transcribed sequence with weak similarity more 75.48(n)    BM191146.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufe49a042 Danio rerio cDNA clone MGC66320 IMAGE5601740, complete more 74.36(n)    BC055597.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G105201 DNA polymerase lambda subunit 44.18(n)
    34.12(a)    		   837592  NM_100926.2  NP_172522.2 
    rice
    (Oryza sativa)    		 Liliopsida Os06g02372001 hypothetical protein 45.88(n)
    34.06(a)    		   4340604  NM_001063782.1  NP_001057247.1 


    ENSEMBL Gene Tree for POLL (if available)
    TreeFam Gene Tree for POLL (if available) 

    Paralogs
    for POLL gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POLL gene
    POLB2  POLM2  DNTT2  
    2 SIMAP similar genes for POLL using alignment to 16 protein entries:     DPOLL_HUMAN (see all proteins):
    DNA pol beta    POLB

    POLL for paralogs           About GeneDecksing



    Genomic Variants
    for POLL gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/159 NCBI SNPs in POLL are shown (see all 159)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs37304781,2
    		C,F,H,--96969739(-) ACTCCC/TTCCAG 4 -- ut31 nc-transcript-variant19Minor allele frequency- T:0.08NS EA NA WA EU 2483
    rs556734101,2
    		--96971619(+) TCCACA/GTGAGT 4 -- int10--------
    rs37304701,2
    		C,F,H,--96972029(-) ATGTAA/CAAGCT 4 -- int16Minor allele frequency- C:0.01NS EA WA 708
    rs37304691,2
    		H--96972109(-) GTTGCT/GTTTAA 4 -- int15Minor allele frequency- G:0.00NS EA 584
    rs798199321,2
    		F--96972178(+) TTTTTA/C/TAGACA 4 -- int12NA CSA 4
    rs763751631,2
    		F--96972753(+) AAAATT/ATTAAA 4 -- int11Minor allele frequency- A:0.50NA 4
    rs557271301,2
    		C--96973239(+) ACTTCA/GGAAGC 7 R * stg10--------
    rs37304671,2
    		C,F,--96973380(-) AGACCC/AAACTG 4 -- int17Minor allele frequency- A:0.07NS NA 446
    rs30957961,2
    		C,F,--96974111(+) AGCTGA/GCTCCT 4 -- int15Minor allele frequency- G:0.20NA WA 126
    rs37304641,2
    		C,F,H,--96974648(-) ccgtgT/Ataccc 4 -- int15Minor allele frequency- A:0.01NS EA 594

    HapMap Linkage Disequilibrium report for POLL (103338639 - 103348027 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for POLL
         1 CNV: 8666
    Human Gene Mutation Database (HGMD): POLL

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    Disorders / Diseases
    for POLL gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    POLL for disorders           About GeneDecksing

    OMIM gene information: 606343    OMIM disorders: --

    13 diseases for POLL:    About MalaCards
    patent foramen ovale    ciliary dyskinesia    primary ciliary dyskinesia    situs inversus
    male infertility    chronic lymphocytic leukemia    lymphocytic leukemia    hydrocephalus
    infertility    sinusitis    alzheimer's disease    leukemia
    lung cancer

    1 disease from the University of Copenhagen DISEASES database for POLL:
    Patent foramen ovale
    Human Genome Epidemiology (HuGE) Navigator: POLL (11 documents)

    Export disorders for POLL gene to outside databases

    Publications
    for POLL gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POLL gene, integrated from 9 sources (see all 103):
    (articles sorted by number of sources associating them with POLL)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A. (PubMed id 15537631)1, 2, 9 Maga G....Hubscher U. (2005)
    2. The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1. (PubMed id 15358682)1, 2, 9 Maga G.... Huebscher U. (2004)
    3. A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology. (PubMed id 14992725)1, 2, 9 Garcia-Diaz M....Pedersen L.C. (2004)
    4. Solution structure of the lyase domain of human DNA polymerase lambda. (PubMed id 12911298)1, 2, 9 DeRose E.F.... London R.E. (2003)
    5. Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study. (PubMed id 12809503)1, 2, 9 Blanca G.... Maga G. (2003)
    6. Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair. (PubMed id 11457865)1, 2, 9 Garcia-Diaz M.... Blanco L. (2001)
    7. Identification and characterization of human DNA polymerase beta 2, a DNA polymerase beta-related enzyme. (PubMed id 10887191)1, 2, 9 Nagasawa K.I.... Nakanishi M. (2000)
    8. Human DNA polymerase lambda is a proficient extender of primer ends paired to 7,8-dihydro-8-oxoguanine. (PubMed id 17686665)1, 3, 9 Picher A.J. and Blanco L. (2007)
    9. Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities. (PubMed id 14627824)1, 2, 9 Shevelev I.... Maga G. (2003)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    External Searches for POLL gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing POLL gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27343 HGNC: 9184 AceView: POLL Ensembl:ENSG00000166169 euGenes: HUgn27343
    ECgene: POLL Kegg: 27343 H-InvDB: POLL

    Other Databases showing POLL gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing POLL gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POLL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for POLL Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/poll/

    Intellectual Property
    for POLL gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for POLL gene:
    Search GeneIP for patents involving POLL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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