Aliases for POLK Gene
External Ids for POLK Gene
Previous HGNC Symbols for POLK Gene
Previous GeneCards Identifiers for POLK Gene
External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).[supplied by OMIM, Jan 2010]
GeneCards Summary for POLK Gene
POLK (Polymerase (DNA) Kappa) is a Protein Coding gene. Diseases associated with POLK include prostate cancer and brain compression. Among its related pathways are DNA Double-Strand Break Repair and p53 Pathway (RnD). GO annotations related to this gene include damaged DNA binding and DNA-directed DNA polymerase activity. An important paralog of this gene is POLH.
UniProtKB/Swiss-Prot for POLK Gene
DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3-5 proofreading exonuclease activity. Forms a Schiff base with 5-deoxyribose phosphate at abasic sites, but does not have lyase activity.