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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POLK Gene

protein-coding   GIFtS: 62
GCID: GC05P074843

Polymerase (DNA Directed) Kappa


(Previous symbol: DINB1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Polymerase (DNA Directed) Kappa1 2     DINP2 3
DINB11 2 3 5     EC 2.7.7.73 8
DINB Protein1 3     POLQ2 5
DNA Polymerase Kappa1 2     Polymerase (DNA-Directed) Kappa1

External Ids:    HGNC: 91831   Entrez Gene: 514262   Ensembl: ENSG000001220087   OMIM: 6056505   UniProtKB: Q9UBT63   

Export aliases for POLK gene to outside databases

Previous GC identifers: GC05P073614 GC05P075044 GC05P074846 GC05P074891 GC05P070013


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POLK Gene:
External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells.
Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and
block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity
of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique
DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by
Lone et al., 2007 (PubMed 17317631)).(supplied by OMIM, Jan 2010)

GeneCards Summary for POLK Gene: 
POLK (polymerase (DNA directed) kappa) is a protein-coding gene. Diseases associated with POLK include brain compression, and cholinergic urticaria, and among its related super-pathways are Chks in Checkpoint Regulation. GO annotations related to this gene include damaged DNA binding and DNA-directed DNA polymerase activity. An important paralog of this gene is REV1.

UniProtKB/Swiss-Prot: POLK_HUMAN, Q9UBT6
Function: DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis,
where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context,
it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5'
proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does
not have lyase activity

Gene Wiki entry for POLK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POLK gene promoter:
         AREB6   HEN1   CREB   Sp1   p53   deltaCREB   Cdc5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): POLK promoter sequence
   Search SABiosciences Chromatin IP Primers for POLK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13   Ensembl cytogenetic band:  5q13.3   HGNC cytogenetic band: 5q13

POLK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLK gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P074843:  view genomic region     (about GC identifiers)

Start:
74,807,581 bp from pter      End:
74,896,969 bp from pter
Size:
89,389 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: POLK_HUMAN, Q9UBT6 (See protein sequence)
Recommended Name: DNA polymerase kappa  
Size: 870 amino acids; 98809 Da
Cofactor: Divalent metal cations. Prefers magnesium, but can also use manganese
Subunit: Interacts with REV1 (By similarity). Interacts with PCNA
Subcellular location: Nucleus. Note=Detected throughout the nucleus and at replication foci
6/8 PDB 3D structures from and Proteopedia for POLK (see all 8):
1T94 (3D)        2LSI (3D)        2OH2 (3D)        2W7O (3D)        2W7P (3D)        3IN5 (3D)    
Secondary accessions: B2RBD2 Q86VJ8 Q8IZY0 Q8IZY1 Q8NB30 Q96L01 Q96Q86 Q96Q87 Q9UHC5
Alternative splicing: 4 isoforms:  Q9UBT6-1   Q9UBT6-2   Q9UBT6-3   Q9UBT6-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for POLK: NX_Q9UBT6

Explore proteomics data for POLK at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBT6

  • 3 DME Specific Peptides for POLK (Q9UBT6)
     AAVEMRD  DMDAFYA  LTASAGIAP 

    POLK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    POLK Protein Expression
    REFSEQ proteins: NP_057302.1  
    ENSEMBL proteins: 
     ENSP00000241436   ENSP00000421997   ENSP00000422094   ENSP00000421879   ENSP00000425208  
     ENSP00000424174   ENSP00000423526   ENSP00000420997   ENSP00000425075   ENSP00000424859  
     ENSP00000426853   ENSP00000423532   ENSP00000342256   ENSP00000369848  

    Human Recombinant Protein Products for POLK: 
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    OriGene Protein Over-expression Lysate for POLK
    OriGene MassSpec for POLK 
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    Novus Biologicals POLK Protein
    Novus Biologicals POLK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    POLK for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    POL: DNA polymerases

    5/6 InterPro protein domains (see all 6):
     IPR001126 DNA_repair_prot_UmuC-like
     IPR017963 DNA_repair_prot_UmuC-like_N
     IPR017961 DNA_pol_Y-fam_little_finger
     IPR024728 PolY_HhH_motif
     IPR006642 Znf_Rad18_put

    Graphical View of Domain Structure for InterPro Entry Q9UBT6

    ProtoNet protein and cluster: Q9UBT6

    1 Blocks protein domain: IPB001126 UMUC-like DNA-repair protein

    UniProtKB/Swiss-Prot: POLK_HUMAN, Q9UBT6
    Domain: The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains
    are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster
    around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric
    constraints, with consequently higher rates of misincorporation and low processivity
    Similarity: Belongs to the DNA polymerase type-Y family
    Similarity: Contains 2 UBZ-type zinc fingers
    Similarity: Contains 1 umuC domain


    POLK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: POLK_HUMAN, Q9UBT6
    Function: DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis,
    where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context,
    it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5'
    proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does
    not have lyase activity
    Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
    Biophysicochemical properties: pH dependence: Optimum pH is 6.5-7.5; Temperature dependence: Optimum temperature
    is 37 degrees Celsius;

         Enzyme Number (IUBMB): EC 2.7.7.71 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003684damaged DNA binding IEA--
    GO:0003887DNA-directed DNA polymerase activity IEA--
    GO:0046872metal ion binding IEA--
         
    POLK for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for POLK:
     Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Polk):
     cellular  homeostasis/metabolism  immune system 

    POLK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for POLK: Polktm1Hohm Polktm1.1Rsky

       inGenious Targeting Laboratory - Custom generated mouse model solutions for POLK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POLK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POLK 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POLK 

    miRNA
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    hsa-miR-520f hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-548k hsa-miR-25 hsa-miR-372 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidPOLK 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: POLK (NM_016218)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLK
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                         Customized lentivirus expression plasmids for stable overexpression of POLK 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for POLK About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Chks in Checkpoint Regulation
    DNA Repair Mechanisms0.32
    2Cell Cycle Control of Chromosomal Replication
    Cell Cycle Control of Chromosomal Replication
    3Fanconi anemia pathway
    Fanconi anemia pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POLK
        DNA Repair Mechanisms
    Cell Cycle Control of Chromosomal Replication


    1         Kegg Pathway  (Kegg details for POLK):
        Fanconi anemia pathway


    POLK for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POLK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for POLK (Q9UBT63 ENSP000002414364) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    REV1Q9UBZ93, ENSP000002584284I2D: score=4 STRING: ENSP00000258428
    PCNAP120043, ENSP000003684384I2D: score=2 STRING: ENSP00000368438
    RAD18Q9NS913, ENSP000002649264I2D: score=1 STRING: ENSP00000264926
    XRCC1P188873, ENSP000002628874I2D: score=1 STRING: ENSP00000262887
    RPA1P276943, ENSP000002547194I2D: score=1 STRING: ENSP00000254719
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--
    GO:0006281DNA repair TAS10620008
    GO:0006297nucleotide-excision repair, DNA gap filling IMP--

    POLK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    POLK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POLK

    8 HMDB Compounds for POLK    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Thymidine 5'-triphosphate2'-Deoxythymidine 5'-triphosphate (see all 13)365-08-2--
    dATP2'-Deoxy-5'-ATP (see all 8)1927-31-7--
    dCTP2'-deoxycytidine-5'-triphosphate (see all 4)2056-98-6--
    dGTP2'-Deoxyguanosine 5'-triphosphate (see all 4)2564-35-4--

    3 DrugBank Compounds for POLK    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE-- --target--10592235
    1-[2-DEOXYRIBOFURANOSYL]-2,4-DIFLUORO-5-METHYL-BENZENE-5'MONOPHOSPHATE-- --target--10592235
    2'-deoxy-N-(naphthalen-1-ylmethyl)guanosine 5'-(dihydrogen phosphate)-- --target--10592235

    2 Novoseek inferred chemical compound relationships for POLK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    benzo(a)pyrene 60.2 1 19542228 (1)
    cisplatin 16.9 1 12778700 (1)

    Search CenterWatch for drugs/clinical trials and news about POLK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POLK gene: 
    NM_016218.2  

    Unigene Cluster for POLK:

    Polymerase (DNA directed) kappa
    Hs.135756  [show with all ESTs]
    Unigene Representative Sequence: NM_016218
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000241436(uc003kdw.3 uc003kdx.3 uc003kdy.3 uc003kec.3 uc010izs.3 uc003ked.3 uc003kee.3)
    ENST00000503479 ENST00000510815 ENST00000506928 ENST00000505774 ENST00000514296(uc003kdz.2)
    ENST00000508867(uc003kea.3) ENST00000515295(uc003keb.3) ENST00000514141(uc010izr.3)
    ENST00000511527 ENST00000504026 ENST00000505975 ENST00000508526 ENST00000509126
    ENST00000507073 ENST00000505069 ENST00000502567 ENST00000352007(uc010izq.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate POLK (see all 33):
    hsa-miR-520f hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-548k hsa-miR-25 hsa-miR-372 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidPOLK 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional mRNA sequence: 

    AB027564.1 AB209291.1 AF163570.1 AF194973.1 AF315601.1 AF315602.1 AF318313.1 AK026316.1 
    AK091659.1 AK314610.1 AY769932.1 BC014955.2 BC041798.2 BC050718.1 

    16 DOTS entries:

    DT.86846450  DT.100793764  DT.95126455  DT.120830249  DT.120830320  DT.95277004  DT.95361013  DT.100023167 
    DT.100793763  DT.121633180  DT.40286876  DT.95277007  DT.99941471  DT.75101732  DT.101963549  DT.75124739 

    24/171 AceView cDNA sequences (see all 171):

    AL602753 AF315602 AL597059 BX098742 AI695917 AK091659 CD722627 AL598384 
    AK026316 AI560141 BU175377 AA769578 CF272314 AA907554 AW150566 AA985122 
    AW468655 NM_016218 BC050718 AI080666 BP364061 AI375146 AW162114 AI216215 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for POLK (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d
    SP1:                          -                                                                                                   
    SP2:                                                                                                                              
    SP3:                                                                                -                                             
    SP4:                          -                                               -                                                   
    SP5:                                                                                -     -     -                                 


    ECgene alternative splicing isoforms for POLK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POLK expression in normal human tissues (normalized intensities)      POLK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    POLK Expression
    About this image


    POLK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood Brain Barrier (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Testis (Reproductive System)

    See POLK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POLK

    SOURCE GeneReport for Unigene cluster: Hs.135756

    UniProtKB/Swiss-Prot: POLK_HUMAN, Q9UBT6
    Tissue specificity: Detected at low levels in testis, spleen, prostate and ovary. Detected at very low levels in
    kidney, colon, brain, heart, liver, lung, placenta, pancreas and peripheral blood leukocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for POLK gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Polk1 , 5 polymerase (DNA directed), kappa1, 5 81.73(n)1
    77.88(a)1
      13 (50.56 cM)5
    270151  NM_012048.21  NP_036178.11 
     964806895 
    chicken
    (Gallus gallus)
    Aves POLK1 polymerase (DNA directed) kappa 66.16(n)
    59.01(a)
      374003  NM_204183.1  NP_989514.1 
    lizard
    (Anolis carolinensis)
    Reptilia POLK6
    Uncharacterized protein
    55(a)
    1 ↔ 1
    2(14734021-14765136)
    zebrafish
    (Danio rerio)
    Actinopterygii polk1 polymerase (DNA directed) kappa 58.65(n)
    56.51(a)
      562749  XM_686127.5  XP_691219.4 
    worm
    (Caenorhabditis elegans)
    Secernentea F22B7.63
    polk-11
    mucb3
    Protein POLK-11
    42(a)3
    48.97(n)1
    45.45(a)1
      III(8698443-8700218)3
    1762091  NM_001129220.11  NP_001122692.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes REV16
    Deoxycytidyl transferase; involved in repair of ab...
    9(a)
    1 → many
    XV(981828-984785)
    rice
    (Oryza sativa)
    Liliopsida Os.95492 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 70.58(n)    AK066372.1 


    ENSEMBL Gene Tree for POLK (if available)
    TreeFam Gene Tree for POLK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POLK gene
    REV12  POLH2  POLI2  

    POLK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1659 SNPs in POLK are shown (see all 1659)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1445093381,2
    --74809953(+) GTTTAA/TGATCT 1 -- int10--------
    rs1461520671,2
    --74810057(+) TTTCTC/GTCTAG 1 -- int10--------
    rs1887634671,2
    --74810247(+) AAATTC/GGTCAG 1 -- int10--------
    rs1401506481,2
    C--74810273(+) ATAACA/TTCATA 1 -- int10--------
    rs1816102681,2
    --74810345(+) GGTTCA/GTTTGA 1 -- int10--------
    rs100590221,2
    C,F,H--74810384(+) AGGTAG/AACATT 1 -- int116Minor allele frequency- A:0.15NS EA NA WA 2212
    rs799963111,2
    C,F--74810448(+) TCATCG/CCTAGT 1 -- int12Minor allele frequency- C:0.19CSA WA 120
    rs1872474531,2
    C--74810505(+) ACTTTC/TAATAC 1 -- int10--------
    rs1119982381,2
    F--74810558(+) AATGGC/TACATA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1511769351,2
    C--74810618(+) CCAGAA/GGTTTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for POLK (74807581 - 74896969 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for POLK:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4881CNV Insertion18451855
    dgv6185n71CNV Loss21882294
    nsv882203CNV Loss21882294
    nsv882201CNV Loss21882294
    dgv6184n71CNV Loss21882294
    nsv882202CNV Loss21882294
    nsv882200CNV Loss21882294
    dgv6183n71CNV Loss21882294
    nsv518475CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605650    OMIM disorders: --

    13 diseases for POLK:    About MalaCards
    brain compression    cholinergic urticaria    retinal telangiectasia    vaginal cancer
    vaginitis    urticaria    pneumonia    tuberculosis
    colorectal cancer    retinitis    lung cancer    breast cancer
    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for POLK:
    Brain compression     Cholinergic urticaria

    POLK for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for POLK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 9.87 3 15202001 (2)

    Genetic Association Database (GAD): POLK
    Human Genome Epidemiology (HuGE) Navigator: POLK (10 documents)

    Export disorders for POLK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POLK gene, integrated from 9 sources (see all 78):
    (articles sorted by number of sources associating them with POLK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily. (PubMed id 10518552)1, 2, 3 Gerlach V.L....Friedberg E.C. (1999)
    2. Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides. (PubMed id 12145297)1, 2, 9 Fischhaber P.L....Friedberg E.C. (2002)
    3. Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa. (PubMed id 10887153)1, 3, 9 Ohashi E....Ohmori H. (2000)
    4. Comprehensive screen of genetic variation in DNA repa ir pathway genes and postmenopausal breast cancer risk. (PubMed id 20496165)1, 4 Monsees G.M....Han J. (2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (2009)
    7. Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers. (PubMed id 17494052)1, 4 Michiels S....Benhamou S. (2007)
    8. Crystal structure of the catalytic core of human DNA polymerase kappa. (PubMed id 15296733)1, 2 Uljon S.N....Aggarwal A.K. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. Translesion synthesis past 2'-deoxyxanthosine, a nitric oxide-derived DNA adduct, by mammalian DNA polymerases. (PubMed id 15533436)1, 2 Yasui M.... Shibutani S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51426 HGNC: 9183 AceView: POLK Ensembl:ENSG00000122008 euGenes: HUgn51426
    ECgene: POLK Kegg: 51426 H-InvDB: POLK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POLK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for POLK Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/polk/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for POLK gene:
    Search GeneIP for patents involving POLK

    Licensable Technologies for POLK gene:
    Weizmann Institute:Increasing the efficiency of Chemotherapy by modulating the function of DNA polymerase kappa
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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