Aliases for POLK Gene
External Ids for POLK Gene
Previous HGNC Symbols for POLK Gene
Previous GeneCards Identifiers for POLK Gene
External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).[supplied by OMIM, Jan 2010]
GeneCards Summary for POLK Gene
POLK (Polymerase (DNA Directed) Kappa) is a Protein Coding gene. Diseases associated with POLK include brain compression and testicular lymphoma. Among its related pathways are Chks in Checkpoint Regulation and Homologous DNA Pairing and Strand Exchange. GO annotations related to this gene include damaged DNA binding and DNA-directed DNA polymerase activity. An important paralog of this gene is POLH.
UniProtKB/Swiss-Prot for POLK Gene
DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3-5 proofreading exonuclease activity. Forms a Schiff base with 5-deoxyribose phosphate at abasic sites, but does not have lyase activity.