Aliases for POLI Gene
External Ids for POLI Gene
Previous Symbols for POLI Gene
GeneCards Summary for POLI Gene
POLI (Polymerase (DNA Directed) Iota) is a Protein Coding gene. Diseases associated with POLI include tracheitis. Among its related pathways are Fanconi anemia pathway (KEGG). GO annotations related to this gene include damaged DNA binding and DNA-directed DNA polymerase activity. An important paralog of this gene is POLH.
UniProtKB/Swiss-Prot for POLI Gene
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5-deoxyribose phosphate at abasic sites, but may not have lyase activity.