Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POLI Gene

protein-coding   GIFtS: 56
GCID: GC18P051731

polymerase (DNA directed) iota


(Previous symbols: RAD3OB, RAD30B)
 Explore 27 diseases affiliated with
POLI via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for POLI    

Aliases
for POLI gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Polymerase (DNA Directed) Iota1 2     Eta23
RAD30B1 2 3 5     Polymerase (DNA-Directed), Iota2
RAD3OB1 2     EC 2.7.7.73
RAD30 Homolog B2 3     Eta23
DNA Polymerase Iota2     

External Ids:    HGNC: 91821   Entrez Gene: 112012   Ensembl: ENSG000001017517   OMIM: 6052525   UniProtKB: Q9UNA43   

Export aliases for POLI gene to outside databases

Previous GC identifers: GC18P051966 GC18P050047 GC18P050049 GC18P048651


Summaries
for POLI gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: POLI_HUMAN, Q9UNA4
Function: Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion
synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen
base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits
low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a
role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but
may not have lyase activity

Gene Wiki entry for POLI


Genomic Views
for POLI gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010966.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POLI gene promoter:
         TBP   RFX1   Brachyury   CUTL1   NF-AT   E47   NF-AT2   Hand1   Pax-4a   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: POLI promoter sequence
   Search SABiosciences Chromatin IP Primers for POLI

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1   Ensembl cytogenetic band:  18q21.2   HGNC cytogenetic band: 18q21.1

POLI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLI gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P051731:  view genomic region     (about GC identifiers)

Start:
 51,795,774 bp from pter      End:
 51,847,636 bp from pter
Size:
 51,863 bases      Orientation:
 plus strand

Proteins
for POLI gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: POLI_HUMAN, Q9UNA4 (See protein sequence)
Recommended Name: DNA polymerase iota  
Size: 740 amino acids; 83006 Da
Cofactor: Magnesium
Subunit: Interacts with REV1 (By similarity). Interacts with POLH
Subcellular location: Nucleus. Note=Accumulates at replication forks after DNA damage
Sequence caution: Sequence=AAD50381.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAF63383.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH32662.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAM11872.1; Type=Erroneous gene model
prediction; Sequence=CAB66605.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
6/37 PDB 3D structures from and Proteopedia for POLI (see all 37):
1T3N (3D)        1ZET (3D)        2ALZ (3D)        2DPI (3D)        2DPJ (3D)        2FLL (3D)    
Secondary accessions: Q8N590 Q9H0S1 Q9NYH6

Explore the universe of human proteins at neXtProt for POLI: NX_Q9UNA4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UNA4

    • POLI Protein expression data from MOPED and PaxDb:    About this image 
    POLI Protein Expression
    REFSEQ proteins: NP_009126.2  
    ENSEMBL proteins: 
     ENSP00000462664   ENSP00000385196   ENSP00000464025   ENSP00000462681   ENSP00000463071  
     ENSP00000217800   ENSP00000461983   ENSP00000462146   ENSP00000463971   ENSP00000463065  

    Human Recombinant Protein Products for POLI: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: POLI
    OriGene Protein Over-expression Lysate: POLI
    OriGene Custom Protein Services for POLI 
    GenScript Custom Purified and Recombinant Proteins Services for POLI
    Novus Biologicals POLI Proteins
    Novus Biologicals POLI Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS10458907
    GO:0043231intracellular membrane-bounded organelle IDA--

    POLI for ontologies           About GeneDecksing



    POLI Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 10): POLI
    OriGene Custom Antibody Services for POLI 
    GenScript Superior Antibodies for POLI
    Novus Biologicals POLI Antibodies
    Abcam antibodies for POLI 
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for POLI

    Assay Products for POLI: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for POLI
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for POLI gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    POLI for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001126 DNA_repair_prot_UmuC-like
     IPR017963 DNA_repair_prot_UmuC-like_N
     IPR017961 DNA_pol_Y-fam_little_finger

    Graphical View of Domain Structure for InterPro Entry Q9UNA4

    ProtoNet protein and cluster: Q9UNA4

    1 Blocks protein family: IPB001126 UMUC-like DNA-repair protein

    UniProtKB/Swiss-Prot: POLI_HUMAN, Q9UNA4
    Domain: The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are
    much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an
    active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with
    consequently higher rates of misincorporation and low processivity
    Similarity: Belongs to the DNA polymerase type-Y family
    Similarity: Contains 1 umuC domain


    Function
    for POLI gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: POLI_HUMAN, Q9UNA4
    Function: Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion
    synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen
    base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits
    low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a
    role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but
    may not have lyase activity
    Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

         Enzyme Number (IUBMB): EC 2.7.7.71

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003684damaged DNA binding IEA--
    GO:0003887DNA-directed DNA polymerase activity IEA--
    GO:0005515protein binding IPI19060904
    GO:0046872metal ion binding IEA--
         
    POLI for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for POLI:
     Decreased Wnt reporter activit 

         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Poli):
     immune system  tumorigenesis 

    POLI for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for POLI 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: POLI
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLI
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate POLI (see all 16):
    hsa-miR-3163 hsa-miR-323-3p hsa-miR-562 hsa-miR-1298 hsa-miR-1237 hsa-miR-4255 hsa-miR-431 hsa-miR-1248
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLI (see all 7)
    OriGene shRNA RFP: POLI
    OriGene siRNA: POLI
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLI
    Sirion Biotech Custom design and validation of potent shRNA sequences against POLI 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for POLI
    Sirion Biotech Customized adenovirus for overexpression of POLI 
    Sirion Biotech Customized adenovirus for potent knockdown of POLI

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLI (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLI (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: POLI (NM_007195)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLI 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for POLI
    Search LifeMap BioReagents cell lines for POLI
    Sirion Biotech Customized stable knockdown cell line services for POLI 
    Sirion Biotech Customized inducible knockdown cell line services for POLI
    Sirion Biotech Customized stable overexpressing cell line services for POLI
    Sirion Biotech Customized inducible overexpressing cell line services for POLI

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLI


    Pathways & Interactions
    for POLI gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POLI

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/18 Interacting proteins for POLI (Q9UNA41, 2, 3 ENSP000002178004) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF11Q9Y3C52, 3MINT-60872 I2D: score=3 
    UBCP0CG482, 3, ENSP000003448184MINT-2789491 MINT-2789461 MINT-2789763 MINT-2790263 I2D: score=1 STRING: ENSP00000344818
    XRCC1P188872, 3, ENSP000002628874MINT-7296097 MINT-7296110 I2D: score=1 STRING: ENSP00000262887
    DAZAP2Q150381, 2, 3, ENSP000004049684EBI-741774,EBI-724310 MINT-66469 I2D: score=4 STRING: ENSP00000404968
    CALCOCO2Q131372, 3, ENSP000002589474MINT-67333 I2D: score=5 STRING: ENSP00000258947
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--
    GO:0006281DNA repair IEA--

    POLI for ontologies           About GeneDecksing



    Drugs & Compounds
    for POLI gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    POLI for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POLI

    7 HMDB Compounds for POLI    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Thymidine 5'-triphosphate2'-Deoxythymidine 5'-triphosphate (see all 13)365-08-2--
    dATP2'-Deoxy-5'-ATP (see all 8)1927-31-7--
    dCTP2'-deoxycytidine-5'-triphosphate (see all 4)2056-98-6--
    dGTP2'-Deoxyguanosine 5'-triphosphate (see all 4)2564-35-4--
    7 Novoseek chemical compound relationships for POLI gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dgtp 74.3 1 19179121 (1)
    guanine 60 1 15254543 (1)
    cytosine 58.2 1 15254543 (1)
    thymine 57.1 2 19440206 (1), 15254543 (1)
    adenine 51.5 4 19767609 (2), 17439242 (1), 15254543 (1)
    purine 50.5 1 16615915 (1)
    hydrogen 26.2 1 16914729 (1)

    Search CenterWatch for drugs/clinical trials and news about POLI 

    Transcripts
    for POLI gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for POLI gene: 
    NM_007195.2  

    Unigene Cluster for POLI:

    Polymerase (DNA directed) iota
    Hs.438533  [show with all ESTs]
    Unigene Representative Sequence: NM_007195
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000579534(uc002lfj.4 uc010xds.2 uc002lfk.4 uc010dpg.3)
    ENST00000406285 ENST00000577612 ENST00000579434 ENST00000583136 ENST00000577971(uc002lfl.1)
    ENST00000217800 ENST00000580880 ENST00000580905 ENST00000581950 ENST00000585023
    ENST00000579823 ENST00000577361 ENST00000583576 ENST00000582366 ENST00000577727


    miRNA
    Products:             		 OriGene 3'-UTR Clone: POLI
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLI
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate POLI (see all 16):
    hsa-miR-3163 hsa-miR-323-3p hsa-miR-562 hsa-miR-1298 hsa-miR-1237 hsa-miR-4255 hsa-miR-431 hsa-miR-1248
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLI (see all 7)
    OriGene shRNA RFP: POLI
    OriGene siRNA: POLI
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLI
    Sirion Biotech Custom design and validation of potent shRNA sequences against POLI 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLI (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLI (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: POLI (NM_007195)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLI 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLI
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POLI
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLI
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLI

    Additional cDNA sequence: 

    AF140501.1 AF245438.1 AK093688.1 AK226057.1 AK301578.1 AL136670.1 BC032617.1 BC032662.1 
    BX649100.1 

    10 DOTS entries:

    DT.113140  DT.100640677  DT.100699151  DT.97847906  DT.95366880  DT.121085817  DT.91696950  DT.100737360 
    DT.121085828  DT.91919089 

    24/107 AceView cDNA sequences (see all 107):

    BM450274 BF111492 AW468818 BX477912 BQ438265 CB243862 BX649100 AK093688 
    BM918353 BU688625 BM979833 BM470558 CR607269 BX360120 AA233212 CA418634 
    BX645529 AL136670 CA446505 AA812734 AA156839 BM714817 AA825419 BC032662 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for POLI (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a ·
    SP1:              -     -           -                                                           -     -     -           -     -           -     -               
    SP2:                    -     -     -                                                           -     -     -           -     -           -     -               
    SP3:                                                                                                        -           -     -           -     -               
    SP4:                    -           -                                                                                                                           
    SP5:                                                                                            -     -     -                 -           -     -               

    ExUns: 14b · 14c
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for POLI

    Expression
    for POLI gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POLI expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCAAAAAAA
    POLI Expression
    About this image
    See POLI Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POLI

    SOURCE GeneReport for Unigene cluster: Hs.438533

    UniProtKB/Swiss-Prot: POLI_HUMAN, Q9UNA4
    Tissue specificity: Ubiquitous. Highly expressed in testis

        SABiosciences Custom PCR Arrays for POLI
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLI
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POLI
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLI
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLI
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLI

    Orthologs
    for POLI gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for POLI gene from 5/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia POLI6
    		 --
    		 60(a)
    		 1 ↔ 1
    		 GL343213.1(110536-124686)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.147382 Transcribed sequence with weak similarity to protein refNP_009126.1 (H.sapiens) polymerase (DNA directed) iota; RAD30 (S. cerevisiae) homolog B; polymerase (DNA-directed), iota [Homo sapiens] less 73.54(n)    142033869 
    zebrafish
    (Danio rerio)    		 Actinopterygii poli1 polymerase (DNA directed) iota 54.25(n)
    50(a)    		   550532  NM_001017834.1  NP_001017834.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta DNApol-&igr;3
    DNApol-iota1    		 bypass DNA synthesis iota DNA polymerase3
    CG7602-PA1    		 38(a)3
    44.01(n)1
    34.52(a)1    		   84F53
    409651  NM_141515.21  NP_649772.11 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria dinB6
    		 DNA polymerase IV
    		 27(a)
    		 1 → many
    		 Chromosome(250898-251953)


    ENSEMBL Gene Tree for POLI (if available)
    TreeFam Gene Tree for POLI (if available) 

    Paralogs
    for POLI gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POLI gene
    POLK2  REV12  POLH2  
    1 SIMAP similar gene for POLI using alignment to 9 protein entries:     POLI_HUMAN (see all proteins):
    POLH

    POLI for paralogs           About GeneDecksing



    Genomic Variants
    for POLI gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/637 NCBI SNPs in POLI are shown (see all 637)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1502854451,2
    		--51793940(+) AACAAC/TTATCT 1 -- us2k10--------
    rs768640021,2
    		--51793967(+) TTTCAC/TAAAGA 1 -- us2k10--------
    rs360474271,2
    		C,F--51793968(+) TTCACA/GAAGAT 1 -- us2k18Minor allele frequency- G:0.43NA WA EA 368
    rs1923718231,2
    		--51794006(+) TTATAA/TCCTAG 1 -- us2k10--------
    rs558061451,2
    		--51794013(+) CTAGAT/GAGCAG 1 -- us2k11Minor allele frequency- G:0.01EA 120
    rs781335321,2
    		F--51794210(+) AACCAT/CGCCGC 1 -- us2k13Minor allele frequency- C:0.12WA NA EA 358
    rs1434646781,2
    		--51794235(+) GTAGCA/GGGCCC 1 -- us2k10--------
    rs1461192921,2
    		--51794243(+) CCCGGA/GAGTGC 1 -- us2k10--------
    rs1389588191,2
    		--51794281(+) CCACTA/GCTGGC 1 -- us2k10--------
    rs1492905671,2
    		--51794306(+) ACTGCC/TTCTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for POLI (51795774 - 51847636 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for POLI: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POLI
    DNA2.0 Custom Variant and Variant Library Synthesis for POLI

    Disorders / Diseases
    for POLI gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    POLI for disorders           About GeneDecksing

    OMIM gene information: 605252    OMIM disorders: --

    20/27 diseases for POLI (see all 27):    About MalaCards
    b-cell non-hodgkin lymphoma    non-hodgkin lymphoma    xeroderma pigmentosum    graft versus host disease
    balanoposthitis    hodgkin's lymphoma    mouth disease    burkitt's lymphoma
    chronic lymphocytic leukemia    lymphocytic leukemia    cervical carcinoma    cervicitis
    meningioma    influenza    leukemia    lung cancer
    breast cancer    adenoma    pneumonia    esophagitis

    3 diseases from the University of Copenhagen DISEASES database for POLI:
    Balanoposthitis     Tracheitis     Influenza

    3 Novoseek disease relationships for POLI gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xeroderma pigmentosum 69.1 1 17409408 (1)
    burkitt lymphoma 29.1 1 12410315 (1)
    tumors 0 2 17056006 (2)

    Genetic Association Database (GAD): POLI
    Human Genome Epidemiology (HuGE) Navigator: POLI (45 documents)

    Export disorders for POLI gene to outside databases

    Publications
    for POLI gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POLI gene, integrated from 9 sources (see all 111):
    (articles sorted by number of sources associating them with POLI)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Increased catalytic activity and altered fidelity of human DNA polymerase iota in the presence of manganese. (PubMed id 17609217)1, 3, 9 Frank E.G. and Woodgate R. (2007)
    2. Replication by human DNA polymerase-iota occurs by Hoogsteen base- pairing. (PubMed id 15254543)1, 2, 9 Nair D.T.... Aggarwal A.K. (2004)
    3. Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa. (PubMed id 15199127)1, 2, 9 Washington M.T.... Prakash L. (2004)
    4. Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota. (PubMed id 12410315)1, 2, 9 Faili A....Weill J.-C. (2002)
    5. 5'-deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro. (PubMed id 11251121)1, 2, 9 Bebenek K.... Kunkel T.A. (2001)
    6. Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota. (PubMed id 11013228)1, 2, 9 Tissier A....Woodgate R. (2000)
    7. Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta. (PubMed id 10458907)1, 2, 9 McDonald J.P.... Woodgate R. (1999)
    8. Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells. (PubMed id 12606586)1, 2, 9 Kannouche P.L.... Lehmann A.R. (2003)
    9. Altered nucleotide misinsertion fidelity associated with poliota- dependent replication at the end of a DNA template. (PubMed id 11387224)1, 2, 9 Frank E.G.... Woodgate R. (2001)
    10. Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. (PubMed id 16195237)1, 4 Zienolddiny S....Haugen A. (2006)

    External Searches for POLI gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing POLI gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11201 HGNC: 9182 AceView: POLI Ensembl:ENSG00000101751 euGenes: HUgn11201
    ECgene: POLI H-InvDB: POLI

    Other Databases showing POLI gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing POLI gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POLI Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for POLI Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/poli/

    Intellectual Property
    for POLI gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for POLI gene:
    Search GeneIP for patents involving POLI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for POLI gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for POLI   OriGene shRNA RFP for POLI  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLI   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLI  
     OriGene Protein Over-expression Lysate for POLI   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for POLI   OriGene 3'-UTR Clone for POLI  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLI   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLI  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for POLI   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for POLI   OriGene Custom Protein Services for POLI  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POLI
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POLI
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLI
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLI
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLI
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLI
     GenScript Custom Purified and Recombinant Proteins Services for POLI GenScript cDNA clones with any tag delivered in your preferred vector for POLI
     GenScript Custom Assay Services for POLI GenScript Superior Antibodies for POLI
     GenScript Custom overexpressing Cell Line Services for POLI CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in POLI promoter
     Search Chromatin IP Primers for POLI
     RT2 qPCR Primer Assay in human, mouse, rat POLI
     GNC Network for POLI
     SABiosciences Custom PCR Arrays for POLI
     Search Tocris compounds for POLI
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     POLI antibodies
     POLI proteins
     POLI lysates
     Antibodies for POLI
     See all of Abcam's Antibodies, Kits and Proteins for POLI
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for POLI
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLI
     Browse SwitchGear 3'UTR luciferase reporter plasmids for POLI
     SwitchGear Promoter luciferase reporter plasmids for POLI
     ThermoFisher Antibodies for POLI
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLI
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for POLI
    Sirion Biotech Customized:
     stable knockdown cell line services for POLI
     inducible knockdown cell line services for POLI
     design and validation of potent shRNA sequences against POLI
     adenovirus for potent knockdown of POLI
     adenovirus for overexpression of POLI
     stable overexpressing cell line services for POLI
     inducible overexpressing cell line services for POLI
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      POLI gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4