Free for academic non-profit institutions. Other users need a Commercial license

Aliases for POLH Gene

Aliases for POLH Gene

  • DNA Polymerase Eta 2 3 5
  • Xeroderma Pigmentosum Variant Type Protein 3 4
  • Polymerase (DNA Directed), Eta 2 3
  • Polymerase (DNA) Eta 2 3
  • RAD30 Homolog A 3 4
  • RAD30A 3 4
  • RAD30 3 4
  • XPV 3 4
  • EC 2.7.7.7 4
  • XP-V 3

External Ids for POLH Gene

Previous GeneCards Identifiers for POLH Gene

  • GC06P043546
  • GC06P043590
  • GC06P043651
  • GC06P043264
  • GC06P043543

Summaries for POLH Gene

Entrez Gene Summary for POLH Gene

  • This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

GeneCards Summary for POLH Gene

POLH (DNA Polymerase Eta) is a Protein Coding gene. Diseases associated with POLH include Xeroderma Pigmentosum, Variant Type and Polh-Related Xeroderma Pigmentosum. Among its related pathways are Homologous DNA Pairing and Strand Exchange and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template. GO annotations related to this gene include damaged DNA binding and DNA-directed DNA polymerase activity. An important paralog of this gene is POLI.

UniProtKB/Swiss-Prot for POLH Gene

  • DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3 guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5-deoxyribose phosphate (5-dRP) residue. This covalent trapping of the enzyme by the 5-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586).

Gene Wiki entry for POLH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLH Gene

Genomics for POLH Gene

Regulatory Elements for POLH Gene

Enhancers for POLH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F043119 1.4 Ensembl ENCODE 77.8 -452.8 -452752 8.7 PKNOX1 MLX ZFP64 ARID4B FEZF1 DMAP1 FOS ZNF263 SP3 SP5 CUL7 POLH RPS2P29 GLTSCR1L RPL34P14 ENSG00000271970 UBR2 RPL24P4 PEX6 ENSG00000272223
GH06F043087 1.4 Ensembl ENCODE 69.7 -484.9 -484941 7.3 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 POLH RPS2P29 CUL7 GLTSCR1L RPL34P14 ENSG00000271970 PEX6 RPL24P4 UBR2 ENSG00000272223
GH06F043141 1.4 Ensembl ENCODE 69.7 -432.7 -432679 3.6 HDGF PKNOX1 ZFP64 ARID4B SIN3A ZNF2 ZNF302 ZNF143 ZNF263 SP5 CUL7 POLH RPS2P29 RPL34P14 ENSG00000271970 GLTSCR1L RPL24P4 DNPH1 PEX6 UBR2
GH06F044245 1.2 ENCODE 81.1 +671.4 671407 5.0 CREB3L1 YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC TBX21 POLH RPS2P29 LOC101929726 CDC5L RPL29P16 ENSG00000223469 RPS2P28 ENSG00000271970 YIPF3 AARS2
GH06F044056 1.9 FANTOM5 Ensembl ENCODE 38 +486.6 486626 13.1 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A YY1 SLC30A9 CBX5 POLH NFKBIE AARS2 RPS2P29 MRPL14 TMEM63B CUL9 ENSG00000271754 VEGFA SLC35B2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLH on UCSC Golden Path with GeneCards custom track

Promoters for POLH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001217126 59 3601 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1

Genomic Location for POLH Gene

Chromosome:
6
Start:
43,576,141 bp from pter
End:
43,620,523 bp from pter
Size:
44,383 bases
Orientation:
Plus strand

Genomic View for POLH Gene

Genes around POLH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLH Gene

Proteins for POLH Gene

  • Protein details for POLH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y253-POLH_HUMAN
    Recommended name:
    DNA polymerase eta
    Protein Accession:
    Q9Y253
    Secondary Accessions:
    • Q7L8E3
    • Q96BC4
    • Q9BX13

    Protein attributes for POLH Gene

    Size:
    713 amino acids
    Molecular mass:
    78413 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with REV1 (By similarity). Interacts with monoubiquitinated PCNA, but not unmodified PCNA (PubMed:15149598). Interacts with POLI; this interaction targets POLI to the replication machinery (PubMed:12606586). Interacts with PALB2 and BRCA2; the interactions are direct and are required to sustain the recruitment of POLH at blocked replication forks and to stimulate POLH-dependent DNA synthesis on D loop substrates (PubMed:24485656).

    Three dimensional structures from OCA and Proteopedia for POLH Gene

    Alternative splice isoforms for POLH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLH Gene

Post-translational modifications for POLH Gene

  • Monoubiquitinated by RCHY1/PIRH2; ubiquitination inhibits the ability of PolH to interact with PCNA and to bypass UV-induced lesions.
  • Ubiquitination at Lys 682, Lys 686, Lys 694, and Lys 709
  • Modification sites at PhosphoSitePlus

Other Protein References for POLH Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for POLH (POLH)
  • Santa Cruz Biotechnology (SCBT) Antibodies for POLH

No data available for DME Specific Peptides for POLH Gene

Domains & Families for POLH Gene

Gene Families for POLH Gene

Protein Domains for POLH Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y253

UniProtKB/Swiss-Prot:

POLH_HUMAN :
  • The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity.
  • Belongs to the DNA polymerase type-Y family.
Domain:
  • The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity.
  • Contains 1 umuC domain.
Family:
  • Belongs to the DNA polymerase type-Y family.
genes like me logo Genes that share domains with POLH: view

Function for POLH Gene

Molecular function for POLH Gene

GENATLAS Biochemistry:
polymerase eta,yeast (S cerevisia) RAD30 homolog with a thymine dimer by pass DNA polymerase activity,error free replicator (? relationship with ERCC6)
UniProtKB/Swiss-Prot CatalyticActivity:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
UniProtKB/Swiss-Prot Function:
DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3 guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5-deoxyribose phosphate (5-dRP) residue. This covalent trapping of the enzyme by the 5-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586).

Enzyme Numbers (IUBMB) for POLH Gene

Gene Ontology (GO) - Molecular Function for POLH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003684 damaged DNA binding IEA,TAS --
GO:0003887 DNA-directed DNA polymerase activity TAS --
GO:0005515 protein binding IPI 16763556
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with POLH: view
genes like me logo Genes that share phenotypes with POLH: view

Human Phenotype Ontology for POLH Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for POLH Gene

MGI Knock Outs for POLH:

Animal Model Products

  • Taconic Biosciences Mouse Models for POLH

miRNA for POLH Gene

miRTarBase miRNAs that target POLH

Inhibitory RNA Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for POLH Gene

Localization for POLH Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLH Gene

Nucleus. Note=Accumulates at replication forks after DNA damage (PubMed:12606586). After UV irradiation, recruited to DNA damage sites within 1 hour, to a maximum of about 80%; this recruitment may not be not restricted to cells active in DNA replication (PubMed:22801543). {ECO:0000269 PubMed:12606586, ECO:0000269 PubMed:22801543}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLH gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1

Gene Ontology (GO) - Cellular Components for POLH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with POLH: view

Pathways & Interactions for POLH Gene

genes like me logo Genes that share pathways with POLH: view

SIGNOR curated interactions for POLH Gene

Is activated by:

Gene Ontology (GO) - Biological Process for POLH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000731 DNA synthesis involved in DNA repair IDA 17563354
GO:0006260 DNA replication IEA --
GO:0006281 DNA repair IEA,TAS 10871396
GO:0006282 regulation of DNA repair TAS 10398605
GO:0006290 pyrimidine dimer repair IEA --
genes like me logo Genes that share ontologies with POLH: view

Drugs & Compounds for POLH Gene

(9) Drugs for POLH Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Manganese Approved Nutra 34
dctp Experimental Pharma 0
Deoxyadenosine triphosphate Experimental Pharma 0
dgtp Experimental Pharma 0

(2) Additional Compounds for POLH Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • 5-Methyl-dUTP
  • Deoxy-TTP
365-08-2
genes like me logo Genes that share compounds with POLH: view

Transcripts for POLH Gene

Unigene Clusters for POLH Gene

Polymerase (DNA directed), eta:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLH Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3:
SP4: - - - - - -
SP5: - - - - -
SP6: - -

Relevant External Links for POLH Gene

GeneLoc Exon Structure for
POLH
ECgene alternative splicing isoforms for
POLH

Expression for POLH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POLH Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POLH Gene



NURSA nuclear receptor signaling pathways regulating expression of POLH Gene:

POLH

SOURCE GeneReport for Unigene cluster for POLH Gene:

Hs.655467
genes like me logo Genes that share expression patterns with POLH: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for POLH Gene

Orthologs for POLH Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POLH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLH 34 35
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia POLH 34 35
  • 89.37 (n)
cow
(Bos Taurus)
Mammalia POLH 34 35
  • 87.29 (n)
mouse
(Mus musculus)
Mammalia Polh 34 16 35
  • 83.77 (n)
rat
(Rattus norvegicus)
Mammalia Polh 34
  • 82.34 (n)
oppossum
(Monodelphis domestica)
Mammalia POLH 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLH 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves POLH 34 35
  • 60.67 (n)
lizard
(Anolis carolinensis)
Reptilia POLH 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polh 34
  • 66.8 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16068 34
zebrafish
(Danio rerio)
Actinopterygii polh 34 35
  • 58.11 (n)
wufc50a12 34
fruit fly
(Drosophila melanogaster)
Insecta DNApol-eegr 36
  • 39 (a)
DNApol-eta 35
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea polh-1 34 35
  • 48.26 (n)
F53A3.2 36
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REV1 35
  • 9 (a)
OneToMany
RAD30 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.951 34
Species where no ortholog for POLH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLH Gene

ENSEMBL:
Gene Tree for POLH (if available)
TreeFam:
Gene Tree for POLH (if available)

Paralogs for POLH Gene

Paralogs for POLH Gene

(1) SIMAP similar genes for POLH Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for POLH Gene

genes like me logo Genes that share paralogs with POLH: view

Variants for POLH Gene

Sequence variations from dbSNP and Humsavar for POLH Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs121908565 Xeroderma pigmentosum variant type (XPV) [MIM:278750], Pathogenic 43,614,181(+) CTCTA(A/C)AGCAA reference, missense, utr-variant-3-prime
rs199562456 Xeroderma pigmentosum variant type (XPV) [MIM:278750] 43,614,489(+) CCTGC(A/G)CTAAT reference, missense, utr-variant-3-prime
rs367709714 A breast cancer sample 43,587,457(+) CCAAG(A/G)CCCTA intron-variant, reference, missense
rs56307355 Xeroderma pigmentosum variant type (XPV) [MIM:278750], Pathogenic 43,614,018(+) AGCAG(A/G)AAAGT reference, missense, utr-variant-3-prime
rs756931657 Xeroderma pigmentosum variant type (XPV) [MIM:278750] 43,587,277(+) GTACC(C/G)GGAAG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for POLH Gene

Variant ID Type Subtype PubMed ID
nsv5281 CNV deletion 18451855

Variation tolerance for POLH Gene

Residual Variation Intolerance Score: 79.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.81; 79.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLH Gene

Human Gene Mutation Database (HGMD)
POLH
SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLH Gene

Disorders for POLH Gene

MalaCards: The human disease database

(3) MalaCards diseases for POLH Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search POLH in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

POLH_HUMAN
  • Xeroderma pigmentosum variant type (XPV) [MIM:278750]: An autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. XPV shows normal nucleotide excision repair, but an exaggerated delay in recovery of replicative DNA synthesis. Most patients with the variant type of xeroderma pigmentosum do not develop clinical symptoms and skin neoplasias until a later age. Clinical manifestations are limited to photo-induced deterioration of the skin and eyes. {ECO:0000269 PubMed:10385124, ECO:0000269 PubMed:10398605, ECO:0000269 PubMed:11032022, ECO:0000269 PubMed:11121129, ECO:0000269 PubMed:11773631, ECO:0000269 PubMed:24130121}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for POLH

Genetic Association Database (GAD)
POLH
Human Genome Epidemiology (HuGE) Navigator
POLH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLH
genes like me logo Genes that share disorders with POLH: view

No data available for Genatlas for POLH Gene

Publications for POLH Gene

  1. The XPV (Xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. (PMID: 10385124) Masutani C. … Hanaoka F. (Nature 1999) 2 3 4 22 64
  2. hRAD30 mutations in the variant form of xeroderma pigmentosum. (PMID: 10398605) Johnson R.E. … Prakash L. (Science 1999) 2 3 4 22 64
  3. Variants of the xeroderma pigmentosum variant gene (POLH) are associated with melanoma risk. (PMID: 19477635) Di Lucca J. … Soufir N. (Eur. J. Cancer 2009) 3 22 46 64
  4. DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. (PMID: 11376341) Zeng X. … Gearhart P.J. (Nat. Immunol. 2001) 3 4 22 64
  5. Human Pol IP purified with accessory subunits is active in translesion DNA synthesis and complements Pol I^ in cisplatin bypass. (PMID: 24449906) Lee Y.S. … Yang W. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 4 64

Products for POLH Gene

Sources for POLH Gene

Content
Loading form....