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Aliases for POLE3 Gene

Aliases for POLE3 Gene

  • Polymerase (DNA) Epsilon 3, Accessory Subunit 2 3
  • Polymerase (DNA Directed), Epsilon 3, Accessory Subunit 3 5
  • Polymerase (DNA Directed), Epsilon 3 (P17 Subunit) 2 3
  • Chromatin Accessibility Complex 17 KDa Protein 3 4
  • DNA Polymerase Epsilon P17 Subunit 2 3
  • DNA Polymerase Epsilon Subunit P17 3 4
  • Arsenic Transactivated Protein 2 3
  • Arsenic-Transactivated Protein 3 4
  • Histone Fold Protein CHRAC17 2 3
  • DNA Polymerase II Subunit 3 3 4
  • EC 2.7.7.7 4 63
  • HuCHRAC17 3 4
  • CHRAC-17 3 4
  • CHRAC17 3 4
  • AsTP 3 4
  • Chromatin Accessibility Complex 17 2
  • CHARAC17 3
  • YBL1 3
  • P17 3

External Ids for POLE3 Gene

Previous GeneCards Identifiers for POLE3 Gene

  • GC09M106967
  • GC09M107901
  • GC09M109623
  • GC09M111545
  • GC09M113249
  • GC09M115209
  • GC09M116169
  • GC09M085777

Summaries for POLE3 Gene

Entrez Gene Summary for POLE3 Gene

  • POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]

GeneCards Summary for POLE3 Gene

POLE3 (Polymerase (DNA) Epsilon 3, Accessory Subunit) is a Protein Coding gene. Diseases associated with POLE3 include descending colon cancer and human immunodeficiency virus infectious disease. Among its related pathways are Metabolism and Pyrimidine metabolism (KEGG). GO annotations related to this gene include sequence-specific DNA binding and DNA-directed DNA polymerase activity. An important paralog of this gene is NFYB.

UniProtKB/Swiss-Prot for POLE3 Gene

  • Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.

Gene Wiki entry for POLE3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLE3 Gene

Genomics for POLE3 Gene

Regulatory Elements for POLE3 Gene

Promoters for POLE3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POLE3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the POLE3 gene promoter:

Genomic Location for POLE3 Gene

Chromosome:
9
Start:
113,407,235 bp from pter
End:
113,410,749 bp from pter
Size:
3,515 bases
Orientation:
Minus strand

Genomic View for POLE3 Gene

Genes around POLE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLE3 Gene

Proteins for POLE3 Gene

  • Protein details for POLE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRF9-DPOE3_HUMAN
    Recommended name:
    DNA polymerase epsilon subunit 3
    Protein Accession:
    Q9NRF9
    Secondary Accessions:
    • Q5W0U1
    • Q8N758
    • Q8NCE5
    • Q9NR32

    Protein attributes for POLE3 Gene

    Size:
    147 amino acids
    Molecular mass:
    16860 Da
    Quaternary structure:
    • Component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4. Interaction with POLE4 is a prerequisite for further binding with POLE and POLE2. Interacts with CHRAC1. Together with CHRAC1, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC.

neXtProt entry for POLE3 Gene

Proteomics data for POLE3 Gene at MOPED

Selected DME Specific Peptides for POLE3 Gene

Post-translational modifications for POLE3 Gene

  • Ubiquitination at Lys 31, Lys 62, and Lys 86
  • Modification sites at PhosphoSitePlus

Other Protein References for POLE3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for POLE3 Gene

Gene Families for POLE3 Gene

Protein Domains for POLE3 Gene

Suggested Antigen Peptide Sequences for POLE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with POLE3: view

No data available for UniProtKB/Swiss-Prot for POLE3 Gene

Function for POLE3 Gene

Molecular function for POLE3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
UniProtKB/Swiss-Prot Function:
Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.

Enzyme Numbers (IUBMB) for POLE3 Gene

Gene Ontology (GO) - Molecular Function for POLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with POLE3: view
genes like me logo Genes that share phenotypes with POLE3: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLE3 Gene

Localization for POLE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLE3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLE3 Gene COMPARTMENTS Subcellular localization image for POLE3 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for POLE3 Gene

Pathways & Interactions for POLE3 Gene

genes like me logo Genes that share pathways with POLE3: view

Pathways by source for POLE3 Gene

Gene Ontology (GO) - Biological Process for POLE3 Gene

None

No data available for SIGNOR curated interactions for POLE3 Gene

Drugs & Compounds for POLE3 Gene

(6) Drugs for POLE3 Gene - From: HMDB, DrugBank, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cladribine Approved, Investigational Pharma Target, inhibitor Apoptosis inducer in CLL cells 67
Clofarabine Approved, Investigational Pharma Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase 153
dctp Experimental Pharma 0
Deoxyadenosine triphosphate Experimental Pharma 0
dgtp Experimental Pharma 0

(2) Additional Compounds for POLE3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • 5-Methyl-dUTP
  • Deoxy-TTP
365-08-2

(1) ApexBio Compounds for POLE3 Gene

Compound Action Cas Number
Clofarabine Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase 123318-82-1
genes like me logo Genes that share compounds with POLE3: view

Transcripts for POLE3 Gene

Unigene Clusters for POLE3 Gene

Polymerase (DNA directed), epsilon 3, accessory subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLE3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: -
SP2: - -
SP3:
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for POLE3 Gene

GeneLoc Exon Structure for
POLE3
ECgene alternative splicing isoforms for
POLE3

Expression for POLE3 Gene

mRNA expression in normal human tissues for POLE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLE3 Gene

This gene is overexpressed in Bone (23.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLE3 Gene



SOURCE GeneReport for Unigene cluster for POLE3 Gene Hs.108112

mRNA Expression by UniProt/SwissProt for POLE3 Gene

Q9NRF9-DPOE3_HUMAN
Tissue specificity: Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with POLE3: view

Protein tissue co-expression partners for POLE3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for POLE3 Gene

Orthologs for POLE3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POLE3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POLE3 35
  • 93.88 (n)
  • 100 (a)
POLE3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLE3 35
  • 91.38 (n)
  • 98.64 (a)
POLE3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pole3 35
  • 91.53 (n)
  • 99.18 (a)
Pole3 16
Gm21827 36
  • 77 (a)
OneToMany
Pole3 36
  • 94 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia POLE3 35
  • 100 (n)
  • 100 (a)
POLE3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pole3 35
  • 90.98 (n)
  • 99.18 (a)
oppossum
(Monodelphis domestica)
Mammalia POLE3 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves POLE3 35
  • 77.87 (n)
  • 92.44 (a)
POLE3 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pole3 35
  • 77.51 (n)
  • 89.43 (a)
Str.10053 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.32726 35
zebrafish
(Danio rerio)
Actinopterygii pole3 35
  • 74.25 (n)
  • 82.11 (a)
zgc73351 35
pole3 36
  • 75 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9305 35
fruit fly
(Drosophila melanogaster)
Insecta Chrac-14 35
  • 58.5 (n)
  • 53.92 (a)
Chrac-14 36
  • 47 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAP3 36
  • 20 (a)
OneToMany
Species with no ortholog for POLE3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POLE3 Gene

ENSEMBL:
Gene Tree for POLE3 (if available)
TreeFam:
Gene Tree for POLE3 (if available)

Paralogs for POLE3 Gene

Paralogs for POLE3 Gene

(1) SIMAP similar genes for POLE3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with POLE3: view

Variants for POLE3 Gene

Sequence variations from dbSNP and Humsavar for POLE3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_023464 -
VAR_023465 -
VAR_057527 -
rs14419 -- 113,408,279(+) AGAAC(A/G)GATTT nc-transcript-variant, utr-variant-3-prime
rs2792813 -- 113,407,435(-) AATAT(C/G)TCTGT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for POLE3 Gene

Variant ID Type Subtype PubMed ID
nsv893744 CNV Gain 21882294

Variation tolerance for POLE3 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLE3 Gene

HapMap Linkage Disequilibrium report
POLE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLE3 Gene

Disorders for POLE3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for POLE3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
descending colon cancer
  • ca descending colon
human immunodeficiency virus infectious disease
syphilitic meningitis
  • syphilitic aseptic meningitis
primary syphilis
  • early symptomatic syphilis
latent syphilis
  • syphilis, latent
- elite association - COSMIC cancer census association via MalaCards
Search POLE3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for POLE3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLE3
genes like me logo Genes that share disorders with POLE3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLE3 Gene

Publications for POLE3 Gene

  1. HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins. (PMID: 10880450) Poot R.A. … Varga-Weisz P.D. (EMBO J. 2000) 2 3 4 67
  2. Mechanisms of anti-cancer action and pharmacology of clofarabine. (PMID: 19576186) Zhenchuk A. … Albertioni F. (Biochem. Pharmacol. 2009) 25 26
  3. The histone-fold protein complex CHRAC-15/17 enhances nucleosome sliding and assembly mediated by ACF. (PMID: 14759371) Kukimoto I. … Varga-Weisz P.D. (Mol. Cell 2004) 3 23
  4. Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. (PMID: 10801849) Li Y. … Linn S. (J. Biol. Chem. 2000) 2 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for POLE3 Gene

Sources for POLE3 Gene

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