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Aliases for POLE2 Gene

Aliases for POLE2 Gene

  • Polymerase (DNA Directed), Epsilon 2, Accessory Subunit 2 3
  • DNA Polymerase Epsilon Subunit B 2 3 4
  • DPE2 3 4 6
  • Polymerase (DNA Directed), Epsilon 2 (P59 Subunit) 2 3
  • DNA Polymerase II Subunit 2 3 4
  • EC 2.7.7.7 4 63
  • DNA Polymerase Epsilon Subunit 2 3

External Ids for POLE2 Gene

Previous GeneCards Identifiers for POLE2 Gene

  • GC14M047432
  • GC14M043906
  • GC14M048100
  • GC14M049180
  • GC14M050110
  • GC14M030227

Summaries for POLE2 Gene

GeneCards Summary for POLE2 Gene

POLE2 (Polymerase (DNA Directed), Epsilon 2, Accessory Subunit) is a Protein Coding gene. Among its related pathways are DNA replication initiation and DNA replication initiation. GO annotations related to this gene include DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot for POLE2 Gene

  • Participates in DNA repair and in chromosomal DNA replication

Gene Wiki entry for POLE2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLE2 Gene

Genomics for POLE2 Gene

Regulatory Elements for POLE2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for POLE2 Gene

Start:
49,643,552 bp from pter
End:
49,688,422 bp from pter
Size:
44,871 bases
Orientation:
Minus strand

Genomic View for POLE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POLE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLE2 Gene

Proteins for POLE2 Gene

  • Protein details for POLE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56282-DPOE2_HUMAN
    Recommended name:
    DNA polymerase epsilon subunit 2
    Protein Accession:
    P56282
    Secondary Accessions:
    • A0AV55
    • A4FU92
    • A4LBB7
    • A6NH58
    • B4DDE6
    • O43560

    Protein attributes for POLE2 Gene

    Size:
    527 amino acids
    Molecular mass:
    59537 Da
    Quaternary structure:
    • Component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4.
    Miscellaneous:
    • In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis

    Three dimensional structures from OCA and Proteopedia for POLE2 Gene

    Alternative splice isoforms for POLE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLE2 Gene

Proteomics data for POLE2 Gene at MOPED

Selected DME Specific Peptides for POLE2 Gene

Post-translational modifications for POLE2 Gene

  • Ubiquitination at Lys270 and Lys523
  • Modification sites at PhosphoSitePlus

Other Protein References for POLE2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for POLE2 Gene

Gene Families for POLE2 Gene

Protein Domains for POLE2 Gene

Suggested Antigen Peptide Sequences for POLE2 Gene

Graphical View of Domain Structure for InterPro Entry

P56282

UniProtKB/Swiss-Prot:

DPOE2_HUMAN :
  • Belongs to the DNA polymerase epsilon subunit B family.
Family:
  • Belongs to the DNA polymerase epsilon subunit B family.
genes like me logo Genes that share domains with POLE2: view

Function for POLE2 Gene

Molecular function for POLE2 Gene

GENATLAS Biochemistry:
polymerase (DNA directed) epsilon 2,59kDa,potential adaptor between the catalytic subunit and other accessory proteins
UniProtKB/Swiss-Prot CatalyticActivity:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
UniProtKB/Swiss-Prot Function:
Participates in DNA repair and in chromosomal DNA replication

Enzyme Numbers (IUBMB) for POLE2 Gene

Gene Ontology (GO) - Molecular Function for POLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003887 DNA-directed DNA polymerase activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with POLE2: view

Phenotypes for POLE2 Gene

GenomeRNAi human phenotypes for POLE2:
genes like me logo Genes that share phenotypes with POLE2: view

Animal Model Products

miRNA for POLE2 Gene

miRTarBase miRNAs that target POLE2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POLE2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for POLE2 Gene

Localization for POLE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLE2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLE2 Gene COMPARTMENTS Subcellular localization image for POLE2 gene
Compartment Confidence
nucleus 5
mitochondrion 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for POLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0008622 epsilon DNA polymerase complex IDA 10801849
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with POLE2: view

Pathways for POLE2 Gene

genes like me logo Genes that share pathways with POLE2: view

Gene Ontology (GO) - Biological Process for POLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0000722 telomere maintenance via recombination TAS --
GO:0000723 telomere maintenance TAS --
GO:0006260 DNA replication TAS 9405441
genes like me logo Genes that share ontologies with POLE2: view

Drugs for POLE2 Gene

(1) Drugbank Compounds for POLE2 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Cladribine
  • (2R,3S,5R)-5-(6-amino-2-Chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
4291-63-8 20279 Target inhibitor approved, investigational

(1) ApexBio Compounds for POLE2 Gene

Compound Action Cas Number
Cytarabine [147-94-4]

(7) HMDB Compounds for POLE2 Gene

Compound Synonyms Cas Number PubMed IDs
Cladribine
  • 2-CdA
4291-63-8
dCTP
  • 2'-Deoxycytidine-5'-triphosphate
2056-98-6
Deoxyadenosine triphosphate
  • 2'-Deoxy-5'-ATP
1927-31-7
dGTP
  • Deoxyguanosine 5'-triphosphate
2564-35-4
Phosphoric acid
  • Acide phosphorique (FRENCH)
7664-38-2
genes like me logo Genes that share compounds with POLE2: view

Transcripts for POLE2 Gene

Unigene Clusters for POLE2 Gene

Polymerase (DNA directed), epsilon 2, accessory subunit:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POLE2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLE2 Gene

No ASD Table

Relevant External Links for POLE2 Gene

GeneLoc Exon Structure for
POLE2
ECgene alternative splicing isoforms for
POLE2

Expression for POLE2 Gene

mRNA expression in normal human tissues for POLE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for POLE2 Gene

This gene is overexpressed in Heart (56.1) and Fetal ovary (12.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLE2 Gene

SOURCE GeneReport for Unigene cluster for POLE2 Gene Hs.162777

genes like me logo Genes that share expressions with POLE2: view

Expression partners for POLE2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLE2 Gene

Orthologs for POLE2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLE2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POLE2 35
  • 92.73 (n)
  • 94.88 (a)
POLE2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLE2 35
  • 91.52 (n)
  • 93.55 (a)
mouse
(Mus musculus)
Mammalia Pole2 35
  • 86.27 (n)
  • 90.13 (a)
Pole2 16
Pole2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLE2 35
  • 99.56 (n)
  • 99.05 (a)
POLE2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pole2 35
  • 86.53 (n)
  • 90.89 (a)
oppossum
(Monodelphis domestica)
Mammalia POLE2 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLE2 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves POLE2 35
  • 78.05 (n)
  • 82.16 (a)
POLE2 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLE2 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pole2 35
  • 76.09 (n)
  • 81.02 (a)
Str.3481 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1015 35
zebrafish
(Danio rerio)
Actinopterygii pole2 35
  • 65.4 (n)
  • 73.24 (a)
pole2 36
  • 74 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6430 35
fruit fly
(Drosophila melanogaster)
Insecta CG10489 37
  • 44 (a)
Pole2 35
  • 49.12 (n)
  • 42.86 (a)
Pole2 36
  • 41 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004614 35
  • 50.23 (n)
  • 42.07 (a)
worm
(Caenorhabditis elegans)
Secernentea F08B4.5 37
  • 30 (a)
pole-2 35
  • 47.19 (n)
  • 31.73 (a)
pole-2 36
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DPB2 36
  • 21 (a)
OneToOne
DPB2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons DPB2 35
  • 48.31 (n)
  • 39.53 (a)
rice
(Oryza sativa)
Liliopsida Os05g0160800 35
  • 49.77 (n)
  • 40.06 (a)
Species with no ortholog for POLE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLE2 Gene

ENSEMBL:
Gene Tree for POLE2 (if available)
TreeFam:
Gene Tree for POLE2 (if available)

Paralogs for POLE2 Gene

Pseudogenes.org Pseudogenes for POLE2 Gene

genes like me logo Genes that share paralogs with POLE2: view

No data available for Paralogs for POLE2 Gene

Variants for POLE2 Gene

Sequence variations from dbSNP and Humsavar for POLE2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2354454 -- 49,643,128(+) tttat(G/T)tcttt downstream-variant-500B
rs2883443 -- 49,643,184(+) aatgg(C/G)acaat downstream-variant-500B
rs3007038 -- 49,656,281(+) acccc(A/G)ggggg intron-variant
rs3212323 -- 49,654,140(-) GTTCA(A/G)ATTTT intron-variant
rs3218790 -- 49,650,435(-) TTGTA(A/T)AGACT reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for POLE2 Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV Gain+Loss 19812545
esv2748707 CNV Deletion 23290073
esv3082 CNV Deletion 18987735
esv1091889 CNV Deletion 17803354
esv2748709 CNV Deletion 23290073

Relevant External Links for POLE2 Gene

HapMap Linkage Disequilibrium report
POLE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLE2 Gene

Disorders for POLE2 Gene

Relevant External Links for POLE2

Genetic Association Database (GAD)
POLE2
Human Genome Epidemiology (HuGE) Navigator
POLE2

No disorders were found for POLE2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for POLE2 Gene

Publications for POLE2 Gene

  1. The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon. (PMID: 9443964) Jokela M. … Syvaeoja J.E. (Nucleic Acids Res. 1998) 2 3 4
  2. Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon. (PMID: 9405441) Li Y. … Linn S. (J. Biol. Chem. 1997) 2 3 4
  3. The solution structure of the amino-terminal domain of human DNA polymerase epsilon subunit B is homologous to C-domains of AAA+ proteins. (PMID: 18676977) Nuutinen T. … Syvaoja J.E. (Nucleic Acids Res. 2008) 3 23
  4. Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. (PMID: 10801849) Li Y. … Linn S. (J. Biol. Chem. 2000) 3 4
  5. E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase varepsilon B-subunit gene POLE2. (PMID: 11433027) Huang D. … Syvaoja J.E. (Nucleic Acids Res. 2001) 3 4

Products for POLE2 Gene

Sources for POLE2 Gene

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