POLE Gene
protein-coding GIFtS: 67
GCID: GC12M133200
|
|
polymerase (DNA directed), epsilon, catalytic subunit(Previous names: polymerase (DNA directed), epsilon )
| |
Aliases
for POLE gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Polymerase (DNA Directed), Epsilon, Catalytic Subunit1 2 | | Polymerase (DNA Directed), Epsilon1 | | POLE11 2 3 | | CRCS122 | | DNA Polymerase II Subunit A2 3 | | DNA Polymerase Epsilon Catalytic Subunit A2 | | EC 2.7.7.73 8 | | EC 2.7.78 |
Export aliases for POLE gene to outside databasesPrevious GC identifers: GC12U990073 GC12P132569 GC12M132825 GC12M131439 GC12M131810 GC12M131710 GC12M129980 |
Summaries
for POLE gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DPOE1_HUMAN, Q07864Function: Participates in DNA repair and in chromosomal DNA replication
Gene Wiki entry for POLE
|
Genomic Views
for POLE gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_024477.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the POLE gene promoter:
Max Max1 AML1a ATF-2 Nkx2-5 Evi-1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for POLE
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLE |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.3 Ensembl cytogenetic band: 12q24.33 HGNC cytogenetic band: 12q24.3POLE Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M133200: view genomic region
(about GC identifiers)
Start:
|
133,200,345 bp from pter |
End:
|
133,413,387 bp from pter |
Size:
|
213,043 bases |
Orientation:
|
minus strand |
|
Proteins
for POLE gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DPOE1_HUMAN, Q07864 (See
protein sequence)Recommended Name: DNA polymerase epsilon catalytic subunit A Size: 2286 amino acids; 261518 Da
Cofactor: Binds 1 4Fe-4S cluster (By similarity)
Subunit: Catalytic and central component of the epsilon DNA polymerase complex consisting of four subunits: POLE,POLE2, POLE3 and POLE4. Interacts with RAD17 and TOPBP1
Subcellular location: Nucleus
Sequence caution: Sequence=AAA15448.1; Type=Frameshift; Positions=443, 448; Sequence=AAA15448.1; Type=Miscellaneousdiscrepancy;
Secondary accessions: Q13533 Q86VH9Explore the universe of human proteins at neXtProt for POLE: NX_Q07864
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q07864
4/16 DME Specific Peptides for POLE (Q07864) (see all 16)
POLE Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006222.2
ENSEMBL proteins: ENSP00000415058 ENSP00000322570 ENSP00000442578 ENSP00000445753 ENSP00000442519 ENSP00000439052 ENSP00000439842 ENSP00000443213 ENSP00000406383 Reactome Protein details: Q07864
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
POLE for ontologies About GeneDecksing
POLE Antibody Products:
Assay Products for POLE: |
Protein
Domains /
Families
for POLE gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
POLE for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q07864ProtoNet protein and cluster: Q07864 2 Blocks protein families: IPB006134 DNA polymerase B domain IPB013697 Domain of unknown function DUF1744
UniProtKB/Swiss-Prot: DPOE1_HUMAN, Q07864Domain: The DNA polymerase activity domain resides in the N-terminal half of the protein, while the C-terminus isnecessary for complexing subunits B and C. The C-terminus may also regulate the catalytic activities of the enzymeDomain: The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes (By similarity)Similarity: Belongs to the DNA polymerase type-B familySimilarity: Contains 1 CysA-type zinc finger |
Function
for POLE gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DPOE1_HUMAN, Q07864Function: Participates in DNA repair and in chromosomal DNA replicationCatalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)Enzyme Numbers (IUBMB): EC 2.7.7.71 2 EC 2.7.72
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLE (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLE (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: POLE (NM_006231) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POLE | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLE |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLE |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
POLE for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for POLE:
Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Pole):
POLE for phenotypes About GeneDecksing
|
Pathways & Interactions
for POLE gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Lagging Strand Synthesis | | | 2 | Ubiquitinated Orc1 is degraded by the proteasome | | | 3 | Global Genomic NER (GG-NER) | | | 4 | Nucleotide Excision Repair | | | 5 | G1/S Transition | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for POLE
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POLE
1  GeneGo (Thomson Reuters) Pathway for POLE
2  BioSystems Pathways for POLE
5/25 
Reactome Pathways for POLE (see all 25)
5/6 
Kegg Pathways (Kegg details for POLE) (see all 6):
POLE for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POLE
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/716 Interacting proteins for POLE (Q078642, 3 ENSP000003225704) via UniProtKB, MINT, STRING, and/or I2D (see all 716)About this table
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000082 | G1/S transition of mitotic cell cycle |
TAS | -- | | GO:0000084 | S phase of mitotic cell cycle |
TAS | -- | | GO:0000216 | M/G1 transition of mitotic cell cycle |
TAS | -- | | GO:0000278 | mitotic cell cycle |
TAS | -- | | GO:0000722 | telomere maintenance via recombination |
TAS | -- |
POLE for ontologies About GeneDecksing
|
Drugs & Compounds
for POLE gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for POLE
6 HMDB Compounds for POLE About this table
1 DrugBank Compound for POLE About this table
Search CenterWatch for drugs/clinical trials and news about POLE / DPOE1
|
Transcripts
for POLE gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for POLE gene: NM_006231.2 Unigene Cluster for POLE: Polymerase (DNA directed), epsilon, catalytic subunit Hs.524871 [show with all ESTs]Unigene Representative Sequence: BC14456118/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25): ENST00000434528(uc001ukq.1) ENST00000541627 ENST00000320574(uc001uks.1 uc009zyu.1)
ENST00000537064(uc001ukr.1 uc010tbq.1) ENST00000534922 ENST00000535270
ENST00000544692 ENST00000538196 ENST00000543516 ENST00000544870 ENST00000441786
ENST00000541213 ENST00000544414 ENST00000416953 ENST00000542362 ENST00000540987
ENST00000539006 ENST00000536445
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLE (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLE (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: POLE (NM_006231) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POLE | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLE |
Additional cDNA sequence: AF128542.1 AF128544.1 AK025087.1 AK093003.1 AL080203.1 BC007599.1 BC011376.1 BC021559.1 BC087613.1 BC144561.1 L09561.1 S60080.1 U49356.1 17 DOTS entries: DT.445040 DT.100755029 DT.101982981 DT.316471 DT.100755031 DT.92012151 DT.97769357 DT.102831799 DT.95144247 DT.97822386 DT.87015676 DT.121172767 DT.91905918 DT.92354048 DT.120704907 DT.91828132 DT.95171522 24/206 AceView cDNA sequences (see all 206): AI564263 BX493014 AI631774 AI274732 AF128542 R67657 AL046781 BC021559 BU172196 AA768922 BM458272 BM692718 AL043786 BI013194 BQ049812 BU521341 BX644983 BU183348 BQ222760 BQ224205 AA227757 BM477002 BC007599 BM683632
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for POLE (see all 13) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31a | · | 31b | ^ | 32a | · | 32b | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36a | · | 36b | ^ | 37 | ^ | 38 | ^ | 39 | ^ | 40 | ^ | 41 | ^ | 42 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | |
| ExUns: | 43 | ^ | 44a | · | 44b | ^ | 45a | · | 45b | ^ | 46a | · | 46b | · | 46c | ^ | 47a | · | 47b | ^ | 48a | · | 48b | ^ | 49 | ^ | 50 | ^ | 51a | · | 51b | · | 51c |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for POLE
|
Expression
for POLE gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| POLE expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAAATGGG
About this image
See POLE Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POLE
SOURCE GeneReport for Unigene cluster: Hs.524871
SABiosciences Custom PCR Arrays for POLE
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLE
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POLE | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLE | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLE | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLE |
Orthologs
for POLE gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for POLE gene from 33 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chimpanzee
(Pan troglodytes) |
Mammalia |
POLE1 |
DNA polymerase epsilon catalytic subunit A-like |
99.31(n)
99.54(a) |
|
452384 XM_003314035.2 XP_003314083.1 |
mouse
(Mus musculus) |
Mammalia |
Pole1 , 5 |
polymerase (DNA directed), epsilon1, 5 |
86(n)1
91(a)1 |
|
5 (53.45 cM)5
189731 NM_011132.21 NP_035262.21
1102863065 |
cow
(Bos taurus) |
Mammalia |
POLE1 |
polymerase (DNA directed), epsilon, catalytic subunit |
88.28(n)
91.99(a) |
|
785457 NM_001191429.1 NP_001178358.1 |
dog
(Canis familiaris) |
Mammalia |
POLE1 |
polymerase (DNA directed), epsilon, catalytic subunit |
88.05(n)
91.5(a) |
|
486223 XM_543348.3 XP_543348.2 |
oppossum
(Monodelphis domestica) |
Mammalia |
POLE6 |
-- |
88(a) |
1 ↔ 1 |
3(463910354-463991955) |
platypus
(Ornithorhynchus anatinus) |
Mammalia |
----(see all 4) |
-- |
98(a)97(a)(see all 4) |
possible orthologmany → 1(see all 4) |
Contig82622(877-1350) Contig101798(313-884) |
chicken
(Gallus gallus) |
Aves |
POLE1 |
polymerase (DNA directed), epsilon |
79(n)
84.17(a) |
|
416997 XM_001233984.2 XP_001233985.2 |
lizard
(Anolis carolinensis) |
Reptilia |
POLE6 |
-- |
81(a) |
1 ↔ 1 |
GL343417.1(433022-459635) |
African clawed frog
(Xenopus laevis) |
Amphibia |
pole-A2 |
polymerase (DNA directed), epsilon |
75.54(n) |
|
AF202988.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
pole1 |
polymerase (DNA directed), epsilon |
73.72(n)
80.55(a) |
|
553405 NM_001128523.1 NP_001121995.1 |
rainbow trout
(Oncorhynchus mykiss) |
Actinopterygii |
Omy.11642 |
Oncorhynchus mykiss transcribed sequence with moderate more |
76.58(n) |
|
BX857696.1 |
sea squirt
(Ciona savignyi) |
Ascidiacea |
-- |
-- |
57(a) |
1 ↔ 1 |
reftig_48(158985-182246) |
sea urchin
(Strongylocentrotus purpuratus) |
Echinoidea |
----(see all 4) |
-- |
70(a)69(a)(see all 4) |
possible orthologpossible ortholog(see all 4) |
scaffold_5269(8398-27104) scaffold_5269(29617-38708) |
fruit fly
(Drosophila melanogaster) |
Insecta |
DNApol-&egr;3
DNApol-epsilon1 |
DNA dependent DNA replication epsilon DNA
polymerase3
DNA polymerase epsilon1 |
40(a)3
60.8(n)1
58.13(a)1 |
|
94E133
427581 NM_079738.21 NP_524462.21 |
mosquito
(Anopheles gambiae) |
Insecta |
AgaP_AGAP0046151 |
AGAP004615-PA |
57.42(n)
58.24(a) |
|
1275917 XM_315205.3 XP_315205.3 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
55(a) |
1 ↔ 1 |
Group10.15(212149-221079) |
worm
(Caenorhabditis elegans) |
Secernentea |
F33H2.51 , 3 |
DNA polymerase family B (3 domains)3
Protein F33H2.51 |
43(a)3
51.47(n)1
47.2(a)1 |
|
I(15013741-15021915)3
1733681 NM_061215.21 NP_493616.11 |
schistosome parasite
(Schistosoma mansoni) |
Trematoda |
Smp_1461706 |
DNA polymerase |
33(a) |
1 ↔ 1 |
Smp_scaff000110(196069-272302) |
common water flea
(Daphnia pulex) |
Crustacea |
----(see all 6) |
-- |
61(a)58(a)(see all 6) |
possible orthologpossible ortholog(see all 6) |
scaffold_103(60238-60417) scaffold_79(73943-82248) |
Trichoplax
(Trichoplax adhaerens) |
Tricoplacia |
-- |
-- |
57(a) |
1 ↔ 1 |
scaffold_12(702320-717439) |
sea anemone
(Nematostella vectensis) |
Anthozoa |
-- |
-- |
63(a) |
1 ↔ 1 |
scaffold_166(15942-51319) |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
POL2(YNL262W)4
POL21 |
Catalytic subunit of DNA polymerase (II) epsilon, a more4
Pol2p1 |
48.7(n)1
45.17(a)1 |
|
14(148212-154880)4
8554591, 4 NP_014137.11, 4 |
A. gossypii yeast
(Ashbya gossypii) |
Saccharomycetes |
AGOS_AFR657C1 |
AFR657Cp |
50.01(n)
46.11(a) |
|
4622494 NM_212341.1 NP_986205.1 |
K. lactis yeast
(Kluyveromyces lactis) |
Saccharomycetes |
KLLA0C02585g1 |
hypothetical protein |
49.07(n)
45.5(a) |
|
2892428 XM_452312.1 XP_452312.1 |
fission yeast
(Schizosaccharomyces pombe) |
Schizosaccharomycetes |
cdc201 |
DNA polymerase epsilon catalytic subunit a Pol2 |
48.9(n)
45.91(a) |
|
2540627 NP_596354.1 |
bread mold
(Neurospora crassa) |
Ascomycetes |
NCU045481 |
DNA polymerase epsilon |
53.77(n)
46.14(a) |
|
3872087 XM_950846.2 XP_955939.2 |
stem rust fungus
(Puccinia graminis) |
Pucciniomycetes |
PGTG_173266 |
DNA polymerase epsilon subunit 1 |
43(a) |
1 ↔ 1 |
|
amoeba
(Dictyostelium discoideum) |
Dictyostelia |
POLE6 |
DNA polymerase epsilon catalytic subunit A |
40(a) |
1 ↔ 1 |
4(385928-393596) |
malaria parasite
(Plasmodium falciparum) |
Aconoidasida |
PFF1470c6 |
DNA polymerase epsilon, catalytic subunit a, putat... |
21(a) |
1 ↔ 1 |
06(1260401-1269599) |
Chromalveolata
(Phytophthora infestans) |
Oomycota |
PITG_155056 |
DNA polymerase |
39(a) |
1 ↔ 1 |
supercont1.37(1331151-1338387) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
TIL11 |
DNA polymerase epsilon subunit 1 |
50.43(n)
46.06(a) |
|
837346 NM_100699.5 NP_172303.5 |
rice
(Oryza sativa) |
Liliopsida |
Os02g05119001 |
hypothetical protein |
50.69(n)
46.16(a) |
|
4329458 NM_001053474.2 NP_001046939.2 |
green algae
(Chlamydomonas reinhardtii) |
Chlorophyceae |
POLE16 |
DNA polymerase epsilon catalytic subunit A/1 |
34(a) |
1 ↔ 1 |
DS496116(44362-65464) |
Species with no ortholog for POLE
ENSEMBL Gene Tree for POLE (if available)
TreeFam Gene Tree for POLE (if available) |
Paralogs
for POLE gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for POLE gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for POLE (133200345 - 133413387 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for POLE
1 Indel: 58558 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POLE |
|
Disorders
/ Diseases
for POLE gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
POLE for disorders About GeneDecksing
OMIM gene information: 174762
OMIM disorders: --
20/25  diseases for POLE (see all 25): About MalaCardschronic progressive external ophthalmoplegia human immunodeficiency virus infectious disease graft versus host disease skin tag
xeroderma pigmentosum color blindness herpes zoster alpers syndrome
chronic lymphocytic leukemia lymphocytic leukemia ophthalmoplegia multiple sclerosis
blindness hepatitis b vaccinia encephalitis
hepatocellular carcinoma immunodeficiency colorectal cancer leukemia
2 diseases from the University of Copenhagen DISEASES database for POLE:Tinea corporis Color blindness Human Genome Epidemiology (HuGE) Navigator: POLE (24 documents)
Export disorders for POLE gene to outside databases
|
Publications
for POLE gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for POLE gene, integrated from 9 sources (see all 74):
(articles sorted by number of sources associating them with POLE) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase epsilon. (PubMed id 8486689)1, 2, 9 Kesti T.... Syvaeoja J.E. (1993)
- The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon. (PubMed id 14500819)1, 2 Post S.M.... Lee E.Y.-H.P. (2003)
- BRCT domain-containing protein TopBP1 functions in DNA replication and damage response. (PubMed id 11395493)1, 2 Maekiniemi M.... Syvaeoja J.E. (2001)
- Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. (PubMed id 10801849)1, 2 Li Y.... Linn S. (2000)
- Localization of the gene for DNA polymerase epsilon (POLE) to human chromosome 12q24.3 and rat chromosome 12 by somatic cell hybrid panels and fluorescence in situ hybridization. (PubMed id 8020968)1, 3 Szpirer J....Szpirer C. (1994)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Segregation of replicative DNA polymerases during S ph ase: DNA polymerase e, but not DNA polymerases a/d, are associated with lamins t hroughout S phase in human cells. (PubMed id 22887995)1 Vaara M....Syvaoja J.E. (2012)
- Human DNA polymerase e is able to efficiently extend f rom multiple consecutive ribonucleotides. (PubMed id 23093410)1 Goksenin A.Y....Pursell Z.F. (2012)
- DNA polymerase d and z switch by sharing accessory sub units of DNA polymerase d. (PubMed id 22465957)1 Baranovskiy A.G....Tahirov T.H. (2012)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
|
External Searches for POLE gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing POLE gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing POLE gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing POLE gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for POLE gene:
Search GeneIP for patents involving POLE
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for POLE gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for POLE | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLE | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLE | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for POLE | | OriGene 3'-UTR Clone for POLE | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLE | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLE | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for POLE | | OriGene Custom Protein Services for POLE | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POLE | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POLE | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLE | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLE | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLE | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLE |
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|  |  |  | | | | ThermoFisher Antibodies for POLE |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLE |
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