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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

POLE Gene

protein-coding GIFtS: 67
GCID: GC12M133200

polymerase (DNA directed), epsilon, catalytic subunit

(Previous names: polymerase (DNA directed), epsilon )

Explore 25 diseases affiliated with
POLE via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Polymerase (DNA Directed), Epsilon, Catalytic Subunit¹ ²		Polymerase (DNA Directed), Epsilon¹
POLE1¹ ² ³		CRCS12²
DNA Polymerase II Subunit A² ³		DNA Polymerase Epsilon Catalytic Subunit A²
EC 2.7.7.7³ ⁸		EC 2.7.7⁸

External Ids:	HGNC: 9177¹	Entrez Gene: 5426²	Ensembl: ENSG00000177084⁷	OMIM: 174762⁵	UniProtKB: Q07864³

Export aliases for POLE gene to outside databases

Previous GC identifers: GC12U990073 GC12P132569 GC12M132825 GC12M131439 GC12M131810 GC12M131710 GC12M129980

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DPOE1_HUMAN, Q07864

Function: Participates in DNA repair and in chromosomal DNA replication

Gene Wiki entry for POLE

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_024477.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the POLE gene promoter:
Max Max1 AML1a ATF-2 Nkx2-5 Evi-1 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): POLE promoter sequence

Search SABiosciences Chromatin IP Primers for POLE

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLE

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.3 Ensembl cytogenetic band: 12q24.33 HGNC cytogenetic band: 12q24.3

POLE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLE gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M133200: view genomic region (about GC identifiers)

Start:	133,200,345 bp from pter	End:	133,413,387 bp from pter
Size:	213,043 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DPOE1_HUMAN, Q07864 (See protein sequence)

Recommended Name: DNA polymerase epsilon catalytic subunit A

Size: 2286 amino acids; 261518 Da

Cofactor: Binds 1 4Fe-4S cluster (By similarity)

Subunit: Catalytic and central component of the epsilon DNA polymerase complex consisting of four subunits: POLE,

POLE2, POLE3 and POLE4. Interacts with RAD17 and TOPBP1

Subcellular location: Nucleus

Sequence caution: Sequence=AAA15448.1; Type=Frameshift; Positions=443, 448; Sequence=AAA15448.1; Type=Miscellaneous

discrepancy;

Secondary accessions: Q13533 Q86VH9

Explore the universe of human proteins at neXtProt for POLE: NX_Q07864

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q07864

4/16 DME Specific Peptides for POLE (Q07864) (see all 16)

LITNREI

DTDGIWC

VMRKGAR

LAFDIET

POLE Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006222.2

ENSEMBL proteins:

ENSP00000415058 ENSP00000322570 ENSP00000442578 ENSP00000445753 ENSP00000442519

ENSP00000439052 ENSP00000439842 ENSP00000443213 ENSP00000406383

Reactome Protein details: Q07864
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for POLE
	GenScript Custom Purified and Recombinant Proteins Services for POLE
	Novus Biologicals POLE Protein Novus Biologicals POLE Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	16762037
GO:0005654	nucleoplasm	TAS	--
GO:0008622	epsilon DNA polymerase complex	IDA	10801849

POLE for ontologies About GeneDecksing

POLE Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of POLE
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for POLE
	GenScript Custom Superior Antibodies Services for POLE
	Novus Biologicals POLE Antibodies
	Abcam antibodies for POLE
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for POLE

Assay Products for POLE:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for POLE
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

POLE for domains About GeneDecksing

5 InterPro domains/families:

IPR006172 DNA-dir_DNA_pol_B

IPR006133 DNA-dir_DNA_pol_B_exonuc

IPR006134 DNA-dir_DNA_pol_B_multi_dom

IPR013697 DNA_pol_e_suA_C

IPR012337 RNaseH-like_dom

Graphical View of Domain Structure for InterPro Entry Q07864

ProtoNet protein and cluster: Q07864

2 Blocks protein families:

IPB006134 DNA polymerase B domain

IPB013697 Domain of unknown function DUF1744

UniProtKB/Swiss-Prot: DPOE1_HUMAN, Q07864

Domain: The DNA polymerase activity domain resides in the N-terminal half of the protein, while the C-terminus is

necessary for complexing subunits B and C. The C-terminus may also regulate the catalytic activities of the enzyme

Domain: The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes (By similarity)

Similarity: Belongs to the DNA polymerase type-B family

Similarity: Contains 1 CysA-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DPOE1_HUMAN, Q07864

Function: Participates in DNA repair and in chromosomal DNA replication

Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

Enzyme Numbers (IUBMB): EC 2.7.7.7¹ ² EC 2.7.7²

miRNA Products:		OriGene 3'-UTR Clone: POLE Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLE
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate POLE
		SwitchGear 3'UTR luciferase reporter plasmid: POLE 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLE (see all 7) OriGene shRNA RFP: POLE OriGene siRNA: POLE
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLE

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for POLE

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLE (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLE (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: POLE (NM_006231)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLE
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLE

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for POLE
		Search LifeMap BioReagents cell lines for POLE

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLE

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IDA	16762037
GO:0003682	chromatin binding	IDA	16762037
GO:0003887	DNA-directed DNA polymerase activity	IMP	16762037

POLE for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for POLE:

Increased S DNA content

S arrest

Synthetic lethal with Ras

Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pole):

hematopoietic system

immune system

integument

mortality/aging

tumorigenesis

POLE for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Lagging Strand Synthesis

8/10 pathways (see all 10)
Telomere C-strand (Lagging Strand) Synthesis	0.91	Repair synthesis for gap-filling by DNA polymerase in TC-NER	0.59
Extension of Telomeres	0.83	DNA replication	0.56
Gap-filling DNA repair synthesis and ligation in TC-NER	0.64	Mismatch Repair in Eukaryotes	0.33
Gap-filling DNA repair synthesis and ligation in GG-NER	0.64	DNA replication initiation	0.18

Ubiquitinated Orc1 is degraded by the proteasome

DNA Replication Pre-Initiation	0.62	DNA Replication	0.49
M/G1 Transition	0.62	S Phase	0.40
Synthesis of DNA	0.51

Global Genomic NER (GG-NER)

	Global Genomic NER (GG-NER)	1.00			Nucleotide Excision Repair Pathway	0.49
	Nucleotide excision repair	0.70

Nucleotide Excision Repair

	Nucleotide Excision Repair	1.00			DNA Repair	0.46
	Transcription-coupled NER (TC-NER)	0.90

G1/S Transition

G1/S Transition

1.00

Mitotic G1-G1/S phases

0.80

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for POLE

Cell cycle Transition and termination of DNA replacation

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POLE

	Mismatch Repair in Eukaryotes
	DNA Repair Mechanisms
	Nucleotide Excision Repair Pathway
	Cell Cycle Control of Chromosomal Replication

1 GeneGo (Thomson Reuters) Pathway for POLE

Cell cycle Transition and termination of DNA replication

2 BioSystems Pathways for POLE

	G1 to S cell cycle control
	DNA Replication

5/25 Reactome Pathways for POLE (see all 25)

	Extension of Telomeres
	Telomere Maintenance
	DNA Repair
	Mitotic G1-G1/S phases
	Repair synthesis for gap-filling by DNA polymerase in TC-NER

5/6 Kegg Pathways (Kegg details for POLE) (see all 6):

	Purine metabolism
	Pyrimidine metabolism
	Metabolic pathways
	DNA replication
	Base excision repair

POLE for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for POLE

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

706/716 Interacting proteins for POLE (Q07864^{2, 3} ENSP00000322570⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 716) (see top 5)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=2
HIST1H4B	P62805³	I2D: score=2
HIST1H4C	P62805³	I2D: score=2
HIST1H4D	P62805³	I2D: score=2
HIST1H4E	P62805³	I2D: score=2
HIST1H4F	P62805³	I2D: score=2
HIST1H4H	P62805³	I2D: score=2
HIST1H4I	P62805³	I2D: score=2
HIST1H4J	P62805³	I2D: score=2
HIST1H4K	P62805³	I2D: score=2
HIST1H4L	P62805³	I2D: score=2
HIST2H4A	P62805³	I2D: score=2
HIST2H4B	P62805³	I2D: score=2
HIST4H4	P62805³	I2D: score=2
MSH6	P52701²^,³, ENSP00000234420⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000234420
TIAL1	Q01085²^,³	MINT-7945693 I2D: score=4
BTAF1	O14981²^,³	MINT-7945693 I2D: score=1
DDX5	P17844²^,³	MINT-7945693 I2D: score=1
DNAJA1	P31689²^,³	MINT-7945693 I2D: score=1
DRG1	Q9Y295²^,³	MINT-7945693 I2D: score=1
EEF1A1	P68104²^,³	MINT-7945693 I2D: score=1
GTPBP4	Q9BZE4²^,³	MINT-7945693 I2D: score=1
IPO9	Q96P70²^,³	MINT-7945693 I2D: score=1
POLD1	P28340²^,³	MINT-7945693 I2D: score=1
PWP1	Q13610²^,³	MINT-7945693 I2D: score=1
SMARCA5	O60264²^,³	MINT-7945693 I2D: score=1
SNRPD3	P62318²^,³	MINT-7945693 I2D: score=1
UPF1	Q92900²^,³	MINT-7945693 I2D: score=1
RFC2	P35250²^,³, ENSP00000055077⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000055077
RFC3	P40938²^,³, ENSP00000369411⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000369411
MSH2	P43246²^,³, ENSP00000233146⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000233146
FEN1	P39748²^,³, ENSP00000305480⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000305480
MRE11A	P49959²^,³, ENSP00000325863⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000325863
SMC1A	Q14683²^,³, ENSP00000323421⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000323421
RFC4	P35249²^,³, ENSP00000296273⁴	MINT-7945693 I2D: score=2 STRING: ENSP00000296273
RFC5	P40937²^,³, ENSP00000408295⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000408295
PCNA	P12004³, ENSP00000368438⁴	I2D: score=4 STRING: ENSP00000368438
POLE3	Q9NRF9³, ENSP00000363284⁴	I2D: score=3 STRING: ENSP00000363284
POLE4	Q9NR33³, ENSP00000420176⁴	I2D: score=3 STRING: ENSP00000420176
RAD17	O75943³, ENSP00000370151⁴	I2D: score=3 STRING: ENSP00000370151
STK19	P49842³, ENSP00000364482⁴	I2D: score=3 STRING: ENSP00000364482
H3F3A	P84243³	I2D: score=2
H3F3B	P84243³	I2D: score=2
POLE2	P56282³, ENSP00000216367⁴	I2D: score=11 STRING: ENSP00000216367
LIG4	P49917³, ENSP00000349393⁴	I2D: score=1 STRING: ENSP00000349393
MDM2	Q00987³, ENSP00000417281⁴	I2D: score=1 STRING: ENSP00000417281
MSH3	P20585³, ENSP00000265081⁴	I2D: score=1 STRING: ENSP00000265081
PAPD5	Q8NDF8³, ENSP00000396995⁴	I2D: score=1 STRING: ENSP00000396995
PMS2	P54278³, ENSP00000265849⁴	I2D: score=1 STRING: ENSP00000265849
PRIM1	P49642³, ENSP00000350491⁴	I2D: score=1 STRING: ENSP00000350491
RNASEH2A	O75792³, ENSP00000221486⁴	I2D: score=1 STRING: ENSP00000221486
RPA1	P27694³, ENSP00000254719⁴	I2D: score=1 STRING: ENSP00000254719
UBE2V2	Q15819³, ENSP00000326473⁴	I2D: score=1 STRING: ENSP00000326473
POLA1	P09884³, ENSP00000368349⁴	I2D: score=3 STRING: ENSP00000368349
TOPBP1	Q92547³, ENSP00000260810⁴	I2D: score=3 STRING: ENSP00000260810
MYC	P01106³, ENSP00000367207⁴	I2D: score=3 STRING: ENSP00000367207
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
MCM2	P49736³, ENSP00000265056⁴	I2D: score=3 STRING: ENSP00000265056
ASF1A	Q9Y294³, ENSP00000229595⁴	I2D: score=1 STRING: ENSP00000229595
EIF4E	P06730³, ENSP00000280892⁴	I2D: score=4 STRING: ENSP00000280892
ATR	Q13535², ENSP00000343741⁴	MINT-7945693 STRING: ENSP00000343741
CDC14A	Q9UNH5³, ENSP00000354916⁴	I2D: score=1 STRING: ENSP00000354916
BLM	P54132², ENSP00000347232⁴	MINT-7945693 STRING: ENSP00000347232
ORC2	Q13416², ENSP00000234296⁴	MINT-7945693 STRING: ENSP00000234296
ORC3	Q9UBD5², ENSP00000257789⁴	MINT-7945693 STRING: ENSP00000257789
SNW1	Q13573², ENSP00000261531⁴	MINT-7945693 STRING: ENSP00000261531
HIST2H2BF	Q5QNW6³	I2D: score=4
HSPA9	P38646³	I2D: score=3
HIST1H2AC	Q93077³	I2D: score=2
PPP1CC	P36873³	I2D: score=2
XRCC5	P13010³	I2D: score=2
ATP6V1B2	P21281³	I2D: score=1
BOP1	Q14137³	I2D: score=1
CFL1	P23528³	I2D: score=1
DDX10	Q13206³	I2D: score=1
DDX18	Q9NVP1³	I2D: score=1
DDX54	Q8TDD1³	I2D: score=1
DEPDC5	O75140³	I2D: score=1
DLST	P36957³	I2D: score=1
EIF6	P56537³	I2D: score=1
GMPPB	Q9Y5P6³	I2D: score=1
GNB2L1	P63244³	I2D: score=1
GNL3	Q9BVP2³	I2D: score=1
GPI	P06744³	I2D: score=1
H2AFX	P16104³	I2D: score=1
HAT1	O14929³	I2D: score=1
KIAA0020	Q15397³	I2D: score=1
NAP1L4	Q99733³	I2D: score=1
NAT10	Q9H0A0³	I2D: score=1
NOC3L	Q8WTT2³	I2D: score=1
NOL10	Q9BSC4³	I2D: score=1
NOL6	Q9H6R4³	I2D: score=1
NOP56	O00567³	I2D: score=1
PDCD11	Q14690³	I2D: score=1
PDIA4	P13667³	I2D: score=1
PES1	O00541³	I2D: score=1
POLL	Q9UGP5³	I2D: score=1
POLR1B	Q9H9Y6³	I2D: score=1
POLR3A	O14802³	I2D: score=1
POLR3B	Q9NW08³	I2D: score=1
PRIM2	P49643³	I2D: score=1
PRKAR2A	P13861³	I2D: score=1
PUS7	Q96PZ0³	I2D: score=1
RBM28	Q9NW13³	I2D: score=1
RPS27A	P62979³	I2D: score=1
RPS6	P62753³	I2D: score=1
RRP12	Q5JTH9³	I2D: score=1
SMARCA4	P51532³	I2D: score=1
SSRP1	Q08945³	I2D: score=1
SUPT16H	Q9Y5B9³	I2D: score=1
SUPT5H	O00267³	I2D: score=1
TOP1	P11387³	I2D: score=1
TXN	P10599³	I2D: score=1
UBA52	P62987³	I2D: score=1
UTP20	O75691³	I2D: score=1
VPS13A	Q96RL7³	I2D: score=1
ABCF1	Q8NE71²	MINT-7945693
ABCF3	Q9NUQ8²	MINT-7945693
ACIN1	Q9UKV3²	MINT-7945693
ACTB	P60709²	MINT-7945693
ACTL6A	O96019²	MINT-7945693
ACTR1A	P61163²	MINT-7945693
ACTR2	P61160²	MINT-7945693
ADNP	Q9H2P0²	MINT-7945693
AHNAK	Q09666²	MINT-7945693
ANAPC1	Q9H1A4²	MINT-7945693
ANLN	Q9NQW6²	MINT-7945693
AP1B1	Q10567²	MINT-7945693
AP3B1	O00203²	MINT-7945693
APBB1IP	Q7Z5R6²	MINT-7945693
API5	Q9BZZ5²	MINT-7945693
AQR	O60306²	MINT-7945693
ARAP1	Q96P48²	MINT-7945693
ARCN1	P48444²	MINT-7945693
ARF4	P18085²	MINT-7945693
ARF5	P84085²	MINT-7945693
ARFGEF2	Q9Y6D5²	MINT-7945693
ARHGEF1	Q92888²	MINT-7945693
ARHGEF2	Q92974²	MINT-7945693
ARID1A	O14497²	MINT-7945693
ASUN	Q9NVM9²	MINT-7945693
ATM	Q13315²	MINT-7945693
ATRX	P46100²	MINT-7945693
AURKA	O14965²	MINT-7945693
AURKB	Q96GD4²	MINT-7945693
BABAM1	Q9NWV8²	MINT-7945693
BAZ1A	Q9NRL2²	MINT-7945693
BCAS2	O75934²	MINT-7945693
BCL7C	Q8WUZ0²	MINT-7945693
BCLAF1	Q9NYF8²	MINT-7945693
BRD8	Q9H0E9²	MINT-7945693
BRIX1	Q8TDN6²	MINT-7945693
BUB1	O43683²	MINT-7945693
BUB1B	O60566²	MINT-7945693
BUB3	O43684²	MINT-7945693
BZW1	Q7L1Q6²	MINT-7945693
BZW2	Q9Y6E2²	MINT-7945693
C22orf28	Q9Y3I0²	MINT-7945693
C7orf55-LUC7L2	Q9Y383²	MINT-7945693
CAND1	Q86VP6²	MINT-7945693
CAPG	P40121²	MINT-7945693
CAPZA1	P52907²	MINT-7945693
CCNB1	P14635²	MINT-7945693
CCNT1	O60563²	MINT-7945693
CCT2	P78371²	MINT-7945693
CCT3	P49368²	MINT-7945693
CCT4	P50991²	MINT-7945693
CCT5	P48643²	MINT-7945693
CCT6A	P40227²	MINT-7945693
CCT7	Q99832²	MINT-7945693
CCT8	P50990²	MINT-7945693
CDC16	Q13042²	MINT-7945693
CDC23	Q9UJX2²	MINT-7945693
CDC27	P30260²	MINT-7945693
CDC5L	Q99459²	MINT-7945693
CDC73	Q6P1J9²	MINT-7945693
CDK1	P06493²	MINT-7945693
CDK12	Q9NYV4²	MINT-7945693
CDK3	Q00526²	MINT-7945693
CDK9	P50750²	MINT-7945693
CDKN2AIP	Q9NXV6²	MINT-7945693
CHD1L	Q86WJ1²	MINT-7945693
CHD3	Q12873²	MINT-7945693
CHD4	Q14839²	MINT-7945693
CHD7	Q9P2D1²	MINT-7945693
CHD8	Q9HCK8²	MINT-7945693
CHEK1	O14757²	MINT-7945693
CKAP5	Q14008²	MINT-7945693
CLP1	Q92989²	MINT-7945693
COPA	P53621²	MINT-7945693
COPB1	P53618²	MINT-7945693
COPB2	P35606²	MINT-7945693
COPG1	Q9Y678²	MINT-7945693
COPG2	Q9UBF2²	MINT-7945693
COPS3	Q9UNS2²	MINT-7945693
COPS5	Q92905²	MINT-7945693
COPS6	Q7L5N1²	MINT-7945693
CPNE3	O75131²	MINT-7945693
CPSF1	Q10570²	MINT-7945693
CPSF2	Q9P2I0²	MINT-7945693
CPSF3	Q9UKF6²	MINT-7945693
CPSF4	O95639²	MINT-7945693
CPSF7	Q8N684²	MINT-7945693
CSDA	P16989²	MINT-7945693
CSE1L	P55060²	MINT-7945693
CSK	P41240²	MINT-7945693
CSTF3	Q12996²	MINT-7945693
CTTN	Q14247²	MINT-7945693
CUL1	Q13616²	MINT-7945693
DCTN1	Q14203²	MINT-7945693
DCTN2	Q13561²	MINT-7945693
DDX1	Q92499²	MINT-7945693
DDX17	Q92841²	MINT-7945693
DDX19A	Q9NUU7²	MINT-7945693
DDX19B	Q9UMR2²	MINT-7945693
DDX21	Q9NR30²	MINT-7945693
DDX23	Q9BUQ8²	MINT-7945693
DDX39A	O00148²	MINT-7945693
DDX39B	Q13838²	MINT-7945693
DDX3X	O00571²	MINT-7945693
DDX41	Q9UJV9²	MINT-7945693
DDX42	Q86XP3²	MINT-7945693
DDX46	Q7L014²	MINT-7945693
DEPDC7	Q96QD5²	MINT-7945693
DFNA5	O60443²	MINT-7945693
DHX8	Q14562²	MINT-7945693
DHX9	Q08211²	MINT-7945693
DIAPH1	O60610²	MINT-7945693
DIAPH3	Q9NSV4²	MINT-7945693
DIDO1	Q9BTC0²	MINT-7945693
DMAP1	Q9NPF5²	MINT-7945693
DNAJC13	O75165²	MINT-7945693
DNM1L	O00429²	MINT-7945693
DNM2	P50570²	MINT-7945693
DOCK1	Q14185²	MINT-7945693
DOCK2	Q92608²	MINT-7945693
DPF2	Q92785²	MINT-7945693
DSP	P15924²	MINT-7945693
DYNC1H1	Q14204²	MINT-7945693
DYNC1LI2	O43237²	MINT-7945693
EBNA1BP2	Q99848²	MINT-7945693
EEFSEC	P57772²	MINT-7945693
EFTUD2	Q15029²	MINT-7945693
EHD1	Q9H4M9²	MINT-7945693
EHD4	Q9H223²	MINT-7945693
EIF2S1	P05198²	MINT-7945693
EIF2S2	P20042²	MINT-7945693
EIF2S3	P41091²	MINT-7945693
EIF3E	P60228²	MINT-7945693
EIF3G	O75821²	MINT-7945693
EIF3H	O15372²	MINT-7945693
EIF3I	Q13347²	MINT-7945693
EIF3L	Q9Y262²	MINT-7945693
EIF4A1	P60842²	MINT-7945693
EIF4A3	P38919²	MINT-7945693
EIF4G2	P78344²	MINT-7945693
EIF5B	O60841²	MINT-7945693
ELAVL1	Q15717²	MINT-7945693
ENAH	Q8N8S7²	MINT-7945693
ENSG00000258947	Q13509²	MINT-7945693
ENSG00000266714	Q96JP2²	MINT-7945693
EPPK1	P58107²	MINT-7945693
EPS8L2	Q9H6S3²	MINT-7945693
ETF1	P62495²	MINT-7945693
ETV6	P41212²	MINT-7945693
EXOC1	Q9NV70²	MINT-7945693
EXOC2	Q96KP1²	MINT-7945693
EXOC3	O60645²	MINT-7945693
EXOC4	Q96A65²	MINT-7945693
EXOC5	O00471²	MINT-7945693
EXOC7	Q9UPT5²	MINT-7945693
EXOSC10	Q01780²	MINT-7945693
EXOSC6	Q5RKV6²	MINT-7945693
FAM105B	Q96BN8²	MINT-7945693
FAM129B	Q96TA1²	MINT-7945693
FANCI	Q9NVI1²	MINT-7945693
FASN	P49327²	MINT-7945693
FERMT1	Q9BQL6²	MINT-7945693
FHOD1	Q9Y613²	MINT-7945693
FIP1L1	Q6UN15²	MINT-7945693
FUBP1	Q96AE4²	MINT-7945693
FUS	P35637²	MINT-7945693
FYTTD1	Q96QD9²	MINT-7945693
G3BP2	Q9UN86²	MINT-7945693
GATAD2A	Q86YP4²	MINT-7945693
GATAD2B	Q8WXI9²	MINT-7945693
GCN1L1	Q92616²	MINT-7945693
GEMIN4	P57678²	MINT-7945693
GNA14	O95837²	MINT-7945693
GSPT1	P15170²	MINT-7945693
GTF2I	P78347²	MINT-7945693
GTF3C1	Q12789²	MINT-7945693
GTF3C2	Q8WUA4²	MINT-7945693
GTF3C3	Q9Y5Q9²	MINT-7945693
GTF3C4	Q9UKN8²	MINT-7945693
GULP1	Q9UBP9²	MINT-7945693
HBS1L	Q9Y450²	MINT-7945693
HDAC1	Q13547²	MINT-7945693
HDAC2	Q92769²	MINT-7945693
HDLBP	Q00341²	MINT-7945693
HELLS	Q9NRZ9²	MINT-7945693
HIP1R	O75146²	MINT-7945693
HIRA	P54198²	MINT-7945693
HLTF	Q14527²	MINT-7945693
HNRNPA0	Q13151²	MINT-7945693
HNRNPA1	P09651²	MINT-7945693
HNRNPA2B1	P22626²	MINT-7945693
HNRNPA3	P51991²	MINT-7945693
HNRNPAB	Q99729²	MINT-7945693
HNRNPC	P07910²	MINT-7945693
HNRNPD	Q14103²	MINT-7945693
HNRNPF	P52597²	MINT-7945693
HNRNPH1	P31943²	MINT-7945693
HNRNPK	P61978²	MINT-7945693
HNRNPM	P52272²	MINT-7945693
HNRNPR	O43390²	MINT-7945693
HNRNPU	Q00839²	MINT-7945693
HSP90AA1	P07900²	MINT-7945693
HSP90AB1	P08238²	MINT-7945693
HSP90B1	P14625²	MINT-7945693
HSPA12A	O43301²	MINT-7945693
HSPA5	P11021²	MINT-7945693
HSPA8	P11142²	MINT-7945693
HSPB1	P04792²	MINT-7945693
HSPD1	P10809²	MINT-7945693
HTATSF1	O43719²	MINT-7945693
IK	Q13123²	MINT-7945693
ILF2	Q12905²	MINT-7945693
ILF3	Q12906²	MINT-7945693
ILK	Q13418²	MINT-7945693
INTS1	Q8N201²	MINT-7945693
INTS12	Q96CB8²	MINT-7945693
INTS3	Q68E01²	MINT-7945693
IPO5	O00410²	MINT-7945693
IQGAP1	P46940²	MINT-7945693
KDM1A	O60341²	MINT-7945693
KHDRBS1	Q07666²	MINT-7945693
KIAA1279	Q96EK5²	MINT-7945693
KIF11	P52732²	MINT-7945693
KIF21A	Q7Z4S6²	MINT-7945693
KIF27	Q86VH2²	MINT-7945693
KIF2C	Q99661²	MINT-7945693
KIF4A	O95239²	MINT-7945693
KPNA1	P52294²	MINT-7945693
KPNA2	P52292²	MINT-7945693
KPNB1	Q14974²	MINT-7945693
KTI12	Q96EK9²	MINT-7945693
LDLRAP1	Q5SW96²	MINT-7945693
LIMS1	P48059²	MINT-7945693
LMNA	P02545²	MINT-7945693
LRRC40	Q9H9A6²	MINT-7945693
LRRC47	Q8N1G4²	MINT-7945693
LRWD1	Q9UFC0²	MINT-7945693
LUC7L2	Q9Y383²	MINT-7945693
MAD1L1	Q9Y6D9²	MINT-7945693
MAGED2	Q9UNF1²	MINT-7945693
MAP2K2	P36507²	MINT-7945693
MAP2K3	P46734²	MINT-7945693
MAP2K7	O14733²	MINT-7945693
MATR3	P43243²	MINT-7945693
MBD3	O95983²	MINT-7945693
MDN1	Q9NU22²	MINT-7945693
MED4	Q9NPJ6²	MINT-7945693
METTL13	Q8N6R0²	MINT-7945693
MLH1	P40692²	MINT-7945693
MLKL	Q8NB16²	MINT-7945693
MLL2	O14686²	MINT-7945693
MORF4L1	Q9UBU8²	MINT-7945693
MORF4L2	Q15014²	MINT-7945693
MTA2	O94776²	MINT-7945693
MVP	Q14764²	MINT-7945693
MYH9	P35579²	MINT-7945693
MYO15B	Q96JP2²	MINT-7945693
NACC1	Q96RE7²	MINT-7945693
NBN	O60934²	MINT-7945693
NCAPD2	Q15021²	MINT-7945693
NCAPG	Q9BPX3²	MINT-7945693
NCAPH	Q15003²	MINT-7945693
NCL	P19338²	MINT-7945693
NCOR1	O75376²	MINT-7945693
NCOR2	Q9Y618²	MINT-7945693
NDC80	O14777²	MINT-7945693
NELFB	Q8WX92²	MINT-7945693
NELFCD	Q8IXH7²	MINT-7945693
NFIC	P08651²	MINT-7945693
NIPBL	Q6KC79²	MINT-7945693
NOLC1	Q14978²	MINT-7945693
NONO	Q15233²	MINT-7945693
NR2C2	P49116²	MINT-7945693
NR2F2	P24468²	MINT-7945693
NR2F6	P10588²	MINT-7945693
NSF	P46459²	MINT-7945693
NSUN5	Q96P11²	MINT-7945693
NUDC	Q9Y266²	MINT-7945693
NUF2	Q9BZD4²	MINT-7945693
NUP153	P49790²	MINT-7945693
NUP155	O75694²	MINT-7945693
NUP37	Q8NFH4²	MINT-7945693
OLA1	Q9NTK5²	MINT-7945693
OXSR1	O95747²	MINT-7945693
PABPC1	P11940²	MINT-7945693
PABPN1	Q86U42²	MINT-7945693
PAK1	Q13153²	MINT-7945693
PAK4	O96013²	MINT-7945693
PARP4	Q9UKK3²	MINT-7945693
PARVA	Q9NVD7²	MINT-7945693
PARVB	Q9HBI1²	MINT-7945693
PAXIP1	Q6ZW49²	MINT-7945693
PBRM1	Q86U86²	MINT-7945693
PCBP2	Q15366²	MINT-7945693
PCF11	O94913²	MINT-7945693
PDCD6IP	Q8WUM4²	MINT-7945693
PDLIM7	Q9NR12²	MINT-7945693
PELP1	Q8IZL8²	MINT-7945693
PFKM	P08237²	MINT-7945693
PFKP	Q01813²	MINT-7945693
PHGDH	O43175²	MINT-7945693
PICALM	Q13492²	MINT-7945693
PIK3R4	Q99570²	MINT-7945693
PKN2	Q16513²	MINT-7945693
PKP3	Q9Y446²	MINT-7945693
PLEC	Q15149²	MINT-7945693
PLK1	P53350²	MINT-7945693
PLRG1	O43660²	MINT-7945693
PNN	Q9H307²	MINT-7945693
POGZ	Q7Z3K3²	MINT-7945693
POLE	Q07864²	MINT-7945693
POLR1C	O15160²	MINT-7945693
POLR2A	P24928²	MINT-7945693
POLR2E	P19388²	MINT-7945693
PPP1CA	P62136²	MINT-7945693
PPP2R1A	P30153²	MINT-7945693
PPP2R1B	P30154²	MINT-7945693
PRKAG1	P54619²	MINT-7945693
PRKDC	P78527²	MINT-7945693
PRPF19	Q9UMS4²	MINT-7945693
PRPF40A	O75400²	MINT-7945693
PRPF6	O94906²	MINT-7945693
PRPF8	Q6P2Q9²	MINT-7945693
PSMC1	P62191²	MINT-7945693
PSMC2	P35998²	MINT-7945693
PSMC3	P17980²	MINT-7945693
PSMC4	P43686²	MINT-7945693
PSMC5	P62195²	MINT-7945693
PSMC6	P62333²	MINT-7945693
PSMD1	Q99460²	MINT-7945693
PSMD11	O00231²	MINT-7945693
PSMD12	O00232²	MINT-7945693
PSMD13	Q9UNM6²	MINT-7945693
PSMD2	Q13200²	MINT-7945693
PSMD3	O43242²	MINT-7945693
PTBP1	P26599²	MINT-7945693
PUF60	Q9UHX1²	MINT-7945693
PUM2	Q8TB72²	MINT-7945693
PURA	Q00577²	MINT-7945693
RACGAP1	Q9H0H5²	MINT-7945693
RAD18	Q9NS91²	MINT-7945693
RAD21	O60216²	MINT-7945693
RAD50	Q92878²	MINT-7945693
RAE1	P78406²	MINT-7945693
RALY	Q9UKM9²	MINT-7945693
RANBP2	P49792²	MINT-7945693
RANGAP1	P46060²	MINT-7945693
RBBP5	Q15291²	MINT-7945693
RBBP7	Q16576²	MINT-7945693
RBM10	P98175²	MINT-7945693
RBM14	Q96PK6²	MINT-7945693
RBM15	Q96T37²	MINT-7945693
RBM17	Q96I25²	MINT-7945693
RBM39	Q14498²	MINT-7945693
RBM4	Q9BWF3²	MINT-7945693
RBM45	Q8IUH3²	MINT-7945693
RBMX	P38159²	MINT-7945693
RCOR1	Q9UKL0²	MINT-7945693
RIF1	Q5UIP0²	MINT-7945693
RING1	Q06587²	MINT-7945693
RIOK1	Q9BRS2²	MINT-7945693
RNF2	Q99496²	MINT-7945693
ROCK2	O75116²	MINT-7945693
RPL12	P30050²	MINT-7945693
RPL13	P26373²	MINT-7945693
RPL19	P84098²	MINT-7945693
RPL22	P35268²	MINT-7945693
RPL23A	P62750²	MINT-7945693
RPL3	P39023²	MINT-7945693
RPL31	P62899²	MINT-7945693
RPL36	Q9Y3U8²	MINT-7945693
RPL4	P36578²	MINT-7945693
RPL7A	P62424²	MINT-7945693
RPL8	P62917²	MINT-7945693
RPLP0	P05388²	MINT-7945693
RPS14	P62263²	MINT-7945693
RPS18	P62269²	MINT-7945693
RPS19	P39019²	MINT-7945693
RPS25	P62851²	MINT-7945693
RPS3	P23396²	MINT-7945693
RPS6KA4	O75676²	MINT-7945693
RPS6KB2	Q9UBS0²	MINT-7945693
RUVBL1	Q9Y265²	MINT-7945693
RUVBL2	Q9Y230²	MINT-7945693
SART1	O43290²	MINT-7945693
SCYL2	Q6P3W7²	MINT-7945693
SEC23B	Q15437²	MINT-7945693
SEC31B	Q9NQW1²	MINT-7945693
SEH1L	Q96EE3²	MINT-7945693
SEPT7	Q16181²	MINT-7945693
SEPT9	Q9UHD8²	MINT-7945693
SETX	Q7Z333²	MINT-7945693
SF3A1	Q15459²	MINT-7945693
SF3A3	Q12874²	MINT-7945693
SF3B1	O75533²	MINT-7945693
SF3B14	Q9Y3B4²	MINT-7945693
SF3B2	Q13435²	MINT-7945693
SF3B3	Q15393²	MINT-7945693
SF3B4	Q15427²	MINT-7945693
SFPQ	P23246²	MINT-7945693
SHOC2	Q9UQ13²	MINT-7945693
SHROOM3	Q8TF72²	MINT-7945693
SMARCA2	P51531²	MINT-7945693
SMARCAD1	Q9H4L7²	MINT-7945693
SMARCB1	Q12824²	MINT-7945693
SMARCC1	Q92922²	MINT-7945693
SMARCC2	Q8TAQ2²	MINT-7945693
SMARCD1	Q96GM5²	MINT-7945693
SMARCE1	Q969G3²	MINT-7945693
SMC2	O95347²	MINT-7945693
SMC3	Q9UQE7²	MINT-7945693
SMC4	Q9NTJ3²	MINT-7945693
SMCHD1	A6NHR9²	MINT-7945693
SMN1	Q16637²	MINT-7945693
SMN2	Q16637²	MINT-7945693
SND1	Q7KZF4²	MINT-7945693
SNRNP200	O75643²	MINT-7945693
SNRNP40	Q96DI7²	MINT-7945693
SNRNP70	P08621²	MINT-7945693
SNRPB2	P08579²	MINT-7945693
SNUPN	O95149²	MINT-7945693
SPATA5	Q8NB90²	MINT-7945693
SPATA5L1	Q9BVQ7²	MINT-7945693
SPTAN1	Q13813²	MINT-7945693
SPTBN1	Q01082²	MINT-7945693
SQSTM1	Q13501²	MINT-7945693
SRP19	P09132²	MINT-7945693
SRP54	P61011²	MINT-7945693
SRP68	Q9UHB9²	MINT-7945693
SRP72	O76094²	MINT-7945693
SRRM1	Q8IYB3²	MINT-7945693
SRRM2	Q9UQ35²	MINT-7945693
SRSF1	Q07955²	MINT-7945693
SRSF11	Q05519²	MINT-7945693
SRSF2	Q01130²	MINT-7945693
SRSF3	P84103²	MINT-7945693
SRSF5	Q13243²	MINT-7945693
SRSF6	Q13247²	MINT-7945693
SRSF7	Q16629²	MINT-7945693
STAG1	Q8WVM7²	MINT-7945693
SUGT1	Q9Y2Z0²	MINT-7945693
SUPV3L1	Q8IYB8²	MINT-7945693
SYMPK	Q92797²	MINT-7945693
SYNCRIP	O60506²	MINT-7945693
TAF12	Q16514²	MINT-7945693
TAF9	Q16594²	MINT-7945693
TAOK1	Q7L7X3²	MINT-7945693
TARDBP	Q13148²	MINT-7945693
TBL1XR1	Q9BZK7²	MINT-7945693
TCP1	P17987²	MINT-7945693
THOC1	Q96FV9²	MINT-7945693
THOC2	Q8NI27²	MINT-7945693
THRAP3	Q9Y2W1²	MINT-7945693
TLN1	Q9Y490²	MINT-7945693
TMPO	P42166²	MINT-7945693
TOX4	O94842²	MINT-7945693
TRAP1	Q12931²	MINT-7945693
TRIM28	Q13263²	MINT-7945693
TRIP12	Q14669²	MINT-7945693
TRIP13	Q15645²	MINT-7945693
TRUB1	Q8WWH5²	MINT-7945693
TSG101	Q99816²	MINT-7945693
TTK	P33981²	MINT-7945693
TUBA3E	Q6PEY2²	MINT-7945693
TUBA4A	P68366²	MINT-7945693
TUBB	P07437²	MINT-7945693
TUBB1	Q9H4B7²	MINT-7945693
TUBB3	Q13509²	MINT-7945693
TUBB4B	P68371²	MINT-7945693
TUBG1	P23258²	MINT-7945693
TUBGCP2	Q9BSJ2²	MINT-7945693
TUBGCP3	Q96CW5²	MINT-7945693
TUFM	P49411²	MINT-7945693
TWF1	Q12792²	MINT-7945693
U2AF1	Q01081²	MINT-7945693
U2AF2	P26368²	MINT-7945693
U2SURP	O15042²	MINT-7945693
UBA5	Q9GZZ9²	MINT-7945693
UBE2M	P61081²	MINT-7945693
UBE2N	P61088²	MINT-7945693
UBE2Q1	Q7Z7E8²	MINT-7945693
UBL4A	P11441²	MINT-7945693
UCHL5	Q9Y5K5²	MINT-7945693
UNC45A	Q9H3U1²	MINT-7945693
UPF2	Q9HAU5²	MINT-7945693
USP39	Q53GS9²	MINT-7945693
USP48	Q86UV5²	MINT-7945693
VASP	P50552²	MINT-7945693
VIM	P08670²	MINT-7945693
VPS33B	Q9H267²	MINT-7945693
VRK1	Q99986²	MINT-7945693
WAPAL	Q7Z5K2²	MINT-7945693
WDR18	Q9BV38²	MINT-7945693
WDR33	Q9C0J8²	MINT-7945693
WDR5	P61964²	MINT-7945693
WIZ	O95785²	MINT-7945693
XPO6	Q96QU8²	MINT-7945693
XRCC6	P12956²	MINT-7945693
XRN2	Q9H0D6²	MINT-7945693
YTHDC2	Q9H6S0²	MINT-7945693
YY1	P25490²	MINT-7945693
ZNF326	Q5BKZ1²	MINT-7945693
ZNF638	Q14966²	MINT-7945693
CDC45	ENSP00000263201⁴	STRING: ENSP00000263201
CDC6	ENSP00000209728⁴	STRING: ENSP00000209728
CDC7	ENSP00000234626⁴	STRING: ENSP00000234626
CDK2	ENSP00000266970⁴	STRING: ENSP00000266970
DBF4	ENSP00000265728⁴	STRING: ENSP00000265728
ENTPD1	ENSP00000360248⁴	STRING: ENSP00000360248
ITPA	ENSP00000369456⁴	STRING: ENSP00000369456
MCM10	ENSP00000354945⁴	STRING: ENSP00000354945
MCM3	ENSP00000229854⁴	STRING: ENSP00000229854
MCM4	ENSP00000262105⁴	STRING: ENSP00000262105
MCM5	ENSP00000216122⁴	STRING: ENSP00000216122
MCM6	ENSP00000264156⁴	STRING: ENSP00000264156
MCM7	ENSP00000307288⁴	STRING: ENSP00000307288
NME1	ENSP00000013034⁴	STRING: ENSP00000013034
NME1-NME2	ENSP00000376886⁴	STRING: ENSP00000376886
NME3	ENSP00000219302⁴	STRING: ENSP00000219302
NME4	ENSP00000219479⁴	STRING: ENSP00000219479
NME6	ENSP00000416658⁴	STRING: ENSP00000416658
NME7	ENSP00000356785⁴	STRING: ENSP00000356785
ORC4	ENSP00000264169⁴	STRING: ENSP00000264169
ORC5	ENSP00000297431⁴	STRING: ENSP00000297431
ORC6	ENSP00000219097⁴	STRING: ENSP00000219097
PKLR	ENSP00000339933⁴	STRING: ENSP00000339933
PKM	ENSP00000320171⁴	STRING: ENSP00000320171
POLA2	ENSP00000265465⁴	STRING: ENSP00000265465
RFC1	ENSP00000261424⁴	STRING: ENSP00000261424
RPA3	ENSP00000223129⁴	STRING: ENSP00000223129
RPA4	ENSP00000362131⁴	STRING: ENSP00000362131
ENTPD3	ENSP00000301825⁴	STRING: ENSP00000301825
ENTPD8	ENSP00000360561⁴	STRING: ENSP00000360561
NME5	ENSP00000265191⁴	STRING: ENSP00000265191
GINS4	ENSP00000276533⁴	STRING: ENSP00000276533
POLD4	ENSP00000311368⁴	STRING: ENSP00000311368
GAR1	ENSP00000226796⁴	STRING: ENSP00000226796
SUMO1	ENSP00000376076⁴	STRING: ENSP00000376076
HUS1	ENSP00000258774⁴	STRING: ENSP00000258774
DKC1	ENSP00000358563⁴	STRING: ENSP00000358563
SIRT7	ENSP00000329466⁴	STRING: ENSP00000329466
GINS1	ENSP00000262460⁴	STRING: ENSP00000262460
ASF1B	ENSP00000263382⁴	STRING: ENSP00000263382
PAPD7	ENSP00000230859⁴	STRING: ENSP00000230859
PIF1	ENSP00000268043⁴	STRING: ENSP00000268043
CDC14B	ENSP00000364389⁴	STRING: ENSP00000364389
IMPA1	ENSP00000408526⁴	STRING: ENSP00000408526
EIF4E1B	ENSP00000323714⁴	STRING: ENSP00000323714
RRM2B	ENSP00000251810⁴	STRING: ENSP00000251810
IMPA2	ENSP00000269159⁴	STRING: ENSP00000269159
RRM2	ENSP00000302955⁴	STRING: ENSP00000302955
SMC1B	ENSP00000350036⁴	STRING: ENSP00000350036
RAD1	ENSP00000340879⁴	STRING: ENSP00000340879
EXO1	ENSP00000311873⁴	STRING: ENSP00000311873
MMS19	ENSP00000359818⁴	STRING: ENSP00000359818
TIA1	ENSP00000401371⁴	STRING: ENSP00000401371
GAPDH	ENSP00000229239⁴	STRING: ENSP00000229239
UBE2V1	ENSP00000340305⁴	STRING: ENSP00000340305
SUMO2	ENSP00000405965⁴	STRING: ENSP00000405965
SUMO3	ENSP00000330343⁴	STRING: ENSP00000330343
GAPDHS	ENSP00000222286⁴	STRING: ENSP00000222286
MUS81	ENSP00000307853⁴	STRING: ENSP00000307853
GINS3	ENSP00000401018⁴	STRING: ENSP00000401018
--	Q8WU30²	MINT-7945693
--	ENSP00000242630⁴	STRING: ENSP00000242630
--	ENSP00000329528⁴	STRING: ENSP00000329528
--	Q8N532²	MINT-7945693
--	Q7Z48 M²	MINT-7945693
--	XP_292²	MINT-7945693
--	Q9NXK9²	MINT-7945693
--	ENSP00000391798⁴	STRING: ENSP00000391798
--	ENSP00000372817⁴	STRING: ENSP00000372817
--	ENSP00000262266⁴	STRING: ENSP00000262266
--	ENSP00000367784⁴	STRING: ENSP00000367784
--	ENSP00000277916⁴	MINT-7945693 STRING: ENSP00000277916
--	Q9Y4B3²	MINT-7945693
--	ENSP00000399255⁴	STRING: ENSP00000399255
--	Q13727²	MINT-7945693
--	O43209²	MINT-7945693
--	Q9UNL7²	MINT-7945693
--	ENSP00000402620⁴	STRING: ENSP00000402620
--	Q8N1C0²	MINT-7945693
--	Q8N5H6²	MINT-7945693
--	XP_039702²	MINT-7945693
--	Q9HBD4²	MINT-7945693
--	Q9Y2L0²	MINT-7945693
--	XP_086²	MINT-7945693
--	Q96QI3²	MINT-7945693
--	ENSP00000339071⁴	MINT-7945693 STRING: ENSP00000339071
--	Q9NVY6²	MINT-7945693

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000216	M/G1 transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0000722	telomere maintenance via recombination	TAS	--

POLE for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for POLE

6 HMDB Compounds for POLE About this table

Compound	Synonyms	CAS #	PubMed Ids
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--
Thymidine 5'-triphosphate	2'-Deoxythymidine 5'-triphosphate (see all 13)	365-08-2	--
dATP	2'-Deoxy-5'-ATP (see all 8)	1927-31-7	--
dCTP	2'-deoxycytidine-5'-triphosphate (see all 4)	2056-98-6	--
dGTP	2'-Deoxyguanosine 5'-triphosphate (see all 4)	2564-35-4	--

1 DrugBank Compound for POLE About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Cladribine	2-CdA (see all 5)	4291-63-8	target	inhibitor	19576186

Search CenterWatch for drugs/clinical trials and news about POLE / DPOE1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for POLE gene:

NM_006231.2

Unigene Cluster for POLE:

Polymerase (DNA directed), epsilon, catalytic subunit

Hs.524871 [show with all ESTs]

Unigene Representative Sequence: BC144561

18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):

ENST00000434528(uc001ukq.1) ENST00000541627 ENST00000320574(uc001uks.1 uc009zyu.1)

ENST00000537064(uc001ukr.1 uc010tbq.1) ENST00000534922 ENST00000535270

ENST00000544692 ENST00000538196 ENST00000543516 ENST00000544870 ENST00000441786

ENST00000541213 ENST00000544414 ENST00000416953 ENST00000542362 ENST00000540987

ENST00000539006 ENST00000536445

miRNA Products:		OriGene 3'-UTR Clone: POLE Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLE
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate POLE
		SwitchGear 3'UTR luciferase reporter plasmid: POLE 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLE (see all 7) OriGene shRNA RFP: POLE OriGene siRNA: POLE
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLE (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLE (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: POLE (NM_006231)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLE
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLE

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLE Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLE
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLE

Additional cDNA sequence:

AF128542.1 AF128544.1 AK025087.1 AK093003.1 AL080203.1 BC007599.1 BC011376.1 BC021559.1

BC087613.1 BC144561.1 L09561.1 S60080.1 U49356.1

17 DOTS entries:

DT.445040 DT.100755029 DT.101982981 DT.316471 DT.100755031 DT.92012151 DT.97769357 DT.102831799

DT.95144247 DT.97822386 DT.87015676 DT.121172767 DT.91905918 DT.92354048 DT.120704907 DT.91828132

DT.95171522

24/206 AceView cDNA sequences (see all 206):

AI564263 BX493014 AI631774 AI274732 AF128542 R67657 AL046781 BC021559

BU172196 AA768922 BM458272 BM692718 AL043786 BI013194 BQ049812 BU521341

BX644983 BU183348 BQ222760 BQ224205 AA227757 BM477002 BC007599 BM683632

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for POLE (see all 13) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^	15a	·	15b	·	15c	^	16a	·	16b	^	17	^	18	^	19	^	20	^
SP1:							-																														-		-
SP2:
SP3:
SP4:																																							-
SP5:

ExUns:	21	^	22	^	23	^	24	^	25	^	26	^	27a	·	27b	^	28	^	29	^	30	^	31a	·	31b	^	32a	·	32b	^	33	^	34	^	35	^	36a	·	36b	^	37	^	38	^	39	^	40	^	41	^	42	^
SP1:													-																-																		-
SP2:																													-																		-
SP3:
SP4:
SP5:																																					-

ExUns:	43	^	44a	·	44b	^	45a	·	45b	^	46a	·	46b	·	46c	^	47a	·	47b	^	48a	·	48b	^	49	^	50	^	51a	·	51b	·	51c
SP1:									-		-										-				-
SP2:									-		-										-				-
SP3:									-		-										-				-
SP4:
SP5:

ECgene alternative splicing isoforms for POLE

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

POLE expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAAATGGG

About this image
See POLE Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POLE

SOURCE GeneReport for Unigene cluster: Hs.524871

SABiosciences Custom PCR Arrays for POLE

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLE Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat POLE
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLE
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLE

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLE

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLE gene from 10/33 species (see all 33) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pole^{1 , 5}	polymerase (DNA directed), epsilon^{1, 5}	86(n)¹ 91(a)¹		5 (53.45 cM)⁵ 18973¹ NM_011132.2¹ NP_035262.2¹ 110286306⁵
chicken (Gallus gallus)	Aves	POLE¹	polymerase (DNA directed), epsilon	79(n) 84.17(a)		416997 XM_001233984.2 XP_001233985.2
lizard (Anolis carolinensis)	Reptilia	POLE⁶	--	81(a)	1 ↔ 1	GL343417.1(433022-459635)
African clawed frog (Xenopus laevis)	Amphibia	pole-A²	polymerase (DNA directed), epsilon	75.54(n)		AF202988.1
zebrafish (Danio rerio)	Actinopterygii	pole¹	polymerase (DNA directed), epsilon	73.72(n) 80.55(a)		553405 NM_001128523.1 NP_001121995.1
fruit fly (Drosophila melanogaster)	Insecta	DNApol-&egr;³ DNApol-epsilon¹	DNA dependent DNA replication epsilon DNA polymerase³ DNA polymerase epsilon¹	40(a)³ 60.8(n)¹ 58.13(a)¹		94E13³ 42758¹ NM_079738.2¹ NP_524462.2¹
worm (Caenorhabditis elegans)	Secernentea	F33H2.5^{1 , 3}	DNA polymerase family B (3 domains)³ Protein F33H2.5¹	43(a)³ 51.47(n)¹ 47.2(a)¹		I(15013741-15021915)³ 173368¹ NM_061215.2¹ NP_493616.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	POL2(YNL262W)⁴ POL2¹	Catalytic subunit of DNA polymerase (II) epsilon, a more⁴ Pol2p¹	48.7(n)¹ 45.17(a)¹		14(148212-154880)⁴ 855459^{1, 4} NP_014137.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	TIL1¹	DNA polymerase epsilon subunit 1	50.43(n) 46.06(a)		837346 NM_100699.5 NP_172303.5
rice (Oryza sativa)	Liliopsida	Os02g0511900¹	hypothetical protein	50.69(n) 46.16(a)		4329458 NM_001053474.2 NP_001046939.2

ENSEMBL Gene Tree for POLE (if available)
TreeFam Gene Tree for POLE (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5745002^1,2	C,F,	--	129990912(-)	`GGGGGG/-TGGGA`	1	--	int¹		3		NS NA	176
rs199762410^1,2	C	--	129992691(+)	`TTTAAA/GGNNNN`	1	--	int¹		0	--	--	--	--
rs73485103^1,2	C,	--	130041520(+)	`GCAGGC/TAAACA`	1	--	us2k¹		1		WA	2
rs115448456^1,2	C,F,	--	130041610(+)	`AAGGTA/CAAAGC`	1	--	us2k¹		1		WA	118
rs188417235^1,2		--	133199879(+)	`AAATAC/TCCAGC`	1	--	int¹		0	--	--	--	--
rs147621338^1,2		--	133199976(+)	`ACTCAA/GATGCC`	1	--	int¹		0	--	--	--	--
rs5745097^1,2	C,F,	--	133199982(-)	`GCTGCG/AGGCAT`	1	--	int¹		7		NS NA WA	438
rs142239458^1,2		--	133199992(+)	`CTAGCA/CTCACA`	1	--	int¹		0	--	--	--	--
rs5745096^1,2	C,F,	--	133200016(-)	`GGGCGC/TCAGTC`	1	--	int¹		2		NS CSA	176
rs112611346^1,2	C,	--	133200018(+)	`CTGGCG/ACCCAC`	1	--	int¹		1		WA	2

HapMap Linkage Disequilibrium report for POLE (133200345 - 133413387 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for POLE
1 Indel: 58558

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POLE

DNA2.0 Custom Variant and Variant Library Synthesis for POLE

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

POLE for disorders           About GeneDecksing

OMIM gene information: 174762    OMIM disorders: --

20/25 diseases for POLE (see all 25):    About MalaCards

chronic progressive external ophthalmoplegia human immunodeficiency virus infectious disease graft versus host disease skin tag

xeroderma pigmentosum color blindness herpes zoster alpers syndrome

chronic lymphocytic leukemia lymphocytic leukemia ophthalmoplegia multiple sclerosis

blindness hepatitis b vaccinia encephalitis

hepatocellular carcinoma immunodeficiency colorectal cancer leukemia

2 diseases from the University of Copenhagen DISEASES database for POLE:

Tinea corporis Color blindness

Human Genome Epidemiology (HuGE) Navigator: POLE (24 documents)

Export disorders for POLE gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for POLE gene, integrated from 9 sources (see all 74):
(articles sorted by number of sources associating them with POLE)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase epsilon. (PubMed id 8486689)^{1, 2, 9} Kesti T.... Syvaeoja J.E. (1993)
The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon. (PubMed id 14500819)^{1, 2} Post S.M.... Lee E.Y.-H.P. (2003)
BRCT domain-containing protein TopBP1 functions in DNA replication and damage response. (PubMed id 11395493)^{1, 2} Maekiniemi M.... Syvaeoja J.E. (2001)
Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. (PubMed id 10801849)^{1, 2} Li Y.... Linn S. (2000)
Localization of the gene for DNA polymerase epsilon (POLE) to human chromosome 12q24.3 and rat chromosome 12 by somatic cell hybrid panels and fluorescence in situ hybridization. (PubMed id 8020968)^{1, 3} Szpirer J....Szpirer C. (1994)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Segregation of replicative DNA polymerases during S ph ase: DNA polymerase e, but not DNA polymerases a/d, are associated with lamins t hroughout S phase in human cells. (PubMed id 22887995)¹ Vaara M....Syvaoja J.E. (2012)
Human DNA polymerase e is able to efficiently extend f rom multiple consecutive ribonucleotides. (PubMed id 23093410)¹ Goksenin A.Y....Pursell Z.F. (2012)
DNA polymerase d and z switch by sharing accessory sub units of DNA polymerase d. (PubMed id 22465957)¹ Baranovskiy A.G....Tahirov T.H. (2012)
Global landscape of HIV-human protein complexes. (PubMed id 22190034)¹ Jager S....Krogan N.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5426	HGNC: 9177	AceView: POLE	Ensembl:ENSG00000177084	euGenes: HUgn5426
ECgene: POLE	Kegg: 5426	H-InvDB: POLE

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for POLE	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for POLE	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/pole/

Intellectual Property for POLE gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for POLE gene:
Search GeneIP for patents involving POLE

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	EMD Millipore Mono- and Polyclonal Antibodies for the study of POLE
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	Browse OriGene Antibodies		OriGene shRNA RFP for POLE
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLE		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLE
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	OriGene siRNA for POLE		OriGene 3'-UTR Clone for POLE
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for POLE		OriGene Custom Protein Services for POLE
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POLE
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POLE
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLE
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLE
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLE
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLE

	GenScript Custom Purified and Recombinant Proteins Services for POLE		GenScript cDNA clones with any tag delivered in your preferred vector for POLE
	GenScript Custom Assay Services for POLE		GenScript Custom Superior Antibodies Services for POLE
	GenScript Custom overexpressing Cell Line Services for POLE		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLE

	SwitchGear 3'UTR luciferase reporter plasmids for POLE
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ThermoFisher Antibodies for POLE

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLE

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes POLE gene at Home site.

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POLE Gene

polymerase (DNA directed), epsilon, catalytic subunit

Aliases
for POLE gene

Summaries
for POLE gene

Genomic Views
for POLE gene

Proteins
for POLE gene

Protein Domains /
Families
for POLE gene

Function
for POLE gene

Pathways & Interactions
for POLE gene

Drugs & Compounds
for POLE gene

Transcripts
for POLE gene

Expression
for POLE gene

Orthologs
for POLE gene

Paralogs
for POLE gene

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for POLE gene

Disorders / Diseases
for POLE gene

Publications
for POLE gene

External Searches for POLE gene

Genome Databases showing POLE gene

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Specialized Databases showing POLE gene

Intellectual Property
for POLE gene

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for POLE gene

View Random Gene

Advanced Search

Export list of displayed genes

POLE Gene

polymerase (DNA directed), epsilon, catalytic subunit

Aliasesfor POLE gene

Summariesfor POLE gene

Genomic Viewsfor POLE gene

Proteinsfor POLE gene

Protein Domains /Familiesfor POLE gene

Functionfor POLE gene

Pathways & Interactionsfor POLE gene

Drugs & Compoundsfor POLE gene

Transcriptsfor POLE gene

Expression for POLE gene

Orthologsfor POLE gene

Paralogsfor POLE gene

Genomic Variantsfor POLE gene

Disorders / Diseasesfor POLE gene

Publicationsfor POLE gene

External Searches for POLE gene

Genome Databases showing POLE gene

Other Databases showing POLE gene

Specialized Databases showing POLE gene

Intellectual Propertyfor POLE gene

Productsfor POLE gene

View Random Gene

Aliases
for POLE gene

Summaries
for POLE gene

Genomic Views
for POLE gene

Proteins
for POLE gene

Protein Domains /
Families
for POLE gene

Function
for POLE gene

Pathways & Interactions
for POLE gene

Drugs & Compounds
for POLE gene

Transcripts
for POLE gene

Expression
for POLE gene

Orthologs
for POLE gene

Paralogs
for POLE gene

Genomic Variants
for POLE gene

Disorders / Diseases
for POLE gene

Publications
for POLE gene

Intellectual Property
for POLE gene

Products
for POLE gene