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Aliases for POLE Gene

Aliases for POLE Gene

  • DNA Polymerase Epsilon, Catalytic Subunit 2 3 5
  • Polymerase (DNA) Epsilon, Catalytic Subunit 2 3
  • DNA Polymerase Epsilon Catalytic Subunit A 2 3
  • DNA Polymerase II Subunit A 3 4
  • EC 2.7.7.7 4 61
  • POLE1 3 4
  • Polymerase (DNA Directed), Epsilon, Catalytic Subunit 3
  • DNA Polymerase Epsilon Catalytic Subunit Protein 3
  • Polymerase (DNA Directed), Epsilon 2
  • EC 2.7.7 61
  • CRCS12 3
  • FILS 3

External Ids for POLE Gene

Previous GeneCards Identifiers for POLE Gene

  • GC12U990073
  • GC12P132569
  • GC12M132825
  • GC12M131439
  • GC12M131810
  • GC12M131710
  • GC12M133200
  • GC12M129980

Summaries for POLE Gene

Entrez Gene Summary for POLE Gene

  • This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013]

CIViC summary for POLE Gene

GeneCards Summary for POLE Gene

POLE (DNA Polymerase Epsilon, Catalytic Subunit) is a Protein Coding gene. Diseases associated with POLE include Fils Syndrome and Colorectal Cancer 12. Among its related pathways are DNA Double-Strand Break Repair and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template. GO annotations related to this gene include nucleic acid binding and chromatin binding.

UniProtKB/Swiss-Prot for POLE Gene

  • Participates in DNA repair and in chromosomal DNA replication.

Gene Wiki entry for POLE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLE Gene

Genomics for POLE Gene

Regulatory Elements for POLE Gene

Enhancers for POLE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G132622 1.2 Ensembl ENCODE 37.6 +64.7 64656 1.7 PKNOX1 NFIB AGO1 INSM2 SIN3A ZBTB7B FOS RCOR1 CREM ZNF263 POLE ANKLE2 ENSG00000280311 P2RX2
GH12G132600 1.5 FANTOM5 Ensembl ENCODE 22.7 +85.3 85342 4.3 ARID4B SIN3A ZNF48 YY1 GLIS2 ZNF143 KLF13 MXD4 REST KAT8 POLE PXMP2 ENSG00000256632 LRCOL1 P2RX2 ZNF10 GOLGA3 LOC105370094
GH12G132686 1.1 ENCODE 29.2 +0.3 286 2.1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 KLF13 POLE GC12M132685
GH12G132709 1.1 ENCODE 25.6 -23.2 -23214 2.4 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 POLE ZNF605 ZNF140 ANKLE2 ZNF10 GOLGA3 EP400 ZNF84 LRCOL1 PIR53044
GH12G132657 0.6 ENCODE 37.7 +26.8 26773 6.8 CTCF POLR2A MAX MNT ZBTB33 RAD21 POLE PGAM5 ANKLE2 GC12M132685 PIR54548
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLE on UCSC Golden Path with GeneCards custom track

Promoters for POLE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000059542 -376 3001 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 KLF13 MCM3

Genomic Location for POLE Gene

Chromosome:
12
Start:
132,623,753 bp from pter
End:
132,687,524 bp from pter
Size:
63,772 bases
Orientation:
Minus strand

Genomic View for POLE Gene

Genes around POLE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLE Gene

Proteins for POLE Gene

  • Protein details for POLE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07864-DPOE1_HUMAN
    Recommended name:
    DNA polymerase epsilon catalytic subunit A
    Protein Accession:
    Q07864
    Secondary Accessions:
    • Q13533
    • Q86VH9

    Protein attributes for POLE Gene

    Size:
    2286 amino acids
    Molecular mass:
    261518 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
    Quaternary structure:
    • Catalytic and central component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4. Interacts with RAD17 and TOPBP1.
    SequenceCaution:
    • Sequence=AAA15448.1; Type=Frameshift; Positions=443, 448; Evidence={ECO:0000305}; Sequence=AAA15448.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

neXtProt entry for POLE Gene

Selected DME Specific Peptides for POLE Gene

Q07864:
  • DTDGIWC
  • ILNSFYGY
  • KKRYAVFN
  • YSVSDAVATY
  • ENSIFFE
  • LYDSLQLAHK
  • LITNREI
  • PDEVLRKG
  • LAFDIET
  • NGDFFDWPF
  • DGSLAELKGFE
  • VMRKGAR
  • ELKGFEVKRRGEL
  • ETYVGGHVE
  • NREIVSEDI
  • MMISYMIDG

Post-translational modifications for POLE Gene

  • Ubiquitination at Lys431, posLast=21102110, and Lys2124
  • Modification sites at PhosphoSitePlus

Domains & Families for POLE Gene

Gene Families for POLE Gene

Graphical View of Domain Structure for InterPro Entry

Q07864

UniProtKB/Swiss-Prot:

DPOE1_HUMAN :
  • The DNA polymerase activity domain resides in the N-terminal half of the protein, while the C-terminus is necessary for complexing subunits B and C. The C-terminus may also regulate the catalytic activities of the enzyme.
  • Belongs to the DNA polymerase type-B family.
Domain:
  • The DNA polymerase activity domain resides in the N-terminal half of the protein, while the C-terminus is necessary for complexing subunits B and C. The C-terminus may also regulate the catalytic activities of the enzyme.
  • The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.
Family:
  • Belongs to the DNA polymerase type-B family.
genes like me logo Genes that share domains with POLE: view

Function for POLE Gene

Molecular function for POLE Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
UniProtKB/Swiss-Prot Function:
Participates in DNA repair and in chromosomal DNA replication.

Enzyme Numbers (IUBMB) for POLE Gene

Gene Ontology (GO) - Molecular Function for POLE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IDA,IEA 16762037
GO:0003682 chromatin binding IDA 16762037
GO:0003887 DNA-directed DNA polymerase activity IMP,IEA 16762037
genes like me logo Genes that share ontologies with POLE: view
genes like me logo Genes that share phenotypes with POLE: view

Human Phenotype Ontology for POLE Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for POLE

Inhibitory RNA Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for POLE Gene

Localization for POLE Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLE Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLE gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for POLE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 16762037
GO:0005654 nucleoplasm TAS,IDA --
GO:0005886 plasma membrane IDA --
GO:0008622 epsilon DNA polymerase complex IDA,IEA 10801849
genes like me logo Genes that share ontologies with POLE: view

Pathways & Interactions for POLE Gene

genes like me logo Genes that share pathways with POLE: view

Gene Ontology (GO) - Biological Process for POLE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000722 telomere maintenance via recombination TAS --
GO:0000731 DNA synthesis involved in DNA repair IMP 1730053
GO:0006260 DNA replication IMP,IEA 16762037
GO:0006270 DNA replication initiation TAS --
genes like me logo Genes that share ontologies with POLE: view

No data available for SIGNOR curated interactions for POLE Gene

Drugs & Compounds for POLE Gene

(5) Drugs for POLE Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cladribine Approved, Investigational Pharma Target, inhibitor Apoptosis inducer in CLL cells 73
Phosphoric acid Approved Pharma 0
dctp Experimental Pharma 0
Deoxyadenosine triphosphate Experimental Pharma 0
dgtp Experimental Pharma 0

(2) Additional Compounds for POLE Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • 5-Methyl-dUTP
  • Deoxy-TTP
365-08-2
genes like me logo Genes that share compounds with POLE: view

Transcripts for POLE Gene

Unigene Clusters for POLE Gene

Polymerase (DNA directed), epsilon, catalytic subunit:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLE Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^
SP1: - - -
SP2: - -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 43 ^ 44a · 44b ^ 45a · 45b ^ 46a · 46b · 46c ^ 47a · 47b ^ 48a · 48b ^ 49 ^ 50 ^ 51a · 51b · 51c
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5:
SP6: - - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for POLE Gene

GeneLoc Exon Structure for
POLE
ECgene alternative splicing isoforms for
POLE

Expression for POLE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for POLE Gene

This gene is overexpressed in Brain - Cerebellum (x4.5) and Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for POLE Gene

This gene is overexpressed in Lavage (49.0) and Monocytes (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POLE Gene



NURSA nuclear receptor signaling pathways regulating expression of POLE Gene:

POLE

SOURCE GeneReport for Unigene cluster for POLE Gene:

Hs.524871

Evidence on tissue expression from TISSUES for POLE Gene

  • Blood(4.3)
  • Nervous system(3.4)
  • Intestine(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for POLE Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • integumentary
  • lymphatic
  • respiratory
  • skeleton
Organs:
Head and neck:
  • cheek
  • face
  • forehead
  • head
  • jaw
  • maxilla
  • mouth
  • skull
General:
  • blood
  • blood vessel
  • bone marrow
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with POLE: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for POLE Gene

Orthologs for POLE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLE 34
  • 99.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 98 (a)
OneToMany
-- 35
  • 97 (a)
OneToMany
-- 35
  • 88 (a)
OneToMany
-- 35
  • 86 (a)
OneToMany
cow
(Bos Taurus)
Mammalia POLE 34 35
  • 88.25 (n)
dog
(Canis familiaris)
Mammalia POLE 34 35
  • 88.11 (n)
oppossum
(Monodelphis domestica)
Mammalia POLE 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pole 34
  • 86.19 (n)
mouse
(Mus musculus)
Mammalia Pole 34 16 35
  • 86.13 (n)
chicken
(Gallus gallus)
Aves POLE 34 35
  • 79.04 (n)
lizard
(Anolis carolinensis)
Reptilia POLE 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pole 34
  • 73.01 (n)
African clawed frog
(Xenopus laevis)
Amphibia pole-A 34
zebrafish
(Danio rerio)
Actinopterygii pole 34 35
  • 73.72 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1164 34
fruit fly
(Drosophila melanogaster)
Insecta DNApol-epsilon 34 35
  • 60.35 (n)
DNApol-egr 36
  • 40 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004615 34
  • 57.36 (n)
worm
(Caenorhabditis elegans)
Secernentea F33H2.5 36 34 35
  • 51.63 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR657C 34
  • 50.04 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C02585g 34
  • 49.78 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POL2 34 35 37
  • 48.91 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons TIL1 34
  • 50.54 (n)
rice
(Oryza sativa)
Liliopsida Os02g0511900 34
  • 50.76 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 57 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU04548 34
  • 53.73 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdc20 34
  • 48.64 (n)
Species where no ortholog for POLE was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLE Gene

ENSEMBL:
Gene Tree for POLE (if available)
TreeFam:
Gene Tree for POLE (if available)

Paralogs for POLE Gene

genes like me logo Genes that share paralogs with POLE: view

No data available for Paralogs for POLE Gene

Variants for POLE Gene

Sequence variations from dbSNP and Humsavar for POLE Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs483352909 other, Colorectal cancer 12 (CRCS12) [MIM:615083] 132,673,664(-) ATAAT(C/G/T)TCAAG nc-transcript-variant, upstream-variant-2KB, reference, missense
VAR_069343 Colorectal cancer 12 (CRCS12) [MIM:615083]
VAR_077350 Colorectal cancer 12 (CRCS12) [MIM:615083]
rs398122515 Pathogenic 132,643,404(-) CAGGT(A/G)TGGCC intron-variant
rs1057517612 Likely benign 132,642,493(-) CAGTA(C/T)TGTCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLE Gene

Variant ID Type Subtype PubMed ID
esv1667239 CNV deletion 17803354
esv2422284 CNV deletion 17116639
esv2665414 CNV deletion 23128226
esv2747031 CNV deletion 23290073
esv2747032 CNV deletion 23290073
esv3367737 CNV duplication 20981092
esv3631307 CNV loss 21293372
esv3631308 CNV gain 21293372
nsv1037074 CNV gain 25217958
nsv1047500 CNV gain 25217958
nsv512304 CNV loss 21212237
nsv561109 CNV loss 21841781
nsv561110 CNV loss 21841781
nsv820101 CNV loss 19587683
nsv952512 CNV deletion 24416366

Variation tolerance for POLE Gene

Residual Variation Intolerance Score: 2.77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.99; 87.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLE Gene

Human Gene Mutation Database (HGMD)
POLE
SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLE Gene

Disorders for POLE Gene

MalaCards: The human disease database

(8) MalaCards diseases for POLE Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
fils syndrome
  • facial dysmorphism, immunodeficiency, livedo, and short stature
colorectal cancer 12
  • crcs12
polymerase proofreading-related adenomatous polyposis
  • ppap
colorectal cancer susceptibility 12
  • crcs12
endometrioid ovary carcinoma
  • endometrioid carcinoma of ovary
- elite association - COSMIC cancer census association via MalaCards
Search POLE in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DPOE1_HUMAN
  • Colorectal cancer 12 (CRCS12) [MIM:615083]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. CRCS12 is characterized by a high-penetrance predisposition to the development of colorectal adenomas and carcinomas, with a variable tendency to develop multiple and large tumors. Onset is usually before age 40 years. The histologic features of the tumors are unremarkable. {ECO:0000269 PubMed:23263490, ECO:0000269 PubMed:24501277, ECO:0000269 PubMed:25860647, ECO:0000269 PubMed:27573199}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Facial dysmorphism, immunodeficiency, livedo, and short stature (FILS) [MIM:615139]: A syndrome characterized by mild facial dysmorphism, mainly malar hypoplasia, livedo on the skin since birth, and immunodeficiency resulting in recurrent infections. Growth impairment is observed during early childhood and results in variable short stature in adulthood. {ECO:0000269 PubMed:23230001}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for POLE

Genetic Association Database (GAD)
POLE
Human Genome Epidemiology (HuGE) Navigator
POLE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLE
genes like me logo Genes that share disorders with POLE: view

No data available for Genatlas for POLE Gene

Publications for POLE Gene

  1. Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase epsilon. (PMID: 8486689) Kesti T. … Syvaeoja J.E. (J. Biol. Chem. 1993) 3 4 22 64
  2. New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis. (PMID: 24501277) Valle L. … Blanco I. (Hum. Mol. Genet. 2014) 3 4 64
  3. Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. (PMID: 23263490) Palles C. … Tomlinson I. (Nat. Genet. 2013) 3 4 64
  4. Polymerase epsilon1 mutation in a human syndrome with facial dysmorphism, immunodeficiency, livedo, and short stature (FILS syndrome). (PMID: 23230001) Pachlopnik Schmid J. … de Saint Basile G. (J. Exp. Med. 2012) 3 4 64
  5. Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. (PMID: 20496165) Monsees G.M. … Han J. (Breast Cancer Res. Treat. 2011) 3 46 64

Products for POLE Gene

Sources for POLE Gene

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