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Aliases for POLDIP2 Gene

Aliases for POLDIP2 Gene

  • DNA Polymerase Delta Interacting Protein 2 2 3 5
  • Polymerase (DNA-Directed), Delta Interacting Protein 2 2 3
  • 38 KDa DNA Polymerase Delta Interaction Protein 3 4
  • PDIP38 3 4
  • POLD4 3 4
  • P38 3 4
  • Polymerase (DNA) Delta Interacting Protein 2 3
  • Polymerase Delta Interacting Protein 38 3
  • Polymerase Delta-Interacting Protein 2 3

External Ids for POLDIP2 Gene

Previous GeneCards Identifiers for POLDIP2 Gene

  • GC17M026819
  • GC17M023697
  • GC17M026673
  • GC17M022882

Summaries for POLDIP2 Gene

Entrez Gene Summary for POLDIP2 Gene

  • This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit, as well as with proliferating cell nuclear antigen. The encoded protein maybe play a role in the ability of the replication fork to bypass DNA lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for POLDIP2 Gene

POLDIP2 (DNA Polymerase Delta Interacting Protein 2) is a Protein Coding gene.

Gene Wiki entry for POLDIP2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLDIP2 Gene

Genomics for POLDIP2 Gene

Regulatory Elements for POLDIP2 Gene

Enhancers for POLDIP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F028393 0.8 Ensembl ENCODE 23.3 -39.3 -39278 5.7 BCOR GTF2F1 TBP TFAP4 TAL1 JUN ZFP64 ZMYM3 RARA POLR2A POLDIP2 VTN SARM1 TMEM199 MIR4723 TNFAIP1 IFT20 FOXN1 UNC119 PIGS
GH17F028333 0.2 ENCODE 12.2 +20.7 20723 5.9 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ITM2BP1 RPL23A TMEM97 NEK8 POLDIP2 NUFIP2 ENSG00000264577 ENSG00000265474 VTN TNFAIP1
GH17F028403 1.2 Ensembl ENCODE 10.7 -48.8 -48832 5.1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 ZNF121 GLIS2 NUFIP2 NEK8 ENSG00000264577 ENSG00000265474 POLDIP2 ITM2BP1 TMEM97 NOS2 SLC46A1 LOC105371713
GH17F028250 1 Ensembl ENCODE 5.3 +106.1 106060 1.7 ATF1 PKNOX1 SIN3A ZNF2 ZNF143 ZNF263 REST SREBF1 SMARCA4 PBX2 POLDIP2 TMEM97 GC17M028252 LOC105371712
GH17F028259 0.4 ENCODE 5.2 +99.2 99200 0.2 YY1 POLDIP2 ENSG00000263788 GC17M028781 PIR53864
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around POLDIP2 on UCSC Golden Path with GeneCards custom track

Promoters for POLDIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001343343 89 1801 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 ZHX2 MXD4

Genomic Location for POLDIP2 Gene

Chromosome:
17
Start:
28,346,628 bp from pter
End:
28,357,589 bp from pter
Size:
10,962 bases
Orientation:
Minus strand

Genomic View for POLDIP2 Gene

Genes around POLDIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLDIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLDIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLDIP2 Gene

Proteins for POLDIP2 Gene

  • Protein details for POLDIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2S7-PDIP2_HUMAN
    Recommended name:
    Polymerase delta-interacting protein 2
    Protein Accession:
    Q9Y2S7
    Secondary Accessions:
    • B2R846
    • Q96JE4

    Protein attributes for POLDIP2 Gene

    Size:
    368 amino acids
    Molecular mass:
    42033 Da
    Quaternary structure:
    • Interacts with PCNA and POLD2.

neXtProt entry for POLDIP2 Gene

Post-translational modifications for POLDIP2 Gene

  • Ubiquitination at Lys 223
  • Modification sites at PhosphoSitePlus

Other Protein References for POLDIP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for POLDIP2

No data available for DME Specific Peptides for POLDIP2 Gene

Domains & Families for POLDIP2 Gene

Protein Domains for POLDIP2 Gene

Suggested Antigen Peptide Sequences for POLDIP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2S7

UniProtKB/Swiss-Prot:

PDIP2_HUMAN :
  • Contains 1 apaG domain.
Domain:
  • Contains 1 apaG domain.
genes like me logo Genes that share domains with POLDIP2: view

No data available for Gene Families for POLDIP2 Gene

Function for POLDIP2 Gene

Gene Ontology (GO) - Molecular Function for POLDIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with POLDIP2: view
genes like me logo Genes that share phenotypes with POLDIP2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLDIP2 Gene

Localization for POLDIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLDIP2 Gene

Gene Ontology (GO) - Cellular Components for POLDIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA,IDA --
GO:0042645 mitochondrial nucleoid IDA 18063578
genes like me logo Genes that share ontologies with POLDIP2: view

No data available for Subcellular locations from COMPARTMENTS for POLDIP2 Gene

Pathways & Interactions for POLDIP2 Gene

SuperPathways for POLDIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for POLDIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016242 negative regulation of macroautophagy IEA --
GO:0045931 positive regulation of mitotic cell cycle IEA --
GO:0070584 mitochondrion morphogenesis IEA --
genes like me logo Genes that share ontologies with POLDIP2: view

No data available for Pathways by source and SIGNOR curated interactions for POLDIP2 Gene

Transcripts for POLDIP2 Gene

mRNA/cDNA for POLDIP2 Gene

Unigene Clusters for POLDIP2 Gene

Polymerase (DNA-directed), delta interacting protein 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLDIP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for POLDIP2 Gene

GeneLoc Exon Structure for
POLDIP2
ECgene alternative splicing isoforms for
POLDIP2

Expression for POLDIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POLDIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for POLDIP2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.4).

Protein differential expression in normal tissues from HIPED for POLDIP2 Gene

This gene is overexpressed in Adrenal (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLDIP2 Gene



Protein tissue co-expression partners for POLDIP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLDIP2 Gene:

POLDIP2

SOURCE GeneReport for Unigene cluster for POLDIP2 Gene:

Hs.241543
genes like me logo Genes that share expression patterns with POLDIP2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for POLDIP2 Gene

Orthologs for POLDIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for POLDIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLDIP2 34
  • 99.31 (n)
cow
(Bos Taurus)
Mammalia POLDIP2 34 35
  • 92.3 (n)
dog
(Canis familiaris)
Mammalia POLDIP2 34 35
  • 92.12 (n)
oppossum
(Monodelphis domestica)
Mammalia POLDIP2 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLDIP2 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Poldip2 34 16 35
  • 89.67 (n)
chicken
(Gallus gallus)
Aves POLDIP2 35
  • 85 (a)
OneToOne
TSR1 34
  • 79.61 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia poldip2 34
  • 73.56 (n)
Str.6271 34
zebrafish
(Danio rerio)
Actinopterygii poldip2 34
  • 71.4 (n)
Dr.1683 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001153 34
  • 64.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12162 34 35
  • 63.48 (n)
worm
(Caenorhabditis elegans)
Secernentea tag-307 34 35
  • 47.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8578 35
  • 45 (a)
OneToOne
Species where no ortholog for POLDIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLDIP2 Gene

ENSEMBL:
Gene Tree for POLDIP2 (if available)
TreeFam:
Gene Tree for POLDIP2 (if available)

Paralogs for POLDIP2 Gene

(1) SIMAP similar genes for POLDIP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with POLDIP2: view

No data available for Paralogs for POLDIP2 Gene

Variants for POLDIP2 Gene

Sequence variations from dbSNP and Humsavar for POLDIP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs369488804 Pathogenic 28,357,690(+) GCTTG(C/G/T)GGGCG upstream-variant-2KB, reference, missense
rs782531869 Pathogenic 28,357,762(+) GCTGC(C/G)GGCCG upstream-variant-2KB, reference, missense
rs869025586 Pathogenic 28,357,710(+) TGCGT(C/G)CTTTG upstream-variant-2KB, reference, missense
rs1053195 -- 28,347,687(-) CCCTG(A/G)TAGGG nc-transcript-variant, utr-variant-3-prime
rs1065361 -- 28,347,790(-) CTTGG(A/C)CACCC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for POLDIP2 Gene

Variant ID Type Subtype PubMed ID
nsv1056839 CNV gain 25217958
nsv2017 CNV insertion 18451855
nsv519388 CNV loss 19592680
nsv574653 CNV gain 21841781

Variation tolerance for POLDIP2 Gene

Gene Damage Index Score: 1.51; 29.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLDIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLDIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLDIP2 Gene

Disorders for POLDIP2 Gene

Relevant External Links for POLDIP2

Genetic Association Database (GAD)
POLDIP2
Human Genome Epidemiology (HuGE) Navigator
POLDIP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLDIP2

No disorders were found for POLDIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLDIP2 Gene

Publications for POLDIP2 Gene

  1. Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen. (PMID: 12522211) Liu L. … Lee M.Y.W.T. (J. Biol. Chem. 2003) 2 3 4 64
  2. Complex sense-antisense architecture of TNFAIP1/POLDIP2 on 17q11.2 represents a novel transcriptional structural-functional gene module involved in breast cancer progression. (PMID: 20158880) Grinchuk O.V. … Kuznetsov V.A. (BMC Genomics 2010) 3 22 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38. (PMID: 17623671) Klaile E. … Lucka L. (J. Biol. Chem. 2007) 3 22 64
  5. Further characterization of human DNA polymerase delta interacting protein 38. (PMID: 15811854) Xie B. … Lee M.Y. (J. Biol. Chem. 2005) 3 22 64

Products for POLDIP2 Gene

Sources for POLDIP2 Gene

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