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Aliases for POLDIP2 Gene

Aliases for POLDIP2 Gene

  • Polymerase (DNA) Delta Interacting Protein 2 2 3
  • Polymerase (DNA-Directed), Delta Interacting Protein 2 2 3 5
  • 38 KDa DNA Polymerase Delta Interaction Protein 3 4
  • PDIP38 3 4
  • POLD4 3 4
  • P38 3 4
  • Polymerase Delta Interacting Protein 38 3

External Ids for POLDIP2 Gene

Previous GeneCards Identifiers for POLDIP2 Gene

  • GC17M026819
  • GC17M023697
  • GC17M026673
  • GC17M022882

Summaries for POLDIP2 Gene

Entrez Gene Summary for POLDIP2 Gene

  • This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit, as well as with proliferating cell nuclear antigen. The encoded protein maybe play a role in the ability of the replication fork to bypass DNA lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for POLDIP2 Gene

POLDIP2 (Polymerase (DNA) Delta Interacting Protein 2) is a Protein Coding gene.

Gene Wiki entry for POLDIP2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLDIP2 Gene

Genomics for POLDIP2 Gene

Regulatory Elements for POLDIP2 Gene

Enhancers for POLDIP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POLDIP2 on UCSC Golden Path with GeneCards custom track

Promoters for POLDIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POLDIP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for POLDIP2 Gene

28,346,628 bp from pter
28,357,589 bp from pter
10,962 bases
Minus strand

Genomic View for POLDIP2 Gene

Genes around POLDIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLDIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLDIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLDIP2 Gene

Proteins for POLDIP2 Gene

  • Protein details for POLDIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Polymerase delta-interacting protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R846
    • Q96JE4

    Protein attributes for POLDIP2 Gene

    368 amino acids
    Molecular mass:
    42033 Da
    Quaternary structure:
    • Interacts with PCNA and POLD2.

neXtProt entry for POLDIP2 Gene

Proteomics data for POLDIP2 Gene at MOPED

Post-translational modifications for POLDIP2 Gene

  • Ubiquitination at Lys 223
  • Modification sites at PhosphoSitePlus

Other Protein References for POLDIP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POLDIP2 Gene

Domains & Families for POLDIP2 Gene

Protein Domains for POLDIP2 Gene

Suggested Antigen Peptide Sequences for POLDIP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 apaG domain.
  • Contains 1 apaG domain.
genes like me logo Genes that share domains with POLDIP2: view

No data available for Gene Families for POLDIP2 Gene

Function for POLDIP2 Gene

genes like me logo Genes that share phenotypes with POLDIP2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLDIP2 Gene

Localization for POLDIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLDIP2 Gene

Gene Ontology (GO) - Cellular Components for POLDIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042645 mitochondrial nucleoid IDA 18063578
genes like me logo Genes that share ontologies with POLDIP2: view

No data available for Subcellular locations from COMPARTMENTS for POLDIP2 Gene

Pathways & Interactions for POLDIP2 Gene

SuperPathways for POLDIP2 Gene

No Data Available

Interacting Proteins for POLDIP2 Gene

Gene Ontology (GO) - Biological Process for POLDIP2 Gene


No data available for Pathways by source and SIGNOR curated interactions for POLDIP2 Gene

Drugs & Compounds for POLDIP2 Gene

No Compound Related Data Available

Transcripts for POLDIP2 Gene

mRNA/cDNA for POLDIP2 Gene

Unigene Clusters for POLDIP2 Gene

Polymerase (DNA-directed), delta interacting protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLDIP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for POLDIP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POLDIP2 Gene

mRNA expression in normal human tissues for POLDIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for POLDIP2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.4).

Protein differential expression in normal tissues from HIPED for POLDIP2 Gene

This gene is overexpressed in Adrenal (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for POLDIP2 Gene

SOURCE GeneReport for Unigene cluster for POLDIP2 Gene Hs.241543

genes like me logo Genes that share expression patterns with POLDIP2: view

Protein tissue co-expression partners for POLDIP2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for POLDIP2 Gene

Orthologs for POLDIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for POLDIP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia POLDIP2 35
  • 92.3 (n)
  • 97.28 (a)
  • 96 (a)
(Canis familiaris)
Mammalia POLDIP2 35
  • 92.12 (n)
  • 97.01 (a)
  • 96 (a)
(Mus musculus)
Mammalia Poldip2 35
  • 89.67 (n)
  • 95.11 (a)
Poldip2 16
Poldip2 36
  • 95 (a)
(Pan troglodytes)
Mammalia POLDIP2 35
  • 99.31 (n)
  • 99.31 (a)
(Monodelphis domestica)
Mammalia POLDIP2 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia POLDIP2 36
  • 91 (a)
(Gallus gallus)
Aves TSR1 35
  • 79.61 (n)
  • 88.43 (a)
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia poldip2 35
  • 73.56 (n)
  • 87.71 (a)
Str.6271 35
(Danio rerio)
Actinopterygii Dr.1683 35
poldip2 35
  • 71.4 (n)
  • 79.39 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001153 35
  • 64.32 (n)
  • 72.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12162 35
  • 63.48 (n)
  • 69.28 (a)
CG12162 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea tag-307 35
  • 47.23 (n)
  • 39.58 (a)
tag-307 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8578 36
  • 45 (a)
Species with no ortholog for POLDIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLDIP2 Gene

Gene Tree for POLDIP2 (if available)
Gene Tree for POLDIP2 (if available)

Paralogs for POLDIP2 Gene

(1) SIMAP similar genes for POLDIP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with POLDIP2: view

No data available for Paralogs for POLDIP2 Gene

Variants for POLDIP2 Gene

Sequence variations from dbSNP and Humsavar for POLDIP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs13469 -- 28,349,109(-) GTCTC(A/G)CTGCA reference, synonymous-codon
rs735089 -- 28,348,990(-) TAACT(C/T)TGGGC intron-variant
rs1053195 -- 28,347,687(-) CCCTG(A/G)TAGGG utr-variant-3-prime
rs1065361 -- 28,347,790(-) CTTGG(A/C)CACCC utr-variant-3-prime
rs1858837 -- 28,349,905(-) CAGCG(A/G)GGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLDIP2 Gene

Variant ID Type Subtype PubMed ID
nsv519388 CNV Loss 19592680
nsv2017 CNV Insertion 18451855

Variation tolerance for POLDIP2 Gene

Gene Damage Index Score: 1.51; 29.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for POLDIP2 Gene

Disorders for POLDIP2 Gene

Relevant External Links for POLDIP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for POLDIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLDIP2 Gene

Publications for POLDIP2 Gene

  1. Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen. (PMID: 12522211) Liu L. … Lee M.Y.W.T. (J. Biol. Chem. 2003) 2 3 4 67
  2. Complex sense-antisense architecture of TNFAIP1/POLDIP2 on 17q11.2 represents a novel transcriptional structural-functional gene module involved in breast cancer progression. (PMID: 20158880) Grinchuk O.V. … Kuznetsov V.A. (BMC Genomics 2010) 3 23
  3. The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38. (PMID: 17623671) Klaile E. … Lucka L. (J. Biol. Chem. 2007) 3 23
  4. Further characterization of human DNA polymerase delta interacting protein 38. (PMID: 15811854) Xie B. … Lee M.Y. (J. Biol. Chem. 2005) 3 23
  5. Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. (PMID: 26561776) Verrastro I. … Pitt A.R. (Free Radic. Biol. Med. 2016) 3

Products for POLDIP2 Gene

Sources for POLDIP2 Gene