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Aliases for POLDIP2 Gene

Aliases for POLDIP2 Gene

  • Polymerase (DNA-Directed), Delta Interacting Protein 2 2 3
  • 38 KDa DNA Polymerase Delta Interaction Protein 3 4
  • PDIP38 3 4
  • POLD4 3 4
  • P38 3 4
  • Polymerase Delta Interacting Protein 38 3

External Ids for POLDIP2 Gene

Previous GeneCards Identifiers for POLDIP2 Gene

  • GC17M026819
  • GC17M023697
  • GC17M026673
  • GC17M022882

Summaries for POLDIP2 Gene

Entrez Gene Summary for POLDIP2 Gene

  • This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit, as well as with proliferating cell nuclear antigen. The encoded protein maybe play a role in the ability of the replication fork to bypass DNA lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for POLDIP2 Gene

POLDIP2 (Polymerase (DNA-Directed), Delta Interacting Protein 2) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Metabolism.

Gene Wiki entry for POLDIP2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLDIP2 Gene

Genomics for POLDIP2 Gene

Regulatory Elements for POLDIP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for POLDIP2 Gene

Chromosome:
17
Start:
28,346,628 bp from pter
End:
28,357,589 bp from pter
Size:
10,962 bases
Orientation:
Minus strand

Genomic View for POLDIP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for POLDIP2 Gene

Proteins for POLDIP2 Gene

  • Protein details for POLDIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2S7-PDIP2_HUMAN
    Recommended name:
    Polymerase delta-interacting protein 2
    Protein Accession:
    Q9Y2S7
    Secondary Accessions:
    • B2R846
    • Q96JE4

    Protein attributes for POLDIP2 Gene

    Size:
    368 amino acids
    Molecular mass:
    42033 Da
    Quaternary structure:
    • Interacts with PCNA and POLD2.

neXtProt entry for POLDIP2 Gene

Proteomics data for POLDIP2 Gene at MOPED

Post-translational modifications for POLDIP2 Gene

  • Ubiquitination at Lys 223
  • Modification sites at PhosphoSitePlus

Other Protein References for POLDIP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for POLDIP2 Gene

Domains & Families for POLDIP2 Gene

Protein Domains for POLDIP2 Gene

Suggested Antigen Peptide Sequences for POLDIP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2S7

UniProtKB/Swiss-Prot:

PDIP2_HUMAN :
  • Contains 1 apaG domain.
Domain:
  • Contains 1 apaG domain.
genes like me logo Genes that share domains with POLDIP2: view

No data available for Gene Families for POLDIP2 Gene

Function for POLDIP2 Gene

Gene Ontology (GO) - Molecular Function for POLDIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with POLDIP2: view
genes like me logo Genes that share phenotypes with POLDIP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POLDIP2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for POLDIP2 Gene

Localization for POLDIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLDIP2 Gene

Gene Ontology (GO) - Cellular Components for POLDIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IDA --
GO:0042645 mitochondrial nucleoid IDA 18063578
genes like me logo Genes that share ontologies with POLDIP2: view

No data available for Subcellular locations from COMPARTMENTS for POLDIP2 Gene

Pathways & Interactions for POLDIP2 Gene

SuperPathways for POLDIP2 Gene

Superpath Contained pathways
1 Lagging Strand Synthesis
2 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
3 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
4 DNA Double-Strand Break Repair
5 Mismatch repair
genes like me logo Genes that share pathways with POLDIP2: view

Interacting Proteins for POLDIP2 Gene

Gene Ontology (GO) - Biological Process for POLDIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070584 mitochondrion morphogenesis IEA --
genes like me logo Genes that share ontologies with POLDIP2: view

No data available for SIGNOR curated interactions for POLDIP2 Gene

Drugs & Compounds for POLDIP2 Gene

No Compound Related Data Available

Transcripts for POLDIP2 Gene

mRNA/cDNA for POLDIP2 Gene

Unigene Clusters for POLDIP2 Gene

Polymerase (DNA-directed), delta interacting protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POLDIP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLDIP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for POLDIP2 Gene

GeneLoc Exon Structure for
POLDIP2
ECgene alternative splicing isoforms for
POLDIP2

Expression for POLDIP2 Gene

mRNA expression in normal human tissues for POLDIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for POLDIP2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.4).

Protein differential expression in normal tissues from HIPED for POLDIP2 Gene

This gene is overexpressed in Adrenal (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for POLDIP2 Gene



SOURCE GeneReport for Unigene cluster for POLDIP2 Gene Hs.241543

genes like me logo Genes that share expression patterns with POLDIP2: view

Protein tissue co-expression partners for POLDIP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for POLDIP2 Gene

Orthologs for POLDIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for POLDIP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POLDIP2 35
  • 92.3 (n)
  • 97.28 (a)
POLDIP2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLDIP2 35
  • 92.12 (n)
  • 97.01 (a)
POLDIP2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Poldip2 35
  • 89.67 (n)
  • 95.11 (a)
Poldip2 16
Poldip2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLDIP2 35
  • 99.31 (n)
  • 99.31 (a)
oppossum
(Monodelphis domestica)
Mammalia POLDIP2 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLDIP2 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSR1 35
  • 79.61 (n)
  • 88.43 (a)
POLDIP2 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia poldip2 35
  • 73.56 (n)
  • 87.71 (a)
Str.6271 35
zebrafish
(Danio rerio)
Actinopterygii Dr.1683 35
poldip2 35
  • 71.4 (n)
  • 79.39 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001153 35
  • 64.32 (n)
  • 72.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12162 35
  • 63.48 (n)
  • 69.28 (a)
CG12162 36
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tag-307 35
  • 47.23 (n)
  • 39.58 (a)
tag-307 36
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8578 36
  • 45 (a)
OneToOne
Species with no ortholog for POLDIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLDIP2 Gene

ENSEMBL:
Gene Tree for POLDIP2 (if available)
TreeFam:
Gene Tree for POLDIP2 (if available)

Paralogs for POLDIP2 Gene

(1) SIMAP similar genes for POLDIP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with POLDIP2: view

No data available for Paralogs for POLDIP2 Gene

Variants for POLDIP2 Gene

Sequence variations from dbSNP and Humsavar for POLDIP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs199635094 -- 28,351,051(+) CAGTT(A/G)CAGGG intron-variant
rs189407094 -- 28,348,774(+) TAAGC(C/T)AGCCA intron-variant
rs115552897 -- 28,352,233(+) GAATT(A/T)TTTCT intron-variant
rs113989645 -- 28,349,164(+) GTTCC(A/C/T)GTAAA splice-acceptor-variant
rs113418845 -- 28,349,994(+) GTAGG(C/T)AGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLDIP2 Gene

Variant ID Type Subtype PubMed ID
nsv519388 CNV Loss 19592680
nsv2017 CNV Insertion 18451855

Variation tolerance for POLDIP2 Gene

Gene Damage Index Score: 1.51; 29.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLDIP2 Gene

HapMap Linkage Disequilibrium report
POLDIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLDIP2 Gene

Disorders for POLDIP2 Gene

Relevant External Links for POLDIP2

Genetic Association Database (GAD)
POLDIP2
Human Genome Epidemiology (HuGE) Navigator
POLDIP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLDIP2
genes like me logo Genes that share disorders with POLDIP2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLDIP2 Gene

Publications for POLDIP2 Gene

  1. Complex sense-antisense architecture of TNFAIP1/POLDIP2 on 17q11.2 represents a novel transcriptional structural-functional gene module involved in breast cancer progression. (PMID: 20158880) Grinchuk O.V. … Kuznetsov V.A. (BMC Genomics 2010) 23 67
  2. PDIP38 is a novel mitotic spindle-associated protein that affects spindle organization and chromosome segregation. (PMID: 18843206) Klaile E. … MA1ller M.M. (Cell Cycle 2008) 23 67
  3. Solution structure of ApaG from Xanthomonas axonopodis pv. citri reveals a fibronectin-3 fold. (PMID: 17256769) Cicero D.O. … Spisni A. (Proteins 2007) 23 67
  4. The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38. (PMID: 17623671) Klaile E. … Lucka L. (J. Biol. Chem. 2007) 23 67
  5. Further characterization of human DNA polymerase delta interacting protein 38. (PMID: 15811854) Xie B. … Lee M.Y. (J. Biol. Chem. 2005) 23 67

Products for POLDIP2 Gene

Sources for POLDIP2 Gene

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